PWP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.87757323
2nucleobase biosynthetic process (GO:0046112)4.79537052
3purine nucleobase biosynthetic process (GO:0009113)4.70303476
4formation of translation preinitiation complex (GO:0001731)4.66213569
5maturation of SSU-rRNA (GO:0030490)4.60349757
6ribosome assembly (GO:0042255)4.50173770
7DNA strand elongation involved in DNA replication (GO:0006271)4.40260537
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.38499489
9DNA replication initiation (GO:0006270)4.35338811
10ribosome biogenesis (GO:0042254)4.29395113
11mitotic metaphase plate congression (GO:0007080)4.27383119
12protein localization to kinetochore (GO:0034501)4.22033754
13DNA strand elongation (GO:0022616)4.20862400
14establishment of integrated proviral latency (GO:0075713)4.19583506
15IMP biosynthetic process (GO:0006188)4.16804313
16chaperone-mediated protein transport (GO:0072321)4.10829666
17DNA unwinding involved in DNA replication (GO:0006268)4.07034092
18DNA replication checkpoint (GO:0000076)4.06856634
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.06066787
20ATP synthesis coupled proton transport (GO:0015986)4.06066787
21telomere maintenance via semi-conservative replication (GO:0032201)4.04856168
22ribosomal small subunit assembly (GO:0000028)4.02743028
23ribosomal large subunit biogenesis (GO:0042273)3.99087024
24ribonucleoprotein complex biogenesis (GO:0022613)3.93300130
25cullin deneddylation (GO:0010388)3.88581620
26mitotic nuclear envelope disassembly (GO:0007077)3.83498712
27folic acid-containing compound biosynthetic process (GO:0009396)3.68542672
28IMP metabolic process (GO:0046040)3.67571762
29regulation of cellular amino acid metabolic process (GO:0006521)3.66550529
30metaphase plate congression (GO:0051310)3.64720226
31telomere maintenance via recombination (GO:0000722)3.64527243
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.63096191
33proteasome assembly (GO:0043248)3.60706560
34DNA deamination (GO:0045006)3.59024699
35CENP-A containing nucleosome assembly (GO:0034080)3.59014370
36establishment of viral latency (GO:0019043)3.56275684
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.55886615
38nuclear envelope disassembly (GO:0051081)3.55753797
39membrane disassembly (GO:0030397)3.55753797
40protein deneddylation (GO:0000338)3.55245065
41DNA replication-dependent nucleosome organization (GO:0034723)3.55207170
42DNA replication-dependent nucleosome assembly (GO:0006335)3.55207170
43spliceosomal snRNP assembly (GO:0000387)3.55044754
44regulation of spindle organization (GO:0090224)3.54270948
45chromatin remodeling at centromere (GO:0031055)3.53766091
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.52852643
47rRNA processing (GO:0006364)3.52712198
48mitotic recombination (GO:0006312)3.51559808
49protein localization to chromosome, centromeric region (GO:0071459)3.50588627
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.47702361
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.47336468
52signal transduction involved in DNA damage checkpoint (GO:0072422)3.45854990
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45560594
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43825093
55rRNA metabolic process (GO:0016072)3.43759144
56signal transduction involved in cell cycle checkpoint (GO:0072395)3.43743870
57pseudouridine synthesis (GO:0001522)3.43058288
58nuclear pore organization (GO:0006999)3.41924036
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41511331
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40848712
61mitochondrial respiratory chain complex I assembly (GO:0032981)3.40848712
62NADH dehydrogenase complex assembly (GO:0010257)3.40848712
63DNA damage response, detection of DNA damage (GO:0042769)3.40459388
64mitochondrial respiratory chain complex assembly (GO:0033108)3.39827900
65DNA double-strand break processing (GO:0000729)3.39369728
66protein complex biogenesis (GO:0070271)3.38857422
67regulation of mitochondrial translation (GO:0070129)3.37447761
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36717057
69regulation of mitotic spindle checkpoint (GO:1903504)3.36717057
70translational initiation (GO:0006413)3.34925411
71translational termination (GO:0006415)3.33693460
72regulation of ubiquitin-protein transferase activity (GO:0051438)3.33331321
73telomere maintenance via telomere lengthening (GO:0010833)3.30009413
74viral transcription (GO:0019083)3.29571384
75mitochondrial RNA metabolic process (GO:0000959)3.29499383
76maturation of 5.8S rRNA (GO:0000460)3.28077262
77DNA replication-independent nucleosome assembly (GO:0006336)3.27249908
78DNA replication-independent nucleosome organization (GO:0034724)3.27249908
79respiratory electron transport chain (GO:0022904)3.24317534
80attachment of spindle microtubules to kinetochore (GO:0008608)3.24283577
81folic acid metabolic process (GO:0046655)3.24282371
82rRNA modification (GO:0000154)3.24102945
83regulation of ligase activity (GO:0051340)3.20314682
84histone mRNA metabolic process (GO:0008334)3.19385725
85protein targeting to mitochondrion (GO:0006626)3.18610872
86rRNA methylation (GO:0031167)3.17705111
87electron transport chain (GO:0022900)3.16595256
88ribosomal small subunit biogenesis (GO:0042274)3.15098607
89establishment of chromosome localization (GO:0051303)3.14607965
90negative regulation of ligase activity (GO:0051352)3.14436723
91negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14436723
92nuclear pore complex assembly (GO:0051292)3.13663092
93G1/S transition of mitotic cell cycle (GO:0000082)3.13573428
94cell cycle G1/S phase transition (GO:0044843)3.13573428
95translational elongation (GO:0006414)3.12522171
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11842795
97DNA catabolic process, exonucleolytic (GO:0000738)3.11503403
98kinetochore organization (GO:0051383)3.08661411
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.08404024
100transcription elongation from RNA polymerase I promoter (GO:0006362)3.08161626
101protein neddylation (GO:0045116)3.08062456
102viral mRNA export from host cell nucleus (GO:0046784)3.07677214
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06586231
1047-methylguanosine mRNA capping (GO:0006370)3.05033694
105histone exchange (GO:0043486)3.03945993
106transcription-coupled nucleotide-excision repair (GO:0006283)3.03648560
107protein localization to mitochondrion (GO:0070585)3.03344726
108spindle checkpoint (GO:0031577)2.99977653
1097-methylguanosine RNA capping (GO:0009452)2.99824731
110RNA capping (GO:0036260)2.99824731
111spliceosomal complex assembly (GO:0000245)2.99378460
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99057660
113negative regulation of chromosome segregation (GO:0051985)2.97239831
114negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97122301
115negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97122301
116negative regulation of sister chromatid segregation (GO:0033046)2.97122301
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.97122301
118regulation of helicase activity (GO:0051095)2.96937307
119regulation of double-strand break repair via homologous recombination (GO:0010569)2.95984478
120establishment of protein localization to mitochondrion (GO:0072655)2.95379796
121termination of RNA polymerase I transcription (GO:0006363)2.95357430
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.94053321
123amino acid activation (GO:0043038)2.93312229
124tRNA aminoacylation (GO:0043039)2.93312229
125translation (GO:0006412)2.92976884
126mitotic spindle assembly checkpoint (GO:0007094)2.92956129
127DNA ligation (GO:0006266)2.92734930
128termination of RNA polymerase III transcription (GO:0006386)2.92510216
129transcription elongation from RNA polymerase III promoter (GO:0006385)2.92510216
130DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92235385
131respiratory chain complex IV assembly (GO:0008535)2.92134150
132spindle assembly checkpoint (GO:0071173)2.92085315
133positive regulation of ligase activity (GO:0051351)2.91823798
134cellular component biogenesis (GO:0044085)2.91590223
135mitotic sister chromatid segregation (GO:0000070)2.91011608
136mitotic chromosome condensation (GO:0007076)2.90762478
137intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89131862
138signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89131862
139positive regulation of chromosome segregation (GO:0051984)2.88986267
140mitotic spindle checkpoint (GO:0071174)2.88950004
141kinetochore assembly (GO:0051382)2.88883812
142signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88789950
143signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88789950
144signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88789950
145signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88389172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.96666473
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.55671667
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71267316
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46213196
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.42488871
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.30173661
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16809510
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.07867473
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.04445962
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01202678
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.00448243
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98091764
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95208017
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84760403
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82213341
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48008021
17VDR_23849224_ChIP-Seq_CD4+_Human2.38427699
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37876013
19XRN2_22483619_ChIP-Seq_HELA_Human2.34376648
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29473214
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28111882
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22806115
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16826923
24AR_21909140_ChIP-Seq_LNCAP_Human2.09763366
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09709227
26FOXP3_21729870_ChIP-Seq_TREG_Human2.07134037
27DCP1A_22483619_ChIP-Seq_HELA_Human2.01542143
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96938087
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95572868
30GABP_19822575_ChIP-Seq_HepG2_Human1.94033874
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93782711
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.93019325
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92707224
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91202172
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.85511729
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85470443
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85383969
38TTF2_22483619_ChIP-Seq_HELA_Human1.83828796
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80345753
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79405997
41ZNF274_21170338_ChIP-Seq_K562_Hela1.77604822
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76283105
43ELK1_19687146_ChIP-ChIP_HELA_Human1.73597821
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71217903
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68427108
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63269794
47EWS_26573619_Chip-Seq_HEK293_Human1.60903001
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60209721
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.59007138
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55444801
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54736520
52CIITA_25753668_ChIP-Seq_RAJI_Human1.54582340
53VDR_22108803_ChIP-Seq_LS180_Human1.53721068
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53474451
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52288462
56FUS_26573619_Chip-Seq_HEK293_Human1.49858510
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48884936
58KDM5A_27292631_Chip-Seq_BREAST_Human1.47251288
59MYC_22102868_ChIP-Seq_BL_Human1.44341963
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41019068
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.39799454
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.38598514
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32960077
64* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32453158
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31095044
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28946193
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25728866
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25474969
69* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24191428
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24135704
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24124627
72* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22940250
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22737546
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21689981
75* TFEB_21752829_ChIP-Seq_HELA_Human1.20706259
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17781990
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17634689
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17060076
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16603372
80IGF1R_20145208_ChIP-Seq_DFB_Human1.12473060
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12204450
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11829098
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07661615
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07419261
85* NANOG_16153702_ChIP-ChIP_HESCs_Human1.06932023
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06274472
87ELK1_22589737_ChIP-Seq_MCF10A_Human1.05712042
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.03795656
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03139218
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02248458
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01886809
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01573465
93* SOX2_16153702_ChIP-ChIP_HESCs_Human1.00435090
94* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99934795
95* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99373420
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98652054
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98273939
98TAF15_26573619_Chip-Seq_HEK293_Human0.97468824
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95536090
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95045618
101* TP63_19390658_ChIP-ChIP_HaCaT_Human0.94194700
102SPI1_23547873_ChIP-Seq_NB4_Human0.93862326
103MYC_18940864_ChIP-ChIP_HL60_Human0.93493516
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92630603
105P300_19829295_ChIP-Seq_ESCs_Human0.92385385
106SALL1_21062744_ChIP-ChIP_HESCs_Human0.92063585
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91886927
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89984493
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87394319
110TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87063219
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86986990
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.86368513
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.85825366
114IRF1_19129219_ChIP-ChIP_H3396_Human0.82643453
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79784502
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79650799
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79153111
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78628596
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78572959
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78539850
121SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78267427
122ELF5_23300383_ChIP-Seq_T47D_Human0.77087429
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75963290
124TP53_22573176_ChIP-Seq_HFKS_Human0.75401814
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74324359
126* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.73247935
127FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71199277
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.66136657
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.65964410
130CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.65892799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.53818605
2MP0010094_abnormal_chromosome_stability4.69267702
3MP0003111_abnormal_nucleus_morphology4.48845733
4MP0004957_abnormal_blastocyst_morpholog4.41333585
5MP0003077_abnormal_cell_cycle4.03172440
6MP0008057_abnormal_DNA_replication3.78808791
7MP0008058_abnormal_DNA_repair3.57242898
8MP0008007_abnormal_cellular_replicative3.23766382
9MP0009697_abnormal_copulation2.72378242
10MP0008932_abnormal_embryonic_tissue2.66783575
11MP0001529_abnormal_vocalization2.54959638
12MP0002396_abnormal_hematopoietic_system2.50691177
13MP0010352_gastrointestinal_tract_polyps2.44119385
14MP0001730_embryonic_growth_arrest2.43715626
15MP0000350_abnormal_cell_proliferation2.38113848
16MP0003123_paternal_imprinting2.34535186
17MP0002102_abnormal_ear_morphology2.16427793
18MP0000372_irregular_coat_pigmentation2.10719524
19MP0003786_premature_aging2.08444319
20MP0006072_abnormal_retinal_apoptosis1.89408041
21MP0008789_abnormal_olfactory_epithelium1.84680576
22MP0003806_abnormal_nucleotide_metabolis1.84584308
23MP0008877_abnormal_DNA_methylation1.83938806
24MP0003718_maternal_effect1.81424081
25MP0009379_abnormal_foot_pigmentation1.73940914
26MP0001672_abnormal_embryogenesis/_devel1.73797427
27MP0005380_embryogenesis_phenotype1.73797427
28MP0001697_abnormal_embryo_size1.73064978
29MP0010307_abnormal_tumor_latency1.71431024
30MP0009333_abnormal_splenocyte_physiolog1.71081739
31MP0000490_abnormal_crypts_of1.70321702
32MP0002080_prenatal_lethality1.61622036
33MP0003984_embryonic_growth_retardation1.57054511
34MP0006035_abnormal_mitochondrial_morpho1.56366400
35MP0002736_abnormal_nociception_after1.55033204
36MP0002088_abnormal_embryonic_growth/wei1.53776192
37MP0000313_abnormal_cell_death1.49126329
38MP0004808_abnormal_hematopoietic_stem1.47856183
39MP0010030_abnormal_orbit_morphology1.47715420
40MP0006036_abnormal_mitochondrial_physio1.45018814
41MP0004197_abnormal_fetal_growth/weight/1.43193462
42MP0002085_abnormal_embryonic_tissue1.42861496
43MP0002019_abnormal_tumor_incidence1.40985371
44MP0005084_abnormal_gallbladder_morpholo1.36597576
45MP0002084_abnormal_developmental_patter1.35220214
46MP0003567_abnormal_fetal_cardiomyocyte1.35030632
47MP0002086_abnormal_extraembryonic_tissu1.32235611
48MP0005499_abnormal_olfactory_system1.29120225
49MP0005394_taste/olfaction_phenotype1.29120225
50MP0003136_yellow_coat_color1.28503431
51MP0002210_abnormal_sex_determination1.27568450
52MP0002233_abnormal_nose_morphology1.25852978
53MP0001293_anophthalmia1.25847598
54MP0002234_abnormal_pharynx_morphology1.24272433
55MP0003763_abnormal_thymus_physiology1.24035300
56MP0001545_abnormal_hematopoietic_system1.19329220
57MP0005397_hematopoietic_system_phenotyp1.19329220
58MP0002751_abnormal_autonomic_nervous1.18732504
59MP0003315_abnormal_perineum_morphology1.14286661
60MP0000049_abnormal_middle_ear1.13352073
61MP0005187_abnormal_penis_morphology1.11009647
62MP0002398_abnormal_bone_marrow1.10893837
63MP0001145_abnormal_male_reproductive1.10395775
64MP0000647_abnormal_sebaceous_gland1.09768467
65MP0005253_abnormal_eye_physiology1.07368555
66MP0003011_delayed_dark_adaptation1.07041902
67MP0001764_abnormal_homeostasis1.06122733
68MP0003186_abnormal_redox_activity1.05901949
69MP0008260_abnormal_autophagy1.05741072
70MP0000689_abnormal_spleen_morphology1.04595194
71MP0000358_abnormal_cell_content/1.04459635
72MP0005551_abnormal_eye_electrophysiolog1.04404306
73MP0002722_abnormal_immune_system1.04120537
74MP0005395_other_phenotype1.03925244
75MP0000703_abnormal_thymus_morphology1.02630455
76MP0000858_altered_metastatic_potential1.01706741
77MP0003890_abnormal_embryonic-extraembry1.01269636
78MP0009053_abnormal_anal_canal0.96049850
79MP0003221_abnormal_cardiomyocyte_apopto0.95612199
80MP0001984_abnormal_olfaction0.94441071
81MP0005076_abnormal_cell_differentiation0.93422719
82MP0003755_abnormal_palate_morphology0.93105604
83MP0003121_genomic_imprinting0.91803552
84MP0000653_abnormal_sex_gland0.90747734
85MP0002638_abnormal_pupillary_reflex0.89469926
86MP0003950_abnormal_plasma_membrane0.89266083
87MP0006292_abnormal_olfactory_placode0.88264384
88MP0002429_abnormal_blood_cell0.87853312
89MP0001929_abnormal_gametogenesis0.87425677
90MP0005023_abnormal_wound_healing0.85776690
91MP0001188_hyperpigmentation0.84874372
92MP0005384_cellular_phenotype0.84786166
93MP0002282_abnormal_trachea_morphology0.84393055
94MP0001968_abnormal_touch/_nociception0.84234012
95MP0003119_abnormal_digestive_system0.84185257
96MP0000762_abnormal_tongue_morphology0.83589953
97MP0008995_early_reproductive_senescence0.81611322
98MP0002111_abnormal_tail_morphology0.80466736
99MP0009672_abnormal_birth_weight0.79774875
100MP0005621_abnormal_cell_physiology0.78539841
101MP0003698_abnormal_male_reproductive0.78200831
102MP0005391_vision/eye_phenotype0.77757370
103MP0000537_abnormal_urethra_morphology0.77162599
104MP0003937_abnormal_limbs/digits/tail_de0.76169764
105MP0001119_abnormal_female_reproductive0.75930889
106MP0000716_abnormal_immune_system0.75867480
107MP0003941_abnormal_skin_development0.75803033
108MP0003448_altered_tumor_morphology0.75704028
109MP0009250_abnormal_appendicular_skeleto0.74704159
110MP0005389_reproductive_system_phenotype0.74419685
111MP0000631_abnormal_neuroendocrine_gland0.72948784
112MP0002132_abnormal_respiratory_system0.72942205
113MP0002160_abnormal_reproductive_system0.72528662
114MP0005410_abnormal_fertilization0.72034126
115MP0009785_altered_susceptibility_to0.71506143
116MP0002095_abnormal_skin_pigmentation0.69781401
117MP0006276_abnormal_autonomic_nervous0.69193962
118MP0001324_abnormal_eye_pigmentation0.67546790
119MP0001905_abnormal_dopamine_level0.67236059
120MP0001853_heart_inflammation0.67098485
121MP0005671_abnormal_response_to0.66318065
122MP0001800_abnormal_humoral_immune0.65738562
123MP0002161_abnormal_fertility/fecundity0.65521027
124MP0003436_decreased_susceptibility_to0.65306444
125MP0003935_abnormal_craniofacial_develop0.64999894
126MP0001286_abnormal_eye_development0.64986848
127MP0002177_abnormal_outer_ear0.64854840
128MP0005195_abnormal_posterior_eye0.64632504
129MP0003385_abnormal_body_wall0.63916162
130MP0002092_abnormal_eye_morphology0.63804187
131MP0000428_abnormal_craniofacial_morphol0.63256638
132MP0002697_abnormal_eye_size0.63116144
133MP0001919_abnormal_reproductive_system0.62766580
134MP0002452_abnormal_antigen_presenting0.61954163
135MP0002420_abnormal_adaptive_immunity0.61506709
136MP0002006_tumorigenesis0.61113723
137MP0001819_abnormal_immune_cell0.60194339
138MP0000465_gastrointestinal_hemorrhage0.56558992
139MP0000477_abnormal_intestine_morphology0.55751323
140MP0002723_abnormal_immune_serum0.55208442
141MP0002405_respiratory_system_inflammati0.54687520
142MP0009703_decreased_birth_body0.53539893
143MP0003566_abnormal_cell_adhesion0.52966958
144MP0002938_white_spotting0.51044563
145MP0004133_heterotaxia0.51044378
146MP0000371_diluted_coat_color0.49969259
147MP0002075_abnormal_coat/hair_pigmentati0.49951162
148MP0005075_abnormal_melanosome_morpholog0.49350902
149MP0005000_abnormal_immune_tolerance0.48387181

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.51903794
2Acute necrotizing encephalopathy (HP:0006965)4.65839474
3Breast hypoplasia (HP:0003187)4.23660922
4Acute encephalopathy (HP:0006846)4.18907996
5Abnormal mitochondria in muscle tissue (HP:0008316)4.10959925
6Increased hepatocellular lipid droplets (HP:0006565)4.09320271
7Mitochondrial inheritance (HP:0001427)3.96961094
8Increased CSF lactate (HP:0002490)3.96087387
9Progressive macrocephaly (HP:0004481)3.88896506
10Lipid accumulation in hepatocytes (HP:0006561)3.69281131
11Abnormality of cells of the erythroid lineage (HP:0012130)3.68067856
12Carpal bone hypoplasia (HP:0001498)3.64284960
13Reticulocytopenia (HP:0001896)3.57330635
14Cerebral hypomyelination (HP:0006808)3.53639102
15Rough bone trabeculation (HP:0100670)3.46227248
16Selective tooth agenesis (HP:0001592)3.38872179
17Patellar aplasia (HP:0006443)3.34996880
18Renal Fanconi syndrome (HP:0001994)3.33381772
19Colon cancer (HP:0003003)3.32068764
20Oral leukoplakia (HP:0002745)3.30129960
21Degeneration of anterior horn cells (HP:0002398)3.26501371
22Abnormality of the anterior horn cell (HP:0006802)3.26501371
23Abnormal number of erythroid precursors (HP:0012131)3.26344345
24Hepatocellular necrosis (HP:0001404)3.24728517
25Aplastic anemia (HP:0001915)3.24637813
26Aplasia/Hypoplasia of the patella (HP:0006498)3.21811716
27Cerebral edema (HP:0002181)3.17396389
28Increased serum lactate (HP:0002151)3.04921520
29Hepatic necrosis (HP:0002605)2.99376055
30Agnosia (HP:0010524)2.97470673
31Chromsome breakage (HP:0040012)2.93109634
323-Methylglutaconic aciduria (HP:0003535)2.88308872
33Meckel diverticulum (HP:0002245)2.85887591
34Medulloblastoma (HP:0002885)2.78870573
35Abnormality of the ileum (HP:0001549)2.75986588
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75911219
37Macrocytic anemia (HP:0001972)2.72576779
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.71645173
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.71645173
40Ependymoma (HP:0002888)2.71252962
41Neoplasm of the pancreas (HP:0002894)2.67524913
42Abnormality of the preputium (HP:0100587)2.65721986
43Lactic acidosis (HP:0003128)2.65630689
44Abnormality of methionine metabolism (HP:0010901)2.65255040
45Volvulus (HP:0002580)2.63973001
46Increased serum pyruvate (HP:0003542)2.58539772
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.56639758
48Bone marrow hypocellularity (HP:0005528)2.56068826
49Premature graying of hair (HP:0002216)2.54913805
50Absent thumb (HP:0009777)2.54179428
51Abnormality of chromosome stability (HP:0003220)2.54067982
52Methylmalonic acidemia (HP:0002912)2.52793609
53Myelodysplasia (HP:0002863)2.52182803
54Impulsivity (HP:0100710)2.51183170
55Trismus (HP:0000211)2.50737848
56Microretrognathia (HP:0000308)2.50583612
57Pallor (HP:0000980)2.50368289
58Abnormality of the labia minora (HP:0012880)2.48697406
5911 pairs of ribs (HP:0000878)2.48466362
60Abnormal trabecular bone morphology (HP:0100671)2.47209184
61Multiple enchondromatosis (HP:0005701)2.45273488
62Absent radius (HP:0003974)2.44973488
63Glossoptosis (HP:0000162)2.41746355
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.41616990
65Thrombocytosis (HP:0001894)2.41412852
66Muscle fiber atrophy (HP:0100295)2.35262006
67Irregular epiphyses (HP:0010582)2.34824395
68Microvesicular hepatic steatosis (HP:0001414)2.31961545
69Optic disc pallor (HP:0000543)2.30747051
70Increased intramyocellular lipid droplets (HP:0012240)2.30672307
71Abnormal lung lobation (HP:0002101)2.30072646
72Stenosis of the external auditory canal (HP:0000402)2.27613936
73Type 2 muscle fiber atrophy (HP:0003554)2.27141993
74Abnormality of glycolysis (HP:0004366)2.26702606
75Congenital, generalized hypertrichosis (HP:0004540)2.25169761
76Amaurosis fugax (HP:0100576)2.24379909
77Progressive muscle weakness (HP:0003323)2.24329478
78Absent forearm bone (HP:0003953)2.24120936
79Aplasia involving forearm bones (HP:0009822)2.24120936
80Abnormality of the umbilical cord (HP:0010881)2.23022628
81Small intestinal stenosis (HP:0012848)2.21349063
82Duodenal stenosis (HP:0100867)2.21349063
83Abnormal protein glycosylation (HP:0012346)2.21134214
84Abnormal glycosylation (HP:0012345)2.21134214
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21134214
86Abnormal protein N-linked glycosylation (HP:0012347)2.21134214
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19017426
88Premature ovarian failure (HP:0008209)2.17685428
89Secondary amenorrhea (HP:0000869)2.17206256
90Exertional dyspnea (HP:0002875)2.15744589
91Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15391764
92Supernumerary spleens (HP:0009799)2.15092213
93Basal cell carcinoma (HP:0002671)2.13736533
94Exercise intolerance (HP:0003546)2.13436025
95Respiratory failure (HP:0002878)2.13052742
96Leukodystrophy (HP:0002415)2.12182573
97Sloping forehead (HP:0000340)2.11838065
98Cellular immunodeficiency (HP:0005374)2.10952121
99Atresia of the external auditory canal (HP:0000413)2.10459329
100Megaloblastic anemia (HP:0001889)2.09270681
101Horseshoe kidney (HP:0000085)2.08782793
102Bifid tongue (HP:0010297)2.08278615
103CNS hypomyelination (HP:0003429)2.06912099
104Abnormal number of incisors (HP:0011064)2.06359580
105Methylmalonic aciduria (HP:0012120)2.05629731
106Abnormality of serum amino acid levels (HP:0003112)2.05493467
107Proximal placement of thumb (HP:0009623)2.03287219
108Tracheoesophageal fistula (HP:0002575)2.02691420
109Abnormality of midbrain morphology (HP:0002418)2.01110965
110Molar tooth sign on MRI (HP:0002419)2.01110965
111Lethargy (HP:0001254)2.01038734
112Rhabdomyosarcoma (HP:0002859)2.00981837
113Lymphoma (HP:0002665)1.99921579
114Abnormality of renal resorption (HP:0011038)1.99108146
115Slender long bone (HP:0003100)1.98749015
116Pelvic girdle muscle weakness (HP:0003749)1.98187948
117Aplasia/hypoplasia of the humerus (HP:0006507)1.97227512
118Pancreatic cysts (HP:0001737)1.97091728
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96824773
120Deviation of the thumb (HP:0009603)1.95995219
121Pancytopenia (HP:0001876)1.95137704
122Abnormal spermatogenesis (HP:0008669)1.94508518
123Hyperglycinemia (HP:0002154)1.94198677
124Median cleft lip (HP:0000161)1.93475229
125Hypoplasia of the fovea (HP:0007750)1.92930003
126Aplasia/Hypoplasia of the fovea (HP:0008060)1.92930003
127Atrophy/Degeneration involving motor neurons (HP:0007373)1.92250085
128Entropion (HP:0000621)1.92110612
129Cleft eyelid (HP:0000625)1.91942622
130Respiratory difficulties (HP:0002880)1.91537297
131Abnormality of the calcaneus (HP:0008364)1.91263942
132Reduced antithrombin III activity (HP:0001976)1.90694057
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90522277
134Poor head control (HP:0002421)1.90461792
135Medial flaring of the eyebrow (HP:0010747)1.88571865
136Generalized aminoaciduria (HP:0002909)1.88187636
137Retinal dysplasia (HP:0007973)1.88103899
138Hypoplasia of the pons (HP:0012110)1.87419133
139Abnormality of the pons (HP:0007361)1.87195256
140Sparse eyelashes (HP:0000653)1.87104741
141Squamous cell carcinoma (HP:0002860)1.84574182
142Abnormality of the duodenum (HP:0002246)1.82502892
143Triphalangeal thumb (HP:0001199)1.81433337
144Pancreatic fibrosis (HP:0100732)1.81321814
145Ureteral duplication (HP:0000073)1.81302816
146Abnormality of alanine metabolism (HP:0010916)1.79896684
147Hyperalaninemia (HP:0003348)1.79896684
148Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79896684
149Abnormality of the fovea (HP:0000493)1.79506322
150Missing ribs (HP:0000921)1.77782242
151Facial hemangioma (HP:0000329)1.76844042
152Neoplasm of the colon (HP:0100273)1.76043440
153Type I transferrin isoform profile (HP:0003642)1.74798125
154True hermaphroditism (HP:0010459)1.74650755
155Aseptic necrosis (HP:0010885)1.73907659
156Personality changes (HP:0000751)1.73456326
157CNS demyelination (HP:0007305)1.73162048
158X-linked dominant inheritance (HP:0001423)1.72614767
159Testicular atrophy (HP:0000029)1.72327297
160Postnatal microcephaly (HP:0005484)1.72114681
161Short thumb (HP:0009778)1.70299904
162Facial cleft (HP:0002006)1.69802860
163Septo-optic dysplasia (HP:0100842)1.69544006
164Glioma (HP:0009733)1.69415591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.28969092
2WEE14.48169999
3EIF2AK13.72620493
4CDC73.47833421
5TSSK62.92231103
6VRK22.82476847
7ACVR1B2.78373050
8SRPK12.62599654
9EIF2AK32.61377237
10NEK22.50179171
11PLK42.45818096
12NME22.36766818
13NEK12.19856767
14BRSK22.18919299
15STK162.03687231
16WNK32.02918908
17BMPR1B1.99200706
18TRIM281.96549316
19PLK11.95721595
20MKNK11.89014141
21PLK31.80215108
22TTK1.77334988
23NUAK11.74681447
24TESK21.72157008
25PASK1.70185305
26TGFBR11.64146428
27RPS6KB21.57977279
28TLK11.57381450
29CDK71.53491446
30AURKB1.51302098
31EPHA21.48411339
32VRK11.45606802
33ATR1.43969228
34MKNK21.41847827
35DYRK31.38519046
36BRSK11.36054100
37TNIK1.33305358
38RPS6KA41.31257080
39CHEK21.30111162
40AURKA1.25159758
41TAF11.24278995
42MAP3K121.20865754
43ZAK1.20321275
44CDK41.14749787
45ERBB31.11366578
46CSNK1G11.09712328
47BCR1.08888073
48MAP3K81.08156398
49CHEK11.06865694
50PIM21.04998307
51TESK11.03057491
52MAP4K21.02051073
53CASK1.00852990
54EIF2AK20.96787535
55SCYL20.92962606
56STK100.91965779
57CCNB10.91053622
58CSNK1G30.89752299
59PLK20.88869395
60PAK40.88298877
61EEF2K0.87684305
62MAP3K40.85560757
63INSRR0.85066401
64MAP2K70.83164890
65STK38L0.82634711
66PIM10.77127878
67IRAK30.76561897
68CSNK1G20.75289789
69CDK20.71795285
70LIMK10.70928118
71MAP3K100.70752797
72CSNK2A20.70445270
73ERBB40.70374795
74FLT30.69722285
75CDK80.68845660
76CDK120.65958879
77CSNK2A10.65597965
78CDK30.65162282
79ALK0.65013699
80GRK10.64317590
81ATM0.64314645
82STK40.63782954
83CDK190.63103087
84TAOK20.62618878
85MAP2K30.61153470
86PAK10.60741264
87MAP4K10.60175691
88CLK10.59406027
89PBK0.58910305
90PDK40.56876390
91PDK30.56876390
92MELK0.56814650
93CSNK1A1L0.54997931
94KDR0.54686470
95ADRBK20.53311591
96DYRK20.52750943
97PRKCI0.52558894
98TEC0.52238790
99DAPK10.52185367
100CDK10.51406872
101IRAK40.50777942
102CSNK1E0.49492890
103OXSR10.48557688
104AKT30.48153393
105BRAF0.46253692
106BCKDK0.46246854
107MST40.44783338
108BRD40.43327318
109MAPK130.43154512
110MAP3K30.42830226
111LRRK20.42303838
112JAK30.40643973
113MAP3K110.40281587
114ZAP700.39279380
115MAPKAPK30.37850701
116PRKCG0.37599637
117TIE10.37178183
118NME10.36083750
119CDK90.35758835
120ILK0.35018009
121MET0.34638233
122PHKG20.33416735
123PHKG10.33416735
124STK30.32846628
125MINK10.31543100
126CDK60.31497837
127TXK0.31301839
128PDK20.30775713
129PNCK0.30769513
130IKBKB0.30300218
131RPS6KA50.30128820
132KIT0.29694405
133ABL20.28719121
134BLK0.27391748
135CSF1R0.26039150
136BTK0.25982463
137FGFR10.25605893
138MTOR0.25128148

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.49617936
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.07880807
3Mismatch repair_Homo sapiens_hsa034303.82585103
4Proteasome_Homo sapiens_hsa030503.78989342
5RNA polymerase_Homo sapiens_hsa030203.51906658
6RNA transport_Homo sapiens_hsa030133.25469472
7Spliceosome_Homo sapiens_hsa030403.25109764
8Ribosome_Homo sapiens_hsa030103.23145939
9Oxidative phosphorylation_Homo sapiens_hsa001903.09828315
10Parkinsons disease_Homo sapiens_hsa050122.79795833
11Base excision repair_Homo sapiens_hsa034102.76920075
12Nucleotide excision repair_Homo sapiens_hsa034202.68578677
13Homologous recombination_Homo sapiens_hsa034402.67388221
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.62432902
15Cell cycle_Homo sapiens_hsa041102.58393306
16One carbon pool by folate_Homo sapiens_hsa006702.55235607
17Pyrimidine metabolism_Homo sapiens_hsa002402.47703630
18Basal transcription factors_Homo sapiens_hsa030221.93451931
19Fanconi anemia pathway_Homo sapiens_hsa034601.90841991
20Alzheimers disease_Homo sapiens_hsa050101.75369976
21RNA degradation_Homo sapiens_hsa030181.72241896
22Non-homologous end-joining_Homo sapiens_hsa034501.71619434
23p53 signaling pathway_Homo sapiens_hsa041151.60601418
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57963479
25mRNA surveillance pathway_Homo sapiens_hsa030151.54763392
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48713418
27Purine metabolism_Homo sapiens_hsa002301.37183045
28Epstein-Barr virus infection_Homo sapiens_hsa051691.35767730
29Vitamin B6 metabolism_Homo sapiens_hsa007501.33828444
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32964813
31Propanoate metabolism_Homo sapiens_hsa006401.19195384
32Steroid biosynthesis_Homo sapiens_hsa001001.17764621
33Pyruvate metabolism_Homo sapiens_hsa006201.17150845
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09052906
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08700389
36Folate biosynthesis_Homo sapiens_hsa007901.04585068
37Fatty acid elongation_Homo sapiens_hsa000621.03986807
38Herpes simplex infection_Homo sapiens_hsa051681.01895505
39Systemic lupus erythematosus_Homo sapiens_hsa053221.00545072
40Antigen processing and presentation_Homo sapiens_hsa046120.99577884
41Legionellosis_Homo sapiens_hsa051340.99313241
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95737688
43Cardiac muscle contraction_Homo sapiens_hsa042600.94486933
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.93943577
45Pentose phosphate pathway_Homo sapiens_hsa000300.93587451
46Protein export_Homo sapiens_hsa030600.92619610
47Biosynthesis of amino acids_Homo sapiens_hsa012300.90899002
48Viral carcinogenesis_Homo sapiens_hsa052030.89764500
49Selenocompound metabolism_Homo sapiens_hsa004500.84951255
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81617291
51Sulfur relay system_Homo sapiens_hsa041220.79911785
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78755757
53Oocyte meiosis_Homo sapiens_hsa041140.77299157
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71462561
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.70333255
56Butanoate metabolism_Homo sapiens_hsa006500.68094428
57Thyroid cancer_Homo sapiens_hsa052160.66416563
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64513119
59HTLV-I infection_Homo sapiens_hsa051660.62632892
60Sulfur metabolism_Homo sapiens_hsa009200.62084556
61Phototransduction_Homo sapiens_hsa047440.60808519
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.58088541
63Measles_Homo sapiens_hsa051620.56056455
64Peroxisome_Homo sapiens_hsa041460.54561420
65Caffeine metabolism_Homo sapiens_hsa002320.52016414
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51843895
67Apoptosis_Homo sapiens_hsa042100.50753565
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50522499
69Allograft rejection_Homo sapiens_hsa053300.49809621
70Small cell lung cancer_Homo sapiens_hsa052220.48998174
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47808713
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47097438
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46762885
74Graft-versus-host disease_Homo sapiens_hsa053320.45847407
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.45743387
76Glutathione metabolism_Homo sapiens_hsa004800.45659836
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45658593
78Carbon metabolism_Homo sapiens_hsa012000.44751518
79Shigellosis_Homo sapiens_hsa051310.43131301
80MicroRNAs in cancer_Homo sapiens_hsa052060.42444602
81Fructose and mannose metabolism_Homo sapiens_hsa000510.41771788
82Regulation of autophagy_Homo sapiens_hsa041400.41765269
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41386448
84Type I diabetes mellitus_Homo sapiens_hsa049400.41219218
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39877761
86N-Glycan biosynthesis_Homo sapiens_hsa005100.38236959
87Primary immunodeficiency_Homo sapiens_hsa053400.36738304
88Collecting duct acid secretion_Homo sapiens_hsa049660.36473128
89Asthma_Homo sapiens_hsa053100.35337185
90Hematopoietic cell lineage_Homo sapiens_hsa046400.35080179
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34694384
92Leishmaniasis_Homo sapiens_hsa051400.34620224
93Hepatitis B_Homo sapiens_hsa051610.33993094
94Influenza A_Homo sapiens_hsa051640.33190450
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32392297
96TGF-beta signaling pathway_Homo sapiens_hsa043500.31861601
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30879109
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29581707
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29554744
100Renin-angiotensin system_Homo sapiens_hsa046140.28871513
101Olfactory transduction_Homo sapiens_hsa047400.28785150
102Colorectal cancer_Homo sapiens_hsa052100.26630103
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25185690
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24633288
105Chemical carcinogenesis_Homo sapiens_hsa052040.24610388
106Fatty acid metabolism_Homo sapiens_hsa012120.24394855
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24106959
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24098855
109Huntingtons disease_Homo sapiens_hsa050160.23992609
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.23415424
111Acute myeloid leukemia_Homo sapiens_hsa052210.22703515
112Viral myocarditis_Homo sapiens_hsa054160.22579311
113Hedgehog signaling pathway_Homo sapiens_hsa043400.21849913
114Alcoholism_Homo sapiens_hsa050340.21343297
115Bladder cancer_Homo sapiens_hsa052190.20953754
116Hippo signaling pathway_Homo sapiens_hsa043900.20447975
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20304439
118HIF-1 signaling pathway_Homo sapiens_hsa040660.20061288
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19087920
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18567874
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18398690
122Metabolic pathways_Homo sapiens_hsa011000.18289384
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17421185
124Taste transduction_Homo sapiens_hsa047420.17002698
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16341719
126Chronic myeloid leukemia_Homo sapiens_hsa052200.16129194
127Basal cell carcinoma_Homo sapiens_hsa052170.15753164
128Wnt signaling pathway_Homo sapiens_hsa043100.15724880
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15484020
130Tryptophan metabolism_Homo sapiens_hsa003800.15399743
131Galactose metabolism_Homo sapiens_hsa000520.15378333
132Retinol metabolism_Homo sapiens_hsa008300.14478832
133Arginine and proline metabolism_Homo sapiens_hsa003300.14420484
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.14065836
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13837615
136Notch signaling pathway_Homo sapiens_hsa043300.13744558
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13323566
138Pathways in cancer_Homo sapiens_hsa052000.13087668
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13054378
140Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.11522227
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.10730714
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07419642

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