ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.30810715
2	L-phenylalanine catabolic process (GO:0006559)	7.30810715
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.12210148
4	L-phenylalanine metabolic process (GO:0006558)	7.12210148
5	aromatic amino acid family catabolic process (GO:0009074)	6.55778515
6	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.22014488
7	tryptophan catabolic process (GO:0006569)	5.92076469
8	indole-containing compound catabolic process (GO:0042436)	5.92076469
9	indolalkylamine catabolic process (GO:0046218)	5.92076469
10	kynurenine metabolic process (GO:0070189)	5.89472065
11	glyoxylate metabolic process (GO:0046487)	5.86867775
12	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.71128023
13	bile acid biosynthetic process (GO:0006699)	5.63640570
14	ribosomal small subunit biogenesis (GO:0042274)	5.60245238
15	tryptophan metabolic process (GO:0006568)	5.56412666
16	alpha-linolenic acid metabolic process (GO:0036109)	5.43100114
17	cysteine metabolic process (GO:0006534)	5.39584578
18	sulfur amino acid catabolic process (GO:0000098)	5.34915986
19	urea metabolic process (GO:0019627)	5.31372201
20	urea cycle (GO:0000050)	5.31372201
21	high-density lipoprotein particle remodeling (GO:0034375)	5.31298865
22	serine family amino acid catabolic process (GO:0009071)	5.27705556
23	negative regulation of fibrinolysis (GO:0051918)	5.24484480
24	ribosomal small subunit assembly (GO:0000028)	5.22573549
25	lysine catabolic process (GO:0006554)	5.07860973
26	lysine metabolic process (GO:0006553)	5.07860973
27	regulation of fibrinolysis (GO:0051917)	5.00807146
28	protein carboxylation (GO:0018214)	4.98412631
29	peptidyl-glutamic acid carboxylation (GO:0017187)	4.98412631
30	nitrogen cycle metabolic process (GO:0071941)	4.90983576
31	regulation of protein activation cascade (GO:2000257)	4.90349385
32	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.89571974
33	regulation of triglyceride catabolic process (GO:0010896)	4.89347819
34	regulation of cholesterol esterification (GO:0010872)	4.88972424
35	complement activation, alternative pathway (GO:0006957)	4.86361311
36	exogenous drug catabolic process (GO:0042738)	4.83183022
37	aromatic amino acid family metabolic process (GO:0009072)	4.82007693
38	viral transcription (GO:0019083)	4.81497758
39	amino-acid betaine metabolic process (GO:0006577)	4.80608956
40	bile acid metabolic process (GO:0008206)	4.80178400
41	homocysteine metabolic process (GO:0050667)	4.79601500
42	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.79121473
43	alpha-amino acid catabolic process (GO:1901606)	4.71668669
44	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.68387127
45	reverse cholesterol transport (GO:0043691)	4.66200729
46	plasma lipoprotein particle remodeling (GO:0034369)	4.65124059
47	protein-lipid complex remodeling (GO:0034368)	4.65124059
48	macromolecular complex remodeling (GO:0034367)	4.65124059
49	epoxygenase P450 pathway (GO:0019373)	4.64193665
50	cellular ketone body metabolic process (GO:0046950)	4.62021166
51	regulation of complement activation (GO:0030449)	4.57864036
52	glycine metabolic process (GO:0006544)	4.56593641
53	translational termination (GO:0006415)	4.53901011
54	tyrosine metabolic process (GO:0006570)	4.52150685
55	ATP synthesis coupled proton transport (GO:0015986)	4.47756087
56	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.47756087
57	negative regulation of cholesterol transport (GO:0032375)	4.43827281
58	negative regulation of sterol transport (GO:0032372)	4.43827281
59	triglyceride homeostasis (GO:0070328)	4.43785577
60	acylglycerol homeostasis (GO:0055090)	4.43785577
61	cellular amino acid catabolic process (GO:0009063)	4.38385455
62	phospholipid efflux (GO:0033700)	4.36748173
63	serine family amino acid metabolic process (GO:0009069)	4.33887080
64	coenzyme catabolic process (GO:0009109)	4.30994651
65	ethanol oxidation (GO:0006069)	4.27593753
66	plasma lipoprotein particle clearance (GO:0034381)	4.27331267
67	glutamate metabolic process (GO:0006536)	4.19274528
68	serine family amino acid biosynthetic process (GO:0009070)	4.17310830
69	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.15513621
70	indolalkylamine metabolic process (GO:0006586)	4.15389131
71	amine catabolic process (GO:0009310)	4.12688777
72	cellular biogenic amine catabolic process (GO:0042402)	4.12688777
73	cellular modified amino acid catabolic process (GO:0042219)	4.11196558
74	short-chain fatty acid metabolic process (GO:0046459)	4.09958409
75	omega-hydroxylase P450 pathway (GO:0097267)	4.06780231
76	imidazole-containing compound metabolic process (GO:0052803)	4.06712445
77	dicarboxylic acid biosynthetic process (GO:0043650)	4.01598589
78	acetyl-CoA metabolic process (GO:0006084)	4.00744395
79	aspartate family amino acid catabolic process (GO:0009068)	4.00328442
80	bile acid and bile salt transport (GO:0015721)	4.00167923
81	low-density lipoprotein particle remodeling (GO:0034374)	3.99085447
82	translational elongation (GO:0006414)	3.98985153
83	maturation of SSU-rRNA (GO:0030490)	3.98957881
84	ketone body metabolic process (GO:1902224)	3.98839717
85	benzene-containing compound metabolic process (GO:0042537)	3.98051932
86	pyrimidine nucleotide catabolic process (GO:0006244)	3.97774195
87	cellular glucuronidation (GO:0052695)	3.97376426
88	2-oxoglutarate metabolic process (GO:0006103)	3.94331880
89	cholesterol efflux (GO:0033344)	3.92464145
90	organic acid catabolic process (GO:0016054)	3.92281643
91	carboxylic acid catabolic process (GO:0046395)	3.92281643
92	arginine metabolic process (GO:0006525)	3.91521322
93	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.87633672
94	plasma lipoprotein particle assembly (GO:0034377)	3.85821986
95	fatty acid beta-oxidation (GO:0006635)	3.82752519
96	aldehyde catabolic process (GO:0046185)	3.81993956
97	drug catabolic process (GO:0042737)	3.79760190
98	cotranslational protein targeting to membrane (GO:0006613)	3.78589569
99	protein targeting to ER (GO:0045047)	3.77616551
100	fatty acid oxidation (GO:0019395)	3.75309115
101	drug metabolic process (GO:0017144)	3.75212892
102	phospholipid homeostasis (GO:0055091)	3.71669139
103	monocarboxylic acid catabolic process (GO:0072329)	3.71169762
104	regulation of mitochondrial translation (GO:0070129)	3.71131350
105	lipid oxidation (GO:0034440)	3.69954473
106	carnitine metabolic process (GO:0009437)	3.69708222
107	positive regulation of triglyceride lipase activity (GO:0061365)	3.69285621
108	positive regulation of lipoprotein lipase activity (GO:0051006)	3.69285621
109	positive regulation of lipid catabolic process (GO:0050996)	3.67849812
110	cofactor catabolic process (GO:0051187)	3.67241394
111	L-serine metabolic process (GO:0006563)	3.66688310
112	DNA strand elongation involved in DNA replication (GO:0006271)	3.66460879
113	fibrinolysis (GO:0042730)	3.66417281
114	protein localization to endoplasmic reticulum (GO:0070972)	3.65886242
115	respiratory electron transport chain (GO:0022904)	3.65104051
116	fatty acid catabolic process (GO:0009062)	3.64228601
117	cholesterol homeostasis (GO:0042632)	3.63673941
118	very-low-density lipoprotein particle assembly (GO:0034379)	3.63625361
119	viral life cycle (GO:0019058)	3.62933765
120	negative regulation of lipase activity (GO:0060192)	3.61229801
121	cellular protein complex disassembly (GO:0043624)	3.60391934
122	blood coagulation, intrinsic pathway (GO:0007597)	3.60078065
123	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.57740500
124	sterol homeostasis (GO:0055092)	3.57531343
125	polyketide metabolic process (GO:0030638)	3.56460980
126	doxorubicin metabolic process (GO:0044598)	3.56460980
127	daunorubicin metabolic process (GO:0044597)	3.56460980
128	phenylpropanoid metabolic process (GO:0009698)	3.56020328
129	regulation of bile acid biosynthetic process (GO:0070857)	3.55900835
130	DNA strand elongation (GO:0022616)	3.54964175
131	electron transport chain (GO:0022900)	3.54804245
132	heme transport (GO:0015886)	3.53840325
133	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.53151841
134	plasma lipoprotein particle organization (GO:0071827)	3.51807480
135	oxidative phosphorylation (GO:0006119)	3.49465921
136	chaperone-mediated protein transport (GO:0072321)	3.44531070
137	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.43734078
138	telomere maintenance via semi-conservative replication (GO:0032201)	3.37760907
139	oxidative demethylation (GO:0070989)	3.34822512
140	deoxyribose phosphate biosynthetic process (GO:0046385)	3.34083116
141	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.34083116
142	protein complex biogenesis (GO:0070271)	3.33093337
143	uronic acid metabolic process (GO:0006063)	3.30263381
144	glucuronate metabolic process (GO:0019585)	3.30263381
145	protein complex disassembly (GO:0043241)	3.25130883
146	response to misfolded protein (GO:0051788)	3.24716957
147	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.23509740
148	proline metabolic process (GO:0006560)	3.23340278
149	deoxyribonucleotide catabolic process (GO:0009264)	3.22415903
150	NADH metabolic process (GO:0006734)	3.22294917
151	ethanol metabolic process (GO:0006067)	3.19662199
152	aminoglycoside antibiotic metabolic process (GO:0030647)	3.18991961
153	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.15920002
154	NADH dehydrogenase complex assembly (GO:0010257)	3.15920002
155	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.15920002
156	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.15866994
157	metallo-sulfur cluster assembly (GO:0031163)	3.12689280
158	iron-sulfur cluster assembly (GO:0016226)	3.12689280
159	ncRNA 3-end processing (GO:0043628)	3.10915144
160	mitochondrial respiratory chain complex assembly (GO:0033108)	3.10649594
161	macromolecular complex disassembly (GO:0032984)	3.07220372
162	deoxyribose phosphate catabolic process (GO:0046386)	3.04532351
163	DNA unwinding involved in DNA replication (GO:0006268)	3.01195134
164	translational initiation (GO:0006413)	2.97368679
165	oxaloacetate metabolic process (GO:0006107)	2.95691569
166	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.92907078
167	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.85801950
168	quinone metabolic process (GO:1901661)	2.84921457
169	quinone biosynthetic process (GO:1901663)	2.81496961
170	ribosomal large subunit biogenesis (GO:0042273)	2.80940305

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	8.16577543
2	PPARA_22158963_ChIP-Seq_LIVER_Mouse	7.08230350
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.61744536
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	6.27294871
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	5.94735121
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.19440952
7	E2F7_22180533_ChIP-Seq_HELA_Human	5.11873335
8	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	5.05170316
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.16819554
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.95337804
11	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.85449475
12	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.34239852
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.27501076
14	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.18423570
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.84423210
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.82982458
17	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.61236401
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.50608289
19	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.45063322
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.28675468
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.27689536
22	XRN2_22483619_ChIP-Seq_HELA_Human	2.23757093
23	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.18778128
24	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.15978006
25	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.00974907
26	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.7644535
27	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.95487437
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.91301587
29	VDR_21846776_ChIP-Seq_THP-1_Human	1.90459255
30	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.88021544
31	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.81468070
32	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.80892644
33	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.80598777
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.80447351
35	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.72396560
36	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.68671770
37	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.64080054
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.63849143
39	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.61193199
40	* CLOCK_20551151_ChIP-Seq_293T_Human	1.59315876
41	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.57236778
42	P68_20966046_ChIP-Seq_HELA_Human	1.57148573
43	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.52459778
44	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.51346900
45	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.51182826
46	GATA1_22025678_ChIP-Seq_K562_Human	1.51133083
47	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.49375313
48	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.47905064
49	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.47432517
50	BCL6_27268052_Chip-Seq_Bcells_Human	1.45138776
51	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.43424981
52	HTT_18923047_ChIP-ChIP_STHdh_Human	1.40589278
53	DCP1A_22483619_ChIP-Seq_HELA_Human	1.39550146
54	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.39292147
55	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.36599038
56	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.36270942
57	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.35448194
58	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.34618949
59	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.34398468
60	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.34005301
61	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.31782159
62	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.30281720
63	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.30039282
64	* TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.28275669
65	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.25815685
66	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.23496138
67	KDM5A_27292631_Chip-Seq_BREAST_Human	1.22254655
68	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.21350118
69	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.20520248
70	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20125644
71	PHF8_20622854_ChIP-Seq_HELA_Human	1.19348238
72	* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.18541656
73	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.17068262
74	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.15345969
75	ZNF263_19887448_ChIP-Seq_K562_Human	1.15282669
76	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.15040181
77	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.14095192
78	* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.14072675
79	E2F1_20622854_ChIP-Seq_HELA_Human	1.13355961
80	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11317303
81	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.08036142
82	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.07544845
83	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.06937150
84	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.06567637
85	CTCF_20526341_ChIP-Seq_ESCs_Human	1.06456069
86	SMC4_20622854_ChIP-Seq_HELA_Human	1.05181132
87	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.04614180
88	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.04550497
89	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.04215462
90	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.04113297
91	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.03018854
92	SA1_27219007_Chip-Seq_Bcells_Human	1.03016798
93	CIITA_25753668_ChIP-Seq_RAJI_Human	1.02682057
94	MYC_22102868_ChIP-Seq_BL_Human	1.01132766
95	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.00727680
96	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.00451438
97	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.98703799
98	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.98382734
99	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.98373920
100	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.97047023
101	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.96547843
102	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.95561690
103	* ERG_21242973_ChIP-ChIP_JURKAT_Human	0.95351345
104	CTCF_21964334_Chip-Seq_Bcells_Human	0.94966967
105	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.94575552
106	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.93822133
107	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.93471187
108	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.89638616
109	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.84802066
110	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.83711816
111	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.81177342
112	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.79809597
113	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.79418706
114	GATA4_25053715_ChIP-Seq_YYC3_Human	0.79313779
115	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.78494637
116	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.77139109
117	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.69275479
118	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.69021194
119	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.68810933
120	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.68565423
121	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.67797723
122	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.67608513
123	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.66708712
124	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.62015367
125	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.61947002
126	CEBPB_22108803_ChIP-Seq_LS180_Human	0.61478145
127	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.58114145
128	LXR_22292898_ChIP-Seq_THP-1_Human	0.57451055
129	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.55560905
130	* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.54320434
131	AR_20517297_ChIP-Seq_VCAP_Human	0.53174079
132	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.52128019
133	TAF2_19829295_ChIP-Seq_ESCs_Human	0.50296820
134	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.49988336
135	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.49668639
136	P53_21459846_ChIP-Seq_SAOS-2_Human	0.49647035
137	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.48531125
138	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.48531125
139	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.48013863
140	BCOR_27268052_Chip-Seq_Bcells_Human	0.47769593
141	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.47500320
142	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.47191270
143	* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.46357355
144	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.46236411
145	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.45037959
146	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.44925827
147	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.44725897
148	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.44286482
149	CBP_21632823_ChIP-Seq_H3396_Human	0.44239936
150	EGR1_19032775_ChIP-ChIP_M12_Human	0.44086802
151	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.43440154
152	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.42352483
153	MYC_19915707_ChIP-ChIP_AK7_Human	0.42257917
154	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.42142695
155	* FOXA1_25552417_ChIP-Seq_VCAP_Human	0.42121321
156	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.42113911
157	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.41714182
158	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.40867343
159	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.40775248
160	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.40775248
161	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.40421734
162	ERG_20517297_ChIP-Seq_VCAP_Human	0.40170035
163	* OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.40003412
164	GATA6_25053715_ChIP-Seq_YYC3_Human	0.39972142
165	AR_21909140_ChIP-Seq_LNCAP_Human	0.39965841
166	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.39278833
167	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.39170278
168	GATA1_19941826_ChIP-Seq_K562_Human	0.38972808
169	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.38873661
170	STAT1_17558387_ChIP-Seq_HELA_Human	0.38535395
171	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.38474897
172	RACK7_27058665_Chip-Seq_MCF-7_Human	0.38112245
173	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.37583170

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.92911466
2	MP0005360_urolithiasis	7.34918259
3	MP0005085_abnormal_gallbladder_physiolo	6.18200502
4	MP0005365_abnormal_bile_salt	5.93029892
5	MP0008875_abnormal_xenobiotic_pharmacok	4.93323576
6	MP0003806_abnormal_nucleotide_metabolis	4.47788905
7	MP0009840_abnormal_foam_cell	3.62844441
8	MP0003252_abnormal_bile_duct	3.62139059
9	MP0009379_abnormal_foot_pigmentation	3.49575522
10	MP0010329_abnormal_lipoprotein_level	3.47675954
11	MP0005332_abnormal_amino_acid	3.00644357
12	MP0005083_abnormal_biliary_tract	2.91431777
13	MP0003195_calcinosis	2.83057754
14	MP0001666_abnormal_nutrient_absorption	2.40274231
15	MP0003191_abnormal_cellular_cholesterol	2.32677867
16	MP0004019_abnormal_vitamin_homeostasis	2.13914626
17	MP0002118_abnormal_lipid_homeostasis	2.11538053
18	* MP0000609_abnormal_liver_physiology	2.10691515
19	MP0006292_abnormal_olfactory_placode	1.98231334
20	MP0005319_abnormal_enzyme/_coenzyme	1.93902416
21	MP0003693_abnormal_embryo_hatching	1.93552461
22	MP0010094_abnormal_chromosome_stability	1.93361927
23	MP0008932_abnormal_embryonic_tissue	1.80238425
24	MP0002138_abnormal_hepatobiliary_system	1.79010935
25	MP0008058_abnormal_DNA_repair	1.75771834
26	MP0001764_abnormal_homeostasis	1.74496919
27	MP0008789_abnormal_olfactory_epithelium	1.69502297
28	MP0004147_increased_porphyrin_level	1.69016511
29	MP0005584_abnormal_enzyme/coenzyme_acti	1.61797972
30	MP0002234_abnormal_pharynx_morphology	1.61519854
31	MP0003868_abnormal_feces_composition	1.60669318
32	MP0005451_abnormal_body_composition	1.59312836
33	MP0003186_abnormal_redox_activity	1.57712311
34	MP0000678_abnormal_parathyroid_gland	1.57441587
35	MP0009697_abnormal_copulation	1.52365144
36	MP0003111_abnormal_nucleus_morphology	1.48323105
37	MP0002653_abnormal_ependyma_morphology	1.43968001
38	MP0002249_abnormal_larynx_morphology	1.42204879
39	MP0003011_delayed_dark_adaptation	1.37803184
40	MP0003656_abnormal_erythrocyte_physiolo	1.37779238
41	MP0005645_abnormal_hypothalamus_physiol	1.36461755
42	MP0002160_abnormal_reproductive_system	1.35922558
43	MP0004145_abnormal_muscle_electrophysio	1.34896696
44	MP0006036_abnormal_mitochondrial_physio	1.33882856
45	* MP0009643_abnormal_urine_homeostasis	1.32631942
46	MP0002837_dystrophic_cardiac_calcinosis	1.31927856
47	MP0005397_hematopoietic_system_phenotyp	1.31651186
48	MP0001545_abnormal_hematopoietic_system	1.31651186
49	MP0002132_abnormal_respiratory_system	1.29963083
50	MP0005499_abnormal_olfactory_system	1.25245893
51	MP0005394_taste/olfaction_phenotype	1.25245893
52	MP0005670_abnormal_white_adipose	1.25120104
53	MP0004957_abnormal_blastocyst_morpholog	1.20756247
54	MP0003705_abnormal_hypodermis_morpholog	1.17993083
55	MP0000598_abnormal_liver_morphology	1.15679382
56	MP0003315_abnormal_perineum_morphology	1.13657967
57	MP0001727_abnormal_embryo_implantation	1.13241592
58	MP0004130_abnormal_muscle_cell	1.13184013
59	MP0005647_abnormal_sex_gland	1.13081330
60	MP0003786_premature_aging	1.08453494
61	MP0008007_abnormal_cellular_replicative	1.06617059
62	MP0003077_abnormal_cell_cycle	1.06264084
63	MP0003123_paternal_imprinting	1.06207355
64	MP0001905_abnormal_dopamine_level	1.05712667
65	MP0009278_abnormal_bone_marrow	1.05585905
66	MP0000604_amyloidosis	1.00610939
67	MP0005636_abnormal_mineral_homeostasis	0.98881964
68	MP0009763_increased_sensitivity_to	0.97834946
69	MP0009764_decreased_sensitivity_to	0.94563712
70	MP0002254_reproductive_system_inflammat	0.92564948
71	MP0010368_abnormal_lymphatic_system	0.89861183
72	MP0001529_abnormal_vocalization	0.89665862
73	MP0005410_abnormal_fertilization	0.89304774
74	MP0006035_abnormal_mitochondrial_morpho	0.86616985
75	MP0002971_abnormal_brown_adipose	0.85604286
76	* MP0009642_abnormal_blood_homeostasis	0.84729286
77	MP0008469_abnormal_protein_level	0.83150195
78	* MP0005376_homeostasis/metabolism_phenot	0.82536553
79	MP0002163_abnormal_gland_morphology	0.82388561
80	MP0000049_abnormal_middle_ear	0.82058386
81	MP0003646_muscle_fatigue	0.81835390
82	MP0001661_extended_life_span	0.81159447
83	MP0002078_abnormal_glucose_homeostasis	0.80682161
84	* MP0005266_abnormal_metabolism	0.75662054
85	MP0004142_abnormal_muscle_tone	0.75640640
86	MP0005666_abnormal_adipose_tissue	0.75284872
87	MP0005330_cardiomyopathy	0.74147137
88	MP0005389_reproductive_system_phenotype	0.73602727
89	MP0001756_abnormal_urination	0.72723479
90	MP0000681_abnormal_thyroid_gland	0.70742839
91	MP0005535_abnormal_body_temperature	0.70302776
92	MP0005334_abnormal_fat_pad	0.70216076
93	MP0002638_abnormal_pupillary_reflex	0.70162986
94	MP0005408_hypopigmentation	0.70021171
95	MP0005501_abnormal_skin_physiology	0.69525869
96	MP0003690_abnormal_glial_cell	0.69426075
97	MP0003329_amyloid_beta_deposits	0.68815644
98	MP0000490_abnormal_crypts_of	0.67464832
99	MP0009765_abnormal_xenobiotic_induced	0.64467673
100	MP0001929_abnormal_gametogenesis	0.64391352
101	MP0004858_abnormal_nervous_system	0.64384789
102	MP0005084_abnormal_gallbladder_morpholo	0.64074485
103	MP0002092_abnormal_eye_morphology	0.63932843
104	MP0003698_abnormal_male_reproductive	0.63382622
105	MP0003718_maternal_effect	0.62378951
106	MP0008995_early_reproductive_senescence	0.62061743
107	MP0000003_abnormal_adipose_tissue	0.61706030
108	MP0002269_muscular_atrophy	0.61673120
109	MP0002019_abnormal_tumor_incidence	0.61663042
110	MP0002876_abnormal_thyroid_physiology	0.61520609
111	MP0003879_abnormal_hair_cell	0.58402109
112	MP0000313_abnormal_cell_death	0.56488799
113	MP0001919_abnormal_reproductive_system	0.56371537
114	MP0000653_abnormal_sex_gland	0.55081227
115	MP0005220_abnormal_exocrine_pancreas	0.54944030
116	MP0005395_other_phenotype	0.52339240
117	MP0002136_abnormal_kidney_physiology	0.50762875
118	MP0004043_abnormal_pH_regulation	0.50247357
119	MP0009053_abnormal_anal_canal	0.48606143
120	MP0001853_heart_inflammation	0.47961928
121	MP0005448_abnormal_energy_balance	0.47606895
122	MP0000639_abnormal_adrenal_gland	0.47468008
123	MP0009115_abnormal_fat_cell	0.44757313
124	MP0003638_abnormal_response/metabolism_	0.44278863
125	MP0002332_abnormal_exercise_endurance	0.44097903
126	MP0000230_abnormal_systemic_arterial	0.43540134
127	MP0004036_abnormal_muscle_relaxation	0.41050020
128	MP0008873_increased_physiological_sensi	0.40858790
129	MP0003075_altered_response_to	0.39077575
130	MP0008874_decreased_physiological_sensi	0.38815716
131	MP0003953_abnormal_hormone_level	0.38618422
132	MP0003221_abnormal_cardiomyocyte_apopto	0.38106546
133	MP0001544_abnormal_cardiovascular_syste	0.37343542
134	MP0005385_cardiovascular_system_phenoty	0.37343542
135	MP0002970_abnormal_white_adipose	0.37031294
136	MP0009672_abnormal_birth_weight	0.36357100
137	MP0008872_abnormal_physiological_respon	0.35694829
138	MP0000579_abnormal_nail_morphology	0.34998915
139	MP0006138_congestive_heart_failure	0.34832746
140	MP0005165_increased_susceptibility_to	0.33563875
141	MP0004782_abnormal_surfactant_physiolog	0.32872761
142	MP0002822_catalepsy	0.32544257
143	MP0000249_abnormal_blood_vessel	0.32397516
144	MP0002796_impaired_skin_barrier	0.31318284
145	MP0004215_abnormal_myocardial_fiber	0.31273802
146	MP0004087_abnormal_muscle_fiber	0.30791283
147	MP0005464_abnormal_platelet_physiology	0.30525093
148	MP0005166_decreased_susceptibility_to	0.30286469
149	MP0004185_abnormal_adipocyte_glucose	0.29865705
150	MP0000749_muscle_degeneration	0.29847489
151	MP0000747_muscle_weakness	0.29692281

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.96003056
2	Intrahepatic cholestasis (HP:0001406)	6.69601345
3	Deep venous thrombosis (HP:0002625)	6.67517056
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.16390767
5	Xanthomatosis (HP:0000991)	6.07719881
6	Hypobetalipoproteinemia (HP:0003563)	5.86222083
7	Prolonged partial thromboplastin time (HP:0003645)	5.84594476
8	Hyperlipoproteinemia (HP:0010980)	5.49851831
9	Abnormal mitochondria in muscle tissue (HP:0008316)	5.02016180
10	Hyperammonemia (HP:0001987)	4.94242974
11	Hyperglycinemia (HP:0002154)	4.87278602
12	Hyperglycinuria (HP:0003108)	4.73178043
13	Complement deficiency (HP:0004431)	4.66995555
14	Hypolipoproteinemia (HP:0010981)	4.64642681
15	Ketosis (HP:0001946)	4.62128569
16	Abnormality of glycine metabolism (HP:0010895)	4.55275367
17	Abnormality of serine family amino acid metabolism (HP:0010894)	4.55275367
18	Acute necrotizing encephalopathy (HP:0006965)	4.48354792
19	Reticulocytopenia (HP:0001896)	4.37058251
20	Hypoalphalipoproteinemia (HP:0003233)	4.26954441
21	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.25865940
22	Joint hemorrhage (HP:0005261)	4.21421726
23	Hypoglycemic coma (HP:0001325)	4.21186569
24	Abnormality of methionine metabolism (HP:0010901)	4.20444232
25	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.14434839
26	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.13825045
27	Abnormality of cells of the erythroid lineage (HP:0012130)	4.13786146
28	Epidermoid cyst (HP:0200040)	4.09778917
29	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.02427809
30	Mitochondrial inheritance (HP:0001427)	3.94199344
31	Hepatocellular necrosis (HP:0001404)	3.91027022
32	Abnormality of fatty-acid metabolism (HP:0004359)	3.90113341
33	Increased muscle lipid content (HP:0009058)	3.87877927
34	Increased intramyocellular lipid droplets (HP:0012240)	3.87869773
35	Abnormality of the common coagulation pathway (HP:0010990)	3.85494707
36	Abnormal number of erythroid precursors (HP:0012131)	3.73202772
37	Abnormality of pyrimidine metabolism (HP:0004353)	3.67780601
38	Fat malabsorption (HP:0002630)	3.67547496
39	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.57824786
40	Ketoacidosis (HP:0001993)	3.55478161
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.47183550
42	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.47183550
43	Abnormality of serum amino acid levels (HP:0003112)	3.42366354
44	Increased CSF lactate (HP:0002490)	3.40932179
45	Hypercholesterolemia (HP:0003124)	3.39370920
46	Abnormality of the intrinsic pathway (HP:0010989)	3.37526665
47	Abnormality of complement system (HP:0005339)	3.33789062
48	Increased serum pyruvate (HP:0003542)	3.33120740
49	Progressive macrocephaly (HP:0004481)	3.32462954
50	Delayed CNS myelination (HP:0002188)	3.27328865
51	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.26574658
52	Dicarboxylic aciduria (HP:0003215)	3.26574658
53	Macrocytic anemia (HP:0001972)	3.25750043
54	Ragged-red muscle fibers (HP:0003200)	3.22911091
55	Hyperbilirubinemia (HP:0002904)	3.18897717
56	Cerebral edema (HP:0002181)	3.16050342
57	Lethargy (HP:0001254)	3.11569715
58	Abnormality of nucleobase metabolism (HP:0010932)	3.06392077
59	Metabolic acidosis (HP:0001942)	3.05247032
60	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.04658741
61	Cerebral palsy (HP:0100021)	3.00530920
62	Conjugated hyperbilirubinemia (HP:0002908)	2.99516002
63	Abnormality of glycolysis (HP:0004366)	2.94960535
64	Hyperthyroidism (HP:0000836)	2.90299475
65	Lactic acidosis (HP:0003128)	2.88653499
66	Renal Fanconi syndrome (HP:0001994)	2.85845424
67	Gout (HP:0001997)	2.82450395
68	Steatorrhea (HP:0002570)	2.79590056
69	Pallor (HP:0000980)	2.76972888
70	Microvesicular hepatic steatosis (HP:0001414)	2.76470780
71	Exercise intolerance (HP:0003546)	2.76237650
72	Abnormality of purine metabolism (HP:0004352)	2.75697815
73	Impulsivity (HP:0100710)	2.75012805
74	Hepatocellular carcinoma (HP:0001402)	2.72078572
75	Skin nodule (HP:0200036)	2.67135085
76	Abnormality of reticulocytes (HP:0004312)	2.63707427
77	Myocardial infarction (HP:0001658)	2.63475004
78	Increased serum lactate (HP:0002151)	2.62179184
79	Lipid accumulation in hepatocytes (HP:0006561)	2.61883420
80	Spontaneous abortion (HP:0005268)	2.61556794
81	Hypochromic microcytic anemia (HP:0004840)	2.52419393
82	Generalized aminoaciduria (HP:0002909)	2.51387848
83	Vascular calcification (HP:0004934)	2.45385379
84	Vomiting (HP:0002013)	2.45051337
85	Abnormal gallbladder morphology (HP:0012437)	2.41840253
86	Cholelithiasis (HP:0001081)	2.41293236
87	Reduced antithrombin III activity (HP:0001976)	2.39950790
88	Irritability (HP:0000737)	2.36065858
89	Increased hepatocellular lipid droplets (HP:0006565)	2.35106038
90	Microretrognathia (HP:0000308)	2.35008259
91	Spastic diplegia (HP:0001264)	2.34019480
92	Hyperphosphaturia (HP:0003109)	2.33910605
93	Systemic lupus erythematosus (HP:0002725)	2.32700684
94	Hypoglycemic seizures (HP:0002173)	2.30878896
95	3-Methylglutaconic aciduria (HP:0003535)	2.28865692
96	Neonatal onset (HP:0003623)	2.25513545
97	Late onset (HP:0003584)	2.25342529
98	Respiratory failure (HP:0002878)	2.24940174
99	Malnutrition (HP:0004395)	2.19835943
100	Rhabdomyolysis (HP:0003201)	2.18440137
101	Acanthocytosis (HP:0001927)	2.17892284
102	Cardiovascular calcification (HP:0011915)	2.15282346
103	Brushfield spots (HP:0001088)	2.14893997
104	Hyperinsulinemic hypoglycemia (HP:0000825)	2.14370666
105	Pancreatitis (HP:0001733)	2.13264406
106	Proximal tubulopathy (HP:0000114)	2.12237676
107	Myokymia (HP:0002411)	2.11249200
108	Chromsome breakage (HP:0040012)	2.10694559
109	Cholecystitis (HP:0001082)	2.07315628
110	Abnormal gallbladder physiology (HP:0012438)	2.07315628
111	Amyloidosis (HP:0011034)	2.06904551
112	Myoglobinuria (HP:0002913)	2.06099823
113	Renal cortical cysts (HP:0000803)	2.05046406
114	Abnormality of the Achilles tendon (HP:0005109)	2.04846641
115	Nausea (HP:0002018)	2.04665621
116	Abnormal glycosylation (HP:0012345)	2.03238641
117	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.03238641
118	Abnormal protein N-linked glycosylation (HP:0012347)	2.03238641
119	Abnormal protein glycosylation (HP:0012346)	2.03238641
120	Esophageal varix (HP:0002040)	2.02353484
121	Acute encephalopathy (HP:0006846)	2.02312324
122	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.01646476
123	Sensorimotor neuropathy (HP:0007141)	2.01606252
124	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.01562250
125	Glomerulonephritis (HP:0000099)	2.00387085
126	Mitral stenosis (HP:0001718)	1.99767669
127	Opisthotonus (HP:0002179)	1.99481069
128	Increased purine levels (HP:0004368)	1.99434116
129	Hyperuricemia (HP:0002149)	1.99434116
130	Enlarged kidneys (HP:0000105)	1.98707466
131	Abnormal cartilage morphology (HP:0002763)	1.98294748
132	Progressive muscle weakness (HP:0003323)	1.98287864
133	Hepatic necrosis (HP:0002605)	1.96388315
134	Abnormal urine phosphate concentration (HP:0012599)	1.96344450
135	Abnormality of iron homeostasis (HP:0011031)	1.95386708
136	Seborrheic dermatitis (HP:0001051)	1.94976009
137	Abnormality of transition element cation homeostasis (HP:0011030)	1.93511177
138	Abnormality of urine glucose concentration (HP:0011016)	1.93099737
139	Glycosuria (HP:0003076)	1.93099737
140	Hydroxyprolinuria (HP:0003080)	1.90250169
141	Abnormality of proline metabolism (HP:0010907)	1.90250169
142	Abnormality of the gallbladder (HP:0005264)	1.90231573
143	CNS demyelination (HP:0007305)	1.89332292
144	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.87920529
145	Poikilocytosis (HP:0004447)	1.86702943
146	Type I transferrin isoform profile (HP:0003642)	1.86297919
147	Thrombophlebitis (HP:0004418)	1.84575227
148	Alkalosis (HP:0001948)	1.84167241
149	Hyperglycemia (HP:0003074)	1.83610695
150	Abnormality of vitamin metabolism (HP:0100508)	1.83472999
151	Tubulointerstitial nephritis (HP:0001970)	1.82094774
152	Reticulocytosis (HP:0001923)	1.81593879
153	Truncus arteriosus (HP:0001660)	1.81049604
154	Broad distal phalanx of finger (HP:0009836)	1.80730462
155	Elevated hepatic transaminases (HP:0002910)	1.79478938
156	Leukodystrophy (HP:0002415)	1.78582548
157	Emotional lability (HP:0000712)	1.78185188
158	Hypertensive crisis (HP:0100735)	1.77389342
159	Pancytopenia (HP:0001876)	1.75919514
160	Achilles tendon contracture (HP:0001771)	1.74164396

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	8.35850405
2	SIK1	4.14908374
3	FGFR4	3.82681273
4	ERN1	3.64968655
5	VRK2	3.61337794
6	CDC7	3.20610086
7	STK16	3.01671486
8	SCYL2	2.84144808
9	TESK2	2.68273195
10	PIM2	2.60736626
11	ARAF	2.56276231
12	PKN2	2.38000477
13	TRIB3	2.37333882
14	LIMK1	2.29275662
15	INSRR	2.28356071
16	TESK1	2.25098074
17	ERBB4	2.25082043
18	PINK1	2.16037119
19	CDK8	2.13498561
20	TAOK3	2.03583922
21	MAPK11	1.91776818
22	FLT3	1.89568732
23	PDK3	1.79018905
24	PDK4	1.79018905
25	MAP2K4	1.75564548
26	TLK1	1.68815255
27	SRPK1	1.68346044
28	AURKA	1.60411187
29	PIK3CG	1.60015834
30	MST1R	1.55981206
31	VRK1	1.52700521
32	LRRK2	1.49147694
33	STK38L	1.46530702
34	LATS1	1.46499277
35	ABL2	1.45229546
36	KDR	1.42695930
37	NEK9	1.36210478
38	TYK2	1.35861948
39	DYRK2	1.35685055
40	CCNB1	1.33508967
41	BUB1	1.33062209
42	SMG1	1.32787879
43	MAP2K3	1.27978670
44	TTN	1.27115844
45	PRKAA2	1.26386431
46	DYRK3	1.24845437
47	ZAK	1.24136262
48	NEK1	1.20992485
49	NME2	1.18881616
50	PLK4	1.18770825
51	MAPK12	1.18770158
52	OBSCN	1.16862916
53	EPHB2	1.15516497
54	ATR	1.14465328
55	MAP3K7	1.14309746
56	BRAF	1.13772337
57	TIE1	1.13764525
58	PHKG1	1.12638788
59	PHKG2	1.12638788
60	DAPK1	1.12240236
61	EIF2AK1	1.11684613
62	NME1	1.08091994
63	CDK7	1.06069018
64	DAPK2	1.05578273
65	CHEK2	1.04268520
66	PTK6	1.03284678
67	JAK2	1.03201887
68	GRK6	1.02464092
69	AURKB	1.02410345
70	PDK2	1.00072587
71	MYLK	0.99261701
72	MAP3K3	0.95897037
73	ILK	0.94856091
74	PLK1	0.92946440
75	PRKAA1	0.92872004
76	RPS6KA5	0.91306712
77	MAPK4	0.90655854
78	LMTK2	0.90565093
79	MAP3K11	0.88227934
80	CSNK1G3	0.86552468
81	CSNK2A2	0.81871689
82	CAMK2G	0.80210371
83	FGFR2	0.78768631
84	NUAK1	0.78330595
85	PRKACG	0.77542803
86	MINK1	0.74209387
87	RPS6KB2	0.73776624
88	MAP2K6	0.72376069
89	BRSK1	0.71182615
90	CSNK2A1	0.70126086
91	TAOK2	0.69394143
92	MET	0.68979743
93	DAPK3	0.68451174
94	PRKCZ	0.68374635
95	PIK3CA	0.67934076
96	MAPK15	0.66948880
97	TBK1	0.66568436
98	EPHB1	0.66411700
99	MAP2K7	0.66408900
100	MAP3K10	0.65621245
101	ERBB2	0.64621425
102	CDK6	0.63761953
103	GSK3A	0.62884159
104	CSNK1G2	0.61251823
105	CDK4	0.60721475
106	MAP3K8	0.60406697
107	JAK1	0.60299512
108	IRAK3	0.60083643
109	RPS6KA4	0.58082149
110	FRK	0.57480746
111	MAP3K5	0.55587071
112	WEE1	0.55364151
113	CHEK1	0.55312412
114	RPS6KC1	0.54631173
115	RPS6KL1	0.54631173
116	PRKCI	0.53048746
117	CDK14	0.52726934
118	MAPK7	0.52137114
119	SGK3	0.51483869
120	PDPK1	0.50770808
121	CSNK1A1L	0.50699853
122	CDK2	0.50116629
123	PBK	0.50033850
124	DYRK1B	0.49828230
125	CDK11A	0.49693816
126	CAMK2D	0.48828448
127	CDK15	0.47619260
128	RPS6KA6	0.46955232
129	PAK1	0.46533953
130	RAF1	0.46389937
131	PAK3	0.45734601
132	TGFBR2	0.45435011
133	MAP3K6	0.43628063
134	CSK	0.42708872
135	TAF1	0.40649323
136	LATS2	0.40528193
137	PKN1	0.40077859
138	MTOR	0.38591786
139	DMPK	0.38584845
140	SGK2	0.38145741
141	CDK18	0.37001682
142	CAMK1D	0.37000266
143	CDK9	0.36614222
144	PIM1	0.36005473
145	CAMK4	0.35457777
146	WNK4	0.35423739
147	CSF1R	0.34988940
148	PRKD1	0.33783075
149	PRKCQ	0.33649479
150	SGK223	0.33535159
151	SGK494	0.33535159
152	PRKCD	0.33505802
153	ICK	0.33428094
154	GRK1	0.32703283
155	CSNK1A1	0.32441816
156	PRKACB	0.32169225
157	RPS6KA2	0.32083052
158	ATM	0.31573565
159	MAPKAPK3	0.31190105
160	IGF1R	0.28410158
161	MAP2K1	0.28163677
162	AKT2	0.27721655
163	STK4	0.27259363
164	PTK2	0.26601116
165	PDK1	0.26508174
166	EPHA2	0.26178780
167	PRKACA	0.26101648
168	CSNK1G1	0.24572485
169	MAP2K2	0.23341761
170	MAP3K14	0.23279447
171	EPHA3	0.22873911

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.14448747
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.39104175
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.36733210
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.09937120
5	Ribosome_Homo sapiens_hsa03010	2.98716174
6	Arginine biosynthesis_Homo sapiens_hsa00220	2.96456040
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.82417462
8	Fatty acid degradation_Homo sapiens_hsa00071	2.71907585
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.65111410
10	DNA replication_Homo sapiens_hsa03030	2.63932891
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.61283403
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.58259617
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.57688008
14	Complement and coagulation cascades_Homo sapiens_hsa04610	2.43744335
15	Propanoate metabolism_Homo sapiens_hsa00640	2.34120418
16	Butanoate metabolism_Homo sapiens_hsa00650	2.22183288
17	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.16092568
18	* Peroxisome_Homo sapiens_hsa04146	2.09597651
19	Base excision repair_Homo sapiens_hsa03410	2.05443744
20	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.03305691
21	Fatty acid metabolism_Homo sapiens_hsa01212	2.00266660
22	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.99567654
23	PPAR signaling pathway_Homo sapiens_hsa03320	1.94376439
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.84639219
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.84604207
26	beta-Alanine metabolism_Homo sapiens_hsa00410	1.75858264
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.73991277
28	Histidine metabolism_Homo sapiens_hsa00340	1.73656973
29	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.72385037
30	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.69522684
31	Mismatch repair_Homo sapiens_hsa03430	1.66402301
32	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.64030856
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.61657192
34	Caffeine metabolism_Homo sapiens_hsa00232	1.60718830
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.58200787
36	Retinol metabolism_Homo sapiens_hsa00830	1.57382917
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.56618662
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.54148407
39	Phenylalanine metabolism_Homo sapiens_hsa00360	1.49690868
40	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.47070630
41	Carbon metabolism_Homo sapiens_hsa01200	1.43464559
42	Fatty acid elongation_Homo sapiens_hsa00062	1.41825060
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.41312569
44	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.38258832
45	Tyrosine metabolism_Homo sapiens_hsa00350	1.36637591
46	Bile secretion_Homo sapiens_hsa04976	1.35873106
47	Sulfur metabolism_Homo sapiens_hsa00920	1.31808735
48	Folate biosynthesis_Homo sapiens_hsa00790	1.30072908
49	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.26995358
50	Homologous recombination_Homo sapiens_hsa03440	1.23742454
51	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.14220506
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.12703653
53	Fat digestion and absorption_Homo sapiens_hsa04975	1.12149510
54	Arginine and proline metabolism_Homo sapiens_hsa00330	1.12007338
55	Sulfur relay system_Homo sapiens_hsa04122	1.07008791
56	Steroid biosynthesis_Homo sapiens_hsa00100	1.06456676
57	ABC transporters_Homo sapiens_hsa02010	1.04649924
58	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.99643399
59	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.99536168
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.99408551
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.97562832
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.90035360
63	Proteasome_Homo sapiens_hsa03050	0.89810238
64	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89230059
65	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.88368226
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88345025
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.85643761
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.85531025
69	RNA polymerase_Homo sapiens_hsa03020	0.84874270
70	One carbon pool by folate_Homo sapiens_hsa00670	0.80176849
71	Lysine degradation_Homo sapiens_hsa00310	0.78972032
72	Glutathione metabolism_Homo sapiens_hsa00480	0.77029046
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.76766450
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71461352
75	Pentose phosphate pathway_Homo sapiens_hsa00030	0.70418730
76	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.69393074
77	Metabolic pathways_Homo sapiens_hsa01100	0.56362573
78	Spliceosome_Homo sapiens_hsa03040	0.56106262
79	Purine metabolism_Homo sapiens_hsa00230	0.53540160
80	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.40205286
81	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.39791329
82	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.39625068
83	Cell cycle_Homo sapiens_hsa04110	0.38807499
84	Galactose metabolism_Homo sapiens_hsa00052	0.35797553
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.33362241
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.31553523
87	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.31032320
88	Linoleic acid metabolism_Homo sapiens_hsa00591	0.29135220
89	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.26763760
90	Insulin resistance_Homo sapiens_hsa04931	0.24639201
91	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.24006576
92	Prion diseases_Homo sapiens_hsa05020	0.22619881
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.21867048
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.20213267
95	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.17389764
96	RNA transport_Homo sapiens_hsa03013	0.16817499
97	Oxidative phosphorylation_Homo sapiens_hsa00190	0.13837432
98	Alcoholism_Homo sapiens_hsa05034	0.12402653
99	Glucagon signaling pathway_Homo sapiens_hsa04922	0.11238457
100	Parkinsons disease_Homo sapiens_hsa05012	0.10920922
101	Protein export_Homo sapiens_hsa03060	0.09231548
102	Non-homologous end-joining_Homo sapiens_hsa03450	0.07098821
103	AMPK signaling pathway_Homo sapiens_hsa04152	0.07030023
104	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.01784168
105	Circadian rhythm_Homo sapiens_hsa04710	-0.2483152
106	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.2395401
107	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	-0.2271989
108	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.2160100
109	Ether lipid metabolism_Homo sapiens_hsa00565	-0.2089728
110	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	-0.2059029
111	Renin-angiotensin system_Homo sapiens_hsa04614	-0.1803612
112	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.1772460
113	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1494183
114	Pyrimidine metabolism_Homo sapiens_hsa00240	-0.1492009
115	Cardiac muscle contraction_Homo sapiens_hsa04260	-0.1416646
116	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.1292472
117	Huntingtons disease_Homo sapiens_hsa05016	-0.1033097
118	Regulation of autophagy_Homo sapiens_hsa04140	-0.0595235
119	Insulin signaling pathway_Homo sapiens_hsa04910	-0.0571787
120	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.0371794
121	Alzheimers disease_Homo sapiens_hsa05010	-0.0271183

PXMP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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