PUF60

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.75998189
2proline biosynthetic process (GO:0006561)5.63859906
3DNA strand elongation involved in DNA replication (GO:0006271)4.99964424
4COPI coating of Golgi vesicle (GO:0048205)4.99363905
5Golgi transport vesicle coating (GO:0048200)4.99363905
6telomere maintenance via semi-conservative replication (GO:0032201)4.97690688
7formation of translation preinitiation complex (GO:0001731)4.97296878
8DNA strand elongation (GO:0022616)4.73721939
9replication fork processing (GO:0031297)4.64313652
10transcription from mitochondrial promoter (GO:0006390)4.60574670
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.57356238
12somatic diversification of immune receptors via somatic mutation (GO:0002566)4.56581347
13somatic hypermutation of immunoglobulin genes (GO:0016446)4.56581347
14protein maturation by protein folding (GO:0022417)4.43983658
15establishment of integrated proviral latency (GO:0075713)4.41439381
16peptidyl-arginine omega-N-methylation (GO:0035247)4.38283142
17viral mRNA export from host cell nucleus (GO:0046784)4.38147911
18maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.23472785
19nucleotide-excision repair, DNA gap filling (GO:0006297)4.19508130
20histone arginine methylation (GO:0034969)4.10608264
21telomere maintenance via recombination (GO:0000722)4.06651103
22mitochondrial DNA metabolic process (GO:0032042)4.03326145
23nuclear envelope reassembly (GO:0031468)4.01043501
24mitotic nuclear envelope reassembly (GO:0007084)4.01043501
25base-excision repair (GO:0006284)4.01017495
26regulation of translational fidelity (GO:0006450)3.98218793
27establishment of viral latency (GO:0019043)3.96962074
28mitotic G1 DNA damage checkpoint (GO:0031571)3.96048570
29DNA unwinding involved in DNA replication (GO:0006268)3.94209034
30establishment of apical/basal cell polarity (GO:0035089)3.84157304
31negative regulation of RNA splicing (GO:0033119)3.80267702
32negative regulation of mRNA processing (GO:0050686)3.80016464
33cullin deneddylation (GO:0010388)3.78264524
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74982565
35telomere maintenance via telomere lengthening (GO:0010833)3.73814219
36proline metabolic process (GO:0006560)3.72495881
37dosage compensation (GO:0007549)3.71686341
38spliceosomal tri-snRNP complex assembly (GO:0000244)3.71184820
39mitotic recombination (GO:0006312)3.67928824
40peptidyl-arginine methylation (GO:0018216)3.62148277
41peptidyl-arginine N-methylation (GO:0035246)3.62148277
42L-serine metabolic process (GO:0006563)3.61371769
43oxidative demethylation (GO:0070989)3.61339400
44regulation of mitochondrial translation (GO:0070129)3.60014070
45negative regulation of ligase activity (GO:0051352)3.57661110
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57661110
47mRNA cleavage (GO:0006379)3.55395607
48nucleobase-containing small molecule interconversion (GO:0015949)3.51824196
49protein deneddylation (GO:0000338)3.51722779
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.50372162
51DNA replication initiation (GO:0006270)3.50243289
52ribosome biogenesis (GO:0042254)3.50197753
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.47802595
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.46119561
55termination of RNA polymerase II transcription (GO:0006369)3.45108262
56DNA strand renaturation (GO:0000733)3.44862653
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.43124643
58embryonic process involved in female pregnancy (GO:0060136)3.42347330
59proteasome assembly (GO:0043248)3.42188322
60regulation of DNA damage checkpoint (GO:2000001)3.41676231
61mitotic G1/S transition checkpoint (GO:0044819)3.39253890
62GDP-mannose metabolic process (GO:0019673)3.36697831
63pentose-phosphate shunt (GO:0006098)3.36184841
64establishment of monopolar cell polarity (GO:0061162)3.32356857
65establishment or maintenance of monopolar cell polarity (GO:0061339)3.32356857
66retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.28393279
67mitotic sister chromatid segregation (GO:0000070)3.27825296
68regulation of cellular amino acid metabolic process (GO:0006521)3.27409252
69mitotic nuclear envelope disassembly (GO:0007077)3.25883760
70negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.24525087
71negative regulation of chromosome segregation (GO:0051985)3.23651749
72pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.22481711
73positive regulation of protein homooligomerization (GO:0032464)3.21516815
74regulation of translational termination (GO:0006449)3.20881592
75G1 DNA damage checkpoint (GO:0044783)3.20397128
76negative regulation of mRNA metabolic process (GO:1903312)3.20363494
77de novo posttranslational protein folding (GO:0051084)3.20006216
78base-excision repair, AP site formation (GO:0006285)3.19662788
79NADPH regeneration (GO:0006740)3.18563924
80guanosine-containing compound biosynthetic process (GO:1901070)3.18216140
81regulation of sister chromatid cohesion (GO:0007063)3.17320268
82protein retention in ER lumen (GO:0006621)3.14749358
83metallo-sulfur cluster assembly (GO:0031163)3.14706981
84iron-sulfur cluster assembly (GO:0016226)3.14706981
85pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.14056290
86DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13579758
87regulation of mammary gland epithelial cell proliferation (GO:0033599)3.13097772
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12396522
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12396522
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.12235396
91signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12235396
92de novo protein folding (GO:0006458)3.12087798
93spliceosomal snRNP assembly (GO:0000387)3.11355081
94mitochondrial fusion (GO:0008053)3.10288902
95IMP biosynthetic process (GO:0006188)3.09993930
96nucleobase biosynthetic process (GO:0046112)3.09547286
97DNA topological change (GO:0006265)3.09533689
98maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.09287401
99meiotic chromosome segregation (GO:0045132)3.08249879
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07553619
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07553619
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07553619
103signal transduction involved in cell cycle checkpoint (GO:0072395)3.06583488
104maturation of 5.8S rRNA (GO:0000460)3.06435565
105poly(A)+ mRNA export from nucleus (GO:0016973)3.06324046
106regulation of double-strand break repair via homologous recombination (GO:0010569)3.06211770
107maturation of SSU-rRNA (GO:0030490)3.05213465
108regulation of posttranscriptional gene silencing (GO:0060147)3.04723145
109regulation of gene silencing by miRNA (GO:0060964)3.04723145
110regulation of gene silencing by RNA (GO:0060966)3.04723145
111ribosome assembly (GO:0042255)3.03585806
112membrane disassembly (GO:0030397)3.02279575
113nuclear envelope disassembly (GO:0051081)3.02279575
114mRNA splicing, via spliceosome (GO:0000398)3.02278389
115RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.02278389
116positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.02057809
117negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.01482394
118pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.00583310
119glucose catabolic process (GO:0006007)2.99980579
120mitotic metaphase plate congression (GO:0007080)2.99246302
121RNA splicing, via transesterification reactions (GO:0000375)2.98434532
122tRNA aminoacylation for protein translation (GO:0006418)2.97751944
123regulation of protein homooligomerization (GO:0032462)2.97354948
124mRNA export from nucleus (GO:0006406)2.97179985
125pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.96909168
126negative regulation of cell size (GO:0045792)2.96623799
127postreplication repair (GO:0006301)2.95456475
128positive regulation of chromosome segregation (GO:0051984)2.95319509
129double-strand break repair via nonhomologous end joining (GO:0006303)2.94298792
130non-recombinational repair (GO:0000726)2.94298792
131RNA export from nucleus (GO:0006405)2.94229868
132DNA duplex unwinding (GO:0032508)2.92646604
133DNA geometric change (GO:0032392)2.90221356
134negative regulation of cell cycle arrest (GO:0071157)2.89878671
135mitotic chromosome condensation (GO:0007076)2.89238535
136mitochondrial RNA metabolic process (GO:0000959)2.88940854
137protein localization to kinetochore (GO:0034501)2.88523389
138regulation of ubiquitin-protein transferase activity (GO:0051438)2.87764358
139protein complex localization (GO:0031503)2.87742065
140rRNA transcription (GO:0009303)2.86275240
141sister chromatid segregation (GO:0000819)2.86115270
142transcription-coupled nucleotide-excision repair (GO:0006283)2.85493725
143protein targeting to mitochondrion (GO:0006626)2.85370117
144tRNA aminoacylation (GO:0043039)2.85186820
145amino acid activation (GO:0043038)2.85186820
146positive regulation of ligase activity (GO:0051351)2.84743538
147translational initiation (GO:0006413)2.84382950
148DNA replication-dependent nucleosome organization (GO:0034723)2.83335647
149DNA replication-dependent nucleosome assembly (GO:0006335)2.83335647
150negative regulation of JAK-STAT cascade (GO:0046426)2.82524006
151tRNA methylation (GO:0030488)2.80354468
152negative regulation of mitotic sister chromatid separation (GO:2000816)2.80290475
153negative regulation of mitotic sister chromatid segregation (GO:0033048)2.80290475
154negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.80290475
155negative regulation of sister chromatid segregation (GO:0033046)2.80290475
156ribonucleoprotein complex biogenesis (GO:0022613)2.79688923
157translesion synthesis (GO:0019985)2.79014999
158rRNA processing (GO:0006364)2.78506386
159UTP biosynthetic process (GO:0006228)2.77634755
160positive regulation of mitotic sister chromatid separation (GO:1901970)2.76770470
161positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76770470
162positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76770470
163folic acid metabolic process (GO:0046655)2.76071311
164mismatch repair (GO:0006298)2.75313866
165DNA damage response, detection of DNA damage (GO:0042769)2.73828303
166regulation of ligase activity (GO:0051340)2.73707055
167glycolytic process (GO:0006096)2.73324395
168DNA ligation (GO:0006266)2.70733624
169pentose metabolic process (GO:0019321)2.70399003
170pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.68561048
171CTP metabolic process (GO:0046036)2.68289128
172CTP biosynthetic process (GO:0006241)2.68289128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.64381806
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83989860
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.79646868
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.02831455
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70088625
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69763003
7MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46044223
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43491004
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.40201412
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40175865
11MYC_22102868_ChIP-Seq_BL_Human2.31219249
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29921707
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27547664
14* XRN2_22483619_ChIP-Seq_HELA_Human2.20322625
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16959806
16VDR_21846776_ChIP-Seq_THP-1_Human2.16354160
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02352985
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.01614944
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.97941132
20CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.97410869
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.93913737
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92625271
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92577960
24* GABP_19822575_ChIP-Seq_HepG2_Human1.91317187
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89971868
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89050750
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88056772
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83423511
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78301865
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74251825
31* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73762073
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73612810
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71923895
34ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66595071
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65561797
36* DCP1A_22483619_ChIP-Seq_HELA_Human1.64693612
37TTF2_22483619_ChIP-Seq_HELA_Human1.59933835
38VDR_23849224_ChIP-Seq_CD4+_Human1.59920503
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59017390
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.58536948
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56627678
42* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55580952
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54050598
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.52971624
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50149925
46KDM5A_27292631_Chip-Seq_BREAST_Human1.48815142
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47072313
48CIITA_25753668_ChIP-Seq_RAJI_Human1.45801623
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44141226
50FOXP3_21729870_ChIP-Seq_TREG_Human1.44137140
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.43861877
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42369045
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40208644
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37277173
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.36342375
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35210516
57* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34051310
58* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31275320
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30461012
60RACK7_27058665_Chip-Seq_MCF-7_Human1.29281053
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28387960
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28387960
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28387960
64LXR_22292898_ChIP-Seq_THP-1_Human1.27316073
65CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26627034
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25026313
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20724053
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20175787
69CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18330275
70TFEB_21752829_ChIP-Seq_HELA_Human1.18165183
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17617377
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16755340
73P68_20966046_ChIP-Seq_HELA_Human1.16496037
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16119179
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15775513
76* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15418339
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.15310471
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14990569
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14694036
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14276088
81AR_21909140_ChIP-Seq_LNCAP_Human1.13767772
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12892194
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.12716080
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11892257
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11750969
86ZNF263_19887448_ChIP-Seq_K562_Human1.11179734
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.10572061
88TP63_17297297_ChIP-ChIP_HaCaT_Human1.10420725
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09899405
90SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09165567
91* DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08042808
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.07669037
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07230016
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07032914
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06984697
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06059493
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.05859067
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03992890
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03413826
100* FOXP1_21924763_ChIP-Seq_HESCs_Human1.02868728
101* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02623106
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01773181
103SRF_21415370_ChIP-Seq_HL-1_Mouse1.01321539
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00830624
105* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00463581
106OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00287993
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00287743
108KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99989255
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99573111
110POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99380789
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99040099
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98821153
113KDM2B_26808549_Chip-Seq_DND41_Human0.98793839
114FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97629339
115* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97624219
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97430733
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97423744
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97289236
119SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97259849
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96777175
121SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95682018
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95331319
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94471989
124ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94176992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.39554147
2MP0010094_abnormal_chromosome_stability3.91529319
3MP0004957_abnormal_blastocyst_morpholog3.53838236
4MP0003111_abnormal_nucleus_morphology3.42938196
5MP0010030_abnormal_orbit_morphology3.39750118
6MP0003693_abnormal_embryo_hatching3.38377499
7MP0003077_abnormal_cell_cycle3.14805396
8MP0009278_abnormal_bone_marrow3.03960687
9MP0008260_abnormal_autophagy2.86667509
10MP0008058_abnormal_DNA_repair2.77667268
11MP0008877_abnormal_DNA_methylation2.77610757
12MP0002653_abnormal_ependyma_morphology2.65630085
13MP0005451_abnormal_body_composition2.60791380
14MP0004233_abnormal_muscle_weight2.50102554
15MP0003806_abnormal_nucleotide_metabolis2.41037865
16MP0003786_premature_aging2.40238808
17MP0008932_abnormal_embryonic_tissue2.39765569
18MP0002877_abnormal_melanocyte_morpholog2.38685771
19MP0003283_abnormal_digestive_organ2.34725798
20MP0001730_embryonic_growth_arrest2.18013352
21MP0008007_abnormal_cellular_replicative2.16805882
22MP0005058_abnormal_lysosome_morphology2.13696052
23MP0005501_abnormal_skin_physiology2.09497954
24MP0003705_abnormal_hypodermis_morpholog1.99513418
25MP0001697_abnormal_embryo_size1.95877263
26MP0000350_abnormal_cell_proliferation1.94455455
27MP0004858_abnormal_nervous_system1.91454438
28MP0003119_abnormal_digestive_system1.88687182
29MP0008995_early_reproductive_senescence1.88125498
30MP0005397_hematopoietic_system_phenotyp1.84948906
31MP0001545_abnormal_hematopoietic_system1.84948906
32MP0004133_heterotaxia1.82294764
33MP0002084_abnormal_developmental_patter1.79807271
34MP0002085_abnormal_embryonic_tissue1.76705656
35MP0010352_gastrointestinal_tract_polyps1.72106073
36MP0000751_myopathy1.72025755
37MP0009840_abnormal_foam_cell1.71174052
38MP0006035_abnormal_mitochondrial_morpho1.69560827
39MP0003123_paternal_imprinting1.68695326
40MP0004197_abnormal_fetal_growth/weight/1.67297829
41MP0005380_embryogenesis_phenotype1.64197142
42MP0001672_abnormal_embryogenesis/_devel1.64197142
43MP0002080_prenatal_lethality1.63056055
44MP0002396_abnormal_hematopoietic_system1.61112632
45MP0003890_abnormal_embryonic-extraembry1.58286182
46MP0002796_impaired_skin_barrier1.52091504
47MP0002086_abnormal_extraembryonic_tissu1.51201899
48MP0001293_anophthalmia1.49181278
49MP0000467_abnormal_esophagus_morphology1.47193261
50MP0006072_abnormal_retinal_apoptosis1.45536330
51MP0002019_abnormal_tumor_incidence1.45463241
52MP0005171_absent_coat_pigmentation1.44565747
53MP0003984_embryonic_growth_retardation1.43416863
54MP0000313_abnormal_cell_death1.42087690
55MP0000490_abnormal_crypts_of1.40304248
56MP0001529_abnormal_vocalization1.39872462
57MP0009333_abnormal_splenocyte_physiolog1.38827115
58MP0005076_abnormal_cell_differentiation1.37849460
59MP0002088_abnormal_embryonic_growth/wei1.37491387
60MP0002282_abnormal_trachea_morphology1.36307291
61MP0005257_abnormal_intraocular_pressure1.35797938
62MP0003186_abnormal_redox_activity1.35040759
63MP0006036_abnormal_mitochondrial_physio1.34435427
64MP0009672_abnormal_birth_weight1.32683383
65MP0005623_abnormal_meninges_morphology1.31215447
66MP0003567_abnormal_fetal_cardiomyocyte1.30412785
67MP0001727_abnormal_embryo_implantation1.27127519
68MP0000579_abnormal_nail_morphology1.26429559
69MP0003221_abnormal_cardiomyocyte_apopto1.24686256
70MP0008789_abnormal_olfactory_epithelium1.24620818
71MP0001346_abnormal_lacrimal_gland1.22786499
72MP0000747_muscle_weakness1.17614513
73MP0010234_abnormal_vibrissa_follicle1.12890136
74MP0000750_abnormal_muscle_regeneration1.10394079
75MP0010307_abnormal_tumor_latency1.10071525
76MP0002111_abnormal_tail_morphology1.09040560
77MP0002098_abnormal_vibrissa_morphology1.08774934
78MP0003763_abnormal_thymus_physiology1.08240400
79MP0001145_abnormal_male_reproductive1.07457364
80MP0002249_abnormal_larynx_morphology1.07209462
81MP0005499_abnormal_olfactory_system1.07139679
82MP0005394_taste/olfaction_phenotype1.07139679
83MP0003121_genomic_imprinting1.07095017
84MP0002009_preneoplasia1.06757947
85MP0003329_amyloid_beta_deposits1.06324134
86MP0002932_abnormal_joint_morphology1.06267643
87MP0009053_abnormal_anal_canal1.05377276
88MP0002210_abnormal_sex_determination1.03960326
89MP0001243_abnormal_dermal_layer1.02667877
90MP0000703_abnormal_thymus_morphology1.02211603
91MP0004808_abnormal_hematopoietic_stem1.01414783
92MP0003453_abnormal_keratinocyte_physiol1.01216924
93MP0002269_muscular_atrophy1.00639465
94MP0002751_abnormal_autonomic_nervous0.97073670
95MP0000566_synostosis0.96365391
96MP0001216_abnormal_epidermal_layer0.94546203
97MP0000537_abnormal_urethra_morphology0.93009625
98MP0005330_cardiomyopathy0.92949451
99MP0003942_abnormal_urinary_system0.90792782
100MP0000358_abnormal_cell_content/0.90012284
101MP0001661_extended_life_span0.87119455
102MP0000749_muscle_degeneration0.86956330
103MP0004185_abnormal_adipocyte_glucose0.86850128
104MP0000049_abnormal_middle_ear0.86848968
105MP0000003_abnormal_adipose_tissue0.86432613
106MP0001853_heart_inflammation0.84414210
107MP0005075_abnormal_melanosome_morpholog0.84153913
108MP0000678_abnormal_parathyroid_gland0.84098274
109MP0001881_abnormal_mammary_gland0.83766832
110MP0010771_integument_phenotype0.83153127
111MP0005023_abnormal_wound_healing0.82912908
112MP0002822_catalepsy0.82528054
113MP0003943_abnormal_hepatobiliary_system0.81971341
114MP0001849_ear_inflammation0.81004605
115MP0001929_abnormal_gametogenesis0.80428094
116MP0000689_abnormal_spleen_morphology0.80423045
117MP0000653_abnormal_sex_gland0.79836396
118MP0003122_maternal_imprinting0.78617728
119MP0003115_abnormal_respiratory_system0.78348791
120MP0002114_abnormal_axial_skeleton0.78009849
121MP0002938_white_spotting0.76653178
122MP0002060_abnormal_skin_morphology0.76146687
123MP0002398_abnormal_bone_marrow0.75744300
124MP0000762_abnormal_tongue_morphology0.75347521
125MP0000858_altered_metastatic_potential0.74356962
126MP0000685_abnormal_immune_system0.74046002
127MP0001340_abnormal_eyelid_morphology0.73942021
128MP0000428_abnormal_craniofacial_morphol0.73910569
129MP0002722_abnormal_immune_system0.72856991
130MP0005083_abnormal_biliary_tract0.72416288
131MP0000371_diluted_coat_color0.72183998
132MP0003315_abnormal_perineum_morphology0.71761064
133MP0000477_abnormal_intestine_morphology0.70449156
134MP0003935_abnormal_craniofacial_develop0.70241603
135MP0002092_abnormal_eye_morphology0.68465222
136MP0006054_spinal_hemorrhage0.68212880
137MP0003861_abnormal_nervous_system0.68057244
138MP0000534_abnormal_ureter_morphology0.67413396
139MP0002116_abnormal_craniofacial_bone0.67157631
140MP0003191_abnormal_cellular_cholesterol0.66856042
141MP0005174_abnormal_tail_pigmentation0.66811026
142MP0005384_cellular_phenotype0.66368615
143MP0000462_abnormal_digestive_system0.63156353
144MP0003566_abnormal_cell_adhesion0.63112487
145MP0005621_abnormal_cell_physiology0.62710335
146MP0002089_abnormal_postnatal_growth/wei0.62371067
147MP0002075_abnormal_coat/hair_pigmentati0.62268610
148MP0002697_abnormal_eye_size0.62180522
149MP0003718_maternal_effect0.60635694
150MP0005391_vision/eye_phenotype0.60119159

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)4.08904803
2Abnormal gallbladder physiology (HP:0012438)4.08904803
3Annular pancreas (HP:0001734)4.02614058
4Selective tooth agenesis (HP:0001592)3.90410266
5Rib fusion (HP:0000902)3.67290516
6Cerebral hypomyelination (HP:0006808)3.60666029
7Ependymoma (HP:0002888)3.58297118
8Poikiloderma (HP:0001029)3.55470450
9Microvesicular hepatic steatosis (HP:0001414)3.51699228
10Basal cell carcinoma (HP:0002671)3.44907006
11Abnormality of glycolysis (HP:0004366)3.34844331
12Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.34444709
13Ragged-red muscle fibers (HP:0003200)3.33890276
14Facial hemangioma (HP:0000329)3.27919471
15Broad distal phalanx of finger (HP:0009836)3.26589787
16Patellar aplasia (HP:0006443)3.18035313
17Hyperacusis (HP:0010780)3.11435918
18Concave nail (HP:0001598)3.04018248
19Medulloblastoma (HP:0002885)3.02780553
20Abnormality of the astrocytes (HP:0100707)3.02503679
21Astrocytoma (HP:0009592)3.02503679
22Ulnar bowing (HP:0003031)2.98413143
23Aplasia/Hypoplasia of the patella (HP:0006498)2.98234841
24Tongue fasciculations (HP:0001308)2.98230716
25Progressive muscle weakness (HP:0003323)2.96352773
26Colon cancer (HP:0003003)2.94663198
27Intestinal atresia (HP:0011100)2.90895121
28Neoplasm of the oral cavity (HP:0100649)2.89310738
29Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.85438373
30Vertebral hypoplasia (HP:0008417)2.85438373
31Abnormality of the umbilical cord (HP:0010881)2.83798475
32Increased serum pyruvate (HP:0003542)2.82772468
33Premature graying of hair (HP:0002216)2.81038479
34Spastic diplegia (HP:0001264)2.78215100
35Rectovaginal fistula (HP:0000143)2.77797844
36Rectal fistula (HP:0100590)2.77797844
37Testicular atrophy (HP:0000029)2.72280278
38Muscle fibrillation (HP:0010546)2.71900057
39Pustule (HP:0200039)2.71201457
40Glioma (HP:0009733)2.71067973
41Absent thumb (HP:0009777)2.69622577
42Abnormality of the anterior horn cell (HP:0006802)2.67240976
43Degeneration of anterior horn cells (HP:0002398)2.67240976
44Vaginal fistula (HP:0004320)2.67150559
45Abnormality of the aortic arch (HP:0012303)2.64779010
46Orthostatic hypotension (HP:0001278)2.63736201
47Abnormal number of incisors (HP:0011064)2.55999387
48Abnormal mitochondria in muscle tissue (HP:0008316)2.52504726
49Multiple enchondromatosis (HP:0005701)2.51116187
50Squamous cell carcinoma (HP:0002860)2.50749205
51Abnormality of the labia minora (HP:0012880)2.47671912
52Absent radius (HP:0003974)2.47389590
53Aplasia/hypoplasia of the humerus (HP:0006507)2.47218411
54Abnormality of the distal phalanges of the toes (HP:0010182)2.46950355
55Proximal placement of thumb (HP:0009623)2.46591668
56Missing ribs (HP:0000921)2.45530126
57Broad alveolar ridges (HP:0000187)2.45367310
58Achilles tendon contracture (HP:0001771)2.45352266
59Intestinal fistula (HP:0100819)2.44304649
60Muscle fiber atrophy (HP:0100295)2.42252067
61Insomnia (HP:0100785)2.41537253
62Short nail (HP:0001799)2.41322606
63Upper limb amyotrophy (HP:0009129)2.40063374
64Distal upper limb amyotrophy (HP:0007149)2.40063374
65Distal lower limb muscle weakness (HP:0009053)2.39693267
6611 pairs of ribs (HP:0000878)2.39135999
67Vertebral compression fractures (HP:0002953)2.37168629
68Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35284950
69Abnormal number of erythroid precursors (HP:0012131)2.33540740
70Shoulder girdle muscle weakness (HP:0003547)2.33495560
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32589460
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32589460
73Increased IgM level (HP:0003496)2.31792827
74Cholelithiasis (HP:0001081)2.31150037
75Abnormality of cells of the erythroid lineage (HP:0012130)2.30479699
76Short humerus (HP:0005792)2.30121012
77Hypokinesia (HP:0002375)2.30086614
78Deviation of the thumb (HP:0009603)2.29926063
79Abnormality of the fetal cardiovascular system (HP:0010948)2.28764254
80Abnormal umbilical cord blood vessels (HP:0011403)2.28764254
81Single umbilical artery (HP:0001195)2.28764254
82Aplasia involving forearm bones (HP:0009822)2.28606930
83Absent forearm bone (HP:0003953)2.28606930
84Distal lower limb amyotrophy (HP:0008944)2.25579132
85Congenital hip dislocation (HP:0001374)2.22885024
86Acute lymphatic leukemia (HP:0006721)2.21338277
87Abnormalities of placenta or umbilical cord (HP:0001194)2.18281537
88High anterior hairline (HP:0009890)2.17165200
89Type 2 muscle fiber atrophy (HP:0003554)2.16866071
90Absent epiphyses (HP:0010577)2.16556927
91Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.16556927
92Flattened epiphyses (HP:0003071)2.16061635
93Hypercortisolism (HP:0001578)2.14736209
94Rhabdomyosarcoma (HP:0002859)2.14438282
95Abnormality of the calcaneus (HP:0008364)2.12815316
96Metaphyseal cupping (HP:0003021)2.11392153
97Upper limb muscle weakness (HP:0003484)2.10609794
98Exercise intolerance (HP:0003546)2.09928267
99Increased serum lactate (HP:0002151)2.09837992
100Opisthotonus (HP:0002179)2.08656839
101Entropion (HP:0000621)2.08089058
102Centrally nucleated skeletal muscle fibers (HP:0003687)2.07722947
103Turricephaly (HP:0000262)2.07397158
104Glossoptosis (HP:0000162)2.07029968
105Male infertility (HP:0003251)2.06954403
106Hepatocellular necrosis (HP:0001404)2.06526170
107Hand muscle atrophy (HP:0009130)2.06461030
108Carpal bone hypoplasia (HP:0001498)2.06142589
109Generalized amyotrophy (HP:0003700)2.05475521
110Aplastic anemia (HP:0001915)2.05089420
111Acute encephalopathy (HP:0006846)2.04790046
112Abnormality of the lower motor neuron (HP:0002366)2.04019726
113Long palpebral fissure (HP:0000637)2.03966068
114Secondary amenorrhea (HP:0000869)2.03946391
115Overriding aorta (HP:0002623)2.03772397
116Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02594612
117Acute necrotizing encephalopathy (HP:0006965)2.01455576
118Increased intramyocellular lipid droplets (HP:0012240)2.01083220
119Neoplasm of the pancreas (HP:0002894)2.00881263
120Gastrointestinal atresia (HP:0002589)2.00585420
121Abnormality of the Achilles tendon (HP:0005109)2.00395497
122Diaphragmatic weakness (HP:0009113)1.99024694
123Oral leukoplakia (HP:0002745)1.98024635
124Lactic acidosis (HP:0003128)1.97436930
125Reticulocytosis (HP:0001923)1.97230436
126Difficulty climbing stairs (HP:0003551)1.96901847
127Neoplasm of striated muscle (HP:0009728)1.96806519
128Anteriorly placed anus (HP:0001545)1.95875930
129Pancreatic islet-cell hyperplasia (HP:0004510)1.95115663
130Limb-girdle muscle atrophy (HP:0003797)1.94055235
131Postnatal microcephaly (HP:0005484)1.93788623
132Atrophy/Degeneration involving motor neurons (HP:0007373)1.93515189
133Rough bone trabeculation (HP:0100670)1.93438328
134Joint stiffness (HP:0001387)1.92858118
135Myopathic facies (HP:0002058)1.91869332
136Bowed forearm bones (HP:0003956)1.91739326
137Bowing of the arm (HP:0006488)1.91739326
138Albinism (HP:0001022)1.91339013
139Abnormal gallbladder morphology (HP:0012437)1.90815800
140Abnormality of the ileum (HP:0001549)1.90657343
141Reticulocytopenia (HP:0001896)1.89973271
142Stridor (HP:0010307)1.89010541
143Premature rupture of membranes (HP:0001788)1.88822897
144Dysautonomia (HP:0002459)1.88767552
145Volvulus (HP:0002580)1.88186119
146Alopecia of scalp (HP:0002293)1.88171479
147Fasciculations (HP:0002380)1.87077504
148Hypoplastic pelvis (HP:0008839)1.86443620
149Hypoplasia of the radius (HP:0002984)1.85657952
150Spastic paraparesis (HP:0002313)1.84736539
151Abnormality of the gallbladder (HP:0005264)1.84705660
152Growth hormone excess (HP:0000845)1.84237748
153Pelvic girdle muscle weakness (HP:0003749)1.83815086
154Increased muscle lipid content (HP:0009058)1.83192083
155Emotional lability (HP:0000712)1.83149965
156Agnosia (HP:0010524)1.81922294
157Spinal muscular atrophy (HP:0007269)1.81778142
158Amaurosis fugax (HP:0100576)1.80961314
159Flat capital femoral epiphysis (HP:0003370)1.80926038
160Breast hypoplasia (HP:0003187)1.80735057
161Abnormal trabecular bone morphology (HP:0100671)1.80244795
162Bifid uvula (HP:0000193)1.78873243
163Type I transferrin isoform profile (HP:0003642)1.78331803
164Hepatic necrosis (HP:0002605)1.78199385
165Microretrognathia (HP:0000308)1.78197484
166Alacrima (HP:0000522)1.78187678
167Large for gestational age (HP:0001520)1.77970862
168Sparse eyelashes (HP:0000653)1.77687489
169Cerebral aneurysm (HP:0004944)1.77032925
170Premature ovarian failure (HP:0008209)1.76638446
171Increased CSF lactate (HP:0002490)1.75832434
172Mitochondrial inheritance (HP:0001427)1.75242511
173Abnormality of male internal genitalia (HP:0000022)1.75234938
174Renal duplication (HP:0000075)1.75177739
175Progressive microcephaly (HP:0000253)1.74929518
176Increased connective tissue (HP:0009025)1.74617540
177Retinal dysplasia (HP:0007973)1.74528883
178Reduced subcutaneous adipose tissue (HP:0003758)1.74367631
179Cortical dysplasia (HP:0002539)1.74129199
180Hypotelorism (HP:0000601)1.73989279
181Freckling (HP:0001480)1.73800699
182CNS hypomyelination (HP:0003429)1.73319608
183Abnormality of reticulocytes (HP:0004312)1.73230291
184Premature skin wrinkling (HP:0100678)1.73144997
185Biconcave vertebral bodies (HP:0004586)1.72327680
186Death in infancy (HP:0001522)1.72238174
187Birth length less than 3rd percentile (HP:0003561)1.72225540
188Trismus (HP:0000211)1.70984306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK3.68776442
2BUB13.58794959
3VRK23.39650831
4SMG13.13214561
5DDR22.97550428
6MAP3K62.93297270
7MAP3K112.87546566
8IRAK32.40296509
9MAPK152.38948230
10CDC72.35781135
11WEE12.33569295
12TESK22.27187847
13MAP3K101.99636290
14PBK1.92625450
15CDK71.91130048
16DAPK11.90703797
17TRIB31.89865362
18TYRO31.87089845
19UHMK11.87023623
20PIM21.85207362
21MATK1.81194951
22PASK1.76314021
23EEF2K1.75799168
24NEK21.73537496
25DYRK31.70926463
26NEK11.57822801
27PLK11.54411002
28TSSK61.52729724
29ARAF1.49087032
30CHEK21.40032110
31ATR1.38382320
32BMX1.37370710
33SIK11.34735110
34PRKD31.34565052
35EIF2AK11.32183072
36PINK11.32085401
37MST1R1.31233457
38DYRK1B1.29160255
39RPS6KB21.28079127
40PDGFRA1.22858085
41AURKA1.21217953
42LMTK21.18442861
43PAK41.13227735
44NME11.12990420
45NME21.12604667
46FGR1.11206749
47MAP4K11.08931086
48PIM11.07065907
49TESK11.04638320
50RPS6KL11.02792343
51RPS6KC11.02792343
52AURKB1.00376987
53PRKD20.99968014
54ACVR1B0.99944915
55TGFBR10.97503681
56BRSK10.97466209
57STK160.97422391
58PDK20.96723519
59TLK10.96584322
60PRPF4B0.94885368
61SCYL20.94853638
62MAP3K80.94753811
63TTK0.94393917
64CSK0.91321749
65PKN20.91060391
66CDK40.89812134
67RPS6KA60.89127197
68CDK60.88983469
69CSNK1A1L0.86577995
70YES10.85466077
71PAK10.85227955
72ERN10.83607531
73KDR0.82510615
74STK100.80824414
75PAK60.80674453
76MKNK10.79422035
77BRSK20.78126607
78CDK20.77537206
79CHEK10.77427619
80VRK10.77277536
81ILK0.77119942
82CCNB10.75229724
83ABL20.73684144
84MAPKAPK30.73007327
85MTOR0.72942120
86SIK30.72497383
87RPS6KA10.72087459
88MAPK110.71938631
89CDK120.71039195
90CLK10.70148255
91SRPK10.68731002
92LRRK20.65823566
93MET0.64712731
94CDC42BPA0.64219405
95LIMK10.62944497
96MAP2K70.62441619
97CDK11A0.61681964
98EPHA20.60754407
99TTN0.60132260
100RAF10.59978209
101MAP2K20.57864468
102CDK180.57357053
103AKT20.57107173
104CDK150.56965754
105PTK20.55454797
106ERBB40.55017771
107RPS6KA40.54947606
108IRAK20.54939590
109BRAF0.54537636
110CSNK1G20.54128335
111TAOK10.53691653
112TAOK20.53522052
113CSNK2A10.52998871
114ALK0.52709030
115ZAP700.52413028
116CSNK1G30.52060328
117CDK190.51524217
118MUSK0.50468484
119BCKDK0.50443635
120CAMK2G0.50258188
121LATS20.49309345
122PTK60.48310475
123CDK10.47873561
124CSNK1G10.47638387
125CSNK2A20.47242180
126CDK140.47196181
127ATM0.46819930
128MAPKAPK20.46701335
129DAPK30.45017047
130CDK90.44603565
131BTK0.43572795
132FGFR10.43258292
133PLK30.42030142
134CDK80.41835470
135PAK20.41303980
136RPS6KA50.39897505
137EPHB10.39771490
138PRKCI0.39106171
139EIF2AK20.38101808
140MAP3K30.35214364
141DYRK20.33922138
142BCR0.33474339

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.46361815
2Mismatch repair_Homo sapiens_hsa034305.07281005
3Base excision repair_Homo sapiens_hsa034104.26777365
4* Spliceosome_Homo sapiens_hsa030403.29949071
5Nucleotide excision repair_Homo sapiens_hsa034203.01960846
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01368251
7RNA transport_Homo sapiens_hsa030132.81766174
8Homologous recombination_Homo sapiens_hsa034402.58775732
9Cell cycle_Homo sapiens_hsa041102.55500585
10Proteasome_Homo sapiens_hsa030502.46644410
11Ribosome_Homo sapiens_hsa030102.33900015
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14618402
13Fatty acid elongation_Homo sapiens_hsa000622.06734685
14mRNA surveillance pathway_Homo sapiens_hsa030152.03145816
15RNA polymerase_Homo sapiens_hsa030201.97691242
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72137555
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66419331
18Fanconi anemia pathway_Homo sapiens_hsa034601.61292669
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59817964
20Pyrimidine metabolism_Homo sapiens_hsa002401.57609983
21p53 signaling pathway_Homo sapiens_hsa041151.55365876
22Notch signaling pathway_Homo sapiens_hsa043301.54596357
23One carbon pool by folate_Homo sapiens_hsa006701.46120187
24Biosynthesis of amino acids_Homo sapiens_hsa012301.45111887
25Oocyte meiosis_Homo sapiens_hsa041141.33499206
26Basal transcription factors_Homo sapiens_hsa030221.28940849
27Pyruvate metabolism_Homo sapiens_hsa006201.27294504
28RNA degradation_Homo sapiens_hsa030181.22868304
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21772189
30Parkinsons disease_Homo sapiens_hsa050121.21364977
31Vitamin B6 metabolism_Homo sapiens_hsa007501.21085672
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17755476
33Vibrio cholerae infection_Homo sapiens_hsa051101.17340203
34Hippo signaling pathway_Homo sapiens_hsa043901.14705855
35Fatty acid biosynthesis_Homo sapiens_hsa000611.14354066
36Oxidative phosphorylation_Homo sapiens_hsa001901.12506957
37Viral carcinogenesis_Homo sapiens_hsa052031.10263518
38Epstein-Barr virus infection_Homo sapiens_hsa051691.08535551
39Shigellosis_Homo sapiens_hsa051311.07263787
40mTOR signaling pathway_Homo sapiens_hsa041501.06796168
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04726253
42Bladder cancer_Homo sapiens_hsa052191.03041777
43Glutathione metabolism_Homo sapiens_hsa004801.01995588
44Steroid biosynthesis_Homo sapiens_hsa001001.01030753
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01020650
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00269674
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00221689
48Hedgehog signaling pathway_Homo sapiens_hsa043400.99696050
49Huntingtons disease_Homo sapiens_hsa050160.98853720
50Primary immunodeficiency_Homo sapiens_hsa053400.95221728
51Sulfur relay system_Homo sapiens_hsa041220.94413972
52Colorectal cancer_Homo sapiens_hsa052100.93731152
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93241854
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90975993
55HTLV-I infection_Homo sapiens_hsa051660.88871563
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87075381
57Non-homologous end-joining_Homo sapiens_hsa034500.84868524
58Chronic myeloid leukemia_Homo sapiens_hsa052200.82137852
59Other glycan degradation_Homo sapiens_hsa005110.79666972
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78907526
61Basal cell carcinoma_Homo sapiens_hsa052170.78359272
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74275222
63N-Glycan biosynthesis_Homo sapiens_hsa005100.73935700
64Folate biosynthesis_Homo sapiens_hsa007900.73793180
65Thyroid cancer_Homo sapiens_hsa052160.72368916
66Fatty acid metabolism_Homo sapiens_hsa012120.71977105
67Purine metabolism_Homo sapiens_hsa002300.71415566
68Arginine biosynthesis_Homo sapiens_hsa002200.71114460
69Phenylalanine metabolism_Homo sapiens_hsa003600.70600966
70Pentose phosphate pathway_Homo sapiens_hsa000300.69394134
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69041536
72Fructose and mannose metabolism_Homo sapiens_hsa000510.67731006
73MicroRNAs in cancer_Homo sapiens_hsa052060.67713444
74VEGF signaling pathway_Homo sapiens_hsa043700.66276485
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66140686
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65940055
77Selenocompound metabolism_Homo sapiens_hsa004500.64638142
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.64446869
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.62122547
80Alzheimers disease_Homo sapiens_hsa050100.61785228
81Systemic lupus erythematosus_Homo sapiens_hsa053220.60193699
82Adherens junction_Homo sapiens_hsa045200.58664708
83TGF-beta signaling pathway_Homo sapiens_hsa043500.58546547
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57996736
85Legionellosis_Homo sapiens_hsa051340.57660870
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57519764
87Wnt signaling pathway_Homo sapiens_hsa043100.55933585
88Metabolic pathways_Homo sapiens_hsa011000.55578397
89Antigen processing and presentation_Homo sapiens_hsa046120.55268791
90Arginine and proline metabolism_Homo sapiens_hsa003300.55125925
91Herpes simplex infection_Homo sapiens_hsa051680.54591523
92Acute myeloid leukemia_Homo sapiens_hsa052210.53990005
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51361255
94Sulfur metabolism_Homo sapiens_hsa009200.50790637
95Carbon metabolism_Homo sapiens_hsa012000.50710144
96Small cell lung cancer_Homo sapiens_hsa052220.50624293
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.49076354
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48301933
99Prion diseases_Homo sapiens_hsa050200.47673339
100Non-small cell lung cancer_Homo sapiens_hsa052230.47603604
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47448774
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46907894
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46527276
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46212387
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45449136
106Galactose metabolism_Homo sapiens_hsa000520.44572239
107Viral myocarditis_Homo sapiens_hsa054160.44403883
108Circadian rhythm_Homo sapiens_hsa047100.44156083
109Hepatitis B_Homo sapiens_hsa051610.44061798
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42392322
111Alcoholism_Homo sapiens_hsa050340.41865782
112Synaptic vesicle cycle_Homo sapiens_hsa047210.40659802
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.39875806
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39792336
115Salmonella infection_Homo sapiens_hsa051320.37034879
116Endometrial cancer_Homo sapiens_hsa052130.36038234
117Tight junction_Homo sapiens_hsa045300.35882207
118Apoptosis_Homo sapiens_hsa042100.35570837
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34927142
120Lysine degradation_Homo sapiens_hsa003100.34329930
121Tyrosine metabolism_Homo sapiens_hsa003500.33638777
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33573704
123HIF-1 signaling pathway_Homo sapiens_hsa040660.32314497
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.31724776
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31244794
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30892183
127Pathways in cancer_Homo sapiens_hsa052000.30863349
128Pancreatic cancer_Homo sapiens_hsa052120.28321994
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.26626432
130Gap junction_Homo sapiens_hsa045400.26470398
131Proteoglycans in cancer_Homo sapiens_hsa052050.25508962
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24106408
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21765915
134Insulin signaling pathway_Homo sapiens_hsa049100.21078668
135Endocytosis_Homo sapiens_hsa041440.20449875
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20439723
137Lysosome_Homo sapiens_hsa041420.20147519
138ErbB signaling pathway_Homo sapiens_hsa040120.19726227
139AMPK signaling pathway_Homo sapiens_hsa041520.19697481

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