PUM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.49194664
2nuclear pore complex assembly (GO:0051292)5.16590465
3nuclear pore organization (GO:0006999)4.73211620
4nerve growth factor signaling pathway (GO:0038180)4.64425659
5cytoplasmic mRNA processing body assembly (GO:0033962)4.49093493
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.45130669
7regulation of sister chromatid cohesion (GO:0007063)4.41256260
8phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.40472310
9negative regulation of histone methylation (GO:0031061)4.12008760
10protein localization to kinetochore (GO:0034501)4.03173732
11mitotic chromosome condensation (GO:0007076)4.01024713
12negative regulation of neurotransmitter secretion (GO:0046929)3.94135181
13pre-miRNA processing (GO:0031054)3.86615853
14pore complex assembly (GO:0046931)3.82194130
15regulation of RNA export from nucleus (GO:0046831)3.73145724
16regulation of DNA endoreduplication (GO:0032875)3.64336030
17DNA unwinding involved in DNA replication (GO:0006268)3.61798969
18mRNA modification (GO:0016556)3.60505149
19protein localization to chromosome, centromeric region (GO:0071459)3.42303780
20peptidyl-lysine dimethylation (GO:0018027)3.41402574
21histone H2A monoubiquitination (GO:0035518)3.38191009
22monoubiquitinated protein deubiquitination (GO:0035520)3.34913705
23DNA topological change (GO:0006265)3.32967839
24dosage compensation (GO:0007549)3.32181902
25glucocorticoid receptor signaling pathway (GO:0042921)3.31600115
26sister chromatid segregation (GO:0000819)3.29872548
27NLS-bearing protein import into nucleus (GO:0006607)3.28415154
28negative regulation of translation, ncRNA-mediated (GO:0040033)3.22217356
29regulation of translation, ncRNA-mediated (GO:0045974)3.22217356
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22217356
31regulation of nucleobase-containing compound transport (GO:0032239)3.21516993
32cellular response to nitric oxide (GO:0071732)3.18312663
33mRNA stabilization (GO:0048255)3.16896721
34RNA stabilization (GO:0043489)3.16896721
35neural tube formation (GO:0001841)3.14664415
36histone H3-K4 trimethylation (GO:0080182)3.12787212
37histone H3-K36 demethylation (GO:0070544)3.12311264
38negative regulation of dendrite morphogenesis (GO:0050774)3.09593594
39positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.08710402
40positive regulation of mitotic sister chromatid separation (GO:1901970)3.08710402
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.08710402
42corticosteroid receptor signaling pathway (GO:0031958)3.07476935
43DNA duplex unwinding (GO:0032508)3.07377760
44embryonic retina morphogenesis in camera-type eye (GO:0060059)3.05909961
45mitotic nuclear envelope disassembly (GO:0007077)3.05554136
46negative regulation of neurotransmitter transport (GO:0051589)3.05239888
47DNA geometric change (GO:0032392)3.04916680
48regulation of histone H3-K9 methylation (GO:0051570)3.04440803
49regulation of spindle organization (GO:0090224)3.03873532
50nuclear envelope disassembly (GO:0051081)3.02894745
51membrane disassembly (GO:0030397)3.02894745
52negative regulation of dendrite development (GO:2000171)3.01777008
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01659960
54protein localization to chromosome (GO:0034502)2.98910955
55regulation of pigment cell differentiation (GO:0050932)2.97182678
56peptidyl-lysine trimethylation (GO:0018023)2.97105840
57regulation of NFAT protein import into nucleus (GO:0051532)2.95467257
58chromatin assembly (GO:0031497)2.94978931
59embryonic camera-type eye morphogenesis (GO:0048596)2.87501115
60response to nitric oxide (GO:0071731)2.87131863
61forebrain morphogenesis (GO:0048853)2.84191362
62cellular response to reactive nitrogen species (GO:1902170)2.82079212
63cellular response to ethanol (GO:0071361)2.81958105
64Rap protein signal transduction (GO:0032486)2.80151875
65positive regulation of chromosome segregation (GO:0051984)2.78391955
66histone H3-K9 demethylation (GO:0033169)2.76328869
67regulation of mitotic spindle organization (GO:0060236)2.75657436
68nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.75120491
69regulation of mRNA stability (GO:0043488)2.73795312
70RNA destabilization (GO:0050779)2.72107547
71alternative mRNA splicing, via spliceosome (GO:0000380)2.70715975
723-UTR-mediated mRNA stabilization (GO:0070935)2.69890959
73sister chromatid cohesion (GO:0007062)2.66853873
74translesion synthesis (GO:0019985)2.65806209
75negative regulation of histone modification (GO:0031057)2.64279485
76regulation of centriole replication (GO:0046599)2.61267265
77negative regulation of RNA splicing (GO:0033119)2.60836435
78heterochromatin organization (GO:0070828)2.60601618
79histone mRNA catabolic process (GO:0071044)2.60433295
80presynaptic membrane assembly (GO:0097105)2.60324899
81nuclear envelope organization (GO:0006998)2.60049094
82histone H3-K4 methylation (GO:0051568)2.59255789
83nucleus organization (GO:0006997)2.58851595
84histone-serine phosphorylation (GO:0035404)2.58785718
85histone H4-K16 acetylation (GO:0043984)2.58270871
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.58219846
87regulation of RNA stability (GO:0043487)2.56838700
88centriole replication (GO:0007099)2.56443778
89chromatin assembly or disassembly (GO:0006333)2.56071565
90positive regulation of histone deacetylation (GO:0031065)2.54883921
91DNA conformation change (GO:0071103)2.54442899
92mitotic sister chromatid segregation (GO:0000070)2.53835955
93positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.53406477
94regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.53406477
95positive regulation of cell size (GO:0045793)2.51525427
96positive T cell selection (GO:0043368)2.51512033
97chromosome condensation (GO:0030261)2.51504731
98positive regulation of granulocyte differentiation (GO:0030854)2.50063247
99positive regulation of insulin receptor signaling pathway (GO:0046628)2.48168422
100regulation of histone methylation (GO:0031060)2.47754895
101lens morphogenesis in camera-type eye (GO:0002089)2.46049220
102negative regulation of chromatin modification (GO:1903309)2.45652017
103histone phosphorylation (GO:0016572)2.44873554
104regulation of histone H3-K27 methylation (GO:0061085)2.43970716
105mRNA splice site selection (GO:0006376)2.43565116
106regulation of energy homeostasis (GO:2000505)2.43464334
107regulation of transforming growth factor beta2 production (GO:0032909)2.42719100
108attachment of spindle microtubules to kinetochore (GO:0008608)2.42600965
109cellular response to nerve growth factor stimulus (GO:1990090)2.41436834
110response to nerve growth factor (GO:1990089)2.41436834
111antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.41080325
112negative thymic T cell selection (GO:0045060)2.40550017
113regulation of chromosome segregation (GO:0051983)2.40339637
114positive regulation of gamma-delta T cell activation (GO:0046645)2.39958682
115germ cell migration (GO:0008354)2.39936527
116definitive hemopoiesis (GO:0060216)2.39192008
117histone lysine demethylation (GO:0070076)2.38993567
118gene silencing by RNA (GO:0031047)2.38403416
119positive regulation of gene expression, epigenetic (GO:0045815)2.37499189
120positive regulation of mRNA catabolic process (GO:0061014)2.37380381
121mitotic metaphase plate congression (GO:0007080)2.37306123
122negative regulation of DNA repair (GO:0045738)2.36855562
123regulation of translational termination (GO:0006449)2.36187822
124central nervous system projection neuron axonogenesis (GO:0021952)2.36002349
125metaphase plate congression (GO:0051310)2.34961024
126protein dealkylation (GO:0008214)2.34648496
127protein demethylation (GO:0006482)2.34648496
128negative T cell selection (GO:0043383)2.34255532
129negative regulation of histone acetylation (GO:0035067)2.31664994
130dorsal/ventral axis specification (GO:0009950)2.31504774
131megakaryocyte development (GO:0035855)2.31424504
132histone H3-K9 methylation (GO:0051567)2.30720648
133peptidyl-lysine methylation (GO:0018022)2.30168495
134ventricular system development (GO:0021591)2.29461146
135interkinetic nuclear migration (GO:0022027)2.29003903
136regulation of Rac protein signal transduction (GO:0035020)2.28745472
137V(D)J recombination (GO:0033151)2.28234664
138histone lysine methylation (GO:0034968)2.27466124
139histone H4 acetylation (GO:0043967)2.27276714
140peptidyl-threonine phosphorylation (GO:0018107)2.26864691
141protein localization to microtubule (GO:0035372)2.26688182
142regulation of Rap GTPase activity (GO:0032317)2.26521362
143histone H3-K9 modification (GO:0061647)2.26339795
144DNA packaging (GO:0006323)2.25217226
145peptidyl-threonine modification (GO:0018210)2.25000392
146microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.24825101
147histone demethylation (GO:0016577)2.24655768
148positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.24612415
149regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.24612415
150mitochondrion distribution (GO:0048311)2.24234876
151Leydig cell differentiation (GO:0033327)2.23717383
152glial cell proliferation (GO:0014009)2.22833201
153ATP-dependent chromatin remodeling (GO:0043044)2.22382646
154gene silencing (GO:0016458)2.22189362
155regulation of mRNA catabolic process (GO:0061013)2.21923224
156spindle checkpoint (GO:0031577)2.21504314
157regulation of growth hormone secretion (GO:0060123)2.20559155
158regulation of gamma-delta T cell differentiation (GO:0045586)2.19985438
159positive regulation of Rap GTPase activity (GO:0032854)2.19976219
160presynaptic membrane organization (GO:0097090)2.19431138
161Golgi to endosome transport (GO:0006895)2.18565308
162genitalia morphogenesis (GO:0035112)2.18277045
163embryonic process involved in female pregnancy (GO:0060136)2.16843226
164establishment of nucleus localization (GO:0040023)2.15865201
165lymphoid progenitor cell differentiation (GO:0002320)2.14995330
166trophectodermal cell differentiation (GO:0001829)2.14374895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.40614871
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.56539349
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.52939461
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.05067305
5MYC_22102868_ChIP-Seq_BL_Human3.62914303
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41921752
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.07782642
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.93498291
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79991065
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.78170715
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.54447024
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49172497
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39963410
14* E2F1_21310950_ChIP-Seq_MCF-7_Human2.37324249
15TCF7_22412390_ChIP-Seq_EML_Mouse2.34416090
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32513451
17* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.05274684
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04146449
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00937360
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99005251
21* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.97927219
22TAF15_26573619_Chip-Seq_HEK293_Human1.94311728
23AR_21909140_ChIP-Seq_LNCAP_Human1.92916769
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91847230
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85131807
26* KDM2B_26808549_Chip-Seq_DND41_Human1.85099620
27FUS_26573619_Chip-Seq_HEK293_Human1.84720004
28* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81891420
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81882480
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81471410
31VDR_21846776_ChIP-Seq_THP-1_Human1.80662336
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77093185
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76181282
34* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.75205297
35GBX2_23144817_ChIP-Seq_PC3_Human1.70126353
36IGF1R_20145208_ChIP-Seq_DFB_Human1.67644657
37MYB_26560356_Chip-Seq_TH2_Human1.66280751
38SCL_19346495_ChIP-Seq_HPC-7_Human1.65858052
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.65001080
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64911146
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62546122
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61046946
43CIITA_25753668_ChIP-Seq_RAJI_Human1.59491871
44MAF_26560356_Chip-Seq_TH1_Human1.58897539
45* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.58054567
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57963236
47UTX_26944678_Chip-Seq_JUKART_Human1.55733321
48* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54111764
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.53899458
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52494994
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51826826
52MYB_26560356_Chip-Seq_TH1_Human1.51768609
53STAT3_23295773_ChIP-Seq_U87_Human1.51072164
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.48394373
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.47562230
56SMAD4_21799915_ChIP-Seq_A2780_Human1.47134624
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47103067
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46637564
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44936919
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.43419150
61EWS_26573619_Chip-Seq_HEK293_Human1.42885770
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.42872783
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.42837518
64FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.42449328
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.40243615
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.39674067
67AHR_22903824_ChIP-Seq_MCF-7_Human1.38743788
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38580774
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37773304
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37184807
71AR_21572438_ChIP-Seq_LNCaP_Human1.36996310
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.36792118
73* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35951635
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.34536067
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32265484
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32173019
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31729778
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30827526
79RUNX_20019798_ChIP-Seq_JUKART_Human1.30036403
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.28543027
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28275117
82P300_19829295_ChIP-Seq_ESCs_Human1.28102954
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.27786189
84FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.26984431
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26668322
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25314847
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25199786
88ER_23166858_ChIP-Seq_MCF-7_Human1.24064535
89* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23755125
90VDR_24763502_ChIP-Seq_THP-1_Human1.22825297
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20993637
92ZNF263_19887448_ChIP-Seq_K562_Human1.19841253
93VDR_24787735_ChIP-Seq_THP-1_Human1.19782269
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18891714
95TCF4_23295773_ChIP-Seq_U87_Human1.18431163
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16990574
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16949114
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16622165
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16611589
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16414756
101* CHD1_26751641_Chip-Seq_LNCaP_Human1.16098380
102SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15182169
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14398235
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14322476
105KDM5A_27292631_Chip-Seq_BREAST_Human1.14254909
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14240678
107NCOR1_26117541_ChIP-Seq_K562_Human1.13527886
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13302419
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.13155120
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.12854298
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.12405787
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12064499
113* BRD4_25478319_ChIP-Seq_HGPS_Human1.11612643
114P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11486933
115GATA1_22025678_ChIP-Seq_K562_Human1.11411192
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11232031
117P53_22387025_ChIP-Seq_ESCs_Mouse1.09858841
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09155979
119CLOCK_20551151_ChIP-Seq_293T_Human1.08618423
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06354405
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06142898
122KDM2B_26808549_Chip-Seq_REH_Human1.03474921
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03345458
124IRF8_22096565_ChIP-ChIP_GC-B_Human1.02631255
125RUNX1_22412390_ChIP-Seq_EML_Mouse1.02603348
126PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02220600
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01386091
128GATA3_27048872_Chip-Seq_THYMUS_Human1.01047672
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00957532
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99731864
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99615873
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99400040
133SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98726944
134LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98709801
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98135849
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98135849
137ELK3_25401928_ChIP-Seq_HUVEC_Human0.97869458
138CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97839923
139NFE2_27457419_Chip-Seq_LIVER_Mouse0.97646697
140CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97247515
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97203932
142SPI1_23127762_ChIP-Seq_K562_Human0.96937216
143SOX2_21211035_ChIP-Seq_LN229_Gbm0.96242244
144OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94619158
145IRF8_27001747_Chip-Seq_BMDM_Mouse0.93617314
146* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92875509
147MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92229261
148E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90880409
149FOXO3_23340844_ChIP-Seq_DLD1_Human0.90547420
150SPI1_23547873_ChIP-Seq_NB4_Human0.88822928
151* KDM2B_26808549_Chip-Seq_K562_Human0.88313388
152NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87659405
153ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87033224
154MYC_18555785_ChIP-Seq_MESCs_Mouse0.86874618
155EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86762255
156IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85302824
157ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85280593
158KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85234885
159* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84851811
160E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84113645
161YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84112003
162PU_27001747_Chip-Seq_BMDM_Mouse0.83876448
163* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83635137
164UBF1/2_26484160_Chip-Seq_HMECs_Human0.83561855
165NANOG_21062744_ChIP-ChIP_HESCs_Human0.82488471
166* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82379030
167ATF3_27146783_Chip-Seq_COLON_Human0.81602466
168TP53_16413492_ChIP-PET_HCT116_Human0.81496860
169SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80712486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.63281215
2MP0005409_darkened_coat_color3.53162861
3MP0010234_abnormal_vibrissa_follicle3.51030362
4MP0001188_hyperpigmentation3.32376862
5MP0010352_gastrointestinal_tract_polyps3.26042816
6MP0005076_abnormal_cell_differentiation2.95045370
7MP0010307_abnormal_tumor_latency2.85232528
8MP0003300_gastrointestinal_ulcer2.66694636
9MP0002396_abnormal_hematopoietic_system2.53457301
10MP0004808_abnormal_hematopoietic_stem2.42928682
11MP0002877_abnormal_melanocyte_morpholog2.42663976
12MP0003111_abnormal_nucleus_morphology2.37636633
13MP0010094_abnormal_chromosome_stability2.37382617
14MP0003705_abnormal_hypodermis_morpholog2.34882460
15MP0003077_abnormal_cell_cycle2.21640620
16MP0009278_abnormal_bone_marrow2.20825278
17MP0009697_abnormal_copulation2.13842902
18MP0008057_abnormal_DNA_replication2.13087873
19MP0003303_peritoneal_inflammation2.12564435
20MP0002166_altered_tumor_susceptibility2.11511713
21MP0003183_abnormal_peptide_metabolism1.98999887
22MP0006054_spinal_hemorrhage1.95698320
23MP0003123_paternal_imprinting1.94591954
24MP0003787_abnormal_imprinting1.85207436
25MP0008961_abnormal_basal_metabolism1.84304338
26MP0003121_genomic_imprinting1.81352289
27MP0002006_tumorigenesis1.80993406
28MP0003656_abnormal_erythrocyte_physiolo1.73793604
29MP0008007_abnormal_cellular_replicative1.73522545
30MP0001730_embryonic_growth_arrest1.71907255
31MP0004957_abnormal_blastocyst_morpholog1.68889358
32MP0001177_atelectasis1.66620519
33MP0000350_abnormal_cell_proliferation1.66528773
34MP0000733_abnormal_muscle_development1.64959253
35MP0003890_abnormal_embryonic-extraembry1.64360853
36MP0005397_hematopoietic_system_phenotyp1.64099895
37MP0001545_abnormal_hematopoietic_system1.64099895
38MP0002009_preneoplasia1.62026113
39MP0001849_ear_inflammation1.56727097
40MP0003693_abnormal_embryo_hatching1.55798253
41MP0000537_abnormal_urethra_morphology1.55613171
42MP0002086_abnormal_extraembryonic_tissu1.53803593
43MP0003567_abnormal_fetal_cardiomyocyte1.48389128
44MP0000015_abnormal_ear_pigmentation1.48175485
45MP0002084_abnormal_developmental_patter1.46321257
46MP0004197_abnormal_fetal_growth/weight/1.43629686
47MP0005380_embryogenesis_phenotype1.43287505
48MP0001672_abnormal_embryogenesis/_devel1.43287505
49MP0003984_embryonic_growth_retardation1.42852292
50MP0003763_abnormal_thymus_physiology1.42692214
51MP0002088_abnormal_embryonic_growth/wei1.42573264
52MP0003221_abnormal_cardiomyocyte_apopto1.39677990
53MP0000703_abnormal_thymus_morphology1.39241588
54MP0002398_abnormal_bone_marrow1.34300391
55MP0001697_abnormal_embryo_size1.33108529
56MP0005187_abnormal_penis_morphology1.27164985
57MP0004043_abnormal_pH_regulation1.27041783
58MP0000490_abnormal_crypts_of1.23551284
59MP0000778_abnormal_nervous_system1.22621694
60MP0003252_abnormal_bile_duct1.18529955
61MP0002085_abnormal_embryonic_tissue1.17731052
62MP0009703_decreased_birth_body1.16208544
63MP0000428_abnormal_craniofacial_morphol1.15059948
64MP0008877_abnormal_DNA_methylation1.13558812
65MP0002080_prenatal_lethality1.13135091
66MP0010678_abnormal_skin_adnexa1.09890935
67MP0005220_abnormal_exocrine_pancreas1.09532964
68MP0008995_early_reproductive_senescence1.08897404
69MP0009672_abnormal_birth_weight1.07786737
70MP0002925_abnormal_cardiovascular_devel1.07778028
71MP0003566_abnormal_cell_adhesion1.06962060
72MP0000465_gastrointestinal_hemorrhage1.03354445
73MP0003724_increased_susceptibility_to1.02910720
74MP0002098_abnormal_vibrissa_morphology1.00802231
75MP0003943_abnormal_hepatobiliary_system0.98509789
76MP0001851_eye_inflammation0.98470730
77MP0003868_abnormal_feces_composition0.98326194
78MP0002019_abnormal_tumor_incidence0.97192624
79MP0000383_abnormal_hair_follicle0.95780168
80MP0002722_abnormal_immune_system0.95351560
81MP0001800_abnormal_humoral_immune0.95048916
82MP0000427_abnormal_hair_cycle0.94446293
83MP0003935_abnormal_craniofacial_develop0.93840819
84MP0001915_intracranial_hemorrhage0.93413262
85MP0004885_abnormal_endolymph0.91943329
86MP0005310_abnormal_salivary_gland0.91815342
87MP0003880_abnormal_central_pattern0.91356700
88MP0003091_abnormal_cell_migration0.91017109
89MP0003448_altered_tumor_morphology0.90381182
90MP0009115_abnormal_fat_cell0.89651855
91MP0001879_abnormal_lymphatic_vessel0.89606175
92MP0003122_maternal_imprinting0.89361256
93MP0000716_abnormal_immune_system0.88487557
94MP0001835_abnormal_antigen_presentation0.87629899
95MP0004381_abnormal_hair_follicle0.87014418
96MP0008058_abnormal_DNA_repair0.86846685
97MP0003861_abnormal_nervous_system0.85972975
98MP0005367_renal/urinary_system_phenotyp0.85077716
99MP0000516_abnormal_urinary_system0.85077716
100MP0000689_abnormal_spleen_morphology0.83373563
101MP0004185_abnormal_adipocyte_glucose0.82845349
102MP0001286_abnormal_eye_development0.82063093
103MP0002452_abnormal_antigen_presenting0.81209176
104MP0002420_abnormal_adaptive_immunity0.81140561
105MP0004264_abnormal_extraembryonic_tissu0.81059705
106MP0000371_diluted_coat_color0.80640831
107MP0005671_abnormal_response_to0.80260026
108MP0000313_abnormal_cell_death0.79921449
109MP0009053_abnormal_anal_canal0.79610386
110MP0010630_abnormal_cardiac_muscle0.79464105
111MP0003115_abnormal_respiratory_system0.79104004
112MP0001819_abnormal_immune_cell0.79072393
113MP0002092_abnormal_eye_morphology0.78687305
114MP0000685_abnormal_immune_system0.78461281
115MP0002928_abnormal_bile_duct0.78391762
116MP0002429_abnormal_blood_cell0.78173369
117MP0000003_abnormal_adipose_tissue0.76593625
118MP0002796_impaired_skin_barrier0.76278474
119MP0000266_abnormal_heart_morphology0.75423937
120MP0005248_abnormal_Harderian_gland0.75134381
121MP0003755_abnormal_palate_morphology0.74884892
122MP0004270_analgesia0.74755649
123MP0001784_abnormal_fluid_regulation0.74682412
124MP0000432_abnormal_head_morphology0.74347643
125MP0002095_abnormal_skin_pigmentation0.71506498
126MP0008770_decreased_survivor_rate0.70727240
127MP0003937_abnormal_limbs/digits/tail_de0.70256246
128MP0005621_abnormal_cell_physiology0.69759024
129MP0010155_abnormal_intestine_physiology0.68390464
130MP0005174_abnormal_tail_pigmentation0.68312884
131MP0003119_abnormal_digestive_system0.68142638
132MP0003690_abnormal_glial_cell0.67286601
133MP0004782_abnormal_surfactant_physiolog0.66541206
134MP0001984_abnormal_olfaction0.66460277
135MP0005075_abnormal_melanosome_morpholog0.64675757
136MP0000377_abnormal_hair_follicle0.64547960
137MP0004811_abnormal_neuron_physiology0.64073095
138MP0002133_abnormal_respiratory_system0.63690072
139MP0005388_respiratory_system_phenotype0.63690072
140MP0004947_skin_inflammation0.63680661
141MP0002127_abnormal_cardiovascular_syste0.63652424
142MP0001943_abnormal_respiration0.63489186
143MP0001191_abnormal_skin_condition0.62510318

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.94550018
2Abnormality of the fingertips (HP:0001211)3.58318348
3Subacute progressive viral hepatitis (HP:0006572)3.56394902
4Papilledema (HP:0001085)3.33623336
5Hyperacusis (HP:0010780)3.15760671
6Macroorchidism (HP:0000053)3.06603207
7Thyroid carcinoma (HP:0002890)3.00862943
8Increased nuchal translucency (HP:0010880)2.99641055
9Curly hair (HP:0002212)2.92896980
10Short 4th metacarpal (HP:0010044)2.86377719
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.86377719
12Amyotrophic lateral sclerosis (HP:0007354)2.85248746
13Colon cancer (HP:0003003)2.83471334
14Rhabdomyosarcoma (HP:0002859)2.70258745
15Cystic hygroma (HP:0000476)2.54855825
16Enlarged penis (HP:0000040)2.51943883
17Conjunctival telangiectasia (HP:0000524)2.47722218
18Rectal prolapse (HP:0002035)2.39765090
19Long clavicles (HP:0000890)2.34933466
20Hematochezia (HP:0002573)2.32569103
21Thyroiditis (HP:0100646)2.29848553
22Elfin facies (HP:0004428)2.28870881
23Transitional cell carcinoma of the bladder (HP:0006740)2.28865008
24Gastrointestinal carcinoma (HP:0002672)2.27595384
25Malignant gastrointestinal tract tumors (HP:0006749)2.27595384
26Papillary thyroid carcinoma (HP:0002895)2.26404325
27Viral hepatitis (HP:0006562)2.24455856
28Long eyelashes (HP:0000527)2.23913300
29Truncal obesity (HP:0001956)2.22924687
30Disinhibition (HP:0000734)2.22328716
31Arterial tortuosity (HP:0005116)2.20176732
32Obsessive-compulsive behavior (HP:0000722)2.20077056
33Absent frontal sinuses (HP:0002688)2.19539398
34Inappropriate behavior (HP:0000719)2.18575766
35Renovascular hypertension (HP:0100817)2.18300572
36Acute myeloid leukemia (HP:0004808)2.17187774
37Syringomyelia (HP:0003396)2.16877337
38Spinal cord lesions (HP:0100561)2.16877337
39Astrocytoma (HP:0009592)2.15941633
40Abnormality of the astrocytes (HP:0100707)2.15941633
41Prominent nose (HP:0000448)2.15636383
42Abnormality of the lower motor neuron (HP:0002366)2.14498526
43Lower limb asymmetry (HP:0100559)2.12572713
44Renal duplication (HP:0000075)2.12078874
45Neoplasm of striated muscle (HP:0009728)2.11737283
46Cerebral aneurysm (HP:0004944)2.10830716
47Asymmetry of the thorax (HP:0001555)2.10033465
48Narrow palate (HP:0000189)2.08446126
49Bladder neoplasm (HP:0009725)2.07137014
50Bladder carcinoma (HP:0002862)2.07137014
51Increased density of long bones (HP:0006392)2.07007845
52Nephroblastoma (Wilms tumor) (HP:0002667)2.05808964
53Absent speech (HP:0001344)2.05788583
54Testicular neoplasm (HP:0010788)2.05017709
55Deviation of the thumb (HP:0009603)2.04992528
56Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.02974408
57Pointed chin (HP:0000307)2.01401420
58Cutaneous melanoma (HP:0012056)2.00738620
59Proximal placement of thumb (HP:0009623)1.99502490
60Bowel diverticulosis (HP:0005222)1.98653709
61Leiomyosarcoma (HP:0100243)1.98183433
62Uterine leiomyosarcoma (HP:0002891)1.98183433
63High pitched voice (HP:0001620)1.98071669
64Embryonal renal neoplasm (HP:0011794)1.98028219
65Shallow orbits (HP:0000586)1.97578652
66Vertebral arch anomaly (HP:0008438)1.97403117
67Overriding aorta (HP:0002623)1.97174868
68Broad palm (HP:0001169)1.96948425
69Abnormality of the 4th metacarpal (HP:0010012)1.96727812
70Cutis marmorata (HP:0000965)1.95313119
71Severe combined immunodeficiency (HP:0004430)1.94891663
72Tubulointerstitial nephritis (HP:0001970)1.94702352
73Heterotopia (HP:0002282)1.94686406
74Ankyloglossia (HP:0010296)1.92644064
75Relative macrocephaly (HP:0004482)1.91010020
76Midline defect of the nose (HP:0004122)1.90461954
77Hepatoblastoma (HP:0002884)1.90213939
78Excessive salivation (HP:0003781)1.89345160
79Hyperventilation (HP:0002883)1.88871643
80Diastasis recti (HP:0001540)1.88783153
81Medulloblastoma (HP:0002885)1.87820514
82Drooling (HP:0002307)1.87503128
83Thick eyebrow (HP:0000574)1.87478737
84Neoplasm of the adrenal cortex (HP:0100641)1.87039528
85Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84574532
86Biliary tract neoplasm (HP:0100574)1.83596850
87Exotropia (HP:0000577)1.82716355
88Ependymoma (HP:0002888)1.82207825
89Aqueductal stenosis (HP:0002410)1.81671320
90Germ cell neoplasia (HP:0100728)1.81546200
91Basal cell carcinoma (HP:0002671)1.81492740
92Flat acetabular roof (HP:0003180)1.81431021
93Abnormality of chromosome segregation (HP:0002916)1.81026689
94Neonatal hypoglycemia (HP:0001998)1.80624719
95Neoplasm of the oral cavity (HP:0100649)1.80432710
96Abnormality of oral frenula (HP:0000190)1.80196322
97Protruding tongue (HP:0010808)1.79917320
98Abnormality of incisor morphology (HP:0011063)1.79747035
99Recurrent viral infections (HP:0004429)1.79086593
100Facial hemangioma (HP:0000329)1.79035240
101Febrile seizures (HP:0002373)1.78492357
102Subaortic stenosis (HP:0001682)1.77599710
103Abnormality of the left ventricular outflow tract (HP:0011103)1.77599710
104Deep philtrum (HP:0002002)1.77547363
105Pelvic girdle muscle weakness (HP:0003749)1.77114211
106Bicuspid aortic valve (HP:0001647)1.76866390
107Tented upper lip vermilion (HP:0010804)1.76341551
108Fair hair (HP:0002286)1.76295253
109Sandal gap (HP:0001852)1.75802258
110Abnormality of T cell number (HP:0011839)1.75605546
111Trigonocephaly (HP:0000243)1.75512886
112Low anterior hairline (HP:0000294)1.74951908
113Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74745670
114Insomnia (HP:0100785)1.73484353
115Hyperkalemia (HP:0002153)1.71437343
116IgM deficiency (HP:0002850)1.69561455
117Vascular tortuosity (HP:0004948)1.68467654
118Cellulitis (HP:0100658)1.68052795
119T lymphocytopenia (HP:0005403)1.66867395
120Widely spaced teeth (HP:0000687)1.66527375
121Persistence of primary teeth (HP:0006335)1.66387480
122Urethral obstruction (HP:0000796)1.66214044
123Thickened calvaria (HP:0002684)1.65444322
124Aortic aneurysm (HP:0004942)1.65315362
125Large earlobe (HP:0009748)1.64841172
126Uterine neoplasm (HP:0010784)1.64530169
127Hallux valgus (HP:0001822)1.63379143
128Mitral valve prolapse (HP:0001634)1.62782456
129Megalencephaly (HP:0001355)1.62714879
130Flat cornea (HP:0007720)1.62406984
131Glioma (HP:0009733)1.61844431
132Coarse hair (HP:0002208)1.60973914
133B lymphocytopenia (HP:0010976)1.60151104
134Cafe-au-lait spot (HP:0000957)1.59775492
135Hamartoma (HP:0010566)1.59463585
136Renal cell carcinoma (HP:0005584)1.58817343
137Broad thumb (HP:0011304)1.58037046
138Abnormality of chromosome stability (HP:0003220)1.57740243
139Hip dysplasia (HP:0001385)1.57580126
140Myelodysplasia (HP:0002863)1.57564281
141Metaphyseal cupping (HP:0003021)1.57417998
142Chest pain (HP:0100749)1.57375503
143Cupped ear (HP:0000378)1.56991995
144Deviation of the hallux (HP:0010051)1.56805860
145Anal stenosis (HP:0002025)1.56740194
146Generalized hypopigmentation of hair (HP:0011358)1.56690307
147Gonadal dysgenesis (HP:0000133)1.56466404
148Gastroesophageal reflux (HP:0002020)1.55379494
149Combined immunodeficiency (HP:0005387)1.55089181
150Blepharitis (HP:0000498)1.54984282
151Micronodular cirrhosis (HP:0001413)1.54599894
152Intestinal atresia (HP:0011100)1.54456505
153Exostoses (HP:0100777)1.54411989
154Somatic mutation (HP:0001428)1.54313421
155Hypoplasia of the maxilla (HP:0000327)1.53641613
156Fibrous tissue neoplasm (HP:0012316)1.53166508
157Dilatation of the ascending aorta (HP:0005111)1.53051846
158Intestinal polyposis (HP:0200008)1.52412555
159Hypoplastic iliac wings (HP:0002866)1.52207062
160Acute lymphatic leukemia (HP:0006721)1.51930491
161Osteolytic defects of the hand bones (HP:0009699)1.51802268
162Abnormality of salivation (HP:0100755)1.51402753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.75652767
2NLK3.48362974
3PKN23.02236278
4TRIB32.86256300
5CDC72.85562039
6YES12.70662432
7NEK22.54606831
8CDK122.52608800
9MAP3K102.51258344
10AKT32.08649910
11CDK62.05466598
12BCR2.00077429
13SGK2231.97770597
14SGK4941.97770597
15LATS11.97465299
16CDK31.93500089
17CASK1.75060155
18RIPK11.68999624
19SCYL21.67234308
20ALK1.64466269
21FGFR31.64247234
22PDGFRA1.62587822
23PTK61.58924251
24CAMK1G1.55050146
25CAMK1D1.50716706
26STK31.45591918
27TAF11.44315133
28STK101.43523452
29CAMKK21.43238821
30EIF2AK31.41204523
31MAP4K11.38515167
32PASK1.33257324
33NEK11.30813293
34TGFBR11.29359561
35CDK41.26973479
36NTRK31.25742490
37JAK31.24140910
38RPS6KA41.22342928
39DYRK1A1.18758710
40PRPF4B1.18702250
41PDGFRB1.17902079
42WEE11.17893120
43NUAK11.17216603
44TTN1.14635564
45BRD41.14454111
46ERBB31.12786401
47MAP2K31.11205635
48FGFR41.10994840
49ATR1.08812509
50TTK1.08311164
51CSNK1A1L1.07681240
52RPS6KB21.07379499
53FRK1.06718465
54MELK1.06560958
55HIPK21.06359049
56CHEK11.05415078
57CAMKK11.01844216
58RET1.01083129
59CCNB11.00015626
60BRSK20.98569010
61LRRK20.97315113
62SGK30.95024794
63SRPK10.94207597
64MAPK70.93611011
65DMPK0.93315063
66MARK10.93061931
67MAP3K60.92265642
68MTOR0.92229919
69STK40.92134724
70NEK60.90781959
71IRAK10.90477149
72MAP3K80.90248811
73CDK90.88519364
74ATM0.87970124
75MAP3K140.87889433
76BTK0.87059021
77MKNK10.86449887
78FLT30.86428107
79TYRO30.86247128
80AURKB0.85932346
81CDK190.82686445
82PNCK0.82139467
83SGK10.81355964
84SIK20.81102948
85FGFR20.79948309
86PIM10.79819836
87WNK30.78399439
88CHUK0.77675943
89TGFBR20.76875422
90BRSK10.75575070
91CSF1R0.74514780
92PLK30.74268493
93EPHA30.74027861
94TAOK10.73844623
95* CDK20.73425990
96PAK40.73153236
97SIK30.72947091
98FGFR10.72875862
99SMG10.72354279
100MAP3K40.72101983
101CSNK1D0.71467772
102JAK10.71023724
103MAPK130.70333149
104TNIK0.69910015
105WNK10.69839210
106JAK20.69716264
107CAMK40.69319967
108KSR20.69234710
109PAK20.68033845
110ITK0.67871145
111IKBKE0.67395584
112MAP2K40.67376667
113CSNK1G20.66592196
114KSR10.64568520
115STK240.63930460
116CSNK1G10.63863025
117MAP3K20.62399432
118EPHA40.61905253
119ZAP700.61802357
120CHEK20.60804360
121DYRK30.59474294
122NTRK20.58765093
123RPS6KB10.58409636
124MAP3K70.57849449
125CLK10.57782373
126MAPK100.57759441
127TAOK30.57701435
128ACVR1B0.56976724
129SGK20.56899632
130TSSK60.55057974
131PLK20.55031559
132HCK0.54725664
133CSNK1G30.54300377
134UHMK10.53771553
135RIPK40.53125992
136MKNK20.51241693
137CDK10.51064733
138PRKCH0.50950469
139TYK20.50480619
140PRKD30.49844078
141STK110.49606510
142PLK10.48844003
143MAP3K90.48726151
144PRKDC0.47556634
145BMX0.47328498
146IRAK20.41981088
147EIF2AK20.39700811
148PLK40.36953695
149NEK90.36448800
150PIK3CA0.35637224
151GSK3B0.34849469
152TRIM280.34668176
153CSK0.34218594
154STK390.34126116

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052201.88021638
2Cell cycle_Homo sapiens_hsa041101.76013282
3MicroRNAs in cancer_Homo sapiens_hsa052061.50013926
4Colorectal cancer_Homo sapiens_hsa052101.48863360
5mTOR signaling pathway_Homo sapiens_hsa041501.47459183
6Small cell lung cancer_Homo sapiens_hsa052221.44715531
7Endometrial cancer_Homo sapiens_hsa052131.43114047
8Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.43112471
9Choline metabolism in cancer_Homo sapiens_hsa052311.39996677
10Non-small cell lung cancer_Homo sapiens_hsa052231.39837353
11Long-term depression_Homo sapiens_hsa047301.38315492
12mRNA surveillance pathway_Homo sapiens_hsa030151.36812367
13B cell receptor signaling pathway_Homo sapiens_hsa046621.35627383
14DNA replication_Homo sapiens_hsa030301.34070642
15Pancreatic cancer_Homo sapiens_hsa052121.29520624
16Neurotrophin signaling pathway_Homo sapiens_hsa047221.27604602
17RNA transport_Homo sapiens_hsa030131.26218052
18Adherens junction_Homo sapiens_hsa045201.24741033
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23938155
20Glioma_Homo sapiens_hsa052141.20959573
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17632169
22Dorso-ventral axis formation_Homo sapiens_hsa043201.15035441
23Viral carcinogenesis_Homo sapiens_hsa052031.13876736
24HTLV-I infection_Homo sapiens_hsa051661.13711085
25Circadian rhythm_Homo sapiens_hsa047101.13627296
26Viral myocarditis_Homo sapiens_hsa054161.12690144
27Oocyte meiosis_Homo sapiens_hsa041141.12514673
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12244319
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11828291
30Hepatitis B_Homo sapiens_hsa051611.10807502
31Proteoglycans in cancer_Homo sapiens_hsa052051.10152894
32Osteoclast differentiation_Homo sapiens_hsa043801.09696676
33T cell receptor signaling pathway_Homo sapiens_hsa046601.08631969
34Leishmaniasis_Homo sapiens_hsa051401.08225862
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08184476
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06882163
37Toxoplasmosis_Homo sapiens_hsa051451.05978823
38Acute myeloid leukemia_Homo sapiens_hsa052211.05663834
39Platelet activation_Homo sapiens_hsa046111.04832521
40Prolactin signaling pathway_Homo sapiens_hsa049171.03901120
41Mismatch repair_Homo sapiens_hsa034301.03637327
42Thyroid cancer_Homo sapiens_hsa052161.02818074
43Antigen processing and presentation_Homo sapiens_hsa046121.02198440
44FoxO signaling pathway_Homo sapiens_hsa040681.01777004
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.00729686
46p53 signaling pathway_Homo sapiens_hsa041151.00228481
47Prostate cancer_Homo sapiens_hsa052150.99732380
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.99007805
49Herpes simplex infection_Homo sapiens_hsa051680.98980931
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97922328
51Renin secretion_Homo sapiens_hsa049240.97808124
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.96157523
53Spliceosome_Homo sapiens_hsa030400.93890038
54Primary immunodeficiency_Homo sapiens_hsa053400.92742121
55Hepatitis C_Homo sapiens_hsa051600.92157169
56Type II diabetes mellitus_Homo sapiens_hsa049300.91940355
57Renal cell carcinoma_Homo sapiens_hsa052110.91686438
58Amphetamine addiction_Homo sapiens_hsa050310.91534684
59Focal adhesion_Homo sapiens_hsa045100.91481218
60Glutamatergic synapse_Homo sapiens_hsa047240.91451839
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91217835
62TNF signaling pathway_Homo sapiens_hsa046680.90818333
63Base excision repair_Homo sapiens_hsa034100.90664321
64Lysine degradation_Homo sapiens_hsa003100.89943590
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.89391812
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88829397
67Measles_Homo sapiens_hsa051620.88339652
68TGF-beta signaling pathway_Homo sapiens_hsa043500.88041665
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87427982
70VEGF signaling pathway_Homo sapiens_hsa043700.87059923
71Insulin resistance_Homo sapiens_hsa049310.86031139
72Estrogen signaling pathway_Homo sapiens_hsa049150.85691393
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85177529
74Chemokine signaling pathway_Homo sapiens_hsa040620.84215318
75RNA degradation_Homo sapiens_hsa030180.82803252
76Cholinergic synapse_Homo sapiens_hsa047250.82471193
77Hippo signaling pathway_Homo sapiens_hsa043900.81996699
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81825515
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81623546
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80683053
81Taste transduction_Homo sapiens_hsa047420.79656994
82Long-term potentiation_Homo sapiens_hsa047200.78500394
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77963078
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.77737564
85Non-homologous end-joining_Homo sapiens_hsa034500.77212846
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75665049
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75507947
88ErbB signaling pathway_Homo sapiens_hsa040120.75359993
89Pathways in cancer_Homo sapiens_hsa052000.75097775
90Glucagon signaling pathway_Homo sapiens_hsa049220.74732710
91Apoptosis_Homo sapiens_hsa042100.74605766
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.74373295
93Influenza A_Homo sapiens_hsa051640.73029986
94African trypanosomiasis_Homo sapiens_hsa051430.72680082
95Notch signaling pathway_Homo sapiens_hsa043300.71740940
96Gap junction_Homo sapiens_hsa045400.71509038
97Shigellosis_Homo sapiens_hsa051310.71006069
98Inositol phosphate metabolism_Homo sapiens_hsa005620.70488935
99MAPK signaling pathway_Homo sapiens_hsa040100.70143744
100Melanogenesis_Homo sapiens_hsa049160.70127506
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69998263
102Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67859535
103Circadian entrainment_Homo sapiens_hsa047130.67051663
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66832541
105Epstein-Barr virus infection_Homo sapiens_hsa051690.66272673
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.66265936
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65666192
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65622192
109HIF-1 signaling pathway_Homo sapiens_hsa040660.65262184
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65121451
111Systemic lupus erythematosus_Homo sapiens_hsa053220.64893034
112Wnt signaling pathway_Homo sapiens_hsa043100.64290546
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62180249
114Insulin signaling pathway_Homo sapiens_hsa049100.62016733
115Dopaminergic synapse_Homo sapiens_hsa047280.61828808
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61755137
117Thyroid hormone synthesis_Homo sapiens_hsa049180.61089719
118Rap1 signaling pathway_Homo sapiens_hsa040150.61058072
119AMPK signaling pathway_Homo sapiens_hsa041520.60057339
120Alcoholism_Homo sapiens_hsa050340.59869089
121Tuberculosis_Homo sapiens_hsa051520.59363561
122Fanconi anemia pathway_Homo sapiens_hsa034600.59316177
123Endocytosis_Homo sapiens_hsa041440.59091115
124cAMP signaling pathway_Homo sapiens_hsa040240.58929123
125GnRH signaling pathway_Homo sapiens_hsa049120.58868655
126Cocaine addiction_Homo sapiens_hsa050300.58768260
127Oxytocin signaling pathway_Homo sapiens_hsa049210.58669922
128Ras signaling pathway_Homo sapiens_hsa040140.57332770
129Axon guidance_Homo sapiens_hsa043600.54954324
130Fatty acid biosynthesis_Homo sapiens_hsa000610.52833299
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52479434
132Melanoma_Homo sapiens_hsa052180.51717617
133Hedgehog signaling pathway_Homo sapiens_hsa043400.48927573

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