PURB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72600537
2locomotory exploration behavior (GO:0035641)5.65001872
3synaptic vesicle maturation (GO:0016188)5.64124190
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.40350959
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.07423278
6synaptic vesicle exocytosis (GO:0016079)5.04897685
7vocalization behavior (GO:0071625)4.95988277
8glutamate secretion (GO:0014047)4.94251979
9regulation of synaptic vesicle exocytosis (GO:2000300)4.75737026
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.69525736
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.60132193
12regulation of glutamate receptor signaling pathway (GO:1900449)4.43041335
13neuronal action potential propagation (GO:0019227)4.35474440
14layer formation in cerebral cortex (GO:0021819)4.30177734
15protein localization to synapse (GO:0035418)4.23645554
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.20928219
17cellular potassium ion homeostasis (GO:0030007)4.20809811
18exploration behavior (GO:0035640)4.18348858
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.18326818
20neurotransmitter secretion (GO:0007269)4.11638513
21regulation of synaptic vesicle transport (GO:1902803)4.07387630
22regulation of neuronal synaptic plasticity (GO:0048168)4.03198169
23dendritic spine morphogenesis (GO:0060997)3.91222706
24sodium ion export (GO:0071436)3.88603156
25nuclear pore complex assembly (GO:0051292)3.87720609
26glutamate receptor signaling pathway (GO:0007215)3.83680556
27neuron cell-cell adhesion (GO:0007158)3.80402648
28regulation of synapse structural plasticity (GO:0051823)3.77197379
29synaptic transmission, glutamatergic (GO:0035249)3.74862831
30long-term memory (GO:0007616)3.74190097
31neuron-neuron synaptic transmission (GO:0007270)3.71361318
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69991928
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67931304
34regulation of dendritic spine morphogenesis (GO:0061001)3.57723392
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56520314
36gamma-aminobutyric acid transport (GO:0015812)3.56167402
37protein localization to endosome (GO:0036010)3.53195963
38activation of protein kinase A activity (GO:0034199)3.51935422
39long-term synaptic potentiation (GO:0060291)3.51918438
40positive regulation of membrane potential (GO:0045838)3.49666773
41regulation of postsynaptic membrane potential (GO:0060078)3.49491580
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.48897748
43regulation of nucleobase-containing compound transport (GO:0032239)3.45365484
44proline transport (GO:0015824)3.45077114
45regulation of RNA export from nucleus (GO:0046831)3.43366451
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.38355911
47regulation of synaptic plasticity (GO:0048167)3.38327308
48neurotransmitter-gated ion channel clustering (GO:0072578)3.37836914
49focal adhesion assembly (GO:0048041)3.35596935
50cell-substrate adherens junction assembly (GO:0007045)3.35596935
51cerebellar Purkinje cell differentiation (GO:0021702)3.32090257
52neurotransmitter transport (GO:0006836)3.31125581
53neuromuscular process controlling balance (GO:0050885)3.28258334
54vesicle transport along microtubule (GO:0047496)3.28174581
55adherens junction assembly (GO:0034333)3.27492603
56cytoskeletal anchoring at plasma membrane (GO:0007016)3.26205868
57regulation of NFAT protein import into nucleus (GO:0051532)3.25889162
58embryonic process involved in female pregnancy (GO:0060136)3.24187161
59regulation of clathrin-mediated endocytosis (GO:2000369)3.23490245
60regulation of neurotransmitter secretion (GO:0046928)3.22858181
61positive regulation of synapse maturation (GO:0090129)3.18260684
62mating behavior (GO:0007617)3.18217185
63response to histamine (GO:0034776)3.16014015
64neuron recognition (GO:0008038)3.15699838
65transmission of nerve impulse (GO:0019226)3.14997602
66regulation of histone H3-K27 methylation (GO:0061085)3.14827860
67negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13640843
68dendrite morphogenesis (GO:0048813)3.12746310
69regulation of ARF protein signal transduction (GO:0032012)3.12225512
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.12193435
71hypotonic response (GO:0006971)3.10109607
72synaptic vesicle endocytosis (GO:0048488)3.09659694
73regulation of voltage-gated calcium channel activity (GO:1901385)3.08854640
74axonal fasciculation (GO:0007413)3.08193744
75regulation of dendritic spine development (GO:0060998)3.06498776
76establishment of nucleus localization (GO:0040023)3.05860774
77L-amino acid import (GO:0043092)3.05451656
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05367706
79cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05288012
80cell-substrate junction assembly (GO:0007044)3.04876105
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.04817137
82cerebellar granule cell differentiation (GO:0021707)3.03330536
83negative regulation of fatty acid transport (GO:2000192)3.01921457
84prepulse inhibition (GO:0060134)3.01798120
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01145202
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.01008144
87nuclear pore organization (GO:0006999)2.99713488
88positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.99411688
89innervation (GO:0060384)2.99028465
90regulation of neurotransmitter levels (GO:0001505)2.98276172
91regulation of neurotransmitter transport (GO:0051588)2.97950422
92long term synaptic depression (GO:0060292)2.95949237
93regulation of vesicle fusion (GO:0031338)2.95790886
94membrane hyperpolarization (GO:0060081)2.95134648
95positive regulation of neurotransmitter transport (GO:0051590)2.94359667
96auditory behavior (GO:0031223)2.94243448
97cytoplasmic mRNA processing body assembly (GO:0033962)2.92730441
98membrane depolarization (GO:0051899)2.92260645
99potassium ion import (GO:0010107)2.91998533
100negative regulation of erythrocyte differentiation (GO:0045647)2.91116353
101regulation of glucose import in response to insulin stimulus (GO:2001273)2.90791580
102positive regulation of neurotransmitter secretion (GO:0001956)2.90413823
103regulation of early endosome to late endosome transport (GO:2000641)2.89210031
104regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.86413736
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84956547
106dendritic spine organization (GO:0097061)2.83813599
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.81671545
108positive regulation of synaptic transmission (GO:0050806)2.81487765
109response to auditory stimulus (GO:0010996)2.81391755
110synapse assembly (GO:0007416)2.81326755
111presynaptic membrane assembly (GO:0097105)2.79658774
112intraspecies interaction between organisms (GO:0051703)2.78583764
113social behavior (GO:0035176)2.78583764
114cell communication by electrical coupling (GO:0010644)2.78404817
115potassium ion homeostasis (GO:0055075)2.77891213
116embryonic camera-type eye morphogenesis (GO:0048596)2.77672943
117behavioral fear response (GO:0001662)2.76912396
118behavioral defense response (GO:0002209)2.76912396
119membrane depolarization during action potential (GO:0086010)2.76541535
120learning (GO:0007612)2.76445666
121organelle transport along microtubule (GO:0072384)2.76420803
122postsynaptic membrane organization (GO:0001941)2.74276252
123insulin-like growth factor receptor signaling pathway (GO:0048009)2.71945098
124positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.70785036
125epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68032586
126peptidyl-threonine phosphorylation (GO:0018107)2.67310084
127positive regulation of protein export from nucleus (GO:0046827)2.67108814
128peptidyl-threonine modification (GO:0018210)2.65773185
129pore complex assembly (GO:0046931)2.63068799
130regulation of transforming growth factor beta2 production (GO:0032909)2.62761233
131mitotic chromosome condensation (GO:0007076)2.57343581
132desmosome organization (GO:0002934)2.55959769
133negative regulation of neurotransmitter secretion (GO:0046929)2.55580488
134skin morphogenesis (GO:0043589)2.54308981
135regulation of mitotic spindle organization (GO:0060236)2.53778812
136activation of Rac GTPase activity (GO:0032863)2.52617778
137protein localization to microtubule (GO:0035372)2.49533701
138cortical actin cytoskeleton organization (GO:0030866)2.47771764
139negative regulation of anoikis (GO:2000811)2.43877519
140stress fiber assembly (GO:0043149)2.43568947
141embryonic eye morphogenesis (GO:0048048)2.42537493
142positive regulation of blood vessel endothelial cell migration (GO:0043536)2.41431672
143protein export from nucleus (GO:0006611)2.40293390
144histone H3-K36 demethylation (GO:0070544)2.40190599
145response to laminar fluid shear stress (GO:0034616)2.39416732
146glucocorticoid receptor signaling pathway (GO:0042921)2.37312363
147hemidesmosome assembly (GO:0031581)2.37242562
148cell adhesion mediated by integrin (GO:0033627)2.36817194
149mammary gland epithelial cell proliferation (GO:0033598)2.35802739
150response to epidermal growth factor (GO:0070849)2.34609578
151chondrocyte development (GO:0002063)2.33017043
152iron ion import (GO:0097286)2.31049964
153mRNA transcription (GO:0009299)2.24652711
154negative regulation of DNA repair (GO:0045738)2.24073182
155dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.23205348
156positive regulation of myotube differentiation (GO:0010831)2.22759444
157germinal center formation (GO:0002467)2.22303316
158trophectodermal cell differentiation (GO:0001829)2.18118461
159planar cell polarity pathway involved in neural tube closure (GO:0090179)2.17566735
160phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.17364349
161mitotic sister chromatid cohesion (GO:0007064)2.17277238
162COPI coating of Golgi vesicle (GO:0048205)2.16777354
163Golgi transport vesicle coating (GO:0048200)2.16777354
164cellular protein complex localization (GO:0034629)2.16557907
165mRNA stabilization (GO:0048255)2.15772280
166RNA stabilization (GO:0043489)2.15772280
167negative regulation of dendrite morphogenesis (GO:0050774)2.15615676
168positive regulation of keratinocyte differentiation (GO:0045618)2.15371400
169SMAD protein complex assembly (GO:0007183)2.14739787
170regulation of anoikis (GO:2000209)2.13697971
171striated muscle atrophy (GO:0014891)2.13559716
172positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.12056176
173histone lysine demethylation (GO:0070076)2.11428170
174semaphorin-plexin signaling pathway (GO:0071526)2.11242194
175negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.11225589
176surfactant homeostasis (GO:0043129)2.09844645
177positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.08863613
178eye morphogenesis (GO:0048592)2.08663040
179cortical cytoskeleton organization (GO:0030865)2.08564961
180peptidyl-serine phosphorylation (GO:0018105)2.07491995
181histone H3-K9 demethylation (GO:0033169)2.07428365
182corticosteroid receptor signaling pathway (GO:0031958)2.07045131
183regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.06315486
184negative regulation of myotube differentiation (GO:0010832)2.05662914
185NLS-bearing protein import into nucleus (GO:0006607)2.04714401
186epithelial cell-cell adhesion (GO:0090136)2.04584828
187regulation of mammary gland epithelial cell proliferation (GO:0033599)2.04111365
188histone demethylation (GO:0016577)2.03119700
189regulation of water loss via skin (GO:0033561)2.01275147
190response to muramyl dipeptide (GO:0032495)2.01240534
191dosage compensation (GO:0007549)2.00681502
192regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1.99132406
193positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling1.99132406
194regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.99094092
195positive regulation of DNA-templated transcription, initiation (GO:2000144)1.98414620
196hippo signaling (GO:0035329)1.97911042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.07267967
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.59639377
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.94615251
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.63372002
5GBX2_23144817_ChIP-Seq_PC3_Human3.10582011
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95014214
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88132826
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82832010
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59914825
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59914825
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.53701237
12MYC_22102868_ChIP-Seq_BL_Human2.50429334
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45117027
14DROSHA_22980978_ChIP-Seq_HELA_Human2.43850015
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40844598
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.37595197
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.35547089
18* TCF7_22412390_ChIP-Seq_EML_Mouse2.34604078
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33694796
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30637959
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28192858
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28073214
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27839360
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27701702
25REST_21632747_ChIP-Seq_MESCs_Mouse2.25910139
26AR_21572438_ChIP-Seq_LNCaP_Human2.17238353
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.14216923
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13651085
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09967267
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.07092578
31CLOCK_20551151_ChIP-Seq_293T_Human2.03260192
32SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01094508
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.96908629
34KDM2B_26808549_Chip-Seq_DND41_Human1.94706257
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.94233232
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86843822
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.84589031
38VDR_21846776_ChIP-Seq_THP-1_Human1.84524733
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83984838
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83279656
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.79926229
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79801750
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.74935702
44* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72311331
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.72306731
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71897093
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70821595
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69243837
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68900292
50SMAD4_21799915_ChIP-Seq_A2780_Human1.67748196
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.64526939
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.63268312
53RACK7_27058665_Chip-Seq_MCF-7_Human1.62542658
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60637765
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59862315
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.59297206
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58632576
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.56785826
59TAF15_26573619_Chip-Seq_HEK293_Human1.56706285
60* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55796241
61* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55796241
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54322268
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53812612
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53263916
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53035652
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51388621
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51216622
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51135789
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49612841
70TP53_16413492_ChIP-PET_HCT116_Human1.46662257
71VDR_24763502_ChIP-Seq_THP-1_Human1.46548772
72RUNX1_27514584_Chip-Seq_MCF-7_Human1.46533202
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46159290
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43994020
75UBF1/2_26484160_Chip-Seq_HMECs_Human1.41610133
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41543326
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41160079
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41039446
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39246349
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38857408
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37522006
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37335061
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.36944461
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.35648015
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33214315
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33104540
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32370344
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31584496
89P300_19829295_ChIP-Seq_ESCs_Human1.31573041
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31270436
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31080698
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30902424
93STAT3_23295773_ChIP-Seq_U87_Human1.30536172
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.30170607
95GATA1_22025678_ChIP-Seq_K562_Human1.29560998
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.29255283
97ZNF274_21170338_ChIP-Seq_K562_Hela1.28833272
98AR_19668381_ChIP-Seq_PC3_Human1.26752814
99* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24821852
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.24410012
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24391456
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24188797
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24137431
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23532270
105AR_25329375_ChIP-Seq_VCAP_Human1.23198463
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.22629183
107AHR_22903824_ChIP-Seq_MCF-7_Human1.22562788
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21404480
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21227493
110* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20981990
111KDM2B_26808549_Chip-Seq_K562_Human1.20172470
112E2F7_22180533_ChIP-Seq_HELA_Human1.20027828
113TBX20_22328084_ChIP-Seq_HEART_Mouse1.19906796
114TBX20_22080862_ChIP-Seq_HEART_Mouse1.19906796
115AR_21909140_ChIP-Seq_LNCAP_Human1.19156959
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18919762
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17466070
118ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17169070
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16614833
120PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16416652
121POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16392944
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16114115
123* RING1B_27294783_Chip-Seq_NPCs_Mouse1.15805867
124* ERG_21242973_ChIP-ChIP_JURKAT_Human1.14725939
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14600244
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14079367
127RXR_22108803_ChIP-Seq_LS180_Human1.13812983
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12937916
129FOXO3_23340844_ChIP-Seq_DLD1_Human1.12885810
130YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12684634
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12532975
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11931162
133TCF4_23295773_ChIP-Seq_U87_Human1.11439728
134LXR_22292898_ChIP-Seq_THP-1_Human1.10176461
135SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10131966
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09669255
137P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09221008
138TRIM28_21343339_ChIP-Seq_HEK293_Human1.09128995
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08388887
140FUS_26573619_Chip-Seq_HEK293_Human1.06899754
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06300784
142CHD1_26751641_Chip-Seq_LNCaP_Human1.06226575
143FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06104494
144CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05874065
145* ATF3_27146783_Chip-Seq_COLON_Human1.05166460
146NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05011407
147SMAD3_21741376_ChIP-Seq_HESCs_Human1.03626980
148VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03245658
149NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02812684
150HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02406323
151MAF_26560356_Chip-Seq_TH1_Human1.02246945
152CREB1_26743006_Chip-Seq_LNCaP_Human1.01061691
153TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00852586
154CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00810709
155PRDM14_20953172_ChIP-Seq_ESCs_Human1.00757805
156BCAT_22108803_ChIP-Seq_LS180_Human1.00499083
157SCL_19346495_ChIP-Seq_HPC-7_Human1.00160174
158RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99174400
159* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98751949
160TP53_18474530_ChIP-ChIP_U2OS_Human0.98720084
161SMAD3_21741376_ChIP-Seq_ESCs_Human0.97948140
162RUNX2_22187159_ChIP-Seq_PCA_Human0.96927253
163* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96382020
164ESR1_20079471_ChIP-ChIP_T-47D_Human0.96269119
165* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95491260
166BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95444375
167DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95199257
168GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94930785
169GATA2_21666600_ChIP-Seq_HMVEC_Human0.94703262
170BRD4_25478319_ChIP-Seq_HGPS_Human0.94643944
171SMAD4_21741376_ChIP-Seq_HESCs_Human0.94440843
172BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94392389
173NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94015053
174DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93587860
175GATA1_19941826_ChIP-Seq_K562_Human0.92873849
176CBX2_27304074_Chip-Seq_ESCs_Mouse0.91903886
177TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91829513
178* PU_27001747_Chip-Seq_BMDM_Mouse0.91019408
179MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90642369
180ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90486042
181TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90380467
182ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89057368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.67925462
2MP0003705_abnormal_hypodermis_morpholog5.38308130
3MP0003880_abnormal_central_pattern4.28967480
4MP0003635_abnormal_synaptic_transmissio4.19674867
5MP0004270_analgesia3.84411651
6MP0009745_abnormal_behavioral_response3.34026265
7MP0010352_gastrointestinal_tract_polyps3.33320815
8MP0002063_abnormal_learning/memory/cond3.27110688
9MP0009046_muscle_twitch3.20249161
10MP0002064_seizures3.13232960
11MP0002009_preneoplasia3.02396257
12MP0005076_abnormal_cell_differentiation2.93764394
13MP0002877_abnormal_melanocyte_morpholog2.91541690
14MP0001968_abnormal_touch/_nociception2.63700917
15MP0002572_abnormal_emotion/affect_behav2.62578188
16MP0001486_abnormal_startle_reflex2.61668498
17MP0002272_abnormal_nervous_system2.52322241
18MP0003091_abnormal_cell_migration2.48534158
19MP0002734_abnormal_mechanical_nocicepti2.47229791
20MP0003566_abnormal_cell_adhesion2.47142196
21MP0008057_abnormal_DNA_replication2.46742238
22MP0002822_catalepsy2.45582236
23MP0009780_abnormal_chondrocyte_physiolo2.44906334
24MP0005423_abnormal_somatic_nervous2.41784418
25MP0001501_abnormal_sleep_pattern2.25594285
26MP0008438_abnormal_cutaneous_collagen2.21961735
27MP0008569_lethality_at_weaning2.20766755
28MP0010234_abnormal_vibrissa_follicle2.03306628
29MP0001440_abnormal_grooming_behavior1.97852579
30MP0003453_abnormal_keratinocyte_physiol1.97827484
31MP0002067_abnormal_sensory_capabilities1.93542974
32MP0000733_abnormal_muscle_development1.83417036
33MP0002736_abnormal_nociception_after1.78026496
34MP0004185_abnormal_adipocyte_glucose1.75127186
35MP0004924_abnormal_behavior1.74021840
36MP0005386_behavior/neurological_phenoty1.74021840
37MP0005275_abnormal_skin_tensile1.73980306
38MP0002184_abnormal_innervation1.73254249
39MP0002796_impaired_skin_barrier1.72968912
40MP0004811_abnormal_neuron_physiology1.72034677
41MP0002909_abnormal_adrenal_gland1.71194147
42MP0004808_abnormal_hematopoietic_stem1.69046685
43MP0004885_abnormal_endolymph1.68890649
44MP0001970_abnormal_pain_threshold1.68373123
45MP0003329_amyloid_beta_deposits1.66581455
46MP0002733_abnormal_thermal_nociception1.64037903
47MP0002735_abnormal_chemical_nociception1.63655947
48MP0004264_abnormal_extraembryonic_tissu1.62174087
49MP0002557_abnormal_social/conspecific_i1.61868009
50MP0005551_abnormal_eye_electrophysiolog1.61486678
51MP0000778_abnormal_nervous_system1.61064634
52MP0003787_abnormal_imprinting1.58135180
53MP0001984_abnormal_olfaction1.51273882
54MP0004858_abnormal_nervous_system1.51217732
55MP0002166_altered_tumor_susceptibility1.50311057
56MP0001348_abnormal_lacrimal_gland1.48342786
57MP0003828_pulmonary_edema1.46593804
58MP0002060_abnormal_skin_morphology1.44825910
59MP0002882_abnormal_neuron_morphology1.43954569
60MP0000955_abnormal_spinal_cord1.43666031
61MP0003633_abnormal_nervous_system1.40925623
62MP0000569_abnormal_digit_pigmentation1.39725460
63MP0003879_abnormal_hair_cell1.35590385
64MP0001958_emphysema1.34400530
65MP0002066_abnormal_motor_capabilities/c1.33917445
66MP0001849_ear_inflammation1.33238776
67MP0005623_abnormal_meninges_morphology1.31147743
68MP0000537_abnormal_urethra_morphology1.30666421
69MP0003191_abnormal_cellular_cholesterol1.28631109
70MP0004947_skin_inflammation1.26433267
71MP0002896_abnormal_bone_mineralization1.25943749
72MP0000627_abnormal_mammary_gland1.25600906
73MP0000579_abnormal_nail_morphology1.25113751
74MP0002006_tumorigenesis1.24651902
75MP0001502_abnormal_circadian_rhythm1.22639826
76MP0005187_abnormal_penis_morphology1.20857437
77MP0005646_abnormal_pituitary_gland1.20212851
78MP0005023_abnormal_wound_healing1.18453233
79MP0002396_abnormal_hematopoietic_system1.17791162
80MP0003631_nervous_system_phenotype1.16495296
81MP0000013_abnormal_adipose_tissue1.15893980
82MP0002090_abnormal_vision1.13180561
83MP0001346_abnormal_lacrimal_gland1.12357292
84MP0001177_atelectasis1.11424655
85MP0000750_abnormal_muscle_regeneration1.11247023
86MP0010630_abnormal_cardiac_muscle1.10731793
87MP0005451_abnormal_body_composition1.10617841
88MP0002152_abnormal_brain_morphology1.09986197
89MP0005621_abnormal_cell_physiology1.09177161
90MP0000767_abnormal_smooth_muscle1.07475058
91MP0004742_abnormal_vestibular_system1.06524302
92MP0001851_eye_inflammation1.06232835
93MP0001915_intracranial_hemorrhage1.05875677
94MP0001216_abnormal_epidermal_layer1.05623533
95MP0002998_abnormal_bone_remodeling1.05325045
96MP0001299_abnormal_eye_distance/1.04316788
97MP0003690_abnormal_glial_cell1.03079565
98MP0002086_abnormal_extraembryonic_tissu1.03018992
99MP0004145_abnormal_muscle_electrophysio1.02700056
100MP0000759_abnormal_skeletal_muscle1.02445438
101MP0000428_abnormal_craniofacial_morphol1.02211372
102MP0005248_abnormal_Harderian_gland1.02200190
103MP0004087_abnormal_muscle_fiber1.02069274
104MP0000377_abnormal_hair_follicle1.01743765
105MP0009053_abnormal_anal_canal1.01572899
106MP0002229_neurodegeneration1.01460466
107MP0000920_abnormal_myelination0.99145570
108MP0004381_abnormal_hair_follicle0.98215189
109MP0000751_myopathy0.97648252
110MP0003634_abnormal_glial_cell0.96362724
111MP0003763_abnormal_thymus_physiology0.95559526
112MP0003941_abnormal_skin_development0.95320186
113MP0000350_abnormal_cell_proliferation0.95166163
114MP0010307_abnormal_tumor_latency0.94252300
115MP0008961_abnormal_basal_metabolism0.92862944
116MP0005501_abnormal_skin_physiology0.92738345
117MP0003279_aneurysm0.92517010
118MP0005666_abnormal_adipose_tissue0.91597374
119MP0003984_embryonic_growth_retardation0.90040542
120MP0002098_abnormal_vibrissa_morphology0.89710376
121MP0003632_abnormal_nervous_system0.88633292
122MP0000383_abnormal_hair_follicle0.87880113
123MP0002088_abnormal_embryonic_growth/wei0.87808811
124MP0002108_abnormal_muscle_morphology0.87143624
125MP0004272_abnormal_basement_membrane0.86757555
126MP0006072_abnormal_retinal_apoptosis0.86665442
127MP0000534_abnormal_ureter_morphology0.86634653
128MP0008874_decreased_physiological_sensi0.86270650
129MP0004510_myositis0.84013123
130MP0005375_adipose_tissue_phenotype0.82879582
131MP0004484_altered_response_of0.82463863
132MP0002925_abnormal_cardiovascular_devel0.82398617
133MP0003075_altered_response_to0.80887418
134MP0003115_abnormal_respiratory_system0.80516387
135MP0000003_abnormal_adipose_tissue0.80238138
136MP0001188_hyperpigmentation0.79736590
137MP0004130_abnormal_muscle_cell0.79709868
138MP0001485_abnormal_pinna_reflex0.79589686
139MP0004085_abnormal_heartbeat0.79175653
140MP0005645_abnormal_hypothalamus_physiol0.78712993
141MP0004215_abnormal_myocardial_fiber0.78348421
142MP0003045_fibrosis0.78288291
143MP0000631_abnormal_neuroendocrine_gland0.77777128
144MP0002089_abnormal_postnatal_growth/wei0.77246729
145MP0008872_abnormal_physiological_respon0.77013485
146MP0001963_abnormal_hearing_physiology0.76993789
147MP0001672_abnormal_embryogenesis/_devel0.76673456
148MP0005380_embryogenesis_phenotype0.76673456
149MP0004233_abnormal_muscle_weight0.76301301
150MP0009672_abnormal_birth_weight0.76270749
151MP0004142_abnormal_muscle_tone0.76221449
152MP0001727_abnormal_embryo_implantation0.76068373
153MP0000762_abnormal_tongue_morphology0.75943158
154MP0000432_abnormal_head_morphology0.75055855
155MP0002752_abnormal_somatic_nervous0.74498038
156MP0002069_abnormal_eating/drinking_beha0.74142172
157MP0003935_abnormal_craniofacial_develop0.74034481
158MP0003122_maternal_imprinting0.73540424
159MP0005253_abnormal_eye_physiology0.73212891
160MP0005167_abnormal_blood-brain_barrier0.73143021
161MP0003448_altered_tumor_morphology0.72811891
162MP0001873_stomach_inflammation0.72152162
163MP0003950_abnormal_plasma_membrane0.71984846
164MP0001905_abnormal_dopamine_level0.71603218
165MP0000604_amyloidosis0.70893300
166MP0000858_altered_metastatic_potential0.70510154
167MP0001730_embryonic_growth_arrest0.69993674
168MP0003123_paternal_imprinting0.68521847
169MP0009931_abnormal_skin_appearance0.68396828
170MP0002249_abnormal_larynx_morphology0.68249379
171MP0008260_abnormal_autophagy0.67553108
172MP0001943_abnormal_respiration0.67109000
173MP0006276_abnormal_autonomic_nervous0.65813709
174MP0003303_peritoneal_inflammation0.65253908
175MP0005409_darkened_coat_color0.63846874
176MP0005394_taste/olfaction_phenotype0.60523299
177MP0005499_abnormal_olfactory_system0.60523299
178MP0003283_abnormal_digestive_organ0.59751228
179MP0002234_abnormal_pharynx_morphology0.58269497
180MP0003861_abnormal_nervous_system0.57753806
181MP0010678_abnormal_skin_adnexa0.57747092
182MP0010386_abnormal_urinary_bladder0.56995503
183MP0000747_muscle_weakness0.56648354
184MP0005535_abnormal_body_temperature0.56570017
185MP0003300_gastrointestinal_ulcer0.53225947

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.89243831
2Myokymia (HP:0002411)5.54919835
3Focal seizures (HP:0007359)5.18800257
4Visual hallucinations (HP:0002367)4.72834301
5Atonic seizures (HP:0010819)4.18772083
6Epileptic encephalopathy (HP:0200134)4.18422484
7Action tremor (HP:0002345)4.15532249
8Progressive cerebellar ataxia (HP:0002073)4.10013361
9Febrile seizures (HP:0002373)3.95856782
10Absence seizures (HP:0002121)3.95352127
11Papilledema (HP:0001085)3.64854369
12Broad-based gait (HP:0002136)3.52360199
13Dialeptic seizures (HP:0011146)3.50033462
14Gaze-evoked nystagmus (HP:0000640)3.41758337
15Truncal ataxia (HP:0002078)3.33696674
16Dysdiadochokinesis (HP:0002075)3.31834683
17Generalized tonic-clonic seizures (HP:0002069)3.28413507
18Hyperacusis (HP:0010780)3.15469408
19Poor eye contact (HP:0000817)3.04240739
20Impaired vibration sensation in the lower limbs (HP:0002166)3.00625963
21Depression (HP:0000716)2.98725444
22Dysmetria (HP:0001310)2.93321477
23Abnormal social behavior (HP:0012433)2.87684943
24Impaired social interactions (HP:0000735)2.87684943
25Urinary bladder sphincter dysfunction (HP:0002839)2.86561118
26Impaired smooth pursuit (HP:0007772)2.83881925
27Spinal cord lesions (HP:0100561)2.83511650
28Syringomyelia (HP:0003396)2.83511650
29Dysmetric saccades (HP:0000641)2.82610554
30Genetic anticipation (HP:0003743)2.82549743
31Supranuclear gaze palsy (HP:0000605)2.80497532
32Intention tremor (HP:0002080)2.77799809
33Hyperventilation (HP:0002883)2.77097140
34Insidious onset (HP:0003587)2.72880706
35Termporal pattern (HP:0011008)2.72880706
36Scanning speech (HP:0002168)2.72337528
37Asymmetry of the thorax (HP:0001555)2.71889343
38Ankle clonus (HP:0011448)2.70134699
39Relative macrocephaly (HP:0004482)2.64961449
40Ankyloglossia (HP:0010296)2.58603243
41Urinary urgency (HP:0000012)2.55259925
42Excessive salivation (HP:0003781)2.53958818
43Drooling (HP:0002307)2.53958818
44Megalencephaly (HP:0001355)2.53622997
45Postural instability (HP:0002172)2.52479500
46Heterotopia (HP:0002282)2.51421073
47Amblyopia (HP:0000646)2.51242998
48Hemiplegia (HP:0002301)2.50053893
49Macroorchidism (HP:0000053)2.48813665
50Anxiety (HP:0000739)2.48583925
51Abnormality of ocular smooth pursuit (HP:0000617)2.48348499
52Curly hair (HP:0002212)2.47759057
53Deep palmar crease (HP:0006191)2.42961107
54Deep philtrum (HP:0002002)2.42303008
55Stereotypic behavior (HP:0000733)2.42267101
56Fetal akinesia sequence (HP:0001989)2.38535981
57Diplopia (HP:0000651)2.36884767
58Abnormality of binocular vision (HP:0011514)2.36884767
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.31504793
60Osteolytic defects of the hand bones (HP:0009699)2.31378955
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.31378955
62Cerebral inclusion bodies (HP:0100314)2.28318962
63Protrusio acetabuli (HP:0003179)2.28031109
64Inappropriate behavior (HP:0000719)2.27876245
65Overgrowth (HP:0001548)2.26683679
66Pointed chin (HP:0000307)2.22558984
67Mutism (HP:0002300)2.22222935
68Aqueductal stenosis (HP:0002410)2.20988710
69Arterial tortuosity (HP:0005116)2.20172896
70Abnormal eating behavior (HP:0100738)2.20073539
71Cerebral aneurysm (HP:0004944)2.19926707
72Ventricular fibrillation (HP:0001663)2.19810559
73Cystic hygroma (HP:0000476)2.19020770
74Spastic gait (HP:0002064)2.18579243
75Hemiparesis (HP:0001269)2.16995389
76Progressive inability to walk (HP:0002505)2.16890967
77Abnormality of the fingertips (HP:0001211)2.16870648
78Mitral valve prolapse (HP:0001634)2.16386131
79Abnormality of the lower motor neuron (HP:0002366)2.15428762
80Cubitus valgus (HP:0002967)2.15076129
81Absent speech (HP:0001344)2.13941765
82Subacute progressive viral hepatitis (HP:0006572)2.12785097
83Resting tremor (HP:0002322)2.12108064
84Central scotoma (HP:0000603)2.12028459
85Annular pancreas (HP:0001734)2.10578764
86Sparse lateral eyebrow (HP:0005338)2.05778832
87Lower limb amyotrophy (HP:0007210)2.04941432
88Abnormality of oral frenula (HP:0000190)2.03438598
89Aortic aneurysm (HP:0004942)2.03310577
90Broad face (HP:0000283)2.03127952
91Vertebral arch anomaly (HP:0008438)2.02403045
92Absent frontal sinuses (HP:0002688)1.99834863
93Bradykinesia (HP:0002067)1.98971421
94Hyporeflexia of lower limbs (HP:0002600)1.98883298
95Impaired vibratory sensation (HP:0002495)1.98737124
96Neurofibrillary tangles (HP:0002185)1.97128544
97Abnormality of the corticospinal tract (HP:0002492)1.97033626
98Long palpebral fissure (HP:0000637)1.96159371
99Blue irides (HP:0000635)1.94904373
100Lower limb asymmetry (HP:0100559)1.93651385
101Dislocated radial head (HP:0003083)1.93295835
102Flat acetabular roof (HP:0003180)1.91328064
103Premature rupture of membranes (HP:0001788)1.91178643
104Vascular tortuosity (HP:0004948)1.89493684
105Shallow orbits (HP:0000586)1.88738154
106Epileptiform EEG discharges (HP:0011182)1.87899636
107Mitral regurgitation (HP:0001653)1.87604970
108Abnormality of macular pigmentation (HP:0008002)1.87399967
109Overriding aorta (HP:0002623)1.86631317
110Elfin facies (HP:0004428)1.86516751
111Dilatation of the ascending aorta (HP:0005111)1.85987493
112Renovascular hypertension (HP:0100817)1.85739136
113Lower limb muscle weakness (HP:0007340)1.85407866
114Gait ataxia (HP:0002066)1.84533046
115Insomnia (HP:0100785)1.82670564
116Bladder diverticulum (HP:0000015)1.82553573
117Flat cornea (HP:0007720)1.82125013
118Aneurysm (HP:0002617)1.81342838
119Acute myeloid leukemia (HP:0004808)1.80492257
120Narrow palate (HP:0000189)1.80489206
121Widely spaced teeth (HP:0000687)1.79406545
122Renal duplication (HP:0000075)1.79152186
123Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78563847
124EEG with generalized epileptiform discharges (HP:0011198)1.78054876
125Obstructive sleep apnea (HP:0002870)1.77911965
126Persistence of primary teeth (HP:0006335)1.76810734
127Agitation (HP:0000713)1.76042208
128Abnormality of the radial head (HP:0003995)1.75032075
129Generalized myoclonic seizures (HP:0002123)1.74694666
130Distal lower limb amyotrophy (HP:0008944)1.74691335
131Patellar dislocation (HP:0002999)1.74532232
132Aortic dissection (HP:0002647)1.73853242
133Intellectual disability, profound (HP:0002187)1.73778474
134Thickened helices (HP:0000391)1.73363428
135Status epilepticus (HP:0002133)1.73165685
136Torticollis (HP:0000473)1.73112243
137Ulnar bowing (HP:0003031)1.72325554
138Abnormality of salivation (HP:0100755)1.72165550
139Spondylolisthesis (HP:0003302)1.71787945
140Subaortic stenosis (HP:0001682)1.71248946
141Abnormality of the left ventricular outflow tract (HP:0011103)1.71248946
142Advanced eruption of teeth (HP:0006288)1.71100284
143Rapidly progressive (HP:0003678)1.70814106
144Coarse hair (HP:0002208)1.70805481
145Uterine leiomyosarcoma (HP:0002891)1.70227218
146Leiomyosarcoma (HP:0100243)1.70227218
147Aplasia involving bones of the upper limbs (HP:0009823)1.69966664
148Aplasia of the phalanges of the hand (HP:0009802)1.69966664
149Aplasia involving bones of the extremities (HP:0009825)1.69966664
150Germ cell neoplasia (HP:0100728)1.69694404
151Congenital stationary night blindness (HP:0007642)1.69372706
152Decreased motor nerve conduction velocity (HP:0003431)1.67526432
153Hyperthyroidism (HP:0000836)1.66978886
154Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66267502
155Arnold-Chiari malformation (HP:0002308)1.65499406
156Akinesia (HP:0002304)1.65450387
157Segmental peripheral demyelination/remyelination (HP:0003481)1.65003921
158Abnormality of saccadic eye movements (HP:0000570)1.64743509
159Hypsarrhythmia (HP:0002521)1.64702246
160Pheochromocytoma (HP:0002666)1.64219531
161Postural tremor (HP:0002174)1.63935511
162Transitional cell carcinoma of the bladder (HP:0006740)1.63620063
163Long eyelashes (HP:0000527)1.63426834
164Neonatal hypoglycemia (HP:0001998)1.63257746
165Right ventricular cardiomyopathy (HP:0011663)1.62485064
166Neuronal loss in central nervous system (HP:0002529)1.61893833
167Incomplete penetrance (HP:0003829)1.60588266
168Thin bony cortex (HP:0002753)1.60087185
169Atrophic scars (HP:0001075)1.59843872
170Thin ribs (HP:0000883)1.59326694
171Abnormality of the phalanges of the hallux (HP:0010057)1.56582647
172Disproportionate tall stature (HP:0001519)1.56146677
173Abnormality of nail color (HP:0100643)1.56119268
174Popliteal pterygium (HP:0009756)1.55892539
175Bladder carcinoma (HP:0002862)1.55587146
176Bladder neoplasm (HP:0009725)1.55587146
177Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.55389460
178Fragile skin (HP:0001030)1.54749882
179Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.53208944
180Lip pit (HP:0100267)1.52917108
181Hyperextensible skin (HP:0000974)1.51256097
182Distal lower limb muscle weakness (HP:0009053)1.50281436
183Wormian bones (HP:0002645)1.49663549
184Dental malocclusion (HP:0000689)1.48489880
185Abnormality of the parietal bone (HP:0002696)1.47709096
186Exostoses (HP:0100777)1.47609930
187Onion bulb formation (HP:0003383)1.47490352
188Hammertoe (HP:0001765)1.47409655

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.18817030
2NTRK34.10215573
3CDK123.73913829
4MAP3K93.67825659
5AKT33.17352302
6MAP3K42.91094848
7EEF2K2.63127065
8DAPK22.47840014
9MINK12.46837198
10PAK62.32085843
11ICK2.29929318
12KSR22.28850738
13RIPK42.27355688
14SMG12.26794664
15MARK12.14626386
16CAMKK12.14189708
17MAP2K71.98444437
18PRKD31.95648739
19NTRK21.92556992
20BRD41.86835803
21IRAK31.83841986
22SIK11.81838170
23MAP3K21.80203753
24MAP2K41.73430741
25NTRK11.72823801
26KSR11.64176458
27PNCK1.62130401
28TTN1.56436478
29CDK51.55582949
30MAP3K101.51567874
31CAMKK21.50250296
32PLK21.48424821
33PKN21.46262320
34MAP3K121.44574214
35CAMK1D1.40441191
36FGFR41.39764805
37TYRO31.39622357
38MTOR1.37085887
39SIK21.36220876
40MAP3K131.30599012
41LATS11.28643582
42STK381.27712567
43DAPK11.27558053
44FES1.25033924
45MELK1.20447757
46CDK191.17261889
47MAP3K141.17159702
48GRK51.16484650
49STK111.15152926
50TAF11.14980219
51RET1.12555970
52BRAF1.12386137
53PRKCH1.10768962
54SCYL21.10107173
55CDK61.09727646
56PRPF4B1.09552751
57FGFR21.08369558
58RIPK11.06149115
59EPHA21.05845211
60ALK1.04443369
61UHMK11.00894960
62PRKCG0.98854781
63CDK90.98338575
64CASK0.98020150
65PTK20.97677246
66CAMK1G0.95328082
67SGK2230.94583997
68SGK4940.94583997
69RPS6KB20.94172616
70PDK10.90640486
71SGK30.90508833
72CAMK2A0.90290638
73RAF10.90186641
74CDK140.89471058
75WNK10.88145981
76CDK150.87823555
77SGK20.86942626
78SGK10.86725969
79OXSR10.86555994
80CDK180.86502855
81TAOK10.86119886
82FRK0.86043036
83NEK90.85585072
84TNIK0.83929768
85CAMK10.81673141
86MAP2K30.79672415
87DMPK0.79020875
88MAP3K70.78432422
89PAK30.78420799
90PDPK10.77543233
91NEK60.77542346
92CAMK2B0.77365777
93TRPM70.76912291
94IRAK40.76115611
95PTK2B0.75348477
96PAK20.74113841
97CDK11A0.73921928
98HIPK20.72755572
99RPS6KA20.72523389
100JAK10.71889540
101ARAF0.71204226
102IRAK20.70702941
103LMTK20.69629346
104CSNK1G20.67068345
105TAOK20.66385822
106FER0.64741455
107MAPK130.63286538
108DYRK1A0.63177401
109MAPK120.61685193
110MAP3K10.60234269
111FGR0.59588442
112BMPR20.58320253
113CHUK0.57867349
114ROCK20.56958606
115FYN0.56784040
116STK390.55898578
117MARK20.55891375
118RPS6KA30.55779421
119CDC42BPA0.54851563
120MAPK100.54452796
121NLK0.53944537
122DDR20.53487124
123MAPK70.53395458
124EPHB10.53110526
125ERN10.52489283
126STK240.52417661
127MAPK110.51566693
128PTK60.51398709
129CAMK2D0.50411772
130RPS6KL10.49527378
131RPS6KC10.49527378
132MST1R0.48529739
133MAP2K10.48041301
134ZAP700.47080198
135PHKG10.46633720
136PHKG20.46633720
137RPS6KB10.46371204
138TRIB30.45891578
139YES10.44328639
140PRKCE0.44039828
141MAP2K20.43285624
142PAK40.41251662
143TNK20.40702912
144PRKCZ0.40300654
145PDGFRB0.39193977
146FGFR30.38333027
147MOS0.37148816
148PDGFRA0.36899299
149CDK40.36421636
150CAMK40.36377296
151JAK20.36069506
152FGFR10.35703989
153PRKCB0.35420627
154LATS20.35096658
155CDK70.32797417
156PRKD20.32573583

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.01740720
2Synaptic vesicle cycle_Homo sapiens_hsa047212.59691671
3Long-term potentiation_Homo sapiens_hsa047202.57779589
4Olfactory transduction_Homo sapiens_hsa047402.53329983
5Circadian entrainment_Homo sapiens_hsa047132.43162029
6GABAergic synapse_Homo sapiens_hsa047272.37265749
7Glutamatergic synapse_Homo sapiens_hsa047242.36389336
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35382477
9Morphine addiction_Homo sapiens_hsa050322.22062833
10Amphetamine addiction_Homo sapiens_hsa050312.17154447
11Chronic myeloid leukemia_Homo sapiens_hsa052202.14430547
12Salivary secretion_Homo sapiens_hsa049702.08079757
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98835890
14Dopaminergic synapse_Homo sapiens_hsa047281.98772940
15Thyroid cancer_Homo sapiens_hsa052161.92271028
16Gastric acid secretion_Homo sapiens_hsa049711.89604244
17Cholinergic synapse_Homo sapiens_hsa047251.79974521
18Phototransduction_Homo sapiens_hsa047441.75842462
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74285721
20Acute myeloid leukemia_Homo sapiens_hsa052211.73623629
21Pancreatic cancer_Homo sapiens_hsa052121.73470515
22Insulin secretion_Homo sapiens_hsa049111.73169410
23Long-term depression_Homo sapiens_hsa047301.69887905
24Renin secretion_Homo sapiens_hsa049241.69334386
25Oxytocin signaling pathway_Homo sapiens_hsa049211.64195349
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61360667
27GnRH signaling pathway_Homo sapiens_hsa049121.59257970
28Bladder cancer_Homo sapiens_hsa052191.56834432
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53348204
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49219951
31Prostate cancer_Homo sapiens_hsa052151.46721788
32B cell receptor signaling pathway_Homo sapiens_hsa046621.43767135
33Serotonergic synapse_Homo sapiens_hsa047261.41763513
34Taste transduction_Homo sapiens_hsa047421.40475836
35Cocaine addiction_Homo sapiens_hsa050301.37165375
36MicroRNAs in cancer_Homo sapiens_hsa052061.36574394
37Calcium signaling pathway_Homo sapiens_hsa040201.34603547
38Adherens junction_Homo sapiens_hsa045201.30660690
39Glioma_Homo sapiens_hsa052141.29599768
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29176692
41Gap junction_Homo sapiens_hsa045401.27803434
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26934188
43Estrogen signaling pathway_Homo sapiens_hsa049151.26222591
44cAMP signaling pathway_Homo sapiens_hsa040241.24599546
45Type II diabetes mellitus_Homo sapiens_hsa049301.23971857
46Small cell lung cancer_Homo sapiens_hsa052221.23777280
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21035610
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20851987
49Nitrogen metabolism_Homo sapiens_hsa009101.16803968
50Notch signaling pathway_Homo sapiens_hsa043301.16674297
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16663801
52Dorso-ventral axis formation_Homo sapiens_hsa043201.16124968
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.12322052
54ErbB signaling pathway_Homo sapiens_hsa040121.11257422
55Hepatitis B_Homo sapiens_hsa051611.10875592
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09728061
57FoxO signaling pathway_Homo sapiens_hsa040681.07790593
58Amoebiasis_Homo sapiens_hsa051461.07401263
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06483779
60Melanogenesis_Homo sapiens_hsa049161.06444332
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03551648
62Axon guidance_Homo sapiens_hsa043601.03283543
63Prion diseases_Homo sapiens_hsa050200.99558686
64Hepatitis C_Homo sapiens_hsa051600.98923657
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.97414528
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95539170
67TNF signaling pathway_Homo sapiens_hsa046680.95457550
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95211605
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.94034610
70Collecting duct acid secretion_Homo sapiens_hsa049660.93296960
71Osteoclast differentiation_Homo sapiens_hsa043800.92366546
72Pancreatic secretion_Homo sapiens_hsa049720.92357434
73Thyroid hormone synthesis_Homo sapiens_hsa049180.91922740
74Melanoma_Homo sapiens_hsa052180.91898513
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87736432
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.86636908
77Dilated cardiomyopathy_Homo sapiens_hsa054140.86103709
78Oocyte meiosis_Homo sapiens_hsa041140.85036700
79VEGF signaling pathway_Homo sapiens_hsa043700.84975832
80MAPK signaling pathway_Homo sapiens_hsa040100.83116078
81ECM-receptor interaction_Homo sapiens_hsa045120.82441876
82Choline metabolism in cancer_Homo sapiens_hsa052310.81622241
83Influenza A_Homo sapiens_hsa051640.81212458
84HIF-1 signaling pathway_Homo sapiens_hsa040660.81112022
85mTOR signaling pathway_Homo sapiens_hsa041500.81070672
86Insulin resistance_Homo sapiens_hsa049310.80744145
87Viral carcinogenesis_Homo sapiens_hsa052030.80243124
88Toxoplasmosis_Homo sapiens_hsa051450.80219677
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76851672
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.76464248
91AMPK signaling pathway_Homo sapiens_hsa041520.75723126
92Hippo signaling pathway_Homo sapiens_hsa043900.75170217
93Pathways in cancer_Homo sapiens_hsa052000.73161289
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72821766
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72651446
96Apoptosis_Homo sapiens_hsa042100.71257404
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70657803
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69679699
99Measles_Homo sapiens_hsa051620.69397483
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69058056
101Lysine degradation_Homo sapiens_hsa003100.68214528
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.67965099
103Leishmaniasis_Homo sapiens_hsa051400.67887975
104Renal cell carcinoma_Homo sapiens_hsa052110.67755591
105Rap1 signaling pathway_Homo sapiens_hsa040150.67591142
106Inositol phosphate metabolism_Homo sapiens_hsa005620.67045679
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.66029476
108HTLV-I infection_Homo sapiens_hsa051660.65991533
109Vibrio cholerae infection_Homo sapiens_hsa051100.65796351
110Non-small cell lung cancer_Homo sapiens_hsa052230.65776609
111Ras signaling pathway_Homo sapiens_hsa040140.63856001
112Endometrial cancer_Homo sapiens_hsa052130.63744368
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.62602275
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62368350
115Tuberculosis_Homo sapiens_hsa051520.62356735
116Cardiac muscle contraction_Homo sapiens_hsa042600.60702022
117Endocytosis_Homo sapiens_hsa041440.60537110
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58940961
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.58483683
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57019886
121Chemokine signaling pathway_Homo sapiens_hsa040620.56839865
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56826607
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55336803
124Glucagon signaling pathway_Homo sapiens_hsa049220.54565505
125Wnt signaling pathway_Homo sapiens_hsa043100.53657372
126Type I diabetes mellitus_Homo sapiens_hsa049400.53392499
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53115590
128Platelet activation_Homo sapiens_hsa046110.52283397
129Alcoholism_Homo sapiens_hsa050340.51373838
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51003866
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50925168
132Circadian rhythm_Homo sapiens_hsa047100.50096030
133Ovarian steroidogenesis_Homo sapiens_hsa049130.49171138
134Tight junction_Homo sapiens_hsa045300.46499095
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46285810
136Colorectal cancer_Homo sapiens_hsa052100.45832483
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45772122
138Prolactin signaling pathway_Homo sapiens_hsa049170.44585164
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44098022
140Proteoglycans in cancer_Homo sapiens_hsa052050.43237027
141Insulin signaling pathway_Homo sapiens_hsa049100.43071966
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42492839
143African trypanosomiasis_Homo sapiens_hsa051430.41801503
144T cell receptor signaling pathway_Homo sapiens_hsa046600.41727842
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38971007
146Focal adhesion_Homo sapiens_hsa045100.37402205

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