PUS7L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.65603708
2monoubiquitinated protein deubiquitination (GO:0035520)5.09440790
3indolalkylamine metabolic process (GO:0006586)4.71497507
4maturation of SSU-rRNA (GO:0030490)4.58866056
5neural tube formation (GO:0001841)4.55242226
6DNA replication initiation (GO:0006270)4.48662280
7viral transcription (GO:0019083)4.35145235
8regulation of establishment of cell polarity (GO:2000114)4.33435419
9DNA strand elongation involved in DNA replication (GO:0006271)4.31947718
10telomere maintenance via semi-conservative replication (GO:0032201)4.31679446
11ribosomal small subunit biogenesis (GO:0042274)4.31244392
12translational termination (GO:0006415)4.28066162
13tryptophan catabolic process (GO:0006569)4.26961756
14indole-containing compound catabolic process (GO:0042436)4.26961756
15indolalkylamine catabolic process (GO:0046218)4.26961756
16DNA deamination (GO:0045006)4.25458993
17DNA strand elongation (GO:0022616)4.25383456
18DNA unwinding involved in DNA replication (GO:0006268)4.13290265
19formation of translation preinitiation complex (GO:0001731)3.96326238
20nucleobase biosynthetic process (GO:0046112)3.92434232
21IMP biosynthetic process (GO:0006188)3.91702640
22translational elongation (GO:0006414)3.90220239
23signal peptide processing (GO:0006465)3.89307024
24protein K48-linked deubiquitination (GO:0071108)3.88125242
25kynurenine metabolic process (GO:0070189)3.87889947
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87815489
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.86221004
28tryptophan metabolic process (GO:0006568)3.86164351
29IMP metabolic process (GO:0046040)3.79968059
30* pseudouridine synthesis (GO:0001522)3.79610947
31telomere maintenance via recombination (GO:0000722)3.78459996
32regulation of hippo signaling (GO:0035330)3.78079551
33cotranslational protein targeting to membrane (GO:0006613)3.77998134
34protein targeting to ER (GO:0045047)3.77304562
35protein K11-linked deubiquitination (GO:0035871)3.76868171
36detection of light stimulus involved in sensory perception (GO:0050962)3.73844762
37detection of light stimulus involved in visual perception (GO:0050908)3.73844762
38translational initiation (GO:0006413)3.69021505
39DNA double-strand break processing (GO:0000729)3.66011581
40regulation of establishment or maintenance of cell polarity (GO:0032878)3.65774520
41lipid translocation (GO:0034204)3.65648458
42phospholipid translocation (GO:0045332)3.65648458
43protein K63-linked deubiquitination (GO:0070536)3.59846725
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.59685541
45ribonucleoprotein complex biogenesis (GO:0022613)3.59363243
46protein localization to endoplasmic reticulum (GO:0070972)3.58213794
47folic acid-containing compound biosynthetic process (GO:0009396)3.57936865
48rRNA catabolic process (GO:0016075)3.57006828
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.56053963
50telomere maintenance via telomere lengthening (GO:0010833)3.50673112
51mitotic recombination (GO:0006312)3.48142145
52purine nucleobase biosynthetic process (GO:0009113)3.43686036
53establishment of protein localization to Golgi (GO:0072600)3.43577873
54regulation of sarcomere organization (GO:0060297)3.43416316
55ribosome biogenesis (GO:0042254)3.42378695
56rRNA processing (GO:0006364)3.41496026
57ribosomal large subunit biogenesis (GO:0042273)3.41300357
58histone H3-K9 methylation (GO:0051567)3.37090022
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.36444128
60cellular protein complex disassembly (GO:0043624)3.35662219
61reflex (GO:0060004)3.35030388
62interkinetic nuclear migration (GO:0022027)3.30782099
63rRNA metabolic process (GO:0016072)3.29494484
64ribosome assembly (GO:0042255)3.29037522
65behavioral response to ethanol (GO:0048149)3.27851003
66L-fucose catabolic process (GO:0042355)3.26526203
67fucose catabolic process (GO:0019317)3.26526203
68L-fucose metabolic process (GO:0042354)3.26526203
69prenylation (GO:0097354)3.24788604
70protein prenylation (GO:0018342)3.24788604
71viral life cycle (GO:0019058)3.22135831
72mitotic nuclear envelope disassembly (GO:0007077)3.21002554
73replication fork processing (GO:0031297)3.20033809
74regulation of gene silencing by RNA (GO:0060966)3.19502421
75regulation of posttranscriptional gene silencing (GO:0060147)3.19502421
76regulation of gene silencing by miRNA (GO:0060964)3.19502421
77negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17721786
78indole-containing compound metabolic process (GO:0042430)3.16406398
79DNA replication checkpoint (GO:0000076)3.16351614
80UDP-N-acetylglucosamine metabolic process (GO:0006047)3.16102780
81CENP-A containing nucleosome assembly (GO:0034080)3.11205013
82positive regulation of developmental pigmentation (GO:0048087)3.08970854
83ncRNA 3-end processing (GO:0043628)3.06394598
84double-strand break repair via homologous recombination (GO:0000724)3.03480077
85negative regulation of translation, ncRNA-mediated (GO:0040033)3.02558895
86regulation of translation, ncRNA-mediated (GO:0045974)3.02558895
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.02558895
88regulation of pigment cell differentiation (GO:0050932)2.99904952
89chromatin remodeling at centromere (GO:0031055)2.99472896
90recombinational repair (GO:0000725)2.98843717
91protein complex disassembly (GO:0043241)2.98701968
92nuclear-transcribed mRNA catabolic process (GO:0000956)2.98417499
93protein localization to kinetochore (GO:0034501)2.98189572
94serotonin metabolic process (GO:0042428)2.97564652
95cilium or flagellum-dependent cell motility (GO:0001539)2.96894938
96microtubule anchoring (GO:0034453)2.96458624
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.93155026
98regulation of DNA endoreduplication (GO:0032875)2.92970692
99benzene-containing compound metabolic process (GO:0042537)2.92598871
100cytoplasmic mRNA processing body assembly (GO:0033962)2.92581263
101positive regulation of B cell differentiation (GO:0045579)2.92378619
102cellular response to sterol (GO:0036315)2.89970524
103centriole replication (GO:0007099)2.89641820
104behavioral response to nicotine (GO:0035095)2.89587930
105membrane disassembly (GO:0030397)2.89337052
106nuclear envelope disassembly (GO:0051081)2.89337052
107snRNA processing (GO:0016180)2.88449378
108translation (GO:0006412)2.87614567
109cell morphogenesis involved in neuron differentiation (GO:0048667)2.87104701
110spliceosomal snRNP assembly (GO:0000387)2.85818398
111rRNA modification (GO:0000154)2.85671331
112mRNA catabolic process (GO:0006402)2.84637128
113negative regulation of smooth muscle cell differentiation (GO:0051151)2.84292859
114photoreceptor cell maintenance (GO:0045494)2.83698928
115nuclear pore complex assembly (GO:0051292)2.82917804
116macromolecular complex disassembly (GO:0032984)2.82641383
117alternative mRNA splicing, via spliceosome (GO:0000380)2.82275659
118DNA replication-independent nucleosome assembly (GO:0006336)2.81129304
119DNA replication-independent nucleosome organization (GO:0034724)2.81129304
120regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.79455428
121RNA catabolic process (GO:0006401)2.79399687
122snRNA transcription (GO:0009301)2.79326165
123antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79013657
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.79013657
125primary amino compound metabolic process (GO:1901160)2.78072310
126cellular ketone body metabolic process (GO:0046950)2.77677021
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76746444
128snRNA metabolic process (GO:0016073)2.75318740
129replicative senescence (GO:0090399)2.74500204
130negative regulation of RNA splicing (GO:0033119)2.73003173
131* ncRNA processing (GO:0034470)2.72426766
132negative regulation of phagocytosis (GO:0050765)2.72266980
133somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.71539623
134somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.71539623
135isotype switching (GO:0045190)2.71539623
136peristalsis (GO:0030432)2.71502443
137gene silencing by RNA (GO:0031047)2.71391798
138nuclear pore organization (GO:0006999)2.70524078
139regulation of rhodopsin mediated signaling pathway (GO:0022400)2.69589277
140cellular component biogenesis (GO:0044085)2.68413952
141establishment of integrated proviral latency (GO:0075713)2.67162858
142somatic hypermutation of immunoglobulin genes (GO:0016446)2.67145552
143somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67145552
144ncRNA catabolic process (GO:0034661)2.66899674
145nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66633624
146telomere maintenance (GO:0000723)2.66150164
147regulation of centriole replication (GO:0046599)2.65723298
148telomere organization (GO:0032200)2.65662087
149mitotic chromosome condensation (GO:0007076)2.65605592
150embryonic epithelial tube formation (GO:0001838)2.65456713
151mRNA splicing, via spliceosome (GO:0000398)2.65120090
152RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.65120090
153rhodopsin mediated signaling pathway (GO:0016056)2.65026024
154reciprocal meiotic recombination (GO:0007131)2.64643101
155reciprocal DNA recombination (GO:0035825)2.64643101
156Arp2/3 complex-mediated actin nucleation (GO:0034314)2.64373301
157phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.64309359
158negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.63864178
159sulfation (GO:0051923)2.63713387
160mitotic sister chromatid cohesion (GO:0007064)2.62631514
161RNA splicing, via transesterification reactions (GO:0000375)2.62540148
162meiotic chromosome segregation (GO:0045132)2.61831886
163detection of mechanical stimulus involved in sensory perception (GO:0050974)2.60138637
164tachykinin receptor signaling pathway (GO:0007217)2.59929468
165DNA demethylation (GO:0080111)2.59633589
166histone mRNA metabolic process (GO:0008334)2.59452097
167termination of RNA polymerase II transcription (GO:0006369)2.59239157
168positive regulation of gamma-delta T cell activation (GO:0046645)2.59177851
169kinetochore organization (GO:0051383)2.58473673
170RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58294991
171DNA duplex unwinding (GO:0032508)2.58198155
172thyroid hormone metabolic process (GO:0042403)2.58167806
173sensory perception of smell (GO:0007608)2.58114580
174* ncRNA metabolic process (GO:0034660)2.58094314
175rRNA methylation (GO:0031167)2.57685753
176gamma-aminobutyric acid transport (GO:0015812)2.57033928
177histone H3-K9 modification (GO:0061647)2.56730074
178termination of RNA polymerase III transcription (GO:0006386)2.56508546
179transcription elongation from RNA polymerase III promoter (GO:0006385)2.56508546
180mitotic metaphase plate congression (GO:0007080)2.56429046
181sex differentiation (GO:0007548)2.55647904
182flavonoid metabolic process (GO:0009812)2.55325911
183microtubule organizing center organization (GO:0031023)2.54649388
184DNA replication-dependent nucleosome assembly (GO:0006335)2.54603956
185DNA replication-dependent nucleosome organization (GO:0034723)2.54603956
186cilium morphogenesis (GO:0060271)2.54571192
187DNA geometric change (GO:0032392)2.53679781
188sister chromatid cohesion (GO:0007062)2.52662611
189tRNA aminoacylation for protein translation (GO:0006418)2.52432559
190ketone body metabolic process (GO:1902224)2.51511563
191maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.50892674
192viral mRNA export from host cell nucleus (GO:0046784)2.50830902
193protein targeting to vacuole (GO:0006623)2.48674601
194protein targeting to lysosome (GO:0006622)2.48674601
195establishment of protein localization to vacuole (GO:0072666)2.48674601
196peptidyl-lysine trimethylation (GO:0018023)2.48573297
197epithelial tube formation (GO:0072175)2.48319627
198protein targeting to Golgi (GO:0000042)2.46613846
199righting reflex (GO:0060013)2.44676645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.93557462
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.08256003
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.03213709
4GBX2_23144817_ChIP-Seq_PC3_Human3.33204150
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.08280571
6IGF1R_20145208_ChIP-Seq_DFB_Human3.05035569
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.91445468
8* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.90531486
9VDR_22108803_ChIP-Seq_LS180_Human2.89480732
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.88002555
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.77046501
12ZNF274_21170338_ChIP-Seq_K562_Hela2.75613001
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.70615963
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65710792
15TAF15_26573619_Chip-Seq_HEK293_Human2.65634053
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62472081
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60485273
18FUS_26573619_Chip-Seq_HEK293_Human2.59774802
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.58029748
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.57712709
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57534956
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54994490
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54797014
24EWS_26573619_Chip-Seq_HEK293_Human2.53969041
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53904015
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51308219
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.48218010
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45923760
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.45704633
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.43273984
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43036162
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42349817
33MYC_22102868_ChIP-Seq_BL_Human2.40608831
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35026118
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33514988
36CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29289888
37* VDR_23849224_ChIP-Seq_CD4+_Human2.28391594
38FLI1_27457419_Chip-Seq_LIVER_Mouse2.26066498
39P300_19829295_ChIP-Seq_ESCs_Human2.23747695
40XRN2_22483619_ChIP-Seq_HELA_Human2.17159629
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.15417699
42FOXP3_21729870_ChIP-Seq_TREG_Human2.14730773
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.12762326
44ER_23166858_ChIP-Seq_MCF-7_Human2.10144480
45* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06730105
46NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06656021
47BP1_19119308_ChIP-ChIP_Hs578T_Human2.06146184
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04714697
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93779002
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93411212
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92319340
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89487804
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.89435194
54STAT3_23295773_ChIP-Seq_U87_Human1.88911562
55ELK1_19687146_ChIP-ChIP_HELA_Human1.87424712
56CIITA_25753668_ChIP-Seq_RAJI_Human1.87091408
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.86432241
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85343741
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84367173
60VDR_21846776_ChIP-Seq_THP-1_Human1.84336968
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.82882525
62* NOTCH1_21737748_ChIP-Seq_TLL_Human1.81730658
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80881659
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79973551
65DCP1A_22483619_ChIP-Seq_HELA_Human1.79665459
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78455626
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76892857
68SMAD4_21799915_ChIP-Seq_A2780_Human1.76838443
69AR_21909140_ChIP-Seq_LNCAP_Human1.76128542
70AR_21572438_ChIP-Seq_LNCaP_Human1.75398455
71GABP_19822575_ChIP-Seq_HepG2_Human1.74229770
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72934795
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72547690
74* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72094493
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70134875
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70062182
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69586480
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68996916
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68490242
80SPI1_23547873_ChIP-Seq_NB4_Human1.66584662
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64426368
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63094971
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62963533
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.61912746
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61473220
86TCF4_23295773_ChIP-Seq_U87_Human1.60732455
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.59741174
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58559387
89CBP_20019798_ChIP-Seq_JUKART_Human1.58262376
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58262376
91TTF2_22483619_ChIP-Seq_HELA_Human1.55859783
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54268571
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53345201
94BCAT_22108803_ChIP-Seq_LS180_Human1.52125228
95* SCL_19346495_ChIP-Seq_HPC-7_Human1.51444465
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50972172
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49490693
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49476885
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47686764
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45682314
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45274863
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44491588
103FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43915869
104RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43380662
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42958584
106AR_25329375_ChIP-Seq_VCAP_Human1.42894154
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42536300
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41797686
109EZH2_22144423_ChIP-Seq_EOC_Human1.39717606
110SRF_21415370_ChIP-Seq_HL-1_Mouse1.39368700
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39084531
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.38701291
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38595586
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.37806353
115IRF8_22096565_ChIP-ChIP_GC-B_Human1.36709523
116STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36644174
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.36609819
118TCF4_22108803_ChIP-Seq_LS180_Human1.36219434
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35606144
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35028602
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34862106
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34454818
123MYB_26560356_Chip-Seq_TH2_Human1.34246280
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34230310
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34230310
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34190003
127FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34131609
128CDX2_22108803_ChIP-Seq_LS180_Human1.32403257
129PRDM14_20953172_ChIP-Seq_ESCs_Human1.31664501
130RUNX2_22187159_ChIP-Seq_PCA_Human1.31490350
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30327467
132IRF1_19129219_ChIP-ChIP_H3396_Human1.28039807
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.27946230
134KDM5A_27292631_Chip-Seq_BREAST_Human1.27276021
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.24373107
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23236701
137IRF8_21731497_ChIP-ChIP_J774_Mouse1.23168896
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22066376
139KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21880095
140VDR_24763502_ChIP-Seq_THP-1_Human1.21645165
141CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20931406
142SMAD4_21741376_ChIP-Seq_EPCs_Human1.20852362
143P53_22387025_ChIP-Seq_ESCs_Mouse1.20181317
144OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19190746
145TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18861897
146RUNX1_22412390_ChIP-Seq_EML_Mouse1.17389560
147NANOG_19829295_ChIP-Seq_ESCs_Human1.17250865
148SOX2_19829295_ChIP-Seq_ESCs_Human1.17250865
149TFEB_21752829_ChIP-Seq_HELA_Human1.14392095
150MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13854362
151YY1_21170310_ChIP-Seq_MESCs_Mouse1.13563478
152* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13519078
153STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12534232
154GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11854833
155MYB_26560356_Chip-Seq_TH1_Human1.11120318
156GATA1_22025678_ChIP-Seq_K562_Human1.10342726
157SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10028240
158P300_18555785_Chip-Seq_ESCs_Mouse1.09700735
159FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09133829
160SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08647650
161MAF_26560356_Chip-Seq_TH1_Human1.08093788
162CMYC_18555785_Chip-Seq_ESCs_Mouse1.08023398
163STAT3_18555785_Chip-Seq_ESCs_Mouse1.06782332
164ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06324121
165RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06268890
166BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06187269
167PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06052779
168RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05994186
169UTX_26944678_Chip-Seq_JUKART_Human1.05861080
170CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05042821
171MYC_18940864_ChIP-ChIP_HL60_Human1.04816484
172RXR_22108803_ChIP-Seq_LS180_Human1.04498894
173TP53_22573176_ChIP-Seq_HFKS_Human1.04350145
174TP53_16413492_ChIP-PET_HCT116_Human1.04200630
175SMAD_19615063_ChIP-ChIP_OVARY_Human1.04170152
176ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04068549
177RNF2_27304074_Chip-Seq_NSC_Mouse1.02902061
178* TBL1_22424771_ChIP-Seq_293T_Human1.02377058
179CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02162315
180NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01989991
181NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01989991
182ARNT_22903824_ChIP-Seq_MCF-7_Human1.01792365
183CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00985925
184CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00803657
185GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98353999
186KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96876170
187* MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96330493
188FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93387875
189NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91320014
190NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91059092
191DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90803786
192NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89778260
193E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89731921
194PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88190465

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.10203690
2MP0002396_abnormal_hematopoietic_system4.17431076
3MP0003693_abnormal_embryo_hatching3.88862311
4MP0008057_abnormal_DNA_replication3.71939512
5MP0010094_abnormal_chromosome_stability3.58302377
6MP0003195_calcinosis3.08948438
7MP0004957_abnormal_blastocyst_morpholog3.04389297
8MP0003111_abnormal_nucleus_morphology2.97027236
9MP0003077_abnormal_cell_cycle2.92566878
10MP0003763_abnormal_thymus_physiology2.80535083
11MP0003806_abnormal_nucleotide_metabolis2.72449473
12MP0009046_muscle_twitch2.59990961
13MP0001835_abnormal_antigen_presentation2.51292183
14MP0009333_abnormal_splenocyte_physiolog2.49953250
15MP0008058_abnormal_DNA_repair2.39943080
16MP0010307_abnormal_tumor_latency2.29270465
17MP0008007_abnormal_cellular_replicative2.27835654
18MP0005551_abnormal_eye_electrophysiolog2.27045488
19MP0000490_abnormal_crypts_of2.17215136
20MP0004808_abnormal_hematopoietic_stem2.17100739
21MP0002398_abnormal_bone_marrow2.14598555
22MP0006072_abnormal_retinal_apoptosis2.14498981
23MP0005671_abnormal_response_to2.13536027
24MP0003950_abnormal_plasma_membrane2.10833320
25MP0009697_abnormal_copulation2.10505354
26MP0001545_abnormal_hematopoietic_system2.06307868
27MP0005397_hematopoietic_system_phenotyp2.06307868
28MP0001873_stomach_inflammation2.05465467
29MP0001800_abnormal_humoral_immune1.97406188
30MP0000465_gastrointestinal_hemorrhage1.95373046
31MP0000689_abnormal_spleen_morphology1.85758270
32MP0001501_abnormal_sleep_pattern1.84753492
33MP0005075_abnormal_melanosome_morpholog1.84126339
34MP0000685_abnormal_immune_system1.84031423
35MP0005253_abnormal_eye_physiology1.83124225
36MP0000427_abnormal_hair_cycle1.82435672
37MP0002722_abnormal_immune_system1.82110765
38MP0009785_altered_susceptibility_to1.81556933
39MP0000703_abnormal_thymus_morphology1.81499964
40MP0002420_abnormal_adaptive_immunity1.76433223
41MP0003436_decreased_susceptibility_to1.74973653
42MP0006054_spinal_hemorrhage1.74101340
43MP0003252_abnormal_bile_duct1.72654450
44MP0000716_abnormal_immune_system1.71500924
45MP0001819_abnormal_immune_cell1.70952582
46MP0001968_abnormal_touch/_nociception1.69502701
47MP0002452_abnormal_antigen_presenting1.67562345
48MP0008932_abnormal_embryonic_tissue1.67400424
49MP0002429_abnormal_blood_cell1.66545428
50MP0002723_abnormal_immune_serum1.66427047
51MP0005646_abnormal_pituitary_gland1.65012031
52MP0005000_abnormal_immune_tolerance1.64328360
53MP0002019_abnormal_tumor_incidence1.62224717
54MP0003718_maternal_effect1.60568648
55MP0000350_abnormal_cell_proliferation1.59240097
56MP0010352_gastrointestinal_tract_polyps1.58132762
57MP0005025_abnormal_response_to1.54536942
58MP0004043_abnormal_pH_regulation1.54289889
59MP0002102_abnormal_ear_morphology1.54277587
60MP0002405_respiratory_system_inflammati1.52769999
61MP0000631_abnormal_neuroendocrine_gland1.51802952
62MP0002009_preneoplasia1.50465481
63MP0003890_abnormal_embryonic-extraembry1.50420217
64MP0005171_absent_coat_pigmentation1.49869286
65MP0000383_abnormal_hair_follicle1.49084693
66MP0003136_yellow_coat_color1.48320154
67MP0001730_embryonic_growth_arrest1.46909591
68MP0002736_abnormal_nociception_after1.46118747
69MP0010155_abnormal_intestine_physiology1.45272306
70MP0004147_increased_porphyrin_level1.43730969
71MP0000372_irregular_coat_pigmentation1.43283527
72MP0002148_abnormal_hypersensitivity_rea1.41091511
73MP0005464_abnormal_platelet_physiology1.40991391
74MP0001790_abnormal_immune_system1.40787854
75MP0005387_immune_system_phenotype1.40787854
76MP0000858_altered_metastatic_potential1.39719928
77MP0002419_abnormal_innate_immunity1.38530571
78MP0003724_increased_susceptibility_to1.34798481
79MP0000015_abnormal_ear_pigmentation1.34525835
80MP0003646_muscle_fatigue1.34344401
81MP0003045_fibrosis1.33549194
82MP0005645_abnormal_hypothalamus_physiol1.33526754
83MP0005187_abnormal_penis_morphology1.33179747
84MP0001853_heart_inflammation1.32902723
85MP0005174_abnormal_tail_pigmentation1.32659410
86MP0008872_abnormal_physiological_respon1.32640762
87MP0003303_peritoneal_inflammation1.32183954
88MP0002938_white_spotting1.30106823
89MP0000313_abnormal_cell_death1.29321722
90MP0002837_dystrophic_cardiac_calcinosis1.27121293
91MP0009379_abnormal_foot_pigmentation1.25064680
92MP0003786_premature_aging1.24658346
93MP0001485_abnormal_pinna_reflex1.22008677
94MP0009745_abnormal_behavioral_response1.21986334
95MP0003656_abnormal_erythrocyte_physiolo1.21368178
96MP0000371_diluted_coat_color1.20213633
97MP0003937_abnormal_limbs/digits/tail_de1.19976651
98MP0002160_abnormal_reproductive_system1.18791088
99MP0003866_abnormal_defecation1.17898852
100MP0002138_abnormal_hepatobiliary_system1.15980776
101MP0006276_abnormal_autonomic_nervous1.14717926
102MP0003787_abnormal_imprinting1.14385228
103MP0002166_altered_tumor_susceptibility1.13101054
104MP0003943_abnormal_hepatobiliary_system1.12758108
105MP0005395_other_phenotype1.11118303
106MP0008877_abnormal_DNA_methylation1.10417155
107MP0002928_abnormal_bile_duct1.08786110
108MP0001845_abnormal_inflammatory_respons1.05809988
109MP0002933_joint_inflammation1.05515713
110MP0002272_abnormal_nervous_system1.05037750
111MP0002080_prenatal_lethality1.04671023
112MP0001697_abnormal_embryo_size1.03066353
113MP0005386_behavior/neurological_phenoty1.02963701
114MP0004924_abnormal_behavior1.02963701
115MP0002095_abnormal_skin_pigmentation1.02875589
116MP0002067_abnormal_sensory_capabilities1.00392084
117MP0001486_abnormal_startle_reflex0.99858984
118MP0010678_abnormal_skin_adnexa0.99715755
119MP0002168_other_aberrant_phenotype0.97446329
120MP0004134_abnormal_chest_morphology0.96892531
121MP0005389_reproductive_system_phenotype0.96600949
122MP0002132_abnormal_respiratory_system0.95552872
123MP0002735_abnormal_chemical_nociception0.95339298
124MP0000647_abnormal_sebaceous_gland0.95246904
125MP0004142_abnormal_muscle_tone0.95096044
126MP0003123_paternal_imprinting0.94679006
127MP0004145_abnormal_muscle_electrophysio0.94184473
128MP0003186_abnormal_redox_activity0.93606853
129MP0008961_abnormal_basal_metabolism0.91920328
130MP0003984_embryonic_growth_retardation0.90395885
131MP0001672_abnormal_embryogenesis/_devel0.89914028
132MP0005380_embryogenesis_phenotype0.89914028
133MP0003698_abnormal_male_reproductive0.88028904
134MP0002088_abnormal_embryonic_growth/wei0.87982904
135MP0001929_abnormal_gametogenesis0.87865585
136MP0002234_abnormal_pharynx_morphology0.87733701
137MP0004215_abnormal_myocardial_fiber0.86958055
138MP0003221_abnormal_cardiomyocyte_apopto0.86456615
139MP0002572_abnormal_emotion/affect_behav0.85839725
140MP0009278_abnormal_bone_marrow0.84478077
141MP0005085_abnormal_gallbladder_physiolo0.82442517
142MP0000477_abnormal_intestine_morphology0.81544744
143MP0002229_neurodegeneration0.81240427
144MP0003448_altered_tumor_morphology0.81086838
145MP0002006_tumorigenesis0.81027596
146MP0002638_abnormal_pupillary_reflex0.80887969
147MP0002557_abnormal_social/conspecific_i0.79556258
148MP0003567_abnormal_fetal_cardiomyocyte0.79129127
149MP0000358_abnormal_cell_content/0.78992058
150MP0000653_abnormal_sex_gland0.78716958
151MP0004197_abnormal_fetal_growth/weight/0.77582867
152MP0008469_abnormal_protein_level0.76257055
153MP0003632_abnormal_nervous_system0.75660022
154MP0001984_abnormal_olfaction0.75349057
155MP0002086_abnormal_extraembryonic_tissu0.75153642
156MP0005310_abnormal_salivary_gland0.75148987
157MP0004742_abnormal_vestibular_system0.74795822
158MP0008873_increased_physiological_sensi0.73666118
159MP0002064_seizures0.73168993
160MP0005266_abnormal_metabolism0.72548852
161MP0001915_intracranial_hemorrhage0.72480324
162MP0005195_abnormal_posterior_eye0.72283483
163MP0002876_abnormal_thyroid_physiology0.71580948
164MP0002693_abnormal_pancreas_physiology0.71405013
165MP0001324_abnormal_eye_pigmentation0.71167644
166MP0005391_vision/eye_phenotype0.70558099
167MP0010386_abnormal_urinary_bladder0.70438566
168MP0002210_abnormal_sex_determination0.70414585
169MP0001533_abnormal_skeleton_physiology0.69498323
170MP0005023_abnormal_wound_healing0.68382413
171MP0006036_abnormal_mitochondrial_physio0.67835729
172MP0005410_abnormal_fertilization0.67478053
173MP0003633_abnormal_nervous_system0.65409695
174MP0008995_early_reproductive_senescence0.65233418
175MP0005621_abnormal_cell_physiology0.64744549
176MP0001145_abnormal_male_reproductive0.64647115
177MP0003300_gastrointestinal_ulcer0.64619319
178MP0004947_skin_inflammation0.64232475
179MP0000230_abnormal_systemic_arterial0.63452353
180MP0002109_abnormal_limb_morphology0.63316617
181MP0003631_nervous_system_phenotype0.63279104
182MP0003880_abnormal_central_pattern0.62564666
183MP0005384_cellular_phenotype0.62202957
184MP0001663_abnormal_digestive_system0.61307508
185MP0002085_abnormal_embryonic_tissue0.59792132
186MP0003172_abnormal_lysosome_physiology0.59053527
187MP0000598_abnormal_liver_morphology0.57095904
188MP0001764_abnormal_homeostasis0.56852234

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.29546786
2Thrombocytosis (HP:0001894)4.56290521
3Abnormality of cells of the erythroid lineage (HP:0012130)4.55963751
4Abnormal number of erythroid precursors (HP:0012131)4.52642608
5Pancreatic cysts (HP:0001737)4.50852330
6Reticulocytopenia (HP:0001896)4.19425152
7True hermaphroditism (HP:0010459)4.04556131
8Pancreatic fibrosis (HP:0100732)4.04234332
9Congenital stationary night blindness (HP:0007642)4.00520844
10Birth length less than 3rd percentile (HP:0003561)3.80957132
11Gaze-evoked nystagmus (HP:0000640)3.74354996
12Genetic anticipation (HP:0003743)3.64278441
13Poikiloderma (HP:0001029)3.53558861
14Panhypogammaglobulinemia (HP:0003139)3.51670931
15Petechiae (HP:0000967)3.51053710
16Molar tooth sign on MRI (HP:0002419)3.47963622
17Abnormality of midbrain morphology (HP:0002418)3.47963622
18Recurrent viral infections (HP:0004429)3.39615607
19Type 2 muscle fiber atrophy (HP:0003554)3.34493561
20Elevated erythrocyte sedimentation rate (HP:0003565)3.29586627
21Nephronophthisis (HP:0000090)3.26898067
22Abnormality of the renal cortex (HP:0011035)3.26741196
23IgM deficiency (HP:0002850)3.20707311
24Muscle fiber atrophy (HP:0100295)3.09831397
25Aplasia/Hypoplasia of the uvula (HP:0010293)3.09596543
26Abnormality of T cell physiology (HP:0011840)3.09416143
27Oral leukoplakia (HP:0002745)3.08878638
28Abnormal biliary tract physiology (HP:0012439)3.06869750
29Bile duct proliferation (HP:0001408)3.06869750
30Selective tooth agenesis (HP:0001592)3.02216923
31Volvulus (HP:0002580)3.00670058
32Hyperventilation (HP:0002883)2.99428381
33Renal cortical cysts (HP:0000803)2.98102925
34Abnormality of the renal medulla (HP:0100957)2.92765686
35Abnormality of the renal collecting system (HP:0004742)2.90715809
36Febrile seizures (HP:0002373)2.89371735
37Duplicated collecting system (HP:0000081)2.87875985
38Chronic otitis media (HP:0000389)2.86790671
39Macrocytic anemia (HP:0001972)2.86198749
40Progressive cerebellar ataxia (HP:0002073)2.84399719
41Clubbing of toes (HP:0100760)2.82628859
42Amaurosis fugax (HP:0100576)2.82500775
43Fair hair (HP:0002286)2.81506769
44Abnormality of T cells (HP:0002843)2.80646164
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.80030323
46Abnormality of the ileum (HP:0001549)2.73509798
47Premature graying of hair (HP:0002216)2.72278709
48Pustule (HP:0200039)2.71445919
49Pallor (HP:0000980)2.69518841
50Basal cell carcinoma (HP:0002671)2.68052227
51Lymphoma (HP:0002665)2.67869358
52Myositis (HP:0100614)2.67140213
53Reduced antithrombin III activity (HP:0001976)2.66638180
54Attenuation of retinal blood vessels (HP:0007843)2.65641482
55Cystic liver disease (HP:0006706)2.63188085
56Hypothermia (HP:0002045)2.61658848
57Meckel diverticulum (HP:0002245)2.60262386
5811 pairs of ribs (HP:0000878)2.56942558
59Gastrointestinal inflammation (HP:0004386)2.56595808
60Myelodysplasia (HP:0002863)2.56078081
61Inflammation of the large intestine (HP:0002037)2.54408859
62Chromsome breakage (HP:0040012)2.52323445
63Generalized hypopigmentation of hair (HP:0011358)2.51963569
64Pancytopenia (HP:0001876)2.51734901
65Intestinal atresia (HP:0011100)2.51069865
66Medial flaring of the eyebrow (HP:0010747)2.50068707
67Abnormality of the prostate (HP:0008775)2.47894768
68Furrowed tongue (HP:0000221)2.47800245
69Protruding tongue (HP:0010808)2.46628965
70Chronic hepatic failure (HP:0100626)2.43645918
71Prolonged bleeding time (HP:0003010)2.43467115
72Agammaglobulinemia (HP:0004432)2.40612206
73Aplasia/Hypoplasia of the tongue (HP:0010295)2.38665768
74Aplasia/Hypoplasia of the tibia (HP:0005772)2.37643153
75Multiple enchondromatosis (HP:0005701)2.37078988
76Colon cancer (HP:0003003)2.35558747
77Type I transferrin isoform profile (HP:0003642)2.34942705
78T lymphocytopenia (HP:0005403)2.33700514
79Central scotoma (HP:0000603)2.33439611
80Entropion (HP:0000621)2.30197507
81Abolished electroretinogram (ERG) (HP:0000550)2.29225943
82Meningitis (HP:0001287)2.29027995
83Rough bone trabeculation (HP:0100670)2.28571162
84Impaired smooth pursuit (HP:0007772)2.28304001
85Progressive inability to walk (HP:0002505)2.27721439
86Type II lissencephaly (HP:0007260)2.26872681
87Abnormality of chromosome stability (HP:0003220)2.26472737
88Recurrent fungal infections (HP:0002841)2.22665725
89Sloping forehead (HP:0000340)2.21792295
90Recurrent abscess formation (HP:0002722)2.19382289
91Agnosia (HP:0010524)2.18135824
92Inability to walk (HP:0002540)2.17664054
93Abnormality of the preputium (HP:0100587)2.16782754
94Absent radius (HP:0003974)2.14885682
95Abnormality of T cell number (HP:0011839)2.14878450
96Encephalitis (HP:0002383)2.14615577
97Recurrent bronchitis (HP:0002837)2.13217410
98Exertional dyspnea (HP:0002875)2.12919346
99Abnormal platelet volume (HP:0011876)2.12159739
100Cerebellar dysplasia (HP:0007033)2.12099985
101Bony spicule pigmentary retinopathy (HP:0007737)2.11963963
102Hypoplastic labia majora (HP:0000059)2.11463912
103Bifid tongue (HP:0010297)2.10788419
104Sclerocornea (HP:0000647)2.10769752
105Absent forearm bone (HP:0003953)2.09316532
106Aplasia involving forearm bones (HP:0009822)2.09316532
107Cutaneous melanoma (HP:0012056)2.08124246
108Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07654807
109Squamous cell carcinoma (HP:0002860)2.04745210
110Bone marrow hypocellularity (HP:0005528)2.04670944
111Epistaxis (HP:0000421)2.04600714
112Congenital hepatic fibrosis (HP:0002612)2.02865812
113Ectopic kidney (HP:0000086)2.01760665
114Cellulitis (HP:0100658)2.00721933
115Abnormality of the heme biosynthetic pathway (HP:0010472)1.99633306
116Male pseudohermaphroditism (HP:0000037)1.99147190
117Increased serum lactate (HP:0002151)1.98468534
118IgG deficiency (HP:0004315)1.98325427
119Tubular atrophy (HP:0000092)1.97908860
120Pulmonary fibrosis (HP:0002206)1.97898739
121Acute myeloid leukemia (HP:0004808)1.97851740
122Microretrognathia (HP:0000308)1.95302233
123Recurrent cutaneous fungal infections (HP:0011370)1.94957970
124Chronic mucocutaneous candidiasis (HP:0002728)1.94957970
125Duodenal stenosis (HP:0100867)1.94918392
126Small intestinal stenosis (HP:0012848)1.94918392
127Broad-based gait (HP:0002136)1.94902425
128Abnormality of the labia majora (HP:0012881)1.94294329
129Cerebral hypomyelination (HP:0006808)1.93122034
130Aplasia/Hypoplasia of the thymus (HP:0010515)1.91437003
131Increased hepatocellular lipid droplets (HP:0006565)1.90987186
132Abnormality of DNA repair (HP:0003254)1.90814214
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90617455
134Abnormality of alanine metabolism (HP:0010916)1.90617455
135Hyperalaninemia (HP:0003348)1.90617455
136Abnormality of the carotid arteries (HP:0005344)1.90349415
137Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89627755
138Chest pain (HP:0100749)1.88868044
139Abnormality of macular pigmentation (HP:0008002)1.88646249
140Recurrent bacterial skin infections (HP:0005406)1.88552009
141Acute lymphatic leukemia (HP:0006721)1.88271358
142Chronic obstructive pulmonary disease (HP:0006510)1.88213720
143Obstructive lung disease (HP:0006536)1.88213720
1443-Methylglutaconic aciduria (HP:0003535)1.88193180
145Increased mean platelet volume (HP:0011877)1.87876409
146Astigmatism (HP:0000483)1.87643426
147Deviation of the thumb (HP:0009603)1.87307098
148Abnormality of the duodenum (HP:0002246)1.86937242
149Constricted visual fields (HP:0001133)1.86480467
150Medulloblastoma (HP:0002885)1.86453046
151Oligohydramnios (HP:0001562)1.85643762
152Abnormal protein N-linked glycosylation (HP:0012347)1.85545360
153Abnormal protein glycosylation (HP:0012346)1.85545360
154Abnormal glycosylation (HP:0012345)1.85545360
155Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85545360
156Congenital sensorineural hearing impairment (HP:0008527)1.85508036
157Keratoconus (HP:0000563)1.85345684
158Increased corneal curvature (HP:0100692)1.85345684
159Postaxial foot polydactyly (HP:0001830)1.84863274
160Viral hepatitis (HP:0006562)1.83827365
161Trismus (HP:0000211)1.82869882
162Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82409624
163Anencephaly (HP:0002323)1.82244115
164Truncal obesity (HP:0001956)1.81928762
165Congenital primary aphakia (HP:0007707)1.81241316
166Dialeptic seizures (HP:0011146)1.81228181
167Cellular immunodeficiency (HP:0005374)1.81121267
168Abnormal number of incisors (HP:0011064)1.79387353
169Gait imbalance (HP:0002141)1.79141909
170Small hand (HP:0200055)1.77792020
171Gingival bleeding (HP:0000225)1.77223766
172Genital tract atresia (HP:0001827)1.76010618
173Abnormality of the calcaneus (HP:0008364)1.75250039
174Recurrent skin infections (HP:0001581)1.74856306
175Thyroiditis (HP:0100646)1.74573753
176Preaxial hand polydactyly (HP:0001177)1.74517478
177Irregular epiphyses (HP:0010582)1.73340050
178Abnormality of B cell number (HP:0010975)1.72867533
179B lymphocytopenia (HP:0010976)1.72867533
180Ureteral stenosis (HP:0000071)1.72840832
181Abnormal platelet function (HP:0011869)1.72713910
182Impaired platelet aggregation (HP:0003540)1.72713910
183Abnormality of ocular smooth pursuit (HP:0000617)1.72447368
184Scotoma (HP:0000575)1.71902449
185Absence seizures (HP:0002121)1.71856563
186Patellar aplasia (HP:0006443)1.71547778
187Highly arched eyebrow (HP:0002553)1.70733889
188Aplasia/Hypoplasia of the spleen (HP:0010451)1.69871531
189Meningioma (HP:0002858)1.68207682
190Chorioretinal atrophy (HP:0000533)1.66911848
191Vaginal atresia (HP:0000148)1.66681664
192Widely spaced teeth (HP:0000687)1.66385880
193Nephrogenic diabetes insipidus (HP:0009806)1.66143031
194Focal seizures (HP:0007359)1.65241953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.02879308
2CDC73.21783591
3GRK13.05657414
4ADRBK22.81138400
5EIF2AK12.65994766
6MAP4K12.65928614
7WEE12.48716798
8NUAK12.36549970
9STK162.36325997
10BUB12.30709850
11MKNK12.25558684
12LATS12.25430294
13TGFBR12.24035320
14EIF2AK32.20057972
15TEC2.17255377
16TSSK62.16597309
17KIT2.14816574
18WNK32.12725412
19PASK2.04985857
20NME22.04519259
21ACVR1B1.98013413
22BRSK21.89187833
23EEF2K1.85830970
24BMPR1B1.83087123
25BTK1.77018605
26SCYL21.75363952
27PIM21.75247849
28JAK31.71475978
29VRK11.70419390
30STK38L1.70241934
31MKNK21.56498322
32OXSR11.53162445
33RPS6KB21.52890141
34MAP3K101.51048543
35BLK1.49862127
36RPS6KA41.48593908
37ATR1.46993518
38STK101.44357019
39MAPK131.43503314
40FLT31.39856331
41SRPK11.37789549
42STK31.37446553
43MAP3K41.34920575
44TAOK31.32331080
45CDK41.31314824
46TXK1.29681362
47MAP3K81.28496925
48CASK1.28369106
49CDK81.27108923
50NTRK31.26141003
51INSRR1.25043633
52CDK71.22513431
53PNCK1.21509582
54STK391.21073446
55MAP4K21.21053635
56AKT31.19846971
57PINK11.18041215
58PIM11.16495008
59ITK1.14914118
60PLK41.13962935
61NEK21.13176070
62TAOK21.12819940
63TESK21.12609877
64MAP2K31.12348871
65ZAP701.10276495
66PKN21.09608119
67TTK1.09428427
68PLK11.05000428
69CSF1R1.04332327
70CAMKK21.03813076
71AURKB1.03594416
72ERBB31.03329757
73FGFR31.03209270
74IRAK41.01752624
75DYRK30.99786442
76LRRK20.99570309
77TYK20.97735439
78PAK40.97096608
79SYK0.96626119
80TNIK0.94773719
81ADRBK10.90118276
82PIK3CG0.89552127
83GRK60.88182925
84WNK40.88034991
85TLK10.84764201
86LCK0.84265040
87CDK30.84222181
88IKBKB0.82133270
89LYN0.79899885
90PBK0.79645365
91PLK30.79626863
92FGFR20.78710876
93CHEK10.77176663
94CCNB10.75323263
95BCKDK0.73826541
96STK40.73765411
97PRKCE0.72976357
98PLK20.71606320
99KDR0.71041632
100PAK30.69174377
101BRSK10.68858905
102TRPM70.68362558
103ILK0.67632918
104CSNK2A20.63863849
105CLK10.61705341
106ATM0.61418290
107CDK60.60808130
108ALK0.60721141
109MAP3K20.60241213
110PIK3CA0.59899176
111ABL20.59600933
112CSNK1G30.59046902
113MST40.58545429
114CHEK20.58426575
115EPHB10.58258238
116PTK2B0.55568818
117CDK120.54212392
118EIF2AK20.54063966
119BCR0.53945594
120MAPKAPK50.53785882
121FER0.53031678
122DAPK20.52879098
123SGK20.51322973
124ZAK0.51066289
125CSNK1G10.51045309
126MAP3K110.50270588
127CSNK1A1L0.49329997
128CHUK0.49154941
129CDK20.46932586
130IKBKE0.46705456
131ERN10.46561237
132CSNK2A10.46259838
133TAF10.46123168
134FGFR10.46049322
135MAP3K140.45409304
136MAP3K70.44712385
137CAMK1G0.44195920
138CSNK1D0.44131075
139PRKCG0.43942808
140PAK10.43789326
141TRIM280.43024661
142PRKACB0.42228627
143MAPK110.41534696
144NLK0.41112766
145MAPK40.41034397
146AURKA0.40731996
147MATK0.40455287
148RPS6KB10.40432944
149TBK10.40320630
150CAMK2A0.39804560
151WNK10.39639560
152RPS6KA60.39313929
153BMPR20.39162277
154IRAK10.38535663
155DYRK1A0.38245216
156FES0.37656679
157BRD40.36988117
158NEK90.36428947
159MELK0.32963376
160SGK10.32516957
161MUSK0.32169367
162NEK10.31843834
163STK380.31265002
164CSNK1G20.31167843
165TNK20.31038521
166PRKAA20.30371515

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.67159759
2Ribosome_Homo sapiens_hsa030103.78775330
3Mismatch repair_Homo sapiens_hsa034303.48552956
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46293978
5Phototransduction_Homo sapiens_hsa047442.95347084
6Base excision repair_Homo sapiens_hsa034102.88034235
7Spliceosome_Homo sapiens_hsa030402.83979185
8RNA polymerase_Homo sapiens_hsa030202.74336743
9Nitrogen metabolism_Homo sapiens_hsa009102.68148618
10Homologous recombination_Homo sapiens_hsa034402.57132768
11Proteasome_Homo sapiens_hsa030502.54457896
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.54299967
13RNA transport_Homo sapiens_hsa030132.48892556
14One carbon pool by folate_Homo sapiens_hsa006702.45113964
15Nucleotide excision repair_Homo sapiens_hsa034202.41671534
16Butanoate metabolism_Homo sapiens_hsa006502.36875078
17Cell cycle_Homo sapiens_hsa041102.17216600
18Taste transduction_Homo sapiens_hsa047422.13697161
19Pyrimidine metabolism_Homo sapiens_hsa002402.12583223
20Nicotine addiction_Homo sapiens_hsa050332.03299711
21Linoleic acid metabolism_Homo sapiens_hsa005912.03041619
22Non-homologous end-joining_Homo sapiens_hsa034501.97628582
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.96447708
24Tryptophan metabolism_Homo sapiens_hsa003801.93660743
25Ether lipid metabolism_Homo sapiens_hsa005651.90737188
26Olfactory transduction_Homo sapiens_hsa047401.90449262
27Antigen processing and presentation_Homo sapiens_hsa046121.89601456
28RNA degradation_Homo sapiens_hsa030181.85320020
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85103510
30Primary immunodeficiency_Homo sapiens_hsa053401.84776679
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84044129
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83897621
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.83747946
34Propanoate metabolism_Homo sapiens_hsa006401.75241721
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.73536275
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68194602
37ABC transporters_Homo sapiens_hsa020101.55800803
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55674766
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.51536775
40Fanconi anemia pathway_Homo sapiens_hsa034601.47600057
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39076213
42Protein export_Homo sapiens_hsa030601.36484446
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36198776
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35724984
45Basal transcription factors_Homo sapiens_hsa030221.33792636
46Morphine addiction_Homo sapiens_hsa050321.32900182
47Serotonergic synapse_Homo sapiens_hsa047261.32693062
48Herpes simplex infection_Homo sapiens_hsa051681.31679760
49p53 signaling pathway_Homo sapiens_hsa041151.27347638
50Retinol metabolism_Homo sapiens_hsa008301.21252026
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18202407
52Circadian entrainment_Homo sapiens_hsa047131.15802047
53Histidine metabolism_Homo sapiens_hsa003401.15373109
54Dorso-ventral axis formation_Homo sapiens_hsa043201.14295337
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12464114
56Systemic lupus erythematosus_Homo sapiens_hsa053221.11092634
57Glutamatergic synapse_Homo sapiens_hsa047241.10660167
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10355891
59Epstein-Barr virus infection_Homo sapiens_hsa051691.09885772
60Measles_Homo sapiens_hsa051621.08359397
61Pentose phosphate pathway_Homo sapiens_hsa000301.06801468
62mRNA surveillance pathway_Homo sapiens_hsa030151.06654869
63Lysine degradation_Homo sapiens_hsa003101.05783825
64Leishmaniasis_Homo sapiens_hsa051401.04558866
65Sulfur relay system_Homo sapiens_hsa041221.04428510
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04009093
67Chemical carcinogenesis_Homo sapiens_hsa052041.03704256
68Purine metabolism_Homo sapiens_hsa002301.03695954
69NF-kappa B signaling pathway_Homo sapiens_hsa040641.02609984
70GABAergic synapse_Homo sapiens_hsa047270.99991237
71Calcium signaling pathway_Homo sapiens_hsa040200.97023300
72Allograft rejection_Homo sapiens_hsa053300.94371115
73Salivary secretion_Homo sapiens_hsa049700.94301380
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93932776
75N-Glycan biosynthesis_Homo sapiens_hsa005100.93063667
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91454643
77Viral carcinogenesis_Homo sapiens_hsa052030.91399441
78Sphingolipid metabolism_Homo sapiens_hsa006000.91376733
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91037212
80Legionellosis_Homo sapiens_hsa051340.91027198
81Glycerolipid metabolism_Homo sapiens_hsa005610.89923712
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.89317168
83Hematopoietic cell lineage_Homo sapiens_hsa046400.86985130
84Caffeine metabolism_Homo sapiens_hsa002320.83023124
85B cell receptor signaling pathway_Homo sapiens_hsa046620.82279755
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.81827676
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81483352
88Biosynthesis of amino acids_Homo sapiens_hsa012300.81370337
89Long-term depression_Homo sapiens_hsa047300.79301377
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.78516648
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76411808
92Selenocompound metabolism_Homo sapiens_hsa004500.76071054
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.74564833
94Ovarian steroidogenesis_Homo sapiens_hsa049130.72903611
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71419324
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71259496
97Fatty acid biosynthesis_Homo sapiens_hsa000610.70905668
98Thyroid cancer_Homo sapiens_hsa052160.70622177
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70551792
100Circadian rhythm_Homo sapiens_hsa047100.70208665
101HTLV-I infection_Homo sapiens_hsa051660.69164903
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68211198
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67339655
104Vitamin B6 metabolism_Homo sapiens_hsa007500.65711654
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65265476
106T cell receptor signaling pathway_Homo sapiens_hsa046600.64748277
107Hepatitis B_Homo sapiens_hsa051610.63947123
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63350727
109Cholinergic synapse_Homo sapiens_hsa047250.63111784
110Graft-versus-host disease_Homo sapiens_hsa053320.62730061
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62411125
112Peroxisome_Homo sapiens_hsa041460.61652678
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61306086
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61080664
115Influenza A_Homo sapiens_hsa051640.60518306
116beta-Alanine metabolism_Homo sapiens_hsa004100.60101415
117Acute myeloid leukemia_Homo sapiens_hsa052210.59862779
118Renin secretion_Homo sapiens_hsa049240.59371454
119Shigellosis_Homo sapiens_hsa051310.59327606
120Arachidonic acid metabolism_Homo sapiens_hsa005900.59025533
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.57872164
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.57686019
123Malaria_Homo sapiens_hsa051440.57472718
124Apoptosis_Homo sapiens_hsa042100.56172980
125Toxoplasmosis_Homo sapiens_hsa051450.54952002
126TGF-beta signaling pathway_Homo sapiens_hsa043500.54583898
127Small cell lung cancer_Homo sapiens_hsa052220.51327580
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50973307
129Oocyte meiosis_Homo sapiens_hsa041140.50755921
130Insulin secretion_Homo sapiens_hsa049110.50084604
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49855107
132Oxytocin signaling pathway_Homo sapiens_hsa049210.47764527
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46387459
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46205860
135Dopaminergic synapse_Homo sapiens_hsa047280.45385831
136Folate biosynthesis_Homo sapiens_hsa007900.44654069
137Osteoclast differentiation_Homo sapiens_hsa043800.43868515
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42300068
139Vitamin digestion and absorption_Homo sapiens_hsa049770.41218965
140cAMP signaling pathway_Homo sapiens_hsa040240.41027060
141Alcoholism_Homo sapiens_hsa050340.40991346
142Viral myocarditis_Homo sapiens_hsa054160.40111533
143Carbon metabolism_Homo sapiens_hsa012000.40087904
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39588637
145Type I diabetes mellitus_Homo sapiens_hsa049400.38500006
146Chronic myeloid leukemia_Homo sapiens_hsa052200.38001648
147Asthma_Homo sapiens_hsa053100.36531934
148Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35245836
149Colorectal cancer_Homo sapiens_hsa052100.34413039
150Non-small cell lung cancer_Homo sapiens_hsa052230.34254077
151Amphetamine addiction_Homo sapiens_hsa050310.34224742
152Hedgehog signaling pathway_Homo sapiens_hsa043400.34086901
153Tuberculosis_Homo sapiens_hsa051520.34009320
154cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33795905
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32441385
156Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31530841
157Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31357668
158Parkinsons disease_Homo sapiens_hsa050120.30071036
159HIF-1 signaling pathway_Homo sapiens_hsa040660.28688210
160Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28151409
161MicroRNAs in cancer_Homo sapiens_hsa052060.27520967
162Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25992481
163Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25373987
164Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25075512
1652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24353376
166Salmonella infection_Homo sapiens_hsa051320.23636853
167Leukocyte transendothelial migration_Homo sapiens_hsa046700.22780066
168Pancreatic cancer_Homo sapiens_hsa052120.22487389
169Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21658691
170Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20738299
171Platelet activation_Homo sapiens_hsa046110.20620050

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