PUDP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The encoded protein has no known biological function. This gene has a pseudogene on chromosome 1. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H2A acetylation (GO:0043968)5.45936882
2chromatin remodeling at centromere (GO:0031055)4.90316924
3CENP-A containing nucleosome assembly (GO:0034080)4.88903463
4establishment of integrated proviral latency (GO:0075713)4.65210045
5histone exchange (GO:0043486)4.38861487
6synapsis (GO:0007129)4.32942658
7proteasome assembly (GO:0043248)4.30316812
8mitotic metaphase plate congression (GO:0007080)4.28756566
9purine nucleobase biosynthetic process (GO:0009113)4.22627054
10DNA replication checkpoint (GO:0000076)4.06171569
11DNA strand elongation involved in DNA replication (GO:0006271)4.03622309
12protein localization to kinetochore (GO:0034501)3.99838800
13DNA strand elongation (GO:0022616)3.95414396
14IMP biosynthetic process (GO:0006188)3.94328541
15DNA replication-independent nucleosome assembly (GO:0006336)3.88891916
16DNA replication-independent nucleosome organization (GO:0034724)3.88891916
17metaphase plate congression (GO:0051310)3.82415699
18telomere maintenance via semi-conservative replication (GO:0032201)3.77712947
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.61047406
20IMP metabolic process (GO:0046040)3.57614421
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.57379783
22regulation of mitotic spindle checkpoint (GO:1903504)3.57379783
23spindle checkpoint (GO:0031577)3.57137819
24ribosome assembly (GO:0042255)3.56488437
25establishment of viral latency (GO:0019043)3.55060654
26mitotic spindle checkpoint (GO:0071174)3.54572899
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.54215597
28nucleobase biosynthetic process (GO:0046112)3.49575962
29negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.49435402
30negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.49435402
31negative regulation of mitotic sister chromatid segregation (GO:0033048)3.49435402
32negative regulation of mitotic sister chromatid separation (GO:2000816)3.49435402
33negative regulation of sister chromatid segregation (GO:0033046)3.49435402
34DNA ligation (GO:0006266)3.49235109
35negative regulation of chromosome segregation (GO:0051985)3.45524751
36DNA replication-dependent nucleosome assembly (GO:0006335)3.44122614
37DNA replication-dependent nucleosome organization (GO:0034723)3.44122614
38L-serine metabolic process (GO:0006563)3.43668002
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43560875
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39332862
41spliceosomal snRNP assembly (GO:0000387)3.37681516
42mitotic spindle assembly checkpoint (GO:0007094)3.34866284
43mitotic sister chromatid segregation (GO:0000070)3.34717473
44spindle assembly checkpoint (GO:0071173)3.32895363
45establishment of chromosome localization (GO:0051303)3.29420463
46regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.28773985
47regulation of mitotic metaphase/anaphase transition (GO:0030071)3.28773985
48regulation of helicase activity (GO:0051095)3.28116652
49protein localization to chromosome, centromeric region (GO:0071459)3.27525572
50negative regulation of ligase activity (GO:0051352)3.21000080
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21000080
52histone mRNA metabolic process (GO:0008334)3.20372930
53mitotic recombination (GO:0006312)3.20339169
54regulation of chromosome segregation (GO:0051983)3.20270494
55cullin deneddylation (GO:0010388)3.18531807
56telomere maintenance via recombination (GO:0000722)3.16550860
57ribosomal large subunit biogenesis (GO:0042273)3.15284023
58formation of translation preinitiation complex (GO:0001731)3.15072999
59DNA double-strand break processing (GO:0000729)3.14012842
60ATP-dependent chromatin remodeling (GO:0043044)3.13153013
61mitotic nuclear envelope disassembly (GO:0007077)3.12165573
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.11250973
63hyperosmotic salinity response (GO:0042538)3.10449595
64regulation of sister chromatid segregation (GO:0033045)3.10360985
65regulation of mitotic sister chromatid separation (GO:0010965)3.10360985
66regulation of mitotic sister chromatid segregation (GO:0033047)3.10360985
67non-recombinational repair (GO:0000726)3.09451473
68double-strand break repair via nonhomologous end joining (GO:0006303)3.09451473
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.09249962
70negative regulation of DNA-dependent DNA replication (GO:2000104)3.08615984
71nuclear pore complex assembly (GO:0051292)3.08133193
72DNA damage response, detection of DNA damage (GO:0042769)3.07618148
73DNA catabolic process, exonucleolytic (GO:0000738)3.04899219
74DNA replication initiation (GO:0006270)3.02430015
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01630833
76regulation of meiosis I (GO:0060631)3.00437051
77mitotic sister chromatid cohesion (GO:0007064)2.99142063
78mitotic chromosome condensation (GO:0007076)2.99072469
79kinetochore organization (GO:0051383)2.96715949
80mitotic G2/M transition checkpoint (GO:0044818)2.96264530
81sister chromatid segregation (GO:0000819)2.95839181
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91933357
83membrane disassembly (GO:0030397)2.90171265
84nuclear envelope disassembly (GO:0051081)2.90171265
85somatic hypermutation of immunoglobulin genes (GO:0016446)2.89590031
86somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89590031
87telomere maintenance via telomere lengthening (GO:0010833)2.88122375
88nucleotide-excision repair, DNA gap filling (GO:0006297)2.87935080
89negative regulation of mitosis (GO:0045839)2.87836348
90cell cycle G1/S phase transition (GO:0044843)2.85110545
91G1/S transition of mitotic cell cycle (GO:0000082)2.85110545
92protein deneddylation (GO:0000338)2.84002680
93regulation of double-strand break repair via homologous recombination (GO:0010569)2.82729523
94ribosomal small subunit assembly (GO:0000028)2.82064024
95cholesterol biosynthetic process (GO:0006695)2.81451485
96base-excision repair (GO:0006284)2.80786441
97kinetochore assembly (GO:0051382)2.79670668
98positive regulation of ligase activity (GO:0051351)2.79185801
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76759951
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76759951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.02018053
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.85513333
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.71475642
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.12196226
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.71719181
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.41175898
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.31398413
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.22043987
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.10363157
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91404039
11ELK1_19687146_ChIP-ChIP_HELA_Human2.74689814
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.71184641
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.69619156
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.63796927
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51128209
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49157274
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.45866030
18AR_21909140_ChIP-Seq_LNCAP_Human2.40467016
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38009782
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37969864
21GATA1_22025678_ChIP-Seq_K562_Human2.34597802
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32730928
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24668249
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21299136
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17484217
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16470200
27VDR_23849224_ChIP-Seq_CD4+_Human2.09627344
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03946222
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03364356
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99488285
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92729797
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88709156
33FOXP3_21729870_ChIP-Seq_TREG_Human1.85223578
34DCP1A_22483619_ChIP-Seq_HELA_Human1.82756043
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.81298575
36TTF2_22483619_ChIP-Seq_HELA_Human1.78396916
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73129825
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72960872
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70869912
40GABP_19822575_ChIP-Seq_HepG2_Human1.69402931
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64287460
42ZNF274_21170338_ChIP-Seq_K562_Hela1.62822478
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57113536
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56945844
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55531788
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52932879
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52590426
48NANOG_16153702_ChIP-ChIP_HESCs_Human1.50344556
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50196024
50FUS_26573619_Chip-Seq_HEK293_Human1.49413381
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47319046
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47261999
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46527362
54XRN2_22483619_ChIP-Seq_HELA_Human1.45702026
55MYC_18940864_ChIP-ChIP_HL60_Human1.43732071
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42324879
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.35783512
58EWS_26573619_Chip-Seq_HEK293_Human1.35191580
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.33875841
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31662186
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30238390
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30010666
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28745568
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.24774312
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24752932
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22981748
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22319155
68SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19461608
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18748844
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17617908
71VDR_22108803_ChIP-Seq_LS180_Human1.17478720
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.12764549
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08480808
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08095996
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06875656
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05761090
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.04729495
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02186082
79NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01797111
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01740428
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01410415
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97566605
83NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90395566
84WT1_19549856_ChIP-ChIP_CCG9911_Human0.88072516
85ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85548242
86STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82316575
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82004991
88IGF1R_20145208_ChIP-Seq_DFB_Human0.81961655
89GATA1_26923725_Chip-Seq_HPCs_Mouse0.81797796
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81738774
91SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80963917
92KDM5A_27292631_Chip-Seq_BREAST_Human0.80440547
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78798497
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77450978
95IRF1_19129219_ChIP-ChIP_H3396_Human0.74267083
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.73940184
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.73582840
98KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71529257
99ELK1_22589737_ChIP-Seq_MCF10A_Human0.70689312
100P300_19829295_ChIP-Seq_ESCs_Human0.70611940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.27693038
2MP0003693_abnormal_embryo_hatching4.08059015
3MP0008058_abnormal_DNA_repair3.85216748
4MP0004957_abnormal_blastocyst_morpholog3.68665044
5MP0003111_abnormal_nucleus_morphology3.33108348
6MP0003941_abnormal_skin_development3.13128315
7MP0003077_abnormal_cell_cycle2.87400771
8MP0008932_abnormal_embryonic_tissue2.80372375
9MP0008057_abnormal_DNA_replication2.50274617
10MP0003890_abnormal_embryonic-extraembry2.44923486
11MP0010030_abnormal_orbit_morphology2.30902484
12MP0003718_maternal_effect2.25830731
13MP0006035_abnormal_mitochondrial_morpho2.21727529
14MP0008789_abnormal_olfactory_epithelium2.10430137
15MP0008877_abnormal_DNA_methylation2.08518648
16MP0009672_abnormal_birth_weight2.06543074
17MP0001529_abnormal_vocalization2.06171342
18MP0001293_anophthalmia2.02992643
19MP0006292_abnormal_olfactory_placode1.99654714
20MP0002102_abnormal_ear_morphology1.86271121
21MP0003806_abnormal_nucleotide_metabolis1.85424542
22MP0009697_abnormal_copulation1.84849868
23MP0001730_embryonic_growth_arrest1.80666975
24MP0003786_premature_aging1.74257580
25MP0008007_abnormal_cellular_replicative1.67742176
26MP0001697_abnormal_embryo_size1.66835915
27MP0003937_abnormal_limbs/digits/tail_de1.61488538
28MP0002084_abnormal_developmental_patter1.54928303
29MP0005499_abnormal_olfactory_system1.52180090
30MP0005394_taste/olfaction_phenotype1.52180090
31MP0005380_embryogenesis_phenotype1.50322008
32MP0001672_abnormal_embryogenesis/_devel1.50322008
33MP0000749_muscle_degeneration1.48726416
34MP0002085_abnormal_embryonic_tissue1.47234024
35MP0003567_abnormal_fetal_cardiomyocyte1.45309255
36MP0006036_abnormal_mitochondrial_physio1.44117031
37MP0002233_abnormal_nose_morphology1.41611054
38MP0000372_irregular_coat_pigmentation1.37441116
39MP0000358_abnormal_cell_content/1.34008984
40MP0004215_abnormal_myocardial_fiber1.33856886
41MP0000350_abnormal_cell_proliferation1.31282260
42MP0009703_decreased_birth_body1.29942613
43MP0002210_abnormal_sex_determination1.29536493
44MP0003984_embryonic_growth_retardation1.27922016
45MP0002080_prenatal_lethality1.27912602
46MP0002088_abnormal_embryonic_growth/wei1.24427172
47MP0003119_abnormal_digestive_system1.23566886
48MP0001929_abnormal_gametogenesis1.22464463
49MP0001346_abnormal_lacrimal_gland1.20499601
50MP0004133_heterotaxia1.19326746
51MP0002938_white_spotting1.15622085
52MP0000537_abnormal_urethra_morphology1.15490946
53MP0002160_abnormal_reproductive_system1.14182777
54MP0001145_abnormal_male_reproductive1.13651394
55MP0004147_increased_porphyrin_level1.11783404
56MP0000049_abnormal_middle_ear1.10814592
57MP0000313_abnormal_cell_death1.10586258
58MP0003878_abnormal_ear_physiology1.09108173
59MP0005377_hearing/vestibular/ear_phenot1.09108173
60MP0001286_abnormal_eye_development1.08487851
61MP0001764_abnormal_homeostasis1.06799760
62MP0000653_abnormal_sex_gland1.04594281
63MP0005367_renal/urinary_system_phenotyp1.03725496
64MP0000516_abnormal_urinary_system1.03725496
65MP0010307_abnormal_tumor_latency1.02482354
66MP0002697_abnormal_eye_size1.02248675
67MP0003186_abnormal_redox_activity0.99195454
68MP0003136_yellow_coat_color0.98866073
69MP0003943_abnormal_hepatobiliary_system0.98244909
70MP0000647_abnormal_sebaceous_gland0.90709896
71MP0004197_abnormal_fetal_growth/weight/0.90542945
72MP0003221_abnormal_cardiomyocyte_apopto0.90002717
73MP0002111_abnormal_tail_morphology0.88011765
74MP0006072_abnormal_retinal_apoptosis0.86557335
75MP0003755_abnormal_palate_morphology0.85951711
76MP0010352_gastrointestinal_tract_polyps0.84025271
77MP0002086_abnormal_extraembryonic_tissu0.82849133
78MP0001119_abnormal_female_reproductive0.82483562
79MP0005248_abnormal_Harderian_gland0.80710536
80MP0001984_abnormal_olfaction0.80491753
81MP0005395_other_phenotype0.78021859
82MP0003698_abnormal_male_reproductive0.77371326
83MP0005330_cardiomyopathy0.76475770
84MP0008995_early_reproductive_senescence0.75234365
85MP0004019_abnormal_vitamin_homeostasis0.74763393
86MP0003861_abnormal_nervous_system0.74161659
87MP0002092_abnormal_eye_morphology0.72350733
88MP0002837_dystrophic_cardiac_calcinosis0.71262224
89MP0000490_abnormal_crypts_of0.70896808
90MP0003938_abnormal_ear_development0.70570138
91MP0001177_atelectasis0.70306274
92MP0004145_abnormal_muscle_electrophysio0.69116428
93MP0000751_myopathy0.68224381
94MP0002269_muscular_atrophy0.68034953
95MP0005391_vision/eye_phenotype0.68018309
96MP0005389_reproductive_system_phenotype0.66907439
97MP0003935_abnormal_craniofacial_develop0.64158190
98MP0002090_abnormal_vision0.63778446
99MP0001485_abnormal_pinna_reflex0.60957015
100MP0000566_synostosis0.59818202

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.15760773
2Increased serum pyruvate (HP:0003542)3.69784469
3Abnormality of glycolysis (HP:0004366)3.65629263
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.52271766
5Abnormal lung lobation (HP:0002101)3.45772799
6Generalized aminoaciduria (HP:0002909)3.26192196
7Chromsome breakage (HP:0040012)3.22315875
8Proximal tubulopathy (HP:0000114)3.18405615
9Colon cancer (HP:0003003)2.98408980
10Meckel diverticulum (HP:0002245)2.93097155
11Microvesicular hepatic steatosis (HP:0001414)2.86830105
12Hyperglycinemia (HP:0002154)2.78529421
13Reticulocytopenia (HP:0001896)2.72285789
14Abnormality of the ileum (HP:0001549)2.69834707
15Abnormality of chromosome stability (HP:0003220)2.67009343
16Abnormality of the preputium (HP:0100587)2.57039547
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.52164631
18Abnormality of methionine metabolism (HP:0010901)2.50210001
19Acute necrotizing encephalopathy (HP:0006965)2.49740221
20Abnormality of serum amino acid levels (HP:0003112)2.44877268
21Abnormality of glycine metabolism (HP:0010895)2.44176016
22Abnormality of serine family amino acid metabolism (HP:0010894)2.44176016
23Acute encephalopathy (HP:0006846)2.43928931
24Duodenal stenosis (HP:0100867)2.41720524
25Small intestinal stenosis (HP:0012848)2.41720524
26Pendular nystagmus (HP:0012043)2.39738456
27Agnosia (HP:0010524)2.37853546
28Hyperglycinuria (HP:0003108)2.33808675
29Degeneration of anterior horn cells (HP:0002398)2.32706263
30Abnormality of the anterior horn cell (HP:0006802)2.32706263
31Horseshoe kidney (HP:0000085)2.31456308
32Cortical dysplasia (HP:0002539)2.31389974
33Gonadotropin excess (HP:0000837)2.30266353
34True hermaphroditism (HP:0010459)2.29322464
35Stenosis of the external auditory canal (HP:0000402)2.27470777
36Increased CSF lactate (HP:0002490)2.27031667
37Type I transferrin isoform profile (HP:0003642)2.23190851
38Abnormal mitochondria in muscle tissue (HP:0008316)2.22928493
39Exercise-induced muscle cramps (HP:0003710)2.20548454
40Birth length less than 3rd percentile (HP:0003561)2.20465456
41Pancreatic fibrosis (HP:0100732)2.19468701
42Abnormality of the duodenum (HP:0002246)2.19453758
43Sloping forehead (HP:0000340)2.16802636
44Multiple enchondromatosis (HP:0005701)2.16762089
45Nephroblastoma (Wilms tumor) (HP:0002667)2.14239279
46Preaxial hand polydactyly (HP:0001177)2.10506814
47Amniotic constriction ring (HP:0009775)2.08512823
48Abnormality of placental membranes (HP:0011409)2.08512823
49Hypoplastic pelvis (HP:0008839)2.07584275
50Embryonal renal neoplasm (HP:0011794)2.05417669
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04696393
52Medulloblastoma (HP:0002885)2.04357139
53Abnormal protein glycosylation (HP:0012346)2.02813477
54Abnormal glycosylation (HP:0012345)2.02813477
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02813477
56Abnormal protein N-linked glycosylation (HP:0012347)2.02813477
57Reduced antithrombin III activity (HP:0001976)2.02232394
58Supernumerary spleens (HP:0009799)2.01687810
59Anencephaly (HP:0002323)1.99564379
60Bifid tongue (HP:0010297)1.98716788
61Intrahepatic cholestasis (HP:0001406)1.98083845
62Ependymoma (HP:0002888)1.97853155
63Mitochondrial inheritance (HP:0001427)1.97437922
64Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95405578
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.94637506
66Cerebral edema (HP:0002181)1.93340342
67Progressive macrocephaly (HP:0004481)1.92915656
68Increased serum lactate (HP:0002151)1.92030870
69Long clavicles (HP:0000890)1.89413517
70Increased nuchal translucency (HP:0010880)1.88150164
71Hepatic necrosis (HP:0002605)1.87116063
72Prominent metopic ridge (HP:0005487)1.86830808
73Facial cleft (HP:0002006)1.85837719
74Carpal bone hypoplasia (HP:0001498)1.84832910
75Abnormality of the metopic suture (HP:0005556)1.84801658
76Glycosuria (HP:0003076)1.84643565
77Abnormality of urine glucose concentration (HP:0011016)1.84643565
78Abnormality of the fetal cardiovascular system (HP:0010948)1.84274733
79Abnormal umbilical cord blood vessels (HP:0011403)1.84274733
80Single umbilical artery (HP:0001195)1.84274733
81Methylmalonic acidemia (HP:0002912)1.80550342
82Abnormality of the labia (HP:0000058)1.80109806
83Pancreatic cysts (HP:0001737)1.79934479
84Increased hepatocellular lipid droplets (HP:0006565)1.79634263
85Abnormality of the vitamin B12 metabolism (HP:0004341)1.79531770
86Absent radius (HP:0003974)1.78738741
87Popliteal pterygium (HP:0009756)1.78110571
88Rhabdomyosarcoma (HP:0002859)1.77457192
89Sclerocornea (HP:0000647)1.76498785
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74798897
91Abnormality of alanine metabolism (HP:0010916)1.74798897
92Hyperalaninemia (HP:0003348)1.74798897
93Postnatal microcephaly (HP:0005484)1.73766706
94Triphalangeal thumb (HP:0001199)1.73097387
95Hepatocellular necrosis (HP:0001404)1.70913637
96Postaxial foot polydactyly (HP:0001830)1.69953080
97Median cleft lip (HP:0000161)1.69015980
98Lipid accumulation in hepatocytes (HP:0006561)1.68979313
99Absent forearm bone (HP:0003953)1.68152372
100Aplasia involving forearm bones (HP:0009822)1.68152372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.16872889
2TTK3.31192630
3NEK13.23234364
4CDC72.92859848
5SRPK12.86494085
6PLK42.77140964
7PBK2.76494471
8TRIM282.64214407
9PDK22.58023957
10CDK192.57633218
11MST42.56639755
12TSSK62.56281674
13VRK22.53171996
14EIF2AK32.33762493
15PLK32.32206727
16ZAK2.16816855
17MKNK22.16346888
18EIF2AK12.13030779
19WEE12.07211561
20MKNK12.02910331
21WNK32.02119691
22STK161.97073557
23ACVR1B1.78900563
24PLK11.78709012
25VRK11.72420500
26BMPR1B1.62086646
27TNIK1.44776685
28PNCK1.29984751
29CCNB11.26362301
30OBSCN1.22234315
31NUAK11.20228038
32ERBB41.18590044
33ATR1.13476857
34BCR1.12922893
35BRSK21.12587552
36AURKA1.11909752
37CHEK21.10232321
38DYRK31.08829641
39NME11.07426639
40RPS6KA41.07288331
41AURKB1.04820064
42PASK1.01899696
43MAP2K70.97168798
44TAF10.96518511
45EPHA40.96021064
46MAP3K120.86303282
47CHEK10.86272539
48BCKDK0.84282118
49NEK90.83632573
50BRSK10.83022588
51PLK20.80577351
52TGFBR10.79929713
53MAP4K20.78632513
54STK100.78627857
55EIF2AK20.77424662
56OXSR10.76134423
57DYRK20.76129182
58MAP3K40.74682765
59ALK0.73870607
60MAP3K80.72237601
61NEK20.72079729
62ATM0.71886529
63STK38L0.68836019
64STK40.68356652
65STK390.66138063
66PAK40.64813190
67NME20.63648153
68BRAF0.60192303
69EPHB20.59149361
70ERBB30.58501211
71CDK70.58027152
72FGR0.57614729
73FGFR20.57064833
74CSNK1G10.56651564
75CSNK2A10.54595559
76CSNK2A20.52027046
77MAP3K50.45410625
78FGFR10.44517733
79CDK10.44293652
80STK30.42642027
81MELK0.40813394
82CASK0.40051367
83CLK10.39818595
84CSNK1E0.38005711
85MAP3K100.37909875
86CSNK1G30.35824424
87MET0.33904739
88GRK10.33799104
89CDK20.31686673
90PRKACB0.31237486
91PRKDC0.29325169
92ADRBK20.28054911
93CDK80.26363002
94PAK10.26342588
95SIK30.26249163
96CDK11A0.26212562
97CSNK1G20.26124340
98CDK180.25689985
99DMPK0.23096774
100CDK140.22796398

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.73992361
2Mismatch repair_Homo sapiens_hsa034303.55017908
3DNA replication_Homo sapiens_hsa030303.47708032
4Homologous recombination_Homo sapiens_hsa034402.65556681
5Non-homologous end-joining_Homo sapiens_hsa034502.64574260
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.52597736
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50593434
8Steroid biosynthesis_Homo sapiens_hsa001002.45924705
9Base excision repair_Homo sapiens_hsa034102.42809658
10Propanoate metabolism_Homo sapiens_hsa006402.20588045
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.17557607
12Nucleotide excision repair_Homo sapiens_hsa034202.17468637
13Protein export_Homo sapiens_hsa030602.15981316
14RNA transport_Homo sapiens_hsa030132.15296297
15RNA polymerase_Homo sapiens_hsa030202.07512143
16Spliceosome_Homo sapiens_hsa030402.05385465
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03664119
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01679069
19Fanconi anemia pathway_Homo sapiens_hsa034601.95403835
20Ribosome_Homo sapiens_hsa030101.92463766
21Pyruvate metabolism_Homo sapiens_hsa006201.88468334
22Cell cycle_Homo sapiens_hsa041101.88345894
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86817335
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85834574
25Basal transcription factors_Homo sapiens_hsa030221.78511266
26Parkinsons disease_Homo sapiens_hsa050121.78425666
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65299038
28One carbon pool by folate_Homo sapiens_hsa006701.65152475
29Oxidative phosphorylation_Homo sapiens_hsa001901.60269080
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.59979352
31Carbon metabolism_Homo sapiens_hsa012001.52009019
32RNA degradation_Homo sapiens_hsa030181.47575111
33Pyrimidine metabolism_Homo sapiens_hsa002401.46320026
34Fatty acid elongation_Homo sapiens_hsa000621.45947276
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42157200
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36715457
37Huntingtons disease_Homo sapiens_hsa050161.33310193
38Biosynthesis of amino acids_Homo sapiens_hsa012301.31318903
39Glutathione metabolism_Homo sapiens_hsa004801.14461328
40mRNA surveillance pathway_Homo sapiens_hsa030151.11742013
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08384003
42Purine metabolism_Homo sapiens_hsa002301.04900910
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01791571
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01161754
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99472599
46Butanoate metabolism_Homo sapiens_hsa006500.94931518
47Selenocompound metabolism_Homo sapiens_hsa004500.91232047
48Oocyte meiosis_Homo sapiens_hsa041140.87435841
49p53 signaling pathway_Homo sapiens_hsa041150.86176956
50Pentose phosphate pathway_Homo sapiens_hsa000300.85164562
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85087658
52Alzheimers disease_Homo sapiens_hsa050100.84013023
53Fatty acid metabolism_Homo sapiens_hsa012120.82861244
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82565992
55Vitamin B6 metabolism_Homo sapiens_hsa007500.81813953
56Folate biosynthesis_Homo sapiens_hsa007900.79748439
57Renin-angiotensin system_Homo sapiens_hsa046140.77610467
58Sulfur relay system_Homo sapiens_hsa041220.75853923
59Vitamin digestion and absorption_Homo sapiens_hsa049770.73037213
60N-Glycan biosynthesis_Homo sapiens_hsa005100.67838068
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67544288
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65567730
63Metabolic pathways_Homo sapiens_hsa011000.64924819
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62576198
65Arginine and proline metabolism_Homo sapiens_hsa003300.61081864
66Fatty acid degradation_Homo sapiens_hsa000710.59895629
67Basal cell carcinoma_Homo sapiens_hsa052170.55589389
68Retinol metabolism_Homo sapiens_hsa008300.54389333
69Galactose metabolism_Homo sapiens_hsa000520.53188475
70Phototransduction_Homo sapiens_hsa047440.52828499
71Starch and sucrose metabolism_Homo sapiens_hsa005000.52710181
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.50267112
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49414362
74Peroxisome_Homo sapiens_hsa041460.48733957
75Hedgehog signaling pathway_Homo sapiens_hsa043400.48465035
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48398404
77Cardiac muscle contraction_Homo sapiens_hsa042600.47641885
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47575755
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44606552
80beta-Alanine metabolism_Homo sapiens_hsa004100.43661594
81Sulfur metabolism_Homo sapiens_hsa009200.42518210
82Fat digestion and absorption_Homo sapiens_hsa049750.42077828
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40220216
84Wnt signaling pathway_Homo sapiens_hsa043100.37229030
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36969562
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36000654
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35692553
88Chemical carcinogenesis_Homo sapiens_hsa052040.34674991
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33271894
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.33004612
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30436884
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26944853
93Hippo signaling pathway_Homo sapiens_hsa043900.25961042
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.25480004
95TGF-beta signaling pathway_Homo sapiens_hsa043500.24938129
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.23528682
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.19596526
98Tight junction_Homo sapiens_hsa045300.19252060
99Adherens junction_Homo sapiens_hsa045200.17762485
100Fructose and mannose metabolism_Homo sapiens_hsa000510.15482022

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