PXDN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon extension involved in axon guidance (GO:0048846)4.65451247
2neuron projection extension involved in neuron projection guidance (GO:1902284)4.65451247
3protein heterotrimerization (GO:0070208)4.64348117
4skin morphogenesis (GO:0043589)4.40697491
5collagen fibril organization (GO:0030199)4.13995432
6wound healing, spreading of epidermal cells (GO:0035313)4.05367596
7hippo signaling (GO:0035329)4.04250005
8paraxial mesoderm development (GO:0048339)3.98835155
9substrate-dependent cell migration (GO:0006929)3.95895656
10plasma membrane repair (GO:0001778)3.95400969
11polarized epithelial cell differentiation (GO:0030859)3.90876979
12chondrocyte proliferation (GO:0035988)3.89938980
13bone trabecula formation (GO:0060346)3.85352894
14basement membrane organization (GO:0071711)3.82922014
15insulin-like growth factor receptor signaling pathway (GO:0048009)3.81822294
16retina vasculature morphogenesis in camera-type eye (GO:0061299)3.68091870
17cardiac myofibril assembly (GO:0055003)3.67574095
18sequestering of extracellular ligand from receptor (GO:0035581)3.62254330
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.60392032
20glomerular filtration (GO:0003094)3.56929876
21renal filtration (GO:0097205)3.54668667
22hemidesmosome assembly (GO:0031581)3.53536005
23vascular endothelial growth factor signaling pathway (GO:0038084)3.52486499
24regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.44906180
25extracellular fibril organization (GO:0043206)3.39009634
26mesodermal cell differentiation (GO:0048333)3.38360332
27endodermal cell differentiation (GO:0035987)3.37859465
28heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.36304184
29regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.31626727
30glomerular basement membrane development (GO:0032836)3.30796196
31cell migration involved in sprouting angiogenesis (GO:0002042)3.30250074
32wound healing, spreading of cells (GO:0044319)3.29361177
33protein retention in ER lumen (GO:0006621)3.24563568
34cellular response to vitamin (GO:0071295)3.23075897
35endocardial cushion development (GO:0003197)3.22540426
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.19339606
37negative regulation of chondrocyte differentiation (GO:0032331)3.16498557
38Golgi transport vesicle coating (GO:0048200)3.13829632
39COPI coating of Golgi vesicle (GO:0048205)3.13829632
40positive regulation of blood vessel endothelial cell migration (GO:0043536)3.12793502
41type B pancreatic cell proliferation (GO:0044342)3.10779486
42embryonic foregut morphogenesis (GO:0048617)3.09577243
43heart morphogenesis (GO:0003007)3.07943482
44negative regulation of catenin import into nucleus (GO:0035414)3.07302727
45convergent extension (GO:0060026)3.05465674
46outer ear morphogenesis (GO:0042473)3.04972443
47sprouting angiogenesis (GO:0002040)3.04736729
48cell migration involved in heart development (GO:0060973)3.04226318
49vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.03746711
50extracellular matrix assembly (GO:0085029)3.03587512
51collagen metabolic process (GO:0032963)3.02593798
52regulation of cardioblast differentiation (GO:0051890)3.01803695
53adherens junction assembly (GO:0034333)2.98735480
54gastrulation with mouth forming second (GO:0001702)2.98242647
55negative regulation of axon extension involved in axon guidance (GO:0048843)2.95851688
56chondrocyte development (GO:0002063)2.94606433
57negative regulation of fatty acid transport (GO:2000192)2.93003889
58positive regulation of cartilage development (GO:0061036)2.92581604
59multicellular organismal macromolecule metabolic process (GO:0044259)2.92176864
60positive regulation of osteoblast proliferation (GO:0033690)2.91753735
61muscle cell migration (GO:0014812)2.90668098
62collagen catabolic process (GO:0030574)2.90575668
63establishment of apical/basal cell polarity (GO:0035089)2.90443202
64metanephric mesenchyme development (GO:0072075)2.89197119
65establishment of nucleus localization (GO:0040023)2.89067884
66negative regulation of smooth muscle cell migration (GO:0014912)2.87659346
67* extracellular matrix organization (GO:0030198)2.87449086
68epithelial cell-cell adhesion (GO:0090136)2.87185987
69cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.87043307
70branching involved in salivary gland morphogenesis (GO:0060445)2.86472714
71* extracellular structure organization (GO:0043062)2.86327312
72focal adhesion assembly (GO:0048041)2.85326527
73cell-substrate adherens junction assembly (GO:0007045)2.85326527
74positive regulation of endothelial cell apoptotic process (GO:2000353)2.85234574
75regulation of axon extension involved in axon guidance (GO:0048841)2.84556473
76negative regulation of cartilage development (GO:0061037)2.83586616
77lymphangiogenesis (GO:0001946)2.83230952
78heparan sulfate proteoglycan metabolic process (GO:0030201)2.82925792
79cochlea morphogenesis (GO:0090103)2.82667333
80dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.81950550
81stress fiber assembly (GO:0043149)2.80572074
82cytoskeletal anchoring at plasma membrane (GO:0007016)2.80522348
83endothelial cell morphogenesis (GO:0001886)2.80423576
84endothelium development (GO:0003158)2.80383085
85cellular response to vitamin D (GO:0071305)2.79838107
86fibril organization (GO:0097435)2.79655910
87trabecula formation (GO:0060343)2.78654916
88cell proliferation involved in metanephros development (GO:0072203)2.78654711
89regulation of chondrocyte differentiation (GO:0032330)2.78540774
90kidney mesenchyme development (GO:0072074)2.78306169
91cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.77619108
92G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.76870156
93atrioventricular valve morphogenesis (GO:0003181)2.75187429
94multicellular organismal metabolic process (GO:0044236)2.74613075
95craniofacial suture morphogenesis (GO:0097094)2.74339079
96blood vessel endothelial cell migration (GO:0043534)2.74210450
97positive regulation of glycogen biosynthetic process (GO:0045725)2.72619639
98cardiac muscle cell proliferation (GO:0060038)2.72518058
99atrial septum morphogenesis (GO:0060413)2.72084154
100mesenchyme development (GO:0060485)2.71521753
101extracellular matrix disassembly (GO:0022617)2.69460694
102positive regulation of epithelial to mesenchymal transition (GO:0010718)2.68610479
103cell-substrate junction assembly (GO:0007044)2.67962322
104axon extension (GO:0048675)2.66836520
105cell adhesion mediated by integrin (GO:0033627)2.66783147
106Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.66754130
107multicellular organismal catabolic process (GO:0044243)2.66456679
108myofibril assembly (GO:0030239)2.66279311
109camera-type eye morphogenesis (GO:0048593)2.65677055
110regulation of tight junction assembly (GO:2000810)2.64825127
111dermatan sulfate biosynthetic process (GO:0030208)2.62766372
112regulation of heart morphogenesis (GO:2000826)2.62636979
113lymph vessel development (GO:0001945)2.62563354
114semaphorin-plexin signaling pathway (GO:0071526)2.62290753
115substrate adhesion-dependent cell spreading (GO:0034446)2.61703499
116regulation of transforming growth factor beta2 production (GO:0032909)2.61500873
117regulation of establishment of planar polarity (GO:0090175)2.61399173
118positive regulation of mesenchymal cell proliferation (GO:0002053)2.60989391
119blood vessel maturation (GO:0001955)2.59677616
120mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.58705737
121venous blood vessel morphogenesis (GO:0048845)2.58554234
122tooth mineralization (GO:0034505)2.57678573
123protein localization to cell surface (GO:0034394)2.57651281
124regulation of axon guidance (GO:1902667)2.57288631
125lung-associated mesenchyme development (GO:0060484)2.56742865
126non-canonical Wnt signaling pathway (GO:0035567)2.56156805
127negative regulation of embryonic development (GO:0045992)2.54587089
128apoptotic cell clearance (GO:0043277)2.51943570
129negative regulation of axon guidance (GO:1902668)2.51656802
130mesenchymal-epithelial cell signaling (GO:0060638)2.51233716
131body morphogenesis (GO:0010171)2.51195412
132establishment or maintenance of monopolar cell polarity (GO:0061339)2.51045153
133establishment of monopolar cell polarity (GO:0061162)2.51045153
134regulation of cartilage development (GO:0061035)2.50912380
135heart trabecula formation (GO:0060347)2.49337783
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.48066085
137regulation of mesenchymal cell proliferation (GO:0010464)2.47711885
138regulation of hippo signaling (GO:0035330)2.46881286
139artery development (GO:0060840)2.46547266
140proximal/distal pattern formation (GO:0009954)2.46424038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.87347411
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.15608570
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.06711669
4CLOCK_20551151_ChIP-Seq_293T_Human3.03813668
5EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.80767699
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60374988
7WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.53514271
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.53005137
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.39537364
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.28678629
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15219468
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13965231
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13965231
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13697280
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.03668080
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.03646186
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.01238658
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93946273
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.88797259
20* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88530354
21DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.85607679
22* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83978634
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83445908
24* ISL1_27105846_Chip-Seq_CPCs_Mouse1.83370023
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.82187851
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79462396
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73783535
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.73591268
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72887058
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72755322
31* TP53_22127205_ChIP-Seq_IMR90_Human1.70880470
32TP53_20018659_ChIP-ChIP_R1E_Mouse1.66228853
33* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64548476
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62127860
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61496200
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61207080
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.60765390
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.58826994
39BRD4_25478319_ChIP-Seq_HGPS_Human1.58764823
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56142336
41CJUN_26792858_Chip-Seq_BT549_Human1.55473458
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.54657787
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54573376
44* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53418087
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.49233041
46KDM2B_26808549_Chip-Seq_K562_Human1.48558254
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.47064384
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46854721
49* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45613725
50* TBX20_22328084_ChIP-Seq_HEART_Mouse1.45586409
51* TBX20_22080862_ChIP-Seq_HEART_Mouse1.45586409
52* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45525750
53* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45233813
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45103980
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.43949699
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.43140061
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42269350
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41643409
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.39481824
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39428297
61* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38881980
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38196597
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37894027
64ZNF263_19887448_ChIP-Seq_K562_Human1.36553848
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36409569
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34790350
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34774225
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33996809
69SA1_22415368_ChIP-Seq_MEFs_Mouse1.32754685
70SMC3_22415368_ChIP-Seq_MEFs_Mouse1.31403876
71* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31040712
72SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30407216
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.28324674
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27915408
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27188706
76EZH2_22144423_ChIP-Seq_EOC_Human1.25951209
77TP53_16413492_ChIP-PET_HCT116_Human1.25718333
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.25176686
79* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24086991
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23609071
81* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23439647
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22938183
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22253726
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22238571
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22238571
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22178928
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.20396189
88FOXM1_23109430_ChIP-Seq_U2OS_Human1.19775843
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18531972
90MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18129319
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17914446
92* RING1B_27294783_Chip-Seq_ESCs_Mouse1.17816576
93KDM2B_26808549_Chip-Seq_DND41_Human1.17631371
94* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14487276
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14157759
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14110563
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.13939334
98* KDM2B_26808549_Chip-Seq_JURKAT_Human1.13926704
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12952836
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.11249582
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10772419
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08988619
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08061394
104TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06735739
105* DROSHA_22980978_ChIP-Seq_HELA_Human1.05062758
106EZH2_27294783_Chip-Seq_ESCs_Mouse1.04730223
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04195249
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04195249
109AHR_22903824_ChIP-Seq_MCF-7_Human1.03962398
110TP53_18474530_ChIP-ChIP_U2OS_Human1.03847649
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03658856
112RACK7_27058665_Chip-Seq_MCF-7_Human1.02666410
113TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02455570
114TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01942472
115* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01229461
116* TP53_23651856_ChIP-Seq_MEFs_Mouse1.01157726
117TET1_21490601_ChIP-Seq_MESCs_Mouse1.00307815
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00085966
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99987294
120SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99657110
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99077786
122EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97584343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.40821692
2MP0004272_abnormal_basement_membrane3.94969298
3MP0003705_abnormal_hypodermis_morpholog3.58090269
4MP0005275_abnormal_skin_tensile3.36695363
5MP0005503_abnormal_tendon_morphology3.05637174
6MP0005623_abnormal_meninges_morphology2.97479904
7MP0010030_abnormal_orbit_morphology2.58642978
8MP0003279_aneurysm2.54192455
9MP0010368_abnormal_lymphatic_system2.41918283
10MP0003122_maternal_imprinting2.27893707
11MP0003385_abnormal_body_wall2.24914885
12MP0009053_abnormal_anal_canal2.18414973
13MP0000537_abnormal_urethra_morphology2.15478708
14MP0004084_abnormal_cardiac_muscle2.05187564
15MP0001958_emphysema2.03394199
16MP0000751_myopathy1.99260340
17MP0006054_spinal_hemorrhage1.92201519
18MP0003123_paternal_imprinting1.88368107
19MP0001542_abnormal_bone_strength1.72454287
20MP0000733_abnormal_muscle_development1.69562100
21MP0003942_abnormal_urinary_system1.65853978
22MP0003566_abnormal_cell_adhesion1.61723220
23MP0000534_abnormal_ureter_morphology1.61318150
24MP0001879_abnormal_lymphatic_vessel1.60164906
25MP0003115_abnormal_respiratory_system1.59546952
26MP0009384_cardiac_valve_regurgitation1.59529433
27MP0006138_congestive_heart_failure1.58773768
28MP0009250_abnormal_appendicular_skeleto1.57660107
29MP0003950_abnormal_plasma_membrane1.56202322
30MP0005508_abnormal_skeleton_morphology1.50522606
31MP0003283_abnormal_digestive_organ1.47119755
32MP0004233_abnormal_muscle_weight1.43210837
33MP0002108_abnormal_muscle_morphology1.42284321
34MP0000428_abnormal_craniofacial_morphol1.42166311
35MP0003941_abnormal_skin_development1.41303345
36MP0002932_abnormal_joint_morphology1.39769746
37MP0000762_abnormal_tongue_morphology1.38058706
38MP0003567_abnormal_fetal_cardiomyocyte1.35485039
39MP0000013_abnormal_adipose_tissue1.35257732
40MP0000767_abnormal_smooth_muscle1.33171107
41MP0002282_abnormal_trachea_morphology1.33066311
42MP0002837_dystrophic_cardiac_calcinosis1.31712521
43MP0003121_genomic_imprinting1.30499254
44MP0000750_abnormal_muscle_regeneration1.29777385
45MP0003935_abnormal_craniofacial_develop1.29646771
46MP0003091_abnormal_cell_migration1.29237438
47MP0003937_abnormal_limbs/digits/tail_de1.27993115
48MP0004087_abnormal_muscle_fiber1.27954001
49MP0002249_abnormal_larynx_morphology1.26580155
50MP0005595_abnormal_vascular_smooth1.25634247
51MP0005076_abnormal_cell_differentiation1.25134856
52MP0001299_abnormal_eye_distance/1.24504310
53MP0002877_abnormal_melanocyte_morpholog1.24106326
54MP0002896_abnormal_bone_mineralization1.23762186
55MP0010630_abnormal_cardiac_muscle1.23520702
56MP0000049_abnormal_middle_ear1.23252441
57MP0010352_gastrointestinal_tract_polyps1.20294897
58MP0001243_abnormal_dermal_layer1.19117686
59MP0000003_abnormal_adipose_tissue1.19106124
60MP0004215_abnormal_myocardial_fiber1.16190664
61MP0003755_abnormal_palate_morphology1.15617158
62MP0002925_abnormal_cardiovascular_devel1.13335242
63MP0005197_abnormal_uvea_morphology1.12044848
64MP0002697_abnormal_eye_size1.08521935
65MP0003119_abnormal_digestive_system1.08049395
66MP0000462_abnormal_digestive_system1.07791356
67MP0005330_cardiomyopathy1.06888874
68MP0002060_abnormal_skin_morphology1.04935953
69MP0004036_abnormal_muscle_relaxation1.04740722
70MP0009780_abnormal_chondrocyte_physiolo1.04046601
71MP0005385_cardiovascular_system_phenoty1.03079086
72MP0001544_abnormal_cardiovascular_syste1.03079086
73MP0002234_abnormal_pharynx_morphology1.00954914
74MP0005187_abnormal_penis_morphology1.00438330
75MP0004197_abnormal_fetal_growth/weight/1.00249125
76MP0002972_abnormal_cardiac_muscle0.99579384
77MP0005375_adipose_tissue_phenotype0.99363309
78MP0001915_intracranial_hemorrhage0.98680028
79MP0002128_abnormal_blood_circulation0.98515596
80MP0008775_abnormal_heart_ventricle0.98515105
81MP0001614_abnormal_blood_vessel0.97247308
82MP0005620_abnormal_muscle_contractility0.96835838
83MP0001849_ear_inflammation0.96779899
84MP0005248_abnormal_Harderian_gland0.96429556
85MP0000759_abnormal_skeletal_muscle0.96076773
86MP0002116_abnormal_craniofacial_bone0.95536225
87MP0004145_abnormal_muscle_electrophysio0.95472102
88MP0003828_pulmonary_edema0.95363700
89MP0002295_abnormal_pulmonary_circulatio0.94965650
90MP0000163_abnormal_cartilage_morphology0.94078997
91MP0000266_abnormal_heart_morphology0.94006300
92MP0004858_abnormal_nervous_system0.93085807
93MP0002254_reproductive_system_inflammat0.92552633
94MP0005666_abnormal_adipose_tissue0.92323444
95MP0005670_abnormal_white_adipose0.92262500
96MP0001348_abnormal_lacrimal_gland0.91193564
97MP0002233_abnormal_nose_morphology0.90616358
98MP0004130_abnormal_muscle_cell0.90456765
99MP0010234_abnormal_vibrissa_follicle0.89478302
100MP0004185_abnormal_adipocyte_glucose0.89103530
101MP0005023_abnormal_wound_healing0.87726980
102MP0000432_abnormal_head_morphology0.86218210
103MP0002115_abnormal_skeleton_extremities0.85798814
104MP0004134_abnormal_chest_morphology0.84336795
105MP0005369_muscle_phenotype0.84044571
106MP0005257_abnormal_intraocular_pressure0.83958646
107MP0002111_abnormal_tail_morphology0.82996278
108MP0002109_abnormal_limb_morphology0.82116882
109MP0003045_fibrosis0.81914037
110MP0002084_abnormal_developmental_patter0.81481702
111MP0005409_darkened_coat_color0.79357359
112MP0005367_renal/urinary_system_phenotyp0.79208743
113MP0000516_abnormal_urinary_system0.79208743
114MP0002092_abnormal_eye_morphology0.79033303
115MP0005390_skeleton_phenotype0.76469818
116MP0002114_abnormal_axial_skeleton0.75001784
117MP0000749_muscle_degeneration0.74742073
118MP0005193_abnormal_anterior_eye0.74252231
119MP0000467_abnormal_esophagus_morphology0.74023677
120MP0002113_abnormal_skeleton_development0.71850159
121MP0002085_abnormal_embryonic_tissue0.68235515
122MP0002089_abnormal_postnatal_growth/wei0.64339530
123MP0001175_abnormal_lung_morphology0.64176459
124MP0002177_abnormal_outer_ear0.63840000
125MP0003448_altered_tumor_morphology0.60605605
126MP0001286_abnormal_eye_development0.60000203
127MP0005171_absent_coat_pigmentation0.59381508
128MP0002133_abnormal_respiratory_system0.58233786
129MP0005388_respiratory_system_phenotype0.58233786
130MP0000579_abnormal_nail_morphology0.57737802

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.85081188
2Premature rupture of membranes (HP:0001788)5.06146509
3Shallow orbits (HP:0000586)4.74322322
4Ankle contracture (HP:0006466)4.34918536
5Broad metatarsal (HP:0001783)4.20149148
6Cerebral aneurysm (HP:0004944)3.97237590
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.96408728
8Short 4th metacarpal (HP:0010044)3.96408728
9Aortic dissection (HP:0002647)3.68284862
10Abnormality of the 4th metacarpal (HP:0010012)3.58049561
11Bladder diverticulum (HP:0000015)3.35330460
12Type 1 muscle fiber predominance (HP:0003803)3.16266388
13Atrophic scars (HP:0001075)3.15849804
14Increased connective tissue (HP:0009025)3.07803339
15Aortic aneurysm (HP:0004942)3.07335492
16Mitral valve prolapse (HP:0001634)3.06628840
17Dilatation of the ascending aorta (HP:0005111)2.94582864
18Soft skin (HP:0000977)2.91591232
19Wrist flexion contracture (HP:0001239)2.86743687
20Spinal rigidity (HP:0003306)2.81531980
21Fragile skin (HP:0001030)2.69645343
22Renal duplication (HP:0000075)2.65384267
23Abnormality of dentin (HP:0010299)2.63696450
24Spondylolisthesis (HP:0003302)2.62379065
25Vertebral compression fractures (HP:0002953)2.59473717
26Lymphangioma (HP:0100764)2.57145010
27Follicular hyperkeratosis (HP:0007502)2.54544915
28Increased variability in muscle fiber diameter (HP:0003557)2.52494658
29Biconcave vertebral bodies (HP:0004586)2.50315212
30Mildly elevated creatine phosphokinase (HP:0008180)2.45487195
31Bowel diverticulosis (HP:0005222)2.42412015
32Asymmetry of the thorax (HP:0001555)2.40827646
33Aneurysm (HP:0002617)2.37279287
34Genu recurvatum (HP:0002816)2.35291028
35Abnormal delivery (HP:0001787)2.32424981
36Deviation of the hallux (HP:0010051)2.31352713
37Peritonitis (HP:0002586)2.30279260
38Overgrowth (HP:0001548)2.30158656
39Short nail (HP:0001799)2.29782638
40Blue sclerae (HP:0000592)2.29611922
41Cervical subluxation (HP:0003308)2.28609238
42Wormian bones (HP:0002645)2.28574328
43Aortic regurgitation (HP:0001659)2.28059681
44Neonatal short-limb short stature (HP:0008921)2.26251050
45Abnormality of the acetabulum (HP:0003170)2.23646746
46Muscle fiber splitting (HP:0003555)2.22344347
47Wide anterior fontanel (HP:0000260)2.20695564
48Hallux valgus (HP:0001822)2.15580797
49Abnormality of skeletal muscle fiber size (HP:0012084)2.12722733
50Mesomelia (HP:0003027)2.11721889
51Joint laxity (HP:0001388)2.11171058
52Round ear (HP:0100830)2.11016915
53Camptodactyly of toe (HP:0001836)2.09665297
54Broad ribs (HP:0000885)2.08405666
55Vascular tortuosity (HP:0004948)2.07221871
56Aortic valve stenosis (HP:0001650)2.05594931
57Thin bony cortex (HP:0002753)2.05212406
58Scapular winging (HP:0003691)2.04881680
59Osteolytic defects of the hand bones (HP:0009699)2.04604987
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.04604987
61Hyperextensible skin (HP:0000974)2.03309339
62Slender build (HP:0001533)2.01680503
63Flat cornea (HP:0007720)2.01513548
64Nonimmune hydrops fetalis (HP:0001790)2.00958832
65Natal tooth (HP:0000695)1.99223728
66Broad long bones (HP:0005622)1.98179205
67Enlarged penis (HP:0000040)1.97719692
68Arterial tortuosity (HP:0005116)1.97406381
69Inguinal hernia (HP:0000023)1.94752784
70Right ventricular cardiomyopathy (HP:0011663)1.94739136
71Striae distensae (HP:0001065)1.94150123
72Coronal craniosynostosis (HP:0004440)1.93270542
73Hip contracture (HP:0003273)1.92535457
74Broad toe (HP:0001837)1.91309757
75Renovascular hypertension (HP:0100817)1.89353086
76Hyperacusis (HP:0010780)1.88597059
77Infantile muscular hypotonia (HP:0008947)1.88385344
78Breech presentation (HP:0001623)1.87307530
79Broad thumb (HP:0011304)1.87156153
80Mitral regurgitation (HP:0001653)1.86886384
81Long toe (HP:0010511)1.86583528
82Joint stiffness (HP:0001387)1.85713440
83Short hallux (HP:0010109)1.84334924
84Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82192683
85Difficulty climbing stairs (HP:0003551)1.82004558
86Rectal prolapse (HP:0002035)1.81221135
87Sudden death (HP:0001699)1.81148959
88Arachnodactyly (HP:0001166)1.80894661
89Disproportionate tall stature (HP:0001519)1.80150292
90Absent frontal sinuses (HP:0002688)1.79928267
91Difficulty running (HP:0009046)1.79749822
92Subacute progressive viral hepatitis (HP:0006572)1.79570783
93Elbow flexion contracture (HP:0002987)1.78929578
94Broad phalanx (HP:0006009)1.78631974
95Limited hip movement (HP:0008800)1.78598479
96Venous abnormality (HP:0002624)1.78372211
97Venous insufficiency (HP:0005293)1.78190888
98Upper limb amyotrophy (HP:0009129)1.77515699
99Distal upper limb amyotrophy (HP:0007149)1.77515699
100Premature skin wrinkling (HP:0100678)1.76723356
101Bowed forearm bones (HP:0003956)1.76482289
102Bowing of the arm (HP:0006488)1.76482289
103Hepatoblastoma (HP:0002884)1.76145991
104Bronchomalacia (HP:0002780)1.75939057
105Abnormality of the distal phalanx of the thumb (HP:0009617)1.75918421
106Generalized amyotrophy (HP:0003700)1.75073974
107Syringomyelia (HP:0003396)1.74405846
108Mild short stature (HP:0003502)1.74366570
109Broad finger (HP:0001500)1.73347240
110Abnormality of the calcaneus (HP:0008364)1.72955616
111Ulnar bowing (HP:0003031)1.72910813
112Broad phalanges of the hand (HP:0009768)1.72596657
113Thoracolumbar scoliosis (HP:0002944)1.72217321
114Delayed cranial suture closure (HP:0000270)1.70699644
115Morphological abnormality of the middle ear (HP:0008609)1.69600524
116Ectopia lentis (HP:0001083)1.69220121
117Protruding ear (HP:0000411)1.69038477
118Knee flexion contracture (HP:0006380)1.67752564
119Limb-girdle muscle weakness (HP:0003325)1.67632123
120Mitral stenosis (HP:0001718)1.67244054
121Aplasia/Hypoplasia of the hallux (HP:0008362)1.67188181
122Turricephaly (HP:0000262)1.66584743
123Thin ribs (HP:0000883)1.66289016
124Broad face (HP:0000283)1.66220504
125Abnormality of the calf musculature (HP:0001430)1.65858654
126Increased density of long bones (HP:0006392)1.65727630
127Hydroureter (HP:0000072)1.65508856
128Hyporeflexia of lower limbs (HP:0002600)1.64208705
129Hypoplastic ischia (HP:0003175)1.63611545
130Lipoatrophy (HP:0100578)1.63209911
131Joint contractures involving the joints of the feet (HP:0100492)1.62886559
132Flexion contracture of toe (HP:0005830)1.62886559
133Hypoventilation (HP:0002791)1.62157333
134Elfin facies (HP:0004428)1.61948370
135Broad hallux (HP:0010055)1.61921161
136Spinal cord lesions (HP:0100561)1.61870289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.12368397
2TTN3.76848439
3LATS13.39885330
4PDGFRA3.39859510
5DDR22.99654719
6PKN22.98504871
7TIE12.76682322
8EPHB22.74935540
9LATS22.68600404
10RIPK12.64880287
11SIK12.22727670
12FLT31.85103949
13DMPK1.80572405
14FER1.74742245
15PTK61.73553489
16MAP3K101.69939086
17PRKD31.64818204
18PAK21.58878608
19KDR1.55462926
20PTK21.55147680
21CAMK1D1.52891057
22FGFR11.49921138
23CAMK1G1.49005499
24PAK41.47539640
25FGFR21.43168267
26PTK2B1.35520453
27TGFBR11.34465510
28LMTK21.33878032
29ERBB41.31331567
30SMG11.30451977
31TGFBR21.27710778
32MTOR1.24173644
33EEF2K1.23671148
34BMX1.22838588
35PDGFRB1.22645591
36PAK31.22556473
37MYLK1.14379836
38STK31.10829245
39ILK1.10113516
40TYRO31.08630384
41MET1.05208445
42ICK1.03591080
43CDK121.03256604
44STK38L1.01136718
45ROCK11.00785087
46PIK3CG0.97643711
47KSR10.92962632
48NEK10.91234308
49PRKG20.89972173
50LRRK20.88428688
51PAK60.87974428
52CDC42BPA0.87665125
53RET0.86865737
54EPHA30.75612087
55ERBB30.73544189
56PIM20.72255595
57PRKD10.71211935
58CDK80.70983893
59MAP3K60.69915234
60ERBB20.68647497
61KSR20.68636187
62ABL20.67358295
63CDK60.67229895
64ROCK20.66901155
65AKT30.66639893
66SCYL20.66366247
67NTRK10.66283275
68LIMK10.65612969
69PIK3CA0.65367764
70ARAF0.62624925
71ERN10.61866019
72DYRK1B0.61507982
73MAP2K10.60608150
74STK380.59525432
75PRKCH0.59019291
76GSK3A0.58972517
77ADRBK10.58955979
78MAPK70.55048026
79FGFR40.53460884
80PHKG20.53205344
81PHKG10.53205344
82CLK10.51335233
83FGFR30.49463885
84PLK20.47768431
85RPS6KL10.47571856
86RPS6KC10.47571856
87PNCK0.47153247
88SRC0.47106022
89MAP3K70.44210725
90AKT20.42194443
91TRPM70.41567957
92MARK10.40893600
93PRKD20.40761534
94INSR0.40591377
95BRD40.38738907
96OBSCN0.38644923
97EPHA20.37736362
98MARK20.37606526
99RPS6KA20.37081949
100CDK150.36436349
101CDK11A0.36366327
102MKNK10.35952280
103ALK0.35951977
104CAMK40.35478232
105MAP3K80.33977013
106CDK70.33791035
107WNK10.33487066
108EPHB10.33462161
109NEK20.33055333
110CDK180.32792202
111PDK40.32514837
112PDK30.32514837
113NEK90.31348561
114TESK10.31204059
115MST1R0.31150344
116EPHA40.31089723
117RPS6KA60.30068790
118TAF10.29445947
119CDK140.29227265
120MELK0.29055235
121DAPK30.28591695
122MOS0.28561382
123CSNK1A1L0.28476282
124CAMKK10.28048620
125GRK50.27740364
126PAK10.27605253
127BRAF0.27346747
128CDK90.27161909
129PRKCE0.26079084
130IGF1R0.26071695

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.54672677
2Focal adhesion_Homo sapiens_hsa045102.73114947
3Dilated cardiomyopathy_Homo sapiens_hsa054142.48867979
4Basal cell carcinoma_Homo sapiens_hsa052172.39041598
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.37460032
6Adherens junction_Homo sapiens_hsa045202.33236817
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.26365661
8Hippo signaling pathway_Homo sapiens_hsa043902.14343899
9Proteoglycans in cancer_Homo sapiens_hsa052052.11514968
10Hedgehog signaling pathway_Homo sapiens_hsa043402.02698476
11Small cell lung cancer_Homo sapiens_hsa052221.90853471
12Protein digestion and absorption_Homo sapiens_hsa049741.86027973
13Amoebiasis_Homo sapiens_hsa051461.82366804
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.74633097
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.72808175
16Axon guidance_Homo sapiens_hsa043601.67621607
17TGF-beta signaling pathway_Homo sapiens_hsa043501.67331888
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.61417065
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60622093
20Tight junction_Homo sapiens_hsa045301.56989003
21MicroRNAs in cancer_Homo sapiens_hsa052061.56180326
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45096558
23Viral myocarditis_Homo sapiens_hsa054161.44430923
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40358694
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.38820414
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33436888
27Melanogenesis_Homo sapiens_hsa049161.32679634
28Bladder cancer_Homo sapiens_hsa052191.32253924
29Notch signaling pathway_Homo sapiens_hsa043301.29069736
30Chronic myeloid leukemia_Homo sapiens_hsa052201.27785686
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.27198164
32Wnt signaling pathway_Homo sapiens_hsa043101.26870426
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26430082
34Glioma_Homo sapiens_hsa052141.23260752
35Rap1 signaling pathway_Homo sapiens_hsa040151.20786977
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.18990970
37Pathways in cancer_Homo sapiens_hsa052001.17856848
38Gap junction_Homo sapiens_hsa045401.11946564
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11073439
40Endometrial cancer_Homo sapiens_hsa052131.09579527
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06640889
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05514537
43Estrogen signaling pathway_Homo sapiens_hsa049151.05439315
44mTOR signaling pathway_Homo sapiens_hsa041501.05180322
45Colorectal cancer_Homo sapiens_hsa052101.05097517
46Melanoma_Homo sapiens_hsa052181.04248864
47AMPK signaling pathway_Homo sapiens_hsa041521.02556921
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.02357636
49Lysine degradation_Homo sapiens_hsa003101.01373232
50Renal cell carcinoma_Homo sapiens_hsa052111.01195278
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00731829
52N-Glycan biosynthesis_Homo sapiens_hsa005100.98885302
53Prion diseases_Homo sapiens_hsa050200.98760455
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98687092
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95784940
56Insulin resistance_Homo sapiens_hsa049310.95173489
57Dorso-ventral axis formation_Homo sapiens_hsa043200.93986173
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92123801
59Renin secretion_Homo sapiens_hsa049240.91283107
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91079718
61p53 signaling pathway_Homo sapiens_hsa041150.90273151
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88450189
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86641838
64Prostate cancer_Homo sapiens_hsa052150.86367622
65Insulin signaling pathway_Homo sapiens_hsa049100.86301297
66Pancreatic cancer_Homo sapiens_hsa052120.86202483
67Oxytocin signaling pathway_Homo sapiens_hsa049210.84837192
68HTLV-I infection_Homo sapiens_hsa051660.83241072
69Fatty acid biosynthesis_Homo sapiens_hsa000610.82197776
70GnRH signaling pathway_Homo sapiens_hsa049120.82115412
71Platelet activation_Homo sapiens_hsa046110.81947360
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80949572
73VEGF signaling pathway_Homo sapiens_hsa043700.80887595
74HIF-1 signaling pathway_Homo sapiens_hsa040660.80160030
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79994238
76Glucagon signaling pathway_Homo sapiens_hsa049220.79873659
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.78660816
78Shigellosis_Homo sapiens_hsa051310.78498082
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75000994
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.73475677
81Vibrio cholerae infection_Homo sapiens_hsa051100.72888739
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71739142
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.70178923
84Oocyte meiosis_Homo sapiens_hsa041140.69921967
85Thyroid cancer_Homo sapiens_hsa052160.69190337
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68742894
87cAMP signaling pathway_Homo sapiens_hsa040240.68626609
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.67771530
89Toxoplasmosis_Homo sapiens_hsa051450.67663798
90Malaria_Homo sapiens_hsa051440.66279214
91Non-small cell lung cancer_Homo sapiens_hsa052230.65539242
92Ovarian steroidogenesis_Homo sapiens_hsa049130.63966284
93PPAR signaling pathway_Homo sapiens_hsa033200.62994827
94Type II diabetes mellitus_Homo sapiens_hsa049300.62427702
95ErbB signaling pathway_Homo sapiens_hsa040120.62411769
96Circadian entrainment_Homo sapiens_hsa047130.61359385
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59846172
98Ras signaling pathway_Homo sapiens_hsa040140.59159795
99Gastric acid secretion_Homo sapiens_hsa049710.58544284
100Thyroid hormone synthesis_Homo sapiens_hsa049180.56053866
101Fatty acid metabolism_Homo sapiens_hsa012120.52704673
102Other glycan degradation_Homo sapiens_hsa005110.52283437
103FoxO signaling pathway_Homo sapiens_hsa040680.51975701
104Cocaine addiction_Homo sapiens_hsa050300.51511377
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51475241
106Cholinergic synapse_Homo sapiens_hsa047250.50774239
107MAPK signaling pathway_Homo sapiens_hsa040100.50756503
108Cardiac muscle contraction_Homo sapiens_hsa042600.50468479
109Endocytosis_Homo sapiens_hsa041440.47479981
110Galactose metabolism_Homo sapiens_hsa000520.46653733
111Salmonella infection_Homo sapiens_hsa051320.43770061
112Cell cycle_Homo sapiens_hsa041100.43225018
113Dopaminergic synapse_Homo sapiens_hsa047280.43125527
114Salivary secretion_Homo sapiens_hsa049700.41882894
115Choline metabolism in cancer_Homo sapiens_hsa052310.35177939
116Pentose phosphate pathway_Homo sapiens_hsa000300.34642648
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31264168
118Biosynthesis of amino acids_Homo sapiens_hsa012300.30625049
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29753878
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.29214139
121Prolactin signaling pathway_Homo sapiens_hsa049170.29095570
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26482209
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25601602

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