PVALB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)9.67822280
2skeletal muscle contraction (GO:0003009)9.39128110
3sarcoplasmic reticulum calcium ion transport (GO:0070296)9.37771313
4skeletal muscle adaptation (GO:0043501)8.75083435
5actin-mediated cell contraction (GO:0070252)8.48872372
6skeletal muscle fiber development (GO:0048741)7.38966191
7cerebellar Purkinje cell differentiation (GO:0021702)7.23543247
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.08010748
9cerebellar Purkinje cell layer development (GO:0021680)6.84105089
10neuronal action potential propagation (GO:0019227)6.77171263
11gamma-aminobutyric acid signaling pathway (GO:0007214)6.50983092
12actin filament-based movement (GO:0030048)6.36128991
13myotube cell development (GO:0014904)6.29346940
14fructose metabolic process (GO:0006000)6.28131686
15glycogen catabolic process (GO:0005980)6.14854099
16cell differentiation in hindbrain (GO:0021533)6.14174644
17C4-dicarboxylate transport (GO:0015740)6.09777436
18striated muscle contraction (GO:0006941)5.95640139
19protein heterotetramerization (GO:0051290)5.90224886
20ionotropic glutamate receptor signaling pathway (GO:0035235)5.89147841
21metanephric nephron tubule development (GO:0072234)5.84899793
22metanephric tubule development (GO:0072170)5.84899793
23prepulse inhibition (GO:0060134)5.82444764
24plasma membrane repair (GO:0001778)5.81630387
25positive regulation of synaptic transmission, GABAergic (GO:0032230)5.80851690
26regulation of cell communication by electrical coupling (GO:0010649)5.79461038
27cellular sodium ion homeostasis (GO:0006883)5.75704987
28glucan catabolic process (GO:0009251)5.75032493
29creatine metabolic process (GO:0006600)5.73702612
30regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.72881063
31sodium ion export (GO:0071436)5.70148443
32regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.57471249
33metanephric nephron epithelium development (GO:0072243)5.46119789
34response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.44950466
35cellular polysaccharide catabolic process (GO:0044247)5.32695631
36collecting duct development (GO:0072044)5.31620870
37neurofilament cytoskeleton organization (GO:0060052)5.30555111
38response to histamine (GO:0034776)5.29416714
39neuron-neuron synaptic transmission (GO:0007270)5.28767715
40positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.23668391
41positive regulation of cardiac muscle hypertrophy (GO:0010613)5.21748217
42positive regulation of muscle hypertrophy (GO:0014742)5.21748217
43glutamate receptor signaling pathway (GO:0007215)5.17920130
44skeletal muscle tissue regeneration (GO:0043403)5.16165727
45sarcomere organization (GO:0045214)5.12923024
46polysaccharide catabolic process (GO:0000272)5.09367497
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)5.02162638
48purine nucleotide salvage (GO:0032261)5.00929015
49striated muscle atrophy (GO:0014891)5.00381726
50metanephric epithelium development (GO:0072207)5.00257685
51musculoskeletal movement (GO:0050881)4.96994052
52multicellular organismal movement (GO:0050879)4.96994052
53response to muscle activity (GO:0014850)4.93234894
54synaptic transmission, glutamatergic (GO:0035249)4.92753496
55carnitine shuttle (GO:0006853)4.89581524
56inositol phosphate-mediated signaling (GO:0048016)4.89542387
57pyrimidine ribonucleoside catabolic process (GO:0046133)4.89487456
58muscle contraction (GO:0006936)4.83126783
59relaxation of smooth muscle (GO:0044557)4.81855919
60aggressive behavior (GO:0002118)4.77295265
61response to inactivity (GO:0014854)4.71455039
62myofibril assembly (GO:0030239)4.68898141
63striated muscle adaptation (GO:0014888)4.61223390
64positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.55666824
65neuromuscular synaptic transmission (GO:0007274)4.53666242
66cytidine metabolic process (GO:0046087)4.50027516
67cytidine catabolic process (GO:0006216)4.50027516
68cytidine deamination (GO:0009972)4.50027516
69glucan biosynthetic process (GO:0009250)4.48429300
70glycogen biosynthetic process (GO:0005978)4.48429300
71muscle fiber development (GO:0048747)4.44124754
72retina layer formation (GO:0010842)4.41158241
73muscle atrophy (GO:0014889)4.37398105
74negative regulation of heart rate (GO:0010459)4.36000998
75muscle system process (GO:0003012)4.32265942
76positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.26058650
77regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.25712099
78negative regulation of norepinephrine secretion (GO:0010700)4.16856806
79positive regulation of dendritic spine morphogenesis (GO:0061003)4.15277157
80glycogen metabolic process (GO:0005977)4.08037655
81regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.07840088
82behavioral response to nicotine (GO:0035095)4.07312028
83fatty acid transmembrane transport (GO:1902001)4.04961302
84chemosensory behavior (GO:0007635)4.04462713
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.00815594
86cellular glucan metabolic process (GO:0006073)3.99642104
87glucan metabolic process (GO:0044042)3.99642104
88negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.98313837
89IMP metabolic process (GO:0046040)3.98123502
90relaxation of cardiac muscle (GO:0055119)3.92902624
91regulation of skeletal muscle cell differentiation (GO:2001014)3.90413710
92regulation of acyl-CoA biosynthetic process (GO:0050812)3.90291145
93cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.90094059
94regulation of potassium ion transmembrane transporter activity (GO:1901016)3.88990443
95potassium ion homeostasis (GO:0055075)3.88229320
96retinal cone cell development (GO:0046549)3.85525139
97relaxation of muscle (GO:0090075)3.85203216
98regulation of calcium ion transmembrane transporter activity (GO:1901019)3.81464806
99regulation of calcium ion transmembrane transport (GO:1903169)3.81464806
100carnitine transmembrane transport (GO:1902603)3.78236675
101synaptic vesicle exocytosis (GO:0016079)3.77249169
102positive regulation of glomerulus development (GO:0090193)3.76234871
103cardiac muscle contraction (GO:0060048)3.75740130
104actomyosin structure organization (GO:0031032)3.74933118
105regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.70072463
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69816809
107positive regulation of amino acid transport (GO:0051957)3.69411712
108muscle adaptation (GO:0043500)3.69138410
109endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.66839536
110tricarboxylic acid cycle (GO:0006099)3.61211150
111positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.59870821
112negative regulation of muscle hypertrophy (GO:0014741)3.56882574
113auditory receptor cell stereocilium organization (GO:0060088)3.56215287
114regulation of cofactor metabolic process (GO:0051193)3.55883216
115regulation of coenzyme metabolic process (GO:0051196)3.55883216
116regulation of potassium ion transmembrane transport (GO:1901379)3.54620253
117innervation (GO:0060384)3.53943015
118muscle cell cellular homeostasis (GO:0046716)3.53098106
119layer formation in cerebral cortex (GO:0021819)3.51992719
120regulation of excitatory postsynaptic membrane potential (GO:0060079)3.51916645
121negative regulation of skeletal muscle tissue development (GO:0048642)3.51728135
122long-term memory (GO:0007616)3.51391113
123membrane depolarization during action potential (GO:0086010)3.50796563
124long term synaptic depression (GO:0060292)3.50527718
125neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.49577354
126negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.46807782
127carnitine transport (GO:0015879)3.45806460
128amino-acid betaine transport (GO:0015838)3.45806460
129positive regulation of potassium ion transmembrane transport (GO:1901381)3.45421125
130serotonin metabolic process (GO:0042428)3.43253140
131neuromuscular junction development (GO:0007528)3.41936314
132transmission of nerve impulse (GO:0019226)3.40291199
133dopamine biosynthetic process (GO:0042416)3.39256636
134cellular carbohydrate catabolic process (GO:0044275)3.39053402
135NADH metabolic process (GO:0006734)3.37338430
136response to activity (GO:0014823)3.35978671
137cGMP metabolic process (GO:0046068)3.34790649
138potassium ion import (GO:0010107)3.33974346
139acidic amino acid transport (GO:0015800)3.33844115
140succinate metabolic process (GO:0006105)3.32149866
141nephron tubule development (GO:0072080)3.30768858
142myotube differentiation (GO:0014902)3.29609524
143behavioral response to cocaine (GO:0048148)3.27837365
144response to water (GO:0009415)3.26386936
145mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.26064730
146parturition (GO:0007567)3.25199233
147regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23210621
148regulation of postsynaptic membrane potential (GO:0060078)3.21774863
149cell communication by electrical coupling (GO:0010644)3.20289757
150sodium ion homeostasis (GO:0055078)3.17767085
151regulation of striated muscle contraction (GO:0006942)3.17176797
152regulation of actin filament-based movement (GO:1903115)3.16953970
153negative regulation of fatty acid transport (GO:2000192)3.16587264
154muscle organ development (GO:0007517)3.16256997
155synaptic vesicle maturation (GO:0016188)3.13572553
156response to ammonium ion (GO:0060359)3.13031234
157negative regulation of heart contraction (GO:0045822)3.12634962
158regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.11411437
159regulation of dopamine secretion (GO:0014059)3.11163259
160muscle structure development (GO:0061061)3.11107364
161membrane depolarization (GO:0051899)3.09191708
162striated muscle cell development (GO:0055002)3.08738904
163detection of calcium ion (GO:0005513)3.07703415
164regulation of amine transport (GO:0051952)3.06526403
165adult walking behavior (GO:0007628)3.05891946
166cellular potassium ion homeostasis (GO:0030007)3.04764813
167L-glutamate transport (GO:0015813)3.04240616
168negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.02294551
169regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.01939955
170negative regulation of catecholamine secretion (GO:0033604)3.01268382
171exploration behavior (GO:0035640)2.98421852
172endocrine hormone secretion (GO:0060986)2.98279329
173regulation of membrane repolarization (GO:0060306)2.98124698
174regulation of relaxation of muscle (GO:1901077)2.97798951
175negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.97138004
176positive regulation of cation channel activity (GO:2001259)2.96394669
177primary amino compound metabolic process (GO:1901160)2.94325635
178cellular response to ammonium ion (GO:0071242)2.93966897
179regulation of cation channel activity (GO:2001257)2.93750362
180regulation of neurotransmitter secretion (GO:0046928)2.93701168
181activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.93434708
182cellular response to dexamethasone stimulus (GO:0071549)2.91843740
183endoplasmic reticulum organization (GO:0007029)2.91235556
184IMP biosynthetic process (GO:0006188)2.90133610
185cerebellar granule cell differentiation (GO:0021707)2.87829119
186skeletal muscle tissue development (GO:0007519)2.86213409
187regulation of sequestering of calcium ion (GO:0051282)2.82899151
188regulation of sulfur metabolic process (GO:0042762)2.82675661
189calcium ion import (GO:0070509)2.82406863
190regulation of skeletal muscle contraction (GO:0014819)10.6675693
191actin-myosin filament sliding (GO:0033275)10.4402085
192muscle filament sliding (GO:0030049)10.4402085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.49572450
2GBX2_23144817_ChIP-Seq_PC3_Human4.31244835
3EZH2_22144423_ChIP-Seq_EOC_Human4.03068629
4TAF15_26573619_Chip-Seq_HEK293_Human3.97654316
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.94948552
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.91966836
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79657325
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.53918189
9AR_21572438_ChIP-Seq_LNCaP_Human2.52551817
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.49922159
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.46189717
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.41262213
13SRY_22984422_ChIP-ChIP_TESTIS_Rat2.35308088
14* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.34839513
15DROSHA_22980978_ChIP-Seq_HELA_Human2.24153945
16SMAD4_21799915_ChIP-Seq_A2780_Human2.20766239
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.16587681
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11071183
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09438573
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.04082731
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03185174
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02294629
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02294629
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00434582
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98658770
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98598964
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93660098
28CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93211577
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93175281
30ZNF274_21170338_ChIP-Seq_K562_Hela1.90186527
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89422331
32FUS_26573619_Chip-Seq_HEK293_Human1.88581203
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87327430
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85849604
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85577607
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85387195
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82437371
38* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82303547
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.80651658
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77874766
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.72425040
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72171560
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68792864
44ZNF263_19887448_ChIP-Seq_K562_Human1.68463719
45TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67202207
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.60974150
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.59714192
48TBX20_22080862_ChIP-Seq_HEART_Mouse1.59714192
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57905640
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56933321
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.55471196
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54884214
53HTT_18923047_ChIP-ChIP_STHdh_Human1.54802771
54BCAT_22108803_ChIP-Seq_LS180_Human1.54762349
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53639213
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48553112
57CTCF_27219007_Chip-Seq_Bcells_Human1.47129582
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.42564282
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40920228
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.40233794
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.39826264
62TCF4_23295773_ChIP-Seq_U87_Human1.39612919
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38753683
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38724062
65P300_19829295_ChIP-Seq_ESCs_Human1.36898799
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.33270853
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.29068419
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26198967
69REST_21632747_ChIP-Seq_MESCs_Mouse1.24395124
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23452890
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.23038345
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22918470
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22464209
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21793201
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21584289
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20713667
77ELK4_26923725_Chip-Seq_MESODERM_Mouse1.20399145
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19103317
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17757201
80CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17090026
81CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17069233
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.16025059
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14693956
84STAT3_23295773_ChIP-Seq_U87_Human1.14486486
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13983201
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13921451
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.13805009
88KDM2B_26808549_Chip-Seq_K562_Human1.13628744
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12686047
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11928212
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10617753
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09740852
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.08928112
94* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08436773
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.08432240
96SA1_27219007_Chip-Seq_Bcells_Human1.08157806
97FOXH1_21741376_ChIP-Seq_ESCs_Human1.06645207
98TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04612873
99EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03998690
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03616547
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.01243884
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.00780987
103CBP_20019798_ChIP-Seq_JUKART_Human1.00589970
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00589970
105RXR_22108803_ChIP-Seq_LS180_Human1.00198653
106* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00037583
107WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99498420
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99334601
109KLF4_19829295_ChIP-Seq_ESCs_Human0.99306146
110MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98440590
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97252300
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96980577
113* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96557068
114JUN_21703547_ChIP-Seq_K562_Human0.95238808
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94581475
116AR_25329375_ChIP-Seq_VCAP_Human0.94013977
117TP53_18474530_ChIP-ChIP_U2OS_Human0.93716389
118MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93461183
119KDM2B_26808549_Chip-Seq_DND41_Human0.93302873
120OCT1_27270436_Chip-Seq_PROSTATE_Human0.92794008
121AR_19668381_ChIP-Seq_PC3_Human0.92292004
122FLI1_21867929_ChIP-Seq_TH2_Mouse0.92143758
123TAL1_26923725_Chip-Seq_HPCs_Mouse0.92057926
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.91134656
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90908067
126LXR_22292898_ChIP-Seq_THP-1_Human0.90382846
127* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89635726
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89381678
129KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89339369
130MYC_27129775_Chip-Seq_CORNEA_Mouse0.89195536
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88762697
132CREB1_26743006_Chip-Seq_LNCaP_Human0.88491200
133YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87624039
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87365674
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87312304
136RUNX2_22187159_ChIP-Seq_PCA_Human0.86686135
137OCT4_20526341_ChIP-Seq_ESCs_Human0.86587952
138GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.86399569
139VDR_22108803_ChIP-Seq_LS180_Human0.86225146
140CBX2_27304074_Chip-Seq_ESCs_Mouse0.85868391
141RNF2_27304074_Chip-Seq_NSC_Mouse0.85214603
142SALL4_22934838_ChIP-ChIP_CD34+_Human0.84772316
143TCF4_22108803_ChIP-Seq_LS180_Human0.84581965
144SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82164597
145LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.82160119
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80962163
147SMAD4_21741376_ChIP-Seq_ESCs_Human0.80900404
148P68_20966046_ChIP-Seq_HELA_Human0.80031518
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79496141
150NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79496141
151OCT4_19829295_ChIP-Seq_ESCs_Human0.79180271
152SMC1_22415368_ChIP-Seq_MEFs_Mouse0.79076890
153KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78658055
154KLF5_20875108_ChIP-Seq_MESCs_Mouse0.78462245
155ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77709049
156RING1B_27294783_Chip-Seq_ESCs_Mouse0.76801597
157FOXH1_21741376_ChIP-Seq_EPCs_Human0.76727463
158P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76435745
159SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76048121
160MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.75648032
161SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75460832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio8.42253578
2MP0003646_muscle_fatigue6.04940879
3MP0000749_muscle_degeneration5.84622971
4MP0000751_myopathy5.27360722
5MP0004742_abnormal_vestibular_system5.19497255
6MP0010386_abnormal_urinary_bladder4.47477599
7MP0000747_muscle_weakness4.31089698
8MP0004036_abnormal_muscle_relaxation3.95141673
9MP0002106_abnormal_muscle_physiology3.94222710
10MP0000759_abnormal_skeletal_muscle3.55108708
11MP0001984_abnormal_olfaction3.35300223
12MP0005369_muscle_phenotype3.31581968
13MP0002269_muscular_atrophy3.26092661
14MP0002837_dystrophic_cardiac_calcinosis3.15752963
15MP0004130_abnormal_muscle_cell3.11643263
16MP0001968_abnormal_touch/_nociception3.06549254
17MP0004087_abnormal_muscle_fiber3.05861097
18* MP0005620_abnormal_muscle_contractility2.80393848
19MP0000750_abnormal_muscle_regeneration2.66762807
20MP0002638_abnormal_pupillary_reflex2.66346144
21MP0004233_abnormal_muscle_weight2.64466496
22MP0008875_abnormal_xenobiotic_pharmacok2.41116699
23MP0002332_abnormal_exercise_endurance2.20507489
24MP0002735_abnormal_chemical_nociception2.20096680
25MP0005423_abnormal_somatic_nervous2.17018000
26MP0004270_analgesia2.16306549
27MP0008874_decreased_physiological_sensi2.14434046
28MP0002108_abnormal_muscle_morphology1.92527643
29MP0000733_abnormal_muscle_development1.91719880
30MP0004859_abnormal_synaptic_plasticity1.87857994
31MP0006036_abnormal_mitochondrial_physio1.83658481
32MP0002736_abnormal_nociception_after1.70480644
33MP0001970_abnormal_pain_threshold1.67329282
34MP0006276_abnormal_autonomic_nervous1.62739417
35MP0009046_muscle_twitch1.55532197
36MP0008569_lethality_at_weaning1.54626386
37MP0008872_abnormal_physiological_respon1.52019042
38MP0005330_cardiomyopathy1.48402630
39MP0003011_delayed_dark_adaptation1.48181466
40MP0002557_abnormal_social/conspecific_i1.44318007
41MP0004215_abnormal_myocardial_fiber1.43605830
42MP0003787_abnormal_imprinting1.43301606
43MP0004147_increased_porphyrin_level1.41195076
44MP0004084_abnormal_cardiac_muscle1.39807177
45MP0000013_abnormal_adipose_tissue1.37385581
46MP0004185_abnormal_adipocyte_glucose1.36615452
47MP0004484_altered_response_of1.29060153
48MP0002971_abnormal_brown_adipose1.27439604
49MP0002733_abnormal_thermal_nociception1.23475220
50MP0000566_synostosis1.19998461
51MP0005410_abnormal_fertilization1.19087438
52MP0000920_abnormal_myelination1.14991681
53MP0003635_abnormal_synaptic_transmissio1.14178741
54MP0002229_neurodegeneration1.13461794
55MP0002972_abnormal_cardiac_muscle1.12024453
56MP0005666_abnormal_adipose_tissue1.10113838
57MP0004142_abnormal_muscle_tone1.08743171
58MP0004043_abnormal_pH_regulation1.06886158
59MP0001485_abnormal_pinna_reflex1.06255533
60* MP0002882_abnormal_neuron_morphology1.05005312
61MP0003122_maternal_imprinting0.97966855
62MP0005266_abnormal_metabolism0.94599314
63MP0002272_abnormal_nervous_system0.93851578
64MP0003137_abnormal_impulse_conducting0.88326091
65MP0005551_abnormal_eye_electrophysiolog0.87999242
66MP0002067_abnormal_sensory_capabilities0.87401024
67MP0002734_abnormal_mechanical_nocicepti0.87233454
68MP0001440_abnormal_grooming_behavior0.86243496
69MP0001299_abnormal_eye_distance/0.86096574
70MP0005375_adipose_tissue_phenotype0.86094041
71MP0005275_abnormal_skin_tensile0.85882119
72MP0003221_abnormal_cardiomyocyte_apopto0.85140665
73MP0003656_abnormal_erythrocyte_physiolo0.84877966
74MP0006072_abnormal_retinal_apoptosis0.83420088
75MP0010630_abnormal_cardiac_muscle0.83388496
76MP0000569_abnormal_digit_pigmentation0.83209394
77MP0009745_abnormal_behavioral_response0.83059885
78MP0002064_seizures0.81255506
79MP0008877_abnormal_DNA_methylation0.78592305
80MP0000343_altered_response_to0.77709341
81MP0004134_abnormal_chest_morphology0.77668814
82MP0001188_hyperpigmentation0.76705981
83MP0003705_abnormal_hypodermis_morpholog0.76393689
84MP0005623_abnormal_meninges_morphology0.76105921
85MP0009697_abnormal_copulation0.75242767
86MP0001502_abnormal_circadian_rhythm0.75163021
87MP0001765_abnormal_ion_homeostasis0.74891974
88MP0000372_irregular_coat_pigmentation0.72801161
89MP0003806_abnormal_nucleotide_metabolis0.72498940
90MP0005083_abnormal_biliary_tract0.70406433
91MP0002277_abnormal_respiratory_mucosa0.68954226
92MP0002066_abnormal_motor_capabilities/c0.68838648
93MP0003123_paternal_imprinting0.68406414
94* MP0002152_abnormal_brain_morphology0.67737635
95MP0008961_abnormal_basal_metabolism0.67635782
96MP0000230_abnormal_systemic_arterial0.67286574
97MP0002089_abnormal_postnatal_growth/wei0.67219320
98MP0005595_abnormal_vascular_smooth0.65946773
99MP0001544_abnormal_cardiovascular_syste0.65521942
100MP0005385_cardiovascular_system_phenoty0.65521942
101MP0002063_abnormal_learning/memory/cond0.65472574
102MP0005646_abnormal_pituitary_gland0.62950171
103MP0009379_abnormal_foot_pigmentation0.61421369
104MP0000003_abnormal_adipose_tissue0.60308661
105MP0001963_abnormal_hearing_physiology0.58942296
106MP0002234_abnormal_pharynx_morphology0.57769268
107MP0009250_abnormal_appendicular_skeleto0.57483732
108MP0003329_amyloid_beta_deposits0.56897054
109* MP0006035_abnormal_mitochondrial_morpho0.56597375
110MP0003868_abnormal_feces_composition0.56557477
111MP0002184_abnormal_innervation0.56403757
112MP0002078_abnormal_glucose_homeostasis0.55945885
113MP0002090_abnormal_vision0.54633506
114MP0000534_abnormal_ureter_morphology0.52847834
115MP0003950_abnormal_plasma_membrane0.52475925
116MP0005584_abnormal_enzyme/coenzyme_acti0.52071199
117MP0001986_abnormal_taste_sensitivity0.51807485
118MP0001501_abnormal_sleep_pattern0.50642263
119MP0000955_abnormal_spinal_cord0.49491649
120MP0001756_abnormal_urination0.49397905
121MP0010329_abnormal_lipoprotein_level0.49345317
122MP0001486_abnormal_startle_reflex0.49084751
123MP0002752_abnormal_somatic_nervous0.48289962
124MP0003045_fibrosis0.47757657
125MP0002083_premature_death0.46747386
126MP0000762_abnormal_tongue_morphology0.46461585
127MP0003956_abnormal_body_size0.46371452
128MP0000579_abnormal_nail_morphology0.45521065
129MP0005464_abnormal_platelet_physiology0.45505907
130MP0005334_abnormal_fat_pad0.45385071
131MP0003638_abnormal_response/metabolism_0.44791172
132MP0003879_abnormal_hair_cell0.44481188
133MP0002909_abnormal_adrenal_gland0.44428559
134MP0001177_atelectasis0.44419865
135MP0004858_abnormal_nervous_system0.44369208
136MP0000538_abnormal_urinary_bladder0.43400143
137MP0008775_abnormal_heart_ventricle0.43258955
138MP0005253_abnormal_eye_physiology0.43045122
139MP0005174_abnormal_tail_pigmentation0.42775627
140MP0005452_abnormal_adipose_tissue0.42251652
141MP0003633_abnormal_nervous_system0.41523025
142MP0009780_abnormal_chondrocyte_physiolo0.40972977
143MP0002572_abnormal_emotion/affect_behav0.40493283
144MP0002822_catalepsy0.40174264
145MP0005535_abnormal_body_temperature0.39849831
146MP0004085_abnormal_heartbeat0.38743330
147MP0002896_abnormal_bone_mineralization0.37584293
148MP0001943_abnormal_respiration0.36875842
149MP0002796_impaired_skin_barrier0.36262965
150MP0003880_abnormal_central_pattern0.35329101
151MP0004811_abnormal_neuron_physiology0.34913249
152MP0004924_abnormal_behavior0.33762362
153MP0005386_behavior/neurological_phenoty0.33762362
154MP0006138_congestive_heart_failure0.33640366
155MP0003631_nervous_system_phenotype0.33493920
156MP0003959_abnormal_lean_body0.33096577
157MP0000266_abnormal_heart_morphology0.32693947

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)8.98589486
2Muscle fiber inclusion bodies (HP:0100299)8.93977815
3Exercise-induced myalgia (HP:0003738)8.93960058
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.66518634
5Scanning speech (HP:0002168)8.60180968
6Myokymia (HP:0002411)8.36754499
7Exercise-induced muscle cramps (HP:0003710)8.25564007
8Dysmetric saccades (HP:0000641)8.25332569
9Nemaline bodies (HP:0003798)8.13692975
10Distal arthrogryposis (HP:0005684)7.05983354
11Muscle hypertrophy of the lower extremities (HP:0008968)6.65997221
12Myopathic facies (HP:0002058)6.58233115
13Type 1 muscle fiber predominance (HP:0003803)6.56813885
14Dysdiadochokinesis (HP:0002075)6.49135429
15Progressive cerebellar ataxia (HP:0002073)6.40723258
16Epileptic encephalopathy (HP:0200134)6.38851144
17Round ear (HP:0100830)6.34637186
18Horizontal nystagmus (HP:0000666)6.18563444
19Ulnar deviation of the wrist (HP:0003049)6.17267753
20Dialeptic seizures (HP:0011146)5.98604210
21Gaze-evoked nystagmus (HP:0000640)5.75507977
22Postural tremor (HP:0002174)5.74933182
23Calf muscle hypertrophy (HP:0008981)5.72620607
24Difficulty running (HP:0009046)5.37232047
25Myoglobinuria (HP:0002913)5.29331882
26Calcaneovalgus deformity (HP:0001848)5.29207529
27Intention tremor (HP:0002080)5.16530969
28Truncal ataxia (HP:0002078)5.13488752
29Focal seizures (HP:0007359)5.13401127
30Absent phalangeal crease (HP:0006109)5.02465685
31Muscle stiffness (HP:0003552)4.98023221
32Deformed tarsal bones (HP:0008119)4.96271428
33Impaired vibration sensation in the lower limbs (HP:0002166)4.84402584
34Dysmetria (HP:0001310)4.77182397
35Muscle fiber splitting (HP:0003555)4.76430027
36Myotonia (HP:0002486)4.54113084
37Hyporeflexia of lower limbs (HP:0002600)4.47835063
38Impaired smooth pursuit (HP:0007772)4.41677990
39Abnormal finger flexion creases (HP:0006143)4.28161080
40EMG: myopathic abnormalities (HP:0003458)4.28158153
41Rhabdomyolysis (HP:0003201)4.26941345
42Increased connective tissue (HP:0009025)4.05729975
43Abnormality of saccadic eye movements (HP:0000570)3.89337500
44Abnormality of the calf musculature (HP:0001430)3.78371237
45Abnormality of skeletal muscle fiber size (HP:0012084)3.74176839
46Degeneration of the lateral corticospinal tracts (HP:0002314)3.74123909
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.74123909
48Abnormality of ocular smooth pursuit (HP:0000617)3.73135196
49Generalized tonic-clonic seizures (HP:0002069)3.54307200
50Increased variability in muscle fiber diameter (HP:0003557)3.40332369
51Abnormality of the left ventricular outflow tract (HP:0011103)3.39965488
52Subaortic stenosis (HP:0001682)3.39965488
53Acute necrotizing encephalopathy (HP:0006965)3.37162088
54Shoulder girdle muscle weakness (HP:0003547)3.28352521
55Malignant hyperthermia (HP:0002047)3.27306252
56Neck muscle weakness (HP:0000467)3.25287790
57Limb ataxia (HP:0002070)3.22614738
58Rimmed vacuoles (HP:0003805)3.16378559
59Pelvic girdle muscle weakness (HP:0003749)3.15708758
60Abnormality of the corticospinal tract (HP:0002492)3.09517356
61Abnormality of the calcaneus (HP:0008364)3.08338512
62Abnormality of the hip-girdle musculature (HP:0001445)3.07996171
63Abnormality of the musculature of the pelvis (HP:0001469)3.07996171
64Abnormal mitochondria in muscle tissue (HP:0008316)3.05181517
65Difficulty climbing stairs (HP:0003551)3.04634932
66Hyperlipoproteinemia (HP:0010980)3.04338370
67Frequent falls (HP:0002359)2.99669116
68Hyperkalemia (HP:0002153)2.97519473
69Impaired vibratory sensation (HP:0002495)2.93726177
70Areflexia of lower limbs (HP:0002522)2.93523930
71Progressive macrocephaly (HP:0004481)2.91647108
72Gait ataxia (HP:0002066)2.80401013
73Status epilepticus (HP:0002133)2.71306320
74Asymmetric septal hypertrophy (HP:0001670)2.66465140
75Focal dystonia (HP:0004373)2.65739571
76Acute encephalopathy (HP:0006846)2.65663168
77Paralysis (HP:0003470)2.54277289
78EMG: neuropathic changes (HP:0003445)2.47587552
79Sudden death (HP:0001699)2.47060724
80Slender build (HP:0001533)2.46423275
81Mitochondrial inheritance (HP:0001427)2.44158110
82Nonprogressive disorder (HP:0003680)2.41056268
83Fatigable weakness (HP:0003473)2.35748435
84Abnormality of the neuromuscular junction (HP:0003398)2.35748435
85Diplopia (HP:0000651)2.33331135
86Abnormality of binocular vision (HP:0011514)2.33331135
87Depression (HP:0000716)2.31979288
88Autoamputation (HP:0001218)2.29336779
89Focal motor seizures (HP:0011153)2.28427385
90Muscular dystrophy (HP:0003560)2.28237133
91Distal lower limb muscle weakness (HP:0009053)2.22697364
92Insidious onset (HP:0003587)2.15114551
93Termporal pattern (HP:0011008)2.15114551
94Cerebellar atrophy (HP:0001272)2.13762937
95Slow progression (HP:0003677)2.13056908
96Ulnar deviation of finger (HP:0009465)2.11484085
97Limb-girdle muscle weakness (HP:0003325)2.10719074
98Proximal amyotrophy (HP:0007126)2.09514055
99Hemiplegia (HP:0002301)2.07793136
100Achilles tendon contracture (HP:0001771)2.01774208
101Amblyopia (HP:0000646)2.00719760
102Metatarsus adductus (HP:0001840)1.99975213
103Bulbar palsy (HP:0001283)1.99515712
104Mildly elevated creatine phosphokinase (HP:0008180)1.99454355
105Hypoplastic ischia (HP:0003175)1.99145509
106Generalized muscle weakness (HP:0003324)1.98317954
107Atonic seizures (HP:0010819)1.96211210
108Epileptiform EEG discharges (HP:0011182)1.95966359
109Centrally nucleated skeletal muscle fibers (HP:0003687)1.93774281
110Athetosis (HP:0002305)1.93405263
111Increased hepatocellular lipid droplets (HP:0006565)1.92469352
112Abnormality of the shoulder girdle musculature (HP:0001435)1.90733355
113Dysarthria (HP:0001260)1.90709330
114Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89635938
115Facial diplegia (HP:0001349)1.89481569
116Cerebral edema (HP:0002181)1.87297720
117Limb-girdle muscle atrophy (HP:0003797)1.87225776
118Gout (HP:0001997)1.86692239
119Cholelithiasis (HP:0001081)1.85890354
120EEG with generalized epileptiform discharges (HP:0011198)1.85377532
121Fetal akinesia sequence (HP:0001989)1.84905321
122Increased serum pyruvate (HP:0003542)1.83940819
123Abnormality of the Achilles tendon (HP:0005109)1.82972517
124Spinal rigidity (HP:0003306)1.82962940
125Renal Fanconi syndrome (HP:0001994)1.82357726
126Increased CSF lactate (HP:0002490)1.82232852
127Gowers sign (HP:0003391)1.80892689
128Degeneration of anterior horn cells (HP:0002398)1.79167481
129Abnormality of the anterior horn cell (HP:0006802)1.79167481
130Scapular winging (HP:0003691)1.78281542
131Increased purine levels (HP:0004368)1.75827015
132Hyperuricemia (HP:0002149)1.75827015
133Hemiparesis (HP:0001269)1.75463335
134Tarsal synostosis (HP:0008368)1.75180396
135Abnormality of the ischium (HP:0003174)1.74335631
136Oligomenorrhea (HP:0000876)1.74162581
137Visual hallucinations (HP:0002367)1.71856146
138Morphological abnormality of the pyramidal tract (HP:0002062)1.68420150
139Urinary urgency (HP:0000012)1.67126485
140Abnormality of glycolysis (HP:0004366)1.66841915
141Absence seizures (HP:0002121)1.66800450
142Waddling gait (HP:0002515)1.66486117
143Distal lower limb amyotrophy (HP:0008944)1.64679028
144Abnormal gallbladder morphology (HP:0012437)1.63626843
145Leukodystrophy (HP:0002415)1.63316316
146Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.61427937
147Synostosis involving bones of the lower limbs (HP:0009138)1.60818074
148Synostosis involving bones of the feet (HP:0009140)1.60818074
149Broad-based gait (HP:0002136)1.60781593
150Esotropia (HP:0000565)1.59442549
151Abnormality of potassium homeostasis (HP:0011042)1.59158772
152Weak cry (HP:0001612)1.58791565
153Incomplete penetrance (HP:0003829)1.57702511
154Aplasia involving bones of the extremities (HP:0009825)1.56309957
155Aplasia involving bones of the upper limbs (HP:0009823)1.56309957
156Aplasia of the phalanges of the hand (HP:0009802)1.56309957
157Spastic gait (HP:0002064)1.55975920
158Stridor (HP:0010307)1.55832222
159Supranuclear gaze palsy (HP:0000605)1.55824197
160Lipid accumulation in hepatocytes (HP:0006561)1.55548956
161Choroideremia (HP:0001139)1.53576468
162Exercise intolerance (HP:0003546)1.52046388
163Progressive muscle weakness (HP:0003323)1.51621503
164Increased intramyocellular lipid droplets (HP:0012240)1.51492641
165Intellectual disability, mild (HP:0001256)1.47863930
166Increased density of long bones (HP:0006392)1.47591083
167Adducted thumb (HP:0001181)1.47083360
168Heterochromia iridis (HP:0001100)1.46275608
169Congenital hip dislocation (HP:0001374)1.45900792
170Febrile seizures (HP:0002373)1.45874637
171Bundle branch block (HP:0011710)1.45211090
172Respiratory insufficiency due to muscle weakness (HP:0002747)1.44604858
173Syncope (HP:0001279)1.44311276
174X-linked dominant inheritance (HP:0001423)1.42570850
175Urinary bladder sphincter dysfunction (HP:0002839)1.41271280
176Optic disc pallor (HP:0000543)1.37308069
177Epidermoid cyst (HP:0200040)1.34574903
178Skin nodule (HP:0200036)1.32210145
179Anxiety (HP:0000739)1.31066757
180Lower limb amyotrophy (HP:0007210)1.30714426
181Abnormal eating behavior (HP:0100738)1.28240215
182Postural instability (HP:0002172)1.27715628
183Lower limb muscle weakness (HP:0007340)1.27107855
184Rigidity (HP:0002063)1.26612905
185Ankle clonus (HP:0011448)1.25178184
186Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.22695813
187Exertional dyspnea (HP:0002875)1.22534990
188Dysphonia (HP:0001618)1.22362033
189Global brain atrophy (HP:0002283)1.22325930
190Sleep apnea (HP:0010535)1.21374279
191Progressive inability to walk (HP:0002505)1.21264187
192Hypsarrhythmia (HP:0002521)1.21124775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.71665180
2PHKG15.97991986
3PHKG25.97991986
4TTN5.68734358
5NME14.42233663
6MYLK3.15174682
7PIK3CG3.04958718
8MAP2K32.81832128
9ARAF2.64007578
10NEK12.62784952
11PINK12.54321209
12MAP2K42.44394076
13CSNK1G22.20800541
14CSNK1G32.15253079
15CSNK1A1L2.07305666
16MAP3K72.02108357
17PDK31.96581965
18PDK41.96581965
19TTK1.89707867
20MAPK121.71265700
21CSNK1G11.66124201
22TRIB31.65162620
23EPHA41.63214795
24PIK3CA1.62395664
25MAP2K61.58563422
26PRKG21.53450103
27CASK1.51073982
28DAPK11.50940589
29TESK11.42635725
30MAP3K131.35751522
31DMPK1.34252473
32BCKDK1.29302751
33PDK21.29249439
34PAK41.21572741
35RIPK11.12311379
36BRAF1.07375878
37FYN1.01218244
38RIPK40.99004417
39MAP3K40.96955004
40DAPK30.91607674
41CAMKK20.89099375
42PRKAA10.88617426
43MUSK0.87559809
44PRKAA20.87364027
45CAMK2G0.86816110
46PLK20.82226191
47PRKCA0.81393915
48ERBB30.79905899
49NEK90.78090436
50PRKCE0.77504381
51WNK10.76477889
52NTRK30.76374538
53PAK60.75825363
54EIF2AK10.74730304
55KSR20.73648054
56MAPKAPK30.72982838
57TAOK20.71940987
58MAP3K90.70650888
59CSNK1A10.69529927
60CDK190.63779571
61CDK30.63636268
62TAOK10.62256438
63SCYL20.61652405
64PTK60.58806282
65STK240.56040007
66PNCK0.55468047
67MST40.54065796
68SRC0.52958963
69SGK10.52543398
70MINK10.52226624
71LIMK10.51558655
72STK380.51257962
73PRKDC0.50714379
74MAP3K120.50092283
75TRIM280.49318412
76CSNK1D0.49217757
77TRPM70.48521349
78CDK140.47704894
79MOS0.47383015
80MAP3K110.47051374
81FES0.46962354
82MAP3K30.46394762
83RAF10.45456906
84PRKCB0.45154835
85AKT30.44821548
86EPHB10.44267764
87CDK180.43693217
88MAPK110.43104225
89ITK0.42452707
90TAF10.42203267
91AKT20.42108533
92CAMKK10.41440966
93PRKCG0.41374780
94MAP2K70.40202727
95PRKG10.40133688
96CDK150.39962207
97RPS6KA30.39859671
98CAMK1G0.39796961
99MAP3K10.38213393
100CSNK1E0.38117392
101PDK10.37997162
102UHMK10.37775893
103PDPK10.35986398
104PRKACB0.35282516
105STK390.35022003
106PRKACA0.34804891
107SGK30.34087308
108RPS6KB10.33721409
109DAPK20.33334962
110STK110.32745948
111CDK11A0.31593028
112MARK10.29742453
113PAK30.29532184
114MAP3K60.29343473
115KSR10.28333548
116PRKCH0.27477110
117ILK0.26665748
118SIK10.26521270
119BMX0.26330198
120CCNB10.25501357
121SIK30.25065586
122OXSR10.24568193
123CAMK2D0.23706275
124PKN10.22907997
125MARK20.22617165
126CDK50.22323672
127MAP3K50.21654474
128PRKCZ0.20828376
129MAPK70.20757566
130WNK40.20485966
131SGK20.20272305
132MAP2K10.19943353
133TNK20.19675579
134ROCK20.19461041
135RET0.18900068
136CAMK10.18562099
137NTRK20.18378417
138PRKD10.18316210
139CAMK2A0.17777474
140SGK2230.16489402
141SGK4940.16489402
142LATS20.15879279
143PRKACG0.15277567
144ZAK0.14979674
145MAPK100.14037951
146CAMK40.13770060
147CAMK2B0.13295164
148MAPK40.13268196
149PKN20.13189740
150EEF2K0.12831359
151FER0.12808318
152GRK50.12069668

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.61247141
2Cardiac muscle contraction_Homo sapiens_hsa042603.16987218
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.01046330
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.74411452
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.71516165
6Dilated cardiomyopathy_Homo sapiens_hsa054142.50717841
7Oxytocin signaling pathway_Homo sapiens_hsa049212.37573910
8Circadian rhythm_Homo sapiens_hsa047102.21979806
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08160242
10Glucagon signaling pathway_Homo sapiens_hsa049222.03191520
11Calcium signaling pathway_Homo sapiens_hsa040201.99249875
12Starch and sucrose metabolism_Homo sapiens_hsa005001.94512248
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.93320172
14Insulin signaling pathway_Homo sapiens_hsa049101.77226496
15Alzheimers disease_Homo sapiens_hsa050101.74552089
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.71602069
17Parkinsons disease_Homo sapiens_hsa050121.68402940
18Gastric acid secretion_Homo sapiens_hsa049711.68179007
19Oxidative phosphorylation_Homo sapiens_hsa001901.66034324
20Carbon metabolism_Homo sapiens_hsa012001.63544818
21Long-term depression_Homo sapiens_hsa047301.60179197
22Propanoate metabolism_Homo sapiens_hsa006401.57455007
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55027732
24Long-term potentiation_Homo sapiens_hsa047201.52775927
25Insulin resistance_Homo sapiens_hsa049311.51921944
26Nicotine addiction_Homo sapiens_hsa050331.51323945
27GABAergic synapse_Homo sapiens_hsa047271.43681299
28Circadian entrainment_Homo sapiens_hsa047131.41120485
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39351249
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.36886611
31Fructose and mannose metabolism_Homo sapiens_hsa000511.34685941
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.32471483
33Pyruvate metabolism_Homo sapiens_hsa006201.31047676
34GnRH signaling pathway_Homo sapiens_hsa049121.28674701
35AMPK signaling pathway_Homo sapiens_hsa041521.27684151
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27666590
37Thyroid hormone synthesis_Homo sapiens_hsa049181.26542343
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26325384
39Insulin secretion_Homo sapiens_hsa049111.16774425
40Biosynthesis of amino acids_Homo sapiens_hsa012301.15489995
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.15011761
42Galactose metabolism_Homo sapiens_hsa000521.14227910
43Renin secretion_Homo sapiens_hsa049241.12243389
44Synaptic vesicle cycle_Homo sapiens_hsa047211.11090121
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09771542
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09190853
47Glutamatergic synapse_Homo sapiens_hsa047241.05801468
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04395750
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03778855
50Olfactory transduction_Homo sapiens_hsa047400.99760046
51Salivary secretion_Homo sapiens_hsa049700.98260844
52Tight junction_Homo sapiens_hsa045300.96787762
53Cholinergic synapse_Homo sapiens_hsa047250.88455842
54Type II diabetes mellitus_Homo sapiens_hsa049300.87686806
55Dopaminergic synapse_Homo sapiens_hsa047280.87041986
56Morphine addiction_Homo sapiens_hsa050320.84847539
57Huntingtons disease_Homo sapiens_hsa050160.81070722
58Arginine biosynthesis_Homo sapiens_hsa002200.80630664
59Amphetamine addiction_Homo sapiens_hsa050310.80264229
60Renin-angiotensin system_Homo sapiens_hsa046140.79925358
61Arginine and proline metabolism_Homo sapiens_hsa003300.78396181
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77901817
63Pentose phosphate pathway_Homo sapiens_hsa000300.75448954
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74583013
65MAPK signaling pathway_Homo sapiens_hsa040100.74179271
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.73866762
67VEGF signaling pathway_Homo sapiens_hsa043700.72583767
68Cocaine addiction_Homo sapiens_hsa050300.72378140
69African trypanosomiasis_Homo sapiens_hsa051430.72016768
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71580489
71mTOR signaling pathway_Homo sapiens_hsa041500.70697152
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70498146
73Taste transduction_Homo sapiens_hsa047420.70019346
74FoxO signaling pathway_Homo sapiens_hsa040680.69026132
75Pancreatic secretion_Homo sapiens_hsa049720.66926748
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66697663
77Nitrogen metabolism_Homo sapiens_hsa009100.65285478
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65064519
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61377070
80Glycerolipid metabolism_Homo sapiens_hsa005610.60907763
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60425168
82Focal adhesion_Homo sapiens_hsa045100.60035014
83Fatty acid biosynthesis_Homo sapiens_hsa000610.58399846
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.55192468
85Gap junction_Homo sapiens_hsa045400.54942581
86Fatty acid degradation_Homo sapiens_hsa000710.53435187
87Fatty acid metabolism_Homo sapiens_hsa012120.51177462
88cAMP signaling pathway_Homo sapiens_hsa040240.50914410
89Serotonergic synapse_Homo sapiens_hsa047260.50852926
90HIF-1 signaling pathway_Homo sapiens_hsa040660.50197741
91Choline metabolism in cancer_Homo sapiens_hsa052310.47526456
92Viral myocarditis_Homo sapiens_hsa054160.46072104
93Fatty acid elongation_Homo sapiens_hsa000620.45144182
94Platelet activation_Homo sapiens_hsa046110.42902120
95Mineral absorption_Homo sapiens_hsa049780.42139561
96Melanogenesis_Homo sapiens_hsa049160.41734024
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.41313252
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41193085
99Butanoate metabolism_Homo sapiens_hsa006500.39308399
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38512865
101Inositol phosphate metabolism_Homo sapiens_hsa005620.37445317
102Bile secretion_Homo sapiens_hsa049760.35631680
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35537898
104Regulation of autophagy_Homo sapiens_hsa041400.35268886
105Estrogen signaling pathway_Homo sapiens_hsa049150.33808668
106Prion diseases_Homo sapiens_hsa050200.32506448
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30578808
108Collecting duct acid secretion_Homo sapiens_hsa049660.30004231
109Glioma_Homo sapiens_hsa052140.28783425
110Ras signaling pathway_Homo sapiens_hsa040140.28048730
111Protein export_Homo sapiens_hsa030600.26166046
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25775351
113Oocyte meiosis_Homo sapiens_hsa041140.25625492
114Alcoholism_Homo sapiens_hsa050340.25578590
115Amoebiasis_Homo sapiens_hsa051460.25439002
116Renal cell carcinoma_Homo sapiens_hsa052110.25259715
117Vibrio cholerae infection_Homo sapiens_hsa051100.25158201
118ErbB signaling pathway_Homo sapiens_hsa040120.23772531
119Proteoglycans in cancer_Homo sapiens_hsa052050.23675326
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17021566
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16228484
122Endocytosis_Homo sapiens_hsa041440.15700439
123Phototransduction_Homo sapiens_hsa047440.14740292
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13679204
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09139285
126Non-small cell lung cancer_Homo sapiens_hsa052230.07020493
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.03862877
128Rap1 signaling pathway_Homo sapiens_hsa040150.01322203
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.01223523

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