PUM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.67974488
2nuclear pore complex assembly (GO:0051292)4.53015823
3mitotic sister chromatid cohesion (GO:0007064)3.95657375
4pre-miRNA processing (GO:0031054)3.87968361
5DNA unwinding involved in DNA replication (GO:0006268)3.76043190
6IMP biosynthetic process (GO:0006188)3.65359879
7regulation of histone H3-K9 methylation (GO:0051570)3.50106121
8negative regulation of histone methylation (GO:0031061)3.48185576
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.47372049
10cytoplasmic mRNA processing body assembly (GO:0033962)3.47004362
11negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.44534296
12negative regulation of translation, ncRNA-mediated (GO:0040033)3.44534296
13regulation of translation, ncRNA-mediated (GO:0045974)3.44534296
14glucocorticoid receptor signaling pathway (GO:0042921)3.32400999
15kinetochore organization (GO:0051383)3.32379732
16dosage compensation (GO:0007549)3.26907003
17regulation of helicase activity (GO:0051095)3.25349157
18regulation of posttranscriptional gene silencing (GO:0060147)3.25261657
19regulation of gene silencing by miRNA (GO:0060964)3.25261657
20regulation of gene silencing by RNA (GO:0060966)3.25261657
21pore complex assembly (GO:0046931)3.23013630
22paraxial mesoderm development (GO:0048339)3.22503361
23regulation of NFAT protein import into nucleus (GO:0051532)3.22117424
24DNA strand renaturation (GO:0000733)3.18948379
25mitotic nuclear envelope disassembly (GO:0007077)3.18175669
26spliceosomal tri-snRNP complex assembly (GO:0000244)3.17171402
27negative regulation of RNA splicing (GO:0033119)3.16596875
28negative regulation of mRNA processing (GO:0050686)3.16453579
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.12996700
30DNA topological change (GO:0006265)3.11888472
31mRNA splice site selection (GO:0006376)3.11795697
32DNA geometric change (GO:0032392)3.07665214
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.05789112
34somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05789112
35DNA duplex unwinding (GO:0032508)3.03387611
36protein-DNA complex disassembly (GO:0032986)3.02631229
37nucleosome disassembly (GO:0006337)3.02631229
38histone H3-K9 demethylation (GO:0033169)2.99204947
39nuclear envelope disassembly (GO:0051081)2.95003401
40membrane disassembly (GO:0030397)2.95003401
41embryonic retina morphogenesis in camera-type eye (GO:0060059)2.94859133
42histone H2A acetylation (GO:0043968)2.94247621
43pyrimidine nucleobase catabolic process (GO:0006208)2.91493719
44positive regulation of RNA splicing (GO:0033120)2.91262958
45IMP metabolic process (GO:0046040)2.90614169
46snRNA processing (GO:0016180)2.86686102
47histone H4-K12 acetylation (GO:0043983)2.84392129
48regulation of RNA export from nucleus (GO:0046831)2.84342042
49regulation of nucleobase-containing compound transport (GO:0032239)2.83611300
50protein localization to kinetochore (GO:0034501)2.82846789
51histone H3-K4 trimethylation (GO:0080182)2.82573310
52definitive hemopoiesis (GO:0060216)2.81822325
53negative regulation of DNA repair (GO:0045738)2.78164173
54DNA replication initiation (GO:0006270)2.77272057
55histone H4-K5 acetylation (GO:0043981)2.76215016
56histone H4-K8 acetylation (GO:0043982)2.76215016
57regulation of nuclear cell cycle DNA replication (GO:0033262)2.76205732
58nucleobase biosynthetic process (GO:0046112)2.75882184
59snRNA metabolic process (GO:0016073)2.75321679
60positive regulation of dendritic spine morphogenesis (GO:0061003)2.75222377
61DNA replication-dependent nucleosome organization (GO:0034723)2.75214103
62DNA replication-dependent nucleosome assembly (GO:0006335)2.75214103
63positive regulation of histone H3-K4 methylation (GO:0051571)2.74504530
64mitotic metaphase plate congression (GO:0007080)2.74143467
65negative regulation of histone modification (GO:0031057)2.73599903
66kinetochore assembly (GO:0051382)2.72913785
67mRNA transport (GO:0051028)2.72338526
68mRNA export from nucleus (GO:0006406)2.72141747
69regulation of histone methylation (GO:0031060)2.72009913
70metaphase plate congression (GO:0051310)2.71899266
71RNA export from nucleus (GO:0006405)2.70467289
72regulation of histone H3-K4 methylation (GO:0051569)2.70207966
73histone H3-K36 demethylation (GO:0070544)2.69982721
74replication fork processing (GO:0031297)2.69821656
75regulation of DNA endoreduplication (GO:0032875)2.69055903
76mitotic chromosome condensation (GO:0007076)2.68426994
77sister chromatid segregation (GO:0000819)2.68291116
78presynaptic membrane assembly (GO:0097105)2.67580936
79regulation of gene silencing (GO:0060968)2.66616029
80negative regulation of mRNA metabolic process (GO:1903312)2.66217179
81ATP-dependent chromatin remodeling (GO:0043044)2.65807378
82RNA splicing, via transesterification reactions (GO:0000375)2.65149871
83RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.64037531
84mRNA splicing, via spliceosome (GO:0000398)2.64037531
85regulation of mRNA splicing, via spliceosome (GO:0048024)2.62853306
86histone demethylation (GO:0016577)2.61976485
87positive regulation of histone methylation (GO:0031062)2.61450311
88stress granule assembly (GO:0034063)2.61400713
89negative regulation of chromatin modification (GO:1903309)2.60799281
90histone H2A monoubiquitination (GO:0035518)2.60411547
91histone lysine demethylation (GO:0070076)2.58754855
92negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.58701294
93embryonic process involved in female pregnancy (GO:0060136)2.58537180
94mismatch repair (GO:0006298)2.58402426
95protein demethylation (GO:0006482)2.57978352
96protein dealkylation (GO:0008214)2.57978352
97DNA conformation change (GO:0071103)2.57798709
98DNA replication-independent nucleosome organization (GO:0034724)2.57700881
99DNA replication-independent nucleosome assembly (GO:0006336)2.57700881
100positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.57259244
101positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.57259244
102positive regulation of mitotic sister chromatid separation (GO:1901970)2.57259244
103histone H2B ubiquitination (GO:0033523)2.56615934
104histone H3-K4 methylation (GO:0051568)2.56452761
105peptidyl-lysine trimethylation (GO:0018023)2.55670397
106positive regulation of chromosome segregation (GO:0051984)2.54512501
107regulation of spindle organization (GO:0090224)2.53891379
108chromatin remodeling at centromere (GO:0031055)2.53783536
109regulation of sister chromatid cohesion (GO:0007063)2.52549273
110chromatin assembly (GO:0031497)2.52218458
111DNA strand elongation involved in DNA replication (GO:0006271)2.51671672
112protein K6-linked ubiquitination (GO:0085020)2.50127055
113establishment of RNA localization (GO:0051236)2.49910637
114RNA localization (GO:0006403)2.49611522
115proximal/distal pattern formation (GO:0009954)2.47488464
116histone H4-K16 acetylation (GO:0043984)2.43608772
117monoubiquitinated protein deubiquitination (GO:0035520)2.43447777
118genitalia morphogenesis (GO:0035112)2.41260896
119neuronal stem cell maintenance (GO:0097150)2.40770611
120histone H3-K9 methylation (GO:0051567)2.39953394
121morphogenesis of an epithelial sheet (GO:0002011)2.39600614
122gastrulation with mouth forming second (GO:0001702)2.36872967
123regulation of centriole replication (GO:0046599)2.36734403
124positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.35315988
125establishment of nucleus localization (GO:0040023)2.33149312
126V(D)J recombination (GO:0033151)2.31523741
127embryonic foregut morphogenesis (GO:0048617)2.30164726
128presynaptic membrane organization (GO:0097090)2.28083330
129NLS-bearing protein import into nucleus (GO:0006607)2.27710364
130calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.27653608
131regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.26612907
132positive regulation of mRNA processing (GO:0050685)2.25750467
133dorsal/ventral axis specification (GO:0009950)2.24222048
134histone lysine methylation (GO:0034968)2.22041386
135embryonic camera-type eye morphogenesis (GO:0048596)2.21800346
136resolution of meiotic recombination intermediates (GO:0000712)2.21276772
137positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.20543750
138protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.19777723
139camera-type eye morphogenesis (GO:0048593)2.19460175
140positive regulation of mRNA 3-end processing (GO:0031442)2.18836758
141ectodermal placode formation (GO:0060788)2.17919964
142heart morphogenesis (GO:0003007)2.17721753
143G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.17309725
144notochord development (GO:0030903)2.17024199
145regulation of cAMP-dependent protein kinase activity (GO:2000479)2.16445198
146lens morphogenesis in camera-type eye (GO:0002089)2.16015840
147neurotransmitter-gated ion channel clustering (GO:0072578)2.15594462
148limb development (GO:0060173)2.14605304
149appendage development (GO:0048736)2.14605304
150nucleobase catabolic process (GO:0046113)2.13851515
151positive regulation of receptor biosynthetic process (GO:0010870)2.13112761
152regulation of DNA damage checkpoint (GO:2000001)2.12652288
153axonal fasciculation (GO:0007413)2.12575717
154apical protein localization (GO:0045176)2.12130390
155negative regulation of DNA recombination (GO:0045910)2.11168864
156negative regulation of translation (GO:0017148)2.10355684
157positive regulation of hormone biosynthetic process (GO:0046886)2.10240562
158regulation of mRNA 3-end processing (GO:0031440)2.09040109
159protein localization to microtubule (GO:0035372)2.07373803
160cerebral cortex development (GO:0021987)2.07357686
161nucleus localization (GO:0051647)2.06659145
162regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.05219406
163positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.05219406
164histone methylation (GO:0016571)2.05129122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.49461351
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.98803223
3* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.41294323
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.40411222
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.30164941
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.28759119
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.09586922
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02481666
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.96606529
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.90132865
11IGF1R_20145208_ChIP-Seq_DFB_Human2.79022936
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61556329
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38817282
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.31270885
15MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23070612
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.17108690
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11859534
18TAF15_26573619_Chip-Seq_HEK293_Human2.07778456
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06538313
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06538313
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06538313
22* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05580258
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.04458294
24E2F7_22180533_ChIP-Seq_HELA_Human10.7532588
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98251309
26* CIITA_25753668_ChIP-Seq_RAJI_Human1.97143583
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93814432
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92765757
29MYC_22102868_ChIP-Seq_BL_Human1.92044105
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90991127
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89994472
32SOX2_18555785_ChIP-Seq_MESCs_Mouse1.88354476
33GBX2_23144817_ChIP-Seq_PC3_Human1.87702996
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.84965209
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.81207678
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74007127
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.73147233
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71185823
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70950113
40AR_21572438_ChIP-Seq_LNCaP_Human1.68870393
41TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.63153619
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60737643
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59860797
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59848040
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59460111
46RNF2_27304074_Chip-Seq_NSC_Mouse1.54317867
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53008903
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52119810
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51183352
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.50125169
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.47238530
52* XRN2_22483619_ChIP-Seq_HELA_Human1.45992763
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45303212
54AR_21909140_ChIP-Seq_LNCAP_Human1.44323802
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43989196
56TCF3_18692474_ChIP-Seq_MESCs_Mouse1.42680016
57* SOX9_26525672_Chip-Seq_HEART_Mouse1.42218394
58* ELK1_19687146_ChIP-ChIP_HELA_Human1.40963223
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39293406
60SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.38729896
61YAP1_20516196_ChIP-Seq_MESCs_Mouse1.38295429
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37396611
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36515795
64SMAD4_21799915_ChIP-Seq_A2780_Human1.35924957
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35369707
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.35256450
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.33987059
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33761026
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33365093
70* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.32924669
71* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32213549
72* SOX2_16153702_ChIP-ChIP_HESCs_Human1.31477461
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31124424
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30720420
75FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30457258
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27962681
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27455663
78* TTF2_22483619_ChIP-Seq_HELA_Human1.27056984
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26404456
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24580959
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24152093
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.23889902
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23848834
84P300_19829295_ChIP-Seq_ESCs_Human1.23329477
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.22463203
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21968310
87TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20648399
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20607111
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20255602
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20180004
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20180004
92* STAT3_23295773_ChIP-Seq_U87_Human1.19066930
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17541760
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.17218670
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15937055
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15817519
97EWS_26573619_Chip-Seq_HEK293_Human1.15757813
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15570391
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15289573
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.15112468
101ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14540447
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13477335
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13167613
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13118771
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12784567
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12575399
107EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11824064
108POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11072031
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.09594676
110KDM5A_27292631_Chip-Seq_BREAST_Human1.09144345
111FUS_26573619_Chip-Seq_HEK293_Human1.08911609
112PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08176986
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07817604
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07385640
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05690368
116THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05232619
117GATA1_26923725_Chip-Seq_HPCs_Mouse1.04979700
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04944529
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03958954
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03524946
121TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03518283
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03398006
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02710496
124ZNF274_21170338_ChIP-Seq_K562_Hela1.02036867
125NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01971059
126VDR_23849224_ChIP-Seq_CD4+_Human1.01773211
127FOXP3_21729870_ChIP-Seq_TREG_Human1.01493719
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00447743
129* CHD1_26751641_Chip-Seq_LNCaP_Human0.97838161
130* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97480899
131CLOCK_20551151_ChIP-Seq_293T_Human0.96992802
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96929625
133POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.96760875
134SOX2_21211035_ChIP-Seq_LN229_Gbm0.96102296
135* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95702116
136TCF7_22412390_ChIP-Seq_EML_Mouse0.92931625
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92777244
138ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92239399
139CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91656821
140TCF4_23295773_ChIP-Seq_U87_Human0.90824567
141EZH2_27304074_Chip-Seq_ESCs_Mouse0.90127997
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89933893
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.89864187
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87362332
145NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87158387
146ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84981641
147SCL_19346495_ChIP-Seq_HPC-7_Human0.84825764
148* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.83161877
149FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82300327
150ISL1_27105846_Chip-Seq_CPCs_Mouse0.81997671
151ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81915837
152HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81390108
153STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80994514
154* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.80504431
155KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.77684740
156IRF1_19129219_ChIP-ChIP_H3396_Human0.77224764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.38326049
2MP0010094_abnormal_chromosome_stability3.03156691
3MP0003111_abnormal_nucleus_morphology2.80705840
4MP0003121_genomic_imprinting2.67177219
5MP0003123_paternal_imprinting2.60730647
6MP0008007_abnormal_cellular_replicative2.45405369
7MP0003077_abnormal_cell_cycle2.44389775
8MP0003693_abnormal_embryo_hatching2.43745494
9MP0000537_abnormal_urethra_morphology2.40070114
10MP0008877_abnormal_DNA_methylation2.32960846
11MP0010352_gastrointestinal_tract_polyps2.31620759
12MP0004957_abnormal_blastocyst_morpholog2.26777458
13MP0000778_abnormal_nervous_system2.14844604
14MP0000516_abnormal_urinary_system2.09454718
15MP0005367_renal/urinary_system_phenotyp2.09454718
16MP0003787_abnormal_imprinting2.09372762
17MP0010030_abnormal_orbit_morphology2.05055035
18MP0008058_abnormal_DNA_repair2.03247394
19MP0005187_abnormal_penis_morphology1.98194959
20MP0003890_abnormal_embryonic-extraembry1.97561589
21MP0009053_abnormal_anal_canal1.96889926
22MP0005076_abnormal_cell_differentiation1.92475822
23MP0006292_abnormal_olfactory_placode1.89954337
24MP0003122_maternal_imprinting1.78701621
25MP0003941_abnormal_skin_development1.76479181
26MP0004197_abnormal_fetal_growth/weight/1.71588358
27MP0002084_abnormal_developmental_patter1.71259216
28MP0001293_anophthalmia1.69803084
29MP0005380_embryogenesis_phenotype1.68122013
30MP0001672_abnormal_embryogenesis/_devel1.68122013
31MP0003119_abnormal_digestive_system1.67533816
32MP0000350_abnormal_cell_proliferation1.66012286
33MP0001730_embryonic_growth_arrest1.62105013
34MP0002085_abnormal_embryonic_tissue1.61374648
35MP0003984_embryonic_growth_retardation1.55926307
36MP0002088_abnormal_embryonic_growth/wei1.54620101
37MP0001299_abnormal_eye_distance/1.51614556
38MP0003567_abnormal_fetal_cardiomyocyte1.50247737
39MP0003786_premature_aging1.46914500
40MP0001697_abnormal_embryo_size1.46202304
41MP0003115_abnormal_respiratory_system1.41157826
42MP0008932_abnormal_embryonic_tissue1.40927881
43MP0002938_white_spotting1.40573192
44MP0002086_abnormal_extraembryonic_tissu1.40503961
45MP0002396_abnormal_hematopoietic_system1.40458319
46MP0000049_abnormal_middle_ear1.40365148
47MP0002249_abnormal_larynx_morphology1.38951931
48MP0000383_abnormal_hair_follicle1.36526036
49MP0002009_preneoplasia1.35627842
50MP0004808_abnormal_hematopoietic_stem1.34992196
51MP0003935_abnormal_craniofacial_develop1.34718288
52MP0001346_abnormal_lacrimal_gland1.34276048
53MP0003937_abnormal_limbs/digits/tail_de1.32956963
54MP0004270_analgesia1.30260495
55MP0003942_abnormal_urinary_system1.29291917
56MP0003755_abnormal_palate_morphology1.27403072
57MP0003315_abnormal_perineum_morphology1.27343882
58MP0003385_abnormal_body_wall1.26568850
59MP0002184_abnormal_innervation1.25620877
60MP0001286_abnormal_eye_development1.24701326
61MP0004859_abnormal_synaptic_plasticity1.24683552
62MP0001529_abnormal_vocalization1.24300008
63MP0004133_heterotaxia1.23539899
64MP0001984_abnormal_olfaction1.23508803
65MP0000678_abnormal_parathyroid_gland1.22665293
66MP0009703_decreased_birth_body1.22292793
67MP0008961_abnormal_basal_metabolism1.21347201
68MP0003880_abnormal_central_pattern1.20228072
69MP0005409_darkened_coat_color1.19904236
70MP0003943_abnormal_hepatobiliary_system1.19467330
71MP0000647_abnormal_sebaceous_gland1.18076507
72MP0000955_abnormal_spinal_cord1.17001236
73MP0002080_prenatal_lethality1.14827310
74MP0005394_taste/olfaction_phenotype1.13800403
75MP0005499_abnormal_olfactory_system1.13800403
76MP0006276_abnormal_autonomic_nervous1.12495223
77MP0003861_abnormal_nervous_system1.12090174
78MP0000579_abnormal_nail_morphology1.10359448
79MP0006054_spinal_hemorrhage1.10018729
80MP0000428_abnormal_craniofacial_morphol1.09572042
81MP0002152_abnormal_brain_morphology1.07672420
82MP0010307_abnormal_tumor_latency1.06767810
83MP0010678_abnormal_skin_adnexa1.06168192
84MP0005645_abnormal_hypothalamus_physiol1.05579220
85MP0002116_abnormal_craniofacial_bone1.05470372
86MP0000432_abnormal_head_morphology1.04321296
87MP0002092_abnormal_eye_morphology1.02302589
88MP0001177_atelectasis1.01542379
89MP0002925_abnormal_cardiovascular_devel0.99032078
90MP0004272_abnormal_basement_membrane0.98359853
91MP0004264_abnormal_extraembryonic_tissu0.96108578
92MP0004811_abnormal_neuron_physiology0.94872078
93MP0002697_abnormal_eye_size0.94676103
94MP0000534_abnormal_ureter_morphology0.94224650
95MP0002234_abnormal_pharynx_morphology0.93651805
96MP0005248_abnormal_Harderian_gland0.93636304
97MP0002653_abnormal_ependyma_morphology0.93398251
98MP0002751_abnormal_autonomic_nervous0.92281961
99MP0001188_hyperpigmentation0.92028607
100MP0002111_abnormal_tail_morphology0.91867376
101MP0009697_abnormal_copulation0.91178041
102MP0002233_abnormal_nose_morphology0.91030483
103MP0002114_abnormal_axial_skeleton0.90946842
104MP0003221_abnormal_cardiomyocyte_apopto0.90842661
105MP0003938_abnormal_ear_development0.90829374
106MP0002210_abnormal_sex_determination0.90350435
107MP0002081_perinatal_lethality0.90181009
108MP0005623_abnormal_meninges_morphology0.88713707
109MP0001502_abnormal_circadian_rhythm0.88218193
110MP0000631_abnormal_neuroendocrine_gland0.86453868
111MP0000569_abnormal_digit_pigmentation0.86152241
112MP0008995_early_reproductive_senescence0.85795742
113MP0010234_abnormal_vibrissa_follicle0.85788556
114MP0002932_abnormal_joint_morphology0.85566546
115MP0010630_abnormal_cardiac_muscle0.84646721
116MP0004134_abnormal_chest_morphology0.84044188
117MP0000003_abnormal_adipose_tissue0.83870387
118MP0005391_vision/eye_phenotype0.83699452
119MP0008789_abnormal_olfactory_epithelium0.83180465
120MP0000313_abnormal_cell_death0.82477946
121MP0009672_abnormal_birth_weight0.81693693
122MP0000566_synostosis0.80724622
123MP0002877_abnormal_melanocyte_morpholog0.79580066
124MP0000703_abnormal_thymus_morphology0.79356280
125MP0000490_abnormal_crypts_of0.77750070
126MP0001915_intracranial_hemorrhage0.74710123
127MP0001145_abnormal_male_reproductive0.74426696
128MP0002177_abnormal_outer_ear0.74086908
129MP0000733_abnormal_muscle_development0.72589967
130MP0000266_abnormal_heart_morphology0.72172844
131MP0002163_abnormal_gland_morphology0.71367442
132MP0002075_abnormal_coat/hair_pigmentati0.70769133

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.42266772
2Short 4th metacarpal (HP:0010044)3.42266772
3Volvulus (HP:0002580)3.28665391
4Abnormality of the labia minora (HP:0012880)3.26475886
5Ependymoma (HP:0002888)3.19717741
6Abnormality of the fingertips (HP:0001211)3.11629403
7Papillary thyroid carcinoma (HP:0002895)3.03888468
8Colon cancer (HP:0003003)3.03754632
9Medulloblastoma (HP:0002885)3.02864155
10Cortical dysplasia (HP:0002539)2.98211877
11Neoplasm of the oral cavity (HP:0100649)2.86813002
12Astrocytoma (HP:0009592)2.64263729
13Abnormality of the astrocytes (HP:0100707)2.64263729
14Aplasia/Hypoplasia of the sternum (HP:0006714)2.54812733
15Long eyelashes (HP:0000527)2.53626769
16Broad palm (HP:0001169)2.51358000
17Patellar aplasia (HP:0006443)2.47103251
18High anterior hairline (HP:0009890)2.46235706
19Midline defect of the nose (HP:0004122)2.45950507
20Abnormal number of incisors (HP:0011064)2.43557593
21Ectopic kidney (HP:0000086)2.43355464
22Abnormality of the 4th metacarpal (HP:0010012)2.38005946
23Intestinal atresia (HP:0011100)2.36091365
24Renal duplication (HP:0000075)2.35159907
25Glioma (HP:0009733)2.33266073
26Lip pit (HP:0100267)2.32887054
27Aplasia/Hypoplasia of the patella (HP:0006498)2.29601706
28Increased nuchal translucency (HP:0010880)2.27867674
29Chromsome breakage (HP:0040012)2.26960028
30Supernumerary ribs (HP:0005815)2.26192153
31Supernumerary spleens (HP:0009799)2.23662112
32Cutaneous finger syndactyly (HP:0010554)2.21558531
33Selective tooth agenesis (HP:0001592)2.19352017
34Shawl scrotum (HP:0000049)2.17489073
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16987508
36Rib fusion (HP:0000902)2.15667119
37Abnormal lung lobation (HP:0002101)2.15002424
38Supernumerary bones of the axial skeleton (HP:0009144)2.14413601
39Genetic anticipation (HP:0003743)2.11095650
40Cutaneous syndactyly (HP:0012725)2.09725934
41Drooling (HP:0002307)2.08819815
42Rhabdomyosarcoma (HP:0002859)2.05697701
43Birth length less than 3rd percentile (HP:0003561)2.03389769
44Sparse scalp hair (HP:0002209)2.01096273
4511 pairs of ribs (HP:0000878)2.00823090
46Proximal placement of thumb (HP:0009623)1.98717196
47Missing ribs (HP:0000921)1.98647954
48Abnormality of the nasal septum (HP:0000419)1.96010695
49Esophageal atresia (HP:0002032)1.95855108
50Skull defect (HP:0001362)1.93051194
51Neoplasm of the adrenal cortex (HP:0100641)1.92834781
52Deviation of the thumb (HP:0009603)1.92245426
53Abnormality of the aortic arch (HP:0012303)1.92175204
54Nephroblastoma (Wilms tumor) (HP:0002667)1.91880441
55Gastrointestinal atresia (HP:0002589)1.89862210
56Abnormality of the intervertebral disk (HP:0005108)1.89016044
57Neoplasm of striated muscle (HP:0009728)1.87130563
58Termporal pattern (HP:0011008)1.86535482
59Insidious onset (HP:0003587)1.86535482
60Anal stenosis (HP:0002025)1.86044173
61Spinal cord lesions (HP:0100561)1.85356554
62Syringomyelia (HP:0003396)1.85356554
63Neoplasm of the heart (HP:0100544)1.84228411
64Hepatoblastoma (HP:0002884)1.84113700
65Shoulder girdle muscle weakness (HP:0003547)1.83667716
66Thyroid carcinoma (HP:0002890)1.83664987
67Embryonal renal neoplasm (HP:0011794)1.83607436
68Deep philtrum (HP:0002002)1.82647848
69Trigonocephaly (HP:0000243)1.82007821
70Hyperacusis (HP:0010780)1.81816134
71Obsessive-compulsive behavior (HP:0000722)1.81649712
72Poor coordination (HP:0002370)1.80938456
73Meckel diverticulum (HP:0002245)1.79968285
74Omphalocele (HP:0001539)1.79935713
75Anophthalmia (HP:0000528)1.78369365
76Biliary tract neoplasm (HP:0100574)1.78298264
77Abnormality of the distal phalanx of the thumb (HP:0009617)1.78111883
78Excessive salivation (HP:0003781)1.77870103
79Gastrointestinal carcinoma (HP:0002672)1.77740742
80Malignant gastrointestinal tract tumors (HP:0006749)1.77740742
81Myelodysplasia (HP:0002863)1.77700818
82Tubulointerstitial nephritis (HP:0001970)1.77405649
83Intestinal fistula (HP:0100819)1.76030792
84Hypoplastic labia majora (HP:0000059)1.75928880
85Exercise-induced muscle cramps (HP:0003710)1.74727450
86Abnormality of the lower motor neuron (HP:0002366)1.74436338
87Amaurosis fugax (HP:0100576)1.74030966
88Abnormality of chromosome stability (HP:0003220)1.73814325
89Depressed nasal tip (HP:0000437)1.73671190
90Overlapping toe (HP:0001845)1.73423715
91Abnormality of the ileum (HP:0001549)1.73291802
92Broad alveolar ridges (HP:0000187)1.72481885
93Hypoplasia of the maxilla (HP:0000327)1.71643278
94Hypospadias (HP:0000047)1.71371813
95Atresia of the external auditory canal (HP:0000413)1.70998156
96Gonadotropin excess (HP:0000837)1.70816750
97Degeneration of anterior horn cells (HP:0002398)1.70693949
98Abnormality of the anterior horn cell (HP:0006802)1.70693949
99Urethral obstruction (HP:0000796)1.70566565
100Vertebral arch anomaly (HP:0008438)1.70347027
101Absent radius (HP:0003974)1.69775236
102Absent eyebrow (HP:0002223)1.69381917
103Facial hemangioma (HP:0000329)1.69308007
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.69037995
105Heterotopia (HP:0002282)1.68833811
106Agnosia (HP:0010524)1.68738792
107Aplasia involving bones of the extremities (HP:0009825)1.68481765
108Aplasia involving bones of the upper limbs (HP:0009823)1.68481765
109Aplasia of the phalanges of the hand (HP:0009802)1.68481765
110Absent thumb (HP:0009777)1.67607268
111Impulsivity (HP:0100710)1.67134111
112Truncal obesity (HP:0001956)1.66973936
113Abnormality of the columella (HP:0009929)1.66883534
114Sparse lateral eyebrow (HP:0005338)1.66673874
115Absent frontal sinuses (HP:0002688)1.66518910
116Abnormality of the parietal bone (HP:0002696)1.66015870
117Broad phalanges of the hand (HP:0009768)1.65922884
118Abnormality of the parathyroid morphology (HP:0011766)1.65575647
119Bronchomalacia (HP:0002780)1.64211154
120Abnormality of the antihelix (HP:0009738)1.64091577
121Alacrima (HP:0000522)1.63349488
122Curly hair (HP:0002212)1.63191811
123Broad finger (HP:0001500)1.63141787
124Spina bifida occulta (HP:0003298)1.62192317
125Renovascular hypertension (HP:0100817)1.62168227
126Abnormality of chromosome segregation (HP:0002916)1.61935103
127Abnormality of the hip-girdle musculature (HP:0001445)1.61789592
128Abnormality of the musculature of the pelvis (HP:0001469)1.61789592
129Labial hypoplasia (HP:0000066)1.61292781
130Decreased lacrimation (HP:0000633)1.59919472
131Optic nerve coloboma (HP:0000588)1.59640436
132Abnormality of the labia majora (HP:0012881)1.59628964
133Abnormality of abdominal situs (HP:0011620)1.58426421
134Abdominal situs inversus (HP:0003363)1.58426421
135Abnormality of the incisor (HP:0000676)1.58361999
136Skin tags (HP:0010609)1.58307633
137Vitreoretinal degeneration (HP:0000655)1.58258597
138Broad thumb (HP:0011304)1.57746166
139Pelvic girdle muscle weakness (HP:0003749)1.57687661
140Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.57626649
141Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57455833
142Hammertoe (HP:0001765)1.55834721
1432-3 toe syndactyly (HP:0004691)1.55342429
144Aqueductal stenosis (HP:0002410)1.54660878
145Vaginal atresia (HP:0000148)1.54517109
146Narrow palate (HP:0000189)1.53143892
147Morphological abnormality of the middle ear (HP:0008609)1.52772740
148Coarctation of aorta (HP:0001680)1.51492484
149Broad phalanx (HP:0006009)1.51389133
150Cystic hygroma (HP:0000476)1.51170853
151Oligodactyly (hands) (HP:0001180)1.50712041
152Tracheomalacia (HP:0002779)1.50596638
153Dysmetric saccades (HP:0000641)1.49328659
154Limited elbow extension (HP:0001377)1.48811846
155Broad foot (HP:0001769)1.48647078
156Exotropia (HP:0000577)1.48137456
157Genital tract atresia (HP:0001827)1.46541721
158Facial cleft (HP:0002006)1.46229638
159Pheochromocytoma (HP:0002666)1.46096211
160Macroorchidism (HP:0000053)1.45929978
161Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.45926716
162Abnormality of the pubic bones (HP:0003172)1.45783970
163Broad long bones (HP:0005622)1.45482015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.95736221
2BRD43.25689970
3MKNK13.07578333
4MKNK22.99176364
5CDC72.98666479
6TSSK62.80153513
7CAMK1G2.70084951
8WEE12.65311124
9SRPK12.37373861
10PASK2.35313837
11PLK32.26069076
12CAMK1D2.15432966
13AKT32.02366896
14MAP3K41.91445347
15EPHA21.88314849
16RPS6KB21.84341440
17ATR1.81906617
18CDK81.81850349
19EEF2K1.79377363
20CDK71.78913672
21ZAK1.78532653
22CASK1.77508054
23BRSK21.72978282
24TTK1.70234720
25TNIK1.61465005
26CHEK21.54316281
27TRIM281.53785869
28MAP4K21.51114244
29ERBB31.50471473
30NTRK21.48123187
31TGFBR11.41904278
32CHEK11.34168841
33NEK21.32541629
34CLK11.30889889
35STK31.30487987
36ATM1.29095588
37SGK4941.29030080
38SGK2231.29030080
39VRK11.26663463
40PLK11.23257388
41ACVR1B1.21142127
42CSNK1A1L1.15952669
43PNCK1.15552058
44MELK1.15214504
45STK41.14287164
46CDK21.13827449
47NLK1.09030175
48EPHB21.08807554
49FGFR41.08687588
50DYRK31.08075129
51FER1.07964101
52CSNK1G11.06954600
53AURKB1.03378353
54TYRO31.03280874
55ALK0.98958037
56MTOR0.96111814
57PLK40.94233926
58CDK60.94141946
59DYRK1B0.93346461
60EPHA40.93149525
61WNK30.90677905
62FGFR10.90157918
63SGK20.89445825
64CDK10.89108732
65PRKD30.88990714
66CHUK0.87921964
67CDK40.87768735
68SIK20.87350622
69CDK90.86145576
70NTRK10.85130624
71BUB10.84797024
72CSNK1G20.84329507
73RPS6KB10.83514970
74MAP3K90.82102651
75SGK30.78713523
76MAP2K70.78423686
77YES10.78422762
78CSNK1G30.78236338
79FGFR20.77990620
80CCNB10.77532625
81WNK10.77277198
82MAP3K60.76053593
83LATS10.76016748
84EPHA30.75736074
85RET0.73955364
86MAPK140.72914793
87MET0.72584800
88BRSK10.72544934
89SIK30.71681926
90PDGFRB0.70102331
91PRPF4B0.68863361
92MAPK100.68702433
93DMPK0.68378602
94STK38L0.68294990
95PIM10.67263556
96MAP3K100.67223495
97PLK20.66471809
98DYRK20.66462771
99GSK3B0.66267529
100CSNK1D0.65538161
101PRKAA10.65332916
102BMPR20.63542690
103PRKDC0.62554778
104FGFR30.61029488
105ERBB20.60963860
106BCR0.60899337
107STK240.60196919
108KSR10.58751953
109NTRK30.58637401
110RIPK10.58145767
111CAMK40.57799817
112MAPK130.57516071
113ICK0.57197933
114MAP3K70.55830004
115STK100.55407729
116CSNK1E0.55197302
117AKT10.54486409
118NUAK10.54467578
119MARK10.53676948
120MAPK80.53559402
121EIF2AK30.53146723
122LATS20.52702049
123RPS6KL10.50917640
124RPS6KC10.50917640
125MAPK10.50278316
126CSNK2A20.49850547
127MAP2K40.49106421
128SGK10.48588568
129MAP3K20.48106415
130KSR20.45971867
131NEK60.45881745
132DYRK1A0.45839098
133TXK0.45655883
134MAPK90.44995586
135TIE10.44989090
136PDGFRA0.44927991
137RPS6KA60.44815817
138MARK30.44734195
139FLT30.44567758
140TAF10.42572915
141PAK40.42172548
142CDK30.41618343
143RPS6KA40.41474264
144RPS6KA50.40931747
145UHMK10.39978662
146RPS6KA10.39970127

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.61506677
2DNA replication_Homo sapiens_hsa030303.01904823
3Spliceosome_Homo sapiens_hsa030403.00745076
4RNA transport_Homo sapiens_hsa030132.70609934
5Cell cycle_Homo sapiens_hsa041102.68611880
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66877209
7mRNA surveillance pathway_Homo sapiens_hsa030152.59107361
8RNA polymerase_Homo sapiens_hsa030202.25585209
9Base excision repair_Homo sapiens_hsa034102.21574035
10Fanconi anemia pathway_Homo sapiens_hsa034602.10430842
11Circadian rhythm_Homo sapiens_hsa047102.00643463
12Homologous recombination_Homo sapiens_hsa034402.00408996
13RNA degradation_Homo sapiens_hsa030181.93583306
14Nucleotide excision repair_Homo sapiens_hsa034201.93501286
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72840448
16Non-homologous end-joining_Homo sapiens_hsa034501.71735603
17One carbon pool by folate_Homo sapiens_hsa006701.69193845
18Basal cell carcinoma_Homo sapiens_hsa052171.68733989
19Basal transcription factors_Homo sapiens_hsa030221.61365046
20MicroRNAs in cancer_Homo sapiens_hsa052061.57134039
21Hippo signaling pathway_Homo sapiens_hsa043901.54457415
22Notch signaling pathway_Homo sapiens_hsa043301.52238558
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51846602
24p53 signaling pathway_Homo sapiens_hsa041151.45642966
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45293471
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40227186
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36732058
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35877447
29TGF-beta signaling pathway_Homo sapiens_hsa043501.33580776
30Colorectal cancer_Homo sapiens_hsa052101.32854021
31Nicotine addiction_Homo sapiens_hsa050331.31360688
32Adherens junction_Homo sapiens_hsa045201.27220683
33Hedgehog signaling pathway_Homo sapiens_hsa043401.25043108
34Viral carcinogenesis_Homo sapiens_hsa052031.24780997
35Wnt signaling pathway_Homo sapiens_hsa043101.24327531
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22997135
37Selenocompound metabolism_Homo sapiens_hsa004501.21808365
38Oocyte meiosis_Homo sapiens_hsa041141.21284810
39Pyrimidine metabolism_Homo sapiens_hsa002401.19269036
40Systemic lupus erythematosus_Homo sapiens_hsa053221.15648255
41HTLV-I infection_Homo sapiens_hsa051661.15560524
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10212877
43Long-term depression_Homo sapiens_hsa047301.07417814
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05476277
45Epstein-Barr virus infection_Homo sapiens_hsa051691.04830550
46Small cell lung cancer_Homo sapiens_hsa052221.04175265
47Prostate cancer_Homo sapiens_hsa052151.04137778
48Inositol phosphate metabolism_Homo sapiens_hsa005621.02232634
49Herpes simplex infection_Homo sapiens_hsa051681.00361422
50Chronic myeloid leukemia_Homo sapiens_hsa052201.00032281
51Endometrial cancer_Homo sapiens_hsa052130.99670236
52Steroid biosynthesis_Homo sapiens_hsa001000.99229148
53Type II diabetes mellitus_Homo sapiens_hsa049300.99225854
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98985625
55Thyroid cancer_Homo sapiens_hsa052160.98791635
56Pathways in cancer_Homo sapiens_hsa052000.95256320
57Alcoholism_Homo sapiens_hsa050340.94417812
58Fatty acid biosynthesis_Homo sapiens_hsa000610.94247228
59Choline metabolism in cancer_Homo sapiens_hsa052310.92135024
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91107203
61Cocaine addiction_Homo sapiens_hsa050300.90743198
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88235878
63Lysine degradation_Homo sapiens_hsa003100.85813272
64Insulin signaling pathway_Homo sapiens_hsa049100.85511625
65Thyroid hormone synthesis_Homo sapiens_hsa049180.84215997
66Gap junction_Homo sapiens_hsa045400.82591354
67Ribosome_Homo sapiens_hsa030100.82139417
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82035251
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81475488
70Non-small cell lung cancer_Homo sapiens_hsa052230.80170084
71Purine metabolism_Homo sapiens_hsa002300.79712268
72FoxO signaling pathway_Homo sapiens_hsa040680.78326909
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74474061
74Viral myocarditis_Homo sapiens_hsa054160.71544653
75Tight junction_Homo sapiens_hsa045300.71024627
76Axon guidance_Homo sapiens_hsa043600.70236682
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70219741
78Melanoma_Homo sapiens_hsa052180.69951756
79Antigen processing and presentation_Homo sapiens_hsa046120.68049953
80Pancreatic cancer_Homo sapiens_hsa052120.67253040
81Glutamatergic synapse_Homo sapiens_hsa047240.67103481
82mTOR signaling pathway_Homo sapiens_hsa041500.66877953
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66824913
84Taste transduction_Homo sapiens_hsa047420.66721511
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66600422
86Proteoglycans in cancer_Homo sapiens_hsa052050.66571013
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65664874
88Dorso-ventral axis formation_Homo sapiens_hsa043200.65514913
89Insulin secretion_Homo sapiens_hsa049110.64976117
90Propanoate metabolism_Homo sapiens_hsa006400.64726593
91Hepatitis B_Homo sapiens_hsa051610.63438437
92Circadian entrainment_Homo sapiens_hsa047130.62830511
93Melanogenesis_Homo sapiens_hsa049160.62690967
94Glioma_Homo sapiens_hsa052140.62611874
95Cholinergic synapse_Homo sapiens_hsa047250.61198627
96GABAergic synapse_Homo sapiens_hsa047270.61069015
97Acute myeloid leukemia_Homo sapiens_hsa052210.61010550
98Butanoate metabolism_Homo sapiens_hsa006500.59148325
99ErbB signaling pathway_Homo sapiens_hsa040120.58460544
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55227814
101Focal adhesion_Homo sapiens_hsa045100.55135987
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54373016
103T cell receptor signaling pathway_Homo sapiens_hsa046600.53498291
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53453913
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52668727
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.51812917
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.51081652
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.47310687
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46151714
110cAMP signaling pathway_Homo sapiens_hsa040240.45413118
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45372029
112Amphetamine addiction_Homo sapiens_hsa050310.45020244
113MAPK signaling pathway_Homo sapiens_hsa040100.44843824
114Rap1 signaling pathway_Homo sapiens_hsa040150.44597055
115HIF-1 signaling pathway_Homo sapiens_hsa040660.44213200
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43906279
117Renal cell carcinoma_Homo sapiens_hsa052110.42061668
118ECM-receptor interaction_Homo sapiens_hsa045120.41033260
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39315050
120AMPK signaling pathway_Homo sapiens_hsa041520.39084550
121Estrogen signaling pathway_Homo sapiens_hsa049150.39081261
122Dilated cardiomyopathy_Homo sapiens_hsa054140.38621328
123Glucagon signaling pathway_Homo sapiens_hsa049220.38528942
124Platelet activation_Homo sapiens_hsa046110.38238971
125Measles_Homo sapiens_hsa051620.38125013
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38082953
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35558362
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33942679
129Long-term potentiation_Homo sapiens_hsa047200.33093287
130Bladder cancer_Homo sapiens_hsa052190.33069437
131Phototransduction_Homo sapiens_hsa047440.32394820
132B cell receptor signaling pathway_Homo sapiens_hsa046620.31480598
133Dopaminergic synapse_Homo sapiens_hsa047280.31075360
134Shigellosis_Homo sapiens_hsa051310.30437060
135Prolactin signaling pathway_Homo sapiens_hsa049170.29987682
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.29669593
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28992959

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