PUSL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.31106399
2ribosomal small subunit assembly (GO:0000028)5.74788217
3maturation of SSU-rRNA (GO:0030490)5.34781951
4proteasome assembly (GO:0043248)4.85098433
5viral transcription (GO:0019083)4.81040341
6telomere maintenance via semi-conservative replication (GO:0032201)4.72752136
7DNA strand elongation involved in DNA replication (GO:0006271)4.71973534
8translational termination (GO:0006415)4.70536383
9ribosome biogenesis (GO:0042254)4.55707052
10DNA strand elongation (GO:0022616)4.55008315
11nucleobase biosynthetic process (GO:0046112)4.51713626
12DNA replication initiation (GO:0006270)4.49498913
13formation of translation preinitiation complex (GO:0001731)4.48277170
14ribonucleoprotein complex biogenesis (GO:0022613)4.43573817
15ribosomal large subunit biogenesis (GO:0042273)4.41945214
16ribosomal small subunit biogenesis (GO:0042274)4.41617596
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.38101415
18translational elongation (GO:0006414)4.36042097
19transcription elongation from RNA polymerase III promoter (GO:0006385)4.30926787
20termination of RNA polymerase III transcription (GO:0006386)4.30926787
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.24380397
22* pseudouridine synthesis (GO:0001522)4.20964043
23GDP-mannose metabolic process (GO:0019673)4.16096048
24cotranslational protein targeting to membrane (GO:0006613)4.14951421
25translational initiation (GO:0006413)4.14700320
26purine nucleobase biosynthetic process (GO:0009113)4.11965781
27protein targeting to ER (GO:0045047)4.11145363
28guanosine-containing compound biosynthetic process (GO:1901070)4.07452390
29spliceosomal snRNP assembly (GO:0000387)4.05944600
30telomere maintenance via recombination (GO:0000722)4.02652476
31rRNA processing (GO:0006364)4.00480944
32protein localization to endoplasmic reticulum (GO:0070972)3.90791811
33pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.89201101
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.88821324
35rRNA metabolic process (GO:0016072)3.88053727
36rRNA modification (GO:0000154)3.86935375
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.86620117
38UTP biosynthetic process (GO:0006228)3.84807407
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84059076
40chaperone-mediated protein transport (GO:0072321)3.82160952
41ribosome assembly (GO:0042255)3.81972466
42DNA replication checkpoint (GO:0000076)3.80192586
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.76608343
44translation (GO:0006412)3.76249317
45viral life cycle (GO:0019058)3.73562542
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.73257093
47viral mRNA export from host cell nucleus (GO:0046784)3.70472956
48DNA unwinding involved in DNA replication (GO:0006268)3.69381397
49pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.69195517
50cellular component biogenesis (GO:0044085)3.68569761
51telomere maintenance via telomere lengthening (GO:0010833)3.67345972
52peptidyl-histidine modification (GO:0018202)3.66021509
53cellular protein complex disassembly (GO:0043624)3.65848437
54GTP biosynthetic process (GO:0006183)3.65562673
55establishment of protein localization to mitochondrial membrane (GO:0090151)3.58614927
56proline biosynthetic process (GO:0006561)3.58251433
57energy coupled proton transport, down electrochemical gradient (GO:0015985)3.57625634
58ATP synthesis coupled proton transport (GO:0015986)3.57625634
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.57225232
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.56626861
61mitotic recombination (GO:0006312)3.56529613
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.55135601
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.53949938
64negative regulation of ligase activity (GO:0051352)3.53949938
65tRNA methylation (GO:0030488)3.51769201
66pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.50004326
67regulation of mitochondrial translation (GO:0070129)3.49938658
68establishment of protein localization to mitochondrion (GO:0072655)3.49402267
69nucleobase-containing small molecule interconversion (GO:0015949)3.47527341
70heterochromatin organization (GO:0070828)3.45183345
71IMP biosynthetic process (GO:0006188)3.40608246
72transcription-coupled nucleotide-excision repair (GO:0006283)3.40336927
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.39739473
747-methylguanosine mRNA capping (GO:0006370)3.38704661
75UTP metabolic process (GO:0046051)3.34967230
762-deoxyribonucleotide biosynthetic process (GO:0009265)3.34916859
77deoxyribose phosphate biosynthetic process (GO:0046385)3.34916859
78CTP biosynthetic process (GO:0006241)3.34372568
79CTP metabolic process (GO:0046036)3.34372568
80L-serine metabolic process (GO:0006563)3.34078165
81regulation of cellular amino acid metabolic process (GO:0006521)3.34073291
82establishment of integrated proviral latency (GO:0075713)3.33470107
83mitochondrial respiratory chain complex I assembly (GO:0032981)3.33142767
84NADH dehydrogenase complex assembly (GO:0010257)3.33142767
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33142767
86DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33085157
87mitochondrial respiratory chain complex assembly (GO:0033108)3.32600147
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.30973794
89RNA capping (GO:0036260)3.30674826
907-methylguanosine RNA capping (GO:0009452)3.30674826
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28610693
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28610693
93pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.28306390
94protein deneddylation (GO:0000338)3.27495007
95protein maturation by protein folding (GO:0022417)3.26913190
96iron-sulfur cluster assembly (GO:0016226)3.26840207
97metallo-sulfur cluster assembly (GO:0031163)3.26840207
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.26697878
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.26697878
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.26697878
101protein complex disassembly (GO:0043241)3.26680969
102cullin deneddylation (GO:0010388)3.26424903
103* ncRNA processing (GO:0034470)3.22961494
104protein localization to mitochondrion (GO:0070585)3.22622647
105folic acid metabolic process (GO:0046655)3.22579175
106protein complex biogenesis (GO:0070271)3.22371531
107base-excision repair, AP site formation (GO:0006285)3.22317230
108cell cycle G1/S phase transition (GO:0044843)3.22026596
109G1/S transition of mitotic cell cycle (GO:0000082)3.22026596
110exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18877350
111CENP-A containing nucleosome assembly (GO:0034080)3.18254415
112regulation of translational fidelity (GO:0006450)3.15826265
113tRNA modification (GO:0006400)3.15601573
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.15432801
115RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.15432801
116signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15412886
117signal transduction involved in DNA damage checkpoint (GO:0072422)3.15412886
118signal transduction involved in cell cycle checkpoint (GO:0072395)3.15199896
119pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.15111726
120macromolecular complex disassembly (GO:0032984)3.13246903
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.12986185
122* ncRNA metabolic process (GO:0034660)3.12475907
123protein targeting to mitochondrion (GO:0006626)3.11621369
124maturation of 5.8S rRNA (GO:0000460)3.10647314
125spliceosomal complex assembly (GO:0000245)3.09584883
126rRNA methylation (GO:0031167)3.09509574
127nuclear envelope reassembly (GO:0031468)3.09277039
128mitotic nuclear envelope reassembly (GO:0007084)3.09277039
129regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09172513
130GMP metabolic process (GO:0046037)3.09152389
131termination of RNA polymerase I transcription (GO:0006363)3.08826670
132nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08206000
133transcription from RNA polymerase I promoter (GO:0006360)3.07554139
134transcription elongation from RNA polymerase I promoter (GO:0006362)3.05607531
135positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04565616
136nuclear-transcribed mRNA catabolic process (GO:0000956)3.03323477
137ncRNA 3-end processing (GO:0043628)3.02731141
138folic acid-containing compound biosynthetic process (GO:0009396)3.02232714
139peptidyl-arginine omega-N-methylation (GO:0035247)3.01987953
140negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.00993904
141rRNA transcription (GO:0009303)3.00901048
142deoxyribonucleotide biosynthetic process (GO:0009263)2.93799920
143establishment of viral latency (GO:0019043)2.93683807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.64374891
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.75358321
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.37637895
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.82910376
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.81380257
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.65749241
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.56615101
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.52301495
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.47365995
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.42463571
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.27033992
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10938249
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99287183
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.95686404
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58112125
16VDR_23849224_ChIP-Seq_CD4+_Human2.57712506
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.57619640
18XRN2_22483619_ChIP-Seq_HELA_Human2.54591367
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47343535
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46374134
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.43533661
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39525180
23DCP1A_22483619_ChIP-Seq_HELA_Human2.33723009
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28209355
25GABP_19822575_ChIP-Seq_HepG2_Human2.25880288
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24040744
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19797041
28* FOXP3_21729870_ChIP-Seq_TREG_Human2.15441876
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.12040358
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08525158
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.04559031
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04108923
33TTF2_22483619_ChIP-Seq_HELA_Human2.03771290
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.96485117
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92171182
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91120201
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90007958
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88123527
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87334204
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86613264
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82844816
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80161769
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78788817
44CIITA_25753668_ChIP-Seq_RAJI_Human1.70683941
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63095894
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63049078
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62536468
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61846972
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61670068
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60525043
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60445854
52ELK1_19687146_ChIP-ChIP_HELA_Human1.57222864
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57061335
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52534594
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52213337
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.48883686
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.47902815
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42740074
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.40486071
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39183848
61LXR_22292898_ChIP-Seq_THP-1_Human1.37389985
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34891916
63MYC_22102868_ChIP-Seq_BL_Human1.34111382
64KDM5A_27292631_Chip-Seq_BREAST_Human1.30869561
65ZNF263_19887448_ChIP-Seq_K562_Human1.30692967
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26275652
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.25445850
68P68_20966046_ChIP-Seq_HELA_Human1.25386302
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24900387
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.24427811
71AR_21909140_ChIP-Seq_LNCAP_Human1.22164151
72* RACK7_27058665_Chip-Seq_MCF-7_Human1.20435537
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18344615
74MYC_18940864_ChIP-ChIP_HL60_Human1.14794530
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13406657
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12995586
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.12420992
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11897234
79SPI1_23547873_ChIP-Seq_NB4_Human1.09414796
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09320402
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08745014
82* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08605313
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08066419
84VDR_21846776_ChIP-Seq_THP-1_Human1.07716799
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07648016
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06556127
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06484501
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06473116
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05793923
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.05685995
91TFEB_21752829_ChIP-Seq_HELA_Human1.04158471
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03795064
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03431036
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02371964
95TP63_17297297_ChIP-ChIP_HaCaT_Human1.01511848
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.01076890
97BCL6_27268052_Chip-Seq_Bcells_Human0.99669236
98CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99406739
99RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97774977
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97147291
101CTCF_26484167_Chip-Seq_Bcells_Mouse0.95592175
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95111738
103* MAF_26560356_Chip-Seq_TH2_Human0.94918442
104RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94856076
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93970314
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93943555
107BCOR_27268052_Chip-Seq_Bcells_Human0.92807770
108PHF8_20622854_ChIP-Seq_HELA_Human0.92562075
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91999162
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89257609
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89016621
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85149607
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83787574
114YY1_22570637_ChIP-Seq_MALME-3M_Human0.83281784
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82631984
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81218035
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79458055
118CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79062727
119SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78532627
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78231175
121EGR1_19374776_ChIP-ChIP_THP-1_Human0.77243305
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76857284
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.74366272

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.85626589
2MP0004957_abnormal_blastocyst_morpholog4.17285708
3MP0003111_abnormal_nucleus_morphology3.95970618
4MP0010094_abnormal_chromosome_stability3.89871651
5MP0003077_abnormal_cell_cycle3.56178497
6MP0002396_abnormal_hematopoietic_system3.46583915
7MP0008058_abnormal_DNA_repair3.43068289
8MP0008007_abnormal_cellular_replicative3.00075323
9MP0008057_abnormal_DNA_replication2.92661013
10MP0008932_abnormal_embryonic_tissue2.66744799
11MP0006292_abnormal_olfactory_placode2.48611767
12MP0001346_abnormal_lacrimal_gland2.37909788
13MP0009379_abnormal_foot_pigmentation2.35546471
14MP0000490_abnormal_crypts_of2.20923326
15MP0005451_abnormal_body_composition2.18575825
16MP0002163_abnormal_gland_morphology2.14671361
17MP0009333_abnormal_splenocyte_physiolog2.01276937
18MP0005501_abnormal_skin_physiology1.93056773
19MP0004185_abnormal_adipocyte_glucose1.92921173
20MP0003786_premature_aging1.89160587
21MP0000678_abnormal_parathyroid_gland1.85736168
22MP0001545_abnormal_hematopoietic_system1.83968724
23MP0005397_hematopoietic_system_phenotyp1.83968724
24MP0003123_paternal_imprinting1.83821896
25MP0003806_abnormal_nucleotide_metabolis1.83034404
26MP0002132_abnormal_respiratory_system1.81321632
27MP0000350_abnormal_cell_proliferation1.80829885
28MP0005075_abnormal_melanosome_morpholog1.78305602
29MP0003656_abnormal_erythrocyte_physiolo1.71689307
30MP0003718_maternal_effect1.71435468
31MP0004233_abnormal_muscle_weight1.69381123
32MP0003763_abnormal_thymus_physiology1.69094327
33MP0001661_extended_life_span1.66550608
34MP0003136_yellow_coat_color1.62435999
35MP0005174_abnormal_tail_pigmentation1.60410272
36MP0004808_abnormal_hematopoietic_stem1.58751721
37MP0004147_increased_porphyrin_level1.57423735
38MP0002877_abnormal_melanocyte_morpholog1.56789470
39MP0003705_abnormal_hypodermis_morpholog1.56289157
40MP0006036_abnormal_mitochondrial_physio1.56023071
41MP0003186_abnormal_redox_activity1.54919819
42MP0000537_abnormal_urethra_morphology1.53280295
43MP0006035_abnormal_mitochondrial_morpho1.53156169
44MP0005623_abnormal_meninges_morphology1.53135801
45MP0000358_abnormal_cell_content/1.50548857
46MP0002234_abnormal_pharynx_morphology1.48148218
47MP0001730_embryonic_growth_arrest1.47538147
48MP0002398_abnormal_bone_marrow1.45211021
49MP0000313_abnormal_cell_death1.42672968
50MP0004858_abnormal_nervous_system1.40817552
51MP0005083_abnormal_biliary_tract1.39330916
52MP0003315_abnormal_perineum_morphology1.37307190
53MP0002796_impaired_skin_barrier1.36959518
54MP0000689_abnormal_spleen_morphology1.34888095
55MP0002019_abnormal_tumor_incidence1.34366614
56MP0006054_spinal_hemorrhage1.32594507
57MP0002722_abnormal_immune_system1.27679770
58MP0002249_abnormal_larynx_morphology1.26866220
59MP0000465_gastrointestinal_hemorrhage1.26678400
60MP0010307_abnormal_tumor_latency1.25111821
61MP0001853_heart_inflammation1.24949948
62MP0002080_prenatal_lethality1.24183862
63MP0005671_abnormal_response_to1.24117575
64MP0002095_abnormal_skin_pigmentation1.20536867
65MP0003646_muscle_fatigue1.20104997
66MP0008789_abnormal_olfactory_epithelium1.19153015
67MP0002429_abnormal_blood_cell1.17843264
68MP0000049_abnormal_middle_ear1.17209982
69MP0000703_abnormal_thymus_morphology1.16211174
70MP0000003_abnormal_adipose_tissue1.14120666
71MP0003453_abnormal_keratinocyte_physiol1.10315205
72MP0001697_abnormal_embryo_size1.08392190
73MP0005058_abnormal_lysosome_morphology1.08108975
74MP0009053_abnormal_anal_canal1.07580530
75MP0002111_abnormal_tail_morphology1.06790719
76MP0008877_abnormal_DNA_methylation1.03874870
77MP0003567_abnormal_fetal_cardiomyocyte1.03837537
78MP0000015_abnormal_ear_pigmentation1.01875428
79MP0000750_abnormal_muscle_regeneration1.01585897
80MP0002160_abnormal_reproductive_system1.01523655
81MP0002697_abnormal_eye_size0.99713351
82MP0000716_abnormal_immune_system0.99294121
83MP0005394_taste/olfaction_phenotype0.98439156
84MP0005499_abnormal_olfactory_system0.98439156
85MP0000685_abnormal_immune_system0.96573752
86MP0002210_abnormal_sex_determination0.95975775
87MP0005330_cardiomyopathy0.95918351
88MP0001835_abnormal_antigen_presentation0.91274530
89MP0000858_altered_metastatic_potential0.89954032
90MP0000681_abnormal_thyroid_gland0.88577386
91MP0002084_abnormal_developmental_patter0.87192415
92MP0003942_abnormal_urinary_system0.86880979
93MP0009672_abnormal_birth_weight0.86665427
94MP0005171_absent_coat_pigmentation0.86253826
95MP0003937_abnormal_limbs/digits/tail_de0.85348688
96MP0010771_integument_phenotype0.83607793
97MP0001145_abnormal_male_reproductive0.82955491
98MP0001919_abnormal_reproductive_system0.82714344
99MP0002420_abnormal_adaptive_immunity0.82008062
100MP0001672_abnormal_embryogenesis/_devel0.79614070
101MP0005380_embryogenesis_phenotype0.79614070
102MP0001819_abnormal_immune_cell0.79391583
103MP0002751_abnormal_autonomic_nervous0.78134260
104MP0005332_abnormal_amino_acid0.77960122
105MP0005076_abnormal_cell_differentiation0.76731957
106MP0002653_abnormal_ependyma_morphology0.76328262
107MP0001764_abnormal_homeostasis0.76183732
108MP0002177_abnormal_outer_ear0.75812087
109MP0008260_abnormal_autophagy0.75791099
110MP0001727_abnormal_embryo_implantation0.75093712
111MP0002089_abnormal_postnatal_growth/wei0.74716305
112MP0005384_cellular_phenotype0.74312854
113MP0001529_abnormal_vocalization0.74282356
114MP0002085_abnormal_embryonic_tissue0.73186306
115MP0005379_endocrine/exocrine_gland_phen0.73029462
116MP0010030_abnormal_orbit_morphology0.72251783
117MP0001800_abnormal_humoral_immune0.71235821
118MP0002086_abnormal_extraembryonic_tissu0.70698284
119MP0002452_abnormal_antigen_presenting0.70440197
120MP0002723_abnormal_immune_serum0.70031779
121MP0002736_abnormal_nociception_after0.69678127
122MP0003436_decreased_susceptibility_to0.69416862
123MP0002092_abnormal_eye_morphology0.69269883
124MP0001216_abnormal_epidermal_layer0.68766443
125MP0001188_hyperpigmentation0.68509951
126MP0000538_abnormal_urinary_bladder0.67912760
127MP0001986_abnormal_taste_sensitivity0.67220198
128MP0001119_abnormal_female_reproductive0.67103983
129MP0000653_abnormal_sex_gland0.67011636
130MP0003941_abnormal_skin_development0.66238160
131MP0009697_abnormal_copulation0.66036006
132MP0001293_anophthalmia0.65950508
133MP0009250_abnormal_appendicular_skeleto0.65880384
134MP0003866_abnormal_defecation0.65769624
135MP0005266_abnormal_metabolism0.65522076
136MP0002075_abnormal_coat/hair_pigmentati0.65433520
137MP0005389_reproductive_system_phenotype0.65124453
138MP0001929_abnormal_gametogenesis0.64723091
139MP0002102_abnormal_ear_morphology0.64651739
140MP0003984_embryonic_growth_retardation0.64612775
141MP0002405_respiratory_system_inflammati0.64575283
142MP0003221_abnormal_cardiomyocyte_apopto0.64300453
143MP0000733_abnormal_muscle_development0.64000748
144MP0002060_abnormal_skin_morphology0.62834679
145MP0001873_stomach_inflammation0.61377704
146MP0001881_abnormal_mammary_gland0.60248063
147MP0005375_adipose_tissue_phenotype0.59634661
148MP0002088_abnormal_embryonic_growth/wei0.59523294
149MP0009785_altered_susceptibility_to0.59464113

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.30436488
2Abnormality of cells of the erythroid lineage (HP:0012130)5.27578987
3Aplastic anemia (HP:0001915)4.75598212
4Reticulocytopenia (HP:0001896)4.40041053
5Testicular atrophy (HP:0000029)4.39726963
6Birth length less than 3rd percentile (HP:0003561)4.39364159
7Oral leukoplakia (HP:0002745)4.05258701
8Cerebral hypomyelination (HP:0006808)3.79787818
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.68137111
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.68137111
11Rough bone trabeculation (HP:0100670)3.63168687
12Abnormality of the heme biosynthetic pathway (HP:0010472)3.62915189
13Hepatocellular necrosis (HP:0001404)3.50910203
14Type I transferrin isoform profile (HP:0003642)3.48741531
15Macrocytic anemia (HP:0001972)3.42314962
16Pallor (HP:0000980)3.30598385
17Reduced antithrombin III activity (HP:0001976)3.29558182
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.25900652
19Increased serum lactate (HP:0002151)3.12597626
20Ragged-red muscle fibers (HP:0003200)3.11645662
21Increased hepatocellular lipid droplets (HP:0006565)3.09834247
22Mitochondrial inheritance (HP:0001427)3.05245770
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.03270481
24Microretrognathia (HP:0000308)3.02300284
25Broad distal phalanx of finger (HP:0009836)3.01466685
26Premature graying of hair (HP:0002216)2.99350536
27Colon cancer (HP:0003003)2.99261257
28Squamous cell carcinoma (HP:0002860)2.96127065
29Increased CSF lactate (HP:0002490)2.94583973
30Degeneration of anterior horn cells (HP:0002398)2.94262524
31Abnormality of the anterior horn cell (HP:0006802)2.94262524
32Progressive macrocephaly (HP:0004481)2.85185427
33Hepatic necrosis (HP:0002605)2.83506481
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.81269330
35Pancytopenia (HP:0001876)2.80932959
36Carpal bone hypoplasia (HP:0001498)2.80635927
373-Methylglutaconic aciduria (HP:0003535)2.80502602
38Irregular epiphyses (HP:0010582)2.79778401
39Thrombocytosis (HP:0001894)2.73994854
40Petechiae (HP:0000967)2.70848951
41Breast hypoplasia (HP:0003187)2.69577090
42Acute necrotizing encephalopathy (HP:0006965)2.64722654
43Cerebral edema (HP:0002181)2.60950611
44Exertional dyspnea (HP:0002875)2.60414187
45Lipid accumulation in hepatocytes (HP:0006561)2.59082118
46Abnormal protein glycosylation (HP:0012346)2.56544478
47Abnormal glycosylation (HP:0012345)2.56544478
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.56544478
49Abnormal protein N-linked glycosylation (HP:0012347)2.56544478
50Abnormal mitochondria in muscle tissue (HP:0008316)2.52722938
51Patellar aplasia (HP:0006443)2.50595390
52Abnormality of alanine metabolism (HP:0010916)2.50594201
53Hyperalaninemia (HP:0003348)2.50594201
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50594201
55Truncus arteriosus (HP:0001660)2.47315031
56Increased intramyocellular lipid droplets (HP:0012240)2.44154239
57Respiratory difficulties (HP:0002880)2.40341706
58Trismus (HP:0000211)2.40328276
59Microvesicular hepatic steatosis (HP:0001414)2.40006404
60Abnormal trabecular bone morphology (HP:0100671)2.38802469
61CNS hypomyelination (HP:0003429)2.37199339
62Aplasia/Hypoplasia of the patella (HP:0006498)2.34605665
63Postnatal microcephaly (HP:0005484)2.33349334
64Abnormal umbilical cord blood vessels (HP:0011403)2.32954077
65Single umbilical artery (HP:0001195)2.32954077
66Abnormality of the fetal cardiovascular system (HP:0010948)2.32954077
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31517086
68Abnormality of the umbilical cord (HP:0010881)2.31438344
69Abnormality of the columella (HP:0009929)2.31320061
70Abnormality of the preputium (HP:0100587)2.30365869
71Bone marrow hypocellularity (HP:0005528)2.30180564
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26919173
73Selective tooth agenesis (HP:0001592)2.26213559
74Lactic acidosis (HP:0003128)2.25414176
75Multiple enchondromatosis (HP:0005701)2.25299869
76Progressive muscle weakness (HP:0003323)2.25193604
77Hypoplastic pelvis (HP:0008839)2.24357569
78Renal Fanconi syndrome (HP:0001994)2.23158634
79Vaginal fistula (HP:0004320)2.22059461
80Ulnar bowing (HP:0003031)2.21972942
81Abnormality of glycolysis (HP:0004366)2.20333931
82Increased serum pyruvate (HP:0003542)2.20333931
83Hypokinesia (HP:0002375)2.19509447
84Severe visual impairment (HP:0001141)2.19391968
85Redundant skin (HP:0001582)2.18597216
86Exercise intolerance (HP:0003546)2.18061489
87Absent thumb (HP:0009777)2.17507376
88Cellular immunodeficiency (HP:0005374)2.17476533
89Unsteady gait (HP:0002317)2.17198017
90Hyperthyroidism (HP:0000836)2.17170991
91Agnosia (HP:0010524)2.17137766
92Hypoplasia of the pons (HP:0012110)2.16298636
93Sparse eyelashes (HP:0000653)2.13471881
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.11515632
95Abnormal number of incisors (HP:0011064)2.11166844
96Poor head control (HP:0002421)2.10611872
97Meckel diverticulum (HP:0002245)2.09613437
98Megaloblastic anemia (HP:0001889)2.09290899
99Rectal fistula (HP:0100590)2.08679518
100Rectovaginal fistula (HP:0000143)2.08679518
101Abnormality of the ileum (HP:0001549)2.08579987
10211 pairs of ribs (HP:0000878)2.08272540
103Emotional lability (HP:0000712)2.08091915
104Myelodysplasia (HP:0002863)2.07881168
105Entropion (HP:0000621)2.07802710
106Progressive microcephaly (HP:0000253)2.07686074
107Patent foramen ovale (HP:0001655)2.06747193
108Glossoptosis (HP:0000162)2.05996187
109Premature ovarian failure (HP:0008209)2.04062949
110Cutaneous melanoma (HP:0012056)2.01052276
111Secondary amenorrhea (HP:0000869)1.99203028
112Abnormality of the distal phalanges of the toes (HP:0010182)1.98746619
113Rib fusion (HP:0000902)1.96790256
114Abnormality of the pons (HP:0007361)1.94170019
115Horseshoe kidney (HP:0000085)1.94018425
116Opisthotonus (HP:0002179)1.93627626
117Cleft eyelid (HP:0000625)1.91999218
118Acute encephalopathy (HP:0006846)1.90798555
119Increased muscle lipid content (HP:0009058)1.90586049
120Abnormalities of placenta or umbilical cord (HP:0001194)1.90145928
121Elevated erythrocyte sedimentation rate (HP:0003565)1.89803533
122Septate vagina (HP:0001153)1.88329261
123Death in infancy (HP:0001522)1.88281318
124Poikiloderma (HP:0001029)1.87690742
125Achilles tendon contracture (HP:0001771)1.86608045
126Short middle phalanx of the 5th finger (HP:0004220)1.86243128
127Respiratory failure (HP:0002878)1.86202736
128Delusions (HP:0000746)1.84885831
129Facial cleft (HP:0002006)1.84634187
130CNS demyelination (HP:0007305)1.84207751
131Lymphoma (HP:0002665)1.83315681
132Flat capital femoral epiphysis (HP:0003370)1.82725620
133Amaurosis fugax (HP:0100576)1.82721397
134Muscle fiber atrophy (HP:0100295)1.82662618
135Intestinal fistula (HP:0100819)1.78896326
136Hypertensive crisis (HP:0100735)1.78616984
137Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76887364
138Short thumb (HP:0009778)1.76222778
139Nonimmune hydrops fetalis (HP:0001790)1.74511951
140Gout (HP:0001997)1.74124777
141Absent radius (HP:0003974)1.73140104
142Aplasia involving forearm bones (HP:0009822)1.72998832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.05429285
2NME23.88497418
3WEE13.88120382
4STK163.76846531
5VRK23.55250746
6EIF2AK13.09047993
7SMG12.83819596
8EIF2AK32.79732569
9PIM22.77293391
10ACVR1B2.75466257
11TNIK2.68922285
12CDC72.49626635
13TSSK62.33320281
14SRPK12.26620976
15VRK12.18142014
16TRIB32.03913181
17EPHA21.89000968
18TLK11.87027006
19BRSK21.86757876
20TESK21.78832093
21DYRK31.64222932
22MKNK11.58662163
23SCYL21.57728940
24CCNB11.56589816
25PBK1.49942211
26MAP3K121.46721307
27MAP3K111.43013342
28CDK81.42349870
29NME11.41280175
30CDK71.38540503
31TGFBR11.36481988
32MKNK21.36083412
33BCKDK1.33496021
34PLK11.28599262
35FLT31.24872715
36KDR1.24389799
37RPS6KA51.20625133
38MAP2K31.18845925
39TAOK21.18435024
40BRAF1.17967633
41CSNK1G31.15947177
42BRSK11.14225340
43SIK11.12077334
44ARAF1.10318501
45AURKA1.07467231
46RPS6KA41.05093016
47STK41.04996458
48MAP4K11.03438446
49CDK191.03298594
50MAPK151.02689584
51AURKB1.02165088
52RPS6KB21.00574356
53KIT0.99859860
54ATR0.98445098
55PLK40.96150286
56MUSK0.91190563
57DAPK10.91146931
58PLK30.89807247
59NEK10.89090449
60RAF10.88851515
61CSNK1A1L0.88308291
62NEK20.88117720
63IRAK30.87894024
64TEC0.86974715
65ILK0.84795423
66PDK20.84092429
67CDK40.83253159
68TTK0.83012419
69ADRBK20.81282156
70CHEK20.79310835
71EIF2AK20.79208249
72PAK40.78926691
73CSNK1G10.76849248
74CAMKK20.76267248
75IRAK40.76203093
76PASK0.76093964
77IRAK20.75366081
78TAF10.73633999
79PIM10.71792459
80ZAP700.71671406
81ICK0.69444796
82MAP3K100.67559492
83CSNK2A20.67446713
84BLK0.66863402
85BTK0.66541733
86AKT20.66113541
87CSNK2A10.64415922
88NLK0.63789753
89TESK10.60968818
90PAK10.60106411
91MAP3K80.58890960
92MST1R0.57019663
93CSNK1G20.53597243
94LRRK20.53569344
95YES10.53032922
96GRK60.51202343
97CHEK10.50806581
98PRKCI0.50511857
99CSF1R0.49521899
100DYRK20.48724248
101TAOK10.45437602
102MAP3K30.44862942
103IKBKB0.42629160
104MAPK110.41916115
105MAP3K60.41219610
106STK100.40933406
107CDK20.40921041
108CASK0.39412848
109MAP2K20.38593423
110LYN0.38243699
111MAPKAPK50.37724061
112SYK0.36116922
113ABL20.35947511
114ZAK0.35875239
115ERN10.35833618
116DAPK30.35830751
117CDK10.35777226
118MAPKAPK30.34128094
119MAP2K70.33695396
120PTK20.33603740
121CLK10.32277491
122MAP2K60.31627640
123FES0.30457567
124MTOR0.30397870
125LIMK10.29349733
126CDK11A0.28183624
127CAMK10.26340827
128ATM0.25879254
129MAP3K50.25590649
130EEF2K0.25566429
131PRKD30.25358703
132CDK150.22676914
133CDK140.18940867
134CDK180.18638685

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.99166482
2Ribosome_Homo sapiens_hsa030104.61653750
3Proteasome_Homo sapiens_hsa030504.10556467
4RNA polymerase_Homo sapiens_hsa030204.08203993
5Mismatch repair_Homo sapiens_hsa034303.92298028
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.66176721
7Spliceosome_Homo sapiens_hsa030403.11826732
8Pyrimidine metabolism_Homo sapiens_hsa002403.01397915
9Base excision repair_Homo sapiens_hsa034103.00319760
10Nucleotide excision repair_Homo sapiens_hsa034202.73612387
11Homologous recombination_Homo sapiens_hsa034402.64414925
12RNA transport_Homo sapiens_hsa030132.60198970
13One carbon pool by folate_Homo sapiens_hsa006702.39130361
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29773788
15Cell cycle_Homo sapiens_hsa041101.93743021
16Protein export_Homo sapiens_hsa030601.79084313
17Fanconi anemia pathway_Homo sapiens_hsa034601.74761841
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71174031
19Basal transcription factors_Homo sapiens_hsa030221.67555074
20RNA degradation_Homo sapiens_hsa030181.65605952
21Purine metabolism_Homo sapiens_hsa002301.65271822
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63142864
23Sulfur relay system_Homo sapiens_hsa041221.60085783
24Non-homologous end-joining_Homo sapiens_hsa034501.55284701
25Parkinsons disease_Homo sapiens_hsa050121.45287851
26Oxidative phosphorylation_Homo sapiens_hsa001901.43507934
27Folate biosynthesis_Homo sapiens_hsa007901.23919113
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18256672
29Huntingtons disease_Homo sapiens_hsa050161.15564354
30p53 signaling pathway_Homo sapiens_hsa041151.15488620
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10548833
32Fatty acid elongation_Homo sapiens_hsa000621.08235100
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06613823
34Pyruvate metabolism_Homo sapiens_hsa006201.04839963
35Pentose phosphate pathway_Homo sapiens_hsa000301.04319418
36Epstein-Barr virus infection_Homo sapiens_hsa051691.03493215
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.02993127
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.01933750
39mRNA surveillance pathway_Homo sapiens_hsa030150.95603646
40N-Glycan biosynthesis_Homo sapiens_hsa005100.92851269
41Biosynthesis of amino acids_Homo sapiens_hsa012300.86713063
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.77714012
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72951475
44Steroid biosynthesis_Homo sapiens_hsa001000.68697739
45Alzheimers disease_Homo sapiens_hsa050100.63401499
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63097158
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63042478
48Thyroid cancer_Homo sapiens_hsa052160.57544843
49Sulfur metabolism_Homo sapiens_hsa009200.57511895
50Herpes simplex infection_Homo sapiens_hsa051680.57107585
51Primary immunodeficiency_Homo sapiens_hsa053400.53834901
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53620322
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53506257
54Vibrio cholerae infection_Homo sapiens_hsa051100.53058391
55Antigen processing and presentation_Homo sapiens_hsa046120.52953709
56Vitamin B6 metabolism_Homo sapiens_hsa007500.51551942
57Shigellosis_Homo sapiens_hsa051310.51252522
58Fructose and mannose metabolism_Homo sapiens_hsa000510.51059921
59Metabolic pathways_Homo sapiens_hsa011000.50745031
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50093854
61Legionellosis_Homo sapiens_hsa051340.48433391
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48343926
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47888150
64Glutathione metabolism_Homo sapiens_hsa004800.46521660
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45484128
66Galactose metabolism_Homo sapiens_hsa000520.45090466
67Basal cell carcinoma_Homo sapiens_hsa052170.42842578
68Oocyte meiosis_Homo sapiens_hsa041140.42801925
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38197932
70Viral carcinogenesis_Homo sapiens_hsa052030.38111027
71HTLV-I infection_Homo sapiens_hsa051660.38103038
72Carbon metabolism_Homo sapiens_hsa012000.38054556
73Systemic lupus erythematosus_Homo sapiens_hsa053220.36505922
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35792082
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32956478
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32815459
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32808385
78Other glycan degradation_Homo sapiens_hsa005110.32757325
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.32226218
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31828189
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31727561
82Phenylalanine metabolism_Homo sapiens_hsa003600.31683341
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31064375
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31043578
85Selenocompound metabolism_Homo sapiens_hsa004500.29259961
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29071610
87Regulation of autophagy_Homo sapiens_hsa041400.28257963
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26669812
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24840773
90Acute myeloid leukemia_Homo sapiens_hsa052210.24119336
91Apoptosis_Homo sapiens_hsa042100.23475074
92Arachidonic acid metabolism_Homo sapiens_hsa005900.22562330
93Colorectal cancer_Homo sapiens_hsa052100.19625739
94Hematopoietic cell lineage_Homo sapiens_hsa046400.18890881
95Tyrosine metabolism_Homo sapiens_hsa003500.18473531
96Collecting duct acid secretion_Homo sapiens_hsa049660.18337498
97Measles_Homo sapiens_hsa051620.17769078
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17390569
99Hedgehog signaling pathway_Homo sapiens_hsa043400.16710319
100Hippo signaling pathway_Homo sapiens_hsa043900.16255100
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15705562
102Lysine degradation_Homo sapiens_hsa003100.15235176
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15046293
104Alcoholism_Homo sapiens_hsa050340.14582104
105Arginine and proline metabolism_Homo sapiens_hsa003300.14150030
106Renin-angiotensin system_Homo sapiens_hsa046140.14139237
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13302440
108Hepatitis B_Homo sapiens_hsa051610.11773626
109Fatty acid metabolism_Homo sapiens_hsa012120.10965664
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.09956957
111Small cell lung cancer_Homo sapiens_hsa052220.09094210
112Bladder cancer_Homo sapiens_hsa052190.08913498
113HIF-1 signaling pathway_Homo sapiens_hsa040660.08581996
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.06379690
115Sphingolipid metabolism_Homo sapiens_hsa006000.05841109
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05283253
117Cardiac muscle contraction_Homo sapiens_hsa042600.05263650
118Vitamin digestion and absorption_Homo sapiens_hsa049770.04642773
119Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0196748
120Influenza A_Homo sapiens_hsa05164-0.0055901
121Allograft rejection_Homo sapiens_hsa05330-0.0054347
122Asthma_Homo sapiens_hsa05310-0.0022245

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