

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive thymic T cell selection (GO:0045059) | 7.42606290 |
| 2 | cellular response to interleukin-15 (GO:0071350) | 7.38590243 |
| 3 | negative thymic T cell selection (GO:0045060) | 6.95373652 |
| 4 | response to interleukin-15 (GO:0070672) | 6.91866297 |
| 5 | positive regulation of gamma-delta T cell activation (GO:0046645) | 6.74645474 |
| 6 | negative T cell selection (GO:0043383) | 6.70704181 |
| 7 | negative regulation of cell killing (GO:0031342) | 6.60662076 |
| 8 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.60662076 |
| 9 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 6.45125765 |
| 10 | leukocyte aggregation (GO:0070486) | 6.41202568 |
| 11 | thymic T cell selection (GO:0045061) | 6.36272298 |
| 12 | regulation of T cell tolerance induction (GO:0002664) | 6.04634859 |
| 13 | interferon-gamma production (GO:0032609) | 5.98874068 |
| 14 | regulation of natural killer cell mediated immunity (GO:0002715) | 5.82818937 |
| 15 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 5.82818937 |
| 16 | regulation of gamma-delta T cell differentiation (GO:0045586) | 5.80629913 |
| 17 | positive T cell selection (GO:0043368) | 5.74836315 |
| 18 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.54199239 |
| 19 | sequestering of actin monomers (GO:0042989) | 5.41715869 |
| 20 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 5.33333904 |
| 21 | T cell costimulation (GO:0031295) | 5.28308565 |
| 22 | regulation of isotype switching to IgG isotypes (GO:0048302) | 5.24155662 |
| 23 | lymphocyte costimulation (GO:0031294) | 5.23578099 |
| 24 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 5.20939009 |
| 25 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 5.20939009 |
| 26 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 5.17487730 |
| 27 | regulation of gamma-delta T cell activation (GO:0046643) | 5.16834577 |
| 28 | T cell selection (GO:0045058) | 5.16224093 |
| 29 | T cell migration (GO:0072678) | 5.14473108 |
| 30 | positive regulation of tolerance induction (GO:0002645) | 5.11744639 |
| 31 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 4.75876618 |
| 32 | T cell receptor signaling pathway (GO:0050852) | 4.53570638 |
| 33 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.52519869 |
| 34 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.52519869 |
| 35 | regulation of tolerance induction (GO:0002643) | 4.49313501 |
| 36 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 4.46215058 |
| 37 | regulation of monocyte differentiation (GO:0045655) | 4.31816183 |
| 38 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.30578971 |
| 39 | cellular extravasation (GO:0045123) | 4.26699807 |
| 40 | regulation of cell killing (GO:0031341) | 4.26217997 |
| 41 | positive regulation of B cell differentiation (GO:0045579) | 4.25216536 |
| 42 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.19375052 |
| 43 | tolerance induction (GO:0002507) | 4.13524020 |
| 44 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 4.13465567 |
| 45 | regulation of response to interferon-gamma (GO:0060330) | 4.10553517 |
| 46 | cytidine deamination (GO:0009972) | 4.07087864 |
| 47 | cytidine metabolic process (GO:0046087) | 4.07087864 |
| 48 | cytidine catabolic process (GO:0006216) | 4.07087864 |
| 49 | natural killer cell activation (GO:0030101) | 4.04669357 |
| 50 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.04139585 |
| 51 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 4.00933285 |
| 52 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.98537947 |
| 53 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.92649431 |
| 54 | negative regulation of T cell mediated immunity (GO:0002710) | 3.91223457 |
| 55 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.87691454 |
| 56 | cellular defense response (GO:0006968) | 3.87650388 |
| 57 | positive regulation of cell killing (GO:0031343) | 3.86003222 |
| 58 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.82872033 |
| 59 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.82148997 |
| 60 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.77227229 |
| 61 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.74451480 |
| 62 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.73116408 |
| 63 | regulation of B cell mediated immunity (GO:0002712) | 3.72463283 |
| 64 | regulation of B cell differentiation (GO:0045577) | 3.71614690 |
| 65 | positive regulation of lamellipodium assembly (GO:0010592) | 3.69179113 |
| 66 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.67995327 |
| 67 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.65238001 |
| 68 | leukocyte cell-cell adhesion (GO:0007159) | 3.65106638 |
| 69 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.63012362 |
| 70 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.60316060 |
| 71 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.59226669 |
| 72 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.55607785 |
| 73 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.55546625 |
| 74 | positive regulation of B cell mediated immunity (GO:0002714) | 3.55546625 |
| 75 | positive regulation of humoral immune response (GO:0002922) | 3.51718735 |
| 76 | positive regulation of granulocyte differentiation (GO:0030854) | 3.51427446 |
| 77 | heterotypic cell-cell adhesion (GO:0034113) | 3.50202313 |
| 78 | regulation of lymphocyte mediated immunity (GO:0002706) | 3.49013726 |
| 79 | immunoglobulin mediated immune response (GO:0016064) | 3.46050561 |
| 80 | negative regulation of T cell apoptotic process (GO:0070233) | 3.42571890 |
| 81 | regulation of isotype switching (GO:0045191) | 3.41146502 |
| 82 | regulation of regulatory T cell differentiation (GO:0045589) | 3.40279814 |
| 83 | B cell receptor signaling pathway (GO:0050853) | 3.39119251 |
| 84 | mast cell activation (GO:0045576) | 3.38928269 |
| 85 | regulation of activation of Janus kinase activity (GO:0010533) | 3.35274701 |
| 86 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 3.34591618 |
| 87 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.33739307 |
| 88 | positive regulation of macrophage differentiation (GO:0045651) | 3.32617403 |
| 89 | DNA deamination (GO:0045006) | 3.32183210 |
| 90 | positive regulation of lamellipodium organization (GO:1902745) | 3.29784416 |
| 91 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.29600567 |
| 92 | regulation of immunoglobulin production (GO:0002637) | 3.27978953 |
| 93 | B cell mediated immunity (GO:0019724) | 3.27943423 |
| 94 | negative regulation of phagocytosis (GO:0050765) | 3.27896242 |
| 95 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.25784937 |
| 96 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.25467599 |
| 97 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.23980729 |
| 98 | negative regulation of interleukin-12 production (GO:0032695) | 3.22863969 |
| 99 | positive regulation of T cell mediated immunity (GO:0002711) | 3.20595071 |
| 100 | homeostasis of number of cells within a tissue (GO:0048873) | 3.20140534 |
| 101 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 3.19952437 |
| 102 | dendritic cell chemotaxis (GO:0002407) | 3.19795938 |
| 103 | detection of bacterium (GO:0016045) | 3.18804834 |
| 104 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.17222821 |
| 105 | lymphocyte migration (GO:0072676) | 3.16575568 |
| 106 | regulation of T cell mediated immunity (GO:0002709) | 3.16406533 |
| 107 | positive regulation of immune response to tumor cell (GO:0002839) | 3.14511961 |
| 108 | regulation of immune response to tumor cell (GO:0002837) | 3.14511961 |
| 109 | regulation of response to tumor cell (GO:0002834) | 3.14511961 |
| 110 | positive regulation of response to tumor cell (GO:0002836) | 3.14511961 |
| 111 | T cell activation (GO:0042110) | 3.13162035 |
| 112 | neutrophil activation (GO:0042119) | 3.12611007 |
| 113 | negative regulation of viral genome replication (GO:0045071) | 3.12027979 |
| 114 | activated T cell proliferation (GO:0050798) | 3.11863993 |
| 115 | lymph node development (GO:0048535) | 3.11820185 |
| 116 | positive regulation of interleukin-2 production (GO:0032743) | 3.11540634 |
| 117 | regulation of alpha-beta T cell activation (GO:0046634) | 3.11207141 |
| 118 | regulation of defense response to virus by virus (GO:0050690) | 3.10193553 |
| 119 | response to type I interferon (GO:0034340) | 3.10077932 |
| 120 | positive regulation of interleukin-4 production (GO:0032753) | 3.09977539 |
| 121 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 3.09633714 |
| 122 | T cell homeostasis (GO:0043029) | 3.08704981 |
| 123 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.07623007 |
| 124 | type I interferon signaling pathway (GO:0060337) | 3.07523593 |
| 125 | cellular response to type I interferon (GO:0071357) | 3.07523593 |
| 126 | positive regulation of immunoglobulin production (GO:0002639) | 3.06811412 |
| 127 | regulation of interferon-alpha production (GO:0032647) | 3.06055917 |
| 128 | regulation of respiratory burst (GO:0060263) | 3.05826818 |
| 129 | positive regulation of interferon-gamma production (GO:0032729) | 3.04228415 |
| 130 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.03497563 |
| 131 | Peyers patch development (GO:0048541) | 3.03286494 |
| 132 | detection of other organism (GO:0098543) | 3.00887021 |
| 133 | neutrophil activation involved in immune response (GO:0002283) | 2.97288286 |
| 134 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 2.94797010 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 6.08381254 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.67489568 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.24622890 |
| 4 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.15487526 |
| 5 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.08599643 |
| 6 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 4.07324479 |
| 7 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.89979758 |
| 8 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.75494084 |
| 9 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.68239943 |
| 10 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.41747729 |
| 11 | * MYB_26560356_Chip-Seq_TH2_Human | 3.16861827 |
| 12 | * MAF_26560356_Chip-Seq_TH1_Human | 3.12049648 |
| 13 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.06037191 |
| 14 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.01487667 |
| 15 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.86710811 |
| 16 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.83813062 |
| 17 | * MYB_26560356_Chip-Seq_TH1_Human | 2.72704084 |
| 18 | * UTX_26944678_Chip-Seq_JUKART_Human | 2.69769565 |
| 19 | MYC_22102868_ChIP-Seq_BL_Human | 2.62810500 |
| 20 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.44738225 |
| 21 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.41625425 |
| 22 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.34613762 |
| 23 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.27639598 |
| 24 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 2.26105850 |
| 25 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.24411092 |
| 26 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.19339029 |
| 27 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.10779662 |
| 28 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.09084448 |
| 29 | MAF_26560356_Chip-Seq_TH2_Human | 2.04294691 |
| 30 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.01894556 |
| 31 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.99977650 |
| 32 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.98762841 |
| 33 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 1.98280983 |
| 34 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.98148280 |
| 35 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.94907565 |
| 36 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.92765991 |
| 37 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.89887613 |
| 38 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.81621978 |
| 39 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.81509704 |
| 40 | SPI1_23127762_ChIP-Seq_K562_Human | 1.72111151 |
| 41 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.71631246 |
| 42 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.67504702 |
| 43 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.62135468 |
| 44 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.61280032 |
| 45 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.60508212 |
| 46 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.53314790 |
| 47 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.51115486 |
| 48 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.48315749 |
| 49 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.41059072 |
| 50 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.40722297 |
| 51 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.40628187 |
| 52 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.37351138 |
| 53 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.36961359 |
| 54 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.36593077 |
| 55 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.33586798 |
| 56 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.33117426 |
| 57 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.31756896 |
| 58 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.28345164 |
| 59 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.28022811 |
| 60 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.27586260 |
| 61 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.26007101 |
| 62 | GATA3_26560356_Chip-Seq_TH2_Human | 1.25308372 |
| 63 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.25142153 |
| 64 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.24885670 |
| 65 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.23505953 |
| 66 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.22521585 |
| 67 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.22462575 |
| 68 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.21721357 |
| 69 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.20852807 |
| 70 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.20056611 |
| 71 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.19642499 |
| 72 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.17509926 |
| 73 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.16790972 |
| 74 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.16738671 |
| 75 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.16648709 |
| 76 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.13486274 |
| 77 | * P300_27268052_Chip-Seq_Bcells_Human | 1.13374048 |
| 78 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.12783521 |
| 79 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.12482714 |
| 80 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.11320262 |
| 81 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.10530085 |
| 82 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.08636316 |
| 83 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.06718842 |
| 84 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.05573877 |
| 85 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.04193686 |
| 86 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.03832191 |
| 87 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.97419307 |
| 88 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.97399299 |
| 89 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.94495234 |
| 90 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.93463734 |
| 91 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.92326080 |
| 92 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.91626105 |
| 93 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.91558270 |
| 94 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.90716778 |
| 95 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.90260192 |
| 96 | GATA3_26560356_Chip-Seq_TH1_Human | 0.90052641 |
| 97 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.89745292 |
| 98 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.88883728 |
| 99 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.88843033 |
| 100 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.88126680 |
| 101 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.87209873 |
| 102 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.86018696 |
| 103 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.85302679 |
| 104 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.84455962 |
| 105 | GATA1_22025678_ChIP-Seq_K562_Human | 0.83870087 |
| 106 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.83764143 |
| 107 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83553990 |
| 108 | SA1_27219007_Chip-Seq_Bcells_Human | 0.83083314 |
| 109 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.82241874 |
| 110 | * P68_20966046_ChIP-Seq_HELA_Human | 0.81671384 |
| 111 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.80966452 |
| 112 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.80867928 |
| 113 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.80553509 |
| 114 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.78029087 |
| 115 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.76694631 |
| 116 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.74702314 |
| 117 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.74125683 |
| 118 | GATA2_19941826_ChIP-Seq_K562_Human | 0.72008773 |
| 119 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.71266105 |
| 120 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.70491237 |
| 121 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.69437835 |
| 122 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.68793260 |
| 123 | GATA1_19941826_ChIP-Seq_K562_Human | 0.68775774 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 6.10483109 |
| 2 | MP0003763_abnormal_thymus_physiology | 4.05987644 |
| 3 | MP0006082_CNS_inflammation | 3.89761476 |
| 4 | MP0001835_abnormal_antigen_presentation | 3.73022367 |
| 5 | MP0009785_altered_susceptibility_to | 3.62806653 |
| 6 | MP0003724_increased_susceptibility_to | 3.25758104 |
| 7 | MP0001800_abnormal_humoral_immune | 3.24902953 |
| 8 | MP0000685_abnormal_immune_system | 3.10509237 |
| 9 | MP0005000_abnormal_immune_tolerance | 3.03856561 |
| 10 | MP0005025_abnormal_response_to | 2.97067016 |
| 11 | MP0005387_immune_system_phenotype | 2.94361586 |
| 12 | MP0001790_abnormal_immune_system | 2.94361586 |
| 13 | MP0002420_abnormal_adaptive_immunity | 2.87717167 |
| 14 | MP0002723_abnormal_immune_serum | 2.86344056 |
| 15 | MP0001819_abnormal_immune_cell | 2.85494209 |
| 16 | MP0002166_altered_tumor_susceptibility | 2.78660071 |
| 17 | MP0002452_abnormal_antigen_presenting | 2.59449860 |
| 18 | MP0002398_abnormal_bone_marrow | 2.49269985 |
| 19 | MP0004947_skin_inflammation | 2.48931059 |
| 20 | MP0002933_joint_inflammation | 2.39456569 |
| 21 | MP0002405_respiratory_system_inflammati | 2.37074980 |
| 22 | MP0000716_abnormal_immune_system | 2.33567855 |
| 23 | MP0003300_gastrointestinal_ulcer | 2.28085759 |
| 24 | MP0002419_abnormal_innate_immunity | 2.27727541 |
| 25 | MP0002006_tumorigenesis | 2.19922621 |
| 26 | MP0010155_abnormal_intestine_physiology | 2.19390862 |
| 27 | MP0001873_stomach_inflammation | 2.17486483 |
| 28 | MP0002722_abnormal_immune_system | 2.16170629 |
| 29 | MP0009333_abnormal_splenocyte_physiolog | 2.11551013 |
| 30 | MP0000703_abnormal_thymus_morphology | 2.08960164 |
| 31 | MP0003436_decreased_susceptibility_to | 2.04976170 |
| 32 | MP0005464_abnormal_platelet_physiology | 2.00897877 |
| 33 | MP0000689_abnormal_spleen_morphology | 1.96691996 |
| 34 | MP0002429_abnormal_blood_cell | 1.86260144 |
| 35 | MP0001845_abnormal_inflammatory_respons | 1.85486682 |
| 36 | MP0001986_abnormal_taste_sensitivity | 1.82716736 |
| 37 | MP0000858_altered_metastatic_potential | 1.80773273 |
| 38 | MP0002148_abnormal_hypersensitivity_rea | 1.71992270 |
| 39 | MP0003303_peritoneal_inflammation | 1.66517193 |
| 40 | MP0003448_altered_tumor_morphology | 1.64950221 |
| 41 | MP0008469_abnormal_protein_level | 1.53943461 |
| 42 | MP0001851_eye_inflammation | 1.53788938 |
| 43 | MP0004510_myositis | 1.52179955 |
| 44 | MP0003866_abnormal_defecation | 1.48867723 |
| 45 | MP0001533_abnormal_skeleton_physiology | 1.43619557 |
| 46 | MP0005310_abnormal_salivary_gland | 1.42690821 |
| 47 | MP0001853_heart_inflammation | 1.36617607 |
| 48 | MP0002998_abnormal_bone_remodeling | 1.31292708 |
| 49 | MP0002396_abnormal_hematopoietic_system | 1.26032088 |
| 50 | MP0003045_fibrosis | 1.21762326 |
| 51 | MP0000343_altered_response_to | 1.16933012 |
| 52 | MP0009763_increased_sensitivity_to | 1.16647456 |
| 53 | MP0009840_abnormal_foam_cell | 1.14341943 |
| 54 | MP0002277_abnormal_respiratory_mucosa | 1.12150288 |
| 55 | MP0002653_abnormal_ependyma_morphology | 1.10435654 |
| 56 | MP0000465_gastrointestinal_hemorrhage | 1.05896217 |
| 57 | MP0001348_abnormal_lacrimal_gland | 1.03517393 |
| 58 | MP0005360_urolithiasis | 1.03319032 |
| 59 | MP0005023_abnormal_wound_healing | 1.01358614 |
| 60 | MP0010234_abnormal_vibrissa_follicle | 0.98940293 |
| 61 | MP0003172_abnormal_lysosome_physiology | 0.94976155 |
| 62 | MP0002163_abnormal_gland_morphology | 0.91075299 |
| 63 | MP0000490_abnormal_crypts_of | 0.90293398 |
| 64 | MP0000604_amyloidosis | 0.89040488 |
| 65 | MP0000609_abnormal_liver_physiology | 0.88972820 |
| 66 | MP0002693_abnormal_pancreas_physiology | 0.88579572 |
| 67 | MP0005058_abnormal_lysosome_morphology | 0.87262873 |
| 68 | MP0004130_abnormal_muscle_cell | 0.87154551 |
| 69 | MP0002019_abnormal_tumor_incidence | 0.85505810 |
| 70 | MP0005083_abnormal_biliary_tract | 0.84587717 |
| 71 | MP0003183_abnormal_peptide_metabolism | 0.81681379 |
| 72 | MP0004381_abnormal_hair_follicle | 0.75217818 |
| 73 | MP0002132_abnormal_respiratory_system | 0.74820651 |
| 74 | MP0004808_abnormal_hematopoietic_stem | 0.73572772 |
| 75 | MP0006054_spinal_hemorrhage | 0.72744034 |
| 76 | MP0003191_abnormal_cellular_cholesterol | 0.70313191 |
| 77 | MP0009764_decreased_sensitivity_to | 0.70233416 |
| 78 | MP0000249_abnormal_blood_vessel | 0.67882438 |
| 79 | MP0005166_decreased_susceptibility_to | 0.66540677 |
| 80 | MP0005076_abnormal_cell_differentiation | 0.64955275 |
| 81 | MP0005075_abnormal_melanosome_morpholog | 0.64486327 |
| 82 | MP0003795_abnormal_bone_structure | 0.64413647 |
| 83 | MP0003075_altered_response_to | 0.64029791 |
| 84 | MP0005085_abnormal_gallbladder_physiolo | 0.63514527 |
| 85 | MP0005365_abnormal_bile_salt | 0.62372535 |
| 86 | MP0009765_abnormal_xenobiotic_induced | 0.61890229 |
| 87 | MP0001919_abnormal_reproductive_system | 0.61712688 |
| 88 | MP0002136_abnormal_kidney_physiology | 0.59820031 |
| 89 | MP0000477_abnormal_intestine_morphology | 0.59534265 |
| 90 | MP0010329_abnormal_lipoprotein_level | 0.58739712 |
| 91 | MP0003806_abnormal_nucleotide_metabolis | 0.56619546 |
| 92 | MP0003646_muscle_fatigue | 0.56338658 |
| 93 | MP0001191_abnormal_skin_condition | 0.56141220 |
| 94 | MP0001881_abnormal_mammary_gland | 0.55904525 |
| 95 | MP0002009_preneoplasia | 0.55457334 |
| 96 | MP0005390_skeleton_phenotype | 0.55261360 |
| 97 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.54572701 |
| 98 | MP0003566_abnormal_cell_adhesion | 0.53569172 |
| 99 | MP0002139_abnormal_hepatobiliary_system | 0.53465169 |
| 100 | MP0000598_abnormal_liver_morphology | 0.52484544 |
| 101 | MP0004145_abnormal_muscle_electrophysio | 0.52382633 |
| 102 | MP0003252_abnormal_bile_duct | 0.51985199 |
| 103 | MP0002138_abnormal_hepatobiliary_system | 0.51554866 |
| 104 | MP0008873_increased_physiological_sensi | 0.50562878 |
| 105 | MP0001501_abnormal_sleep_pattern | 0.50143441 |
| 106 | MP0000920_abnormal_myelination | 0.49718980 |
| 107 | MP0009643_abnormal_urine_homeostasis | 0.49215806 |
| 108 | MP0003453_abnormal_keratinocyte_physiol | 0.48796545 |
| 109 | MP0008875_abnormal_xenobiotic_pharmacok | 0.48520449 |
| 110 | MP0008872_abnormal_physiological_respon | 0.47566408 |
| 111 | MP0009278_abnormal_bone_marrow | 0.47556404 |
| 112 | MP0001663_abnormal_digestive_system | 0.45504626 |
| 113 | MP0003329_amyloid_beta_deposits | 0.45193592 |
| 114 | MP0010307_abnormal_tumor_latency | 0.44355683 |
| 115 | MP0005174_abnormal_tail_pigmentation | 0.43879865 |
| 116 | MP0001765_abnormal_ion_homeostasis | 0.42498062 |
| 117 | MP0008961_abnormal_basal_metabolism | 0.42448281 |
| 118 | MP0005645_abnormal_hypothalamus_physiol | 0.42154192 |
| 119 | MP0003279_aneurysm | 0.41146131 |
| 120 | MP0001764_abnormal_homeostasis | 0.40411196 |
| 121 | MP0002254_reproductive_system_inflammat | 0.37640942 |
| 122 | MP0009642_abnormal_blood_homeostasis | 0.37513937 |
| 123 | MP0008877_abnormal_DNA_methylation | 0.37443662 |
| 124 | MP0004883_abnormal_blood_vessel | 0.36843404 |
| 125 | MP0005381_digestive/alimentary_phenotyp | 0.34024740 |
| 126 | MP0002083_premature_death | 0.33505144 |
| 127 | MP0008874_decreased_physiological_sensi | 0.33113666 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Optic neuritis (HP:0100653) | 6.19116956 |
| 2 | Retrobulbar optic neuritis (HP:0100654) | 6.19116956 |
| 3 | Myositis (HP:0100614) | 6.14403342 |
| 4 | Severe combined immunodeficiency (HP:0004430) | 6.11194939 |
| 5 | Orchitis (HP:0100796) | 5.87678020 |
| 6 | Combined immunodeficiency (HP:0005387) | 5.45995324 |
| 7 | T lymphocytopenia (HP:0005403) | 5.40878638 |
| 8 | Abnormality of T cell number (HP:0011839) | 5.30036786 |
| 9 | Eczematoid dermatitis (HP:0000976) | 4.73517869 |
| 10 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.69891005 |
| 11 | Chronic mucocutaneous candidiasis (HP:0002728) | 4.48459255 |
| 12 | Recurrent cutaneous fungal infections (HP:0011370) | 4.48459255 |
| 13 | Recurrent bronchitis (HP:0002837) | 4.45095866 |
| 14 | Thyroiditis (HP:0100646) | 4.38121836 |
| 15 | Autoimmune hemolytic anemia (HP:0001890) | 4.30041410 |
| 16 | Recurrent abscess formation (HP:0002722) | 4.23588937 |
| 17 | Keratoconjunctivitis sicca (HP:0001097) | 4.19435053 |
| 18 | IgM deficiency (HP:0002850) | 4.13230567 |
| 19 | Recurrent fungal infections (HP:0002841) | 4.07286541 |
| 20 | Stomatitis (HP:0010280) | 3.97132324 |
| 21 | Abnormality of T cells (HP:0002843) | 3.94435352 |
| 22 | Keratoconjunctivitis (HP:0001096) | 3.77572751 |
| 23 | Lymphopenia (HP:0001888) | 3.73484301 |
| 24 | Pulmonary infiltrates (HP:0002113) | 3.72588268 |
| 25 | IgG deficiency (HP:0004315) | 3.70739822 |
| 26 | Hypoplasia of the thymus (HP:0000778) | 3.65891185 |
| 27 | Chronic diarrhea (HP:0002028) | 3.62943520 |
| 28 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.61563695 |
| 29 | Hemoptysis (HP:0002105) | 3.61274753 |
| 30 | Meningitis (HP:0001287) | 3.60140687 |
| 31 | Chronic obstructive pulmonary disease (HP:0006510) | 3.53205914 |
| 32 | Obstructive lung disease (HP:0006536) | 3.53205914 |
| 33 | Granulocytopenia (HP:0001913) | 3.51223309 |
| 34 | Abnormality of eosinophils (HP:0001879) | 3.48451147 |
| 35 | Nasal polyposis (HP:0100582) | 3.47383310 |
| 36 | Pulmonary embolism (HP:0002204) | 3.40567169 |
| 37 | Vasculitis (HP:0002633) | 3.38601507 |
| 38 | Gangrene (HP:0100758) | 3.36249476 |
| 39 | Arterial thrombosis (HP:0004420) | 3.36062203 |
| 40 | Leukocytosis (HP:0001974) | 3.32157885 |
| 41 | Joint swelling (HP:0001386) | 3.31594903 |
| 42 | Recurrent skin infections (HP:0001581) | 3.29135111 |
| 43 | Encephalitis (HP:0002383) | 3.23414060 |
| 44 | Increased IgE level (HP:0003212) | 3.20275091 |
| 45 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.14367576 |
| 46 | Panhypogammaglobulinemia (HP:0003139) | 2.97643005 |
| 47 | Agammaglobulinemia (HP:0004432) | 2.95427756 |
| 48 | Abnormality of the prostate (HP:0008775) | 2.88838632 |
| 49 | Aplastic anemia (HP:0001915) | 2.88007893 |
| 50 | Abnormality of the nasal mucosa (HP:0000433) | 2.87345474 |
| 51 | Gingivitis (HP:0000230) | 2.75539433 |
| 52 | Recurrent bacterial skin infections (HP:0005406) | 2.75313508 |
| 53 | Verrucae (HP:0200043) | 2.75288773 |
| 54 | Papilloma (HP:0012740) | 2.75288773 |
| 55 | Mediastinal lymphadenopathy (HP:0100721) | 2.73416366 |
| 56 | Hypochromic anemia (HP:0001931) | 2.72341308 |
| 57 | Recurrent viral infections (HP:0004429) | 2.71245572 |
| 58 | Recurrent sinusitis (HP:0011108) | 2.69730675 |
| 59 | Gastrointestinal stroma tumor (HP:0100723) | 2.69614091 |
| 60 | Increased IgM level (HP:0003496) | 2.69244698 |
| 61 | Abnormality of T cell physiology (HP:0011840) | 2.63387384 |
| 62 | Autoimmune thrombocytopenia (HP:0001973) | 2.63047436 |
| 63 | Anorexia (HP:0002039) | 2.61085239 |
| 64 | Abnormality of B cell number (HP:0010975) | 2.57064865 |
| 65 | B lymphocytopenia (HP:0010976) | 2.57064865 |
| 66 | Sepsis (HP:0100806) | 2.56397582 |
| 67 | Ureteral stenosis (HP:0000071) | 2.51015286 |
| 68 | Abnormality of the pleura (HP:0002103) | 2.50601435 |
| 69 | Systemic lupus erythematosus (HP:0002725) | 2.47593966 |
| 70 | Chronic otitis media (HP:0000389) | 2.47378183 |
| 71 | Gastrointestinal infarctions (HP:0005244) | 2.45581615 |
| 72 | Polyneuropathy (HP:0001271) | 2.40412036 |
| 73 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.39407444 |
| 74 | Inflammation of the large intestine (HP:0002037) | 2.39375744 |
| 75 | Cellulitis (HP:0100658) | 2.39160254 |
| 76 | Glomerulopathy (HP:0100820) | 2.35995819 |
| 77 | Thrombophlebitis (HP:0004418) | 2.33718633 |
| 78 | Abnormality of the pericardium (HP:0001697) | 2.33612302 |
| 79 | Bronchitis (HP:0012387) | 2.33167762 |
| 80 | Abnormality of macrophages (HP:0004311) | 2.30932927 |
| 81 | Ureteral obstruction (HP:0006000) | 2.30763367 |
| 82 | Hypochromic microcytic anemia (HP:0004840) | 2.29401657 |
| 83 | Keratitis (HP:0000491) | 2.29181776 |
| 84 | Chronic sinusitis (HP:0011109) | 2.27524719 |
| 85 | Recurrent otitis media (HP:0000403) | 2.26192360 |
| 86 | Pustule (HP:0200039) | 2.26036429 |
| 87 | Gastrointestinal inflammation (HP:0004386) | 2.23150895 |
| 88 | Prolonged bleeding time (HP:0003010) | 2.22994843 |
| 89 | Petechiae (HP:0000967) | 2.21547159 |
| 90 | Hemiplegia (HP:0002301) | 2.20209650 |
| 91 | Epistaxis (HP:0000421) | 2.17541987 |
| 92 | Hypergammaglobulinemia (HP:0010702) | 2.14075991 |
| 93 | Eosinophilia (HP:0001880) | 2.13031109 |
| 94 | Stomach cancer (HP:0012126) | 2.12243890 |
| 95 | Colitis (HP:0002583) | 2.11467838 |
| 96 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.09615080 |
| 97 | Hypoproteinemia (HP:0003075) | 2.08124102 |
| 98 | Chest pain (HP:0100749) | 2.06641334 |
| 99 | Increased cerebral lipofuscin (HP:0011813) | 2.02887852 |
| 100 | Abnormality of the endocardium (HP:0004306) | 2.02742331 |
| 101 | IgA deficiency (HP:0002720) | 1.99864451 |
| 102 | Gingival bleeding (HP:0000225) | 1.99037561 |
| 103 | Osteomyelitis (HP:0002754) | 1.98675447 |
| 104 | Recurrent pneumonia (HP:0006532) | 1.97614349 |
| 105 | Periodontitis (HP:0000704) | 1.96507939 |
| 106 | Spontaneous hematomas (HP:0007420) | 1.95072864 |
| 107 | Arthralgia (HP:0002829) | 1.93863973 |
| 108 | Skin rash (HP:0000988) | 1.92554493 |
| 109 | Abnormality of the common coagulation pathway (HP:0010990) | 1.91790651 |
| 110 | Purpura (HP:0000979) | 1.91041126 |
| 111 | Entropion (HP:0000621) | 1.90501569 |
| 112 | Microcytic anemia (HP:0001935) | 1.88500661 |
| 113 | Increased serum ferritin (HP:0003281) | 1.86651776 |
| 114 | Urticaria (HP:0001025) | 1.83722391 |
| 115 | Lymphoma (HP:0002665) | 1.83622583 |
| 116 | Acute hepatic failure (HP:0006554) | 1.81674381 |
| 117 | Recurrent lower respiratory tract infections (HP:0002783) | 1.81082828 |
| 118 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.80159421 |
| 119 | Abnormal albumin level (HP:0012116) | 1.78670046 |
| 120 | Hypoalbuminemia (HP:0003073) | 1.78670046 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 8.15923763 |
| 2 | MAP4K1 | 4.22989903 |
| 3 | KDR | 3.53408816 |
| 4 | IKBKE | 3.26706928 |
| 5 | FGFR4 | 3.21653909 |
| 6 | PASK | 3.15470614 |
| 7 | JAK1 | 3.08211266 |
| 8 | RIPK4 | 2.99019314 |
| 9 | ZAP70 | 2.91223540 |
| 10 | TYK2 | 2.90505184 |
| 11 | ITK | 2.81139106 |
| 12 | TBK1 | 2.68748516 |
| 13 | TESK2 | 2.19562529 |
| 14 | JAK3 | 2.18540540 |
| 15 | CAMKK1 | 2.03059735 |
| 16 | LCK | 2.01680456 |
| 17 | KIT | 1.92863310 |
| 18 | BLK | 1.74626104 |
| 19 | FGFR3 | 1.71131113 |
| 20 | CAMKK2 | 1.62704210 |
| 21 | MAP3K12 | 1.61142055 |
| 22 | TEC | 1.48100015 |
| 23 | MAP3K14 | 1.47555719 |
| 24 | HCK | 1.45221023 |
| 25 | STK10 | 1.44317032 |
| 26 | SYK | 1.43258788 |
| 27 | GRK6 | 1.42236348 |
| 28 | CSK | 1.39292410 |
| 29 | TAOK3 | 1.39082998 |
| 30 | ERN1 | 1.37223460 |
| 31 | BTK | 1.32117631 |
| 32 | PRKCH | 1.21101260 |
| 33 | PRPF4B | 1.12443119 |
| 34 | MAP2K6 | 1.11837844 |
| 35 | NEK9 | 1.10198591 |
| 36 | TAOK1 | 1.06088463 |
| 37 | FES | 1.05317893 |
| 38 | IKBKB | 1.02813339 |
| 39 | LYN | 0.99883541 |
| 40 | JAK2 | 0.92883251 |
| 41 | IRAK4 | 0.92833090 |
| 42 | PRKCQ | 0.92348909 |
| 43 | TLK1 | 0.92055563 |
| 44 | BMPR2 | 0.91782483 |
| 45 | TESK1 | 0.87000140 |
| 46 | IRAK3 | 0.85087817 |
| 47 | MAP3K13 | 0.84626094 |
| 48 | TGFBR2 | 0.82521931 |
| 49 | MAPK11 | 0.81583955 |
| 50 | CSF1R | 0.80584076 |
| 51 | FGFR1 | 0.79691089 |
| 52 | FYN | 0.79403761 |
| 53 | EPHB1 | 0.77742673 |
| 54 | GRK7 | 0.75193328 |
| 55 | DMPK | 0.72855317 |
| 56 | IGF1R | 0.70768686 |
| 57 | SIK2 | 0.70671549 |
| 58 | LRRK2 | 0.68618082 |
| 59 | TRIB3 | 0.68184753 |
| 60 | DAPK2 | 0.67826397 |
| 61 | TNK2 | 0.66876024 |
| 62 | SIK1 | 0.66364788 |
| 63 | NME2 | 0.64581549 |
| 64 | PKN2 | 0.63273927 |
| 65 | PIK3CG | 0.59442422 |
| 66 | INSR | 0.57593216 |
| 67 | TYRO3 | 0.56258932 |
| 68 | MAP2K2 | 0.52661290 |
| 69 | MAP3K11 | 0.52339996 |
| 70 | MAPKAPK3 | 0.49231729 |
| 71 | STK24 | 0.48719573 |
| 72 | CDK19 | 0.48205652 |
| 73 | CDK9 | 0.47577814 |
| 74 | MAPK7 | 0.45901183 |
| 75 | MAP3K10 | 0.45668491 |
| 76 | MAP3K3 | 0.43463981 |
| 77 | MST4 | 0.40863116 |
| 78 | ADRBK2 | 0.40811489 |
| 79 | STK38 | 0.40300190 |
| 80 | ZAK | 0.40182237 |
| 81 | HIPK2 | 0.39530146 |
| 82 | SCYL2 | 0.39268284 |
| 83 | MYLK | 0.39150290 |
| 84 | VRK1 | 0.38782127 |
| 85 | DAPK3 | 0.37804882 |
| 86 | MAPKAPK2 | 0.37739970 |
| 87 | PAK4 | 0.37400147 |
| 88 | RPS6KA5 | 0.36738636 |
| 89 | PDK1 | 0.36667166 |
| 90 | SMG1 | 0.36171764 |
| 91 | CLK1 | 0.36025095 |
| 92 | LIMK1 | 0.35854039 |
| 93 | PRKCD | 0.35694179 |
| 94 | PIM1 | 0.34124114 |
| 95 | MAPK12 | 0.33398790 |
| 96 | CHUK | 0.32846800 |
| 97 | MAP2K3 | 0.32790984 |
| 98 | EEF2K | 0.32483821 |
| 99 | GRK1 | 0.32134945 |
| 100 | TAOK2 | 0.29861231 |
| 101 | CDK4 | 0.29718552 |
| 102 | STK11 | 0.29027281 |
| 103 | PDGFRB | 0.29015646 |
| 104 | MAP4K2 | 0.25965492 |
| 105 | MAP3K7 | 0.24784553 |
| 106 | NLK | 0.24680417 |
| 107 | PDPK1 | 0.24539766 |
| 108 | ILK | 0.24310953 |
| 109 | TTN | 0.24285650 |
| 110 | PRKD2 | 0.24204244 |
| 111 | SRC | 0.23940665 |
| 112 | GSK3A | 0.23921906 |
| 113 | PTK6 | 0.22836256 |
| 114 | MAPK4 | 0.22606114 |
| 115 | ABL1 | 0.22415269 |
| 116 | EPHA3 | 0.21900192 |
| 117 | RPS6KA4 | 0.21450667 |
| 118 | MAPK3 | 0.21398216 |
| 119 | MARK3 | 0.21348399 |
| 120 | CDK6 | 0.20813253 |
| 121 | MAPK15 | 0.20500538 |
| 122 | ALK | 0.20398846 |
| 123 | SIK3 | 0.20264347 |
| 124 | ACVR1B | 0.19876440 |
| 125 | MAP3K5 | 0.19790457 |
| 126 | EGFR | 0.19531747 |
| 127 | MARK2 | 0.19157901 |
| 128 | FGR | 0.18688518 |
| 129 | DAPK1 | 0.17182116 |
| 130 | MAP3K1 | 0.16201479 |
| 131 | YES1 | 0.15343904 |
| 132 | PRKCZ | 0.12447564 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 5.76550455 |
| 2 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 4.12665555 |
| 3 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 4.07958024 |
| 4 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.57680363 |
| 5 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 3.49783541 |
| 6 | Antigen processing and presentation_Homo sapiens_hsa04612 | 3.26060518 |
| 7 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.98859532 |
| 8 | Measles_Homo sapiens_hsa05162 | 2.88236928 |
| 9 | Allograft rejection_Homo sapiens_hsa05330 | 2.84237259 |
| 10 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.76661137 |
| 11 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.53292960 |
| 12 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.52707546 |
| 13 | Leishmaniasis_Homo sapiens_hsa05140 | 2.33555447 |
| 14 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.08306499 |
| 15 | Asthma_Homo sapiens_hsa05310 | 1.94590396 |
| 16 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.89338392 |
| 17 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.84733232 |
| 18 | Viral myocarditis_Homo sapiens_hsa05416 | 1.82888591 |
| 19 | Other glycan degradation_Homo sapiens_hsa00511 | 1.64678715 |
| 20 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.62146342 |
| 21 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.57341057 |
| 22 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.55743311 |
| 23 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.49968069 |
| 24 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.47524473 |
| 25 | Malaria_Homo sapiens_hsa05144 | 1.46252424 |
| 26 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.38637919 |
| 27 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.36629081 |
| 28 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.32705619 |
| 29 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.30607962 |
| 30 | Apoptosis_Homo sapiens_hsa04210 | 1.15074445 |
| 31 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.13656817 |
| 32 | Shigellosis_Homo sapiens_hsa05131 | 1.11496743 |
| 33 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.09679058 |
| 34 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.07403666 |
| 35 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.02976683 |
| 36 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.01258006 |
| 37 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.01187672 |
| 38 | Lysosome_Homo sapiens_hsa04142 | 0.96693064 |
| 39 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.94568922 |
| 40 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.92186435 |
| 41 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.90574447 |
| 42 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.88045075 |
| 43 | Hepatitis B_Homo sapiens_hsa05161 | 0.86033853 |
| 44 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.85066135 |
| 45 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.77814399 |
| 46 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.75862212 |
| 47 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.75139204 |
| 48 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.74458729 |
| 49 | Tuberculosis_Homo sapiens_hsa05152 | 0.73846280 |
| 50 | Pertussis_Homo sapiens_hsa05133 | 0.73357464 |
| 51 | HTLV-I infection_Homo sapiens_hsa05166 | 0.72511050 |
| 52 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.72460918 |
| 53 | Legionellosis_Homo sapiens_hsa05134 | 0.71070498 |
| 54 | Influenza A_Homo sapiens_hsa05164 | 0.70179307 |
| 55 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.68052971 |
| 56 | Platelet activation_Homo sapiens_hsa04611 | 0.65634709 |
| 57 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.55507506 |
| 58 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.54151457 |
| 59 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.52380363 |
| 60 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.52224793 |
| 61 | Salmonella infection_Homo sapiens_hsa05132 | 0.50899124 |
| 62 | Sulfur relay system_Homo sapiens_hsa04122 | 0.50728981 |
| 63 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.50058603 |
| 64 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.47612962 |
| 65 | Endocytosis_Homo sapiens_hsa04144 | 0.45979309 |
| 66 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.45700167 |
| 67 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.45096506 |
| 68 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.44649342 |
| 69 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.37736451 |
| 70 | Hepatitis C_Homo sapiens_hsa05160 | 0.36168685 |
| 71 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.35954827 |
| 72 | Alcoholism_Homo sapiens_hsa05034 | 0.35590976 |
| 73 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.34870180 |
| 74 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.31961058 |
| 75 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.30892395 |
| 76 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.30607767 |
| 77 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.28744437 |
| 78 | Phototransduction_Homo sapiens_hsa04744 | 0.27967912 |
| 79 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.25931539 |
| 80 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.25329058 |
| 81 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.24550932 |
| 82 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.24436252 |
| 83 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.24047681 |
| 84 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.23284628 |
| 85 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.22184674 |
| 86 | Insulin resistance_Homo sapiens_hsa04931 | 0.22069597 |
| 87 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.21042349 |
| 88 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.20433162 |
| 89 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.20227213 |
| 90 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.19993488 |
| 91 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.19679668 |
| 92 | Colorectal cancer_Homo sapiens_hsa05210 | 0.19319040 |
| 93 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.19311656 |
| 94 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.19047297 |
| 95 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.17844626 |
| 96 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.17096862 |
| 97 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.16435821 |
| 98 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.16267687 |
| 99 | ABC transporters_Homo sapiens_hsa02010 | 0.14875892 |
| 100 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.14680595 |
| 101 | Proteasome_Homo sapiens_hsa03050 | 0.14589072 |
| 102 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.13077787 |
| 103 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.13055612 |
| 104 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.13044538 |
| 105 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.12580394 |
| 106 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.12227845 |
| 107 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.11380519 |
| 108 | Olfactory transduction_Homo sapiens_hsa04740 | 0.11346196 |
| 109 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.11139212 |
| 110 | Long-term potentiation_Homo sapiens_hsa04720 | 0.10671469 |
| 111 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.10275636 |
| 112 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.10210441 |
| 113 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.10056996 |
| 114 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.09754105 |
| 115 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.07412723 |
| 116 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.07364757 |
| 117 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.07154694 |
| 118 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.05603124 |
| 119 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.05446936 |
| 120 | Ribosome_Homo sapiens_hsa03010 | 0.04128869 |
| 121 | Phagosome_Homo sapiens_hsa04145 | 0.03978451 |
| 122 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.03301216 |
| 123 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.03047445 |
| 124 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.02935095 |
| 125 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.02841951 |
| 126 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.02509183 |
| 127 | Amoebiasis_Homo sapiens_hsa05146 | 0.02444624 |

