PXDNL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.33932460
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.95677206
3cardiac myofibril assembly (GO:0055003)6.54346055
4regulation of actin filament-based movement (GO:1903115)6.49872925
5actin-myosin filament sliding (GO:0033275)6.26404541
6muscle filament sliding (GO:0030049)6.26404541
7cardiac muscle contraction (GO:0060048)6.25953264
8regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.20846583
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.19148041
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.00982735
11ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.89755364
12cardiac muscle hypertrophy (GO:0003300)5.70397512
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.69182923
14myofibril assembly (GO:0030239)5.67537084
15cardiac muscle tissue morphogenesis (GO:0055008)5.60545659
16negative regulation of potassium ion transmembrane transport (GO:1901380)5.55380586
17striated muscle hypertrophy (GO:0014897)5.38438349
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.36652841
19actin-mediated cell contraction (GO:0070252)5.27181717
20regulation of relaxation of muscle (GO:1901077)5.25321959
21cell communication by electrical coupling (GO:0010644)5.12741465
22regulation of cell communication by electrical coupling (GO:0010649)5.12420078
23cell communication involved in cardiac conduction (GO:0086065)5.01146314
24muscle tissue morphogenesis (GO:0060415)4.96081404
25actomyosin structure organization (GO:0031032)4.91644277
26regulation of cardiac muscle cell contraction (GO:0086004)4.89110484
27adult heart development (GO:0007512)4.84107354
28ventricular cardiac muscle cell action potential (GO:0086005)4.79193016
29cardiac cell development (GO:0055006)4.76382015
30cardiac muscle cell development (GO:0055013)4.71486307
31muscle hypertrophy (GO:0014896)4.70602666
32heart process (GO:0003015)4.62288427
33heart contraction (GO:0060047)4.62288427
34regulation of the force of heart contraction (GO:0002026)4.54516501
35regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.50259088
36striated muscle contraction (GO:0006941)4.47453697
37sarcoplasmic reticulum calcium ion transport (GO:0070296)4.46248085
38regulation of membrane repolarization (GO:0060306)4.44523778
39positive regulation of vascular permeability (GO:0043117)4.41597248
40detection of calcium ion (GO:0005513)4.39870034
41regulation of striated muscle contraction (GO:0006942)4.30067748
42regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.25483379
43cardiac muscle adaptation (GO:0014887)4.13927659
44cardiac muscle hypertrophy in response to stress (GO:0014898)4.13927659
45muscle hypertrophy in response to stress (GO:0003299)4.13927659
46bundle of His cell to Purkinje myocyte communication (GO:0086069)4.09737544
47actin filament-based movement (GO:0030048)4.03475427
48response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.99527775
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98758878
50regulation of heart rate (GO:0002027)3.95774128
51neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.90714139
52regulation of cardiac muscle contraction (GO:0055117)3.86831705
53cardiac chamber formation (GO:0003207)3.86002669
54cellular response to epinephrine stimulus (GO:0071872)3.85829644
55regulation of cardioblast differentiation (GO:0051890)3.82582536
56regulation of sarcomere organization (GO:0060297)3.81492866
57positive regulation of heart rate (GO:0010460)3.80140253
58positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.71458621
59cardiac ventricle formation (GO:0003211)3.69224982
60heart trabecula formation (GO:0060347)3.65886113
61response to epinephrine (GO:0071871)3.65820065
62cardiac muscle cell action potential (GO:0086001)3.60653340
63coronary vasculature morphogenesis (GO:0060977)3.60293927
64cardiac muscle cell action potential involved in contraction (GO:0086002)3.52857014
65calcium-mediated signaling using intracellular calcium source (GO:0035584)3.48736627
66regulation of ATPase activity (GO:0043462)3.44918617
67regulation of ATP catabolic process (GO:1903289)3.44918617
68ventricular cardiac muscle cell development (GO:0055015)3.41754306
69regulation of heart contraction (GO:0008016)3.41346722
70cellular response to catecholamine stimulus (GO:0071870)3.36916726
71cellular response to monoamine stimulus (GO:0071868)3.36916726
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32054581
73positive regulation of action potential (GO:0045760)3.27829583
74protein heterotrimerization (GO:0070208)3.25095513
75negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.23056451
76positive regulation of heart growth (GO:0060421)3.22608765
77regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19827497
78atrioventricular valve morphogenesis (GO:0003181)3.15663735
79response to monoamine (GO:0071867)3.13313909
80response to catecholamine (GO:0071869)3.13313909
81cardiac conduction (GO:0061337)3.12146331
82negative regulation of protein localization to cell surface (GO:2000009)3.08863089
83positive regulation of heart contraction (GO:0045823)3.07525984
84response to inactivity (GO:0014854)3.06297595
85heart valve formation (GO:0003188)3.04806997
86regulation of vascular permeability (GO:0043114)2.98962906
87adrenergic receptor signaling pathway (GO:0071875)2.97790308
88adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.97511696
89negative regulation of potassium ion transport (GO:0043267)2.96622669
90venous blood vessel morphogenesis (GO:0048845)2.96301973
91regulation of calcium ion transmembrane transporter activity (GO:1901019)2.92813442
92regulation of calcium ion transmembrane transport (GO:1903169)2.92813442
93suckling behavior (GO:0001967)2.92805605
94ventricular trabecula myocardium morphogenesis (GO:0003222)2.91374930
95relaxation of cardiac muscle (GO:0055119)2.90951231
96muscle contraction (GO:0006936)2.89993387
97carnitine shuttle (GO:0006853)2.88153944
98ionotropic glutamate receptor signaling pathway (GO:0035235)2.88136110
99regulation of muscle contraction (GO:0006937)2.86073490
100Notch signaling involved in heart development (GO:0061314)2.85358507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.62733443
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.99927627
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.38981774
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.31109996
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.62426889
6GBX2_23144817_ChIP-Seq_PC3_Human2.60517476
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.53098923
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41825493
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.37451093
10MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.05633381
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00897913
12* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00382030
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99533992
14TAF15_26573619_Chip-Seq_HEK293_Human1.99007720
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.98492794
16TBX20_22080862_ChIP-Seq_HEART_Mouse1.82981195
17TBX20_22328084_ChIP-Seq_HEART_Mouse1.82981195
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79199579
19WT1_19549856_ChIP-ChIP_CCG9911_Human1.72918426
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.64595258
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.63918624
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61568792
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61568792
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59521523
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59255566
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.59155094
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51709084
28VDR_22108803_ChIP-Seq_LS180_Human1.49431754
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48280912
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48210467
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.46787101
32YAP1_20516196_ChIP-Seq_MESCs_Mouse1.45462801
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44510550
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.42677036
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41094002
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.40721250
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39557158
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.39335284
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38316880
40TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36874427
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36475450
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35374984
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35365837
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29888457
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.29662621
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29350957
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28769521
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28682480
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28682480
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28228749
51SMAD4_21741376_ChIP-Seq_HESCs_Human1.24862187
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24270394
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23993593
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.23863309
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21779140
56TP53_16413492_ChIP-PET_HCT116_Human1.21580077
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21038103
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19943562
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19826243
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19570380
61DROSHA_22980978_ChIP-Seq_HELA_Human1.19092240
62TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18677186
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18669603
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18275676
65RNF2_27304074_Chip-Seq_NSC_Mouse1.17427042
66SMAD3_21741376_ChIP-Seq_HESCs_Human1.17000110
67MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13008933
68ISL1_27105846_Chip-Seq_CPCs_Mouse1.12562481
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12356827
70CJUN_26792858_Chip-Seq_BT549_Human1.11723911
71* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11197411
72IGF1R_20145208_ChIP-Seq_DFB_Human1.11138117
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10423191
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.10292452
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10215849
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10097248
77* STAT3_23295773_ChIP-Seq_U87_Human1.09507606
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09315284
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.08754623
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08520221
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08305980
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06550816
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06334915
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05699134
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05418946
86P300_19829295_ChIP-Seq_ESCs_Human1.04282932
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04054820
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03876306
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01848993
90BCAT_22108803_ChIP-Seq_LS180_Human1.00503573
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99954033
92TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99784568
93TP53_18474530_ChIP-ChIP_U2OS_Human0.98990473
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98678025
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98156408
96TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97776418
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97675644
98SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96985573
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96622200
100STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96197734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.16566314
2MP0002837_dystrophic_cardiac_calcinosis5.32701489
3MP0000751_myopathy4.54497102
4MP0004215_abnormal_myocardial_fiber4.35743241
5MP0004036_abnormal_muscle_relaxation3.76232476
6MP0005330_cardiomyopathy3.43090552
7MP0004510_myositis2.99154914
8MP0002972_abnormal_cardiac_muscle2.95296491
9MP0003137_abnormal_impulse_conducting2.84242457
10MP0004484_altered_response_of2.70714677
11MP0004087_abnormal_muscle_fiber2.67595466
12MP0010630_abnormal_cardiac_muscle2.57123861
13MP0000749_muscle_degeneration2.47479914
14MP0005385_cardiovascular_system_phenoty2.44638112
15MP0001544_abnormal_cardiovascular_syste2.44638112
16MP0006138_congestive_heart_failure2.44249407
17MP0005620_abnormal_muscle_contractility2.40873287
18MP0010368_abnormal_lymphatic_system2.40265331
19MP0004859_abnormal_synaptic_plasticity2.39559850
20MP0002877_abnormal_melanocyte_morpholog2.34156880
21MP0008775_abnormal_heart_ventricle2.32626505
22MP0002127_abnormal_cardiovascular_syste2.19927003
23MP0004085_abnormal_heartbeat2.14713815
24MP0003646_muscle_fatigue2.14059399
25MP0005503_abnormal_tendon_morphology2.08401581
26MP0005670_abnormal_white_adipose1.97608675
27MP0002269_muscular_atrophy1.87722154
28MP0000747_muscle_weakness1.75427881
29MP0002106_abnormal_muscle_physiology1.75150124
30MP0004130_abnormal_muscle_cell1.72681957
31MP0001879_abnormal_lymphatic_vessel1.71701748
32MP0005369_muscle_phenotype1.56693266
33MP0004272_abnormal_basement_membrane1.51276197
34MP0002735_abnormal_chemical_nociception1.49768874
35MP0000778_abnormal_nervous_system1.36112282
36MP0001984_abnormal_olfaction1.34971902
37MP0004145_abnormal_muscle_electrophysio1.33727784
38MP0003221_abnormal_cardiomyocyte_apopto1.31748349
39MP0000750_abnormal_muscle_regeneration1.29585918
40MP0002909_abnormal_adrenal_gland1.28100610
41MP0004270_analgesia1.23876343
42MP0003279_aneurysm1.18441201
43MP0000759_abnormal_skeletal_muscle1.16829058
44MP0002108_abnormal_muscle_morphology1.15502878
45MP0008438_abnormal_cutaneous_collagen1.15380183
46MP0005165_increased_susceptibility_to1.12979877
47MP0001958_emphysema1.11378809
48MP0000266_abnormal_heart_morphology1.04655251
49MP0004885_abnormal_endolymph1.02777453
50MP0001542_abnormal_bone_strength0.98697433
51MP0003828_pulmonary_edema0.97178548
52MP0005423_abnormal_somatic_nervous0.95653451
53MP0002736_abnormal_nociception_after0.91845579
54MP0002128_abnormal_blood_circulation0.90420087
55MP0003122_maternal_imprinting0.89002054
56MP0002009_preneoplasia0.88465521
57MP0005275_abnormal_skin_tensile0.88090702
58MP0005187_abnormal_penis_morphology0.86443281
59MP0003567_abnormal_fetal_cardiomyocyte0.82714914
60MP0005377_hearing/vestibular/ear_phenot0.77726722
61MP0003878_abnormal_ear_physiology0.77726722
62MP0002638_abnormal_pupillary_reflex0.76141400
63MP0003635_abnormal_synaptic_transmissio0.75342999
64MP0002063_abnormal_learning/memory/cond0.75180791
65MP0001299_abnormal_eye_distance/0.74535105
66MP0002572_abnormal_emotion/affect_behav0.70335103
67MP0002234_abnormal_pharynx_morphology0.69312515
68MP0003634_abnormal_glial_cell0.68639475
69MP0002332_abnormal_exercise_endurance0.67612171
70MP0000767_abnormal_smooth_muscle0.67504890
71MP0005666_abnormal_adipose_tissue0.67432893
72MP0008569_lethality_at_weaning0.64848029
73MP0009745_abnormal_behavioral_response0.64772120
74MP0005257_abnormal_intraocular_pressure0.64327317
75MP0002295_abnormal_pulmonary_circulatio0.64121904
76MP0000013_abnormal_adipose_tissue0.63762832
77MP0005409_darkened_coat_color0.63625431
78MP0005386_behavior/neurological_phenoty0.62530058
79MP0004924_abnormal_behavior0.62530058
80MP0008004_abnormal_stomach_pH0.62398712
81MP0000762_abnormal_tongue_morphology0.60022130
82MP0005171_absent_coat_pigmentation0.57523480
83MP0000955_abnormal_spinal_cord0.56724970
84MP0003091_abnormal_cell_migration0.56258782
85MP0001502_abnormal_circadian_rhythm0.56210631
86MP0001486_abnormal_startle_reflex0.55308321
87MP0005375_adipose_tissue_phenotype0.55269935
88MP0002925_abnormal_cardiovascular_devel0.55119378
89MP0005595_abnormal_vascular_smooth0.54808297
90MP0000230_abnormal_systemic_arterial0.54177392
91MP0002734_abnormal_mechanical_nocicepti0.53933264
92MP0001188_hyperpigmentation0.52878993
93MP0003136_yellow_coat_color0.52195824
94MP0004811_abnormal_neuron_physiology0.51921647
95MP0000733_abnormal_muscle_development0.51137002
96MP0009384_cardiac_valve_regurgitation0.50043699
97MP0002067_abnormal_sensory_capabilities0.50000862
98MP0000343_altered_response_to0.49887628
99MP0002066_abnormal_motor_capabilities/c0.48699641
100MP0002882_abnormal_neuron_morphology0.48658570

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.63589700
2Bundle branch block (HP:0011710)7.65412473
3Atrial fibrillation (HP:0005110)6.37478907
4Ventricular tachycardia (HP:0004756)6.06762226
5Primary atrial arrhythmia (HP:0001692)5.78639786
6Supraventricular tachycardia (HP:0004755)5.55551047
7Supraventricular arrhythmia (HP:0005115)5.52995745
8Hyporeflexia of lower limbs (HP:0002600)5.48368907
9Syncope (HP:0001279)5.31476811
10Right ventricular cardiomyopathy (HP:0011663)5.09907688
11Lipoatrophy (HP:0100578)4.83081741
12Abnormality of the calf musculature (HP:0001430)4.74432725
13Heart block (HP:0012722)4.68028495
14Abnormality of the left ventricular outflow tract (HP:0011103)4.63351810
15Subaortic stenosis (HP:0001682)4.63351810
16Abnormal atrioventricular conduction (HP:0005150)4.38920532
17Atrioventricular block (HP:0001678)4.33586658
18Asymmetric septal hypertrophy (HP:0001670)4.22339131
19Dilated cardiomyopathy (HP:0001644)4.20222686
20Ventricular arrhythmia (HP:0004308)3.98946540
21Muscle fiber splitting (HP:0003555)3.98094666
22Calf muscle hypertrophy (HP:0008981)3.72401549
23EMG: neuropathic changes (HP:0003445)3.63797452
24Neonatal short-limb short stature (HP:0008921)3.58882418
25Exercise-induced muscle cramps (HP:0003710)3.51142318
26EMG: myopathic abnormalities (HP:0003458)3.47260409
27Distal lower limb muscle weakness (HP:0009053)3.37477094
28Abnormality of the foot musculature (HP:0001436)3.30862051
29Muscle hypertrophy of the lower extremities (HP:0008968)3.30295432
30Prolonged QT interval (HP:0001657)3.29566066
31Ventricular fibrillation (HP:0001663)3.23228262
32Difficulty running (HP:0009046)3.22608757
33Atrophic scars (HP:0001075)3.22176607
34Morphological abnormality of the middle ear (HP:0008609)3.18522518
35Type 1 muscle fiber predominance (HP:0003803)3.17866064
36Palpitations (HP:0001962)3.15177841
37Left ventricular hypertrophy (HP:0001712)2.98634975
38Pheochromocytoma (HP:0002666)2.80822953
39Foot dorsiflexor weakness (HP:0009027)2.80611655
40Protrusio acetabuli (HP:0003179)2.74093131
41Areflexia of lower limbs (HP:0002522)2.73529748
42Mild short stature (HP:0003502)2.72212787
43Vascular tortuosity (HP:0004948)2.69228505
44Abnormal EKG (HP:0003115)2.68144317
45Scapular winging (HP:0003691)2.57858900
46Myoglobinuria (HP:0002913)2.56544885
47Steppage gait (HP:0003376)2.56369136
48Vertebral arch anomaly (HP:0008438)2.55993326
49Increased variability in muscle fiber diameter (HP:0003557)2.52711482
50Abnormality of the ischium (HP:0003174)2.43831800
51Soft skin (HP:0000977)2.42268996
52Rimmed vacuoles (HP:0003805)2.38175838
53Neck muscle weakness (HP:0000467)2.35273797
54Arterial tortuosity (HP:0005116)2.33929485
55Wide anterior fontanel (HP:0000260)2.33777248
56Abnormality of dentin (HP:0010299)2.32595251
57Genu recurvatum (HP:0002816)2.31544864
58Sudden cardiac death (HP:0001645)2.28644113
59Difficulty climbing stairs (HP:0003551)2.28221295
60Infantile muscular hypotonia (HP:0008947)2.28189632
61Breech presentation (HP:0001623)2.26420054
62Limb-girdle muscle atrophy (HP:0003797)2.25724927
63Calcaneovalgus deformity (HP:0001848)2.23980105
64Mildly elevated creatine phosphokinase (HP:0008180)2.23263134
65Abnormality of skeletal muscle fiber size (HP:0012084)2.21552888
66Neuroendocrine neoplasm (HP:0100634)2.18435073
67Increased connective tissue (HP:0009025)2.12713242
68Exercise-induced myalgia (HP:0003738)2.12694041
69Centrally nucleated skeletal muscle fibers (HP:0003687)2.08128534
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.06890555
71Rhabdomyolysis (HP:0003201)2.06712359
72Ragged-red muscle fibers (HP:0003200)2.04197890
73Abnormality of the shoulder girdle musculature (HP:0001435)2.03938815
74Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.01991209
75Nonimmune hydrops fetalis (HP:0001790)2.00696673
76Bradycardia (HP:0001662)1.97061112
77Hypoplasia of the iris (HP:0007676)1.96826779
78Deformed tarsal bones (HP:0008119)1.93211910
79Hypoplastic left heart (HP:0004383)1.92920439
80Proximal amyotrophy (HP:0007126)1.90407669
81Palmoplantar keratoderma (HP:0000982)1.89695674
82Congestive heart failure (HP:0001635)1.89143569
83Frequent falls (HP:0002359)1.88539404
84Muscle fiber inclusion bodies (HP:0100299)1.87775828
85Abnormality of the tricuspid valve (HP:0001702)1.83995062
86Nemaline bodies (HP:0003798)1.77633334
87Generalized muscle weakness (HP:0003324)1.77336273
88Hammertoe (HP:0001765)1.74925081
89Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.74455768
90Pulmonary artery stenosis (HP:0004415)1.72882940
91Myotonia (HP:0002486)1.72092795
92Peritonitis (HP:0002586)1.68614984
93Delayed gross motor development (HP:0002194)1.68577769
94Resting tremor (HP:0002322)1.68522293
95Cerebral hemorrhage (HP:0001342)1.67008798
96Mitral valve prolapse (HP:0001634)1.66437656
97Tibial bowing (HP:0002982)1.63269960
98Premature rupture of membranes (HP:0001788)1.61452498
99Complete atrioventricular canal defect (HP:0001674)1.61041846
100Dysmetric saccades (HP:0000641)1.60401296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.04485216
2TTN4.61657366
3MYLK4.48128957
4MARK13.83595606
5OBSCN3.32753716
6NTRK13.23974387
7DMPK3.23034617
8MOS2.23554559
9PAK32.21016690
10SIK22.04910176
11EPHB22.04332363
12ROCK21.99378913
13CAMK2D1.85382198
14NEK91.75627650
15ROCK11.71404322
16NTRK21.68325375
17MUSK1.57202731
18CASK1.52703038
19STK241.49346296
20PAK61.46990389
21PKN21.46020023
22RIPK11.44781059
23BCR1.43438993
24PRKD11.28624871
25UHMK11.26749977
26PINK11.25805563
27PNCK1.23203449
28LATS21.20125410
29NEK21.16785331
30CAMK2A1.13153024
31PRKCE1.12076909
32CDK121.09179429
33MAP3K60.98461397
34CAMK2B0.96419529
35STK40.93606785
36PIK3CA0.86451723
37CDC42BPA0.85396858
38STK390.84523806
39PDGFRA0.81955205
40CDK50.77969479
41RPS6KC10.75812119
42RPS6KL10.75812119
43PAK20.73337924
44KSR10.72942560
45MAP3K40.71070842
46STK38L0.70890751
47PHKG20.70257430
48PHKG10.70257430
49GRK70.69857647
50LMTK20.69610934
51SGK20.68977005
52PRKAA10.67606019
53EPHA30.67414975
54RPS6KA60.66675270
55MAP3K100.66290353
56RPS6KA40.65796717
57MAP2K10.64627268
58YES10.64440737
59CAMK2G0.63963548
60MAPK120.62418232
61MAP3K70.61252157
62BRD40.60318859
63ARAF0.59165916
64WNK10.57579370
65TIE10.57087484
66MAPK100.56489731
67PLK20.55538458
68MAP3K90.54185772
69PDGFRB0.54135914
70PDK20.53996527
71TYRO30.52776823
72RPS6KA10.52106629
73CSNK1G20.51714000
74FER0.51543407
75MAPKAPK30.49605267
76PRKCG0.49343240
77PRKACB0.48832905
78PKN10.48348124
79PRKAA20.48030155
80MAPK40.47231055
81PRKG10.47193149
82PRKACG0.47137610
83MTOR0.45687459
84SGK2230.44306033
85SGK4940.44306033
86LATS10.43917095
87MAP3K50.43906640
88RPS6KA30.38876539
89SGK30.38819138
90PRKACA0.38274153
91LIMK10.36721219
92MAPK90.35900146
93TRIB30.34630434
94TGFBR20.34196081
95CAMK10.33100482
96ERBB30.32711878
97CAMK1G0.29955929
98RPS6KA20.29357894
99KSR20.28861988
100RPS6KB10.28661451

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054144.95724225
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.54114142
3Cardiac muscle contraction_Homo sapiens_hsa042603.64795047
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.29124222
5Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.57200342
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.44951587
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40075682
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36517559
9Circadian entrainment_Homo sapiens_hsa047131.88669276
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.83460300
11cGMP-PKG signaling pathway_Homo sapiens_hsa040221.57514752
12Nicotine addiction_Homo sapiens_hsa050331.46496746
13cAMP signaling pathway_Homo sapiens_hsa040241.44194747
14Propanoate metabolism_Homo sapiens_hsa006401.42840413
15ECM-receptor interaction_Homo sapiens_hsa045121.41503446
16Focal adhesion_Homo sapiens_hsa045101.40542627
17Adherens junction_Homo sapiens_hsa045201.40203543
18Renin secretion_Homo sapiens_hsa049241.38142718
19Amphetamine addiction_Homo sapiens_hsa050311.37572701
20Circadian rhythm_Homo sapiens_hsa047101.34726627
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.34510396
22Long-term potentiation_Homo sapiens_hsa047201.31251914
23Dorso-ventral axis formation_Homo sapiens_hsa043201.28211031
24Gap junction_Homo sapiens_hsa045401.23422057
25Oxytocin signaling pathway_Homo sapiens_hsa049211.21905784
26Glutamatergic synapse_Homo sapiens_hsa047241.19859125
27Tight junction_Homo sapiens_hsa045301.19782324
28Cocaine addiction_Homo sapiens_hsa050301.15990567
29Cholinergic synapse_Homo sapiens_hsa047251.15533959
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13696922
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.13553018
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13393333
33Morphine addiction_Homo sapiens_hsa050321.09188582
34Protein digestion and absorption_Homo sapiens_hsa049741.06827927
35Carbon metabolism_Homo sapiens_hsa012001.06265924
36Calcium signaling pathway_Homo sapiens_hsa040201.04356222
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02813664
38Renal cell carcinoma_Homo sapiens_hsa052111.02715442
39Axon guidance_Homo sapiens_hsa043601.00462678
40Dopaminergic synapse_Homo sapiens_hsa047280.97145352
41PPAR signaling pathway_Homo sapiens_hsa033200.96607589
42GABAergic synapse_Homo sapiens_hsa047270.96512818
43Insulin secretion_Homo sapiens_hsa049110.91460681
44Insulin signaling pathway_Homo sapiens_hsa049100.88937233
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87869617
46Melanogenesis_Homo sapiens_hsa049160.85705777
47Amoebiasis_Homo sapiens_hsa051460.84652763
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84528873
49Ovarian steroidogenesis_Homo sapiens_hsa049130.81018342
50Pancreatic secretion_Homo sapiens_hsa049720.80214590
51Viral myocarditis_Homo sapiens_hsa054160.79902375
52Gastric acid secretion_Homo sapiens_hsa049710.77367683
53Type II diabetes mellitus_Homo sapiens_hsa049300.75859546
54Fatty acid degradation_Homo sapiens_hsa000710.75824253
55Fatty acid metabolism_Homo sapiens_hsa012120.75138014
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74444962
57Insulin resistance_Homo sapiens_hsa049310.73075256
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72951000
59Endometrial cancer_Homo sapiens_hsa052130.72879186
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69406723
61Glucagon signaling pathway_Homo sapiens_hsa049220.68812492
62Hedgehog signaling pathway_Homo sapiens_hsa043400.67671316
63AMPK signaling pathway_Homo sapiens_hsa041520.67405835
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67228292
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.66472925
66Platelet activation_Homo sapiens_hsa046110.64949501
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63790999
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.63209825
69Thyroid hormone synthesis_Homo sapiens_hsa049180.63069100
70Pyruvate metabolism_Homo sapiens_hsa006200.61483359
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60618520
72Rap1 signaling pathway_Homo sapiens_hsa040150.59799693
73Serotonergic synapse_Homo sapiens_hsa047260.59756517
74Long-term depression_Homo sapiens_hsa047300.59221600
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55062072
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54725276
77Taste transduction_Homo sapiens_hsa047420.54350897
78Estrogen signaling pathway_Homo sapiens_hsa049150.52226882
79Prion diseases_Homo sapiens_hsa050200.50501712
80Ras signaling pathway_Homo sapiens_hsa040140.49969365
81GnRH signaling pathway_Homo sapiens_hsa049120.49722432
82Salivary secretion_Homo sapiens_hsa049700.49393471
83HIF-1 signaling pathway_Homo sapiens_hsa040660.49177610
84Phenylalanine metabolism_Homo sapiens_hsa003600.48505332
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46363912
86mTOR signaling pathway_Homo sapiens_hsa041500.45747613
87Butanoate metabolism_Homo sapiens_hsa006500.43206403
88Arginine and proline metabolism_Homo sapiens_hsa003300.41545976
89Biosynthesis of amino acids_Homo sapiens_hsa012300.41062819
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.40763075
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.39170187
92Colorectal cancer_Homo sapiens_hsa052100.38470037
93MAPK signaling pathway_Homo sapiens_hsa040100.38401225
94Proteoglycans in cancer_Homo sapiens_hsa052050.38332915
95Hippo signaling pathway_Homo sapiens_hsa043900.35413295
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34585276
97Alzheimers disease_Homo sapiens_hsa050100.33666364
98VEGF signaling pathway_Homo sapiens_hsa043700.33562242
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.33342418
100Olfactory transduction_Homo sapiens_hsa047400.32168406

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