PURG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.03564196
2neuron cell-cell adhesion (GO:0007158)5.87111980
3presynaptic membrane assembly (GO:0097105)5.09901177
4vocalization behavior (GO:0071625)4.78564507
5presynaptic membrane organization (GO:0097090)4.76033773
6nucleobase catabolic process (GO:0046113)4.75158714
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.65583358
8synaptic vesicle exocytosis (GO:0016079)4.65500937
9behavioral response to nicotine (GO:0035095)4.64529205
10protein localization to synapse (GO:0035418)4.46593589
11neuronal action potential propagation (GO:0019227)4.42418390
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.35807546
13postsynaptic membrane organization (GO:0001941)4.32365320
14neuron recognition (GO:0008038)4.23594382
15axon ensheathment in central nervous system (GO:0032291)4.22713207
16central nervous system myelination (GO:0022010)4.22713207
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.21209314
18glutamate secretion (GO:0014047)4.19793476
19locomotory exploration behavior (GO:0035641)4.17924194
20L-amino acid import (GO:0043092)4.00102847
21axonal fasciculation (GO:0007413)3.94653325
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.93662126
23cerebral cortex radially oriented cell migration (GO:0021799)3.93616968
24gamma-aminobutyric acid transport (GO:0015812)3.90393955
25regulation of synaptic vesicle exocytosis (GO:2000300)3.89485917
26regulation of glutamate receptor signaling pathway (GO:1900449)3.88026616
27retinal ganglion cell axon guidance (GO:0031290)3.79600313
28glutamate receptor signaling pathway (GO:0007215)3.72670206
29negative regulation of neurotransmitter transport (GO:0051589)3.72664746
30synaptic transmission, glutamatergic (GO:0035249)3.66706826
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.59228130
32neuron-neuron synaptic transmission (GO:0007270)3.55836223
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55200695
34synaptic vesicle maturation (GO:0016188)3.54466754
35negative regulation of synaptic transmission, GABAergic (GO:0032229)3.51243803
36exploration behavior (GO:0035640)3.47181913
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46450989
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46297052
39layer formation in cerebral cortex (GO:0021819)3.45713353
40cerebellar granule cell differentiation (GO:0021707)3.43992970
41dendritic spine morphogenesis (GO:0060997)3.43782749
42sequestering of actin monomers (GO:0042989)3.43502593
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.41453890
44cell migration in hindbrain (GO:0021535)3.39351502
45dendrite morphogenesis (GO:0048813)3.35565385
46neurotransmitter secretion (GO:0007269)3.32349126
47transmission of nerve impulse (GO:0019226)3.31340505
48long-chain fatty acid biosynthetic process (GO:0042759)3.30755105
49synapse assembly (GO:0007416)3.29225993
50regulation of neuronal synaptic plasticity (GO:0048168)3.28276819
51regulation of dendritic spine morphogenesis (GO:0061001)3.26025780
52peptidyl-arginine omega-N-methylation (GO:0035247)3.24852444
53negative regulation of neurotransmitter secretion (GO:0046929)3.23924497
54central nervous system projection neuron axonogenesis (GO:0021952)3.22004509
55peptidyl-arginine N-methylation (GO:0035246)3.20039274
56peptidyl-arginine methylation (GO:0018216)3.20039274
57nonmotile primary cilium assembly (GO:0035058)3.18197215
58neurotransmitter-gated ion channel clustering (GO:0072578)3.18030565
59amino acid import (GO:0043090)3.15558989
60regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14238503
61positive regulation of synapse assembly (GO:0051965)3.14095721
62regulation of synaptic vesicle transport (GO:1902803)3.14037201
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.12953549
64adult walking behavior (GO:0007628)3.11775660
65establishment of mitochondrion localization (GO:0051654)3.10677953
66synaptic vesicle docking involved in exocytosis (GO:0016081)3.09367210
67calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.08839462
68nerve growth factor signaling pathway (GO:0038180)3.07937369
69regulation of synapse structural plasticity (GO:0051823)3.04241015
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03913475
71spinal cord development (GO:0021510)3.03523257
72positive regulation of synapse maturation (GO:0090129)3.03418879
73axon extension (GO:0048675)2.99885429
74forebrain neuron differentiation (GO:0021879)2.99139019
75regulation of postsynaptic membrane potential (GO:0060078)2.98221761
76olfactory bulb development (GO:0021772)2.98130000
77intraciliary transport (GO:0042073)2.96589578
78neurotransmitter uptake (GO:0001504)2.95595715
79myelination (GO:0042552)2.94531270
80regulation of dendritic spine development (GO:0060998)2.94042892
81negative regulation of dendrite development (GO:2000171)2.93701262
82synaptic transmission, cholinergic (GO:0007271)2.93091744
83negative regulation of dendrite morphogenesis (GO:0050774)2.92770757
84regulation of synaptic transmission, glutamatergic (GO:0051966)2.91823261
85ensheathment of neurons (GO:0007272)2.91045919
86axon ensheathment (GO:0008366)2.91045919
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89717486
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89119217
89positive regulation of dendritic spine morphogenesis (GO:0061003)2.88309742
90response to auditory stimulus (GO:0010996)2.87868213
91positive regulation of membrane potential (GO:0045838)2.87438378
92regulation of synapse maturation (GO:0090128)2.87369895
93synapse organization (GO:0050808)2.85510733
94central nervous system neuron axonogenesis (GO:0021955)2.84988009
95regulation of neurotransmitter secretion (GO:0046928)2.84106178
96regulation of development, heterochronic (GO:0040034)2.83397416
97regulation of synaptic plasticity (GO:0048167)2.83202754
98neurotransmitter transport (GO:0006836)2.82309136
99mitochondrion transport along microtubule (GO:0047497)2.81916462
100establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.81916462
101mechanosensory behavior (GO:0007638)2.81847490
102negative regulation of axonogenesis (GO:0050771)2.81812822
103dendrite development (GO:0016358)2.80080822
104regulation of synapse assembly (GO:0051963)2.79474190
105substrate-independent telencephalic tangential migration (GO:0021826)2.79248569
106substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.79248569
107synaptic vesicle endocytosis (GO:0048488)2.78110769
108somite development (GO:0061053)2.78067877
109long-term synaptic potentiation (GO:0060291)2.77634169
110apical protein localization (GO:0045176)2.77275157
111negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75936285
112regulation of dendrite morphogenesis (GO:0048814)2.75270370
113neuronal ion channel clustering (GO:0045161)2.75260748
114startle response (GO:0001964)2.75228758
115auditory behavior (GO:0031223)2.74993502
116regulation of collateral sprouting (GO:0048670)2.74085725
117membrane hyperpolarization (GO:0060081)2.73374178
118limb bud formation (GO:0060174)2.73357083
119positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72989299
120hippocampus development (GO:0021766)2.72538717
121negative regulation of axon extension (GO:0030517)2.72308294
122learning (GO:0007612)2.71983470
123cerebellar Purkinje cell differentiation (GO:0021702)2.71959325
124neuron migration (GO:0001764)2.67800756
125regulation of timing of cell differentiation (GO:0048505)2.66408251
126head development (GO:0060322)2.65229951
127behavioral response to ethanol (GO:0048149)2.65218874
128retina layer formation (GO:0010842)2.63396482
129neuromuscular synaptic transmission (GO:0007274)2.58033759
130spinal cord association neuron differentiation (GO:0021527)2.56993536
131negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55073130
132axonogenesis (GO:0007409)2.54177591
133appendage development (GO:0048736)2.52041437
134limb development (GO:0060173)2.52041437
135cerebral cortex neuron differentiation (GO:0021895)2.51831589
136neuronal stem cell maintenance (GO:0097150)2.51613162
137regulation of respiratory system process (GO:0044065)2.49614162
138neurofilament cytoskeleton organization (GO:0060052)2.49157367
139striatum development (GO:0021756)2.48751538
140behavioral defense response (GO:0002209)2.48233629
141behavioral fear response (GO:0001662)2.48233629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.55207981
2GBX2_23144817_ChIP-Seq_PC3_Human3.90002378
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15239323
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07280998
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95145094
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69124929
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69124929
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.58099091
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57431179
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52650453
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47995088
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44595095
13TAF15_26573619_Chip-Seq_HEK293_Human2.34326771
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31876377
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.24236652
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17983295
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.16305592
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15407720
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.11499397
20REST_21632747_ChIP-Seq_MESCs_Mouse2.08745656
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08255937
22* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04907817
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.95911664
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93907480
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93137123
26* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83960846
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83371798
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82853909
29DROSHA_22980978_ChIP-Seq_HELA_Human1.81375206
30* P300_19829295_ChIP-Seq_ESCs_Human1.80092733
31SMAD4_21799915_ChIP-Seq_A2780_Human1.77324790
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.72929717
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72551636
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72527557
35* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72487269
36FUS_26573619_Chip-Seq_HEK293_Human1.71785180
37* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71656895
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70342013
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.68288998
40* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67253144
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65915914
42AR_21572438_ChIP-Seq_LNCaP_Human1.63487028
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62798078
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.62713953
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58443491
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.56262840
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.53831994
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51066347
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44995834
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.41884962
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.41454100
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40546761
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40227192
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.39121345
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37087227
56RNF2_27304074_Chip-Seq_NSC_Mouse1.35591873
57STAT3_23295773_ChIP-Seq_U87_Human1.34460360
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33289360
59ER_23166858_ChIP-Seq_MCF-7_Human1.30590966
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29781266
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29725842
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.27561249
63ZNF274_21170338_ChIP-Seq_K562_Hela1.26980531
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26735597
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26628195
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.26079858
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24799441
68IRF1_19129219_ChIP-ChIP_H3396_Human1.23931923
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.23593565
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22138230
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21424071
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.20847612
73* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20735200
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19290487
75TCF4_23295773_ChIP-Seq_U87_Human1.19220171
76AR_25329375_ChIP-Seq_VCAP_Human1.17429845
77* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16979747
78* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16979747
79AR_19668381_ChIP-Seq_PC3_Human1.16652396
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.16462287
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13611297
82VDR_22108803_ChIP-Seq_LS180_Human1.13298251
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13211650
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.12371650
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.11262317
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11127730
87TP53_16413492_ChIP-PET_HCT116_Human1.10537779
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.10263397
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09751850
90AHR_22903824_ChIP-Seq_MCF-7_Human1.09495349
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09251679
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08551507
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08460417
94* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07802562
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07715024
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06762687
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06181401
98SOX9_26525672_Chip-Seq_HEART_Mouse1.05362389
99EWS_26573619_Chip-Seq_HEK293_Human1.04921299
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04772033
101CBP_20019798_ChIP-Seq_JUKART_Human1.02702005
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02702005
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02678752
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02639201
105RUNX2_22187159_ChIP-Seq_PCA_Human1.02326829
106JUN_21703547_ChIP-Seq_K562_Human1.02046596
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00756307
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.98612853
109BCAT_22108803_ChIP-Seq_LS180_Human0.98039816
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97969022
111IGF1R_20145208_ChIP-Seq_DFB_Human0.97701237
112OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97601853
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97572763
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97536084
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97277629
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97117402
117TAL1_26923725_Chip-Seq_HPCs_Mouse0.96996040
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96648151
119* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96490074
120NANOG_18555785_Chip-Seq_ESCs_Mouse0.95611491
121* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94899392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.61020013
2MP0003880_abnormal_central_pattern4.50418710
3MP0004270_analgesia3.79873732
4MP0003635_abnormal_synaptic_transmissio3.49900639
5MP0009745_abnormal_behavioral_response3.01505918
6MP0002063_abnormal_learning/memory/cond2.91221618
7MP0002064_seizures2.81125466
8MP0000778_abnormal_nervous_system2.73887707
9MP0002272_abnormal_nervous_system2.57196993
10MP0001486_abnormal_startle_reflex2.56800470
11MP0002572_abnormal_emotion/affect_behav2.51082442
12MP0001968_abnormal_touch/_nociception2.47647843
13MP0002734_abnormal_mechanical_nocicepti2.45640621
14MP0009046_muscle_twitch2.41836248
15MP0003787_abnormal_imprinting2.34078050
16MP0005423_abnormal_somatic_nervous2.18632565
17MP0000566_synostosis2.14102940
18MP0002735_abnormal_chemical_nociception2.09469501
19MP0002184_abnormal_innervation2.03776596
20MP0001529_abnormal_vocalization2.02794076
21MP0000920_abnormal_myelination2.00258113
22MP0002736_abnormal_nociception_after1.94764753
23MP0002067_abnormal_sensory_capabilities1.89826139
24MP0002733_abnormal_thermal_nociception1.89043883
25MP0003890_abnormal_embryonic-extraembry1.84636191
26MP0001970_abnormal_pain_threshold1.77057909
27MP0001440_abnormal_grooming_behavior1.71966204
28MP0000955_abnormal_spinal_cord1.71761638
29MP0004885_abnormal_endolymph1.70945805
30MP0002557_abnormal_social/conspecific_i1.67742919
31MP0000049_abnormal_middle_ear1.66713753
32MP0003329_amyloid_beta_deposits1.63385088
33MP0004924_abnormal_behavior1.61822622
34MP0005386_behavior/neurological_phenoty1.61822622
35MP0009780_abnormal_chondrocyte_physiolo1.60952189
36MP0002638_abnormal_pupillary_reflex1.60746033
37MP0002882_abnormal_neuron_morphology1.56648698
38MP0006276_abnormal_autonomic_nervous1.56324085
39MP0006072_abnormal_retinal_apoptosis1.53851423
40MP0003122_maternal_imprinting1.47825902
41MP0004742_abnormal_vestibular_system1.47553663
42MP0000569_abnormal_digit_pigmentation1.47166574
43MP0010030_abnormal_orbit_morphology1.46860313
44MP0005646_abnormal_pituitary_gland1.43538456
45MP0008569_lethality_at_weaning1.43317877
46MP0002102_abnormal_ear_morphology1.42705468
47MP0004811_abnormal_neuron_physiology1.42241286
48MP0001905_abnormal_dopamine_level1.42091002
49MP0002066_abnormal_motor_capabilities/c1.39898883
50MP0001485_abnormal_pinna_reflex1.38138571
51MP0004133_heterotaxia1.36323348
52MP0001501_abnormal_sleep_pattern1.36005098
53MP0008877_abnormal_DNA_methylation1.34386907
54MP0002234_abnormal_pharynx_morphology1.33708807
55MP0001293_anophthalmia1.32282865
56MP0004142_abnormal_muscle_tone1.32185460
57MP0002152_abnormal_brain_morphology1.30919882
58MP0003121_genomic_imprinting1.28483681
59MP0003119_abnormal_digestive_system1.28314299
60MP0004145_abnormal_muscle_electrophysio1.28164645
61MP0000537_abnormal_urethra_morphology1.25635530
62MP0004858_abnormal_nervous_system1.25322039
63MP0002938_white_spotting1.24094383
64MP0005409_darkened_coat_color1.22464852
65MP0003634_abnormal_glial_cell1.22116825
66MP0003631_nervous_system_phenotype1.20787874
67MP0002653_abnormal_ependyma_morphology1.20685089
68MP0003632_abnormal_nervous_system1.19939436
69MP0001984_abnormal_olfaction1.19506598
70MP0003385_abnormal_body_wall1.17019252
71MP0001286_abnormal_eye_development1.16908757
72MP0001188_hyperpigmentation1.16681586
73MP0003633_abnormal_nervous_system1.15686412
74MP0003136_yellow_coat_color1.12598712
75MP0005253_abnormal_eye_physiology1.11413140
76MP0001963_abnormal_hearing_physiology1.11047071
77MP0000631_abnormal_neuroendocrine_gland1.10127748
78MP0005499_abnormal_olfactory_system1.09303574
79MP0005394_taste/olfaction_phenotype1.09303574
80MP0005171_absent_coat_pigmentation1.06528865
81MP0005551_abnormal_eye_electrophysiolog1.05687112
82MP0003938_abnormal_ear_development1.05236231
83MP0001299_abnormal_eye_distance/1.04426603
84MP0003690_abnormal_glial_cell1.04270752
85MP0002752_abnormal_somatic_nervous1.03898762
86MP0001986_abnormal_taste_sensitivity1.03378853
87MP0002837_dystrophic_cardiac_calcinosis1.02939821
88MP0005645_abnormal_hypothalamus_physiol1.02267248
89MP0003942_abnormal_urinary_system1.02074643
90MP0000751_myopathy1.01631378
91MP0003861_abnormal_nervous_system1.00557887
92MP0008789_abnormal_olfactory_epithelium0.99668892
93MP0003315_abnormal_perineum_morphology0.99627625
94MP0005187_abnormal_penis_morphology0.98001339
95MP0005195_abnormal_posterior_eye0.97955228
96MP0002822_catalepsy0.97544953
97MP0009250_abnormal_appendicular_skeleto0.96624523
98MP0002229_neurodegeneration0.95338870
99MP0002751_abnormal_autonomic_nervous0.95297802
100MP0003879_abnormal_hair_cell0.94291454
101MP0002249_abnormal_larynx_morphology0.93816312
102MP0009379_abnormal_foot_pigmentation0.92928121
103MP0003567_abnormal_fetal_cardiomyocyte0.92726432
104MP0001502_abnormal_circadian_rhythm0.89992471
105MP0005623_abnormal_meninges_morphology0.89823307
106MP0005391_vision/eye_phenotype0.88384213
107MP0002697_abnormal_eye_size0.88265515
108MP0003137_abnormal_impulse_conducting0.85266476
109MP0004484_altered_response_of0.84117875
110MP0000026_abnormal_inner_ear0.82748987
111MP0000534_abnormal_ureter_morphology0.82512686
112MP0001177_atelectasis0.81865627
113MP0004085_abnormal_heartbeat0.81110073
114MP0005248_abnormal_Harderian_gland0.80251899
115MP0003755_abnormal_palate_morphology0.78093169
116MP0003935_abnormal_craniofacial_develop0.77639694
117MP0000647_abnormal_sebaceous_gland0.76032758
118MP0002163_abnormal_gland_morphology0.75540301
119MP0002069_abnormal_eating/drinking_beha0.74491404
120MP0001943_abnormal_respiration0.74388452
121MP0002909_abnormal_adrenal_gland0.73082373
122MP0002082_postnatal_lethality0.69933516
123MP0010770_preweaning_lethality0.69933516
124MP0010769_abnormal_survival0.66913658
125MP0003937_abnormal_limbs/digits/tail_de0.63591422
126MP0002081_perinatal_lethality0.62943012
127MP0003950_abnormal_plasma_membrane0.62103909
128MP0010768_mortality/aging0.61587140
129MP0003123_paternal_imprinting0.61328728
130MP0006292_abnormal_olfactory_placode0.61141260
131MP0002233_abnormal_nose_morphology0.61053158

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.98571097
2Epileptic encephalopathy (HP:0200134)4.54458049
3Focal seizures (HP:0007359)4.38544531
4Hyperventilation (HP:0002883)4.38285213
5Myokymia (HP:0002411)4.08195116
6Insidious onset (HP:0003587)3.96318418
7Termporal pattern (HP:0011008)3.96318418
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.95467429
9Degeneration of the lateral corticospinal tracts (HP:0002314)3.95467429
10Atonic seizures (HP:0010819)3.95254395
11Abnormality of the corticospinal tract (HP:0002492)3.94435832
12Abnormal hair whorl (HP:0010721)3.78888981
13Progressive cerebellar ataxia (HP:0002073)3.68498615
14Broad-based gait (HP:0002136)3.44215796
15Dialeptic seizures (HP:0011146)3.37965035
16Absence seizures (HP:0002121)3.21777979
17Visual hallucinations (HP:0002367)3.14927119
18Scanning speech (HP:0002168)3.11261439
19Febrile seizures (HP:0002373)3.06918032
20Generalized tonic-clonic seizures (HP:0002069)3.01867175
21Excessive salivation (HP:0003781)2.99835193
22Drooling (HP:0002307)2.99835193
23Absent speech (HP:0001344)2.98983991
24Pheochromocytoma (HP:0002666)2.98778398
25Neurofibrillary tangles (HP:0002185)2.96381847
26Medial flaring of the eyebrow (HP:0010747)2.95998600
27Congenital primary aphakia (HP:0007707)2.90338654
28Urinary urgency (HP:0000012)2.89561350
29Ankle clonus (HP:0011448)2.88838151
30Spastic gait (HP:0002064)2.84005269
31Poor eye contact (HP:0000817)2.83394648
32Retinal dysplasia (HP:0007973)2.81850413
33Urinary bladder sphincter dysfunction (HP:0002839)2.81361958
34Impaired vibration sensation in the lower limbs (HP:0002166)2.78050478
35Dysmetria (HP:0001310)2.77515875
36Clumsiness (HP:0002312)2.76583522
37True hermaphroditism (HP:0010459)2.75331909
38Nephrogenic diabetes insipidus (HP:0009806)2.72390168
39Cerebral inclusion bodies (HP:0100314)2.67441239
40Nephronophthisis (HP:0000090)2.66151605
41Meningioma (HP:0002858)2.64773305
42Dysdiadochokinesis (HP:0002075)2.64490722
43Oligodactyly (hands) (HP:0001180)2.58832661
44Action tremor (HP:0002345)2.58038608
45Lissencephaly (HP:0001339)2.54721015
46Abnormal social behavior (HP:0012433)2.52981427
47Impaired social interactions (HP:0000735)2.52981427
48Neuroendocrine neoplasm (HP:0100634)2.52322055
49Truncal ataxia (HP:0002078)2.49829516
50Anophthalmia (HP:0000528)2.48710607
51Pancreatic fibrosis (HP:0100732)2.44546103
52Gaze-evoked nystagmus (HP:0000640)2.44372651
53Genetic anticipation (HP:0003743)2.42230926
54Abnormality of midbrain morphology (HP:0002418)2.38901428
55Molar tooth sign on MRI (HP:0002419)2.38901428
56Optic nerve hypoplasia (HP:0000609)2.37603464
57Supranuclear gaze palsy (HP:0000605)2.37594057
58Cortical dysplasia (HP:0002539)2.37128070
59Epileptiform EEG discharges (HP:0011182)2.36136166
60Hepatoblastoma (HP:0002884)2.28470041
61Aplasia/Hypoplasia of the brainstem (HP:0007362)2.26698682
62Hypoplasia of the brainstem (HP:0002365)2.26698682
63Protruding tongue (HP:0010808)2.25955546
64Amblyopia (HP:0000646)2.24896575
65Inability to walk (HP:0002540)2.24038341
66EEG with generalized epileptiform discharges (HP:0011198)2.24018084
67Abnormality of the labia minora (HP:0012880)2.22548380
68Chronic hepatic failure (HP:0100626)2.21511513
69Abnormality of salivation (HP:0100755)2.20612436
70Pancreatic cysts (HP:0001737)2.19615549
71Septo-optic dysplasia (HP:0100842)2.18926192
72Poor coordination (HP:0002370)2.16869833
73Hypsarrhythmia (HP:0002521)2.16095378
74Lower limb muscle weakness (HP:0007340)2.14239024
75Abnormal eating behavior (HP:0100738)2.13449849
76Blue irides (HP:0000635)2.10885266
77Abnormality of the renal medulla (HP:0100957)2.10740061
78Cutaneous finger syndactyly (HP:0010554)2.10473560
79Pachygyria (HP:0001302)2.08555069
80Mutism (HP:0002300)2.07272788
81Morphological abnormality of the middle ear (HP:0008609)2.06648539
82Split foot (HP:0001839)2.06496091
83Generalized myoclonic seizures (HP:0002123)2.06125422
84Gait imbalance (HP:0002141)2.04442593
85Stereotypic behavior (HP:0000733)2.04322856
86Postaxial hand polydactyly (HP:0001162)2.03424411
87Akinesia (HP:0002304)2.03274243
88Broad foot (HP:0001769)2.02179630
89Alacrima (HP:0000522)2.01398777
90Oligodactyly (HP:0012165)2.01326849
91Anteriorly placed anus (HP:0001545)1.97824093
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97758975
93Intention tremor (HP:0002080)1.97540187
94Fair hair (HP:0002286)1.96571732
95Vitreoretinal degeneration (HP:0000655)1.96202177
96Anencephaly (HP:0002323)1.96084492
97Inappropriate behavior (HP:0000719)1.94060470
98Type II lissencephaly (HP:0007260)1.92903704
99Exotropia (HP:0000577)1.92708283
100Spastic tetraplegia (HP:0002510)1.92628238
101Progressive inability to walk (HP:0002505)1.92350209
102Intestinal atresia (HP:0011100)1.92162057
103Cutaneous syndactyly (HP:0012725)1.89215579
104Widely spaced teeth (HP:0000687)1.89177160
105Depression (HP:0000716)1.87935254
106Polyphagia (HP:0002591)1.85884456
107Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85725741
108Short 4th metacarpal (HP:0010044)1.85725741
109Megalencephaly (HP:0001355)1.85381860
110Labial hypoplasia (HP:0000066)1.85265562
111Fetal akinesia sequence (HP:0001989)1.84572362
112Peripheral hypomyelination (HP:0007182)1.84570210
113Morphological abnormality of the pyramidal tract (HP:0002062)1.83723644
114Limb dystonia (HP:0002451)1.82883402
115Anxiety (HP:0000739)1.82754624
116Agitation (HP:0000713)1.82720719
117Abnormal mitochondria in muscle tissue (HP:0008316)1.82147887
118Esotropia (HP:0000565)1.82089015
119Gastroesophageal reflux (HP:0002020)1.81207762
120Amyotrophic lateral sclerosis (HP:0007354)1.80474878
121Occipital encephalocele (HP:0002085)1.80289362
122Renal hypoplasia (HP:0000089)1.79499290
123Synostosis involving the elbow (HP:0003938)1.78879570
124Humeroradial synostosis (HP:0003041)1.78879570
125Postaxial foot polydactyly (HP:0001830)1.77374225
126Sclerocornea (HP:0000647)1.77121012
127Abnormality of the lower motor neuron (HP:0002366)1.76692758
128Neoplasm of the peripheral nervous system (HP:0100007)1.76385306
129Narrow forehead (HP:0000341)1.76246711
130Sensory axonal neuropathy (HP:0003390)1.75705775
131Genital tract atresia (HP:0001827)1.74135837
132Vaginal atresia (HP:0000148)1.73709043
133Hemiparesis (HP:0001269)1.73611466
134Micropenis (HP:0000054)1.73045765
135Meningocele (HP:0002435)1.73002594
136Colon cancer (HP:0003003)1.72454786
137Intellectual disability, moderate (HP:0002342)1.69336671
138Thyroid-stimulating hormone excess (HP:0002925)1.69274894
139Hypercortisolism (HP:0001578)1.67760116
140Myelomeningocele (HP:0002475)1.66549296
141Hydroureter (HP:0000072)1.66517980
142Aplasia/Hypoplasia of the lens (HP:0008063)1.66212976
143Steppage gait (HP:0003376)1.65562533
144Hypoplastic female external genitalia (HP:0012815)1.65529397
145Impaired vibratory sensation (HP:0002495)1.65525626
146Clonus (HP:0002169)1.65009180
147Preaxial hand polydactyly (HP:0001177)1.64008875
148Hypoplasia of the corpus callosum (HP:0002079)1.63331606
149Thickened helices (HP:0000391)1.63306269
150Cupped ear (HP:0000378)1.63297861
151Aqueductal stenosis (HP:0002410)1.62350774
152Abnormal lung lobation (HP:0002101)1.62115094
153Bowel incontinence (HP:0002607)1.61193280
154Sporadic (HP:0003745)1.60521122
155Incomplete penetrance (HP:0003829)1.60260996
156Obstructive sleep apnea (HP:0002870)1.60236485
157Specific learning disability (HP:0001328)1.60081328
158Decreased lacrimation (HP:0000633)1.59741667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.79397409
2MARK13.72692362
3EPHA43.31417848
4MAP3K43.19202439
5NTRK32.67393789
6PNCK2.46672069
7MAP2K72.42137179
8DAPK22.16308204
9EPHB22.10972908
10MINK12.10961204
11PLK22.10560308
12STK392.09629957
13OXSR12.05149209
14NTRK21.95077744
15MAP3K91.89375476
16PRPF4B1.85796608
17PINK11.83223722
18TNIK1.79255965
19MAP4K21.74827260
20MAPK131.73246909
21NTRK11.71298984
22MAP2K41.69991610
23KSR11.59547920
24CSNK1G21.54305054
25CDK191.54158227
26PAK61.45335561
27CSNK1G31.42417389
28UHMK11.42249329
29BMPR21.41760549
30CDK51.33565739
31CSNK1A1L1.33420906
32PKN11.32457621
33DYRK31.28150055
34MAP3K121.25497577
35FGR1.15800841
36CAMKK21.15043669
37DYRK1B1.12069709
38TRIM281.09386308
39CAMK2B1.08930907
40EPHA31.07849371
41CAMK2A1.06604173
42BMPR1B1.03311804
43FES1.02644871
44SGK21.01210686
45CCNB10.99656180
46BCR0.99120948
47STK110.98924884
48DYRK20.97732882
49CSNK1G10.97361693
50GRK50.97349629
51TYRO30.97237647
52PHKG20.95758080
53PHKG10.95758080
54FGFR20.95303665
55STK160.94122127
56PRKCG0.93263682
57MUSK0.92967724
58WNK10.92816297
59MET0.92443810
60SGK4940.91566979
61SGK2230.91566979
62MAP3K60.89392506
63ROCK20.88187222
64DAPK10.86704434
65PAK30.84543893
66CDK180.83721753
67LIMK10.82861622
68CDK140.82106283
69CDK150.81366432
70ERBB40.81217306
71LATS20.80979053
72INSRR0.76544952
73KSR20.75843369
74ERBB30.75793748
75PRKCE0.75392251
76WNK30.74782413
77CAMK1G0.73333160
78TNK20.69638978
79MKNK10.69324138
80STK38L0.68828265
81CDK30.67130197
82BRD40.66912412
83CDK11A0.66790787
84PDPK10.66377459
85PDK10.65718481
86MAPK120.65312116
87PTK2B0.64951493
88CAMKK10.64695695
89RET0.64427003
90MAPK150.61864601
91NUAK10.61705290
92CAMK2D0.60972030
93MST1R0.60609278
94SIK20.59339241
95ADRBK20.58679811
96SRPK10.56305901
97MAP3K20.54978014
98CAMK40.54532953
99RPS6KA40.54472259
100DMPK0.53715834
101BRSK20.53410154
102PRKCH0.52490933
103ERBB20.52168235
104SGK10.49991198
105PRKCZ0.49970191
106MARK20.49379600
107CAMK2G0.48419005
108DYRK1A0.47342246
109CSNK1D0.44993379
110ADRBK10.44858375
111BMX0.44461522
112PRKD30.43869232
113WNK40.43589123
114RIPK40.43309987
115FYN0.42946836
116MAPK100.42606585
117MKNK20.42550221
118CDC70.41764160
119ZAK0.41068370
120CAMK10.40961533
121ALK0.40743132
122CSNK1E0.40589433
123RPS6KA20.40505969
124PRKG10.40357657
125FGFR10.40195504
126SGK30.40175153
127BRSK10.38075139
128TLK10.37414536
129GRK10.36940599
130PRKACA0.36755671
131PRKACB0.36732004
132RPS6KA30.36680081
133FRK0.35621644
134PLK40.33651927
135TIE10.32369582
136MAP3K50.32312646
137PLK30.31987596

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.29246309
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68018264
3Glutamatergic synapse_Homo sapiens_hsa047242.64426583
4GABAergic synapse_Homo sapiens_hsa047272.62087409
5Synaptic vesicle cycle_Homo sapiens_hsa047212.60285197
6Long-term potentiation_Homo sapiens_hsa047202.50478954
7Circadian entrainment_Homo sapiens_hsa047132.40424193
8Morphine addiction_Homo sapiens_hsa050322.34890405
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24821315
10Serotonergic synapse_Homo sapiens_hsa047262.06305324
11Dopaminergic synapse_Homo sapiens_hsa047282.04122586
12Axon guidance_Homo sapiens_hsa043601.97516111
13Long-term depression_Homo sapiens_hsa047301.95803633
14Salivary secretion_Homo sapiens_hsa049701.95202952
15Amphetamine addiction_Homo sapiens_hsa050311.94876124
16Taste transduction_Homo sapiens_hsa047421.87424936
17Olfactory transduction_Homo sapiens_hsa047401.84426928
18Cholinergic synapse_Homo sapiens_hsa047251.84358239
19Renin secretion_Homo sapiens_hsa049241.66230640
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62814492
21Collecting duct acid secretion_Homo sapiens_hsa049661.60915168
22Gastric acid secretion_Homo sapiens_hsa049711.59185301
23Insulin secretion_Homo sapiens_hsa049111.53437172
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51301662
25Cocaine addiction_Homo sapiens_hsa050301.46625015
26Oxytocin signaling pathway_Homo sapiens_hsa049211.41514616
27Protein export_Homo sapiens_hsa030601.41213365
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41051748
29ErbB signaling pathway_Homo sapiens_hsa040121.40513122
30Gap junction_Homo sapiens_hsa045401.37881868
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33437383
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26991989
33Calcium signaling pathway_Homo sapiens_hsa040201.25264589
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24494902
35GnRH signaling pathway_Homo sapiens_hsa049121.19751489
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18922101
37Vibrio cholerae infection_Homo sapiens_hsa051101.18246256
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12633836
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10707977
40Melanogenesis_Homo sapiens_hsa049161.10453020
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08305222
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06314527
43Phototransduction_Homo sapiens_hsa047441.04641725
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03569273
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03014091
46Basal transcription factors_Homo sapiens_hsa030221.02428388
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00619860
48Steroid biosynthesis_Homo sapiens_hsa001001.00606895
49Glioma_Homo sapiens_hsa052141.00510625
50Cardiac muscle contraction_Homo sapiens_hsa042600.99624643
51Alzheimers disease_Homo sapiens_hsa050100.98578564
52Oxidative phosphorylation_Homo sapiens_hsa001900.98391059
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98309150
54cAMP signaling pathway_Homo sapiens_hsa040240.97847439
55Fatty acid elongation_Homo sapiens_hsa000620.97385984
56Dorso-ventral axis formation_Homo sapiens_hsa043200.97329628
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96174482
58Estrogen signaling pathway_Homo sapiens_hsa049150.93861060
59Regulation of autophagy_Homo sapiens_hsa041400.92038225
60Renal cell carcinoma_Homo sapiens_hsa052110.91813960
61Butanoate metabolism_Homo sapiens_hsa006500.89558732
62Oocyte meiosis_Homo sapiens_hsa041140.88373147
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82319943
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.82220950
65Dilated cardiomyopathy_Homo sapiens_hsa054140.81157803
66Ras signaling pathway_Homo sapiens_hsa040140.81093779
67Wnt signaling pathway_Homo sapiens_hsa043100.79962833
68MAPK signaling pathway_Homo sapiens_hsa040100.79551785
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79140159
70Type II diabetes mellitus_Homo sapiens_hsa049300.73919833
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.73916486
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73623760
73Parkinsons disease_Homo sapiens_hsa050120.72420786
74Ether lipid metabolism_Homo sapiens_hsa005650.71080947
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.69782066
76Rap1 signaling pathway_Homo sapiens_hsa040150.69336828
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68209952
78Ovarian steroidogenesis_Homo sapiens_hsa049130.66307496
79Propanoate metabolism_Homo sapiens_hsa006400.65696521
80Hedgehog signaling pathway_Homo sapiens_hsa043400.65444801
81Fanconi anemia pathway_Homo sapiens_hsa034600.64347370
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63942975
83Pancreatic secretion_Homo sapiens_hsa049720.63837339
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63723514
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63591286
86Thyroid hormone synthesis_Homo sapiens_hsa049180.62136874
87Non-small cell lung cancer_Homo sapiens_hsa052230.62081926
88Nitrogen metabolism_Homo sapiens_hsa009100.62077087
89Alcoholism_Homo sapiens_hsa050340.60735820
90Choline metabolism in cancer_Homo sapiens_hsa052310.57397680
91mRNA surveillance pathway_Homo sapiens_hsa030150.56682125
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55257855
93RNA degradation_Homo sapiens_hsa030180.53451110
94Endometrial cancer_Homo sapiens_hsa052130.52657047
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.51909060
96Tight junction_Homo sapiens_hsa045300.50916497
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49634383
98TGF-beta signaling pathway_Homo sapiens_hsa043500.49498022
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48226627
100Circadian rhythm_Homo sapiens_hsa047100.47976920
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46746771
102VEGF signaling pathway_Homo sapiens_hsa043700.45990605
103Sulfur metabolism_Homo sapiens_hsa009200.45093360
104Huntingtons disease_Homo sapiens_hsa050160.45047700
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44990863
106Linoleic acid metabolism_Homo sapiens_hsa005910.44353133
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42619372
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42376821
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41523737
110Melanoma_Homo sapiens_hsa052180.40519212
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40511949
112Phagosome_Homo sapiens_hsa041450.38800539
113Vitamin B6 metabolism_Homo sapiens_hsa007500.37607163
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35401802
115Colorectal cancer_Homo sapiens_hsa052100.35132635
116Basal cell carcinoma_Homo sapiens_hsa052170.34405982
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33313326
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33218417
119beta-Alanine metabolism_Homo sapiens_hsa004100.31968608
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31051397
121Peroxisome_Homo sapiens_hsa041460.30689552
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.29538322
123Endocytosis_Homo sapiens_hsa041440.29187464
124Hippo signaling pathway_Homo sapiens_hsa043900.28169306
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28058275

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