PWWP2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of telomerase activity (GO:0051974)6.27269135
2telomere maintenance via telomerase (GO:0007004)6.21289543
3regulation of helicase activity (GO:0051095)6.14392705
4negative regulation of telomere maintenance (GO:0032205)5.46696174
5mitotic sister chromatid cohesion (GO:0007064)4.95215461
6DNA damage induced protein phosphorylation (GO:0006975)4.75267922
7nuclear pore organization (GO:0006999)4.48702196
8RNA-dependent DNA replication (GO:0006278)4.40298526
9regulation of DNA endoreduplication (GO:0032875)4.39881573
10interkinetic nuclear migration (GO:0022027)4.37486774
11nuclear pore complex assembly (GO:0051292)4.32728295
12ventricular trabecula myocardium morphogenesis (GO:0003222)4.31318638
13DNA damage response, detection of DNA damage (GO:0042769)4.16032284
14regulation of telomerase activity (GO:0051972)4.13481809
15regulation of posttranscriptional gene silencing (GO:0060147)4.07451817
16regulation of gene silencing by miRNA (GO:0060964)4.07451817
17regulation of gene silencing by RNA (GO:0060966)4.07451817
18histone H3-K4 trimethylation (GO:0080182)4.04976759
19regulation of meiosis I (GO:0060631)3.88262407
20negative regulation of DNA biosynthetic process (GO:2000279)3.82027472
21kinetochore organization (GO:0051383)3.78375799
22DNA topological change (GO:0006265)3.71692134
23negative regulation of histone methylation (GO:0031061)3.71388728
24single strand break repair (GO:0000012)3.70236653
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.63751374
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.63711379
27negative regulation of translation, ncRNA-mediated (GO:0040033)3.60278485
28regulation of translation, ncRNA-mediated (GO:0045974)3.60278485
29negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.60278485
30DNA unwinding involved in DNA replication (GO:0006268)3.54056536
31regulation of RNA export from nucleus (GO:0046831)3.51562537
32mRNA splice site selection (GO:0006376)3.48484324
33pore complex assembly (GO:0046931)3.42620673
34mitotic metaphase plate congression (GO:0007080)3.42518912
35kinetochore assembly (GO:0051382)3.42306034
36pre-miRNA processing (GO:0031054)3.41760171
37heart trabecula morphogenesis (GO:0061384)3.40932716
38regulation of nuclear cell cycle DNA replication (GO:0033262)3.40033810
39histone H3-K4 methylation (GO:0051568)3.37043836
40peptidyl-lysine trimethylation (GO:0018023)3.33452199
41DNA replication checkpoint (GO:0000076)3.30089801
42DNA replication-independent nucleosome assembly (GO:0006336)3.28212596
43DNA replication-independent nucleosome organization (GO:0034724)3.28212596
44metaphase plate congression (GO:0051310)3.21820973
45cardiac right ventricle morphogenesis (GO:0003215)3.21600442
46regulation of sister chromatid cohesion (GO:0007063)3.21086688
47negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.20429897
48protein K6-linked ubiquitination (GO:0085020)3.20141005
49CENP-A containing nucleosome assembly (GO:0034080)3.18891754
50DNA geometric change (GO:0032392)3.17510713
51gastrulation with mouth forming second (GO:0001702)3.17237360
52DNA duplex unwinding (GO:0032508)3.16634718
53regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16231355
54regulation of mitotic spindle checkpoint (GO:1903504)3.16231355
55maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.14309373
56replication fork processing (GO:0031297)3.13607594
57regulation of histone H3-K27 methylation (GO:0061085)3.13289152
58artery development (GO:0060840)3.13184777
59chromatin remodeling at centromere (GO:0031055)3.12053280
60histone H2A acetylation (GO:0043968)3.10771315
61DNA replication initiation (GO:0006270)3.09247406
62activin receptor signaling pathway (GO:0032924)3.08505118
63presynaptic membrane assembly (GO:0097105)3.07432922
64regulation of stem cell maintenance (GO:2000036)3.07313062
65protein localization to kinetochore (GO:0034501)3.06345850
66kidney morphogenesis (GO:0060993)3.05007038
67mitotic chromosome condensation (GO:0007076)3.04030184
68sister chromatid cohesion (GO:0007062)3.02018045
69positive regulation of histone H3-K4 methylation (GO:0051571)3.01232651
70regulation of histone H3-K9 methylation (GO:0051570)3.01008424
71nucleus localization (GO:0051647)3.00714829
72attachment of spindle microtubules to kinetochore (GO:0008608)2.99287711
73mitotic nuclear envelope disassembly (GO:0007077)2.98794653
74neural tube formation (GO:0001841)2.97771436
75sister chromatid segregation (GO:0000819)2.96482817
76protein localization to chromosome, centromeric region (GO:0071459)2.96157099
77nodal signaling pathway (GO:0038092)2.95514712
78spermatid nucleus differentiation (GO:0007289)2.91716127
79histone H3-K9 methylation (GO:0051567)2.90528027
80nucleobase biosynthetic process (GO:0046112)2.90015052
81somatic hypermutation of immunoglobulin genes (GO:0016446)2.88331128
82somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88331128
83negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.86981518
84chromatin assembly or disassembly (GO:0006333)2.83267630
85presynaptic membrane organization (GO:0097090)2.83013861
86monoubiquitinated protein deubiquitination (GO:0035520)2.82995181
87regulation of gene expression by genetic imprinting (GO:0006349)2.82827020
88regulation of histone methylation (GO:0031060)2.82818603
89microtubule anchoring (GO:0034453)2.82768687
90purine nucleobase biosynthetic process (GO:0009113)2.82738692
91snRNA transcription (GO:0009301)2.80966971
92negative regulation of RNA splicing (GO:0033119)2.79748019
93meiotic chromosome segregation (GO:0045132)2.79471070
94regulation of chromatin silencing (GO:0031935)2.78664648
95DNA double-strand break processing (GO:0000729)2.77466001
96regulation of DNA-dependent DNA replication (GO:0090329)2.77284084
97histone lysine methylation (GO:0034968)2.76689173
98regulation of gene silencing (GO:0060968)2.75411055
99membrane disassembly (GO:0030397)2.75302361
100nuclear envelope disassembly (GO:0051081)2.75302361
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.75177272
102establishment of chromosome localization (GO:0051303)2.74432527
103resolution of meiotic recombination intermediates (GO:0000712)2.74065335
104regulation of centriole replication (GO:0046599)2.72423277
105otic vesicle formation (GO:0030916)2.71339268
106mitotic sister chromatid segregation (GO:0000070)2.71261108
107ATP-dependent chromatin remodeling (GO:0043044)2.70988769
108atrial cardiac muscle cell action potential (GO:0086014)2.70348726
109histone exchange (GO:0043486)2.70140730
110mismatch repair (GO:0006298)2.70001543
111regulation of telomere maintenance (GO:0032204)2.69922762
112DNA conformation change (GO:0071103)2.69179180
113regulation of hippo signaling (GO:0035330)2.67177440
114regulation of nucleobase-containing compound transport (GO:0032239)2.65864740
115negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.65561184
116intra-S DNA damage checkpoint (GO:0031573)2.65347287
117regulation of histone H3-K4 methylation (GO:0051569)2.65278925
118photoreceptor cell maintenance (GO:0045494)2.62964683
119regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.62672154
120protein localization to chromosome (GO:0034502)2.62344742
121positive regulation of DNA-dependent DNA replication (GO:2000105)2.61945808
122negative regulation of DNA replication (GO:0008156)2.60894339
123positive regulation of histone methylation (GO:0031062)2.60324132
124positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.60122819
125brain morphogenesis (GO:0048854)2.59967659
126establishment of nucleus localization (GO:0040023)2.58839186
127histone H3-K9 modification (GO:0061647)2.58728389
128mitotic G2/M transition checkpoint (GO:0044818)2.56406914
129definitive hemopoiesis (GO:0060216)2.56369872
130DNA strand renaturation (GO:0000733)2.55793385
131histone H4-K12 acetylation (GO:0043983)2.53497899
132regulation of telomere maintenance via telomerase (GO:0032210)2.53373775
133spindle checkpoint (GO:0031577)2.52974779
134prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.52904166
135histone methylation (GO:0016571)2.52793980
136chromatin assembly (GO:0031497)2.52434072
137organ growth (GO:0035265)2.52274180
138negative regulation of DNA recombination (GO:0045910)2.51978913
139glycerophospholipid catabolic process (GO:0046475)2.51685792
140protein K63-linked deubiquitination (GO:0070536)2.50678878
141pancreas development (GO:0031016)2.50508751
142Sertoli cell development (GO:0060009)2.49833831
143positive regulation of gene expression, epigenetic (GO:0045815)2.49766572
144histone H2A monoubiquitination (GO:0035518)2.49456796
145regulation of centrosome cycle (GO:0046605)2.49228640
146negative regulation of mRNA processing (GO:0050686)2.49002380
147cytoplasmic mRNA processing body assembly (GO:0033962)2.48553747
148positive regulation of cellular response to oxidative stress (GO:1900409)2.47829557
149positive regulation of response to oxidative stress (GO:1902884)2.47829557
150keratinocyte development (GO:0003334)2.47585289
151positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.46607292
152positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.46607292
153positive regulation of mitotic sister chromatid separation (GO:1901970)2.46607292
154mRNA transport (GO:0051028)2.46028455
155spindle assembly checkpoint (GO:0071173)2.45192386
156double-strand break repair via homologous recombination (GO:0000724)2.44712413
157histone mRNA catabolic process (GO:0071044)2.44313501
158RNA splicing, via transesterification reactions (GO:0000375)2.44292056
159recombinational repair (GO:0000725)2.42393081
160inner ear receptor cell development (GO:0060119)2.42052841
161detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.41905736
162positive regulation of SMAD protein import into nucleus (GO:0060391)2.41862787
163ncRNA catabolic process (GO:0034661)2.40572710
164synapsis (GO:0007129)2.40152599
165establishment of protein localization to Golgi (GO:0072600)2.40055370
166negative regulation of transcription regulatory region DNA binding (GO:2000678)2.39826676
167protein neddylation (GO:0045116)2.37983395
168histone H2A ubiquitination (GO:0033522)2.34295473
169retina development in camera-type eye (GO:0060041)2.33334526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.27594341
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.30614550
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.12445238
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.95254060
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.40123127
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.38705584
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83176639
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.72167861
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.70946570
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.52490982
11CIITA_25753668_ChIP-Seq_RAJI_Human2.39300082
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.39267671
13YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37235914
14TAF15_26573619_Chip-Seq_HEK293_Human2.29013879
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23996357
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.22425045
17ZNF274_21170338_ChIP-Seq_K562_Hela2.13343231
18FUS_26573619_Chip-Seq_HEK293_Human2.05697450
19EWS_26573619_Chip-Seq_HEK293_Human2.03025314
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.98824436
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91533127
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.88179264
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.83546543
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81904166
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.76887040
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75710271
27IGF1R_20145208_ChIP-Seq_DFB_Human1.75622884
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72082400
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.72042649
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70705267
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70378713
32ER_23166858_ChIP-Seq_MCF-7_Human1.69419062
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65514327
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65122836
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63690146
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60710128
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58438987
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58180249
39SMAD4_21799915_ChIP-Seq_A2780_Human1.57628439
40STAT3_23295773_ChIP-Seq_U87_Human1.57433509
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55685759
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54193156
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53942942
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53842529
45CBP_20019798_ChIP-Seq_JUKART_Human1.52397613
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52397613
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.52030018
48MYC_22102868_ChIP-Seq_BL_Human1.51831592
49AR_21909140_ChIP-Seq_LNCAP_Human1.49937872
50ELK1_19687146_ChIP-ChIP_HELA_Human1.48782015
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47459843
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46926574
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43692033
54VDR_23849224_ChIP-Seq_CD4+_Human1.43342735
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43307368
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42099244
57* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40230936
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39956879
59VDR_22108803_ChIP-Seq_LS180_Human1.39754096
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.38437516
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38372652
62TCF4_23295773_ChIP-Seq_U87_Human1.36802086
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34591451
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32641858
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.32240235
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31753605
67MYC_18940864_ChIP-ChIP_HL60_Human1.30653659
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30618765
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.30025340
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29309438
71* FOXP3_21729870_ChIP-Seq_TREG_Human1.28142011
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27461977
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24397510
74BCAT_22108803_ChIP-Seq_LS180_Human1.24195972
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.23837647
76TCF4_22108803_ChIP-Seq_LS180_Human1.23372327
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21642880
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20764072
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18907620
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18475791
81P53_22387025_ChIP-Seq_ESCs_Mouse1.18296629
82STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18210531
83RUNX2_22187159_ChIP-Seq_PCA_Human1.17303404
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17060110
85* FLI1_21867929_ChIP-Seq_TH2_Mouse1.16492009
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15442902
87KDM5A_27292631_Chip-Seq_BREAST_Human1.15015992
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14598603
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.13906811
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13184867
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12620953
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.12463528
93* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12260852
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12016408
95* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10953157
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10707088
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10449623
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10052812
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09122634
100THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08516661
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08302743
102SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07980052
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07356607
104TTF2_22483619_ChIP-Seq_HELA_Human1.06718594
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06335124
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05567552
107SCL_19346495_ChIP-Seq_HPC-7_Human1.05043642
108P300_18555785_Chip-Seq_ESCs_Mouse1.04925923
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04508532
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.04034067
111SALL4_22934838_ChIP-ChIP_CD34+_Human1.03102990
112GBX2_23144817_ChIP-Seq_PC3_Human1.01942060
113HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01760406
114* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01491919
115TP53_22573176_ChIP-Seq_HFKS_Human1.01247321
116SOX2_16153702_ChIP-ChIP_HESCs_Human1.01228563
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00174435
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99194114
119AR_25329375_ChIP-Seq_VCAP_Human0.98591068
120* CDX2_22108803_ChIP-Seq_LS180_Human0.98217616
121RNF2_27304074_Chip-Seq_NSC_Mouse0.97793285
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97695340
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97519887
124MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97236110
125ETS1_20019798_ChIP-Seq_JURKAT_Human0.96561146
126POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96074221
127FLI1_27457419_Chip-Seq_LIVER_Mouse0.95798186
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95769743
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95652474
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95652474
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94894925
132* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92103063
133TP53_16413492_ChIP-PET_HCT116_Human0.91183769
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90658959
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89901685
136NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89828946
137XRN2_22483619_ChIP-Seq_HELA_Human0.89498435
138TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87587340
139POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86019080
140RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85683175
141IRF1_19129219_ChIP-ChIP_H3396_Human0.85447012
142NANOG_16153702_ChIP-ChIP_HESCs_Human0.85439540
143EZH2_22144423_ChIP-Seq_EOC_Human0.84339905
144TBX3_20139965_ChIP-Seq_ESCs_Mouse0.83880227
145NANOG_21062744_ChIP-ChIP_HESCs_Human0.83611964
146TCF4_18268006_ChIP-ChIP_LS174T_Human0.83494826
147CREB1_15753290_ChIP-ChIP_HEK293T_Human0.83273594
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83077849
149TBX3_20139965_ChIP-Seq_MESCs_Mouse0.82223053
150PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82051921
151* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79668053
152SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79360489
153ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78825803
154* P300_19829295_ChIP-Seq_ESCs_Human0.78295420
155SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.78096737
156* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76611664
157* SOX9_26525672_Chip-Seq_HEART_Mouse0.76237302
158DCP1A_22483619_ChIP-Seq_HELA_Human0.76184862
159ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.73885196
160GABP_17652178_ChIP-ChIP_JURKAT_Human0.73650247

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.20366415
2MP0008057_abnormal_DNA_replication3.89818584
3MP0010094_abnormal_chromosome_stability3.52306635
4MP0003121_genomic_imprinting3.17664312
5MP0003077_abnormal_cell_cycle3.09025091
6MP0003111_abnormal_nucleus_morphology3.03723868
7MP0006292_abnormal_olfactory_placode3.02145425
8MP0003693_abnormal_embryo_hatching2.93186526
9MP0008877_abnormal_DNA_methylation2.85367054
10MP0000569_abnormal_digit_pigmentation2.67876588
11MP0003880_abnormal_central_pattern2.67695779
12MP0002396_abnormal_hematopoietic_system2.57009107
13MP0008058_abnormal_DNA_repair2.55388842
14MP0003567_abnormal_fetal_cardiomyocyte2.54020005
15MP0004957_abnormal_blastocyst_morpholog2.45469968
16MP0003890_abnormal_embryonic-extraembry2.36200078
17MP0008007_abnormal_cellular_replicative2.36190171
18MP0005084_abnormal_gallbladder_morpholo2.24584004
19MP0003123_paternal_imprinting2.22147265
20MP0002653_abnormal_ependyma_morphology2.05904419
21MP0006276_abnormal_autonomic_nervous1.95856464
22MP0000350_abnormal_cell_proliferation1.85824147
23MP0005379_endocrine/exocrine_gland_phen1.83541200
24MP0002254_reproductive_system_inflammat1.82014556
25MP0002009_preneoplasia1.77017575
26MP0003122_maternal_imprinting1.75183262
27MP0002938_white_spotting1.73952792
28MP0004808_abnormal_hematopoietic_stem1.61876816
29MP0000631_abnormal_neuroendocrine_gland1.61637254
30MP0002751_abnormal_autonomic_nervous1.59073542
31MP0001188_hyperpigmentation1.57751396
32MP0005551_abnormal_eye_electrophysiolog1.57421002
33MP0001730_embryonic_growth_arrest1.56649733
34MP0005380_embryogenesis_phenotype1.54303683
35MP0001672_abnormal_embryogenesis/_devel1.54303683
36MP0003984_embryonic_growth_retardation1.52179812
37MP0002088_abnormal_embryonic_growth/wei1.50747421
38MP0008932_abnormal_embryonic_tissue1.45872371
39MP0002084_abnormal_developmental_patter1.45712018
40MP0004270_analgesia1.43087432
41MP0001529_abnormal_vocalization1.42320374
42MP0002085_abnormal_embryonic_tissue1.40578259
43MP0002086_abnormal_extraembryonic_tissu1.38540637
44MP0005174_abnormal_tail_pigmentation1.37896192
45MP0002233_abnormal_nose_morphology1.37089034
46MP0001697_abnormal_embryo_size1.36817220
47MP0000647_abnormal_sebaceous_gland1.36572631
48MP0001293_anophthalmia1.34179755
49MP0003943_abnormal_hepatobiliary_system1.30539458
50MP0004197_abnormal_fetal_growth/weight/1.28124184
51MP0003935_abnormal_craniofacial_develop1.25220344
52MP0004264_abnormal_extraembryonic_tissu1.25043691
53MP0001177_atelectasis1.24929925
54MP0000566_synostosis1.24140066
55MP0009672_abnormal_birth_weight1.23683285
56MP0003937_abnormal_limbs/digits/tail_de1.23317427
57MP0000015_abnormal_ear_pigmentation1.22151181
58MP0003718_maternal_effect1.22038249
59MP0004885_abnormal_endolymph1.19812789
60MP0009703_decreased_birth_body1.17897373
61MP0000383_abnormal_hair_follicle1.16937255
62MP0005253_abnormal_eye_physiology1.16616760
63MP0002736_abnormal_nociception_after1.16416016
64MP0005646_abnormal_pituitary_gland1.14542027
65MP0010030_abnormal_orbit_morphology1.13839973
66MP0005645_abnormal_hypothalamus_physiol1.10806770
67MP0009697_abnormal_copulation1.10264691
68MP0002080_prenatal_lethality1.06568755
69MP0000313_abnormal_cell_death1.03450256
70MP0001286_abnormal_eye_development1.03303023
71MP0000516_abnormal_urinary_system1.03228010
72MP0005367_renal/urinary_system_phenotyp1.03228010
73MP0002925_abnormal_cardiovascular_devel1.02662133
74MP0003861_abnormal_nervous_system1.02110801
75MP0000049_abnormal_middle_ear1.01943068
76MP0000432_abnormal_head_morphology1.00913366
77MP0010352_gastrointestinal_tract_polyps1.00275517
78MP0000703_abnormal_thymus_morphology1.00098732
79MP0000427_abnormal_hair_cycle0.99534640
80MP0004147_increased_porphyrin_level0.99034367
81MP0003941_abnormal_skin_development0.98044135
82MP0010368_abnormal_lymphatic_system0.97685448
83MP0003755_abnormal_palate_morphology0.97521717
84MP0005076_abnormal_cell_differentiation0.96219556
85MP0000490_abnormal_crypts_of0.93977979
86MP0005409_darkened_coat_color0.93041588
87MP0010678_abnormal_skin_adnexa0.91401428
88MP0004782_abnormal_surfactant_physiolog0.90254767
89MP0002095_abnormal_skin_pigmentation0.89943194
90MP0005171_absent_coat_pigmentation0.88462981
91MP0001879_abnormal_lymphatic_vessel0.87956063
92MP0008995_early_reproductive_senescence0.87595975
93MP0003136_yellow_coat_color0.87097767
94MP0002210_abnormal_sex_determination0.87046421
95MP0001919_abnormal_reproductive_system0.86530959
96MP0002075_abnormal_coat/hair_pigmentati0.86343175
97MP0002928_abnormal_bile_duct0.86037907
98MP0003828_pulmonary_edema0.85825150
99MP0003385_abnormal_body_wall0.84359879
100MP0010307_abnormal_tumor_latency0.83493933
101MP0002092_abnormal_eye_morphology0.83197102
102MP0003698_abnormal_male_reproductive0.82936112
103MP0004134_abnormal_chest_morphology0.80657402
104MP0005187_abnormal_penis_morphology0.80002630
105MP0003786_premature_aging0.79608211
106MP0005075_abnormal_melanosome_morpholog0.79121075
107MP0002398_abnormal_bone_marrow0.79106637
108MP0001485_abnormal_pinna_reflex0.77643379
109MP0003119_abnormal_digestive_system0.77433316
110MP0001968_abnormal_touch/_nociception0.77010794
111MP0002127_abnormal_cardiovascular_syste0.76477572
112MP0000778_abnormal_nervous_system0.76457978
113MP0005389_reproductive_system_phenotype0.76367802
114MP0005220_abnormal_exocrine_pancreas0.75546302
115MP0000428_abnormal_craniofacial_morphol0.75256026
116MP0005195_abnormal_posterior_eye0.75217311
117MP0001915_intracranial_hemorrhage0.75046432
118MP0001186_pigmentation_phenotype0.74779915
119MP0008775_abnormal_heart_ventricle0.74701916
120MP0001545_abnormal_hematopoietic_system0.74653977
121MP0005397_hematopoietic_system_phenotyp0.74653977
122MP0002734_abnormal_mechanical_nocicepti0.73686803
123MP0003115_abnormal_respiratory_system0.73580353
124MP0002116_abnormal_craniofacial_bone0.73510574
125MP0002111_abnormal_tail_morphology0.73075206
126MP0001984_abnormal_olfaction0.72646561
127MP0000266_abnormal_heart_morphology0.72388147
128MP0006072_abnormal_retinal_apoptosis0.71355926
129MP0001145_abnormal_male_reproductive0.71119160
130MP0004133_heterotaxia0.70542169
131MP0002177_abnormal_outer_ear0.70484241
132MP0002697_abnormal_eye_size0.69638426
133MP0003938_abnormal_ear_development0.69512338
134MP0002081_perinatal_lethality0.69020154
135MP0000653_abnormal_sex_gland0.68308351
136MP0005391_vision/eye_phenotype0.66193093
137MP0002102_abnormal_ear_morphology0.65433757
138MP0001929_abnormal_gametogenesis0.64745673
139MP0001119_abnormal_female_reproductive0.64367704
140MP0002163_abnormal_gland_morphology0.63127341
141MP0001784_abnormal_fluid_regulation0.62446572

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.64168463
2Birth length less than 3rd percentile (HP:0003561)3.79915374
3Esophageal atresia (HP:0002032)3.64681745
4Abnormality of the fingertips (HP:0001211)3.55838598
5Urethral obstruction (HP:0000796)3.20201550
6Chromsome breakage (HP:0040012)3.18674925
7Curly hair (HP:0002212)3.03672242
8Abnormality of the labia minora (HP:0012880)3.02902541
9Chromosomal breakage induced by crosslinking agents (HP:0003221)2.94659522
10Septo-optic dysplasia (HP:0100842)2.93612494
11Colon cancer (HP:0003003)2.91624408
12Abnormal hair whorl (HP:0010721)2.90771540
13Ectopic kidney (HP:0000086)2.86767637
14Medulloblastoma (HP:0002885)2.76710163
15Ependymoma (HP:0002888)2.76323742
16Long eyelashes (HP:0000527)2.70709316
17Intestinal fistula (HP:0100819)2.70147152
18Pancreatic islet-cell hyperplasia (HP:0004510)2.62826048
19Optic nerve hypoplasia (HP:0000609)2.62246413
20Abnormality of macular pigmentation (HP:0008002)2.61937194
21Stenosis of the external auditory canal (HP:0000402)2.58440809
22Abnormality of chromosome stability (HP:0003220)2.51029228
23Myelodysplasia (HP:0002863)2.45900873
24Patellar aplasia (HP:0006443)2.44920982
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43394590
26Agnosia (HP:0010524)2.42522028
27Intestinal atresia (HP:0011100)2.42189693
28Meckel diverticulum (HP:0002245)2.42137339
29Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.41505241
30Nephronophthisis (HP:0000090)2.41446155
31Thyroid carcinoma (HP:0002890)2.37446121
32Pancreatic fibrosis (HP:0100732)2.37365157
33Tubulointerstitial nephritis (HP:0001970)2.34413037
34Papillary thyroid carcinoma (HP:0002895)2.33336974
35Nephroblastoma (Wilms tumor) (HP:0002667)2.32343499
36Aqueductal stenosis (HP:0002410)2.30475672
37Hyperventilation (HP:0002883)2.30145230
38Abnormal rod and cone electroretinograms (HP:0008323)2.29845659
39Abnormality of the aortic arch (HP:0012303)2.29562907
40Abnormality of the ileum (HP:0001549)2.29295831
41Glioma (HP:0009733)2.27736138
42Pancreatic cysts (HP:0001737)2.27530250
43Supernumerary ribs (HP:0005815)2.27518042
44Aplastic anemia (HP:0001915)2.27443954
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.26951313
46Supernumerary bones of the axial skeleton (HP:0009144)2.26269735
47Rectovaginal fistula (HP:0000143)2.26042430
48Rectal fistula (HP:0100590)2.26042430
49Neoplasm of the adrenal cortex (HP:0100641)2.25961661
50Anal stenosis (HP:0002025)2.25404138
51Shawl scrotum (HP:0000049)2.23364414
52Truncal obesity (HP:0001956)2.22749574
53Abnormal biliary tract morphology (HP:0012440)2.19499721
54Hepatoblastoma (HP:0002884)2.19038974
55Aplasia/Hypoplasia of the patella (HP:0006498)2.19026758
56Stomach cancer (HP:0012126)2.18341802
57Biliary tract neoplasm (HP:0100574)2.18177520
58Abnormality of the incisor (HP:0000676)2.17451413
59Protruding tongue (HP:0010808)2.17079354
60Attenuation of retinal blood vessels (HP:0007843)2.16086715
61Abnormality of the preputium (HP:0100587)2.14646566
62Acute myeloid leukemia (HP:0004808)2.14526118
63Abnormal lung lobation (HP:0002101)2.14280914
64Hypoglycemic seizures (HP:0002173)2.14270729
65Abnormality of the astrocytes (HP:0100707)2.13407336
66Astrocytoma (HP:0009592)2.13407336
67Abnormality of the renal medulla (HP:0100957)2.12516916
68Rhabdomyosarcoma (HP:0002859)2.12120720
69Embryonal renal neoplasm (HP:0011794)2.12111717
70Genital tract atresia (HP:0001827)2.10251079
71Pendular nystagmus (HP:0012043)2.09891659
72Neoplasm of the oral cavity (HP:0100649)2.09399798
73Hip dysplasia (HP:0001385)2.07818563
74Clitoromegaly (HP:0000057)2.06854562
75Bifid tongue (HP:0010297)2.05919897
76Enlarged penis (HP:0000040)2.05570651
77Deep philtrum (HP:0002002)2.05512754
78Abnormal number of incisors (HP:0011064)2.05458541
79Acute lymphatic leukemia (HP:0006721)2.05325872
80Supernumerary spleens (HP:0009799)2.04707310
81Breast hypoplasia (HP:0003187)2.04259943
82Aplasia/Hypoplasia of the sternum (HP:0006714)2.02435842
83Prominent nose (HP:0000448)2.02364867
84Vaginal atresia (HP:0000148)2.00699456
85Duodenal stenosis (HP:0100867)2.00433794
86Small intestinal stenosis (HP:0012848)2.00433794
87Abnormality of the columella (HP:0009929)1.99962964
88Short 4th metacarpal (HP:0010044)1.99276590
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99276590
90Abnormality of endocrine pancreas physiology (HP:0012093)1.99231609
91Abnormality of the pancreatic islet cells (HP:0006476)1.99231609
92Deviation of the thumb (HP:0009603)1.98575640
93True hermaphroditism (HP:0010459)1.97983228
94Increased nuchal translucency (HP:0010880)1.96385878
95Facial hemangioma (HP:0000329)1.95412543
96Optic nerve coloboma (HP:0000588)1.95153993
97Proximal placement of thumb (HP:0009623)1.95079067
98Microtia (HP:0008551)1.94586827
99Medial flaring of the eyebrow (HP:0010747)1.94452010
100Renal cortical cysts (HP:0000803)1.93904702
101Abnormality of the phalanges of the 2nd finger (HP:0009541)1.93269368
102Short middle phalanx of finger (HP:0005819)1.92808572
103Impulsivity (HP:0100710)1.92255793
104Lip pit (HP:0100267)1.92034648
105Cystic hygroma (HP:0000476)1.90934900
106Abnormality of the septum pellucidum (HP:0007375)1.89392579
107Spinal muscular atrophy (HP:0007269)1.88567414
108Absent septum pellucidum (HP:0001331)1.86957783
109Cupped ear (HP:0000378)1.86617306
110Sloping forehead (HP:0000340)1.85195273
111Broad-based gait (HP:0002136)1.85190157
112Breast carcinoma (HP:0003002)1.84736500
113Atresia of the external auditory canal (HP:0000413)1.83514919
114Abnormality of the duodenum (HP:0002246)1.82923472
115Hypoplasia of the maxilla (HP:0000327)1.82464646
116High anterior hairline (HP:0009890)1.81544265
117Abolished electroretinogram (ERG) (HP:0000550)1.79455249
118Abnormality of the renal cortex (HP:0011035)1.79390644
119Gastrointestinal carcinoma (HP:0002672)1.78399008
120Malignant gastrointestinal tract tumors (HP:0006749)1.78399008
121Abnormality of chromosome segregation (HP:0002916)1.78162310
122Neoplasm of the small intestine (HP:0100833)1.77890299
123Hyperinsulinemic hypoglycemia (HP:0000825)1.77783400
124Broad thumb (HP:0011304)1.77138615
125Abnormality of the parietal bone (HP:0002696)1.76308036
126Diastasis recti (HP:0001540)1.75403143
127Neoplasm of striated muscle (HP:0009728)1.75066104
128Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74591992
129Cafe-au-lait spot (HP:0000957)1.74380569
130Low anterior hairline (HP:0000294)1.74122835
131Abnormality of the clitoris (HP:0000056)1.73008368
132Gaze-evoked nystagmus (HP:0000640)1.72572786
133Abnormality of the nasal septum (HP:0000419)1.72017969
134Gastrointestinal atresia (HP:0002589)1.70219510
135Growth hormone deficiency (HP:0000824)1.70059862
136Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.69746428
137Absent eyebrow (HP:0002223)1.69645658
138Febrile seizures (HP:0002373)1.68896339
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68814762
140Chronic hepatic failure (HP:0100626)1.67899184
141Abnormality of the carotid arteries (HP:0005344)1.67163836
142Broad palm (HP:0001169)1.67100463
143Aplasia/Hypoplasia of the hallux (HP:0008362)1.66472804
144Hypoplastic iliac wings (HP:0002866)1.66001057
145Vertebral arch anomaly (HP:0008438)1.65983510
146Bony spicule pigmentary retinopathy (HP:0007737)1.65425833
147Abnormality of incisor morphology (HP:0011063)1.64330406
148Lymphoma (HP:0002665)1.64235505
149Cutis marmorata (HP:0000965)1.63591437
150Short hallux (HP:0010109)1.63550462
151Midline defect of the nose (HP:0004122)1.63548398
152Cellular immunodeficiency (HP:0005374)1.63502850
153Molar tooth sign on MRI (HP:0002419)1.63219668
154Abnormality of midbrain morphology (HP:0002418)1.63219668
155Neonatal respiratory distress (HP:0002643)1.62841015
156Hypoplastic labia majora (HP:0000059)1.62785869
157Narrow palate (HP:0000189)1.62442496
158Gastroesophageal reflux (HP:0002020)1.61740943
159Smooth philtrum (HP:0000319)1.59800827
160Congenital primary aphakia (HP:0007707)1.59737289
161Depressed nasal tip (HP:0000437)1.59653181
162Trigonocephaly (HP:0000243)1.58257700
163Uterine neoplasm (HP:0010784)1.57417251
164Dynein arm defect of respiratory motile cilia (HP:0012255)1.56619247
165Absent/shortened dynein arms (HP:0200106)1.56619247

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.65222705
2MAP4K23.91160986
3CDK123.80289269
4FRK3.77586172
5INSRR3.25079702
6BRD43.06591367
7TNIK2.54373403
8MKNK22.53418971
9MKNK12.50927301
10WNK32.48536235
11SIK32.47288419
12SRPK12.40155783
13MAP3K62.35736765
14MAP2K62.26435219
15AKT32.11490404
16SIK22.10202513
17VRK12.00483829
18TTK1.97377943
19NEK21.89210826
20FGFR21.86951887
21ZAK1.84304856
22ACVR1B1.79712758
23PLK41.79680084
24ERBB31.78673053
25WEE11.76863781
26PLK31.72672144
27ATR1.71459275
28CLK11.64896286
29TSSK61.64842890
30EIF2AK11.63872071
31MAP3K51.57057228
32LATS11.51711220
33STK31.47538924
34ATM1.40945663
35STK391.38547325
36CHEK11.38363652
37CDK81.37177275
38CHEK21.35289418
39BUB11.32568155
40OXSR11.29257834
41TGFBR11.25874082
42TRIM281.25687108
43PNCK1.24413550
44CDK71.23487786
45TGFBR21.23478347
46CDK41.22488862
47PAK31.21094371
48EPHA41.20949321
49NUAK11.20051955
50CDK61.13255531
51CDK31.12509976
52MARK31.11619094
53AURKB1.09116796
54PASK1.07613993
55PLK21.07240938
56YES11.07064101
57PLK11.06347563
58MELK1.06160130
59CDK21.05954666
60BMPR1B1.04403296
61MAP2K31.02610390
62DYRK31.01406093
63CDK190.96941826
64STK100.95831744
65DYRK20.94001577
66SGK20.93865106
67PIK3CA0.92508633
68MAP3K100.92156787
69TAF10.91648197
70BRSK20.88498827
71CDK90.87784432
72TXK0.87053979
73FGFR10.86919337
74CDK10.82962733
75GRK70.80624003
76PRPF4B0.79594362
77MAPK130.78519140
78HIPK20.71943601
79ADRBK20.71791426
80BCR0.71066597
81STK38L0.70737256
82MST40.70654830
83STK110.64969717
84BRSK10.62888536
85GSK3B0.62294000
86STK40.61994630
87BMPR20.61563998
88DYRK1A0.61365684
89CSNK1D0.61107394
90MAPK140.60733337
91EIF2AK30.60647894
92MAP3K40.60563155
93MAP2K70.59974921
94CAMK1G0.57343325
95PDK20.57246001
96UHMK10.56284572
97NTRK30.55523774
98PRKDC0.55065212
99RPS6KB10.54303977
100MAPK100.53547359
101MINK10.53052280
102TEC0.52941375
103EIF2AK20.51821817
104NEK60.51100503
105TAOK20.50127138
106SGK4940.49706148
107SGK2230.49706148
108WNK40.48873706
109SGK30.48861453
110KSR10.47968848
111MARK20.46573517
112STK240.46523658
113PRKCE0.45773827
114ALK0.45610161
115CAMK40.45318548
116RPS6KB20.44790972
117CAMK1D0.44172293
118MAPK80.43895356
119CSNK1G10.43723125
120CHUK0.43100613
121PIM10.42495964
122CSNK1E0.42308259
123AKT10.41370599
124CASK0.41100241
125CSNK2A20.39995426
126MAP3K80.39561216
127MAPK70.39467484
128MAPK10.37328194
129GRK10.37236312
130CSNK1A1L0.36975215
131TLK10.36487699
132MTOR0.34649446
133RPS6KA40.33914795
134PRKCQ0.32463804
135CSNK1G20.30648661
136NLK0.30020729
137PBK0.29909228
138PKN10.28739801
139BTK0.25786624

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.05631323
2Mismatch repair_Homo sapiens_hsa034302.92577591
3Homologous recombination_Homo sapiens_hsa034402.82283191
4DNA replication_Homo sapiens_hsa030302.81908350
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.71965154
6Spliceosome_Homo sapiens_hsa030402.69507906
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63539744
8Fanconi anemia pathway_Homo sapiens_hsa034602.63124922
9Cell cycle_Homo sapiens_hsa041102.50081941
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.45506064
11RNA transport_Homo sapiens_hsa030132.42835664
12mRNA surveillance pathway_Homo sapiens_hsa030152.31810775
13RNA polymerase_Homo sapiens_hsa030202.31546947
14Caffeine metabolism_Homo sapiens_hsa002322.27680981
15RNA degradation_Homo sapiens_hsa030182.19778146
16Base excision repair_Homo sapiens_hsa034102.19368263
17Basal transcription factors_Homo sapiens_hsa030222.08489679
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.03507244
19Non-homologous end-joining_Homo sapiens_hsa034502.02930703
20Nucleotide excision repair_Homo sapiens_hsa034201.83514776
21Ether lipid metabolism_Homo sapiens_hsa005651.79404109
22Selenocompound metabolism_Homo sapiens_hsa004501.71418399
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63966515
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63189751
25Propanoate metabolism_Homo sapiens_hsa006401.60044983
26Nitrogen metabolism_Homo sapiens_hsa009101.51679427
27Dorso-ventral axis formation_Homo sapiens_hsa043201.50833999
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45178106
29Linoleic acid metabolism_Homo sapiens_hsa005911.45073244
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37519421
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27274272
32Oocyte meiosis_Homo sapiens_hsa041141.24457780
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17836187
34Herpes simplex infection_Homo sapiens_hsa051681.17084636
35Pyrimidine metabolism_Homo sapiens_hsa002401.15843050
36MicroRNAs in cancer_Homo sapiens_hsa052061.11194222
37Colorectal cancer_Homo sapiens_hsa052101.09594588
38Regulation of autophagy_Homo sapiens_hsa041401.07257084
39p53 signaling pathway_Homo sapiens_hsa041151.03757542
40Epstein-Barr virus infection_Homo sapiens_hsa051691.00439065
41Protein export_Homo sapiens_hsa030600.98283647
42TGF-beta signaling pathway_Homo sapiens_hsa043500.98262973
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97323880
44HTLV-I infection_Homo sapiens_hsa051660.96575158
45One carbon pool by folate_Homo sapiens_hsa006700.96568792
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95307694
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93049091
48Viral carcinogenesis_Homo sapiens_hsa052030.90743973
49Adherens junction_Homo sapiens_hsa045200.89852318
50Small cell lung cancer_Homo sapiens_hsa052220.89570242
51Long-term potentiation_Homo sapiens_hsa047200.89499824
52Primary immunodeficiency_Homo sapiens_hsa053400.88826751
53Hippo signaling pathway_Homo sapiens_hsa043900.88314080
54Lysine degradation_Homo sapiens_hsa003100.87838288
55Systemic lupus erythematosus_Homo sapiens_hsa053220.87824331
56Prostate cancer_Homo sapiens_hsa052150.87098999
57Steroid biosynthesis_Homo sapiens_hsa001000.86710622
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86578728
59Purine metabolism_Homo sapiens_hsa002300.84651103
60Arachidonic acid metabolism_Homo sapiens_hsa005900.83218382
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.81791447
62Wnt signaling pathway_Homo sapiens_hsa043100.79503747
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79485167
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78370753
65Renin secretion_Homo sapiens_hsa049240.77188213
66Chronic myeloid leukemia_Homo sapiens_hsa052200.74994725
67Basal cell carcinoma_Homo sapiens_hsa052170.74779113
68Alcoholism_Homo sapiens_hsa050340.73382661
69Hepatitis B_Homo sapiens_hsa051610.73357200
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72402792
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72115068
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.70127267
73Butanoate metabolism_Homo sapiens_hsa006500.69720972
74Inositol phosphate metabolism_Homo sapiens_hsa005620.69483465
75Pathways in cancer_Homo sapiens_hsa052000.69422922
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68891400
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67575578
78Non-small cell lung cancer_Homo sapiens_hsa052230.67365393
79Olfactory transduction_Homo sapiens_hsa047400.66885622
80beta-Alanine metabolism_Homo sapiens_hsa004100.65729681
81Cocaine addiction_Homo sapiens_hsa050300.65677465
82Morphine addiction_Homo sapiens_hsa050320.65054581
83MAPK signaling pathway_Homo sapiens_hsa040100.64969773
84Phototransduction_Homo sapiens_hsa047440.64696088
85Amphetamine addiction_Homo sapiens_hsa050310.64515625
86B cell receptor signaling pathway_Homo sapiens_hsa046620.64093408
87Notch signaling pathway_Homo sapiens_hsa043300.63713172
88Dopaminergic synapse_Homo sapiens_hsa047280.63334979
89T cell receptor signaling pathway_Homo sapiens_hsa046600.63087860
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62351143
91Hedgehog signaling pathway_Homo sapiens_hsa043400.60255012
92FoxO signaling pathway_Homo sapiens_hsa040680.59567786
93Hematopoietic cell lineage_Homo sapiens_hsa046400.59392405
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59194490
95Taste transduction_Homo sapiens_hsa047420.57794559
96Vitamin digestion and absorption_Homo sapiens_hsa049770.57777770
97Pancreatic cancer_Homo sapiens_hsa052120.57517243
98GABAergic synapse_Homo sapiens_hsa047270.57254022
99Measles_Homo sapiens_hsa051620.56892064
100Nicotine addiction_Homo sapiens_hsa050330.56710170
101Thyroid cancer_Homo sapiens_hsa052160.56565522
102Axon guidance_Homo sapiens_hsa043600.54966121
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54422757
104Long-term depression_Homo sapiens_hsa047300.54057991
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.52934563
106Circadian rhythm_Homo sapiens_hsa047100.52625956
107mTOR signaling pathway_Homo sapiens_hsa041500.52439470
108Endometrial cancer_Homo sapiens_hsa052130.52111024
109Rap1 signaling pathway_Homo sapiens_hsa040150.51904449
110Influenza A_Homo sapiens_hsa051640.51728333
111Circadian entrainment_Homo sapiens_hsa047130.51481871
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50484726
113Choline metabolism in cancer_Homo sapiens_hsa052310.49759178
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49490655
115Melanoma_Homo sapiens_hsa052180.49474872
116Serotonergic synapse_Homo sapiens_hsa047260.47929867
117Glutamatergic synapse_Homo sapiens_hsa047240.47773086
118Tight junction_Homo sapiens_hsa045300.45668958
119ErbB signaling pathway_Homo sapiens_hsa040120.45397271
120Ribosome_Homo sapiens_hsa030100.44901461
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.44126724
122Insulin secretion_Homo sapiens_hsa049110.43618190
123Fatty acid biosynthesis_Homo sapiens_hsa000610.43270095
124Ras signaling pathway_Homo sapiens_hsa040140.43113716
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42074786
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.41759555
127Glioma_Homo sapiens_hsa052140.40266857
128Acute myeloid leukemia_Homo sapiens_hsa052210.39790684
129cAMP signaling pathway_Homo sapiens_hsa040240.39211747
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38570366
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37875116
132Antigen processing and presentation_Homo sapiens_hsa046120.37002596
133Osteoclast differentiation_Homo sapiens_hsa043800.36898614
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36867936
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36785040
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35827253
137Platelet activation_Homo sapiens_hsa046110.35794605
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35267714
139Melanogenesis_Homo sapiens_hsa049160.34962161
140Peroxisome_Homo sapiens_hsa041460.34769410
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30872452
142Salivary secretion_Homo sapiens_hsa049700.30421164
143Tryptophan metabolism_Homo sapiens_hsa003800.30240250
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28967167
145Primary bile acid biosynthesis_Homo sapiens_hsa001200.25505971
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24970422
147GnRH signaling pathway_Homo sapiens_hsa049120.24691602

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