PWWP2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.80921986
2acrosome assembly (GO:0001675)9.47970349
3cell-cell recognition (GO:0009988)9.28878827
4binding of sperm to zona pellucida (GO:0007339)9.19269687
5motile cilium assembly (GO:0044458)8.79049611
6plasma membrane fusion (GO:0045026)8.77647482
7reproduction (GO:0000003)8.39761520
8spermatid development (GO:0007286)8.34245312
9epithelial cilium movement (GO:0003351)8.18713797
10regulation of cilium movement (GO:0003352)8.04547365
11axonemal dynein complex assembly (GO:0070286)8.03598002
12cilium or flagellum-dependent cell motility (GO:0001539)7.31015904
13cilium movement (GO:0003341)6.55339015
14single fertilization (GO:0007338)6.41543285
15sperm capacitation (GO:0048240)6.22626071
16negative regulation of inclusion body assembly (GO:0090084)6.03722220
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.01616605
18organic cation transport (GO:0015695)5.90480174
19spermatogenesis (GO:0007283)5.87775130
20male gamete generation (GO:0048232)5.85485227
21microtubule depolymerization (GO:0007019)5.49171997
22synaptonemal complex organization (GO:0070193)5.44830697
23synaptonemal complex assembly (GO:0007130)5.36199802
24gamete generation (GO:0007276)5.35469704
25male meiosis (GO:0007140)5.27236815
26fertilization (GO:0009566)5.24670872
27calcium ion-dependent exocytosis (GO:0017156)5.20288505
28piRNA metabolic process (GO:0034587)5.05943333
29regulation of inclusion body assembly (GO:0090083)5.01675364
30interferon-gamma secretion (GO:0072643)4.64758156
31cellular process involved in reproduction in multicellular organism (GO:0022412)4.58124061
32germ cell development (GO:0007281)4.55461312
33cell recognition (GO:0008037)4.51470938
34negative regulation of erythrocyte differentiation (GO:0045647)4.50866549
35multicellular organismal reproductive process (GO:0048609)4.27705529
36ventricular system development (GO:0021591)4.27395024
37left/right pattern formation (GO:0060972)4.27015761
38positive regulation of Cdc42 GTPase activity (GO:0043089)4.23369674
39chromosome condensation (GO:0030261)4.21533573
40regulation of microtubule-based movement (GO:0060632)4.20304706
41seminiferous tubule development (GO:0072520)4.14270539
42positive regulation of macrophage activation (GO:0043032)4.12970017
43spermatid nucleus differentiation (GO:0007289)4.10451542
44DNA packaging (GO:0006323)4.05853908
45desmosome organization (GO:0002934)3.96432732
46glycerol ether metabolic process (GO:0006662)3.94560262
47response to peptidoglycan (GO:0032494)3.85850260
48microtubule severing (GO:0051013)3.71104440
49male meiosis I (GO:0007141)3.69578516
50ether metabolic process (GO:0018904)3.62529378
51multicellular organismal development (GO:0007275)3.62485413
52amyloid precursor protein catabolic process (GO:0042987)3.50852580
53DNA methylation involved in gamete generation (GO:0043046)3.47519733
54sexual reproduction (GO:0019953)3.45699889
55epithelial cell differentiation involved in prostate gland development (GO:0060742)3.36572308
56chromosome organization involved in meiosis (GO:0070192)3.35471856
57protein K11-linked deubiquitination (GO:0035871)3.26520552
58mannose metabolic process (GO:0006013)3.20824625
59activation of Rac GTPase activity (GO:0032863)3.15637823
60regulation of leukocyte degranulation (GO:0043300)3.12409990
61protein localization to endosome (GO:0036010)3.12027577
62negative regulation of cell size (GO:0045792)3.10815282
63sequestering of actin monomers (GO:0042989)3.08925097
64chaperone-mediated protein complex assembly (GO:0051131)3.03979834
65barbed-end actin filament capping (GO:0051016)3.02751488
66apoptotic process involved in morphogenesis (GO:0060561)3.02331341
67glycolytic process (GO:0006096)2.98246238
68negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97745320
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94991585
70epithelial cell-cell adhesion (GO:0090136)2.93844698
71meiotic nuclear division (GO:0007126)2.92385017
72regulation of early endosome to late endosome transport (GO:2000641)2.92081517
73regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89460821
74protein polyglutamylation (GO:0018095)2.88935651
75regulation of spindle checkpoint (GO:0090231)2.88238179
76amyloid precursor protein metabolic process (GO:0042982)2.87013079
77regulation of mast cell degranulation (GO:0043304)2.85793905
78neutrophil activation involved in immune response (GO:0002283)2.85459181
79regulation of T-helper 2 cell differentiation (GO:0045628)2.84581708
80positive regulation of icosanoid secretion (GO:0032305)2.81353174
81positive regulation of histone deacetylation (GO:0031065)2.79707695
82response to laminar fluid shear stress (GO:0034616)2.77747160
83peptidyl-tyrosine autophosphorylation (GO:0038083)2.76231866
84polyamine biosynthetic process (GO:0006596)2.76212431
85single strand break repair (GO:0000012)2.75380247
86semaphorin-plexin signaling pathway (GO:0071526)2.74266155
87meiosis I (GO:0007127)2.73288320
88negative regulation of skeletal muscle tissue development (GO:0048642)2.72821555
89positive regulation by symbiont of host defense response (GO:0052509)2.72490756
90modulation by symbiont of host defense response (GO:0052031)2.72490756
91modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.72490756
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.72490756
93positive regulation by organism of defense response of other organism involved in symbiotic interact2.72490756
94modulation by symbiont of host immune response (GO:0052553)2.72490756
95regulation of water loss via skin (GO:0033561)2.72178945
96maternal placenta development (GO:0001893)2.70542735
97glucose catabolic process (GO:0006007)2.70279689
98NIK/NF-kappaB signaling (GO:0038061)2.65945162
99negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.65333751
100negative regulation of granulocyte differentiation (GO:0030853)2.64071175
101response to muramyl dipeptide (GO:0032495)2.63884589
102RNA destabilization (GO:0050779)2.63484242
103hemidesmosome assembly (GO:0031581)2.62350464
104protein localization to cilium (GO:0061512)2.61068420
105positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.60244918
106pinocytosis (GO:0006907)2.59783197
107mitotic sister chromatid cohesion (GO:0007064)2.59587624
108sodium-independent organic anion transport (GO:0043252)2.59368897
109cell-cell junction maintenance (GO:0045217)2.59251373
110regulation of regulated secretory pathway (GO:1903305)2.58837745
111atrioventricular valve morphogenesis (GO:0003181)2.57578367
112macrophage activation involved in immune response (GO:0002281)2.54009615
113embryonic heart tube development (GO:0035050)2.53863327
114genitalia morphogenesis (GO:0035112)2.53411362
115phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.52567905
116membrane protein intracellular domain proteolysis (GO:0031293)2.52068358
117pentose-phosphate shunt (GO:0006098)2.51573127
118negative regulation of cell killing (GO:0031342)2.51552615
119negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.51552615
120cellular response to thyroid hormone stimulus (GO:0097067)2.51311894
121positive regulation of protein deacetylation (GO:0090312)2.50706780
122stress fiber assembly (GO:0043149)2.50680180
123natural killer cell mediated immunity (GO:0002228)2.50572247
124natural killer cell mediated cytotoxicity (GO:0042267)2.50572247
125modulation by symbiont of host cellular process (GO:0044068)2.49460819
126adherens junction assembly (GO:0034333)2.48832859
127cell-substrate adherens junction assembly (GO:0007045)2.48732247
128focal adhesion assembly (GO:0048041)2.48732247
129detection of bacterium (GO:0016045)2.48309440
130modulation by virus of host process (GO:0019054)2.46909825
131nucleoside diphosphate phosphorylation (GO:0006165)2.43903609
132dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.43780057
133vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.43461506
134regulation of cilium assembly (GO:1902017)2.42948355
135negative regulation of fatty acid transport (GO:2000192)2.42315156
136intracellular estrogen receptor signaling pathway (GO:0030520)2.42223843
137regulation of ARF GTPase activity (GO:0032312)2.41723391
138positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.41697122
139regulation of mast cell activation involved in immune response (GO:0033006)2.41356789
140detection of other organism (GO:0098543)2.40794881
141regulation of fatty acid beta-oxidation (GO:0031998)2.40136539
142cytoskeletal anchoring at plasma membrane (GO:0007016)2.38094980
143positive regulation of receptor recycling (GO:0001921)2.37342210
144energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.35456327
145ATP hydrolysis coupled proton transport (GO:0015991)2.35456327
146protein refolding (GO:0042026)2.34797836
147negative regulation of viral release from host cell (GO:1902187)2.34565916
148regulation of viral release from host cell (GO:1902186)2.34498545
149response to acidic pH (GO:0010447)2.34225404
150regulation of necrotic cell death (GO:0010939)2.32627464
151hypotonic response (GO:0006971)2.32329566
152negative regulation of glial cell proliferation (GO:0060253)2.32127262
153activation of JUN kinase activity (GO:0007257)2.31686770
154regulation of mammary gland epithelial cell proliferation (GO:0033599)2.31675149
155regulation of Cdc42 GTPase activity (GO:0043088)2.30753149
156RNA localization (GO:0006403)2.30722731
157positive regulation of fatty acid transport (GO:2000193)2.30602379
158antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.29243707
159negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.29047554
160polyol catabolic process (GO:0046174)2.27570769
161Rho protein signal transduction (GO:0007266)2.27055548
162positive regulation of keratinocyte differentiation (GO:0045618)2.26541603
163regulation of cholesterol storage (GO:0010885)2.26170344
164lipopolysaccharide-mediated signaling pathway (GO:0031663)2.25995859
165microtubule polymerization or depolymerization (GO:0031109)2.25625792
166regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.25315302
167regulation of glucose import in response to insulin stimulus (GO:2001273)2.24590547
168response to thyroid hormone (GO:0097066)2.24460671
169branching involved in mammary gland duct morphogenesis (GO:0060444)2.24233985
170calcium ion import (GO:0070509)2.23882760
171activation of MAPKKK activity (GO:0000185)2.23839330
172positive regulation of prostaglandin secretion (GO:0032308)2.23394951
173cell-substrate junction assembly (GO:0007044)2.23284979
174endothelial cell chemotaxis (GO:0035767)2.23115022
175germinal center formation (GO:0002467)2.21853826
176cilium organization (GO:0044782)2.21624208
177negative regulation of toll-like receptor signaling pathway (GO:0034122)2.21257756
178positive regulation of endothelial cell differentiation (GO:0045603)2.20871677
179amino-acid betaine transport (GO:0015838)2.20186042
180carnitine transport (GO:0015879)2.20186042
181cellular response to arsenic-containing substance (GO:0071243)2.19792905
182peptidyl-proline hydroxylation (GO:0019511)2.19373850
183positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.19354243
184antigen processing and presentation of endogenous antigen (GO:0019883)2.19051140
185positive regulation of leukocyte degranulation (GO:0043302)2.18246276
186regulation of protein kinase C signaling (GO:0090036)2.18098203
187establishment of apical/basal cell polarity (GO:0035089)2.17966127
188GTP biosynthetic process (GO:0006183)2.17804294
189modulation by virus of host morphology or physiology (GO:0019048)2.17353001
190glycosphingolipid catabolic process (GO:0046479)2.16789861
191microglial cell activation (GO:0001774)2.16762842
192cellular component assembly involved in morphogenesis (GO:0010927)2.16685124
193endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.15843173
194sperm motility (GO:0030317)12.7179978
195acrosome reaction (GO:0007340)11.8903997
196fusion of sperm to egg plasma membrane (GO:0007342)11.3343985
197cell wall macromolecule catabolic process (GO:0016998)10.8918489
198cell wall macromolecule metabolic process (GO:0044036)10.8918489
199sperm-egg recognition (GO:0035036)10.2678799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.21552024
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.51225731
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.46219070
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.40073110
5EZH2_22144423_ChIP-Seq_EOC_Human3.21821884
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.18833616
7VDR_21846776_ChIP-Seq_THP-1_Human2.98967483
8LXR_22292898_ChIP-Seq_THP-1_Human2.93018540
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.71160090
10* RACK7_27058665_Chip-Seq_MCF-7_Human2.61238706
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.60872116
12* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.56098388
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43353744
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42105280
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.39753443
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.39431069
17ZNF274_21170338_ChIP-Seq_K562_Hela2.39207291
18* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.35540764
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32164417
20ZNF263_19887448_ChIP-Seq_K562_Human2.19892515
21MYC_22102868_ChIP-Seq_BL_Human2.18769717
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.17258135
23TCF7_22412390_ChIP-Seq_EML_Mouse2.14458332
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.10534431
25* KDM2B_26808549_Chip-Seq_DND41_Human2.08579460
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07523218
27GATA1_26923725_Chip-Seq_HPCs_Mouse2.06454170
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.00338927
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94242816
30VDR_24763502_ChIP-Seq_THP-1_Human1.88455911
31VDR_22108803_ChIP-Seq_LS180_Human1.85826086
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.84822355
33KDM2B_26808549_Chip-Seq_K562_Human1.83099348
34P68_20966046_ChIP-Seq_HELA_Human1.82748476
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.70541077
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66972098
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66465414
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.65482034
39SA1_27219007_Chip-Seq_ERYTHROID_Human1.64595834
40* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.63529741
41ELK4_26923725_Chip-Seq_MESODERM_Mouse1.63469639
42SMC4_20622854_ChIP-Seq_HELA_Human1.63418773
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.63317104
44* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60146808
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.56555341
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56411709
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56019053
48CREB1_26743006_Chip-Seq_LNCaP_Human1.51842746
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51402833
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50757539
51STAT1_17558387_ChIP-Seq_HELA_Human1.50150677
52MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.50107374
53* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49964496
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44664349
55BCOR_27268052_Chip-Seq_Bcells_Human1.42184352
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41648341
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41421365
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38732650
59TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.37999779
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.37911023
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.37589346
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36918729
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.34602268
64* MAF_26560356_Chip-Seq_TH1_Human1.34110443
65BCL6_27268052_Chip-Seq_Bcells_Human1.33883572
66* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32552885
67GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.31967589
68VDR_24787735_ChIP-Seq_THP-1_Human1.31308054
69GF1_26923725_Chip-Seq_HPCs_Mouse1.31063160
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30850705
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30243469
72GATA3_21867929_ChIP-Seq_CD8_Mouse1.29653376
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29102162
74SCL_19346495_ChIP-Seq_HPC-7_Human1.28285679
75MAF_26560356_Chip-Seq_TH2_Human1.27407511
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26168695
77CTCF_27219007_Chip-Seq_Bcells_Human1.25394956
78RAD21_21589869_ChIP-Seq_MESCs_Mouse1.25105684
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24781367
80FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24630270
81FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24443832
82KDM2B_26808549_Chip-Seq_REH_Human1.23451647
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23216167
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23061458
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.22924300
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21020394
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20277241
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20244796
89ATF3_27146783_Chip-Seq_COLON_Human1.19903784
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19218822
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18336627
92IRF8_27001747_Chip-Seq_BMDM_Mouse1.17569583
93UTX_26944678_Chip-Seq_JUKART_Human1.17039273
94NCOR1_26117541_ChIP-Seq_K562_Human1.15921383
95SOX2_22085726_ChIP-Seq_NPCs_Mouse1.15767523
96CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15482700
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15388328
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15263356
99CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14846506
100* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14258617
101* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13743410
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.13518853
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13043190
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12872947
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12011162
106RXR_22158963_ChIP-Seq_LIVER_Mouse1.11796400
107ESR1_20079471_ChIP-ChIP_T-47D_Human1.10569523
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10172443
109* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10077866
110WDR5_24793694_ChIP-Seq_LNCAP_Human1.10014649
111LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.10000662
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09889248
113IRF8_22096565_ChIP-ChIP_GC-B_Human1.09699096
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08621874
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08579245
116* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08103731
117NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07857858
118CTCF_26484167_Chip-Seq_Bcells_Mouse1.07330083
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07179698
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07177347
121SPI1_23127762_ChIP-Seq_K562_Human1.06836238
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06797607
123FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06291268
124* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06196367
125SA1_27219007_Chip-Seq_Bcells_Human1.05879388
126* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05776841
127PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05137170
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05066245
129* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04787290
130EP300_21415370_ChIP-Seq_HL-1_Mouse1.04538870
131PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03680854
132JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03264430
133PHF8_20622854_ChIP-Seq_HELA_Human1.03018293
134P53_21459846_ChIP-Seq_SAOS-2_Human1.02913229
135GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02825168
136E2F1_20622854_ChIP-Seq_HELA_Human1.01904752
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01786590
138SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01269069
139FLI1_21867929_ChIP-Seq_TH2_Mouse1.01013015
140NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00807369
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00238372
142VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99660926
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97233641
144IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97103119
145CBP_20019798_ChIP-Seq_JUKART_Human0.97103119
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96863787
147TET1_21451524_ChIP-Seq_MESCs_Mouse0.95753119
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95690513
149CTCF_20526341_ChIP-Seq_ESCs_Human0.95509868
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95327929
151STAT3_18555785_ChIP-Seq_MESCs_Mouse0.94992215
152AHR_22903824_ChIP-Seq_MCF-7_Human0.94645727
153TAL1_26923725_Chip-Seq_HPCs_Mouse0.94183458
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.94126363
155MYC_27129775_Chip-Seq_CORNEA_Mouse0.93643058
156GATA3_21867929_ChIP-Seq_TH1_Mouse0.93509041
157SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93383023
158NFE2_27457419_Chip-Seq_LIVER_Mouse0.93031524
159TAF15_26573619_Chip-Seq_HEK293_Human0.92630901
160EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90868429
161P53_22387025_ChIP-Seq_ESCs_Mouse0.90644195
162* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90485484
163JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.90192276
164TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90033972
165POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90033972
166* TP63_22573176_ChIP-Seq_HFKS_Human0.89101359
167CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88906040
168* TBX20_22080862_ChIP-Seq_HEART_Mouse0.87486943
169* TBX20_22328084_ChIP-Seq_HEART_Mouse0.87486943
170NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86637834
171KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86554474
172ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86098472
173PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85894937
174SMAD3_21741376_ChIP-Seq_ESCs_Human0.85833529
175ARNT_22903824_ChIP-Seq_MCF-7_Human0.85168407
176* RAC3_21632823_ChIP-Seq_H3396_Human0.85157401
177CSB_26484114_Chip-Seq_FIBROBLAST_Human0.84394469
178GF1B_26923725_Chip-Seq_HPCs_Mouse0.84216297
179ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84144942
180RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84038607
181SPI1_26923725_Chip-Seq_HPCs_Mouse0.82960442
182NANOG_18555785_Chip-Seq_ESCs_Mouse0.81335726
183BP1_19119308_ChIP-ChIP_Hs578T_Human0.81327544
184* RUNX1_27514584_Chip-Seq_MCF-7_Human0.81218763
185REST_21632747_ChIP-Seq_MESCs_Mouse0.80092542
186RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80046450
187* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78180172
188OCT4_18555785_Chip-Seq_ESCs_Mouse0.77773244
189SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77360624
190MYC_19829295_ChIP-Seq_ESCs_Human0.77208350
191ELF1_20517297_ChIP-Seq_JURKAT_Human0.77053204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.77910262
2MP0001929_abnormal_gametogenesis4.00563166
3MP0010234_abnormal_vibrissa_follicle3.88327505
4MP0005451_abnormal_body_composition3.44861215
5MP0008877_abnormal_DNA_methylation3.25095950
6MP0005670_abnormal_white_adipose2.89346490
7MP0004185_abnormal_adipocyte_glucose2.57968182
8MP0003191_abnormal_cellular_cholesterol2.53633731
9MP0002161_abnormal_fertility/fecundity2.44962261
10MP0003303_peritoneal_inflammation2.39238555
11MP0005623_abnormal_meninges_morphology2.36358425
12MP0009278_abnormal_bone_marrow2.30724755
13MP0004858_abnormal_nervous_system2.24179591
14MP0002210_abnormal_sex_determination2.22565844
15MP0003453_abnormal_keratinocyte_physiol2.15791302
16MP0009840_abnormal_foam_cell2.13382037
17MP0000569_abnormal_digit_pigmentation2.12860925
18MP0008260_abnormal_autophagy2.11616484
19MP0004264_abnormal_extraembryonic_tissu2.08244925
20MP0005666_abnormal_adipose_tissue2.06309463
21MP0005410_abnormal_fertilization14.2832770
22MP0001145_abnormal_male_reproductive1.91971947
23MP0001849_ear_inflammation1.79568103
24MP0004947_skin_inflammation1.67954440
25MP0004381_abnormal_hair_follicle1.66094995
26MP0000678_abnormal_parathyroid_gland1.62871262
27MP0005501_abnormal_skin_physiology1.59965744
28MP0001873_stomach_inflammation1.58361863
29MP0005375_adipose_tissue_phenotype1.56911453
30MP0002098_abnormal_vibrissa_morphology1.56179504
31MP0003123_paternal_imprinting1.54757513
32MP0000653_abnormal_sex_gland1.50054245
33MP0002736_abnormal_nociception_after1.45068797
34MP0002653_abnormal_ependyma_morphology1.44708933
35MP0003075_altered_response_to1.39503814
36MP0002234_abnormal_pharynx_morphology1.38628445
37MP0005083_abnormal_biliary_tract1.38250286
38MP0003183_abnormal_peptide_metabolism1.37926298
39MP0005025_abnormal_response_to1.36959720
40MP0003566_abnormal_cell_adhesion1.35388856
41MP0010155_abnormal_intestine_physiology1.35253229
42MP0000534_abnormal_ureter_morphology1.35042481
43MP0009333_abnormal_splenocyte_physiolog1.34154252
44MP0001765_abnormal_ion_homeostasis1.32775872
45MP0002249_abnormal_larynx_morphology1.30109711
46MP0004233_abnormal_muscle_weight1.29419146
47MP0005058_abnormal_lysosome_morphology1.28876197
48MP0003828_pulmonary_edema1.28598583
49MP0003279_aneurysm1.23426130
50MP0005464_abnormal_platelet_physiology1.22317167
51MP0005397_hematopoietic_system_phenotyp1.21520118
52MP0001545_abnormal_hematopoietic_system1.21520118
53MP0000015_abnormal_ear_pigmentation1.15770506
54MP0005367_renal/urinary_system_phenotyp1.15400907
55MP0000516_abnormal_urinary_system1.15400907
56MP0001533_abnormal_skeleton_physiology1.15327913
57MP0000566_synostosis1.15053021
58MP0003329_amyloid_beta_deposits1.14092897
59MP0003950_abnormal_plasma_membrane1.12568773
60MP0001216_abnormal_epidermal_layer1.12280083
61MP0010368_abnormal_lymphatic_system1.11678438
62MP0004510_myositis1.02406448
63MP0003646_muscle_fatigue1.00952916
64MP0003724_increased_susceptibility_to0.99180353
65MP0005409_darkened_coat_color0.97812761
66MP0001790_abnormal_immune_system0.97229878
67MP0005387_immune_system_phenotype0.97229878
68MP0005000_abnormal_immune_tolerance0.97204010
69MP0000858_altered_metastatic_potential0.97010961
70MP0004084_abnormal_cardiac_muscle0.96930539
71MP0000681_abnormal_thyroid_gland0.96166786
72MP0004036_abnormal_muscle_relaxation0.96121605
73MP0002877_abnormal_melanocyte_morpholog0.95013732
74MP0004130_abnormal_muscle_cell0.93955678
75MP0001346_abnormal_lacrimal_gland0.93536591
76MP0003866_abnormal_defecation0.93370524
77MP0000751_myopathy0.92621503
78MP0000490_abnormal_crypts_of0.92378602
79MP0000003_abnormal_adipose_tissue0.91690976
80MP0000604_amyloidosis0.91619680
81MP0002295_abnormal_pulmonary_circulatio0.90527973
82MP0001984_abnormal_olfaction0.90467057
83MP0009931_abnormal_skin_appearance0.90369788
84MP0005166_decreased_susceptibility_to0.88862729
85MP0005257_abnormal_intraocular_pressure0.88784758
86MP0001819_abnormal_immune_cell0.88533225
87MP0008004_abnormal_stomach_pH0.88255393
88MP0000467_abnormal_esophagus_morphology0.87514237
89MP0002420_abnormal_adaptive_immunity0.87110852
90MP0010386_abnormal_urinary_bladder0.86733698
91MP0005174_abnormal_tail_pigmentation0.86538982
92MP0002160_abnormal_reproductive_system0.86453854
93MP0003115_abnormal_respiratory_system0.86167049
94MP0003763_abnormal_thymus_physiology0.85910017
95MP0001851_eye_inflammation0.85141479
96MP0002796_impaired_skin_barrier0.84961204
97MP0004272_abnormal_basement_membrane0.84763748
98MP0002452_abnormal_antigen_presenting0.84595088
99MP0006082_CNS_inflammation0.84593336
100MP0000747_muscle_weakness0.84032718
101MP0002723_abnormal_immune_serum0.81933647
102MP0001958_emphysema0.81763207
103MP0002971_abnormal_brown_adipose0.80685322
104MP0003705_abnormal_hypodermis_morpholog0.80064454
105MP0001835_abnormal_antigen_presentation0.79714815
106MP0000749_muscle_degeneration0.77945951
107MP0000537_abnormal_urethra_morphology0.77448106
108MP0002282_abnormal_trachea_morphology0.76273529
109MP0000377_abnormal_hair_follicle0.76130636
110MP0000733_abnormal_muscle_development0.75918333
111MP0000470_abnormal_stomach_morphology0.75015161
112MP0010678_abnormal_skin_adnexa0.74495824
113MP0004808_abnormal_hematopoietic_stem0.74161762
114MP0003879_abnormal_hair_cell0.73623184
115MP0000579_abnormal_nail_morphology0.73591528
116MP0003448_altered_tumor_morphology0.73229370
117MP0005390_skeleton_phenotype0.73154073
118MP0000759_abnormal_skeletal_muscle0.72803926
119MP0001845_abnormal_inflammatory_respons0.72322593
120MP0000750_abnormal_muscle_regeneration0.71929171
121MP0010771_integument_phenotype0.71698363
122MP0008469_abnormal_protein_level0.71506535
123MP0002419_abnormal_innate_immunity0.69314941
124MP0002822_catalepsy0.68781785
125MP0008995_early_reproductive_senescence0.67590850
126MP0001879_abnormal_lymphatic_vessel0.67303969
127MP0003045_fibrosis0.64192226
128MP0003091_abnormal_cell_migration0.63527368
129MP0001324_abnormal_eye_pigmentation0.61887076
130MP0009046_muscle_twitch0.61613406
131MP0003300_gastrointestinal_ulcer0.60109238
132MP0001727_abnormal_embryo_implantation0.58877771
133MP0002060_abnormal_skin_morphology0.57915413
134MP0005275_abnormal_skin_tensile0.54311905
135MP0001968_abnormal_touch/_nociception0.52134197
136MP0004782_abnormal_surfactant_physiolog0.51804180
137MP0009764_decreased_sensitivity_to0.51477124
138MP0005023_abnormal_wound_healing0.50754169
139MP0001188_hyperpigmentation0.50739360
140MP0003942_abnormal_urinary_system0.50391064
141MP0002405_respiratory_system_inflammati0.50277935
142MP0000249_abnormal_blood_vessel0.49183383
143MP0004085_abnormal_heartbeat0.48735648
144MP0005595_abnormal_vascular_smooth0.47524047
145MP0005388_respiratory_system_phenotype0.46897241
146MP0002133_abnormal_respiratory_system0.46897241
147MP0003787_abnormal_imprinting0.46749542
148MP0005167_abnormal_blood-brain_barrier0.45992805
149MP0002148_abnormal_hypersensitivity_rea0.45031555
150MP0003172_abnormal_lysosome_physiology0.44900051
151MP0000767_abnormal_smooth_muscle0.44440682
152MP0003878_abnormal_ear_physiology0.43822867
153MP0005377_hearing/vestibular/ear_phenot0.43822867
154MP0008438_abnormal_cutaneous_collagen0.43484555
155MP0000343_altered_response_to0.43096337
156MP0002132_abnormal_respiratory_system0.43071910
157MP0005310_abnormal_salivary_gland0.42066054
158MP0004484_altered_response_of0.41775698
159MP0005076_abnormal_cell_differentiation0.40719946
160MP0002998_abnormal_bone_remodeling0.40230767
161MP0005389_reproductive_system_phenotype0.39531735
162MP0003436_decreased_susceptibility_to0.38795355
163MP0003786_premature_aging0.37064305
164MP0005647_abnormal_sex_gland0.36035770
165MP0009785_altered_susceptibility_to0.35273631
166MP0004811_abnormal_neuron_physiology0.34959524
167MP0002135_abnormal_kidney_morphology0.34748119

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)7.56268425
2Abnormal respiratory motile cilium morphology (HP:0005938)7.56268425
3Abnormal respiratory motile cilium physiology (HP:0012261)7.38739916
4Infertility (HP:0000789)6.10767079
5Chronic bronchitis (HP:0004469)5.92995833
6Abnormal ciliary motility (HP:0012262)5.86936312
7Rhinitis (HP:0012384)5.74133778
8Nasal polyposis (HP:0100582)5.55441452
9Abnormality of the nasal mucosa (HP:0000433)4.99165178
10Male infertility (HP:0003251)4.95105093
11Nephronophthisis (HP:0000090)3.58974127
12Bronchitis (HP:0012387)3.56378403
13Increased cerebral lipofuscin (HP:0011813)3.53512908
14Bronchiectasis (HP:0002110)3.44243310
15Tubular atrophy (HP:0000092)3.35999955
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.27491391
17Abnormal spermatogenesis (HP:0008669)3.24145537
18Choroideremia (HP:0001139)3.19856716
19Eczematoid dermatitis (HP:0000976)3.19827158
20Dysostosis multiplex (HP:0000943)3.09910742
21Increased connective tissue (HP:0009025)3.00107780
22Axonal loss (HP:0003447)2.92360241
23Abnormality of glycolipid metabolism (HP:0010969)2.86961256
24Abnormality of liposaccharide metabolism (HP:0010968)2.86961256
25Abnormality of glycosphingolipid metabolism (HP:0004343)2.86961256
26Exercise-induced myalgia (HP:0003738)2.86167732
27Abnormality of the renal medulla (HP:0100957)2.80487918
28Stridor (HP:0010307)2.77552659
29Abnormality of macrophages (HP:0004311)2.75614643
30Broad face (HP:0000283)2.69102736
31Obstructive sleep apnea (HP:0002870)2.63560768
32Congenital malformation of the right heart (HP:0011723)2.59347665
33Double outlet right ventricle (HP:0001719)2.59347665
34Flat acetabular roof (HP:0003180)2.57434440
35Dyschromatopsia (HP:0007641)2.57275637
36Thin bony cortex (HP:0002753)2.53648702
37Mucopolysacchariduria (HP:0008155)2.47053816
38Urinary glycosaminoglycan excretion (HP:0003541)2.47053816
39Abnormality of polysaccharide metabolism (HP:0011012)2.44495696
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.44495696
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.44495696
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.44173405
43Recurrent bacterial skin infections (HP:0005406)2.37948686
44Recurrent otitis media (HP:0000403)2.36995666
45Cellulitis (HP:0100658)2.33205613
46Tubulointerstitial nephritis (HP:0001970)2.32210755
47Short nail (HP:0001799)2.31080341
48Vertebral compression fractures (HP:0002953)2.30989844
49Hypercortisolism (HP:0001578)2.28074085
50Colitis (HP:0002583)2.25768656
51Bell-shaped thorax (HP:0001591)2.24898481
52Milia (HP:0001056)2.24454360
53Stage 5 chronic kidney disease (HP:0003774)2.24417017
54Achilles tendon contracture (HP:0001771)2.23720142
55Abnormality of the distal phalanges of the toes (HP:0010182)2.22267658
56Mildly elevated creatine phosphokinase (HP:0008180)2.20993604
57Hyperparathyroidism (HP:0000843)2.20144430
58Cervical subluxation (HP:0003308)2.16729809
59Cerebral aneurysm (HP:0004944)2.16442864
60Malnutrition (HP:0004395)2.16380773
61Bulbar palsy (HP:0001283)2.16296385
62Upper limb muscle weakness (HP:0003484)2.15616419
63Gingivitis (HP:0000230)2.15576487
64Hyperacusis (HP:0010780)2.13980426
65Weak cry (HP:0001612)2.12634056
66Myopathic facies (HP:0002058)2.12160164
67Polygenic inheritance (HP:0010982)2.11872149
68Thoracic kyphosis (HP:0002942)2.11409530
69Difficulty climbing stairs (HP:0003551)2.10209546
70Abnormality of the renal cortex (HP:0011035)2.10020744
71Germ cell neoplasia (HP:0100728)2.08428539
72Abnormality of the thoracic spine (HP:0100711)2.08108507
73Growth hormone excess (HP:0000845)2.04034927
74Tubulointerstitial abnormality (HP:0001969)2.03594231
75Increased serum ferritin (HP:0003281)2.02952513
76Interstitial pulmonary disease (HP:0006530)2.00690311
77Dynein arm defect of respiratory motile cilia (HP:0012255)11.3310556
78Absent/shortened dynein arms (HP:0200106)11.3310556
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.3409134
80Impulsivity (HP:0100710)1.99961604
81Hypertriglyceridemia (HP:0002155)1.99790043
82Recurrent bronchitis (HP:0002837)1.98633449
83Pili torti (HP:0003777)1.97921809
84Retrobulbar optic neuritis (HP:0100654)1.97781352
85Optic neuritis (HP:0100653)1.97781352
86Orchitis (HP:0100796)1.96934392
87Recurrent sinusitis (HP:0011108)1.96855555
88Generalized muscle weakness (HP:0003324)1.96199751
89Acanthosis nigricans (HP:0000956)1.96130228
90Distal lower limb amyotrophy (HP:0008944)1.95869971
91Testicular neoplasm (HP:0010788)1.95802558
92Ragged-red muscle fibers (HP:0003200)1.94904809
93Atelectasis (HP:0100750)1.94606756
94Loss of speech (HP:0002371)1.94178980
95Gastrointestinal inflammation (HP:0004386)1.93615177
96Tubulointerstitial fibrosis (HP:0005576)1.93184603
97Absent frontal sinuses (HP:0002688)1.92867823
98Abnormality of the Achilles tendon (HP:0005109)1.91536165
99Asymmetric septal hypertrophy (HP:0001670)1.91484582
100Abnormal vertebral ossification (HP:0100569)1.91131167
101Amyloidosis (HP:0011034)1.89647532
102Spinal rigidity (HP:0003306)1.89244438
103Pathologic fracture (HP:0002756)1.89068481
104Vacuolated lymphocytes (HP:0001922)1.88513735
105Chronic obstructive pulmonary disease (HP:0006510)1.87119723
106Obstructive lung disease (HP:0006536)1.87119723
107J-shaped sella turcica (HP:0002680)1.86627695
108Distal lower limb muscle weakness (HP:0009053)1.86488252
109Azoospermia (HP:0000027)1.86444156
110Neuronal loss in central nervous system (HP:0002529)1.85550875
111Diaphragmatic weakness (HP:0009113)1.83556701
112Fatigable weakness (HP:0003473)1.83210235
113Abnormality of the neuromuscular junction (HP:0003398)1.83210235
114Spinal cord compression (HP:0002176)1.82179233
115Increased variability in muscle fiber diameter (HP:0003557)1.81776770
116Abdominal distention (HP:0003270)1.81155005
117Myositis (HP:0100614)1.80533164
118Muscle fiber splitting (HP:0003555)1.80283991
119Asymmetry of the thorax (HP:0001555)1.79492750
120Increased IgE level (HP:0003212)1.78989496
121Abnormality of skeletal muscle fiber size (HP:0012084)1.78746415
122Gonadotropin excess (HP:0000837)1.78110555
123Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77926406
124Abnormal gallbladder physiology (HP:0012438)1.76961916
125Cholecystitis (HP:0001082)1.76961916
126Abnormality of carpal bone ossification (HP:0006257)1.76448136
127Bone pain (HP:0002653)1.75436043
128Bundle branch block (HP:0011710)1.75198029
129Tetraparesis (HP:0002273)1.74506332
130Lymphangioma (HP:0100764)1.73845795
131Hand muscle atrophy (HP:0009130)1.73774473
132Exercise-induced muscle cramps (HP:0003710)1.72511161
133Recurrent gram-negative bacterial infections (HP:0005420)1.71946222
134Decreased central vision (HP:0007663)1.71749894
135Advanced eruption of teeth (HP:0006288)1.70557180
136Inflammation of the large intestine (HP:0002037)1.69712694
137Centrally nucleated skeletal muscle fibers (HP:0003687)1.68697438
138Hypoplasia of dental enamel (HP:0006297)1.68312429
139Aortic aneurysm (HP:0004942)1.67601690
140Mediastinal lymphadenopathy (HP:0100721)1.66569156
141Distal upper limb amyotrophy (HP:0007149)1.66553037
142Upper limb amyotrophy (HP:0009129)1.66553037
143Nonprogressive disorder (HP:0003680)1.66306473
144Constricted visual fields (HP:0001133)1.65765979
145Nuclear cataract (HP:0100018)1.65424446
146Neurofibrillary tangles (HP:0002185)1.65302035
147High pitched voice (HP:0001620)1.64517977
148Cardiomegaly (HP:0001640)1.64493758
149Abnormality of dentin (HP:0010299)1.63483599
150Ulnar deviation of the wrist (HP:0003049)1.63472812
151Right ventricular cardiomyopathy (HP:0011663)1.61624319
152Testicular atrophy (HP:0000029)1.59333028
153Glucose intolerance (HP:0000833)1.58312166
154Abnormality of midbrain morphology (HP:0002418)1.58029013
155Molar tooth sign on MRI (HP:0002419)1.58029013
156Deformed sella turcica (HP:0002681)1.57972049
157Lower limb amyotrophy (HP:0007210)1.54104561
158Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.53830209
159Decreased electroretinogram (ERG) amplitude (HP:0000654)1.52293706
160Disinhibition (HP:0000734)1.51365063
161Retinal atrophy (HP:0001105)1.51359776
162Facial diplegia (HP:0001349)1.51019563
163Prostate neoplasm (HP:0100787)1.48863327
164Atrophic scars (HP:0001075)1.47814922
165Long foot (HP:0001833)1.45897944
166Hemorrhage of the eye (HP:0011885)1.43758827
167Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.43198072
168Fragile nails (HP:0001808)1.42686215
169Abnormality of the dental root (HP:0006486)1.42468247
170Taurodontia (HP:0000679)1.42468247
171Abnormality of permanent molar morphology (HP:0011071)1.42468247
172Easy fatigability (HP:0003388)1.42138366
173Heterotopia (HP:0002282)1.41964871
174Recurrent abscess formation (HP:0002722)1.37203953
175Onycholysis (HP:0001806)1.37134363
176Hyporeflexia of lower limbs (HP:0002600)1.35665395
177Abnormality of molar (HP:0011077)1.34983610
178Abnormality of molar morphology (HP:0011070)1.34983610

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK16.51599581
2PDK46.06916405
3PDK36.06916405
4PRKD35.40498955
5PDK24.56681399
6ICK3.57330978
7SIK13.46015996
8PTK2B2.96851692
9IRAK32.72354273
10PRPF4B2.54567074
11SMG12.45549902
12NME22.34669594
13RIPK42.30556669
14STK382.29015707
15CAMK1G2.27233208
16CAMKK22.16650535
17PKN22.15341955
18CAMK1D2.09607729
19TAOK11.84277100
20MAP2K31.84199950
21MAP3K41.71627967
22MAP2K71.70744863
23MAP3K111.66878176
24MYLK1.65605915
25STK38L1.61974356
26EPHA21.60074529
27TAOK21.51642726
28AKT31.51398906
29MAP4K11.41875447
30WNK41.41066999
31CAMKK11.37375424
32MAP3K11.32539638
33PRKD21.31300957
34MARK21.30883711
35EPHB11.23676742
36TNK21.21175818
37IRAK41.19371403
38IRAK21.18047602
39GRK61.07592153
40TTN1.06233083
41CSK1.05286010
42STK391.04846211
43MAP3K131.04804375
44TESK20.97420821
45DYRK1B0.97287254
46CDK30.94596005
47PDK10.86197208
48FER0.86011223
49CDC42BPA0.83749441
50PTK60.82974707
51MAPKAPK30.81537086
52ARAF0.80681740
53MUSK0.79944149
54MAP3K20.77902552
55PDPK10.77593622
56HIPK20.76738818
57PNCK0.76711538
58LRRK20.75713761
59RPS6KA40.75702594
60TBK10.75468354
61MAP3K60.73593006
62DDR20.69064562
63MAP3K100.68983550
64PAK40.68215927
65RIPK10.67776561
66MAP3K70.67673120
67MAP3K30.67189160
68MAPK120.66809473
69EEF2K0.66354854
70TRPM70.65570049
71MAP2K40.65467715
72WNK10.64865065
73CSF1R0.64655685
74CDK80.63752969
75FGFR40.63286945
76ILK0.61785811
77MATK0.60786686
78LMTK20.60677029
79ABL20.60111236
80BLK0.59658103
81BTK0.58943262
82NEK20.57533901
83TRIB30.56456289
84KSR20.54503090
85CAMK10.54015567
86STK30.52288373
87ZAK0.52079936
88STK240.49826016
89SCYL20.49043687
90PAK20.49005179
91BMPR20.48695269
92PRKG20.48101189
93PRKCI0.47474993
94LATS20.47283958
95SIK20.46217611
96CDK120.45672472
97EPHB20.44265563
98EPHA40.41915152
99RPS6KA20.41186547
100GRK10.41002315
101NME10.40834118
102IKBKB0.40018128
103CHUK0.38983984
104MAP2K10.38796387
105MAP3K80.36918295
106ERN10.36744372
107MAPK70.36652508
108PAK10.35568728
109MAPK40.35317862
110CAMK2G0.34889623
111PRKAA20.34208115
112BRAF0.32846386
113MAP2K60.32017582
114MAPK110.31990087
115DMPK0.31943356
116DAPK20.31262248
117MAP3K140.31191148
118RPS6KB20.28601376
119PRKCG0.28428586
120MAP2K20.28226639
121IRAK10.28181760
122TGFBR20.28164703
123FES0.26806794
124TIE10.25806071
125PINK10.20499224
126CAMK40.19283674
127PRKCD0.17395522
128KIT0.16691199
129MAPK150.16426447
130BMX0.16105833
131RPS6KC10.15879363
132RPS6KL10.15879363
133MTOR0.14963583
134CDK60.14606474
135HCK0.14587178
136MST40.13670211
137DAPK30.13398602
138RPS6KA60.13166794
139RPS6KB10.12824097
140EGFR0.12044937
141PTK20.12011444
142PIK3CG0.11979018
143PRKCE0.11693690
144CAMK2A0.10784519
145CAMK2D0.10581823
146RET0.09968578
147TYK20.08937135
148RPS6KA10.08547204
149NEK60.08400004
150MST1R0.08217190
151SRC0.07689515
152EPHA30.07403598
153ERBB30.07306097
154ZAP700.06873070
155PRKCA0.05080136
156PIM20.03952707

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.79262824
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.66279486
3Fatty acid biosynthesis_Homo sapiens_hsa000612.32905825
4Notch signaling pathway_Homo sapiens_hsa043302.25620512
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.08118299
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.03852133
7Collecting duct acid secretion_Homo sapiens_hsa049661.95656908
8Mineral absorption_Homo sapiens_hsa049781.88189410
9Carbohydrate digestion and absorption_Homo sapiens_hsa049731.86470282
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.74881384
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70644294
12Glucagon signaling pathway_Homo sapiens_hsa049221.54340890
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51921469
14Chronic myeloid leukemia_Homo sapiens_hsa052201.49392371
15Other glycan degradation_Homo sapiens_hsa005111.48747808
16Bladder cancer_Homo sapiens_hsa052191.46788310
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42491188
18Hepatitis C_Homo sapiens_hsa051601.41764931
19Leishmaniasis_Homo sapiens_hsa051401.40793535
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39532573
21Insulin signaling pathway_Homo sapiens_hsa049101.39238029
22Renin-angiotensin system_Homo sapiens_hsa046141.36113918
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32385594
24Fructose and mannose metabolism_Homo sapiens_hsa000511.31364939
25Olfactory transduction_Homo sapiens_hsa047401.30021915
26Pentose phosphate pathway_Homo sapiens_hsa000301.30005769
27Renin secretion_Homo sapiens_hsa049241.29080844
28Amphetamine addiction_Homo sapiens_hsa050311.28094164
29mTOR signaling pathway_Homo sapiens_hsa041501.27108779
30Non-small cell lung cancer_Homo sapiens_hsa052231.26692871
31Sulfur relay system_Homo sapiens_hsa041221.25783472
32Phenylalanine metabolism_Homo sapiens_hsa003601.25120747
33Insulin resistance_Homo sapiens_hsa049311.23121653
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22616822
35Salmonella infection_Homo sapiens_hsa051321.18581742
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16984308
37Synaptic vesicle cycle_Homo sapiens_hsa047211.15497102
38Galactose metabolism_Homo sapiens_hsa000521.14809325
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14557781
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.13689126
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13550812
42GnRH signaling pathway_Homo sapiens_hsa049121.13427365
43Cardiac muscle contraction_Homo sapiens_hsa042601.11880104
44Legionellosis_Homo sapiens_hsa051341.11392833
45Long-term potentiation_Homo sapiens_hsa047201.11218646
46Glycerolipid metabolism_Homo sapiens_hsa005611.10731578
47Linoleic acid metabolism_Homo sapiens_hsa005911.09979436
48Endometrial cancer_Homo sapiens_hsa052131.08880064
49Pancreatic cancer_Homo sapiens_hsa052121.06128572
50Calcium signaling pathway_Homo sapiens_hsa040201.05511462
51Phagosome_Homo sapiens_hsa041451.04785638
52Basal transcription factors_Homo sapiens_hsa030221.03804621
53Rheumatoid arthritis_Homo sapiens_hsa053231.03462858
54AMPK signaling pathway_Homo sapiens_hsa041521.00010652
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99709543
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99041237
57Gastric acid secretion_Homo sapiens_hsa049710.97980127
58Shigellosis_Homo sapiens_hsa051310.97966778
59Toxoplasmosis_Homo sapiens_hsa051450.97084466
60Influenza A_Homo sapiens_hsa051640.96532151
61ErbB signaling pathway_Homo sapiens_hsa040120.96059050
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95330883
63Vibrio cholerae infection_Homo sapiens_hsa051100.93518607
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93506142
65Renal cell carcinoma_Homo sapiens_hsa052110.93222280
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.93068106
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93052258
68Pancreatic secretion_Homo sapiens_hsa049720.92382446
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.90731029
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.90315450
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89979294
72Choline metabolism in cancer_Homo sapiens_hsa052310.88466390
73HIF-1 signaling pathway_Homo sapiens_hsa040660.88332794
74Inositol phosphate metabolism_Homo sapiens_hsa005620.88325923
75Osteoclast differentiation_Homo sapiens_hsa043800.88003121
76Thyroid cancer_Homo sapiens_hsa052160.87729583
77Salivary secretion_Homo sapiens_hsa049700.87276485
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86278230
79Phototransduction_Homo sapiens_hsa047440.85656237
80Adherens junction_Homo sapiens_hsa045200.85586292
81Oocyte meiosis_Homo sapiens_hsa041140.84851781
82Sphingolipid metabolism_Homo sapiens_hsa006000.84150586
83Prolactin signaling pathway_Homo sapiens_hsa049170.83917554
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83520338
85Pyruvate metabolism_Homo sapiens_hsa006200.82690528
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82026535
87Estrogen signaling pathway_Homo sapiens_hsa049150.81807604
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.81631069
89Lysosome_Homo sapiens_hsa041420.81417356
90Dorso-ventral axis formation_Homo sapiens_hsa043200.80972491
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80713007
92Prion diseases_Homo sapiens_hsa050200.80026475
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.79555993
94Endocytosis_Homo sapiens_hsa041440.79292988
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78656729
96Arachidonic acid metabolism_Homo sapiens_hsa005900.78113099
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77800925
98VEGF signaling pathway_Homo sapiens_hsa043700.77447181
99Insulin secretion_Homo sapiens_hsa049110.76847279
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76763648
101Antigen processing and presentation_Homo sapiens_hsa046120.76259573
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75290870
103Tuberculosis_Homo sapiens_hsa051520.72423584
104Thyroid hormone synthesis_Homo sapiens_hsa049180.72409776
105Chemokine signaling pathway_Homo sapiens_hsa040620.69816172
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69664372
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.69231421
108T cell receptor signaling pathway_Homo sapiens_hsa046600.68596056
109Protein digestion and absorption_Homo sapiens_hsa049740.68476610
110Dilated cardiomyopathy_Homo sapiens_hsa054140.68204174
111ECM-receptor interaction_Homo sapiens_hsa045120.66896301
112Staphylococcus aureus infection_Homo sapiens_hsa051500.66677050
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66221738
114Amoebiasis_Homo sapiens_hsa051460.65645006
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.64865705
116Apoptosis_Homo sapiens_hsa042100.64042849
117cAMP signaling pathway_Homo sapiens_hsa040240.63453512
118Glioma_Homo sapiens_hsa052140.63142864
119Circadian entrainment_Homo sapiens_hsa047130.62791173
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62693598
121Focal adhesion_Homo sapiens_hsa045100.62207641
122Type II diabetes mellitus_Homo sapiens_hsa049300.61801421
123Platelet activation_Homo sapiens_hsa046110.61355432
124Oxytocin signaling pathway_Homo sapiens_hsa049210.59963312
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58554357
126Rap1 signaling pathway_Homo sapiens_hsa040150.57687596
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56971265
128Measles_Homo sapiens_hsa051620.56805079
129Melanoma_Homo sapiens_hsa052180.56177817
130Tight junction_Homo sapiens_hsa045300.55996759
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55901989
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53547657
133Viral myocarditis_Homo sapiens_hsa054160.53089617
134B cell receptor signaling pathway_Homo sapiens_hsa046620.53048434
135MAPK signaling pathway_Homo sapiens_hsa040100.52705275
136Hepatitis B_Homo sapiens_hsa051610.51591678
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51150683
138NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51068183
139Vitamin B6 metabolism_Homo sapiens_hsa007500.50637323
140PPAR signaling pathway_Homo sapiens_hsa033200.50628413
141Pertussis_Homo sapiens_hsa051330.50557099
142Malaria_Homo sapiens_hsa051440.50073970
143Proteoglycans in cancer_Homo sapiens_hsa052050.49581965
144TNF signaling pathway_Homo sapiens_hsa046680.49412123
145Fat digestion and absorption_Homo sapiens_hsa049750.49271363
146Acute myeloid leukemia_Homo sapiens_hsa052210.48363419
147Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47949692
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.47917449
149NF-kappa B signaling pathway_Homo sapiens_hsa040640.47586596
150Small cell lung cancer_Homo sapiens_hsa052220.46421822
151HTLV-I infection_Homo sapiens_hsa051660.46227697
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41885631

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