PVR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.16850392
2Golgi transport vesicle coating (GO:0048200)5.16850392
3protein localization to endosome (GO:0036010)4.39685824
4cell adhesion mediated by integrin (GO:0033627)4.35788574
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.22326500
6wound healing, spreading of epidermal cells (GO:0035313)4.11629828
7protein retention in ER lumen (GO:0006621)4.07867425
8NIK/NF-kappaB signaling (GO:0038061)4.01236872
9negative regulation of fibrinolysis (GO:0051918)3.94090476
10regulation of interleukin-12 biosynthetic process (GO:0045075)3.87285896
11regulation of integrin activation (GO:0033623)3.77202414
12desmosome organization (GO:0002934)3.72996284
13response to muramyl dipeptide (GO:0032495)3.70218836
14regulation of plasminogen activation (GO:0010755)3.69923305
15positive regulation of p38MAPK cascade (GO:1900745)3.46778414
16protein hydroxylation (GO:0018126)3.31511814
17mesodermal cell differentiation (GO:0048333)3.27322546
18adherens junction assembly (GO:0034333)3.25621781
19peptidyl-proline hydroxylation (GO:0019511)3.25405271
20cell-substrate adherens junction assembly (GO:0007045)3.23460692
21focal adhesion assembly (GO:0048041)3.23460692
22chondrocyte proliferation (GO:0035988)3.18272826
23regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.17131688
24apoptotic cell clearance (GO:0043277)3.16961684
25regulation of fibrinolysis (GO:0051917)3.16169303
26negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.14687991
27positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.13974977
28positive regulation of endothelial cell apoptotic process (GO:2000353)3.12251330
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.11701795
30endodermal cell differentiation (GO:0035987)3.10967168
31wound healing, spreading of cells (GO:0044319)3.10763844
32fibrinolysis (GO:0042730)3.10117510
33modulation by symbiont of host cellular process (GO:0044068)3.09027819
34positive regulation of osteoblast proliferation (GO:0033690)3.05458749
35stress fiber assembly (GO:0043149)3.04555942
36skin morphogenesis (GO:0043589)3.04055890
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03928924
38dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.01815104
39positive regulation of blood vessel endothelial cell migration (GO:0043536)3.00477962
40cytoskeletal anchoring at plasma membrane (GO:0007016)2.97358998
41protein maturation by protein folding (GO:0022417)2.96963360
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96718579
43regulation of early endosome to late endosome transport (GO:2000641)2.94810343
44low-density lipoprotein particle clearance (GO:0034383)2.93004335
45positive regulation of interferon-alpha production (GO:0032727)2.92220523
46natural killer cell mediated immunity (GO:0002228)2.91996457
47natural killer cell mediated cytotoxicity (GO:0042267)2.91996457
48positive regulation of natural killer cell differentiation (GO:0032825)2.89189369
49protein carboxylation (GO:0018214)2.88160965
50peptidyl-glutamic acid carboxylation (GO:0017187)2.88160965
51hyaluronan catabolic process (GO:0030214)2.86453958
52vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.84728166
53vascular endothelial growth factor signaling pathway (GO:0038084)2.82499443
54negative regulation of chondrocyte differentiation (GO:0032331)2.81954849
55growth hormone receptor signaling pathway (GO:0060396)2.81150449
56membrane protein ectodomain proteolysis (GO:0006509)2.80706916
57regulation of transforming growth factor beta2 production (GO:0032909)2.76797480
58COPII vesicle coating (GO:0048208)2.76777498
59barbed-end actin filament capping (GO:0051016)2.76300203
60regulation of interferon-alpha production (GO:0032647)2.75626707
61establishment of endothelial barrier (GO:0061028)2.75209881
62positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.74013523
63cellular response to interferon-alpha (GO:0035457)2.72378155
64positive regulation by symbiont of host defense response (GO:0052509)2.71889449
65modulation by symbiont of host defense response (GO:0052031)2.71889449
66modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71889449
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71889449
68positive regulation by organism of defense response of other organism involved in symbiotic interact2.71889449
69modulation by symbiont of host immune response (GO:0052553)2.71889449
70regulation of T-helper 1 cell differentiation (GO:0045625)2.71792509
71activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.70997466
72activation of Rac GTPase activity (GO:0032863)2.69948103
73regulation of transforming growth factor beta1 production (GO:0032908)2.68141575
74vesicle coating (GO:0006901)2.64296637
75substrate-dependent cell migration (GO:0006929)2.64180363
76cell-substrate junction assembly (GO:0007044)2.64103740
77regulation of apoptotic process involved in morphogenesis (GO:1902337)2.63322889
78semaphorin-plexin signaling pathway (GO:0071526)2.63156708
79positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.62960869
80actin filament depolymerization (GO:0030042)2.62600669
81atrioventricular valve morphogenesis (GO:0003181)2.62003586
82positive regulation of gamma-delta T cell activation (GO:0046645)2.60182842
83response to laminar fluid shear stress (GO:0034616)2.59832592
84response to peptidoglycan (GO:0032494)2.59396280
85regulation of p38MAPK cascade (GO:1900744)2.57901837
86endothelial cell morphogenesis (GO:0001886)2.57762100
87cellular copper ion homeostasis (GO:0006878)2.57629777
88pinocytosis (GO:0006907)2.57330456
89endocytic recycling (GO:0032456)2.56836109
90hypotonic response (GO:0006971)2.56641052
91endoplasmic reticulum unfolded protein response (GO:0030968)2.56420653
92hepatocyte apoptotic process (GO:0097284)2.56140182
93positive regulation of nuclease activity (GO:0032075)2.55901069
94positive regulation of extracellular matrix organization (GO:1903055)2.55853248
95branching involved in salivary gland morphogenesis (GO:0060445)2.55404086
96heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.55385003
97positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.55380459
98positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.54372202
994-hydroxyproline metabolic process (GO:0019471)2.53651954
100basement membrane organization (GO:0071711)2.53239015
101retina vasculature morphogenesis in camera-type eye (GO:0061299)2.52941145
102gap junction assembly (GO:0016264)2.52760721
103neutrophil activation involved in immune response (GO:0002283)2.52109167
104positive regulation of heat generation (GO:0031652)2.52021604
105negative regulation of anoikis (GO:2000811)2.51900913
106positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.51185628
107platelet degranulation (GO:0002576)2.51086337
108regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.50193775
109negative regulation of fatty acid transport (GO:2000192)2.49138065
110collagen fibril organization (GO:0030199)2.47680169
111regulation of glomerular filtration (GO:0003093)2.47668950
112type B pancreatic cell proliferation (GO:0044342)2.47486717
113positive regulation of interleukin-12 production (GO:0032735)2.46287443
114negative regulation of lipid storage (GO:0010888)2.46144332
115endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.46075930
116epithelial cell-cell adhesion (GO:0090136)2.45440495
117positive regulation of chemokine biosynthetic process (GO:0045080)2.45006109
118mRNA transcription (GO:0009299)2.44807855
119negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.44471792
120ER-nucleus signaling pathway (GO:0006984)2.43488649
121regulation of membrane protein ectodomain proteolysis (GO:0051043)2.43372221
122cell migration involved in sprouting angiogenesis (GO:0002042)2.43011429
123extracellular matrix disassembly (GO:0022617)2.42768971
124regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.42191794
125collagen metabolic process (GO:0032963)2.41189390
126regulation of interferon-beta biosynthetic process (GO:0045357)2.41137828
127heterotypic cell-cell adhesion (GO:0034113)2.40936343
128regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.39910192
129cellular response to vitamin D (GO:0071305)2.38655192
130positive regulation of protein oligomerization (GO:0032461)2.38603399
131positive regulation of epithelial cell migration (GO:0010634)2.38275596
132tyrosine phosphorylation of STAT protein (GO:0007260)2.38206005
133regulation of glucose import in response to insulin stimulus (GO:2001273)2.37983596
134blood vessel endothelial cell migration (GO:0043534)2.37933001
135regulation of tight junction assembly (GO:2000810)2.37382008
136myeloid cell homeostasis (GO:0002262)2.37228567
137cellular response to unfolded protein (GO:0034620)2.36650721
138positive regulation of endothelial cell migration (GO:0010595)2.36594900
139membrane raft organization (GO:0031579)2.35996318
140cellular response to growth hormone stimulus (GO:0071378)2.35609121
141regulation of mononuclear cell migration (GO:0071675)2.35592569
142regulation of interleukin-12 production (GO:0032655)2.34793209
143lipopolysaccharide-mediated signaling pathway (GO:0031663)2.34593521
144negative regulation of interleukin-12 production (GO:0032695)2.34522568
145mammary gland epithelial cell proliferation (GO:0033598)2.34397629
146endocardial cushion development (GO:0003197)2.33739022
147fibroblast migration (GO:0010761)2.33730140
148actin filament bundle organization (GO:0061572)2.33516341
149actin filament bundle assembly (GO:0051017)2.33516341
150interferon-gamma secretion (GO:0072643)2.33180251
151positive regulation of astrocyte differentiation (GO:0048711)2.33135406
152regulation of T cell tolerance induction (GO:0002664)2.32636005
153cytokine secretion (GO:0050663)2.32512110
154positive regulation of receptor recycling (GO:0001921)2.32474077
155plasma membrane repair (GO:0001778)2.32285866
156regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.32266226
157positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.31872448
158positive regulation of interferon-beta production (GO:0032728)2.30453848
159cellular response to virus (GO:0098586)2.30123003
160macrophage activation involved in immune response (GO:0002281)2.28819710
161cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.28772069
162myeloid dendritic cell differentiation (GO:0043011)2.27549799
163hemidesmosome assembly (GO:0031581)2.26430210
164antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.25652659
165antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.25652659
166response to fluid shear stress (GO:0034405)2.25565441
167ruffle organization (GO:0031529)2.25078265
168regulation of fever generation (GO:0031620)2.24849366
169apoptotic process involved in morphogenesis (GO:0060561)2.24713993
170regulation of gamma-delta T cell activation (GO:0046643)2.24639795
171response to interferon-alpha (GO:0035455)2.24375371
172substrate adhesion-dependent cell spreading (GO:0034446)2.24158184
173regulation of necroptotic process (GO:0060544)2.21429268
174positive regulation of interleukin-2 production (GO:0032743)2.21356517
175antigen processing and presentation of endogenous antigen (GO:0019883)2.20198792
176regulation of type I interferon-mediated signaling pathway (GO:0060338)2.19629651
177granulocyte activation (GO:0036230)2.18222153

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.27072729
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.31293374
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.18888558
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.04494925
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.30226240
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.16563705
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.08411772
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.93350405
9ZNF263_19887448_ChIP-Seq_K562_Human2.88890919
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.85676552
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.81203916
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.74402692
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.69055599
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.64700892
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.47490749
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.41232628
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.32437638
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.30177110
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22174051
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18137034
21CLOCK_20551151_ChIP-Seq_293T_Human2.17542575
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13539371
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11542300
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10794235
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10109747
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.04550232
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.04550232
28IRF8_27001747_Chip-Seq_BMDM_Mouse2.03127493
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.02292284
30* ELK3_25401928_ChIP-Seq_HUVEC_Human1.93639931
31* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.93609095
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.80118723
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.76379986
34* LXR_22292898_ChIP-Seq_THP-1_Human1.74549824
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.69483844
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.69024047
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.66310930
38TP53_22127205_ChIP-Seq_IMR90_Human1.65733884
39* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.65309546
40CJUN_26792858_Chip-Seq_BT549_Human1.64426893
41AR_21909140_ChIP-Seq_LNCAP_Human1.64400586
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.64247508
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.62011738
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61887394
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59114399
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56593360
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55283391
48* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54530246
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54487321
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53204834
51ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.52967967
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.52604128
53BRD4_25478319_ChIP-Seq_HGPS_Human1.49313868
54MAF_26560356_Chip-Seq_TH1_Human1.48573903
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48166378
56TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48049297
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.46747368
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45165060
59JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44868927
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44623935
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44593097
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44570455
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43020212
64RUNX_20019798_ChIP-Seq_JUKART_Human1.41572618
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38968764
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38761822
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36181057
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.35824181
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35145301
70PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34189548
71ATF3_27146783_Chip-Seq_COLON_Human1.32186621
72JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31728714
73MYB_26560356_Chip-Seq_TH2_Human1.31509503
74* TCF7_22412390_ChIP-Seq_EML_Mouse1.31351255
75VDR_24787735_ChIP-Seq_THP-1_Human1.31292373
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30357175
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30322944
78VDR_21846776_ChIP-Seq_THP-1_Human1.29861970
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28903238
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27198346
81VDR_24763502_ChIP-Seq_THP-1_Human1.25945846
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25913329
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25278747
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24570072
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.24261600
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23597309
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23183849
88KDM2B_26808549_Chip-Seq_K562_Human1.22737832
89KDM2B_26808549_Chip-Seq_DND41_Human1.22645789
90WT1_19549856_ChIP-ChIP_CCG9911_Human1.21946379
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20338190
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19343731
93MYB_26560356_Chip-Seq_TH1_Human1.18861225
94FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18403407
95P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18218304
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18199997
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17321969
98RACK7_27058665_Chip-Seq_MCF-7_Human1.15783388
99MYC_22102868_ChIP-Seq_BL_Human1.14659429
100SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13299217
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11842933
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11117638
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09058743
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08864793
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08784473
106P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08679283
107* SOX2_20726797_ChIP-Seq_SW620_Human1.07792188
108LXR_22158963_ChIP-Seq_LIVER_Mouse1.06982343
109TBX20_22080862_ChIP-Seq_HEART_Mouse1.06959961
110TBX20_22328084_ChIP-Seq_HEART_Mouse1.06959961
111SPI1_23127762_ChIP-Seq_K562_Human1.06241581
112ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06215103
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06196071
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05954355
115UTX_26944678_Chip-Seq_JUKART_Human1.05540005
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05336760
117PU_27001747_Chip-Seq_BMDM_Mouse1.04433067
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04111796
119SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03387500
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02838955
121ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02786504
122SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01918415
123SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01460313
124MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01095351
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00912889
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00056532
127RUNX1_22412390_ChIP-Seq_EML_Mouse0.99679354
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99416609
129FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98394640
130TET1_21451524_ChIP-Seq_MESCs_Mouse0.98309487
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97535788
132ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97224795
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96149660
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96149660
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95118774
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94963853
137* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94835274
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.94251579
139THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94233947
140GATA6_25053715_ChIP-Seq_YYC3_Human0.92174600
141TP53_23651856_ChIP-Seq_MEFs_Mouse0.91951320
142* TET1_21490601_ChIP-Seq_MESCs_Mouse0.91728461
143SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91486919
144* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91397574
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.90464470
146ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90158766
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88547227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.45545592
2MP0010352_gastrointestinal_tract_polyps2.94486219
3MP0003705_abnormal_hypodermis_morpholog2.88229217
4MP0003566_abnormal_cell_adhesion2.87920732
5MP0009840_abnormal_foam_cell2.64810915
6MP0004510_myositis2.52497119
7MP0003091_abnormal_cell_migration2.28116551
8MP0003436_decreased_susceptibility_to2.27619094
9MP0005451_abnormal_body_composition2.22656508
10MP0003303_peritoneal_inflammation2.12892768
11MP0000750_abnormal_muscle_regeneration2.01685764
12MP0003191_abnormal_cellular_cholesterol2.01597587
13MP0003279_aneurysm2.01093895
14MP0004233_abnormal_muscle_weight2.00465165
15MP0009278_abnormal_bone_marrow2.00443334
16MP0000733_abnormal_muscle_development1.99330525
17MP0005023_abnormal_wound_healing1.99109209
18MP0005275_abnormal_skin_tensile1.94648723
19MP0005623_abnormal_meninges_morphology1.93957954
20MP0005076_abnormal_cell_differentiation1.90210859
21MP0002139_abnormal_hepatobiliary_system1.78459096
22MP0001958_emphysema1.77968932
23MP0003300_gastrointestinal_ulcer1.77861407
24MP0009785_altered_susceptibility_to1.77745321
25MP0000013_abnormal_adipose_tissue1.77368374
26MP0002138_abnormal_hepatobiliary_system1.75489514
27MP0000685_abnormal_immune_system1.72171894
28MP0004947_skin_inflammation1.69323913
29MP0001849_ear_inflammation1.66890936
30MP0001835_abnormal_antigen_presentation1.66868565
31MP0003448_altered_tumor_morphology1.66821327
32MP0002877_abnormal_melanocyte_morpholog1.64786765
33MP0002166_altered_tumor_susceptibility1.63360105
34MP0004858_abnormal_nervous_system1.63271194
35MP0003828_pulmonary_edema1.60760706
36MP0002148_abnormal_hypersensitivity_rea1.58301933
37MP0004272_abnormal_basement_membrane1.56115216
38MP0003950_abnormal_plasma_membrane1.55869270
39MP0003724_increased_susceptibility_to1.55336598
40MP0000858_altered_metastatic_potential1.54987907
41MP0002254_reproductive_system_inflammat1.54783388
42MP0002006_tumorigenesis1.54577666
43MP0000767_abnormal_smooth_muscle1.54467670
44MP0005000_abnormal_immune_tolerance1.51865507
45MP0002419_abnormal_innate_immunity1.48011642
46MP0000751_myopathy1.47840884
47MP0003453_abnormal_keratinocyte_physiol1.47101712
48MP0000537_abnormal_urethra_morphology1.46479099
49MP0005360_urolithiasis1.44320460
50MP0001853_heart_inflammation1.43968931
51MP0001533_abnormal_skeleton_physiology1.43819705
52MP0003045_fibrosis1.43731869
53MP0005387_immune_system_phenotype1.40771851
54MP0001790_abnormal_immune_system1.40771851
55MP0001879_abnormal_lymphatic_vessel1.39520745
56MP0009053_abnormal_anal_canal1.37704594
57MP0000003_abnormal_adipose_tissue1.34929595
58MP0010030_abnormal_orbit_morphology1.32132451
59MP0010368_abnormal_lymphatic_system1.31839792
60* MP0002452_abnormal_antigen_presenting1.31316876
61MP0000343_altered_response_to1.31213275
62MP0000762_abnormal_tongue_morphology1.29196566
63MP0006082_CNS_inflammation1.29008959
64MP0002405_respiratory_system_inflammati1.26478791
65MP0009780_abnormal_chondrocyte_physiolo1.25640875
66MP0002896_abnormal_bone_mineralization1.25075873
67MP0002998_abnormal_bone_remodeling1.23355024
68MP0010155_abnormal_intestine_physiology1.22697294
69MP0005397_hematopoietic_system_phenotyp1.22553357
70MP0001545_abnormal_hematopoietic_system1.22553357
71MP0000569_abnormal_digit_pigmentation1.22389181
72MP0002933_joint_inflammation1.22037116
73MP0001348_abnormal_lacrimal_gland1.21342864
74* MP0005025_abnormal_response_to1.19486319
75MP0005409_darkened_coat_color1.17321665
76* MP0002723_abnormal_immune_serum1.17306779
77* MP0001800_abnormal_humoral_immune1.14769237
78MP0005165_increased_susceptibility_to1.14539384
79MP0005197_abnormal_uvea_morphology1.14183929
80MP0002796_impaired_skin_barrier1.13846579
81MP0004808_abnormal_hematopoietic_stem1.12723104
82MP0002060_abnormal_skin_morphology1.08877721
83MP0000467_abnormal_esophagus_morphology1.08821761
84MP0010234_abnormal_vibrissa_follicle1.08368683
85MP0005501_abnormal_skin_physiology1.08289181
86MP0005390_skeleton_phenotype1.06868580
87* MP0001819_abnormal_immune_cell1.06220113
88MP0005257_abnormal_intraocular_pressure1.06218042
89MP0002332_abnormal_exercise_endurance1.04255783
90* MP0002420_abnormal_adaptive_immunity1.04051642
91MP0006054_spinal_hemorrhage1.03376286
92MP0004084_abnormal_cardiac_muscle1.02645626
93MP0003868_abnormal_feces_composition0.99615141
94MP0002295_abnormal_pulmonary_circulatio0.99076057
95MP0001243_abnormal_dermal_layer0.99025702
96MP0000249_abnormal_blood_vessel0.97291128
97MP0001915_intracranial_hemorrhage0.97052176
98MP0004087_abnormal_muscle_fiber0.96807237
99MP0009333_abnormal_splenocyte_physiolog0.96802714
100MP0005503_abnormal_tendon_morphology0.96648111
101MP0010630_abnormal_cardiac_muscle0.96361588
102MP0001216_abnormal_epidermal_layer0.96235292
103MP0005164_abnormal_response_to0.95914588
104MP0010307_abnormal_tumor_latency0.94711874
105MP0005058_abnormal_lysosome_morphology0.94519063
106MP0005330_cardiomyopathy0.94460225
107MP0001661_extended_life_span0.94138861
108MP0001845_abnormal_inflammatory_respons0.93518981
109MP0009764_decreased_sensitivity_to0.93134036
110MP0005595_abnormal_vascular_smooth0.92892827
111MP0000759_abnormal_skeletal_muscle0.91401916
112MP0002168_other_aberrant_phenotype0.91132093
113MP0002089_abnormal_postnatal_growth/wei0.88617559
114MP0003385_abnormal_body_wall0.87039853
115MP0003941_abnormal_skin_development0.86105327
116MP0006138_congestive_heart_failure0.84768292
117MP0001542_abnormal_bone_strength0.84699108
118MP0005508_abnormal_skeleton_morphology0.84509805
119MP0005167_abnormal_blood-brain_barrier0.84246028
120MP0009384_cardiac_valve_regurgitation0.84189257
121MP0000534_abnormal_ureter_morphology0.84170781
122MP0001614_abnormal_blood_vessel0.83988375
123MP0002925_abnormal_cardiovascular_devel0.83514153
124MP0000627_abnormal_mammary_gland0.81955364
125MP0000678_abnormal_parathyroid_gland0.81748416
126MP0000749_muscle_degeneration0.81604421
127MP0003075_altered_response_to0.81240680
128MP0002128_abnormal_blood_circulation0.80523873
129MP0005464_abnormal_platelet_physiology0.78919709
130MP0008775_abnormal_heart_ventricle0.78794962
131MP0003763_abnormal_thymus_physiology0.78604683
132MP0005375_adipose_tissue_phenotype0.78032735
133MP0000747_muscle_weakness0.77713452
134MP0002398_abnormal_bone_marrow0.77493756
135MP0000716_abnormal_immune_system0.77229945
136MP0004185_abnormal_adipocyte_glucose0.76994771
137MP0005671_abnormal_response_to0.76365896
138MP0003329_amyloid_beta_deposits0.76099822
139MP0008260_abnormal_autophagy0.76061066
140MP0005621_abnormal_cell_physiology0.75876954
141MP0004782_abnormal_surfactant_physiolog0.75355725
142MP0002086_abnormal_extraembryonic_tissu0.72761169
143MP0002269_muscular_atrophy0.71008535
144MP0005193_abnormal_anterior_eye0.68884406
145MP0000462_abnormal_digestive_system0.68627666
146MP0010771_integument_phenotype0.66901636
147MP0000579_abnormal_nail_morphology0.66205842
148MP0001299_abnormal_eye_distance/0.65530471
149MP0001730_embryonic_growth_arrest0.62909237
150MP0002697_abnormal_eye_size0.61205378
151MP0005365_abnormal_bile_salt0.61174564

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.02827254
2Protrusio acetabuli (HP:0003179)3.93956819
3Increased connective tissue (HP:0009025)3.59441440
4Arterial tortuosity (HP:0005116)3.45035653
5Peritonitis (HP:0002586)3.39333369
6Osteolytic defects of the phalanges of the hand (HP:0009771)3.30474346
7Osteolytic defects of the hand bones (HP:0009699)3.30474346
8Cerebral aneurysm (HP:0004944)3.27982194
9Distal lower limb amyotrophy (HP:0008944)3.20001016
10Aortic dissection (HP:0002647)3.00768755
11Myocardial infarction (HP:0001658)2.95670748
12Vertebral compression fractures (HP:0002953)2.92851920
13Aortic aneurysm (HP:0004942)2.91261634
14Deep venous thrombosis (HP:0002625)2.89945549
15Right ventricular cardiomyopathy (HP:0011663)2.89879396
16Elevated erythrocyte sedimentation rate (HP:0003565)2.81440454
17Difficulty climbing stairs (HP:0003551)2.80030431
18Mitral stenosis (HP:0001718)2.79431139
19Achilles tendon contracture (HP:0001771)2.78597497
20Cervical subluxation (HP:0003308)2.77000293
21Eczematoid dermatitis (HP:0000976)2.74530843
22Broad face (HP:0000283)2.73347457
23Abnormality of the Achilles tendon (HP:0005109)2.72508931
24Increased density of long bones (HP:0006392)2.70185505
25Atrophic scars (HP:0001075)2.70095861
26Distal lower limb muscle weakness (HP:0009053)2.66058234
27Orchitis (HP:0100796)2.62795998
28Muscle fiber splitting (HP:0003555)2.59515186
29Shallow orbits (HP:0000586)2.59229822
30Dilatation of the ascending aorta (HP:0005111)2.59069226
31Interstitial pulmonary disease (HP:0006530)2.57161219
32Cardiovascular calcification (HP:0011915)2.56024307
33Hyporeflexia of lower limbs (HP:0002600)2.54974901
34Abnormality of dentin (HP:0010299)2.53226348
35Myositis (HP:0100614)2.48885917
36Hematochezia (HP:0002573)2.45137763
37Short nail (HP:0001799)2.39280907
38Hyperacusis (HP:0010780)2.38663499
39Bladder diverticulum (HP:0000015)2.37762181
40Spinal rigidity (HP:0003306)2.32781400
41Distal upper limb amyotrophy (HP:0007149)2.30723023
42Upper limb amyotrophy (HP:0009129)2.30723023
43Esophageal varix (HP:0002040)2.30124828
44Recurrent abscess formation (HP:0002722)2.28893308
45Persistence of primary teeth (HP:0006335)2.27768464
46Wormian bones (HP:0002645)2.27444121
47Vascular calcification (HP:0004934)2.26417082
48Trismus (HP:0000211)2.22827228
49Abnormality of the distal phalanges of the toes (HP:0010182)2.20644573
50Abnormality of the acetabulum (HP:0003170)2.19793364
51Ankle contracture (HP:0006466)2.19491350
52Aneurysm (HP:0002617)2.19375399
53Autoimmune thrombocytopenia (HP:0001973)2.15870689
54Radial bowing (HP:0002986)2.14325024
55Abnormality of carpal bone ossification (HP:0006257)2.14163241
56Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.14128701
57Tetraparesis (HP:0002273)2.14039557
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.13889037
59Mitral valve prolapse (HP:0001634)2.13757336
60Natal tooth (HP:0000695)2.13197448
61Mitral regurgitation (HP:0001653)2.12944879
62Soft skin (HP:0000977)2.11887004
63Lower limb amyotrophy (HP:0007210)2.11415039
64Blue sclerae (HP:0000592)2.08934486
65Genu recurvatum (HP:0002816)2.08538623
66Recurrent fungal infections (HP:0002841)2.07371279
67Scapular winging (HP:0003691)2.06856558
68Retrobulbar optic neuritis (HP:0100654)2.06130988
69Optic neuritis (HP:0100653)2.06130988
70Abnormal ossification of hand bones (HP:0005921)2.05408832
71Recurrent bacterial skin infections (HP:0005406)2.04854770
72Fused cervical vertebrae (HP:0002949)2.03181530
73Thin bony cortex (HP:0002753)2.01880414
74Subacute progressive viral hepatitis (HP:0006572)2.01765928
75Stomatitis (HP:0010280)2.00019587
76Type 1 muscle fiber predominance (HP:0003803)1.97412249
77Frequent falls (HP:0002359)1.97278549
78Difficulty running (HP:0009046)1.97086136
79Disproportionate tall stature (HP:0001519)1.95494449
80Ulnar bowing (HP:0003031)1.95268977
81Generalized amyotrophy (HP:0003700)1.93560576
82Muscle fiber inclusion bodies (HP:0100299)1.92590078
83Increased mean platelet volume (HP:0011877)1.92048233
84Pulmonary artery stenosis (HP:0004415)1.91916547
85Arterial thrombosis (HP:0004420)1.91645884
86Bowed forearm bones (HP:0003956)1.91393672
87Bowing of the arm (HP:0006488)1.91393672
88Bilateral sensorineural hearing impairment (HP:0008619)1.90935691
89Fragile skin (HP:0001030)1.90926187
90Mucopolysacchariduria (HP:0008155)1.90626070
91Urinary glycosaminoglycan excretion (HP:0003541)1.90626070
92Coxa vara (HP:0002812)1.90399145
93Mildly elevated creatine phosphokinase (HP:0008180)1.90243474
94Recurrent viral infections (HP:0004429)1.89491752
95Hand muscle atrophy (HP:0009130)1.89171393
96Nuclear cataract (HP:0100018)1.89075175
97Back pain (HP:0003418)1.89005623
98Abnormality of the peritoneum (HP:0002585)1.88831896
99Axonal loss (HP:0003447)1.88568983
100Follicular hyperkeratosis (HP:0007502)1.88035913
101Thick nail (HP:0001805)1.87712260
102Reduced subcutaneous adipose tissue (HP:0003758)1.87323113
103Abnormality of proline metabolism (HP:0010907)1.87297165
104Hydroxyprolinuria (HP:0003080)1.87297165
105Syringomyelia (HP:0003396)1.86459572
106Spinal cord lesions (HP:0100561)1.86459572
107Eosinophilia (HP:0001880)1.86367303
108Abnormality of glycolipid metabolism (HP:0010969)1.86128083
109Abnormality of liposaccharide metabolism (HP:0010968)1.86128083
110Abnormality of glycosphingolipid metabolism (HP:0004343)1.86128083
111Absent frontal sinuses (HP:0002688)1.85744612
112Malignant hyperthermia (HP:0002047)1.84229901
113Abnormality of the nasal septum (HP:0000419)1.83845557
114Abnormality of oral frenula (HP:0000190)1.82398563
115Round ear (HP:0100830)1.81910979
116Cerebral inclusion bodies (HP:0100314)1.81389025
117Pterygium (HP:0001059)1.81100910
118Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81044687
119Abnormality of polysaccharide metabolism (HP:0011012)1.81044687
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81044687
121Leukocytosis (HP:0001974)1.80129188
122Dysostosis multiplex (HP:0000943)1.79874301
123Biconcave vertebral bodies (HP:0004586)1.79373097
124Focal segmental glomerulosclerosis (HP:0000097)1.78761169
125Wrist flexion contracture (HP:0001239)1.78744515
126Advanced eruption of teeth (HP:0006288)1.78529745
127Neonatal death (HP:0003811)1.78379514
128Pulmonary infiltrates (HP:0002113)1.77828300
129Joint laxity (HP:0001388)1.77021037
130Abnormal platelet volume (HP:0011876)1.76832070
131Abnormal delivery (HP:0001787)1.76396284
132Joint contractures involving the joints of the feet (HP:0100492)1.75821580
133Flexion contracture of toe (HP:0005830)1.75821580
134Camptodactyly of toe (HP:0001836)1.75255267
135Abnormality of the umbilical cord (HP:0010881)1.74649388
136Increased variability in muscle fiber diameter (HP:0003557)1.74500827
137Abnormality of the calcaneus (HP:0008364)1.74370373
138Spondylolisthesis (HP:0003302)1.74312709
139Elbow flexion contracture (HP:0002987)1.73538295
140Selective tooth agenesis (HP:0001592)1.73082096
141Flat acetabular roof (HP:0003180)1.72177870
142Hyperextensible skin (HP:0000974)1.72043434
143Ankyloglossia (HP:0010296)1.71541124
144EMG: myopathic abnormalities (HP:0003458)1.71323884
145Abnormality of the intrinsic pathway (HP:0010989)1.71103889
146Conjugated hyperbilirubinemia (HP:0002908)1.71048572
147Vascular tortuosity (HP:0004948)1.70674065
148Abnormality of the pericardium (HP:0001697)1.70489080
149Neonatal short-limb short stature (HP:0008921)1.70303731
150Asymmetric septal hypertrophy (HP:0001670)1.70000158
151Abnormality of macrophages (HP:0004311)1.69467243
152Menorrhagia (HP:0000132)1.68693628
153Pustule (HP:0200039)1.68427945
154Ulnar deviation of the wrist (HP:0003049)1.67713075
155Spinal cord compression (HP:0002176)1.67528707
156Mediastinal lymphadenopathy (HP:0100721)1.67226345
157Joint stiffness (HP:0001387)1.66876757
158Abnormal vertebral ossification (HP:0100569)1.64769157

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.35759698
2TTN3.15047831
3EPHA23.04254998
4TBK12.51924740
5ERN12.51118822
6LMTK22.41088204
7PIM22.30288906
8FGFR42.27832229
9LATS22.25445080
10TRIB32.24653565
11ICK2.05374729
12CDK122.05064223
13EPHB12.02917123
14RPS6KA42.00240373
15TYK21.99644447
16JAK31.92518935
17BMX1.91882227
18MYLK1.83800188
19NTRK11.83392734
20IRAK31.82198837
21IKBKB1.81565279
22CHUK1.80926721
23PKN21.68415790
24MAP3K31.63302624
25LATS11.60055047
26IKBKE1.59247420
27DDR21.57889888
28SMG11.52688226
29PTK61.52301515
30RIPK11.48797555
31STK101.48584736
32JAK11.47039998
33MAP3K131.45014541
34DMPK1.43168409
35TRPM71.42748943
36EPHA31.42205417
37NEK91.36130098
38CDK61.32009082
39ARAF1.29945426
40TIE11.27867586
41FGFR31.26996976
42PIM11.25429468
43MOS1.24987162
44SCYL21.24532859
45TXK1.22472710
46PDGFRA1.19498078
47CSK1.19388030
48LRRK21.18497877
49PAK41.16047796
50TGFBR21.14124962
51MST1R1.13431823
52MAP4K11.11738193
53PTK21.10183899
54MAP2K31.03697944
55PRPF4B1.03237278
56STK30.99750186
57EEF2K0.97731644
58TESK10.97289001
59STK380.95551592
60PAK20.94380150
61ABL20.93818052
62ZAP700.93181131
63PDGFRB0.92657735
64CDK80.91959013
65RPS6KB20.91744751
66KIT0.87290419
67KDR0.86912432
68MTOR0.86663634
69NME20.86111577
70HCK0.83049924
71MARK30.80825726
72MAP3K100.80805795
73FER0.78114223
74CDC42BPA0.77404388
75MET0.76699550
76MAP3K90.74546978
77FLT30.74198437
78MAP3K120.72133259
79EPHB20.70797209
80STK240.69777888
81PBK0.66077616
82ERBB40.65242179
83PRKD20.63355029
84ILK0.63312602
85ITK0.63168192
86ABL10.60595114
87TESK20.59207407
88PIK3CG0.58897052
89GSK3A0.58744296
90MAP3K80.58250880
91SIK10.57451500
92RPS6KA20.56867729
93MAP3K60.56218253
94EGFR0.55896463
95PDPK10.55207685
96MAPKAPK30.55011739
97MAPKAPK20.53402856
98ROCK20.53183964
99NEK10.53092234
100RPS6KA50.52043816
101PIK3CA0.50713301
102TGFBR10.49725327
103NUAK10.49583173
104MAP3K110.48676186
105* INSR0.48574804
106MELK0.48489995
107CAMK1D0.48303733
108BRAF0.48128878
109NLK0.47950956
110MAP3K50.47849452
111MAPK110.46982209
112* LCK0.46941485
113KSR20.46694615
114ERBB30.46166662
115CAMK2G0.45709553
116PRKG20.45631213
117DAPK30.44917029
118BLK0.44655173
119PTK2B0.44109445
120IRAK20.44080453
121MAP3K10.44033731
122FGFR10.43294748
123CDK40.42992382
124DYRK1B0.42784652
125LIMK10.42261322
126STK40.41963230
127GRK70.41819350
128IRAK40.41724913
129TAOK20.41256267
130CDK90.40829433
131STK38L0.40590593
132CSF1R0.40316608
133JAK20.38371579
134AKT20.38151570
135EIF2AK10.37711357
136ROCK10.37237222
137AURKA0.35627612
138PAK10.34603523
139PRKD30.33395333
140PAK60.31963456
141TAOK10.30693074
142CDK70.30423941
143KSR10.28841431
144CAMK2D0.27559240
145MAP2K10.26688630
146PHKG20.25307579
147PHKG10.25307579
148CAMK2B0.25132368

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.42575894
2Leishmaniasis_Homo sapiens_hsa051402.26271080
3Malaria_Homo sapiens_hsa051442.17864324
4TNF signaling pathway_Homo sapiens_hsa046682.13401739
5Viral myocarditis_Homo sapiens_hsa054162.00863670
6Graft-versus-host disease_Homo sapiens_hsa053322.00246574
7Small cell lung cancer_Homo sapiens_hsa052221.96422603
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94972297
9Legionellosis_Homo sapiens_hsa051341.93565949
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.90838070
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90177767
12Osteoclast differentiation_Homo sapiens_hsa043801.89900623
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88480093
14ECM-receptor interaction_Homo sapiens_hsa045121.88056460
15Toxoplasmosis_Homo sapiens_hsa051451.82533072
16Galactose metabolism_Homo sapiens_hsa000521.82427558
17Measles_Homo sapiens_hsa051621.78304461
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.74300996
19Prion diseases_Homo sapiens_hsa050201.73742315
20Allograft rejection_Homo sapiens_hsa053301.67813887
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67680728
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.65924461
23Apoptosis_Homo sapiens_hsa042101.65633853
24Focal adhesion_Homo sapiens_hsa045101.63740756
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.62225446
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60058434
27Proteoglycans in cancer_Homo sapiens_hsa052051.59384829
28Shigellosis_Homo sapiens_hsa051311.59073874
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54439186
30Adherens junction_Homo sapiens_hsa045201.52011561
31MicroRNAs in cancer_Homo sapiens_hsa052061.51329952
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51136844
33Antigen processing and presentation_Homo sapiens_hsa046121.50831467
34Chronic myeloid leukemia_Homo sapiens_hsa052201.49138198
35Pentose phosphate pathway_Homo sapiens_hsa000301.47650895
36Amoebiasis_Homo sapiens_hsa051461.46466206
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.45925166
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44625372
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.43943651
40Vibrio cholerae infection_Homo sapiens_hsa051101.43662394
41Pertussis_Homo sapiens_hsa051331.41494211
42Hematopoietic cell lineage_Homo sapiens_hsa046401.39019622
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.38572948
44Sulfur metabolism_Homo sapiens_hsa009201.38036491
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37927494
46Fructose and mannose metabolism_Homo sapiens_hsa000511.37417029
47Salmonella infection_Homo sapiens_hsa051321.37361952
48p53 signaling pathway_Homo sapiens_hsa041151.36815971
49Influenza A_Homo sapiens_hsa051641.35126556
50Tuberculosis_Homo sapiens_hsa051521.32582357
51Biosynthesis of amino acids_Homo sapiens_hsa012301.32243946
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31780002
53N-Glycan biosynthesis_Homo sapiens_hsa005101.30359178
54Hepatitis B_Homo sapiens_hsa051611.28588605
55Dilated cardiomyopathy_Homo sapiens_hsa054141.26540339
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.24981319
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24428881
58Acute myeloid leukemia_Homo sapiens_hsa052211.23645776
59Vitamin B6 metabolism_Homo sapiens_hsa007501.22391897
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21621647
61Arginine biosynthesis_Homo sapiens_hsa002201.19243453
62Herpes simplex infection_Homo sapiens_hsa051681.15643650
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14898596
64Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12716976
65Bladder cancer_Homo sapiens_hsa052191.12681479
66Rheumatoid arthritis_Homo sapiens_hsa053231.11681293
67HIF-1 signaling pathway_Homo sapiens_hsa040661.10670149
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09963618
69Sphingolipid metabolism_Homo sapiens_hsa006001.04687190
70T cell receptor signaling pathway_Homo sapiens_hsa046601.04623489
71Staphylococcus aureus infection_Homo sapiens_hsa051501.01874593
72B cell receptor signaling pathway_Homo sapiens_hsa046620.99085255
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98920346
74HTLV-I infection_Homo sapiens_hsa051660.98352613
75Pancreatic cancer_Homo sapiens_hsa052120.98021537
76Hepatitis C_Homo sapiens_hsa051600.94927676
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94494644
78TGF-beta signaling pathway_Homo sapiens_hsa043500.93880841
79Autoimmune thyroid disease_Homo sapiens_hsa053200.93457941
80Viral carcinogenesis_Homo sapiens_hsa052030.93294253
81Primary immunodeficiency_Homo sapiens_hsa053400.91309360
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.90141562
83Thyroid cancer_Homo sapiens_hsa052160.88803615
84Sulfur relay system_Homo sapiens_hsa041220.88266945
85Phenylalanine metabolism_Homo sapiens_hsa003600.87428738
86Prostate cancer_Homo sapiens_hsa052150.85731174
87Chemokine signaling pathway_Homo sapiens_hsa040620.85712704
88Carbon metabolism_Homo sapiens_hsa012000.85674684
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85420038
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83968652
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83967482
92Phagosome_Homo sapiens_hsa041450.83207752
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77415409
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.74266048
95Protein digestion and absorption_Homo sapiens_hsa049740.73530476
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72869553
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72676753
98African trypanosomiasis_Homo sapiens_hsa051430.71771454
99Epstein-Barr virus infection_Homo sapiens_hsa051690.70772276
100Folate biosynthesis_Homo sapiens_hsa007900.70169317
101Platelet activation_Homo sapiens_hsa046110.69842199
102Insulin resistance_Homo sapiens_hsa049310.68822087
103Prolactin signaling pathway_Homo sapiens_hsa049170.68278626
104Pathways in cancer_Homo sapiens_hsa052000.68046059
105FoxO signaling pathway_Homo sapiens_hsa040680.67320463
106Bile secretion_Homo sapiens_hsa049760.66847406
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66423962
108Lysosome_Homo sapiens_hsa041420.65933195
109Starch and sucrose metabolism_Homo sapiens_hsa005000.64837723
110Type I diabetes mellitus_Homo sapiens_hsa049400.64713081
111Melanoma_Homo sapiens_hsa052180.64576883
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64525784
113Dorso-ventral axis formation_Homo sapiens_hsa043200.64323249
114Endocytosis_Homo sapiens_hsa041440.63882050
115Hippo signaling pathway_Homo sapiens_hsa043900.63483549
116Notch signaling pathway_Homo sapiens_hsa043300.61804726
117Insulin signaling pathway_Homo sapiens_hsa049100.61732505
118Glioma_Homo sapiens_hsa052140.61512242
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.61392051
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60285927
121Arginine and proline metabolism_Homo sapiens_hsa003300.58628059
122Rap1 signaling pathway_Homo sapiens_hsa040150.55966377
123Renal cell carcinoma_Homo sapiens_hsa052110.55680997
124Asthma_Homo sapiens_hsa053100.55191792
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55124083
126VEGF signaling pathway_Homo sapiens_hsa043700.53653639
127MAPK signaling pathway_Homo sapiens_hsa040100.51290376
128Tight junction_Homo sapiens_hsa045300.50288087
129ErbB signaling pathway_Homo sapiens_hsa040120.49619466
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.49524457
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49336127
132mTOR signaling pathway_Homo sapiens_hsa041500.49320177
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.49303996
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49296337
135AMPK signaling pathway_Homo sapiens_hsa041520.49084828
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47142115
137Other glycan degradation_Homo sapiens_hsa005110.45093449
138Lysine degradation_Homo sapiens_hsa003100.44972051
139Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44093639
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.44002709
141Axon guidance_Homo sapiens_hsa043600.43781004
142PPAR signaling pathway_Homo sapiens_hsa033200.43393040
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43133977
144Caffeine metabolism_Homo sapiens_hsa002320.42852024
145Endometrial cancer_Homo sapiens_hsa052130.42797195
146Complement and coagulation cascades_Homo sapiens_hsa046100.42787873
147Non-small cell lung cancer_Homo sapiens_hsa052230.41439160

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