ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.01096454
2	L-phenylalanine catabolic process (GO:0006559)	7.01096454
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.65834824
4	L-phenylalanine metabolic process (GO:0006558)	6.65834824
5	aromatic amino acid family catabolic process (GO:0009074)	6.23643876
6	indole-containing compound catabolic process (GO:0042436)	5.57633144
7	indolalkylamine catabolic process (GO:0046218)	5.57633144
8	tryptophan catabolic process (GO:0006569)	5.57633144
9	glyoxylate metabolic process (GO:0046487)	5.37620800
10	bile acid biosynthetic process (GO:0006699)	5.26528845
11	tryptophan metabolic process (GO:0006568)	5.23227433
12	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.15601051
13	behavioral response to nicotine (GO:0035095)	5.14848193
14	kynurenine metabolic process (GO:0070189)	5.04746117
15	alpha-linolenic acid metabolic process (GO:0036109)	4.94370828
16	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.89052540
17	cysteine metabolic process (GO:0006534)	4.84407442
18	regulation of hippo signaling (GO:0035330)	4.71742440
19	sulfur amino acid catabolic process (GO:0000098)	4.59866748
20	aromatic amino acid family metabolic process (GO:0009072)	4.57146734
21	regulation of triglyceride catabolic process (GO:0010896)	4.52261189
22	bile acid metabolic process (GO:0008206)	4.44787269
23	cellular ketone body metabolic process (GO:0046950)	4.44476609
24	high-density lipoprotein particle remodeling (GO:0034375)	4.40230270
25	tyrosine metabolic process (GO:0006570)	4.39877058
26	complement activation, alternative pathway (GO:0006957)	4.38833248
27	serine family amino acid catabolic process (GO:0009071)	4.38739763
28	regulation of fibrinolysis (GO:0051917)	4.34788554
29	protein carboxylation (GO:0018214)	4.32469102
30	peptidyl-glutamic acid carboxylation (GO:0017187)	4.32469102
31	urea cycle (GO:0000050)	4.29195118
32	urea metabolic process (GO:0019627)	4.29195118
33	amino-acid betaine metabolic process (GO:0006577)	4.26607738
34	cellular biogenic amine catabolic process (GO:0042402)	4.21639971
35	amine catabolic process (GO:0009310)	4.21639971
36	negative regulation of fibrinolysis (GO:0051918)	4.18948693
37	regulation of cholesterol esterification (GO:0010872)	4.17564841
38	regulation of protein activation cascade (GO:2000257)	4.16549945
39	nitrogen cycle metabolic process (GO:0071941)	4.14253407
40	alpha-amino acid catabolic process (GO:1901606)	4.13125935
41	acylglycerol homeostasis (GO:0055090)	4.12554874
42	triglyceride homeostasis (GO:0070328)	4.12554874
43	indolalkylamine metabolic process (GO:0006586)	4.08046408
44	L-fucose catabolic process (GO:0042355)	4.05946178
45	fucose catabolic process (GO:0019317)	4.05946178
46	L-fucose metabolic process (GO:0042354)	4.05946178
47	homocysteine metabolic process (GO:0050667)	4.02150092
48	short-chain fatty acid metabolic process (GO:0046459)	4.01729873
49	aldehyde catabolic process (GO:0046185)	3.99249131
50	coenzyme catabolic process (GO:0009109)	3.96849491
51	lysine metabolic process (GO:0006553)	3.96768891
52	lysine catabolic process (GO:0006554)	3.96768891
53	fatty acid elongation (GO:0030497)	3.93797624
54	plasma lipoprotein particle remodeling (GO:0034369)	3.91169872
55	protein-lipid complex remodeling (GO:0034368)	3.91169872
56	macromolecular complex remodeling (GO:0034367)	3.91169872
57	DNA deamination (GO:0045006)	3.88727272
58	drug transmembrane transport (GO:0006855)	3.88620157
59	ethanol oxidation (GO:0006069)	3.88427929
60	reverse cholesterol transport (GO:0043691)	3.87050814
61	regulation of complement activation (GO:0030449)	3.87017233
62	cellular amino acid catabolic process (GO:0009063)	3.85748675
63	phospholipid efflux (GO:0033700)	3.85665747
64	fatty acid beta-oxidation (GO:0006635)	3.85195437
65	very long-chain fatty acid metabolic process (GO:0000038)	3.85138515
66	ketone body metabolic process (GO:1902224)	3.82720753
67	cellular glucuronidation (GO:0052695)	3.78308487
68	plasma lipoprotein particle clearance (GO:0034381)	3.77687492
69	fatty acid oxidation (GO:0019395)	3.75961150
70	acetyl-CoA metabolic process (GO:0006084)	3.75621832
71	urate metabolic process (GO:0046415)	3.74045438
72	serine family amino acid metabolic process (GO:0009069)	3.72329832
73	bile acid and bile salt transport (GO:0015721)	3.70993920
74	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.70826379
75	fatty acid catabolic process (GO:0009062)	3.70784210
76	benzene-containing compound metabolic process (GO:0042537)	3.69732922
77	lipid oxidation (GO:0034440)	3.69349632
78	carboxylic acid catabolic process (GO:0046395)	3.65534654
79	organic acid catabolic process (GO:0016054)	3.65534654
80	serine family amino acid biosynthetic process (GO:0009070)	3.64070985
81	monocarboxylic acid catabolic process (GO:0072329)	3.63831600
82	signal peptide processing (GO:0006465)	3.63340557
83	NAD biosynthetic process (GO:0009435)	3.61917746
84	positive regulation of lipoprotein lipase activity (GO:0051006)	3.60988851
85	positive regulation of triglyceride lipase activity (GO:0061365)	3.60988851
86	heme transport (GO:0015886)	3.58663255
87	uronic acid metabolic process (GO:0006063)	3.57488604
88	glucuronate metabolic process (GO:0019585)	3.57488604
89	drug catabolic process (GO:0042737)	3.53636520
90	preassembly of GPI anchor in ER membrane (GO:0016254)	3.53624157
91	glutamate metabolic process (GO:0006536)	3.53467145
92	imidazole-containing compound metabolic process (GO:0052803)	3.53071702
93	cofactor catabolic process (GO:0051187)	3.52245993
94	branched-chain amino acid catabolic process (GO:0009083)	3.52012668
95	pyridine nucleotide biosynthetic process (GO:0019363)	3.49494017
96	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.49494017
97	cholesterol efflux (GO:0033344)	3.48757808
98	negative regulation of cholesterol transport (GO:0032375)	3.46878654
99	negative regulation of sterol transport (GO:0032372)	3.46878654
100	negative regulation of lipase activity (GO:0060192)	3.45234249
101	cellular modified amino acid catabolic process (GO:0042219)	3.44576958
102	neuronal action potential (GO:0019228)	3.43263335
103	low-density lipoprotein particle remodeling (GO:0034374)	3.41701354
104	blood coagulation, intrinsic pathway (GO:0007597)	3.40925007
105	glycine metabolic process (GO:0006544)	3.39271940
106	fibrinolysis (GO:0042730)	3.36633020
107	opsonization (GO:0008228)	3.35718301
108	regulation of bile acid biosynthetic process (GO:0070857)	3.34352265
109	carnitine metabolic process (GO:0009437)	3.33314186
110	very-low-density lipoprotein particle assembly (GO:0034379)	3.32913835
111	response to pheromone (GO:0019236)	3.29566057
112	indole-containing compound metabolic process (GO:0042430)	3.24916945
113	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.24870307
114	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.16947899
115	axoneme assembly (GO:0035082)	3.14838215
116	detection of light stimulus involved in sensory perception (GO:0050962)	3.09254672
117	detection of light stimulus involved in visual perception (GO:0050908)	3.09254672
118	protein complex biogenesis (GO:0070271)	3.08885346
119	cornea development in camera-type eye (GO:0061303)	3.08720123
120	peristalsis (GO:0030432)	3.06126659
121	sulfation (GO:0051923)	3.05665504
122	mannosylation (GO:0097502)	3.04748866
123	multicellular organism reproduction (GO:0032504)	3.03767083
124	prostate gland growth (GO:0060736)	3.02364076
125	phasic smooth muscle contraction (GO:0014821)	3.01527648
126	water-soluble vitamin biosynthetic process (GO:0042364)	2.92919360
127	neural tube formation (GO:0001841)	2.91906484
128	protein polyglutamylation (GO:0018095)	2.90410204
129	piRNA metabolic process (GO:0034587)	2.89303933
130	urinary tract smooth muscle contraction (GO:0014848)	2.86787609
131	serotonin metabolic process (GO:0042428)	2.86069046
132	respiratory chain complex IV assembly (GO:0008535)	2.83949258
133	regulation of action potential (GO:0098900)	2.81622650
134	negative regulation of telomere maintenance (GO:0032205)	2.81461758
135	cellular response to ATP (GO:0071318)	2.80424140
136	primary amino compound metabolic process (GO:1901160)	2.78473706
137	mitochondrial respiratory chain complex assembly (GO:0033108)	2.77901943
138	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.77573087
139	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.77011281
140	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.76651593
141	NADH dehydrogenase complex assembly (GO:0010257)	2.76651593
142	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.76651593
143	oxidative demethylation (GO:0070989)	2.76219534
144	S-adenosylmethionine metabolic process (GO:0046500)	2.76107311
145	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.75201771
146	ubiquinone biosynthetic process (GO:0006744)	2.73087739
147	thyroid hormone metabolic process (GO:0042403)	2.72829154
148	reflex (GO:0060004)	2.71736057
149	cytochrome complex assembly (GO:0017004)	2.71040213
150	photoreceptor cell maintenance (GO:0045494)	2.70505163
151	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.70482708
152	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.70482708
153	behavioral response to ethanol (GO:0048149)	2.70187675
154	GPI anchor metabolic process (GO:0006505)	2.69290321
155	flavonoid metabolic process (GO:0009812)	2.66492720
156	gamma-aminobutyric acid transport (GO:0015812)	2.66212177
157	platelet dense granule organization (GO:0060155)	2.65380592
158	epithelial cilium movement (GO:0003351)	2.62057540
159	embryonic epithelial tube formation (GO:0001838)	2.60864100
160	positive regulation of fatty acid transport (GO:2000193)	2.60073780
161	C-terminal protein lipidation (GO:0006501)	2.58162629
162	phenylpropanoid metabolic process (GO:0009698)	2.58071950
163	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.54464624
164	parturition (GO:0007567)	2.45328825
165	DNA methylation involved in gamete generation (GO:0043046)	2.45063559
166	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.44651177
167	sphingoid metabolic process (GO:0046519)	2.43764356
168	ubiquinone metabolic process (GO:0006743)	2.43465191
169	C-terminal protein amino acid modification (GO:0018410)	2.42680673
170	rhodopsin mediated signaling pathway (GO:0016056)	2.41718924
171	cilium organization (GO:0044782)	2.41177522
172	keratinocyte development (GO:0003334)	2.41108203
173	auditory receptor cell stereocilium organization (GO:0060088)	2.40962780
174	cilium or flagellum-dependent cell motility (GO:0001539)	2.40458605
175	nucleotide transmembrane transport (GO:1901679)	2.39580206
176	xenobiotic catabolic process (GO:0042178)	2.38913136
177	nonmotile primary cilium assembly (GO:0035058)	2.37681065
178	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.37597918
179	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.37588161
180	cilium morphogenesis (GO:0060271)	2.37479738
181	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.37359492
182	cilium movement (GO:0003341)	2.36817788
183	valine metabolic process (GO:0006573)	2.36629968
184	negative regulation of systemic arterial blood pressure (GO:0003085)	2.36521278
185	L-methionine biosynthetic process (GO:0071265)	2.35466567

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	9.69236063
2	* RXR_22158963_ChIP-Seq_LIVER_Mouse	6.83733490
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.43216252
4	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.74085839
5	* LXR_22158963_ChIP-Seq_LIVER_Mouse	5.32361020
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	5.12826539
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.57744187
8	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.47541324
9	ZNF274_21170338_ChIP-Seq_K562_Hela	3.90076048
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.50399874
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.44184421
12	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.03984063
13	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.78607681
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20627240
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.08330439
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.02825176
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.01882126
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98622872
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.89968117
20	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.86422475
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.85822168
22	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84368558
23	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.83833238
24	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.83632808
25	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.79218839
26	HTT_18923047_ChIP-ChIP_STHdh_Human	1.75898918
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.73132586
28	FUS_26573619_Chip-Seq_HEK293_Human	1.72489590
29	P300_19829295_ChIP-Seq_ESCs_Human	1.68967783
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.65598749
31	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.65242177
32	EWS_26573619_Chip-Seq_HEK293_Human	1.65144273
33	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.64158508
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.60266759
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.52764465
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.52764465
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.51773217
38	AHR_22903824_ChIP-Seq_MCF-7_Human	1.51647253
39	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.50972624
40	AR_25329375_ChIP-Seq_VCAP_Human	1.50882104
41	STAT3_23295773_ChIP-Seq_U87_Human	1.50710187
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48376400
43	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.47745039
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.45104027
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42590058
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.42590058
47	* HOXB7_26014856_ChIP-Seq_BT474_Human	1.39365303
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.39353905
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.39041898
50	TCF4_23295773_ChIP-Seq_U87_Human	1.38900717
51	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.38811628
52	GATA1_22025678_ChIP-Seq_K562_Human	1.35935284
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35296661
54	SMAD4_21799915_ChIP-Seq_A2780_Human	1.35135464
55	NCOR_22424771_ChIP-Seq_293T_Human	1.35089012
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.34005232
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32917192
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32615107
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29220046
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.29167944
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26584657
62	TAF15_26573619_Chip-Seq_HEK293_Human	1.26276009
63	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.25399103
64	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22876912
65	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22876912
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22832544
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21308000
68	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.20371908
69	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19526454
70	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19461728
71	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18502541
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16894457
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16785291
74	REST_21632747_ChIP-Seq_MESCs_Mouse	1.16324494
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14806569
76	AR_21572438_ChIP-Seq_LNCaP_Human	1.14727565
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14625755
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.13463747
79	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13193148
80	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.12869312
81	ERA_21632823_ChIP-Seq_H3396_Human	1.12854471
82	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.12354252
83	MYC_18940864_ChIP-ChIP_HL60_Human	1.11958094
84	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.11337143
85	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.10878557
86	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.09501127
87	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.07454040
88	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.06876079
89	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.04308241
90	P53_21459846_ChIP-Seq_SAOS-2_Human	1.02288641
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02165387
92	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.02089760
93	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01839116
94	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.01061923
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99900605
96	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.97255242
97	* NANOG_20526341_ChIP-Seq_ESCs_Human	0.95271793
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94853664
99	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.94702009
100	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.94591055
101	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94376626
102	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.93664029
103	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93614951
104	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.93532602
105	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.93510133
106	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.92883402
107	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92453394
108	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.90049505
109	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.89641126
110	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.88667472
111	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.88667472
112	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.88037743
113	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.85953782
114	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.85794577
115	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.85766979
116	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.85345461
117	GATA4_25053715_ChIP-Seq_YYC3_Human	0.85113826
118	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.84483295
119	AR_20517297_ChIP-Seq_VCAP_Human	0.82291489
120	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.82047311
121	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.80334951
122	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.80171964
123	CLOCK_20551151_ChIP-Seq_293T_Human	0.80092018
124	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.79910065
125	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.79760741
126	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.79621934
127	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.79581026
128	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.79238758
129	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.78056299
130	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.77873405
131	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.77042748
132	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.76811982
133	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.76739057
134	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.76497187
135	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.76307397
136	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.75391297
137	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.73748278
138	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.72835084
139	GBX2_23144817_ChIP-Seq_PC3_Human	0.72627159
140	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.71770878
141	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.71225144
142	STAT1_17558387_ChIP-Seq_HELA_Human	0.70948264
143	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.69584763
144	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.68486071
145	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.67931004
146	CEBPB_22108803_ChIP-Seq_LS180_Human	0.66470928
147	SOX2_20726797_ChIP-Seq_SW620_Human	0.66461323
148	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.66384734
149	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.65397664
150	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.65165959
151	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.64919296
152	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.64853724
153	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.64530051
154	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.64009543
155	CBP_21632823_ChIP-Seq_H3396_Human	0.63900766
156	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.63668088
157	EGR1_19032775_ChIP-ChIP_M12_Human	0.63175169
158	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.62126958
159	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.61455202
160	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.61183115
161	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.60728952
162	SOX2_19829295_ChIP-Seq_ESCs_Human	0.60441155
163	NANOG_19829295_ChIP-Seq_ESCs_Human	0.60441155
164	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.60276123
165	VDR_22108803_ChIP-Seq_LS180_Human	0.59891920
166	* PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.59528619
167	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.59205928
168	ERG_20517297_ChIP-Seq_VCAP_Human	0.58685907
169	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.58203765
170	P300_18555785_Chip-Seq_ESCs_Mouse	0.57536062
171	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.57337467
172	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.57140476
173	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.56550654
174	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.56207639
175	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.56163051

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.47134630
2	MP0005360_urolithiasis	6.85190691
3	MP0005085_abnormal_gallbladder_physiolo	5.63611180
4	MP0005365_abnormal_bile_salt	5.37711381
5	MP0008875_abnormal_xenobiotic_pharmacok	4.49890996
6	MP0003806_abnormal_nucleotide_metabolis	4.00258456
7	MP0003252_abnormal_bile_duct	3.42668443
8	MP0003195_calcinosis	3.22918630
9	MP0010329_abnormal_lipoprotein_level	3.10127004
10	MP0000427_abnormal_hair_cycle	3.02616207
11	MP0005332_abnormal_amino_acid	2.85699769
12	MP0005083_abnormal_biliary_tract	2.64505346
13	MP0009840_abnormal_foam_cell	2.64463914
14	MP0004019_abnormal_vitamin_homeostasis	2.61064965
15	MP0005646_abnormal_pituitary_gland	2.50103651
16	MP0005551_abnormal_eye_electrophysiolog	2.43370577
17	MP0001666_abnormal_nutrient_absorption	2.40990301
18	MP0001968_abnormal_touch/_nociception	2.38359700
19	MP0002638_abnormal_pupillary_reflex	2.25982857
20	MP0003191_abnormal_cellular_cholesterol	2.16834814
21	MP0005645_abnormal_hypothalamus_physiol	2.10903921
22	MP0002118_abnormal_lipid_homeostasis	2.07756757
23	MP0008872_abnormal_physiological_respon	1.98048443
24	MP0002653_abnormal_ependyma_morphology	1.94234051
25	MP0003646_muscle_fatigue	1.93336231
26	MP0000372_irregular_coat_pigmentation	1.92662810
27	MP0002138_abnormal_hepatobiliary_system	1.87697479
28	MP0001764_abnormal_homeostasis	1.87373482
29	MP0005451_abnormal_body_composition	1.86062986
30	MP0000609_abnormal_liver_physiology	1.84484207
31	MP0000383_abnormal_hair_follicle	1.80718212
32	MP0005174_abnormal_tail_pigmentation	1.79825963
33	MP0002736_abnormal_nociception_after	1.78679234
34	MP0003186_abnormal_redox_activity	1.76335185
35	MP0003011_delayed_dark_adaptation	1.69819054
36	MP0004885_abnormal_endolymph	1.65360391
37	MP0005319_abnormal_enzyme/_coenzyme	1.62753988
38	MP0009745_abnormal_behavioral_response	1.62377436
39	MP0005584_abnormal_enzyme/coenzyme_acti	1.62286450
40	MP0003868_abnormal_feces_composition	1.60035068
41	MP0004145_abnormal_muscle_electrophysio	1.58195952
42	MP0009643_abnormal_urine_homeostasis	1.54425466
43	MP0002163_abnormal_gland_morphology	1.53761223
44	MP0000647_abnormal_sebaceous_gland	1.53658326
45	MP0000569_abnormal_digit_pigmentation	1.53223840
46	MP0009697_abnormal_copulation	1.52968108
47	MP0009046_muscle_twitch	1.52873639
48	MP0008877_abnormal_DNA_methylation	1.52213623
49	MP0004381_abnormal_hair_follicle	1.50540649
50	MP0002876_abnormal_thyroid_physiology	1.50184002
51	MP0006072_abnormal_retinal_apoptosis	1.49943724
52	MP0000631_abnormal_neuroendocrine_gland	1.48849156
53	MP0001346_abnormal_lacrimal_gland	1.47169327
54	MP0005670_abnormal_white_adipose	1.46283430
55	MP0002938_white_spotting	1.42325823
56	MP0005253_abnormal_eye_physiology	1.38849672
57	MP0006276_abnormal_autonomic_nervous	1.37319956
58	MP0001919_abnormal_reproductive_system	1.37006111
59	MP0010678_abnormal_skin_adnexa	1.35667072
60	MP0003787_abnormal_imprinting	1.35281610
61	MP0005636_abnormal_mineral_homeostasis	1.33185791
62	MP0003045_fibrosis	1.32849173
63	MP0009379_abnormal_foot_pigmentation	1.32498229
64	MP0001485_abnormal_pinna_reflex	1.31032651
65	MP0010386_abnormal_urinary_bladder	1.30535631
66	MP0003724_increased_susceptibility_to	1.30006941
67	MP0005389_reproductive_system_phenotype	1.28745891
68	MP0002102_abnormal_ear_morphology	1.28445930
69	MP0002272_abnormal_nervous_system	1.26681271
70	MP0001501_abnormal_sleep_pattern	1.26678139
71	MP0004142_abnormal_muscle_tone	1.25204307
72	MP0008995_early_reproductive_senescence	1.23893985
73	MP0002095_abnormal_skin_pigmentation	1.23847680
74	MP0009764_decreased_sensitivity_to	1.19464000
75	MP0005084_abnormal_gallbladder_morpholo	1.18510576
76	MP0003656_abnormal_erythrocyte_physiolo	1.16619044
77	MP0004133_heterotaxia	1.15236266
78	MP0005647_abnormal_sex_gland	1.12841288
79	MP0001664_abnormal_digestion	1.12715193
80	MP0009780_abnormal_chondrocyte_physiolo	1.12027194
81	MP0002160_abnormal_reproductive_system	1.11103227
82	MP0006036_abnormal_mitochondrial_physio	1.08854305
83	MP0008057_abnormal_DNA_replication	1.08633402
84	MP0006292_abnormal_olfactory_placode	1.08629570
85	MP0005408_hypopigmentation	1.05269638
86	MP0005310_abnormal_salivary_gland	1.04644951
87	MP0004043_abnormal_pH_regulation	1.02718125
88	MP0001873_stomach_inflammation	1.02606875
89	MP0008775_abnormal_heart_ventricle	1.01714547
90	MP0000566_synostosis	1.00906473
91	MP0002557_abnormal_social/conspecific_i	0.99787434
92	MP0005410_abnormal_fertilization	0.97906778
93	MP0002909_abnormal_adrenal_gland	0.96515121
94	MP0001661_extended_life_span	0.96254450
95	MP0008469_abnormal_protein_level	0.95352552
96	MP0009763_increased_sensitivity_to	0.92997874
97	MP0003878_abnormal_ear_physiology	0.92504878
98	MP0005377_hearing/vestibular/ear_phenot	0.92504878
99	MP0000015_abnormal_ear_pigmentation	0.92305724
100	MP0002733_abnormal_thermal_nociception	0.91875062
101	MP0003690_abnormal_glial_cell	0.91537797
102	MP0001970_abnormal_pain_threshold	0.90667419
103	MP0002572_abnormal_emotion/affect_behav	0.89292682
104	MP0005535_abnormal_body_temperature	0.88184390
105	MP0004147_increased_porphyrin_level	0.86143361
106	MP0002693_abnormal_pancreas_physiology	0.85839837
107	MP0002067_abnormal_sensory_capabilities	0.85473408
108	MP0002751_abnormal_autonomic_nervous	0.85309353
109	MP0002064_seizures	0.84651302
110	MP0009642_abnormal_blood_homeostasis	0.84587650
111	MP0002282_abnormal_trachea_morphology	0.84415746
112	MP0000598_abnormal_liver_morphology	0.83971341
113	MP0004782_abnormal_surfactant_physiolog	0.83678120
114	MP0005334_abnormal_fat_pad	0.83083529
115	MP0001756_abnormal_urination	0.82875209
116	MP0002254_reproductive_system_inflammat	0.82785867
117	MP0005386_behavior/neurological_phenoty	0.82451456
118	MP0004924_abnormal_behavior	0.82451456
119	MP0002971_abnormal_brown_adipose	0.82433566
120	MP0001905_abnormal_dopamine_level	0.82085769
121	MP0001486_abnormal_startle_reflex	0.81847059
122	MP0001502_abnormal_circadian_rhythm	0.81657646
123	MP0009765_abnormal_xenobiotic_induced	0.80692806
124	MP0002277_abnormal_respiratory_mucosa	0.79880266
125	MP0005376_homeostasis/metabolism_phenot	0.79165668
126	MP0008961_abnormal_basal_metabolism	0.78745026
127	MP0005409_darkened_coat_color	0.74671921
128	MP0003718_maternal_effect	0.73415119
129	MP0002796_impaired_skin_barrier	0.73318198
130	MP0002132_abnormal_respiratory_system	0.73279400
131	MP0005075_abnormal_melanosome_morpholog	0.73001039
132	MP0002136_abnormal_kidney_physiology	0.72984599
133	MP0000920_abnormal_myelination	0.71639531
134	MP0005666_abnormal_adipose_tissue	0.68723574
135	MP0002078_abnormal_glucose_homeostasis	0.67984132
136	MP0010368_abnormal_lymphatic_system	0.65384485
137	MP0004130_abnormal_muscle_cell	0.64685242
138	MP0000604_amyloidosis	0.63353960
139	MP0005395_other_phenotype	0.63177135
140	MP0000230_abnormal_systemic_arterial	0.61903784
141	MP0001765_abnormal_ion_homeostasis	0.60007450
142	MP0002837_dystrophic_cardiac_calcinosis	0.59600341
143	MP0005379_endocrine/exocrine_gland_phen	0.58635249
144	MP0005220_abnormal_exocrine_pancreas	0.58193698
145	MP0000579_abnormal_nail_morphology	0.54905288
146	MP0006082_CNS_inflammation	0.53676394
147	MP0005266_abnormal_metabolism	0.53131582
148	MP0002928_abnormal_bile_duct	0.52510932
149	MP0003136_yellow_coat_color	0.51604647
150	MP0001881_abnormal_mammary_gland	0.51553436
151	MP0006035_abnormal_mitochondrial_morpho	0.51273960
152	MP0003638_abnormal_response/metabolism_	0.50963298
153	MP0005448_abnormal_energy_balance	0.50809457
154	MP0001853_heart_inflammation	0.47316076
155	MP0001986_abnormal_taste_sensitivity	0.47264097
156	MP0000639_abnormal_adrenal_gland	0.46138950
157	MP0003959_abnormal_lean_body	0.44409159
158	MP0005058_abnormal_lysosome_morphology	0.44063883
159	MP0009785_altered_susceptibility_to	0.43753180
160	MP0002295_abnormal_pulmonary_circulatio	0.42468940
161	MP0005464_abnormal_platelet_physiology	0.42173801
162	MP0003436_decreased_susceptibility_to	0.41695469
163	MP0002098_abnormal_vibrissa_morphology	0.40561002
164	MP0003953_abnormal_hormone_level	0.40538291
165	MP0002168_other_aberrant_phenotype	0.39345707
166	MP0009384_cardiac_valve_regurgitation	0.39006048
167	MP0005595_abnormal_vascular_smooth	0.37443146
168	MP0000538_abnormal_urinary_bladder	0.36919374
169	MP0002060_abnormal_skin_morphology	0.36498721
170	MP0005164_abnormal_response_to	0.36445091

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.34304265
2	Intrahepatic cholestasis (HP:0001406)	5.91506972
3	Prolonged partial thromboplastin time (HP:0003645)	5.55029739
4	Xanthomatosis (HP:0000991)	5.16754527
5	Deep venous thrombosis (HP:0002625)	5.08733594
6	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.86882817
7	Hyperlipoproteinemia (HP:0010980)	4.64261758
8	Pancreatic cysts (HP:0001737)	4.58792714
9	Hypobetalipoproteinemia (HP:0003563)	4.51516483
10	Hyperglycinuria (HP:0003108)	4.22252750
11	Hyperglycinemia (HP:0002154)	4.14994384
12	Abnormality of serine family amino acid metabolism (HP:0010894)	4.14474249
13	Abnormality of glycine metabolism (HP:0010895)	4.14474249
14	Hyperammonemia (HP:0001987)	4.05948037
15	Joint hemorrhage (HP:0005261)	4.05873435
16	Pancreatic fibrosis (HP:0100732)	4.04017729
17	Complement deficiency (HP:0004431)	4.02677092
18	Congenital stationary night blindness (HP:0007642)	3.98473266
19	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.98459910
20	Ketosis (HP:0001946)	3.94509041
21	True hermaphroditism (HP:0010459)	3.82085244
22	Hypoglycemic coma (HP:0001325)	3.77390765
23	Abnormality of fatty-acid metabolism (HP:0004359)	3.72167157
24	Abnormality of methionine metabolism (HP:0010901)	3.65930780
25	Epidermoid cyst (HP:0200040)	3.64082018
26	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.63618823
27	Molar tooth sign on MRI (HP:0002419)	3.63284568
28	Abnormality of midbrain morphology (HP:0002418)	3.63284568
29	Concave nail (HP:0001598)	3.63007745
30	Abnormality of the renal cortex (HP:0011035)	3.57447085
31	Conjugated hyperbilirubinemia (HP:0002908)	3.52624027
32	Hypolipoproteinemia (HP:0010981)	3.47784178
33	Fat malabsorption (HP:0002630)	3.46363251
34	Type II lissencephaly (HP:0007260)	3.45113266
35	Gaze-evoked nystagmus (HP:0000640)	3.44927497
36	Nephronophthisis (HP:0000090)	3.42293119
37	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.40475262
38	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.39092097
39	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.38713768
40	Abnormality of the common coagulation pathway (HP:0010990)	3.34092273
41	Abnormality of the renal medulla (HP:0100957)	3.24429884
42	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.24321542
43	Abnormality of alanine metabolism (HP:0010916)	3.24321542
44	Hyperalaninemia (HP:0003348)	3.24321542
45	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.22994472
46	Dicarboxylic aciduria (HP:0003215)	3.22994472
47	Decreased circulating renin level (HP:0003351)	3.21727779
48	Hyperventilation (HP:0002883)	3.16572298
49	Hypoalphalipoproteinemia (HP:0003233)	3.16111862
50	Tubular atrophy (HP:0000092)	3.13429480
51	Delayed CNS myelination (HP:0002188)	3.06916959
52	Cerebral edema (HP:0002181)	3.06226869
53	Large for gestational age (HP:0001520)	3.04691336
54	Abolished electroretinogram (ERG) (HP:0000550)	3.03030779
55	Lethargy (HP:0001254)	3.01616123
56	Ketoacidosis (HP:0001993)	2.99449380
57	Abnormality of serum amino acid levels (HP:0003112)	2.98833704
58	Progressive cerebellar ataxia (HP:0002073)	2.92611004
59	Cystic liver disease (HP:0006706)	2.90693972
60	Hyperbilirubinemia (HP:0002904)	2.85270154
61	Generalized aminoaciduria (HP:0002909)	2.85144141
62	Metabolic acidosis (HP:0001942)	2.84903282
63	Abnormality of complement system (HP:0005339)	2.84181645
64	Hypercholesterolemia (HP:0003124)	2.84040129
65	Abnormality of pyrimidine metabolism (HP:0004353)	2.80328862
66	Abnormality of nucleobase metabolism (HP:0010932)	2.78563138
67	Abnormality of purine metabolism (HP:0004352)	2.77680276
68	Steatorrhea (HP:0002570)	2.75720306
69	Proximal tubulopathy (HP:0000114)	2.74351901
70	Abnormality of the intrinsic pathway (HP:0010989)	2.72921604
71	Abnormality of urine glucose concentration (HP:0011016)	2.71768869
72	Glycosuria (HP:0003076)	2.71768869
73	Genetic anticipation (HP:0003743)	2.70538706
74	Furrowed tongue (HP:0000221)	2.66857838
75	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.66453150
76	Attenuation of retinal blood vessels (HP:0007843)	2.65728519
77	Cerebellar dysplasia (HP:0007033)	2.64255633
78	Renal cortical cysts (HP:0000803)	2.60933925
79	Vascular calcification (HP:0004934)	2.55363912
80	Medial flaring of the eyebrow (HP:0010747)	2.52210013
81	Gout (HP:0001997)	2.51214487
82	Acute encephalopathy (HP:0006846)	2.50393363
83	Hepatic necrosis (HP:0002605)	2.48558379
84	Pendular nystagmus (HP:0012043)	2.48539829
85	Keratoconus (HP:0000563)	2.47310103
86	Increased corneal curvature (HP:0100692)	2.47310103
87	Hypoglycemic seizures (HP:0002173)	2.45724679
88	Vomiting (HP:0002013)	2.43894149
89	Enlarged kidneys (HP:0000105)	2.43545390
90	Severe muscular hypotonia (HP:0006829)	2.42392080
91	Polydipsia (HP:0001959)	2.40097935
92	Abnormal drinking behavior (HP:0030082)	2.40097935
93	Spontaneous abortion (HP:0005268)	2.36206353
94	Congenital, generalized hypertrichosis (HP:0004540)	2.34028880
95	Hypoplasia of the pons (HP:0012110)	2.33772767
96	Opisthotonus (HP:0002179)	2.33590936
97	Alkalosis (HP:0001948)	2.33071434
98	Abnormality of the pons (HP:0007361)	2.32567107
99	Clumsiness (HP:0002312)	2.32247612
100	Sclerocornea (HP:0000647)	2.31195226
101	Congenital hepatic fibrosis (HP:0002612)	2.30103450
102	Systemic lupus erythematosus (HP:0002725)	2.27180482
103	Abnormality of macular pigmentation (HP:0008002)	2.26880320
104	Myocardial infarction (HP:0001658)	2.26168042
105	Pancreatitis (HP:0001733)	2.24395083
106	Abnormal rod and cone electroretinograms (HP:0008323)	2.24284755
107	Rickets (HP:0002748)	2.23111334
108	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.23030036
109	Hypophosphatemic rickets (HP:0004912)	2.22160875
110	Hypochromic microcytic anemia (HP:0004840)	2.19458489
111	Inability to walk (HP:0002540)	2.19131743
112	Cardiovascular calcification (HP:0011915)	2.18724477
113	Hepatocellular carcinoma (HP:0001402)	2.17019291
114	Decreased central vision (HP:0007663)	2.16430883
115	Chronic hepatic failure (HP:0100626)	2.15436779
116	Amelogenesis imperfecta (HP:0000705)	2.14853142
117	Amyloidosis (HP:0011034)	2.12953733
118	Renal Fanconi syndrome (HP:0001994)	2.12153287
119	Congenital sensorineural hearing impairment (HP:0008527)	2.11216256
120	Hamartoma of the eye (HP:0010568)	2.08767194
121	Irritability (HP:0000737)	2.08613893
122	Axonal loss (HP:0003447)	2.08484915
123	Male pseudohermaphroditism (HP:0000037)	2.08342329
124	Abnormal biliary tract physiology (HP:0012439)	2.07266541
125	Bile duct proliferation (HP:0001408)	2.07266541
126	Increased muscle lipid content (HP:0009058)	2.06125245
127	Brushfield spots (HP:0001088)	2.03057460
128	Lipid accumulation in hepatocytes (HP:0006561)	2.01174154
129	3-Methylglutaconic aciduria (HP:0003535)	1.99354611
130	Hyperinsulinemic hypoglycemia (HP:0000825)	1.98335051
131	Nausea (HP:0002018)	1.98174078
132	Stomach cancer (HP:0012126)	1.98075703
133	Elevated hepatic transaminases (HP:0002910)	1.96009837
134	Chorioretinal atrophy (HP:0000533)	1.95744373
135	Hyperuricemia (HP:0002149)	1.95236240
136	Increased purine levels (HP:0004368)	1.95236240
137	Skin nodule (HP:0200036)	1.93729905
138	Hyperphosphaturia (HP:0003109)	1.93593121
139	Increased CSF lactate (HP:0002490)	1.93522111
140	Hepatocellular necrosis (HP:0001404)	1.93432506
141	Glomerulonephritis (HP:0000099)	1.92940750
142	Methylmalonic aciduria (HP:0012120)	1.92892690
143	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.92622914
144	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.92305248
145	Progressive inability to walk (HP:0002505)	1.91395967
146	Patellar aplasia (HP:0006443)	1.90664828
147	Gingival bleeding (HP:0000225)	1.90654404
148	Anencephaly (HP:0002323)	1.89858048
149	Protruding tongue (HP:0010808)	1.89577935
150	Tubulointerstitial nephritis (HP:0001970)	1.89079592
151	Parakeratosis (HP:0001036)	1.88978581
152	Abnormality of renin-angiotensin system (HP:0000847)	1.88767397
153	Symptomatic seizures (HP:0011145)	1.88380553
154	Mitochondrial inheritance (HP:0001427)	1.88203314
155	Broad-based gait (HP:0002136)	1.87725711
156	Abnormal protein glycosylation (HP:0012346)	1.87509130
157	Abnormal glycosylation (HP:0012345)	1.87509130
158	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87509130
159	Abnormal protein N-linked glycosylation (HP:0012347)	1.87509130
160	Tinnitus (HP:0000360)	1.87239132
161	Malnutrition (HP:0004395)	1.87119613
162	Aplasia/Hypoplasia of the patella (HP:0006498)	1.86775282
163	Abnormality of vitamin metabolism (HP:0100508)	1.86650384
164	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84701172
165	Abnormal gallbladder morphology (HP:0012437)	1.84301475
166	Gait imbalance (HP:0002141)	1.84055719
167	Tachypnea (HP:0002789)	1.83654107
168	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.83452958
169	Hypertriglyceridemia (HP:0002155)	1.83401932
170	Flat capital femoral epiphysis (HP:0003370)	1.82497573
171	Lactic acidosis (HP:0003128)	1.82424837
172	Conjunctival hamartoma (HP:0100780)	1.81845405
173	Fair hair (HP:0002286)	1.81358444
174	Microretrognathia (HP:0000308)	1.81091908
175	Postaxial foot polydactyly (HP:0001830)	1.81003920
176	Methylmalonic acidemia (HP:0002912)	1.79758956
177	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.79669720
178	Absent/shortened dynein arms (HP:0200106)	1.79669720
179	Abnormality of renal resorption (HP:0011038)	1.79592091
180	Tubulointerstitial fibrosis (HP:0005576)	1.79489182
181	Hydroxyprolinuria (HP:0003080)	1.78697771
182	Abnormality of proline metabolism (HP:0010907)	1.78697771
183	Pili torti (HP:0003777)	1.76738296
184	Congenital primary aphakia (HP:0007707)	1.76018947
185	Lissencephaly (HP:0001339)	1.74175856
186	Hypoplasia of the fovea (HP:0007750)	1.72982858
187	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.72982858
188	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.72564242
189	Hemiparesis (HP:0001269)	1.72112588
190	Generalized hypopigmentation of hair (HP:0011358)	1.71830286
191	Polyuria (HP:0000103)	1.71655940
192	Type I transferrin isoform profile (HP:0003642)	1.70346599
193	Hypoplasia of the uterus (HP:0000013)	1.66388299
194	Acute necrotizing encephalopathy (HP:0006965)	1.64215488

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	5.27370674
2	IRAK3	3.54198722
3	INSRR	3.16738079
4	MAPKAPK3	3.08947191
5	STK16	2.65611997
6	ACVR1B	2.65267018
7	TLK1	2.56081648
8	PIK3CG	2.45038211
9	MAP4K2	2.38101281
10	WNK4	2.25599453
11	SIK1	2.22404361
12	STK39	2.19206596
13	FGFR4	2.18893703
14	OXSR1	2.15594079
15	EPHB1	2.14512701
16	TIE1	2.08205008
17	MST1R	1.88693922
18	PBK	1.87829780
19	ERN1	1.74659118
20	MAPK13	1.72628335
21	IRAK4	1.72091635
22	GRK1	1.69626397
23	ERBB4	1.65369335
24	MAPK15	1.59378389
25	IRAK2	1.58992421
26	IRAK1	1.57510341
27	DAPK2	1.57069555
28	TAOK3	1.52814279
29	NME2	1.48308503
30	WNK3	1.46231281
31	CASK	1.44483860
32	VRK2	1.43847784
33	PKN1	1.43438932
34	KDR	1.39051590
35	ADRBK2	1.36255471
36	FER	1.33959754
37	MAP3K14	1.26813875
38	PRKAA2	1.22407058
39	ABL2	1.19541886
40	MYLK	1.17173374
41	PHKG1	1.16805639
42	PHKG2	1.16805639
43	FRK	1.15674867
44	MAPK11	1.15176736
45	PNCK	1.15033861
46	PRKCI	1.14987584
47	PINK1	1.14827922
48	EPHA2	1.12853566
49	MUSK	1.09708744
50	MAPKAPK5	1.09302919
51	ADRBK1	1.08067192
52	PAK3	1.07310554
53	MET	1.06585682
54	TYK2	1.06392044
55	STK38L	1.05486982
56	RPS6KB2	1.04270617
57	NUAK1	1.04122838
58	FGFR2	1.03472073
59	IKBKE	1.01480732
60	PIK3CA	0.99922218
61	VRK1	0.97555088
62	MST4	0.97131492
63	BRSK2	0.97088723
64	NTRK3	0.94422248
65	ZAK	0.93771681
66	PTK2B	0.93375528
67	NLK	0.85706547
68	BLK	0.84513706
69	BMPR2	0.84010948
70	TEC	0.83900127
71	TNK2	0.82451249
72	MAPK4	0.81690093
73	CAMK2G	0.80664264
74	TBK1	0.80544362
75	CSNK1G1	0.79200064
76	WEE1	0.75767080
77	TXK	0.74047339
78	PRKCG	0.72995374
79	GRK7	0.72801105
80	TNIK	0.71623624
81	TRIM28	0.70714839
82	PRKCQ	0.70491387
83	OBSCN	0.69441763
84	CAMKK2	0.68811640
85	SGK494	0.68417850
86	SGK223	0.68417850
87	EIF2AK2	0.67987119
88	ERBB2	0.66077394
89	TGFBR1	0.65796271
90	GRK5	0.64864505
91	CSNK1G3	0.64621829
92	IKBKB	0.63413337
93	CSK	0.61065313
94	EPHA3	0.60892753
95	TGFBR2	0.60197909
96	MAP3K3	0.59831295
97	BCR	0.59824904
98	MAP2K4	0.59077612
99	TRPM7	0.57018029
100	MAPK7	0.56747044
101	MAPK12	0.56542615
102	AKT3	0.54366713
103	CSNK1A1	0.53883663
104	LATS1	0.53807234
105	CAMK1	0.52885705
106	LIMK1	0.52616104
107	GSK3A	0.51677492
108	CAMK2D	0.50949534
109	NEK9	0.50773486
110	MAP2K1	0.50115635
111	PRKD2	0.47888998
112	PKN2	0.47525216
113	MAP2K2	0.47056553
114	PRKACG	0.46863466
115	MAP2K6	0.46379129
116	MKNK2	0.46080476
117	CSF1R	0.46069654
118	BMPR1B	0.45631764
119	LYN	0.45378389
120	PRKCE	0.44596799
121	NEK6	0.43215163
122	PRKACA	0.42624980
123	RPS6KA5	0.42605018
124	EPHB2	0.42507734
125	CAMK2B	0.42422846
126	FLT3	0.42299274
127	STK3	0.41468106
128	JAK1	0.40741378
129	CHUK	0.40041877
130	BTK	0.39154514
131	CAMK2A	0.39094980
132	PRKCZ	0.38298965
133	PRKCA	0.38218213
134	IGF1R	0.38215481
135	EPHA4	0.38119374
136	MAP3K4	0.37730167
137	MAP2K3	0.37610627
138	CAMK1D	0.36814960
139	GRK6	0.36487243
140	MAP4K1	0.36143023
141	CSNK1D	0.35882046
142	KIT	0.35636301
143	DYRK2	0.35591433
144	CSNK1A1L	0.34278697
145	JAK2	0.33921669
146	PRKAA1	0.33734097
147	CSNK1G2	0.31049490
148	PRKG1	0.30414281
149	STK11	0.28799293
150	SGK2	0.28439936
151	CAMKK1	0.27298733
152	ITK	0.25338999

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.81779022
2	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.91180046
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.90406982
4	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.71475636
5	Fatty acid degradation_Homo sapiens_hsa00071	2.56917274
6	Phototransduction_Homo sapiens_hsa04744	2.52124666
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.50264472
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.48012569
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.46948471
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.44585571
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.43866199
12	Fatty acid elongation_Homo sapiens_hsa00062	2.40220614
13	Butanoate metabolism_Homo sapiens_hsa00650	2.36934438
14	Propanoate metabolism_Homo sapiens_hsa00640	2.33841710
15	* Peroxisome_Homo sapiens_hsa04146	2.32676764
16	Arginine biosynthesis_Homo sapiens_hsa00220	2.23678002
17	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.23266121
18	Complement and coagulation cascades_Homo sapiens_hsa04610	2.20599956
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.19488817
20	Histidine metabolism_Homo sapiens_hsa00340	2.10479760
21	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.07881142
22	Fatty acid metabolism_Homo sapiens_hsa01212	2.07621900
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.02701088
24	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.91785313
25	Sulfur metabolism_Homo sapiens_hsa00920	1.90034768
26	PPAR signaling pathway_Homo sapiens_hsa03320	1.88657370
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.86772415
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.86125576
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.84339393
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.77156256
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.73480129
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.72951734
33	Retinol metabolism_Homo sapiens_hsa00830	1.72612913
34	Homologous recombination_Homo sapiens_hsa03440	1.66414512
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.65533070
36	Folate biosynthesis_Homo sapiens_hsa00790	1.55595401
37	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.53296884
38	RNA polymerase_Homo sapiens_hsa03020	1.52002489
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.51213049
40	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.50958027
41	Phenylalanine metabolism_Homo sapiens_hsa00360	1.50276731
42	Tyrosine metabolism_Homo sapiens_hsa00350	1.49638239
43	Caffeine metabolism_Homo sapiens_hsa00232	1.39101484
44	Taste transduction_Homo sapiens_hsa04742	1.38729867
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.37172748
46	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.27837339
47	Olfactory transduction_Homo sapiens_hsa04740	1.24728160
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.23136260
49	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.22739014
50	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.19979806
51	Sulfur relay system_Homo sapiens_hsa04122	1.18709582
52	ABC transporters_Homo sapiens_hsa02010	1.18411518
53	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.18107090
54	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17704155
55	Arginine and proline metabolism_Homo sapiens_hsa00330	1.14908592
56	Basal transcription factors_Homo sapiens_hsa03022	1.14579326
57	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.14435089
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.13300345
59	Nicotine addiction_Homo sapiens_hsa05033	1.13122186
60	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.12512464
61	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.10771948
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.10338730
63	Bile secretion_Homo sapiens_hsa04976	1.10288801
64	Selenocompound metabolism_Homo sapiens_hsa00450	1.09806996
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06681089
66	Fat digestion and absorption_Homo sapiens_hsa04975	1.04211091
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00220599
68	Carbon metabolism_Homo sapiens_hsa01200	0.97925000
69	Insulin secretion_Homo sapiens_hsa04911	0.97058060
70	Glutathione metabolism_Homo sapiens_hsa00480	0.96456583
71	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.94910703
72	Oxidative phosphorylation_Homo sapiens_hsa00190	0.88580621
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80750868
74	Salivary secretion_Homo sapiens_hsa04970	0.78871466
75	Morphine addiction_Homo sapiens_hsa05032	0.78025527
76	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77588377
77	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.75446198
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.74447359
79	Circadian entrainment_Homo sapiens_hsa04713	0.73019891
80	Metabolic pathways_Homo sapiens_hsa01100	0.72274683
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.71821636
82	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70158636
83	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.69319685
84	Serotonergic synapse_Homo sapiens_hsa04726	0.69261283
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.69182153
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.64936185
87	Linoleic acid metabolism_Homo sapiens_hsa00591	0.61777593
88	Parkinsons disease_Homo sapiens_hsa05012	0.60810602
89	Glutamatergic synapse_Homo sapiens_hsa04724	0.59533359
90	RNA degradation_Homo sapiens_hsa03018	0.58669306
91	Purine metabolism_Homo sapiens_hsa00230	0.57421665
92	Circadian rhythm_Homo sapiens_hsa04710	0.56402880
93	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.56008965
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.54531041
95	Lysine degradation_Homo sapiens_hsa00310	0.53692310
96	Protein export_Homo sapiens_hsa03060	0.53175451
97	Pentose phosphate pathway_Homo sapiens_hsa00030	0.51067682
98	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46613077
99	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.44394193
100	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.43773509
101	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.42628299
102	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.42424782
103	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.39434325
104	Ether lipid metabolism_Homo sapiens_hsa00565	0.37898576
105	Alzheimers disease_Homo sapiens_hsa05010	0.37707858
106	One carbon pool by folate_Homo sapiens_hsa00670	0.36800580
107	GABAergic synapse_Homo sapiens_hsa04727	0.36796019
108	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.36422506
109	Gastric acid secretion_Homo sapiens_hsa04971	0.32164822
110	Pancreatic secretion_Homo sapiens_hsa04972	0.29962731
111	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29501949
112	Long-term depression_Homo sapiens_hsa04730	0.29283710
113	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.25365883
114	Huntingtons disease_Homo sapiens_hsa05016	0.20692802
115	Galactose metabolism_Homo sapiens_hsa00052	0.18199487
116	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.13016714
117	Sphingolipid metabolism_Homo sapiens_hsa00600	0.12920469
118	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.11145409
119	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.09387702
120	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.08801573
121	Other glycan degradation_Homo sapiens_hsa00511	0.06217423
122	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.05321861
123	Prion diseases_Homo sapiens_hsa05020	0.03914922
124	Regulation of autophagy_Homo sapiens_hsa04140	0.03099302
125	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.01739065
126	Ribosome_Homo sapiens_hsa03010	0.00648092
127	AMPK signaling pathway_Homo sapiens_hsa04152	-0.1245656
128	Intestinal immune network for IgA production_Homo sapiens_hsa04672	-0.1137276
129	Lysosome_Homo sapiens_hsa04142	-0.1107036
130	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	-0.0903457
131	Insulin resistance_Homo sapiens_hsa04931	-0.0698127
132	Pyrimidine metabolism_Homo sapiens_hsa00240	-0.0652283
133	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.0330677
134	Mineral absorption_Homo sapiens_hsa04978	-0.0172147

PXMP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »