PUS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.15213336
2DNA deamination (GO:0045006)5.13656016
3formation of translation preinitiation complex (GO:0001731)4.82129354
4DNA strand elongation involved in DNA replication (GO:0006271)4.62167299
5nucleobase biosynthetic process (GO:0046112)4.40431796
6maturation of SSU-rRNA (GO:0030490)4.38669537
7DNA strand elongation (GO:0022616)4.38318791
8telomere maintenance via semi-conservative replication (GO:0032201)4.34481583
9rRNA methylation (GO:0031167)4.28895479
10* tRNA modification (GO:0006400)4.27550775
11viral transcription (GO:0019083)4.27363639
12DNA unwinding involved in DNA replication (GO:0006268)4.25947903
13tRNA methylation (GO:0030488)4.25515214
14translational termination (GO:0006415)4.18375344
15DNA replication initiation (GO:0006270)4.16972474
16ribosome biogenesis (GO:0042254)4.15346912
17purine nucleobase biosynthetic process (GO:0009113)3.99351818
18ribonucleoprotein complex biogenesis (GO:0022613)3.99007688
19ribosomal large subunit biogenesis (GO:0042273)3.95051007
20translational elongation (GO:0006414)3.94060718
21ribosomal small subunit biogenesis (GO:0042274)3.91779684
22folic acid-containing compound biosynthetic process (GO:0009396)3.91193709
23translational initiation (GO:0006413)3.79256715
24telomere maintenance via recombination (GO:0000722)3.79240009
25IMP biosynthetic process (GO:0006188)3.76607569
26regulation of mitochondrial translation (GO:0070129)3.68790941
27DNA replication checkpoint (GO:0000076)3.62604354
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.61436171
29protein localization to kinetochore (GO:0034501)3.61353562
30replication fork processing (GO:0031297)3.59054182
31* ncRNA processing (GO:0034470)3.55164658
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.52257678
33mitotic recombination (GO:0006312)3.51431769
34peptidyl-histidine modification (GO:0018202)3.51240873
35IMP metabolic process (GO:0046040)3.50685210
36protein targeting to ER (GO:0045047)3.49956785
37cotranslational protein targeting to membrane (GO:0006613)3.48990823
38mitotic nuclear envelope disassembly (GO:0007077)3.48323956
39rRNA processing (GO:0006364)3.47868702
40telomere maintenance via telomere lengthening (GO:0010833)3.45222892
41meiotic chromosome segregation (GO:0045132)3.44254830
42folic acid metabolic process (GO:0046655)3.44026822
43* tRNA processing (GO:0008033)3.39502028
44transcription from mitochondrial promoter (GO:0006390)3.37373160
45rRNA metabolic process (GO:0016072)3.36362121
46mitotic metaphase plate congression (GO:0007080)3.34356452
47ribosome assembly (GO:0042255)3.33828737
48regulation of translational fidelity (GO:0006450)3.33099568
49viral life cycle (GO:0019058)3.31699898
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30383665
51protein localization to endoplasmic reticulum (GO:0070972)3.29792552
52maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.28627413
53RNA methylation (GO:0001510)3.26250048
54* RNA modification (GO:0009451)3.25910629
55proteasome assembly (GO:0043248)3.24126030
56* ncRNA metabolic process (GO:0034660)3.22365406
57cellular protein complex disassembly (GO:0043624)3.21515316
58* pseudouridine synthesis (GO:0001522)3.20130547
59GDP-mannose metabolic process (GO:0019673)3.19836059
60mitochondrial DNA metabolic process (GO:0032042)3.19190307
61nuclear envelope disassembly (GO:0051081)3.18964687
62membrane disassembly (GO:0030397)3.18964687
63mitochondrial DNA replication (GO:0006264)3.18148474
64rRNA transcription (GO:0009303)3.16045164
65spliceosomal snRNP assembly (GO:0000387)3.13275790
66translation (GO:0006412)3.10963894
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.10291551
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09294892
69DNA strand renaturation (GO:0000733)3.07876219
70respiratory chain complex IV assembly (GO:0008535)3.06916277
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06247678
72* tRNA metabolic process (GO:0006399)3.05187458
73negative regulation of mRNA metabolic process (GO:1903312)3.04118946
74protein localization to chromosome, centromeric region (GO:0071459)3.03397981
75protein K6-linked ubiquitination (GO:0085020)2.98404069
76cellular component biogenesis (GO:0044085)2.97962013
77DNA replication-dependent nucleosome assembly (GO:0006335)2.97573488
78DNA replication-dependent nucleosome organization (GO:0034723)2.97573488
79mitochondrial RNA metabolic process (GO:0000959)2.97093861
80rRNA modification (GO:0000154)2.96798033
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93843527
82protein complex disassembly (GO:0043241)2.93380946
83nuclear-transcribed mRNA catabolic process (GO:0000956)2.92716335
84pteridine-containing compound biosynthetic process (GO:0042559)2.92692221
85cytochrome complex assembly (GO:0017004)2.92486279
86CENP-A containing nucleosome assembly (GO:0034080)2.91570047
87regulation of translational termination (GO:0006449)2.91315425
88UTP biosynthetic process (GO:0006228)2.91230914
89transcription elongation from RNA polymerase I promoter (GO:0006362)2.89784166
90chromatin remodeling at centromere (GO:0031055)2.89476616
91termination of RNA polymerase I transcription (GO:0006363)2.88345669
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86794437
93somatic hypermutation of immunoglobulin genes (GO:0016446)2.86794437
94nuclear pore organization (GO:0006999)2.85635775
95viral mRNA export from host cell nucleus (GO:0046784)2.84549825
96negative regulation of RNA splicing (GO:0033119)2.83790820
97DNA duplex unwinding (GO:0032508)2.83782078
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83656434
99metaphase plate congression (GO:0051310)2.83090054
100deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82587057
101DNA geometric change (GO:0032392)2.81459447
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80020854
103ncRNA 3-end processing (GO:0043628)2.79215124
104RNA catabolic process (GO:0006401)2.78774257
105mRNA catabolic process (GO:0006402)2.78475578
106mitotic sister chromatid segregation (GO:0000070)2.78323647
107macromolecular complex disassembly (GO:0032984)2.77893816
108double-strand break repair via homologous recombination (GO:0000724)2.77137790
109pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.76555955
110transcription from RNA polymerase I promoter (GO:0006360)2.76551657
111regulation of double-strand break repair via homologous recombination (GO:0010569)2.76291393
112cell cycle G1/S phase transition (GO:0044843)2.75937639
113G1/S transition of mitotic cell cycle (GO:0000082)2.75937639
114recombinational repair (GO:0000725)2.75899058
115positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75699348
116DNA-templated transcription, termination (GO:0006353)2.75560929
117transcription elongation from RNA polymerase III promoter (GO:0006385)2.74389271
118termination of RNA polymerase III transcription (GO:0006386)2.74389271
119pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.73180446
120regulation of nuclear cell cycle DNA replication (GO:0033262)2.71432297
121pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.70589724
122maturation of 5.8S rRNA (GO:0000460)2.69554712
123chromatin assembly (GO:0031497)2.69392348
124termination of RNA polymerase II transcription (GO:0006369)2.69077766
125negative regulation of ligase activity (GO:0051352)2.69027033
126negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69027033
127DNA replication-independent nucleosome organization (GO:0034724)2.68529918
128DNA replication-independent nucleosome assembly (GO:0006336)2.68529918
129proline biosynthetic process (GO:0006561)2.67877234
130DNA-dependent DNA replication (GO:0006261)2.65507305
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65143396
132cellular response to ATP (GO:0071318)2.64995173
133regulation of translation in response to stress (GO:0043555)2.63971830
134telomere organization (GO:0032200)2.63248534
135heterochromatin organization (GO:0070828)2.63243522
136telomere maintenance (GO:0000723)2.62433417
137negative regulation of mRNA processing (GO:0050686)2.62036595
138DNA replication (GO:0006260)2.58894366
139RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.57444025
140mRNA splicing, via spliceosome (GO:0000398)2.56919037
141RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.56919037
142peptidyl-arginine omega-N-methylation (GO:0035247)2.54482641
143regulation of gene silencing by RNA (GO:0060966)2.53931563
144regulation of posttranscriptional gene silencing (GO:0060147)2.53931563
145regulation of gene silencing by miRNA (GO:0060964)2.53931563
146RNA splicing, via transesterification reactions (GO:0000375)2.53432661
147DNA recombination (GO:0006310)2.53413938
148DNA catabolic process, exonucleolytic (GO:0000738)2.52236076
149histone arginine methylation (GO:0034969)2.50302995
150mitochondrial respiratory chain complex assembly (GO:0033108)2.48303269
151UTP metabolic process (GO:0046051)2.48257915
152alternative mRNA splicing, via spliceosome (GO:0000380)2.46714995
153mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.45590783
154mitochondrial respiratory chain complex I assembly (GO:0032981)2.45590783
155NADH dehydrogenase complex assembly (GO:0010257)2.45590783
156tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.45493039
157RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.45493039
158regulation of centrosome cycle (GO:0046605)2.45462889
159pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.44907688
160snRNA transcription (GO:0009301)2.44740104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93006778
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.19671914
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91972036
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.84372392
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82679759
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81377349
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80647994
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71293853
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.66705369
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66584840
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.65200951
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62046369
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59085677
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.51423057
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38420935
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32199197
17XRN2_22483619_ChIP-Seq_HELA_Human2.19911675
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15491470
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13073493
20VDR_23849224_ChIP-Seq_CD4+_Human2.03358162
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01345784
22E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96178477
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91859482
24* MYC_22102868_ChIP-Seq_BL_Human1.91410874
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89324201
26DCP1A_22483619_ChIP-Seq_HELA_Human1.88132942
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86429784
28FOXP3_21729870_ChIP-Seq_TREG_Human1.81761874
29GABP_19822575_ChIP-Seq_HepG2_Human1.80166529
30* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80017930
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.71973995
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68382565
33AR_21909140_ChIP-Seq_LNCAP_Human1.65871801
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63796208
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63552724
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63503388
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63447248
38TTF2_22483619_ChIP-Seq_HELA_Human1.61400449
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61214487
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.60514132
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56812287
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.55707472
43CIITA_25753668_ChIP-Seq_RAJI_Human1.55504350
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55047700
45* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51730998
46MYC_18940864_ChIP-ChIP_HL60_Human1.50773307
47P68_20966046_ChIP-Seq_HELA_Human1.50571364
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.50343310
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47824826
50VDR_21846776_ChIP-Seq_THP-1_Human1.44985614
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43791280
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42228961
53KDM5A_27292631_Chip-Seq_BREAST_Human1.41760244
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40374099
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.37173869
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36919203
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36001901
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34529107
59FOXP1_21924763_ChIP-Seq_HESCs_Human1.33999570
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.31671890
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31521423
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31314067
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30996359
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28753703
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27331451
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27129769
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.26479011
68ELK1_19687146_ChIP-ChIP_HELA_Human1.26161017
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26013739
70* MAF_26560356_Chip-Seq_TH2_Human1.25664076
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25454970
72PHF8_20622854_ChIP-Seq_HELA_Human1.25135724
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23943699
74TFEB_21752829_ChIP-Seq_HELA_Human1.23144996
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21951463
76* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19444609
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18859210
78* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18794220
79E2F1_20622854_ChIP-Seq_HELA_Human1.17445908
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16419697
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13218100
82BCOR_27268052_Chip-Seq_Bcells_Human1.12692954
83BCL6_27268052_Chip-Seq_Bcells_Human1.11458015
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10187525
85* NOTCH1_21737748_ChIP-Seq_TLL_Human1.09910278
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08763561
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06439786
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05849110
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04647227
90SPI1_23547873_ChIP-Seq_NB4_Human1.04470706
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03466365
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.02736486
93* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01553647
94MAF_26560356_Chip-Seq_TH1_Human1.01373661
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01149542
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99645173
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95262805
98RARB_24833708_ChIP-Seq_LIVER_Mouse0.94369435
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94224059
100ZNF263_19887448_ChIP-Seq_K562_Human0.94026398
101GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93318147
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93172025
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92895684
104* RARA_24833708_ChIP-Seq_LIVER_Mouse0.92842857
105CTCF_26484167_Chip-Seq_Bcells_Mouse0.92516307
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92333379
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91557683
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90282895
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90265401
110MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88862936
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88066008
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87828149
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87449007
114* PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87316300
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87145308
116PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86345716
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84680180
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84130429
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83981024
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83658834
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.83333367
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83039300
123OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82954100
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80747451
125ELK1_22589737_ChIP-Seq_MCF10A_Human0.79414783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.42897261
2MP0004957_abnormal_blastocyst_morpholog3.98618559
3MP0010094_abnormal_chromosome_stability3.80349927
4MP0003111_abnormal_nucleus_morphology3.67922533
5MP0008057_abnormal_DNA_replication3.38876504
6MP0003077_abnormal_cell_cycle3.26432599
7MP0002396_abnormal_hematopoietic_system2.78513700
8MP0008058_abnormal_DNA_repair2.59589326
9MP0010352_gastrointestinal_tract_polyps2.48094483
10MP0008007_abnormal_cellular_replicative2.42314093
11MP0003806_abnormal_nucleotide_metabolis2.42305588
12MP0002254_reproductive_system_inflammat2.26627575
13MP0001986_abnormal_taste_sensitivity2.18213132
14MP0008932_abnormal_embryonic_tissue2.07444676
15MP0001730_embryonic_growth_arrest2.07201681
16MP0000490_abnormal_crypts_of2.04402314
17MP0002138_abnormal_hepatobiliary_system2.02195878
18MP0003786_premature_aging1.89528136
19MP0000350_abnormal_cell_proliferation1.89295945
20MP0005174_abnormal_tail_pigmentation1.88728080
21MP0005397_hematopoietic_system_phenotyp1.88637599
22MP0001545_abnormal_hematopoietic_system1.88637599
23MP0006292_abnormal_olfactory_placode1.74839202
24MP0009333_abnormal_splenocyte_physiolog1.71285029
25MP0004808_abnormal_hematopoietic_stem1.69358031
26MP0005083_abnormal_biliary_tract1.65178631
27MP0010307_abnormal_tumor_latency1.59889018
28MP0001672_abnormal_embryogenesis/_devel1.53659481
29MP0005380_embryogenesis_phenotype1.53659481
30MP0003123_paternal_imprinting1.53108173
31MP0002019_abnormal_tumor_incidence1.53061447
32MP0003763_abnormal_thymus_physiology1.52882509
33MP0002160_abnormal_reproductive_system1.49464299
34MP0001697_abnormal_embryo_size1.48975911
35MP0001661_extended_life_span1.47481497
36MP0003186_abnormal_redox_activity1.47344877
37MP0002080_prenatal_lethality1.46011045
38MP0003984_embryonic_growth_retardation1.45549312
39MP0000313_abnormal_cell_death1.42558306
40MP0002088_abnormal_embryonic_growth/wei1.41294617
41MP0002163_abnormal_gland_morphology1.36878994
42MP0006036_abnormal_mitochondrial_physio1.34529593
43MP0001919_abnormal_reproductive_system1.32948204
44MP0000689_abnormal_spleen_morphology1.32506430
45MP0002086_abnormal_extraembryonic_tissu1.32496428
46MP0002398_abnormal_bone_marrow1.32307348
47MP0004185_abnormal_adipocyte_glucose1.32036581
48MP0002722_abnormal_immune_system1.29753112
49MP0006035_abnormal_mitochondrial_morpho1.29001268
50MP0005389_reproductive_system_phenotype1.28142562
51MP0003705_abnormal_hypodermis_morpholog1.25823270
52MP0003718_maternal_effect1.24750317
53MP0004197_abnormal_fetal_growth/weight/1.20871633
54MP0000358_abnormal_cell_content/1.20294983
55MP0003567_abnormal_fetal_cardiomyocyte1.19330130
56MP0005220_abnormal_exocrine_pancreas1.19207498
57MP0002132_abnormal_respiratory_system1.18464396
58MP0005645_abnormal_hypothalamus_physiol1.18228058
59MP0009840_abnormal_foam_cell1.16306544
60MP0000685_abnormal_immune_system1.15439729
61MP0009278_abnormal_bone_marrow1.14976798
62MP0000015_abnormal_ear_pigmentation1.13457434
63MP0001853_heart_inflammation1.12851572
64MP0002085_abnormal_embryonic_tissue1.12096748
65MP0001835_abnormal_antigen_presentation1.11928748
66MP0000703_abnormal_thymus_morphology1.10759000
67MP0002429_abnormal_blood_cell1.08687620
68MP0008877_abnormal_DNA_methylation1.07394003
69MP0001968_abnormal_touch/_nociception1.06850248
70MP0002084_abnormal_developmental_patter1.06652718
71MP0004133_heterotaxia1.04090226
72MP0005023_abnormal_wound_healing1.02112071
73MP0008995_early_reproductive_senescence1.01446431
74MP0000858_altered_metastatic_potential1.00917508
75MP0003566_abnormal_cell_adhesion1.00824102
76MP0001929_abnormal_gametogenesis0.98482525
77MP0008875_abnormal_xenobiotic_pharmacok0.96053098
78MP0005075_abnormal_melanosome_morpholog0.95411349
79MP0000716_abnormal_immune_system0.95361006
80MP0003221_abnormal_cardiomyocyte_apopto0.94905661
81MP0008872_abnormal_physiological_respon0.94308933
82MP0000470_abnormal_stomach_morphology0.94108244
83MP0010030_abnormal_orbit_morphology0.93133527
84MP0001800_abnormal_humoral_immune0.91418687
85MP0010155_abnormal_intestine_physiology0.91196588
86MP0005310_abnormal_salivary_gland0.88437652
87MP0002938_white_spotting0.87933928
88MP0006054_spinal_hemorrhage0.87282985
89MP0000678_abnormal_parathyroid_gland0.86883715
90MP0000598_abnormal_liver_morphology0.86499021
91MP0004043_abnormal_pH_regulation0.86468263
92MP0002405_respiratory_system_inflammati0.85503539
93MP0000653_abnormal_sex_gland0.83873836
94MP0002166_altered_tumor_susceptibility0.83808270
95MP0005671_abnormal_response_to0.83665979
96MP0005501_abnormal_skin_physiology0.83051642
97MP0003136_yellow_coat_color0.82720700
98MP0000477_abnormal_intestine_morphology0.82538311
99MP0005266_abnormal_metabolism0.82328102
100MP0004381_abnormal_hair_follicle0.81306622
101MP0005076_abnormal_cell_differentiation0.80263729
102MP0002089_abnormal_postnatal_growth/wei0.80212489
103MP0004233_abnormal_muscle_weight0.79738242
104MP0002693_abnormal_pancreas_physiology0.79677508
105MP0003436_decreased_susceptibility_to0.78572483
106MP0003656_abnormal_erythrocyte_physiolo0.78461775
107MP0003195_calcinosis0.77848055
108MP0009672_abnormal_birth_weight0.77621694
109MP0002452_abnormal_antigen_presenting0.77505744
110MP0002420_abnormal_adaptive_immunity0.76959510
111MP0005464_abnormal_platelet_physiology0.76673922
112MP0001873_stomach_inflammation0.75671183
113MP0001819_abnormal_immune_cell0.75618536
114MP0005384_cellular_phenotype0.75327767
115MP0001293_anophthalmia0.75222347
116MP0005379_endocrine/exocrine_gland_phen0.73682937
117MP0003943_abnormal_hepatobiliary_system0.73429482
118MP0005319_abnormal_enzyme/_coenzyme0.72756588
119MP0000427_abnormal_hair_cycle0.72454635
120MP0001764_abnormal_homeostasis0.72402234
121MP0003698_abnormal_male_reproductive0.72135587
122MP0004264_abnormal_extraembryonic_tissu0.71438084
123MP0002723_abnormal_immune_serum0.71294375
124MP0005025_abnormal_response_to0.70295990
125MP0001145_abnormal_male_reproductive0.68516453
126MP0001119_abnormal_female_reproductive0.68233683
127MP0001944_abnormal_pancreas_morphology0.67894892
128MP0002736_abnormal_nociception_after0.67642863
129MP0001849_ear_inflammation0.66868803
130MP0005621_abnormal_cell_physiology0.66786607
131MP0005332_abnormal_amino_acid0.66692538
132MP0002210_abnormal_sex_determination0.66615225
133MP0003191_abnormal_cellular_cholesterol0.66613732
134MP0002006_tumorigenesis0.66417049
135MP0002970_abnormal_white_adipose0.66406648
136MP0001915_intracranial_hemorrhage0.66309298
137MP0002269_muscular_atrophy0.65998208
138MP0002139_abnormal_hepatobiliary_system0.65808946
139MP0002111_abnormal_tail_morphology0.65730637
140MP0002877_abnormal_melanocyte_morpholog0.63502331
141MP0000371_diluted_coat_color0.61591211
142MP0003866_abnormal_defecation0.61227410
143MP0009785_altered_susceptibility_to0.60727740
144MP0000609_abnormal_liver_physiology0.60369531

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of cells of the erythroid lineage (HP:0012130)4.61292456
2Reticulocytopenia (HP:0001896)4.35092599
3* Abnormal number of erythroid precursors (HP:0012131)4.22956339
4Birth length less than 3rd percentile (HP:0003561)4.19013321
5Pendular nystagmus (HP:0012043)3.66568868
6Thrombocytosis (HP:0001894)3.62584476
7Multiple enchondromatosis (HP:0005701)3.59551372
8Degeneration of anterior horn cells (HP:0002398)3.31238953
9Abnormality of the anterior horn cell (HP:0006802)3.31238953
10Oral leukoplakia (HP:0002745)3.26035127
11Aplastic anemia (HP:0001915)3.23312253
12Macrocytic anemia (HP:0001972)3.17398143
13Breast hypoplasia (HP:0003187)3.16949613
14Testicular atrophy (HP:0000029)3.07346847
15Selective tooth agenesis (HP:0001592)2.93981381
16Homocystinuria (HP:0002156)2.88300562
17Abnormality of homocysteine metabolism (HP:0010919)2.88300562
18Duplicated collecting system (HP:0000081)2.78617467
19Abnormality of DNA repair (HP:0003254)2.78467513
20* Pallor (HP:0000980)2.78205300
21Colon cancer (HP:0003003)2.78132589
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.70701300
23Absent thumb (HP:0009777)2.67742297
24Rough bone trabeculation (HP:0100670)2.67139522
2511 pairs of ribs (HP:0000878)2.66506490
26Microretrognathia (HP:0000308)2.66191231
27Attenuation of retinal blood vessels (HP:0007843)2.65494620
28Microvesicular hepatic steatosis (HP:0001414)2.64380124
29Trismus (HP:0000211)2.62870957
30Patellar aplasia (HP:0006443)2.54178171
31Carpal bone hypoplasia (HP:0001498)2.54009995
32Ependymoma (HP:0002888)2.52620861
33Short thumb (HP:0009778)2.52597463
34Abnormality of the renal collecting system (HP:0004742)2.52497044
35Reduced antithrombin III activity (HP:0001976)2.52009478
36Basal cell carcinoma (HP:0002671)2.49506146
37Ectopic kidney (HP:0000086)2.49258684
38Congenital stationary night blindness (HP:0007642)2.46286550
39Acute lymphatic leukemia (HP:0006721)2.45788206
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45575291
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45575291
42Aplasia/Hypoplasia of the patella (HP:0006498)2.43247745
43Abnormality of pyrimidine metabolism (HP:0004353)2.42539040
44Horseshoe kidney (HP:0000085)2.41014035
45Increased CSF lactate (HP:0002490)2.38152352
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.37101804
47Myelodysplasia (HP:0002863)2.35370809
48IgM deficiency (HP:0002850)2.30802532
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.30301427
50Petechiae (HP:0000967)2.28492541
51Abnormality of reticulocytes (HP:0004312)2.28310570
52Methylmalonic aciduria (HP:0012120)2.27910526
53Absent radius (HP:0003974)2.27740366
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.27156180
55Type I transferrin isoform profile (HP:0003642)2.26873854
56Intestinal fistula (HP:0100819)2.26747815
57Chromsome breakage (HP:0040012)2.25019919
58Lipid accumulation in hepatocytes (HP:0006561)2.23275656
59Medulloblastoma (HP:0002885)2.20450382
60Sparse eyelashes (HP:0000653)2.20197661
61Neoplasm of the pancreas (HP:0002894)2.19467234
62Rib fusion (HP:0000902)2.18602403
63Poikiloderma (HP:0001029)2.15752656
64Ketoacidosis (HP:0001993)2.15512805
65Pancreatic cysts (HP:0001737)2.15360241
66Ureteral duplication (HP:0000073)2.14683159
67Aplasia involving forearm bones (HP:0009822)2.14328789
68Absent forearm bone (HP:0003953)2.14328789
69Muscle fiber atrophy (HP:0100295)2.13798090
70Sloping forehead (HP:0000340)2.12991662
71Rectovaginal fistula (HP:0000143)2.12811540
72Rectal fistula (HP:0100590)2.12811540
73Cleft eyelid (HP:0000625)2.12603639
74Abnormality of alanine metabolism (HP:0010916)2.11736424
75Hyperalaninemia (HP:0003348)2.11736424
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11736424
77Impulsivity (HP:0100710)2.11085163
78Premature graying of hair (HP:0002216)2.10448038
79Abnormality of the carotid arteries (HP:0005344)2.09273513
80Clumsiness (HP:0002312)2.08838341
81Squamous cell carcinoma (HP:0002860)2.08102354
82Abnormality of the preputium (HP:0100587)2.06944169
83Pancytopenia (HP:0001876)2.06192500
84Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04897055
85Hypoplasia of the pons (HP:0012110)2.04574286
86Clubbing of toes (HP:0100760)2.04133040
87Cellular immunodeficiency (HP:0005374)2.01758725
88Rhabdomyosarcoma (HP:0002859)2.01268282
89Progressive microcephaly (HP:0000253)2.00707666
90Nausea (HP:0002018)2.00269224
91Cerebellar dysplasia (HP:0007033)1.99485461
92Mitochondrial inheritance (HP:0001427)1.98964045
93Type 2 muscle fiber atrophy (HP:0003554)1.98951214
94Abnormality of the ileum (HP:0001549)1.98945835
95Cerebral hypomyelination (HP:0006808)1.98242338
96Tongue fasciculations (HP:0001308)1.98025496
97Abnormality of chromosome stability (HP:0003220)1.97213098
98Abnormality of T cell physiology (HP:0011840)1.96962327
99Megaloblastic anemia (HP:0001889)1.96610344
100Overlapping toe (HP:0001845)1.95989393
101Meckel diverticulum (HP:0002245)1.95812592
102* Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95556289
103Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95512647
104Septate vagina (HP:0001153)1.95287391
105Atrophy/Degeneration involving motor neurons (HP:0007373)1.93726612
106Amaurosis fugax (HP:0100576)1.93610907
107Ketosis (HP:0001946)1.93352877
108Hepatocellular necrosis (HP:0001404)1.92897382
109Missing ribs (HP:0000921)1.92332964
110Type II lissencephaly (HP:0007260)1.92259028
111Hypergonadotropic hypogonadism (HP:0000815)1.91150470
112Lymphoma (HP:0002665)1.90116923
113Agnosia (HP:0010524)1.89969220
114Bone marrow hypocellularity (HP:0005528)1.89869920
115* Increased serum lactate (HP:0002151)1.89848686
116Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89556304
117Abnormal trabecular bone morphology (HP:0100671)1.87138559
118Vaginal fistula (HP:0004320)1.86487159
119Abnormality of midbrain morphology (HP:0002418)1.86304222
120Molar tooth sign on MRI (HP:0002419)1.86304222
121Protruding tongue (HP:0010808)1.86289376
122Slender long bone (HP:0003100)1.86122840
123Acute necrotizing encephalopathy (HP:0006965)1.85080944
124Prominent nose (HP:0000448)1.84889546
125Pustule (HP:0200039)1.83999628
126Abnormal rod and cone electroretinograms (HP:0008323)1.83839755
127Adenoma sebaceum (HP:0009720)1.82736339
128Angiofibromas (HP:0010615)1.82736339
129Bony spicule pigmentary retinopathy (HP:0007737)1.82537107
130Abnormal mitochondria in muscle tissue (HP:0008316)1.82297539
131Muscle fibrillation (HP:0010546)1.80683727
132Hypoplasia of the radius (HP:0002984)1.79335606
133Spinal muscular atrophy (HP:0007269)1.78935847
134Abnormal protein glycosylation (HP:0012346)1.77936023
135Abnormal glycosylation (HP:0012345)1.77936023
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77936023
137Abnormal protein N-linked glycosylation (HP:0012347)1.77936023
138Bilateral microphthalmos (HP:0007633)1.77208331
139Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77196781
140Dicarboxylic aciduria (HP:0003215)1.77196781
141Premature ovarian failure (HP:0008209)1.76868457
142Acute encephalopathy (HP:0006846)1.75752241
143Tubular atrophy (HP:0000092)1.74515178
144Glossoptosis (HP:0000162)1.74470864
145Abnormality of the motor neurons (HP:0002450)1.74204555
146Abnormal neuron morphology (HP:0012757)1.74204555
147Increased hepatocellular lipid droplets (HP:0006565)1.74116756
148Abnormal hemoglobin (HP:0011902)1.73310924
149Personality changes (HP:0000751)1.72507315
150Ragged-red muscle fibers (HP:0003200)1.72407437
151* Progressive muscle weakness (HP:0003323)1.71864821
152Abnormality of the umbilical cord (HP:0010881)1.70942161
153Hepatic necrosis (HP:0002605)1.70276746
154CNS hypomyelination (HP:0003429)1.70043420
155Abnormality of T cells (HP:0002843)1.69474269
156Poor head control (HP:0002421)1.67558020
157Elevated erythrocyte sedimentation rate (HP:0003565)1.65748509
158Abnormality of the pons (HP:0007361)1.65352475
159Abnormal number of incisors (HP:0011064)1.65078441
160Atresia of the external auditory canal (HP:0000413)1.62440437
161Nonimmune hydrops fetalis (HP:0001790)1.61062645

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.79689912
2BUB13.66706544
3WEE13.50247858
4SMG13.31209937
5NME23.10937746
6EIF2AK12.95296230
7CDC72.74032755
8EEF2K2.32326800
9PIM22.27386175
10NEK22.14036060
11EIF2AK32.13774955
12RPS6KB22.04071570
13MAP4K12.02216766
14FRK1.93908988
15ACVR1B1.92570010
16NEK11.83762977
17ICK1.78135222
18BRSK21.76995150
19STK161.74782472
20TSSK61.71308277
21MAP2K31.70551539
22MAP3K111.69344288
23BCKDK1.66306874
24PLK11.64766459
25FLT31.62675952
26DYRK31.59743104
27TAF11.59463484
28PKN21.58374501
29CDK71.57703265
30TTK1.57344046
31RPS6KA41.55210568
32SRPK11.53180885
33SCYL21.51416520
34PASK1.49276852
35MAP3K101.47726106
36ADRBK21.41280987
37VRK11.40922809
38PIM11.36380358
39TESK21.34553372
40CDK41.33852439
41AURKB1.33514948
42MKNK11.32560152
43WNK41.31331618
44NUAK11.31246070
45TGFBR11.31071985
46KDR1.30305077
47EPHA21.28365481
48PLK41.26623920
49MAP3K81.25912576
50ATR1.25430541
51STK101.24901628
52BMPR1B1.22042750
53MAPKAPK31.15414986
54MAP3K31.15145047
55TRIB31.13820009
56PAK41.12060332
57CDK121.09691609
58MAP2K21.08200018
59PBK1.06758977
60LRRK21.06096467
61BRSK10.99738126
62ZAP700.98591943
63GRK60.97965146
64CHEK20.95164880
65SIK20.93769611
66AURKA0.93130564
67RPS6KA50.93111573
68NME10.92669480
69STK40.91976975
70TAOK20.91260609
71MAP3K140.90551399
72ERN10.88984549
73CHEK10.86485358
74TLK10.84633172
75GRK10.84194374
76CSF1R0.84079913
77MKNK20.82684646
78CDK90.76720474
79IRAK10.76224845
80EIF2AK20.75794188
81ALK0.73286559
82SIK10.69986486
83JAK30.68226749
84CCNB10.68135842
85TXK0.67251146
86PLK30.67115451
87MATK0.66889355
88CDK60.65484551
89BTK0.64156472
90ILK0.63422182
91CDK20.62261152
92CSNK2A20.62169274
93MAP4K20.62093993
94TYK20.61569772
95CAMK1D0.61184856
96CSNK2A10.61047675
97ZAK0.60641166
98PRKD20.60554233
99IKBKB0.60068586
100PAK10.59822081
101HIPK20.59121722
102PDK20.57867024
103MAPKAPK50.56985952
104IRAK40.54485320
105MAP2K60.52587711
106ATM0.51232315
107IRAK20.50865626
108MAPK110.50810456
109KIT0.48331135
110IRAK30.47077073
111MELK0.45238272
112MTOR0.43870440
113CDK80.43446350
114INSRR0.43245712
115DAPK10.42361482
116PINK10.42201129
117TBK10.41742188
118PAK20.38744435
119RPS6KB10.37461650
120CHUK0.36730163
121PRKCI0.35998135
122MAPKAPK20.35900514
123AKT20.35486841
124NEK90.33863488
125MUSK0.33641514
126RPS6KL10.32719413
127RPS6KC10.32719413
128RPS6KA10.32519658
129RPS6KA60.32481013
130BRD40.32415114
131CDK10.32331282
132DYRK20.31396489
133CLK10.30182098

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.76819748
2Ribosome_Homo sapiens_hsa030103.81165901
3Mismatch repair_Homo sapiens_hsa034303.77891407
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40033857
5Proteasome_Homo sapiens_hsa030503.11348686
6RNA polymerase_Homo sapiens_hsa030202.93510752
7Base excision repair_Homo sapiens_hsa034102.91290180
8Spliceosome_Homo sapiens_hsa030402.77134671
9One carbon pool by folate_Homo sapiens_hsa006702.69567373
10RNA transport_Homo sapiens_hsa030132.60747697
11Homologous recombination_Homo sapiens_hsa034402.52304423
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49544859
13Pyrimidine metabolism_Homo sapiens_hsa002402.34785689
14Nucleotide excision repair_Homo sapiens_hsa034202.30100977
15Cell cycle_Homo sapiens_hsa041102.06990368
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60843177
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58854451
18Sulfur relay system_Homo sapiens_hsa041221.55796839
19RNA degradation_Homo sapiens_hsa030181.54626353
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.53509056
21Fanconi anemia pathway_Homo sapiens_hsa034601.53448139
22Folate biosynthesis_Homo sapiens_hsa007901.49570444
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48759969
24Biosynthesis of amino acids_Homo sapiens_hsa012301.46316211
25Non-homologous end-joining_Homo sapiens_hsa034501.42253931
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41651165
27p53 signaling pathway_Homo sapiens_hsa041151.37276850
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30926771
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30389151
30Lysine degradation_Homo sapiens_hsa003101.29708186
31Pentose phosphate pathway_Homo sapiens_hsa000301.29330092
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.27753284
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26854038
34Selenocompound metabolism_Homo sapiens_hsa004501.17790638
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.16427355
36mRNA surveillance pathway_Homo sapiens_hsa030151.14938841
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11945041
38Carbon metabolism_Homo sapiens_hsa012001.11645253
39Oxidative phosphorylation_Homo sapiens_hsa001901.10873240
40Purine metabolism_Homo sapiens_hsa002301.09108635
41Basal transcription factors_Homo sapiens_hsa030221.07368944
42Fructose and mannose metabolism_Homo sapiens_hsa000511.06362558
43Epstein-Barr virus infection_Homo sapiens_hsa051691.03680699
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.98500135
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94775776
46Antigen processing and presentation_Homo sapiens_hsa046120.94644073
47Herpes simplex infection_Homo sapiens_hsa051680.87338109
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87327349
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84081662
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81021295
51Legionellosis_Homo sapiens_hsa051340.76130932
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75391603
53Glutathione metabolism_Homo sapiens_hsa004800.72631794
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72624651
55Galactose metabolism_Homo sapiens_hsa000520.72499973
56Systemic lupus erythematosus_Homo sapiens_hsa053220.72094526
57Viral carcinogenesis_Homo sapiens_hsa052030.72017201
58Vitamin digestion and absorption_Homo sapiens_hsa049770.68486853
59Thyroid cancer_Homo sapiens_hsa052160.65948724
60Primary immunodeficiency_Homo sapiens_hsa053400.65485604
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63091225
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58617651
63Asthma_Homo sapiens_hsa053100.58171957
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55957136
65Linoleic acid metabolism_Homo sapiens_hsa005910.54927032
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54836204
67HTLV-I infection_Homo sapiens_hsa051660.54044498
68Parkinsons disease_Homo sapiens_hsa050120.51610826
69Vitamin B6 metabolism_Homo sapiens_hsa007500.50917434
70N-Glycan biosynthesis_Homo sapiens_hsa005100.50360306
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50087721
72Ether lipid metabolism_Homo sapiens_hsa005650.49923590
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49018781
74Alcoholism_Homo sapiens_hsa050340.47973756
75Small cell lung cancer_Homo sapiens_hsa052220.47793127
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47603408
77Apoptosis_Homo sapiens_hsa042100.47357858
78Pyruvate metabolism_Homo sapiens_hsa006200.46361732
79Nitrogen metabolism_Homo sapiens_hsa009100.46283913
80Phototransduction_Homo sapiens_hsa047440.45854130
81Huntingtons disease_Homo sapiens_hsa050160.45768530
82Protein export_Homo sapiens_hsa030600.45677988
83Measles_Homo sapiens_hsa051620.43940178
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42889052
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42126261
86Acute myeloid leukemia_Homo sapiens_hsa052210.41082917
87Shigellosis_Homo sapiens_hsa051310.40994322
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40719363
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.40029636
90Arginine and proline metabolism_Homo sapiens_hsa003300.39920667
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39706899
92Metabolic pathways_Homo sapiens_hsa011000.38311459
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35622151
94Bladder cancer_Homo sapiens_hsa052190.35342572
95ABC transporters_Homo sapiens_hsa020100.34326126
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.34269765
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32528853
98Allograft rejection_Homo sapiens_hsa053300.32509666
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32099430
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31630397
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30709157
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30381633
103Chronic myeloid leukemia_Homo sapiens_hsa052200.29602826
104Other glycan degradation_Homo sapiens_hsa005110.27094800
105Notch signaling pathway_Homo sapiens_hsa043300.26542156
106Oocyte meiosis_Homo sapiens_hsa041140.26514262
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25075436
108Autoimmune thyroid disease_Homo sapiens_hsa053200.24820439
109Influenza A_Homo sapiens_hsa051640.24216945
110HIF-1 signaling pathway_Homo sapiens_hsa040660.24146812
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24068922
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23082490
113Tryptophan metabolism_Homo sapiens_hsa003800.22009087
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.21985584
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20876114
116MicroRNAs in cancer_Homo sapiens_hsa052060.20307035
117Propanoate metabolism_Homo sapiens_hsa006400.20166078
118Graft-versus-host disease_Homo sapiens_hsa053320.19952409
119Hepatitis B_Homo sapiens_hsa051610.19083380
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.18714630
121Butanoate metabolism_Homo sapiens_hsa006500.18015530
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17878368
123Caffeine metabolism_Homo sapiens_hsa002320.17183599
124Alzheimers disease_Homo sapiens_hsa050100.16797837
125Fatty acid degradation_Homo sapiens_hsa000710.16283489
126Glycerolipid metabolism_Homo sapiens_hsa005610.16242316
127Hematopoietic cell lineage_Homo sapiens_hsa046400.15915873
128Sulfur metabolism_Homo sapiens_hsa009200.14792415
129B cell receptor signaling pathway_Homo sapiens_hsa046620.13590753
130Type I diabetes mellitus_Homo sapiens_hsa049400.13513049
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13502693
132Sphingolipid metabolism_Homo sapiens_hsa006000.13201909
133Leishmaniasis_Homo sapiens_hsa051400.13004754
134mTOR signaling pathway_Homo sapiens_hsa041500.12955735
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12343969
136beta-Alanine metabolism_Homo sapiens_hsa004100.12107231

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