PXN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.34539647
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34539647
3antigen processing and presentation of endogenous antigen (GO:0019883)3.97972442
4positive regulation of Cdc42 GTPase activity (GO:0043089)3.52351137
5hypotonic response (GO:0006971)3.42119807
6detection of other organism (GO:0098543)3.40353770
7detection of bacterium (GO:0016045)3.28282009
8positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25185681
9positive regulation of histone deacetylation (GO:0031065)3.15447225
10apoptotic cell clearance (GO:0043277)3.14544681
11positive regulation by symbiont of host defense response (GO:0052509)3.13985540
12modulation by symbiont of host defense response (GO:0052031)3.13985540
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13985540
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13985540
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.13985540
16modulation by symbiont of host immune response (GO:0052553)3.13985540
17barbed-end actin filament capping (GO:0051016)3.11234787
18regulation of interleukin-12 biosynthetic process (GO:0045075)3.08398107
19positive regulation of gamma-delta T cell activation (GO:0046645)3.08283681
20cellular extravasation (GO:0045123)3.03082378
21response to laminar fluid shear stress (GO:0034616)2.98950416
22detection of external biotic stimulus (GO:0098581)2.94020822
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.92405318
24positive regulation of p38MAPK cascade (GO:1900745)2.91777023
25regulation of gamma-delta T cell differentiation (GO:0045586)2.91381381
26positive regulation of receptor recycling (GO:0001921)2.89766306
27response to muramyl dipeptide (GO:0032495)2.88501811
28regulation of necroptotic process (GO:0060544)2.87575623
29leukocyte aggregation (GO:0070486)2.87404403
30positive regulation of blood vessel endothelial cell migration (GO:0043536)2.85702038
31regulation of leukocyte degranulation (GO:0043300)2.84490516
32activation of Rac GTPase activity (GO:0032863)2.84288369
33detection of molecule of bacterial origin (GO:0032490)2.83936672
34cell adhesion mediated by integrin (GO:0033627)2.82782470
35Golgi transport vesicle coating (GO:0048200)2.81115517
36COPI coating of Golgi vesicle (GO:0048205)2.81115517
37regulation of interferon-beta biosynthetic process (GO:0045357)2.80765547
38negative regulation of granulocyte differentiation (GO:0030853)2.80676835
39low-density lipoprotein particle clearance (GO:0034383)2.79284630
40regulation of extracellular matrix disassembly (GO:0010715)2.78098867
41membrane raft organization (GO:0031579)2.74277563
42regulation of gamma-delta T cell activation (GO:0046643)2.73674947
43regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.71808739
44regulation of cholesterol storage (GO:0010885)2.70157543
45negative regulation of necroptotic process (GO:0060546)2.68742715
46morphogenesis of an endothelium (GO:0003159)2.67169891
47endothelial tube morphogenesis (GO:0061154)2.67169891
48hemidesmosome assembly (GO:0031581)2.65689032
49regulation of p38MAPK cascade (GO:1900744)2.63758796
50regulation of myeloid leukocyte mediated immunity (GO:0002886)2.62900792
51substrate-dependent cell migration (GO:0006929)2.59861840
52Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55505431
53detection of biotic stimulus (GO:0009595)2.54454705
54defense response to fungus (GO:0050832)2.54076455
55positive regulation of natural killer cell differentiation (GO:0032825)2.52484072
56regulation of T-helper 2 cell differentiation (GO:0045628)2.51068586
57positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.50838243
58negative regulation of lymphocyte mediated immunity (GO:0002707)2.50601226
59JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.50386152
60response to interleukin-15 (GO:0070672)2.50317831
61macrophage activation involved in immune response (GO:0002281)2.49923261
62negative regulation of erythrocyte differentiation (GO:0045647)2.49903568
63regulation of mast cell degranulation (GO:0043304)2.49880907
64response to fungus (GO:0009620)2.49572524
65protein localization to endosome (GO:0036010)2.49204070
66germ cell migration (GO:0008354)2.49138634
67NIK/NF-kappaB signaling (GO:0038061)2.47958998
68antigen processing and presentation via MHC class Ib (GO:0002475)2.47299597
69mannose metabolic process (GO:0006013)2.46705207
70regulation of defense response to virus by virus (GO:0050690)2.46587805
71neutrophil activation involved in immune response (GO:0002283)2.46350046
72endodermal cell differentiation (GO:0035987)2.45827003
73pinocytosis (GO:0006907)2.45590686
74negative regulation of leukocyte mediated immunity (GO:0002704)2.43637912
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42942120
76germinal center formation (GO:0002467)2.42878621
77positive regulation of lamellipodium assembly (GO:0010592)2.42218603
78regulation of T cell tolerance induction (GO:0002664)2.41550271
79response to peptidoglycan (GO:0032494)2.41090722
80desmosome organization (GO:0002934)2.40602693
81establishment of endothelial barrier (GO:0061028)2.40387314
82embryonic process involved in female pregnancy (GO:0060136)2.40312258
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.40271666
84leukocyte migration involved in inflammatory response (GO:0002523)2.40248053
85positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.39968745
86natural killer cell differentiation (GO:0001779)2.39343116
87negative regulation of phagocytosis (GO:0050765)2.38663582
88epithelial cell-cell adhesion (GO:0090136)2.38450011
89leukocyte cell-cell adhesion (GO:0007159)2.38435249
90regulation of early endosome to late endosome transport (GO:2000641)2.36854889
91negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.36083400
92negative regulation of glycoprotein biosynthetic process (GO:0010561)2.35600717
93hepatocyte apoptotic process (GO:0097284)2.35323873
94pentose-phosphate shunt (GO:0006098)2.35110080
95mesodermal cell differentiation (GO:0048333)2.34288436
96negative regulation of interleukin-12 production (GO:0032695)2.34204446
97* cell-substrate junction assembly (GO:0007044)2.33597179
98regulation of cholesterol homeostasis (GO:2000188)2.32317699
99positive regulation of lamellipodium organization (GO:1902745)2.31994057
100basement membrane organization (GO:0071711)2.31522252
101response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.31400388
102response to host (GO:0075136)2.31400388
103response to host defenses (GO:0052200)2.31400388
104regulation of necrotic cell death (GO:0010939)2.31207340
105response to fluid shear stress (GO:0034405)2.30854891
106* adherens junction assembly (GO:0034333)2.30395927
107negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.29842383
108positive regulation of protein deacetylation (GO:0090312)2.29329055
109regulation of regulated secretory pathway (GO:1903305)2.28554080
110cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.28454721
111positive thymic T cell selection (GO:0045059)2.28314311
112negative regulation of toll-like receptor signaling pathway (GO:0034122)2.28310406
113modulation by symbiont of host cellular process (GO:0044068)2.28280684
114* cell-substrate adherens junction assembly (GO:0007045)2.28075597
115* focal adhesion assembly (GO:0048041)2.28075597
116vascular endothelial growth factor signaling pathway (GO:0038084)2.28043317
117regulation of B cell receptor signaling pathway (GO:0050855)2.27051384
118epithelial cell differentiation involved in prostate gland development (GO:0060742)2.26511035
119negative regulation of cell size (GO:0045792)2.26406539
120regulation of type I interferon-mediated signaling pathway (GO:0060338)2.26153079
121negative regulation of viral release from host cell (GO:1902187)2.26059286
122regulation of tolerance induction (GO:0002643)2.25884673
123response to type I interferon (GO:0034340)2.25265451
124neutrophil activation (GO:0042119)2.24757154
125maternal placenta development (GO:0001893)2.24686374
126positive regulation of B cell differentiation (GO:0045579)2.24661432
127positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.24533036
128semaphorin-plexin signaling pathway (GO:0071526)2.24499030
1293-UTR-mediated mRNA stabilization (GO:0070935)2.24347973
130type I interferon signaling pathway (GO:0060337)2.24072310
131regulation of integrin activation (GO:0033623)2.23984744
132regulation of macrophage cytokine production (GO:0010935)2.22469638
133* integrin-mediated signaling pathway (GO:0007229)2.21057640
134immunoglobulin mediated immune response (GO:0016064)2.20941609
135positive regulation of interferon-alpha production (GO:0032727)2.19946349
136negative regulation of cell killing (GO:0031342)2.19754870
137negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.19754870
138positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.18594783
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.18022626
140response to host immune response (GO:0052572)2.18022626
141granulocyte activation (GO:0036230)2.17950945
142negative regulation of fatty acid transport (GO:2000192)2.17563724
143positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.17202511
144skin morphogenesis (GO:0043589)2.16637268
145cortical actin cytoskeleton organization (GO:0030866)2.16576395
146striated muscle atrophy (GO:0014891)2.16238608
147regulation of membrane protein ectodomain proteolysis (GO:0051043)2.14885530
148negative regulation of stress fiber assembly (GO:0051497)2.11351002
149apoptotic process involved in morphogenesis (GO:0060561)2.10782491
150stress fiber assembly (GO:0043149)2.10604777
151phospholipid homeostasis (GO:0055091)2.10505828
152regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.10158392
153regulation of interferon-alpha production (GO:0032647)2.08915383
154negative regulation of heart growth (GO:0061117)2.07534148
155negative regulation of cardiac muscle tissue growth (GO:0055022)2.07534148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.50874776
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.40406572
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.07860316
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.82834427
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.81786252
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51508384
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.46831845
8VDR_21846776_ChIP-Seq_THP-1_Human2.43704704
9MYC_22102868_ChIP-Seq_BL_Human2.39179702
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33987621
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.26020932
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24533301
13TCF7_22412390_ChIP-Seq_EML_Mouse2.24161190
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22781720
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.22752429
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16439199
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16404350
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16392611
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15072594
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.14977910
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.13907822
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06734844
23* IRF8_27001747_Chip-Seq_BMDM_Mouse2.06675650
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04191284
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03451610
26CLOCK_20551151_ChIP-Seq_293T_Human2.03036722
27MAF_26560356_Chip-Seq_TH1_Human1.96549796
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.92844210
29KDM2B_26808549_Chip-Seq_DND41_Human1.91930242
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91797622
31* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89891750
32VDR_24763502_ChIP-Seq_THP-1_Human1.85187338
33SCL_19346495_ChIP-Seq_HPC-7_Human1.84004908
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78976338
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.76833520
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75392733
37* LXR_22292898_ChIP-Seq_THP-1_Human1.69916773
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.69786691
39* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67941446
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67915373
41UTX_26944678_Chip-Seq_JUKART_Human1.67845070
42SPI1_23127762_ChIP-Seq_K562_Human1.61745862
43* LXR_22158963_ChIP-Seq_LIVER_Mouse1.61740902
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56758511
45* RACK7_27058665_Chip-Seq_MCF-7_Human1.56400556
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54439649
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53462353
48RUNX_20019798_ChIP-Seq_JUKART_Human1.52059713
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49529486
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.48970696
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48949430
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46598254
53MYB_26560356_Chip-Seq_TH2_Human1.45509288
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42951725
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.42346204
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41897751
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.41043838
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40250306
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.40194795
60MYB_26560356_Chip-Seq_TH1_Human1.37280724
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33608171
62* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33605246
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.31199845
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30728875
65NCOR1_26117541_ChIP-Seq_K562_Human1.28688964
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.27635171
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24182181
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23971407
69* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22482041
70* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22406344
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.22224538
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.22041152
73ATF3_27146783_Chip-Seq_COLON_Human1.21978508
74GATA1_19941826_ChIP-Seq_K562_Human1.21645738
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20700823
76* KDM2B_26808549_Chip-Seq_JURKAT_Human1.20512132
77HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20301259
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19921321
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18997890
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.18955292
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18783786
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18622724
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18597311
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.18565118
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.18565118
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18326860
87ZNF263_19887448_ChIP-Seq_K562_Human1.16709399
88* SPI1_23547873_ChIP-Seq_NB4_Human1.16258058
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16123937
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15773597
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14641524
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14466699
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14423163
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13967314
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13358257
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13309720
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13164698
98* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13051226
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12821705
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11982804
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.11174159
102IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11154025
103MAF_26560356_Chip-Seq_TH2_Human1.10333338
104SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10145691
105UBF1/2_26484160_Chip-Seq_HMECs_Human1.09823011
106TP53_22127205_ChIP-Seq_IMR90_Human1.09605638
107* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09455015
108KDM2B_26808549_Chip-Seq_K562_Human1.07122868
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06453900
110* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06171140
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05848615
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05743571
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05346735
114* GATA2_19941826_ChIP-Seq_K562_Human1.04580617
115* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04513374
116* P68_20966046_ChIP-Seq_HELA_Human1.04310087
117GATA6_25053715_ChIP-Seq_YYC3_Human1.04231150
118SMC4_20622854_ChIP-Seq_HELA_Human1.03251064
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02942819
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02184650
121PU_27001747_Chip-Seq_BMDM_Mouse1.02180987
122RUNX1_27514584_Chip-Seq_MCF-7_Human1.02001644
123NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01154978
124VDR_24787735_ChIP-Seq_THP-1_Human0.98166870
125* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97535627
126* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97535627
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96741458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.16133027
2MP0003300_gastrointestinal_ulcer2.91447444
3MP0003303_peritoneal_inflammation2.81659790
4MP0009278_abnormal_bone_marrow2.67873362
5MP0003436_decreased_susceptibility_to2.41942557
6MP0005451_abnormal_body_composition2.41890652
7MP0008260_abnormal_autophagy2.40135514
8MP0003566_abnormal_cell_adhesion2.16272182
9MP0003191_abnormal_cellular_cholesterol2.07779527
10MP0000685_abnormal_immune_system1.93003827
11MP0005076_abnormal_cell_differentiation1.89173369
12MP0010352_gastrointestinal_tract_polyps1.89083348
13MP0004858_abnormal_nervous_system1.86816598
14MP0001835_abnormal_antigen_presentation1.83583553
15MP0004510_myositis1.82836191
16MP0009840_abnormal_foam_cell1.80607257
17MP0005360_urolithiasis1.64802335
18MP0005058_abnormal_lysosome_morphology1.63550842
19MP0002419_abnormal_innate_immunity1.62385512
20MP0009785_altered_susceptibility_to1.58247408
21MP0004947_skin_inflammation1.58223601
22MP0002138_abnormal_hepatobiliary_system1.56244113
23MP0005023_abnormal_wound_healing1.55090719
24MP0005464_abnormal_platelet_physiology1.54914083
25MP0008438_abnormal_cutaneous_collagen1.54492390
26MP0001545_abnormal_hematopoietic_system1.53360869
27MP0005397_hematopoietic_system_phenotyp1.53360869
28MP0003279_aneurysm1.52828856
29MP0001958_emphysema1.52717514
30MP0005387_immune_system_phenotype1.51845720
31MP0001790_abnormal_immune_system1.51845720
32MP0001533_abnormal_skeleton_physiology1.49464387
33MP0000343_altered_response_to1.49460267
34MP0002166_altered_tumor_susceptibility1.49305479
35MP0005025_abnormal_response_to1.47540551
36MP0003045_fibrosis1.46393754
37MP0002796_impaired_skin_barrier1.45383403
38MP0005409_darkened_coat_color1.44675370
39MP0010155_abnormal_intestine_physiology1.44282304
40MP0010368_abnormal_lymphatic_system1.44119175
41MP0002060_abnormal_skin_morphology1.43670256
42MP0000733_abnormal_muscle_development1.42510829
43MP0003724_increased_susceptibility_to1.42116196
44MP0004808_abnormal_hematopoietic_stem1.42048809
45MP0003828_pulmonary_edema1.37494443
46MP0002405_respiratory_system_inflammati1.36323769
47MP0005167_abnormal_blood-brain_barrier1.36237646
48MP0002452_abnormal_antigen_presenting1.35440426
49MP0005164_abnormal_response_to1.35086912
50MP0001800_abnormal_humoral_immune1.34223247
51MP0001853_heart_inflammation1.33625146
52MP0001873_stomach_inflammation1.33151828
53MP0000751_myopathy1.32805465
54MP0004272_abnormal_basement_membrane1.32694163
55MP0005000_abnormal_immune_tolerance1.32579148
56MP0003448_altered_tumor_morphology1.24894733
57MP0006054_spinal_hemorrhage1.23562789
58MP0003091_abnormal_cell_migration1.23528576
59MP0010234_abnormal_vibrissa_follicle1.23293812
60MP0004381_abnormal_hair_follicle1.22746070
61MP0002396_abnormal_hematopoietic_system1.22350298
62MP0001819_abnormal_immune_cell1.19574172
63MP0004233_abnormal_muscle_weight1.18998410
64MP0002420_abnormal_adaptive_immunity1.18843846
65MP0002723_abnormal_immune_serum1.18339921
66MP0010307_abnormal_tumor_latency1.17586015
67MP0004883_abnormal_blood_vessel1.16820880
68MP0001845_abnormal_inflammatory_respons1.16425452
69MP0003453_abnormal_keratinocyte_physiol1.16213114
70MP0006082_CNS_inflammation1.16178000
71MP0000858_altered_metastatic_potential1.14165809
72MP0000678_abnormal_parathyroid_gland1.13395685
73MP0000465_gastrointestinal_hemorrhage1.10942605
74MP0000767_abnormal_smooth_muscle1.10181087
75MP0002132_abnormal_respiratory_system1.10146070
76MP0005390_skeleton_phenotype1.08760148
77MP0004264_abnormal_extraembryonic_tissu1.07985450
78MP0002148_abnormal_hypersensitivity_rea1.07484905
79MP0001348_abnormal_lacrimal_gland1.07263419
80MP0003075_altered_response_to1.03498995
81MP0001879_abnormal_lymphatic_vessel1.01608462
82MP0010630_abnormal_cardiac_muscle1.01409868
83MP0005671_abnormal_response_to1.01199884
84MP0002933_joint_inflammation1.00899628
85MP0001851_eye_inflammation1.00783449
86MP0002006_tumorigenesis0.99990766
87MP0002877_abnormal_melanocyte_morpholog0.99733675
88MP0002398_abnormal_bone_marrow0.99641438
89MP0008961_abnormal_basal_metabolism0.99619158
90MP0003252_abnormal_bile_duct0.99176868
91MP0005501_abnormal_skin_physiology0.98790961
92MP0001849_ear_inflammation0.98731768
93MP0001216_abnormal_epidermal_layer0.98014466
94MP0004084_abnormal_cardiac_muscle0.97228525
95MP0000750_abnormal_muscle_regeneration0.97161209
96MP0000716_abnormal_immune_system0.97064509
97MP0003172_abnormal_lysosome_physiology0.96239349
98MP0004087_abnormal_muscle_fiber0.95114085
99MP0008469_abnormal_protein_level0.94819040
100MP0000609_abnormal_liver_physiology0.91817759
101MP0005623_abnormal_meninges_morphology0.90345083
102MP0009764_decreased_sensitivity_to0.90283909
103MP0000689_abnormal_spleen_morphology0.88966747
104MP0000249_abnormal_blood_vessel0.88291318
105MP0002722_abnormal_immune_system0.87127837
106MP0001542_abnormal_bone_strength0.87096840
107MP0009333_abnormal_splenocyte_physiolog0.86795775
108MP0005257_abnormal_intraocular_pressure0.86729740
109MP0003866_abnormal_defecation0.86383820
110MP0002429_abnormal_blood_cell0.85763189
111MP0002998_abnormal_bone_remodeling0.85740611
112MP0005375_adipose_tissue_phenotype0.85444033
113MP0003950_abnormal_plasma_membrane0.85058128
114MP0001915_intracranial_hemorrhage0.85012725
115MP0000490_abnormal_crypts_of0.84792780
116MP0005666_abnormal_adipose_tissue0.84370902
117MP0005275_abnormal_skin_tensile0.83406425
118MP0004185_abnormal_adipocyte_glucose0.83094537
119MP0005621_abnormal_cell_physiology0.83039247
120MP0005166_decreased_susceptibility_to0.83025398
121MP0005083_abnormal_biliary_tract0.82282028
122MP0009053_abnormal_anal_canal0.81722935
123MP0000467_abnormal_esophagus_morphology0.81278454
124MP0003795_abnormal_bone_structure0.81259894
125MP0000749_muscle_degeneration0.80513664
126MP0002136_abnormal_kidney_physiology0.80155102
127MP0000703_abnormal_thymus_morphology0.80009365
128MP0002139_abnormal_hepatobiliary_system0.79340623
129MP0003763_abnormal_thymus_physiology0.77358082
130MP0004130_abnormal_muscle_cell0.76844905
131MP0009643_abnormal_urine_homeostasis0.75946372
132MP0002254_reproductive_system_inflammat0.74671163

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.85193259
2Cerebral aneurysm (HP:0004944)3.49369807
3Recurrent abscess formation (HP:0002722)3.14530081
4Distal lower limb muscle weakness (HP:0009053)3.07572013
5Interstitial pulmonary disease (HP:0006530)2.99009261
6Recurrent bacterial skin infections (HP:0005406)2.90270181
7Distal lower limb amyotrophy (HP:0008944)2.90029538
8Hematochezia (HP:0002573)2.88648712
9Broad face (HP:0000283)2.86528984
10Spontaneous hematomas (HP:0007420)2.76423411
11Recurrent gram-negative bacterial infections (HP:0005420)2.73612378
12Arterial tortuosity (HP:0005116)2.72944141
13Fragile skin (HP:0001030)2.70360735
14Abnormality of the nasal mucosa (HP:0000433)2.69368769
15Systemic lupus erythematosus (HP:0002725)2.61836538
16Vascular tortuosity (HP:0004948)2.61422214
17Increased connective tissue (HP:0009025)2.60866546
18Vertebral compression fractures (HP:0002953)2.56225652
19Increased variability in muscle fiber diameter (HP:0003557)2.50821877
20Aortic aneurysm (HP:0004942)2.49532727
21Abnormality of skeletal muscle fiber size (HP:0012084)2.46532170
22Protrusio acetabuli (HP:0003179)2.46186226
23Myositis (HP:0100614)2.45908911
24Obstructive sleep apnea (HP:0002870)2.42748900
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.41022058
26Osteolytic defects of the hand bones (HP:0009699)2.41022058
27Autoimmune thrombocytopenia (HP:0001973)2.40462683
28Ulnar deviation of the wrist (HP:0003049)2.37591587
29Polycythemia (HP:0001901)2.31793434
30Myocardial infarction (HP:0001658)2.31772749
31Pustule (HP:0200039)2.30695321
32Spinal rigidity (HP:0003306)2.28947820
33Esophageal varix (HP:0002040)2.28613219
34Nasal polyposis (HP:0100582)2.27457573
35Abnormality of macrophages (HP:0004311)2.27435000
36Increased density of long bones (HP:0006392)2.27153591
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.27000894
38Recurrent fungal infections (HP:0002841)2.25489517
39Peritonitis (HP:0002586)2.24142415
40Cellulitis (HP:0100658)2.23996328
41Lymphangioma (HP:0100764)2.23693025
42Upper limb amyotrophy (HP:0009129)2.22216982
43Distal upper limb amyotrophy (HP:0007149)2.22216982
44Increased cerebral lipofuscin (HP:0011813)2.20452209
45Shallow orbits (HP:0000586)2.16212167
46Colitis (HP:0002583)2.15895761
47Aneurysm (HP:0002617)2.15555032
48Gingivitis (HP:0000230)2.15117629
49Type 1 muscle fiber predominance (HP:0003803)2.14846164
50Hand muscle atrophy (HP:0009130)2.14828758
51Mitral valve prolapse (HP:0001634)2.14763861
52Short nail (HP:0001799)2.14057981
53Abnormality of the distal phalanges of the toes (HP:0010182)2.13731281
54Asymmetric septal hypertrophy (HP:0001670)2.13470715
55Broad metatarsal (HP:0001783)2.12964320
56Amyloidosis (HP:0011034)2.11245340
57Arterial thrombosis (HP:0004420)2.10845150
58Periodontitis (HP:0000704)2.10584345
59Right ventricular cardiomyopathy (HP:0011663)2.09879902
60Thin bony cortex (HP:0002753)2.09077134
61Deep venous thrombosis (HP:0002625)2.08509617
62Aortic dissection (HP:0002647)2.07556363
63Elevated erythrocyte sedimentation rate (HP:0003565)2.06647252
64Impaired platelet aggregation (HP:0003540)2.06409609
65Abnormal platelet function (HP:0011869)2.06409609
66Cervical subluxation (HP:0003308)2.05682291
67Gastrointestinal inflammation (HP:0004386)2.02945467
68Inflammation of the large intestine (HP:0002037)2.02662223
69Orchitis (HP:0100796)2.02417573
70Easy fatigability (HP:0003388)2.01803893
71Mildly elevated creatine phosphokinase (HP:0008180)2.01387743
72Nephritis (HP:0000123)1.99824693
73Atrophic scars (HP:0001075)1.99758851
74Ulnar bowing (HP:0003031)1.99566030
75Ankle contracture (HP:0006466)1.97867521
76Thick nail (HP:0001805)1.96608651
77Gastrointestinal infarctions (HP:0005244)1.96191791
78Hyperacusis (HP:0010780)1.96048995
79Spondylolisthesis (HP:0003302)1.96040570
80Frequent falls (HP:0002359)1.95506533
81Blue sclerae (HP:0000592)1.95155252
82Subacute progressive viral hepatitis (HP:0006572)1.94152662
83Achilles tendon contracture (HP:0001771)1.93827807
84Mediastinal lymphadenopathy (HP:0100721)1.93269898
85Milia (HP:0001056)1.89734463
86Chest pain (HP:0100749)1.89403518
87Disproportionate tall stature (HP:0001519)1.89187264
88Segmental peripheral demyelination/remyelination (HP:0003481)1.88383832
89Spinal cord lesions (HP:0100561)1.88309171
90Syringomyelia (HP:0003396)1.88309171
91Nail dystrophy (HP:0008404)1.87351859
92Abnormality of oral frenula (HP:0000190)1.87163942
93Chronic otitis media (HP:0000389)1.86367054
94Abnormal vertebral ossification (HP:0100569)1.85760629
95Hyporeflexia of lower limbs (HP:0002600)1.85513626
96Muscle fiber splitting (HP:0003555)1.84769839
97Abnormal platelet volume (HP:0011876)1.83878768
98Recurrent viral infections (HP:0004429)1.83799775
99Vacuolated lymphocytes (HP:0001922)1.83639791
100Lower limb amyotrophy (HP:0007210)1.82685350
101Difficulty running (HP:0009046)1.81718819
102Urinary glycosaminoglycan excretion (HP:0003541)1.81340835
103Mucopolysacchariduria (HP:0008155)1.81340835
104Obstructive lung disease (HP:0006536)1.80879425
105Chronic obstructive pulmonary disease (HP:0006510)1.80879425
106Exercise-induced muscle cramps (HP:0003710)1.80763673
107Difficulty climbing stairs (HP:0003551)1.80380224
108Mitral regurgitation (HP:0001653)1.79679124
109Dilatation of the ascending aorta (HP:0005111)1.78762918
110Rectal prolapse (HP:0002035)1.78161319
111Slender build (HP:0001533)1.77717437
112Generalized amyotrophy (HP:0003700)1.77270607
113Dysostosis multiplex (HP:0000943)1.76154696
114Ankyloglossia (HP:0010296)1.75597104
115Trismus (HP:0000211)1.75244854
116Abnormality of the fingertips (HP:0001211)1.74728614
117Recurrent skin infections (HP:0001581)1.74691004
118Reduced subcutaneous adipose tissue (HP:0003758)1.74263546
119Retrobulbar optic neuritis (HP:0100654)1.73166371
120Optic neuritis (HP:0100653)1.73166371
121Increased mean platelet volume (HP:0011877)1.72427894
122Prolonged bleeding time (HP:0003010)1.71744851
123Flat acetabular roof (HP:0003180)1.71582079
124Genu recurvatum (HP:0002816)1.71509886
125Wormian bones (HP:0002645)1.69807164
126Hypertriglyceridemia (HP:0002155)1.69747314
127Long palpebral fissure (HP:0000637)1.69663560
128Complement deficiency (HP:0004431)1.69634826
129Bicuspid aortic valve (HP:0001647)1.69575037
130Abnormality of complement system (HP:0005339)1.69112421
131Urticaria (HP:0001025)1.67828955
132Metaphyseal cupping (HP:0003021)1.67679286
133Fatigue (HP:0012378)1.67045288
134Gingival bleeding (HP:0000225)1.66278103
135Premature rupture of membranes (HP:0001788)1.66033068
136Axonal loss (HP:0003447)1.65820483
137Increased neuronal autofluorescent lipopigment (HP:0002074)1.65539016
138Abnormality of the Achilles tendon (HP:0005109)1.65165710
139Persistence of primary teeth (HP:0006335)1.64559234
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.64043762
141Abnormality of polysaccharide metabolism (HP:0011012)1.64043762
142Abnormality of glycosaminoglycan metabolism (HP:0004371)1.64043762
143Glomerulonephritis (HP:0000099)1.63649393
144Ventricular tachycardia (HP:0004756)1.62983421
145Hemorrhage of the eye (HP:0011885)1.62982778
146Increased IgE level (HP:0003212)1.62953396
147Fragile nails (HP:0001808)1.62785853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.31890111
2ERN13.53010693
3PKN23.20426626
4EEF2K2.73944330
5TTN2.73593319
6RIPK12.62012431
7PRPF4B2.50213619
8MST1R2.48175572
9MAP4K12.44226143
10MAP3K102.30118466
11TGFBR22.27459632
12SMG12.23981377
13STK102.02348779
14MAP2K31.89333326
15TYK21.85919110
16LRRK21.83550089
17TBK11.69457061
18SIK11.69183129
19* PTK61.68075999
20CDK121.65433223
21FGFR41.64558140
22SIK31.59952160
23PRKD21.56745348
24LMTK21.50326708
25KDR1.47584404
26MET1.38548817
27JAK31.37444380
28BMX1.34809645
29MAP3K131.33695212
30ZAP701.33575533
31KSR21.32407769
32TESK21.30173674
33MAP3K141.28765131
34DMPK1.27554065
35JAK11.27451956
36STK381.25111689
37TIE11.24047300
38GRK61.21271140
39MAP3K11.19850108
40TAOK21.19321074
41TRPM71.18229446
42MAP3K31.17381508
43CAMK1D1.15488390
44CDC42BPA1.09358133
45KIT1.09348060
46PDGFRA1.06881001
47RPS6KA41.06094405
48CSF1R1.04684008
49CDK61.04404288
50MARK21.04142834
51FGFR31.04080875
52MOS1.02778603
53MAP3K61.02776594
54BLK1.01348076
55ICK1.00162637
56HCK0.99409844
57IKBKE0.98777045
58CHUK0.97610556
59NME20.94535529
60TNK20.94031710
61MAP3K110.93163966
62IRAK40.92548364
63PDPK10.91151848
64CAMK1G0.89772136
65* CSK0.88116990
66FES0.87923139
67MAP3K70.87101268
68ITK0.84748884
69JAK20.83852170
70FLT30.83840202
71TGFBR10.83418292
72MTOR0.81753491
73NEK90.80051101
74STK30.79768395
75TAOK30.79260454
76FGR0.77793358
77IKBKB0.77033376
78* BTK0.76870904
79PRKG20.75953675
80NTRK10.75922821
81EPHA30.75701787
82PIM10.75490596
83ARAF0.74570951
84MAP3K20.73354047
85MAP3K80.73173730
86LATS10.72046965
87SCYL20.71735525
88EPHA20.71516234
89SIK20.70052752
90ALK0.68977387
91ERBB40.68664213
92TAOK10.68377110
93PAK20.68276997
94PDGFRB0.68065035
95IRAK20.65505197
96HIPK20.65150032
97CDK40.64417280
98TESK10.63204242
99* PAK40.63018220
100NEK20.62058568
101MATK0.61628171
102MAPKAPK30.60404964
103* PTK20.60335421
104RPS6KB20.58279724
105DDR20.57662490
106MAP2K20.56969383
107LIMK10.56908286
108RPS6KA60.56517008
109PDK10.56294188
110MARK30.56239650
111ILK0.55401408
112YES10.54524499
113MYLK0.54404581
114IRAK30.54391797
115LCK0.53928511
116MAPKAPK20.53557873
117PIK3CG0.52437847
118RPS6KL10.52165442
119RPS6KC10.52165442
120RET0.51180737
121CLK10.50707834
122MAPK110.50156990
123KSR10.49118602
124DYRK1B0.48844243
125EGFR0.48755636
126ROCK20.48568325
127RPS6KA20.47083819
128PRKAA20.46656595
129MELK0.46639680
130CDK90.45710109
131MAPK70.45444291
132RPS6KA10.44414110
133PRKD10.42846801
134SGK30.42359500
135EPHB20.41686751
136TEC0.41080602
137RIPK40.40371488
138LATS20.40158811
139MAPK120.39246407
140IRAK10.37119144

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.40908099
2Staphylococcus aureus infection_Homo sapiens_hsa051502.19196346
3Osteoclast differentiation_Homo sapiens_hsa043802.00938045
4Toxoplasmosis_Homo sapiens_hsa051451.83404393
5* Leukocyte transendothelial migration_Homo sapiens_hsa046701.74037351
6Viral myocarditis_Homo sapiens_hsa054161.64464671
7B cell receptor signaling pathway_Homo sapiens_hsa046621.58829403
8Small cell lung cancer_Homo sapiens_hsa052221.57798743
9Chronic myeloid leukemia_Homo sapiens_hsa052201.56847013
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44793222
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43720266
12* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42994967
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42885954
14Amoebiasis_Homo sapiens_hsa051461.42191856
15Caffeine metabolism_Homo sapiens_hsa002321.39950010
16Acute myeloid leukemia_Homo sapiens_hsa052211.37833517
17* Focal adhesion_Homo sapiens_hsa045101.36675430
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.35959270
19Thyroid cancer_Homo sapiens_hsa052161.35586607
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.32487845
21Pertussis_Homo sapiens_hsa051331.30500462
22Legionellosis_Homo sapiens_hsa051341.29706226
23Shigellosis_Homo sapiens_hsa051311.29364689
24TNF signaling pathway_Homo sapiens_hsa046681.28800969
25Insulin resistance_Homo sapiens_hsa049311.28074369
26Malaria_Homo sapiens_hsa051441.26536568
27ECM-receptor interaction_Homo sapiens_hsa045121.23539067
28Measles_Homo sapiens_hsa051621.23414068
29Antigen processing and presentation_Homo sapiens_hsa046121.22585940
30* Proteoglycans in cancer_Homo sapiens_hsa052051.20172455
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18948356
32Lysine degradation_Homo sapiens_hsa003101.17858833
33Apoptosis_Homo sapiens_hsa042101.17315731
34Adherens junction_Homo sapiens_hsa045201.17160307
35Pancreatic cancer_Homo sapiens_hsa052121.17109869
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17013150
37Complement and coagulation cascades_Homo sapiens_hsa046101.15675448
38Tuberculosis_Homo sapiens_hsa051521.15601467
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15267996
40Platelet activation_Homo sapiens_hsa046111.12776452
41Influenza A_Homo sapiens_hsa051641.06948583
42Notch signaling pathway_Homo sapiens_hsa043301.06922825
43Other glycan degradation_Homo sapiens_hsa005111.05781212
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05597190
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05314099
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.05244131
47Nitrogen metabolism_Homo sapiens_hsa009101.04887272
48Salmonella infection_Homo sapiens_hsa051321.04555675
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.03573374
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02252277
51Lysosome_Homo sapiens_hsa041421.00432144
52ErbB signaling pathway_Homo sapiens_hsa040120.99166407
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.97553224
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96722854
55Hepatitis B_Homo sapiens_hsa051610.94844704
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92040043
57GnRH signaling pathway_Homo sapiens_hsa049120.91375091
58Colorectal cancer_Homo sapiens_hsa052100.90963850
59Fatty acid degradation_Homo sapiens_hsa000710.89992346
60Hematopoietic cell lineage_Homo sapiens_hsa046400.89678019
61PPAR signaling pathway_Homo sapiens_hsa033200.89487460
62Glioma_Homo sapiens_hsa052140.89077894
63Phagosome_Homo sapiens_hsa041450.86165757
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85675593
65Prostate cancer_Homo sapiens_hsa052150.85428452
66Arginine biosynthesis_Homo sapiens_hsa002200.85222158
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.84733379
68Herpes simplex infection_Homo sapiens_hsa051680.83770400
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.83762824
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83167462
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82475317
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.82418825
73Choline metabolism in cancer_Homo sapiens_hsa052310.80628842
74* VEGF signaling pathway_Homo sapiens_hsa043700.80372352
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80263336
76* Chemokine signaling pathway_Homo sapiens_hsa040620.80042177
77Galactose metabolism_Homo sapiens_hsa000520.79373132
78Rap1 signaling pathway_Homo sapiens_hsa040150.79151480
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77980149
80Non-small cell lung cancer_Homo sapiens_hsa052230.77839774
81Inositol phosphate metabolism_Homo sapiens_hsa005620.77737866
82Bladder cancer_Homo sapiens_hsa052190.77707386
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77335335
84Hepatitis C_Homo sapiens_hsa051600.77147652
85mTOR signaling pathway_Homo sapiens_hsa041500.76759934
86HIF-1 signaling pathway_Homo sapiens_hsa040660.75648272
87MicroRNAs in cancer_Homo sapiens_hsa052060.75072127
88T cell receptor signaling pathway_Homo sapiens_hsa046600.74545041
89Estrogen signaling pathway_Homo sapiens_hsa049150.73969917
90* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73897319
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73889922
92Starch and sucrose metabolism_Homo sapiens_hsa005000.73601134
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73508115
94Pathways in cancer_Homo sapiens_hsa052000.72677959
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71194421
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70766568
97African trypanosomiasis_Homo sapiens_hsa051430.70739590
98Fructose and mannose metabolism_Homo sapiens_hsa000510.69689001
99Dilated cardiomyopathy_Homo sapiens_hsa054140.69650739
100Prolactin signaling pathway_Homo sapiens_hsa049170.69562742
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69535572
102Prion diseases_Homo sapiens_hsa050200.69333539
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68808788
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67237254
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.66033003
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65980502
107HTLV-I infection_Homo sapiens_hsa051660.64785672
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64742301
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62205006
110Bile secretion_Homo sapiens_hsa049760.61700856
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59253111
112ABC transporters_Homo sapiens_hsa020100.58815630
113Pentose phosphate pathway_Homo sapiens_hsa000300.58402098
114Primary immunodeficiency_Homo sapiens_hsa053400.58041628
115Dorso-ventral axis formation_Homo sapiens_hsa043200.58024761
116Endometrial cancer_Homo sapiens_hsa052130.58017765
117* Viral carcinogenesis_Homo sapiens_hsa052030.57675876
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57651814
119Endocytosis_Homo sapiens_hsa041440.55705233
120Protein digestion and absorption_Homo sapiens_hsa049740.55567955
121Renal cell carcinoma_Homo sapiens_hsa052110.55544277
122FoxO signaling pathway_Homo sapiens_hsa040680.52855321
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52389709
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50735877
125Insulin signaling pathway_Homo sapiens_hsa049100.49501250
126AMPK signaling pathway_Homo sapiens_hsa041520.47985828

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