PYCARD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.31170662
2viral transcription (GO:0019083)5.38607022
3translational termination (GO:0006415)5.14764085
4ribosomal small subunit biogenesis (GO:0042274)4.69414508
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51386930
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.50271530
7maturation of SSU-rRNA (GO:0030490)4.37320852
8protein targeting to ER (GO:0045047)4.37296829
9cotranslational protein targeting to membrane (GO:0006613)4.37091727
10negative regulation of cell killing (GO:0031342)4.34983919
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.34983919
12translational elongation (GO:0006414)4.30144406
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.14879768
14protein localization to endoplasmic reticulum (GO:0070972)4.12247137
15neutrophil activation involved in immune response (GO:0002283)4.02361551
16viral life cycle (GO:0019058)4.00213337
17ribosomal large subunit biogenesis (GO:0042273)4.00028010
18positive thymic T cell selection (GO:0045059)3.95546073
19cellular protein complex disassembly (GO:0043624)3.87654474
20DNA deamination (GO:0045006)3.83630786
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.81290371
22regulation of mast cell degranulation (GO:0043304)3.75201984
23macrophage activation involved in immune response (GO:0002281)3.69577054
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66321879
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66321879
26detection of external biotic stimulus (GO:0098581)3.63500781
27negative regulation of interleukin-12 production (GO:0032695)3.61921832
28regulation of gamma-delta T cell activation (GO:0046643)3.58153977
29positive regulation of mast cell activation (GO:0033005)3.57291254
30translational initiation (GO:0006413)3.53861826
31positive regulation of mast cell activation involved in immune response (GO:0033008)3.52436284
32positive regulation of mast cell degranulation (GO:0043306)3.52436284
33antigen processing and presentation of endogenous antigen (GO:0019883)3.46378009
34regulation of myeloid leukocyte mediated immunity (GO:0002886)3.43695212
35regulation of mast cell activation involved in immune response (GO:0033006)3.42103526
36immunoglobulin mediated immune response (GO:0016064)3.40346510
37B cell receptor signaling pathway (GO:0050853)3.37969378
38* regulation of antigen processing and presentation (GO:0002577)3.37631739
39regulation of dendritic cell antigen processing and presentation (GO:0002604)3.34512843
40regulation of mast cell activation (GO:0033003)3.34122347
41regulation of gamma-delta T cell differentiation (GO:0045586)3.31650430
42microglial cell activation (GO:0001774)3.30151908
43* myeloid cell activation involved in immune response (GO:0002275)3.29632636
44Arp2/3 complex-mediated actin nucleation (GO:0034314)3.28907613
45protein complex disassembly (GO:0043241)3.27941311
46cytidine deamination (GO:0009972)3.25053623
47cytidine metabolic process (GO:0046087)3.25053623
48cytidine catabolic process (GO:0006216)3.25053623
49respiratory burst (GO:0045730)3.21702540
50positive regulation of gamma-delta T cell activation (GO:0046645)3.21465311
51detection of biotic stimulus (GO:0009595)3.19723629
52regulation of leukocyte degranulation (GO:0043300)3.19469816
53cellular extravasation (GO:0045123)3.19317747
54mature B cell differentiation involved in immune response (GO:0002313)3.18270967
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16812009
56neutrophil activation (GO:0042119)3.11613801
57macromolecular complex disassembly (GO:0032984)3.08306115
58regulation of T cell tolerance induction (GO:0002664)3.08273579
59telomere maintenance via semi-conservative replication (GO:0032201)3.06383008
60* positive regulation of antigen processing and presentation (GO:0002579)3.06067871
61response to host immune response (GO:0052572)3.05825852
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05825852
63regulation of tolerance induction (GO:0002643)3.03627049
64negative regulation of phagocytosis (GO:0050765)3.03315995
65leukocyte degranulation (GO:0043299)3.01872872
66response to interferon-beta (GO:0035456)3.01651155
67superoxide anion generation (GO:0042554)3.00772205
68negative regulation of leukocyte mediated immunity (GO:0002704)3.00394843
69production of molecular mediator involved in inflammatory response (GO:0002532)3.00086074
70positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.99492236
71positive T cell selection (GO:0043368)2.97788863
72antigen processing and presentation via MHC class Ib (GO:0002475)2.97254899
73granulocyte activation (GO:0036230)2.95844211
74purine deoxyribonucleotide catabolic process (GO:0009155)2.95187662
75negative regulation of lymphocyte mediated immunity (GO:0002707)2.93606495
76cellular response to interferon-beta (GO:0035458)2.92751891
77B cell mediated immunity (GO:0019724)2.91347893
78cellular response to zinc ion (GO:0071294)2.91068093
79negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.90981856
80telomere maintenance via recombination (GO:0000722)2.89312510
81regulation of regulatory T cell differentiation (GO:0045589)2.88485572
82regulation of hypersensitivity (GO:0002883)2.88428520
83response to peptidoglycan (GO:0032494)2.88084038
84regulation of B cell receptor signaling pathway (GO:0050855)2.86599053
85macrophage activation (GO:0042116)2.85987931
86positive regulation of T cell mediated cytotoxicity (GO:0001916)2.85496511
87regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85180537
88regulation of alpha-beta T cell proliferation (GO:0046640)2.83954099
89pyrimidine ribonucleoside catabolic process (GO:0046133)2.82956591
90protein targeting to membrane (GO:0006612)2.81662408
91cellular response to interferon-gamma (GO:0071346)2.81204266
92nuclear-transcribed mRNA catabolic process (GO:0000956)2.80517001
93negative thymic T cell selection (GO:0045060)2.79793181
94response to type I interferon (GO:0034340)2.79009035
95type I interferon signaling pathway (GO:0060337)2.78596994
96cellular response to type I interferon (GO:0071357)2.78596994
97lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78591021
98detection of molecule of bacterial origin (GO:0032490)2.78537226
99detection of other organism (GO:0098543)2.77199577
100leukocyte aggregation (GO:0070486)2.77145456
101regulation of T cell mediated cytotoxicity (GO:0001914)2.76777715
102positive regulation of monocyte chemotaxis (GO:0090026)2.76468718
103regulation of respiratory burst (GO:0060263)2.75928017
104neutrophil mediated immunity (GO:0002446)2.75356972
105negative regulation of innate immune response (GO:0045824)2.74982866
106interferon-gamma production (GO:0032609)2.74511057
107negative T cell selection (GO:0043383)2.73935747
108* regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73754940
109T cell selection (GO:0045058)2.72443214
110mast cell activation (GO:0045576)2.71007171
111mRNA catabolic process (GO:0006402)2.70463110
112defense response to protozoan (GO:0042832)2.69956394
113translation (GO:0006412)2.69681228
114response to host defenses (GO:0052200)2.69124769
115response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.69124769
116response to protozoan (GO:0001562)2.69038065
117DNA strand elongation involved in DNA replication (GO:0006271)2.68238750
118interferon-gamma secretion (GO:0072643)2.64150640
119DNA strand elongation (GO:0022616)2.62151910
120lipoxygenase pathway (GO:0019372)2.61324951
121hepatocyte apoptotic process (GO:0097284)2.61128652
122antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58282184
123dendritic cell migration (GO:0036336)2.57378407
124mitotic recombination (GO:0006312)2.56662500
125interferon-gamma-mediated signaling pathway (GO:0060333)2.54737135
126dendritic cell chemotaxis (GO:0002407)2.54292105
127ribonucleoprotein complex biogenesis (GO:0022613)2.53928983
128T cell migration (GO:0072678)2.53335720
129regulation of B cell differentiation (GO:0045577)2.53191021
130positive regulation of B cell differentiation (GO:0045579)2.52208576
131deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.51499586
132RNA catabolic process (GO:0006401)2.51077174
133positive regulation of macrophage differentiation (GO:0045651)2.50519615
134positive regulation of interferon-alpha production (GO:0032727)2.47785174
135regulation of interferon-beta biosynthetic process (GO:0045357)2.45260507
136antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.44768183
137desmosome organization (GO:0002934)2.43962866
138sphingoid metabolic process (GO:0046519)2.43798975
139leukotriene metabolic process (GO:0006691)2.43260837
140actin nucleation (GO:0045010)2.43073594
141regulation of T cell receptor signaling pathway (GO:0050856)2.43023306
142positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.41344097
143* myeloid dendritic cell activation (GO:0001773)2.39537582
144response to interferon-alpha (GO:0035455)2.39444486
145detection of bacterium (GO:0016045)2.38206161
146positive regulation by organism of defense response of other organism involved in symbiotic interact2.36490580
147modulation by symbiont of host immune response (GO:0052553)2.36490580
148positive regulation by symbiont of host defense response (GO:0052509)2.36490580
149modulation by symbiont of host defense response (GO:0052031)2.36490580
150modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.36490580
151modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.36490580
152regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.35751660
153response to muramyl dipeptide (GO:0032495)2.33912760
154regulation of interferon-alpha production (GO:0032647)2.33789495
155G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.32410384
156regulation of cellular extravasation (GO:0002691)2.31423547
157reactive oxygen species biosynthetic process (GO:1903409)2.31396023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.99882329
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.61734144
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.32941122
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.85539673
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.58637221
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23966701
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.81817458
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.81803269
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.64024510
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.60058851
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58394407
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.51245160
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37043499
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.34750745
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32305856
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26973468
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26696042
18* SPI1_23547873_ChIP-Seq_NB4_Human2.25343871
19* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23107682
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.20920460
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19250692
22* IRF8_27001747_Chip-Seq_BMDM_Mouse2.19055689
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14826019
24SPI1_23127762_ChIP-Seq_K562_Human2.06873607
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06680095
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05585970
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03578085
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00357575
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98348267
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91374766
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89959808
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.89183204
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85884273
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84740126
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.82459069
36SCL_19346495_ChIP-Seq_HPC-7_Human1.76189021
37BCL6_27268052_Chip-Seq_Bcells_Human1.69101071
38VDR_23849224_ChIP-Seq_CD4+_Human1.67717214
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.67383938
40MYB_26560356_Chip-Seq_TH2_Human1.66594267
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65546172
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64511086
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60879913
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60716045
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59716123
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.59045299
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57195513
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54904849
49VDR_21846776_ChIP-Seq_THP-1_Human1.54572412
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.54184502
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.54060572
52* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53831736
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49586279
54GATA3_27048872_Chip-Seq_THYMUS_Human1.48730178
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47717392
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.47009717
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.46582119
58BCOR_27268052_Chip-Seq_Bcells_Human1.45594648
59MAF_26560356_Chip-Seq_TH1_Human1.44711344
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42866136
61LXR_22292898_ChIP-Seq_THP-1_Human1.41500035
62FOXP3_21729870_ChIP-Seq_TREG_Human1.40687886
63ELK1_19687146_ChIP-ChIP_HELA_Human1.40173790
64* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39868505
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38983546
66VDR_24763502_ChIP-Seq_THP-1_Human1.37927206
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37386463
68* MYB_26560356_Chip-Seq_TH1_Human1.36263290
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34894246
70GATA1_22025678_ChIP-Seq_K562_Human1.33362996
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.32932910
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28764135
73XRN2_22483619_ChIP-Seq_HELA_Human1.28242103
74VDR_24787735_ChIP-Seq_THP-1_Human1.27976250
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27273740
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26611954
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26081783
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25008987
79CIITA_25753668_ChIP-Seq_RAJI_Human1.24946681
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24505662
81DCP1A_22483619_ChIP-Seq_HELA_Human1.23206183
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22497101
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22381550
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21838552
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20153624
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19431817
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.19239682
88UTX_26944678_Chip-Seq_JUKART_Human1.18810315
89TCF7_22412390_ChIP-Seq_EML_Mouse1.17800476
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.16655008
91MYC_22102868_ChIP-Seq_BL_Human1.16187672
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15893719
93TTF2_22483619_ChIP-Seq_HELA_Human1.15624590
94P68_20966046_ChIP-Seq_HELA_Human1.14263024
95SRF_21415370_ChIP-Seq_HL-1_Mouse1.14111537
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14004664
97E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13480647
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13238689
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13058065
100RUNX_20019798_ChIP-Seq_JUKART_Human1.12859762
101P300_27268052_Chip-Seq_Bcells_Human1.12317565
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11361692
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11086358
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10755980
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09832680
106SPI1_20517297_ChIP-Seq_HL60_Human1.09137835
107NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08663112
108PU_27001747_Chip-Seq_BMDM_Mouse1.08418300
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06700036
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05708144
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05299300
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04713957
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04432865
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04330538
115KDM2B_26808549_Chip-Seq_DND41_Human1.04160919
116E2F1_20622854_ChIP-Seq_HELA_Human1.03132075
117* CTCF_26484167_Chip-Seq_Bcells_Mouse1.02137427
118E2F1_21310950_ChIP-Seq_MCF-7_Human1.01060919
119SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00634521
120STAT1_20625510_ChIP-Seq_HELA_Human1.00515204
121HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00402442
122MAF_26560356_Chip-Seq_TH2_Human0.99082860
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98530583
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98092713
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97030845
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96309760
127FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95146213
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94724213
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94649802
130YY1_22570637_ChIP-Seq_MALME-3M_Human0.94350930
131CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94291762
132CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93853079
133CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93029466
134GATA1_19941826_ChIP-Seq_K562_Human0.92629594
135RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92461787
136MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92267478
137ELK1_22589737_ChIP-Seq_MCF10A_Human0.91664082
138RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90800498
139GATA3_26560356_Chip-Seq_TH2_Human0.85975451
140* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85205097
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85103945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.05754425
2* MP0002148_abnormal_hypersensitivity_rea3.15886487
3MP0009785_altered_susceptibility_to3.01411871
4MP0003436_decreased_susceptibility_to2.93951108
5MP0005671_abnormal_response_to2.91849509
6MP0003724_increased_susceptibility_to2.69576261
7MP0005000_abnormal_immune_tolerance2.64126738
8* MP0005025_abnormal_response_to2.62589970
9MP0003763_abnormal_thymus_physiology2.52274580
10MP0000685_abnormal_immune_system2.48099186
11MP0001800_abnormal_humoral_immune2.35902499
12* MP0002419_abnormal_innate_immunity2.33604379
13* MP0002452_abnormal_antigen_presenting2.33239423
14MP0009379_abnormal_foot_pigmentation2.33200284
15MP0002166_altered_tumor_susceptibility2.32739261
16MP0002006_tumorigenesis2.30791843
17MP0001790_abnormal_immune_system2.24999277
18MP0005387_immune_system_phenotype2.24999277
19MP0003806_abnormal_nucleotide_metabolis2.23051758
20MP0003172_abnormal_lysosome_physiology2.21888073
21* MP0002420_abnormal_adaptive_immunity2.21737725
22* MP0001819_abnormal_immune_cell2.21357020
23MP0010155_abnormal_intestine_physiology2.21341444
24* MP0002723_abnormal_immune_serum2.21255015
25MP0002396_abnormal_hematopoietic_system2.19101393
26MP0000490_abnormal_crypts_of2.16801507
27MP0005174_abnormal_tail_pigmentation2.04440810
28MP0003693_abnormal_embryo_hatching1.94675956
29MP0004381_abnormal_hair_follicle1.92707069
30MP0006082_CNS_inflammation1.92592996
31MP0002405_respiratory_system_inflammati1.85390098
32MP0002398_abnormal_bone_marrow1.85142077
33MP0005464_abnormal_platelet_physiology1.83939948
34MP0004947_skin_inflammation1.83632549
35MP0001873_stomach_inflammation1.82944156
36MP0009333_abnormal_splenocyte_physiolog1.82056594
37MP0003183_abnormal_peptide_metabolism1.81486209
38MP0001853_heart_inflammation1.74109217
39* MP0000716_abnormal_immune_system1.73539221
40MP0003075_altered_response_to1.62139513
41* MP0001845_abnormal_inflammatory_respons1.59411135
42MP0002132_abnormal_respiratory_system1.58141968
43MP0003866_abnormal_defecation1.55544906
44MP0005397_hematopoietic_system_phenotyp1.55344582
45MP0001545_abnormal_hematopoietic_system1.55344582
46MP0002722_abnormal_immune_system1.55052677
47MP0003941_abnormal_skin_development1.51209209
48MP0000465_gastrointestinal_hemorrhage1.50471343
49MP0000689_abnormal_spleen_morphology1.50239553
50* MP0002429_abnormal_blood_cell1.49316846
51MP0002796_impaired_skin_barrier1.48524466
52MP0005075_abnormal_melanosome_morpholog1.45785252
53MP0000858_altered_metastatic_potential1.45108561
54MP0010094_abnormal_chromosome_stability1.42440630
55MP0008004_abnormal_stomach_pH1.39932125
56MP0002009_preneoplasia1.34684600
57MP0001533_abnormal_skeleton_physiology1.33551483
58MP0008057_abnormal_DNA_replication1.32087744
59MP0002277_abnormal_respiratory_mucosa1.29590395
60MP0004957_abnormal_blastocyst_morpholog1.29372406
61MP0001216_abnormal_epidermal_layer1.24202166
62MP0002095_abnormal_skin_pigmentation1.24105989
63MP0000703_abnormal_thymus_morphology1.20801577
64MP0003453_abnormal_keratinocyte_physiol1.20067899
65MP0003448_altered_tumor_morphology1.19200710
66MP0003828_pulmonary_edema1.16523343
67MP0004808_abnormal_hematopoietic_stem1.15034946
68MP0010352_gastrointestinal_tract_polyps1.14379869
69MP0008007_abnormal_cellular_replicative1.14298063
70* MP0008469_abnormal_protein_level1.14112509
71MP0003077_abnormal_cell_cycle1.13378622
72MP0008058_abnormal_DNA_repair1.11993935
73MP0005501_abnormal_skin_physiology1.11956169
74MP0009840_abnormal_foam_cell1.09702054
75MP0005058_abnormal_lysosome_morphology1.08213149
76MP0008260_abnormal_autophagy1.06938451
77MP0009764_decreased_sensitivity_to1.05815814
78MP0003303_peritoneal_inflammation1.05254416
79MP0003111_abnormal_nucleus_morphology1.04225875
80MP0004782_abnormal_surfactant_physiolog1.01601445
81MP0002019_abnormal_tumor_incidence1.00355511
82MP0003186_abnormal_redox_activity0.98910451
83MP0002060_abnormal_skin_morphology0.98276140
84MP0004883_abnormal_blood_vessel0.95312047
85MP0000015_abnormal_ear_pigmentation0.94568079
86MP0003300_gastrointestinal_ulcer0.92241372
87MP0002098_abnormal_vibrissa_morphology0.92126078
88MP0001851_eye_inflammation0.92012617
89MP0000343_altered_response_to0.91757970
90MP0003191_abnormal_cellular_cholesterol0.91240392
91MP0005310_abnormal_salivary_gland0.90025908
92MP0002933_joint_inflammation0.89080776
93MP0001663_abnormal_digestive_system0.88368048
94MP0000383_abnormal_hair_follicle0.87060470
95MP0000604_amyloidosis0.85767239
96MP0001191_abnormal_skin_condition0.84313835
97MP0005083_abnormal_biliary_tract0.83283200
98MP0005319_abnormal_enzyme/_coenzyme0.81805464
99MP0002254_reproductive_system_inflammat0.80684013
100MP0009765_abnormal_xenobiotic_induced0.80530793
101MP0005451_abnormal_body_composition0.79193317
102MP0005164_abnormal_response_to0.79027145
103MP0002998_abnormal_bone_remodeling0.77534202
104MP0004510_myositis0.77218670
105MP0005360_urolithiasis0.76456290
106MP0003786_premature_aging0.76102530
107MP0006054_spinal_hemorrhage0.75743871
108MP0001986_abnormal_taste_sensitivity0.75521269
109MP0009931_abnormal_skin_appearance0.73082420
110MP0000477_abnormal_intestine_morphology0.72028239
111MP0009278_abnormal_bone_marrow0.70436939
112MP0009763_increased_sensitivity_to0.69472988
113MP0000249_abnormal_blood_vessel0.68863681
114MP0002138_abnormal_hepatobiliary_system0.68813592
115MP0005390_skeleton_phenotype0.68527168
116MP0005166_decreased_susceptibility_to0.67553778
117MP0005165_increased_susceptibility_to0.65966065
118MP0003795_abnormal_bone_structure0.63023258
119MP0006036_abnormal_mitochondrial_physio0.61328777
120MP0003045_fibrosis0.61018300
121MP0008873_increased_physiological_sensi0.60205930
122MP0005584_abnormal_enzyme/coenzyme_acti0.58551134
123MP0009643_abnormal_urine_homeostasis0.58060627
124MP0003690_abnormal_glial_cell0.56076751
125MP0005381_digestive/alimentary_phenotyp0.54576896
126MP0005084_abnormal_gallbladder_morpholo0.54408624
127MP0002136_abnormal_kidney_physiology0.49525103
128MP0001542_abnormal_bone_strength0.49377546

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.97060750
2Abnormality of cells of the erythroid lineage (HP:0012130)4.63512800
3Eczematoid dermatitis (HP:0000976)4.63448194
4Reticulocytopenia (HP:0001896)4.51745348
5Abnormal number of erythroid precursors (HP:0012131)4.47755554
6Recurrent bacterial skin infections (HP:0005406)4.41997918
7Elevated erythrocyte sedimentation rate (HP:0003565)4.03417404
8Myositis (HP:0100614)3.92620627
9Abnormality of glycolipid metabolism (HP:0010969)3.62855390
10Abnormality of liposaccharide metabolism (HP:0010968)3.62855390
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.62855390
12Pustule (HP:0200039)3.58939651
13Thrombocytosis (HP:0001894)3.46301679
14Agammaglobulinemia (HP:0004432)3.38484504
15Increased cerebral lipofuscin (HP:0011813)3.34512937
16Recurrent fungal infections (HP:0002841)3.29305451
17Chest pain (HP:0100749)3.27355849
18Recurrent gram-negative bacterial infections (HP:0005420)3.27301202
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.23239974
20Pallor (HP:0000980)3.16340533
21IgM deficiency (HP:0002850)3.15395324
22Orchitis (HP:0100796)3.15302769
23Chronic obstructive pulmonary disease (HP:0006510)3.14926765
24Obstructive lung disease (HP:0006536)3.14926765
25Mediastinal lymphadenopathy (HP:0100721)3.14215182
26Retrobulbar optic neuritis (HP:0100654)3.09785746
27Optic neuritis (HP:0100653)3.09785746
28Epistaxis (HP:0000421)3.02363823
29Macrocytic anemia (HP:0001972)3.01268015
30Recurrent viral infections (HP:0004429)3.01227756
31Gastrointestinal infarctions (HP:0005244)3.00365559
32Abnormality of macrophages (HP:0004311)3.00243052
33Vacuolated lymphocytes (HP:0001922)2.95559305
34Chronic otitis media (HP:0000389)2.87555080
35Recurrent skin infections (HP:0001581)2.84161471
36Petechiae (HP:0000967)2.84016074
37Spontaneous hematomas (HP:0007420)2.80738665
38Meningitis (HP:0001287)2.74087202
39Purpura (HP:0000979)2.60640085
40Gingival bleeding (HP:0000225)2.58586562
41Periodontitis (HP:0000704)2.58251518
42Gingivitis (HP:0000230)2.57957987
43Gastrointestinal inflammation (HP:0004386)2.57671962
44Dysostosis multiplex (HP:0000943)2.56848930
45Autoimmune thrombocytopenia (HP:0001973)2.56490435
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55930774
47Stomatitis (HP:0010280)2.53800138
48Prostate neoplasm (HP:0100787)2.51874204
49Autoimmune hemolytic anemia (HP:0001890)2.50579416
50Abnormality of T cells (HP:0002843)2.50266429
51Abnormality of T cell number (HP:0011839)2.50173914
52Skin rash (HP:0000988)2.48716139
53Aplastic anemia (HP:0001915)2.48624833
54T lymphocytopenia (HP:0005403)2.47614255
55Recurrent cutaneous fungal infections (HP:0011370)2.47518774
56Chronic mucocutaneous candidiasis (HP:0002728)2.47518774
57Arterial thrombosis (HP:0004420)2.47391039
58Exertional dyspnea (HP:0002875)2.47171845
59Abnormality of the pleura (HP:0002103)2.46763272
60Agnosia (HP:0010524)2.45067339
61Recurrent bronchitis (HP:0002837)2.44214192
62Hepatosplenomegaly (HP:0001433)2.44134665
63Amyloidosis (HP:0011034)2.41357649
64Increased serum ferritin (HP:0003281)2.41308394
65Vasculitis (HP:0002633)2.40856381
66Abnormality of T cell physiology (HP:0011840)2.39728485
67Pulmonary embolism (HP:0002204)2.39471833
68Abnormality of the prostate (HP:0008775)2.36476073
69Cellulitis (HP:0100658)2.33394148
70Granulocytopenia (HP:0001913)2.31995193
71Loss of speech (HP:0002371)2.31089936
72Anorexia (HP:0002039)2.30963362
73Abnormal hemoglobin (HP:0011902)2.29669716
74Increased IgE level (HP:0003212)2.28898316
75Erythema (HP:0010783)2.28368353
76Colitis (HP:0002583)2.27731254
77Severe combined immunodeficiency (HP:0004430)2.27421514
78Urticaria (HP:0001025)2.27340090
79Eosinophilia (HP:0001880)2.25141035
80IgG deficiency (HP:0004315)2.24520068
81Type I transferrin isoform profile (HP:0003642)2.24489074
82Amaurosis fugax (HP:0100576)2.24279462
83Systemic lupus erythematosus (HP:0002725)2.23771167
84Leukocytosis (HP:0001974)2.23740946
8511 pairs of ribs (HP:0000878)2.23339457
86Osteomyelitis (HP:0002754)2.22966707
87Pulmonary fibrosis (HP:0002206)2.21526848
88Reduced antithrombin III activity (HP:0001976)2.20263055
89Combined immunodeficiency (HP:0005387)2.17853421
90Increased hepatocellular lipid droplets (HP:0006565)2.17518286
91Gangrene (HP:0100758)2.15113504
92Abnormality of iron homeostasis (HP:0011031)2.14527796
93Hypochromic anemia (HP:0001931)2.13727874
94Cheilitis (HP:0100825)2.13660261
95Prolonged bleeding time (HP:0003010)2.13176243
96Recurrent pneumonia (HP:0006532)2.11534689
97Keratoconjunctivitis sicca (HP:0001097)2.11386315
98Encephalitis (HP:0002383)2.10524887
99Skin ulcer (HP:0200042)2.10183053
100Basal ganglia calcification (HP:0002135)2.09911136
101Lymphoma (HP:0002665)2.07063775
102Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06968243
103Poikiloderma (HP:0001029)2.06919729
104B lymphocytopenia (HP:0010976)2.06867361
105Abnormality of B cell number (HP:0010975)2.06867361
106Hypergammaglobulinemia (HP:0010702)2.06850077
107Hypertensive crisis (HP:0100735)2.05952841
108Recurrent sinusitis (HP:0011108)2.05068023
109Abnormality of the preputium (HP:0100587)2.04707868
110Chromsome breakage (HP:0040012)2.04611175
111Panhypogammaglobulinemia (HP:0003139)2.04069204
112Lymphopenia (HP:0001888)2.03864235
113Hemoptysis (HP:0002105)2.03628910
114Abnormality of cells of the lymphoid lineage (HP:0012140)2.02673571
115Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01464082
116Abnormality of eosinophils (HP:0001879)1.98693227
117Polyneuropathy (HP:0001271)1.98091057
118Thrombophlebitis (HP:0004418)1.98014635
119Sparse eyelashes (HP:0000653)1.97990700
120Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96502058
121Glomerulopathy (HP:0100820)1.96062351
122Sepsis (HP:0100806)1.95450995
123Chronic diarrhea (HP:0002028)1.95440645
124Inflammation of the large intestine (HP:0002037)1.95286744
125Keratoconjunctivitis (HP:0001096)1.94763384
126Abnormality of the pericardium (HP:0001697)1.94113146
127Abnormality of polysaccharide metabolism (HP:0011012)1.94072334
128Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94072334
129Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94072334
130Thyroiditis (HP:0100646)1.93115855
131Increased IgM level (HP:0003496)1.90287708
132Respiratory difficulties (HP:0002880)1.90003802
133Abnormal delayed hypersensitivity skin test (HP:0002963)1.88392257
134Parakeratosis (HP:0001036)1.86918967
135Premature loss of primary teeth (HP:0006323)1.85214890
136Anhidrosis (HP:0000970)1.85158498
137Recurrent lower respiratory tract infections (HP:0002783)1.83896167
138Pulmonary infiltrates (HP:0002113)1.83351993
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82266346
140Lip pit (HP:0100267)1.81410384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.45875743
2BLK3.38821174
3MAP4K13.16872130
4IRAK42.94777268
5MAP3K142.72449610
6TXK2.64107894
7PIM22.55903033
8MST42.37058955
9TEC2.18299229
10IRAK32.14558424
11TYK22.14408137
12PBK2.05332471
13IKBKE2.04813137
14TNK22.02998784
15BCKDK1.97401009
16TBK11.89148163
17EIF2AK11.84546311
18BTK1.83998635
19KIT1.83900857
20IKBKB1.80042050
21TLK11.80012593
22JAK31.72838987
23RIPK41.66817000
24RPS6KA41.64961485
25ZAP701.60139274
26VRK21.53267719
27VRK11.53157697
28MST1R1.44869086
29CDK191.43633008
30STK101.42048555
31EIF2AK21.40645240
32SYK1.39169325
33EIF2AK31.34959824
34TGFBR21.31799779
35STK161.31232599
36ACVR1B1.30945661
37PIM11.27832919
38FGR1.15303271
39STK241.13639051
40RPS6KB21.13515516
41CSF1R1.13424501
42ITK1.11163206
43LYN1.10595177
44BUB11.10139506
45LCK1.08376683
46MAP3K131.06038355
47NEK91.04987829
48MAPKAPK31.03244238
49MAP2K61.02049952
50MAP3K31.01897125
51WEE11.00706767
52STK41.00308155
53CLK10.99536388
54YES10.97664818
55MAP3K110.96917276
56MAP3K120.94573756
57NLK0.93110319
58GRK70.89647068
59LRRK20.88531650
60NUAK10.87287106
61MAP3K10.86802879
62HCK0.86335848
63JAK10.84785474
64ADRBK20.83889258
65SCYL20.82474355
66TRPM70.81554101
67CHUK0.81384503
68TAOK10.80136649
69CSK0.77329674
70TAOK20.77263966
71MAP2K30.76979493
72TAOK30.75806784
73PRKCQ0.75624026
74AURKB0.75427926
75SMG10.75269159
76ZAK0.75139262
77KDR0.74658904
78ERN10.73318610
79PRPF4B0.70082463
80PDK10.69369845
81TGFBR10.66111759
82FLT30.65832868
83GRK60.65730617
84ATR0.61978590
85SRPK10.60880151
86PLK40.60284011
87FYN0.60169914
88MATK0.58786759
89MAPKAPK20.57075087
90PDPK10.56811661
91BMPR20.55170715
92RPS6KA60.53832664
93PRKD20.53079168
94NEK20.52961769
95MARK30.51831927
96CDK70.51634272
97TESK10.51214727
98BRSK20.50767928
99ARAF0.50728668
100CDC70.50584600
101DYRK30.50151382
102PRKCD0.48884014
103ABL20.48646674
104JAK20.48280282
105PIK3CG0.47708619
106RPS6KA50.47372477
107PRKG20.47147883
108ABL10.46961024
109RPS6KC10.46901885
110RPS6KL10.46901885
111DAPK10.46305751
112MAPK70.44513749
113MAPK120.43517942
114FES0.42929782
115BMPR1B0.42499272
116HIPK20.42119017
117GRK10.41616824
118CDK40.40994125
119TESK20.40697132
120MAP2K20.38711119
121CDK80.38582353
122MKNK10.36704279
123IRAK10.36251775
124CSNK2A10.35752902
125MAPK40.35517993
126CDK60.35371321
127MAPK110.34835810
128IRAK20.29452722
129MAP3K50.28082131
130EPHB10.28076154
131IGF1R0.26001235
132MAP3K60.25181073
133MAPK30.24597839
134ADRBK10.21914528
135PTK60.21815117
136PRKD10.21194746
137RPS6KA20.20845145
138GRK50.20788717

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.58322348
2DNA replication_Homo sapiens_hsa030303.10058834
3* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.55994764
4Mismatch repair_Homo sapiens_hsa034302.38448466
5Leishmaniasis_Homo sapiens_hsa051402.31486654
6Primary immunodeficiency_Homo sapiens_hsa053402.28638174
7Proteasome_Homo sapiens_hsa030502.20313326
8Graft-versus-host disease_Homo sapiens_hsa053322.13402085
9Homologous recombination_Homo sapiens_hsa034402.08248958
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99418084
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.96601601
12Base excision repair_Homo sapiens_hsa034101.91149162
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.83154443
14Antigen processing and presentation_Homo sapiens_hsa046121.76024581
15Other glycan degradation_Homo sapiens_hsa005111.73862970
16Measles_Homo sapiens_hsa051621.69194731
17Allograft rejection_Homo sapiens_hsa053301.67453552
18Hematopoietic cell lineage_Homo sapiens_hsa046401.65219869
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64267384
20Herpes simplex infection_Homo sapiens_hsa051681.59109638
21Staphylococcus aureus infection_Homo sapiens_hsa051501.59098555
22RNA polymerase_Homo sapiens_hsa030201.55733229
23* Legionellosis_Homo sapiens_hsa051341.51401022
24Pyrimidine metabolism_Homo sapiens_hsa002401.48946066
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48648593
26Nucleotide excision repair_Homo sapiens_hsa034201.46400248
27Osteoclast differentiation_Homo sapiens_hsa043801.41893677
28* Pertussis_Homo sapiens_hsa051331.41383860
29* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40307814
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39142577
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36160894
32Non-homologous end-joining_Homo sapiens_hsa034501.32398632
33Fanconi anemia pathway_Homo sapiens_hsa034601.28268936
34Spliceosome_Homo sapiens_hsa030401.27456277
35Tuberculosis_Homo sapiens_hsa051521.24580470
36* Influenza A_Homo sapiens_hsa051641.23049540
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18980559
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17984184
39Asthma_Homo sapiens_hsa053101.13778832
40Malaria_Homo sapiens_hsa051441.13206831
41Arachidonic acid metabolism_Homo sapiens_hsa005901.08759124
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08111300
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.05841837
44p53 signaling pathway_Homo sapiens_hsa041151.03578123
45Apoptosis_Homo sapiens_hsa042101.02889667
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00639627
47B cell receptor signaling pathway_Homo sapiens_hsa046620.99992961
48Toxoplasmosis_Homo sapiens_hsa051450.98100478
49Shigellosis_Homo sapiens_hsa051310.93938909
50* Salmonella infection_Homo sapiens_hsa051320.91296078
51Autoimmune thyroid disease_Homo sapiens_hsa053200.90664003
52Protein export_Homo sapiens_hsa030600.90565729
53Folate biosynthesis_Homo sapiens_hsa007900.90067439
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89834787
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.89684515
56TNF signaling pathway_Homo sapiens_hsa046680.86426924
57T cell receptor signaling pathway_Homo sapiens_hsa046600.83958142
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.82551746
59RNA degradation_Homo sapiens_hsa030180.81722610
60Sphingolipid metabolism_Homo sapiens_hsa006000.81567051
61Rheumatoid arthritis_Homo sapiens_hsa053230.78407851
62Epstein-Barr virus infection_Homo sapiens_hsa051690.78322452
63Oxidative phosphorylation_Homo sapiens_hsa001900.78040176
64Basal transcription factors_Homo sapiens_hsa030220.76744809
65One carbon pool by folate_Homo sapiens_hsa006700.76151060
66Hepatitis B_Homo sapiens_hsa051610.75734659
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75019701
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73486676
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72086512
70Cell cycle_Homo sapiens_hsa041100.71031458
71Systemic lupus erythematosus_Homo sapiens_hsa053220.70724991
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70629977
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70499466
74Hepatitis C_Homo sapiens_hsa051600.67789863
75Lysosome_Homo sapiens_hsa041420.67532940
76Chemokine signaling pathway_Homo sapiens_hsa040620.65659790
77Parkinsons disease_Homo sapiens_hsa050120.64449424
78Viral myocarditis_Homo sapiens_hsa054160.64342505
79Pentose phosphate pathway_Homo sapiens_hsa000300.63139426
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60781936
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60704285
82Type I diabetes mellitus_Homo sapiens_hsa049400.59883626
83RNA transport_Homo sapiens_hsa030130.59296036
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58858000
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58245053
86Phagosome_Homo sapiens_hsa041450.58226267
87Purine metabolism_Homo sapiens_hsa002300.57665269
88Collecting duct acid secretion_Homo sapiens_hsa049660.56425064
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56058344
90Acute myeloid leukemia_Homo sapiens_hsa052210.56039672
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51375746
92Platelet activation_Homo sapiens_hsa046110.50984153
93Huntingtons disease_Homo sapiens_hsa050160.50729592
94African trypanosomiasis_Homo sapiens_hsa051430.49924195
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49752578
96HTLV-I infection_Homo sapiens_hsa051660.48273717
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.46160245
98Viral carcinogenesis_Homo sapiens_hsa052030.44958873
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.44851145
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40972866
101Glutathione metabolism_Homo sapiens_hsa004800.40067250
102Alzheimers disease_Homo sapiens_hsa050100.39962837
103Linoleic acid metabolism_Homo sapiens_hsa005910.39804108
104Galactose metabolism_Homo sapiens_hsa000520.38512137
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.37281459
106Caffeine metabolism_Homo sapiens_hsa002320.37236016
107Renin-angiotensin system_Homo sapiens_hsa046140.36960644
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33788194
109Endocytosis_Homo sapiens_hsa041440.31825653
110Sulfur metabolism_Homo sapiens_hsa009200.31804890
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30662038
112Vitamin digestion and absorption_Homo sapiens_hsa049770.30352384
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.29323834
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27530662
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24992675
116Non-small cell lung cancer_Homo sapiens_hsa052230.22177898
117Regulation of autophagy_Homo sapiens_hsa041400.22005345
118Ether lipid metabolism_Homo sapiens_hsa005650.21353283
119Peroxisome_Homo sapiens_hsa041460.17467882
120Amoebiasis_Homo sapiens_hsa051460.16431304
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15542173
122VEGF signaling pathway_Homo sapiens_hsa043700.12570143
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.12035834
124Fructose and mannose metabolism_Homo sapiens_hsa000510.08377736
125Pancreatic cancer_Homo sapiens_hsa052120.08235160

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