PYCR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.57666459
2negative regulation of erythrocyte differentiation (GO:0045647)5.05213721
3formation of translation preinitiation complex (GO:0001731)4.79271027
4telomere maintenance via semi-conservative replication (GO:0032201)4.72981313
5DNA strand elongation involved in DNA replication (GO:0006271)4.72776171
6ribosomal small subunit assembly (GO:0000028)4.62074602
7DNA strand elongation (GO:0022616)4.49571192
8folic acid-containing compound biosynthetic process (GO:0009396)4.31018919
9viral transcription (GO:0019083)4.14419312
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.09496393
11translational termination (GO:0006415)4.05608400
12DNA replication initiation (GO:0006270)4.03665708
13cotranslational protein targeting to membrane (GO:0006613)3.99309062
14protein targeting to ER (GO:0045047)3.98941860
15telomere maintenance via recombination (GO:0000722)3.98939849
16maturation of SSU-rRNA (GO:0030490)3.92923875
17ribosomal small subunit biogenesis (GO:0042274)3.85620352
18ribosomal large subunit biogenesis (GO:0042273)3.83289416
19DNA unwinding involved in DNA replication (GO:0006268)3.81517424
20nucleotide-excision repair, DNA gap filling (GO:0006297)3.80304992
21translational elongation (GO:0006414)3.78933871
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.78655787
23translational initiation (GO:0006413)3.75376028
24protein localization to endoplasmic reticulum (GO:0070972)3.72940595
25pseudouridine synthesis (GO:0001522)3.72406039
26IMP biosynthetic process (GO:0006188)3.70106563
27nucleobase biosynthetic process (GO:0046112)3.68818620
28ribonucleoprotein complex biogenesis (GO:0022613)3.66614899
29ribosome biogenesis (GO:0042254)3.63699723
30telomere maintenance via telomere lengthening (GO:0010833)3.62203176
31mitotic recombination (GO:0006312)3.55439900
32proteasome assembly (GO:0043248)3.53054853
33protoporphyrinogen IX metabolic process (GO:0046501)3.52003305
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46031543
35pteridine-containing compound biosynthetic process (GO:0042559)3.44741922
36positive regulation of gamma-delta T cell activation (GO:0046645)3.43855134
37establishment of integrated proviral latency (GO:0075713)3.43696036
38DNA replication checkpoint (GO:0000076)3.41212727
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.41041330
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.41041330
41rRNA processing (GO:0006364)3.39814287
42GDP-mannose metabolic process (GO:0019673)3.38873918
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.37356350
443-UTR-mediated mRNA stabilization (GO:0070935)3.35117451
45viral mRNA export from host cell nucleus (GO:0046784)3.33055189
46transcription-coupled nucleotide-excision repair (GO:0006283)3.31662909
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.31463095
48antigen processing and presentation of endogenous antigen (GO:0019883)3.31357506
49spliceosomal snRNP assembly (GO:0000387)3.31226023
50translation (GO:0006412)3.31141564
51purine nucleobase biosynthetic process (GO:0009113)3.30757533
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29622438
53rRNA metabolic process (GO:0016072)3.28824435
54regulation of gene silencing by RNA (GO:0060966)3.28220394
55regulation of posttranscriptional gene silencing (GO:0060147)3.28220394
56regulation of gene silencing by miRNA (GO:0060964)3.28220394
57viral life cycle (GO:0019058)3.24241571
58positive regulation of B cell differentiation (GO:0045579)3.17749280
59cellular protein complex disassembly (GO:0043624)3.17527151
60pentose-phosphate shunt (GO:0006098)3.16444188
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15368152
62DNA replication-dependent nucleosome assembly (GO:0006335)3.12720239
63DNA replication-dependent nucleosome organization (GO:0034723)3.12720239
64ribosome assembly (GO:0042255)3.12117927
65IMP metabolic process (GO:0046040)3.11967214
66mitotic chromosome condensation (GO:0007076)3.10536007
67base-excision repair (GO:0006284)3.09957090
68termination of RNA polymerase III transcription (GO:0006386)3.09708567
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.09708567
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09165634
71maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05453755
72maturation of 5.8S rRNA (GO:0000460)3.04527722
73rRNA modification (GO:0000154)3.03797235
74regulation of nuclear cell cycle DNA replication (GO:0033262)3.01903168
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98897344
76L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95964724
77oxygen transport (GO:0015671)2.95894544
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92602908
79protein complex disassembly (GO:0043241)2.92547973
80termination of RNA polymerase II transcription (GO:0006369)2.92365565
81regulation of chromatin binding (GO:0035561)2.91903294
82* proline biosynthetic process (GO:0006561)2.91861474
83neutrophil activation involved in immune response (GO:0002283)2.91243718
84spliceosomal complex assembly (GO:0000245)2.91056430
85replication fork processing (GO:0031297)2.89976878
86nuclear-transcribed mRNA catabolic process (GO:0000956)2.89110511
87spliceosomal tri-snRNP complex assembly (GO:0000244)2.87723608
88mitotic nuclear envelope disassembly (GO:0007077)2.86332817
89negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.85384621
90megakaryocyte development (GO:0035855)2.83529977
91mitochondrial DNA metabolic process (GO:0032042)2.83109739
92cellular component biogenesis (GO:0044085)2.81843264
93thymic T cell selection (GO:0045061)2.81437521
94cullin deneddylation (GO:0010388)2.81297587
95regulation of translational fidelity (GO:0006450)2.80512735
96macromolecular complex disassembly (GO:0032984)2.79957187
97gas transport (GO:0015669)2.79518323
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78317131
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78317131
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.76657326
101tRNA methylation (GO:0030488)2.75951422
102protoporphyrinogen IX biosynthetic process (GO:0006782)2.75932080
103RNA catabolic process (GO:0006401)2.74967128
104positive thymic T cell selection (GO:0045059)2.74924151
105mRNA catabolic process (GO:0006402)2.74640368
106Golgi transport vesicle coating (GO:0048200)2.74031352
107COPI coating of Golgi vesicle (GO:0048205)2.74031352
108ncRNA processing (GO:0034470)2.73799146
109regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73763402
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73445751
111negative regulation of ligase activity (GO:0051352)2.72794182
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72794182
113positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72752749
114telomere organization (GO:0032200)2.72156116
115modulation by virus of host process (GO:0019054)2.71992685
116regulation of double-strand break repair via homologous recombination (GO:0010569)2.71280708
117RNA splicing, via transesterification reactions (GO:0000375)2.71234264
118mannose metabolic process (GO:0006013)2.70818271
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.70788430
120DNA-templated transcription, termination (GO:0006353)2.69619340
121G1/S transition of mitotic cell cycle (GO:0000082)2.68902913
122cell cycle G1/S phase transition (GO:0044843)2.68902913
123protein maturation by protein folding (GO:0022417)2.68444130
124peptidyl-arginine omega-N-methylation (GO:0035247)2.67359502
125regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67169263
126regulation of histone H3-K27 methylation (GO:0061085)2.65320566
127Peyers patch development (GO:0048541)2.64081071
128mucosal-associated lymphoid tissue development (GO:0048537)2.64081071
129cellular response to interleukin-4 (GO:0071353)2.62642851
130regulation of superoxide anion generation (GO:0032928)2.62077542
131regulation of early endosome to late endosome transport (GO:2000641)2.61583727
132antigen processing and presentation via MHC class Ib (GO:0002475)2.61376563
133Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60721074
134nuclear envelope reassembly (GO:0031468)2.59921971
135mitotic nuclear envelope reassembly (GO:0007084)2.59921971
136snRNA metabolic process (GO:0016073)2.59773406
137NADPH regeneration (GO:0006740)2.59386491
138glucose catabolic process (GO:0006007)2.59017926
139apoptotic process involved in morphogenesis (GO:0060561)2.58179692
140nuclear pore complex assembly (GO:0051292)2.57457940
141negative regulation of necroptotic process (GO:0060546)2.56455487
142poly(A)+ mRNA export from nucleus (GO:0016973)2.56343186
143positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.55820775
144nucleobase-containing small molecule interconversion (GO:0015949)2.54257729
145negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.54114669
146negative regulation of cell killing (GO:0031342)2.54114669
147regulation of translational termination (GO:0006449)2.53281492
148cellular hyperosmotic response (GO:0071474)2.52175612
149regulation of response to osmotic stress (GO:0047484)2.51250591
150pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.50760589
151B cell receptor signaling pathway (GO:0050853)2.50139121
152regulation of gamma-delta T cell differentiation (GO:0045586)2.49056490
153deoxyribose phosphate biosynthetic process (GO:0046385)2.48550566
1542-deoxyribonucleotide biosynthetic process (GO:0009265)2.48550566
155platelet formation (GO:0030220)2.48127541
156modulation by symbiont of host cellular process (GO:0044068)2.46541628
157folic acid metabolic process (GO:0046655)2.46520243
158DNA topological change (GO:0006265)2.46227105
159erythrocyte maturation (GO:0043249)2.44240102
160protein export from nucleus (GO:0006611)2.42886668
161pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.41726421
162positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.41717888
163retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37989430
164positive regulation of granulocyte differentiation (GO:0030854)2.36115785
165positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.35300478
166pinocytosis (GO:0006907)2.35103230
167regulation of gamma-delta T cell activation (GO:0046643)2.34014177
168heterochromatin organization (GO:0070828)2.32851619
169response to interleukin-4 (GO:0070670)2.31904734
170RNA stabilization (GO:0043489)2.29223955
171mRNA stabilization (GO:0048255)2.29223955
172protein-DNA complex disassembly (GO:0032986)2.28088225
173nucleosome disassembly (GO:0006337)2.28088225
174tolerance induction (GO:0002507)2.26606573
175NIK/NF-kappaB signaling (GO:0038061)2.25557778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.19906221
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.36335482
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77806104
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16597348
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07460876
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06478165
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.04832715
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03428735
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.97978037
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.92170450
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89002077
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80935744
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59545509
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57696689
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41744407
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36094087
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.35038327
18XRN2_22483619_ChIP-Seq_HELA_Human2.32237855
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31097710
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30714250
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25944681
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22376972
23VDR_23849224_ChIP-Seq_CD4+_Human2.19304699
24LXR_22292898_ChIP-Seq_THP-1_Human2.11508399
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10947831
26GABP_19822575_ChIP-Seq_HepG2_Human2.02989327
27DCP1A_22483619_ChIP-Seq_HELA_Human2.02738640
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.00388116
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.95214160
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90764288
31FOXP3_21729870_ChIP-Seq_TREG_Human1.90420992
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89080129
33* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86322200
34* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85803967
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85540919
36TTF2_22483619_ChIP-Seq_HELA_Human1.84611837
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83856939
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83462823
39MAF_26560356_Chip-Seq_TH1_Human1.80577492
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.76277998
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75231931
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74093908
43* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67921124
44* NCOR1_26117541_ChIP-Seq_K562_Human1.67255126
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66637924
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66552912
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64853962
48* TCF7_22412390_ChIP-Seq_EML_Mouse1.61629575
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61160954
50ZNF263_19887448_ChIP-Seq_K562_Human1.60846870
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.60157975
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58249382
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58206729
54MYC_22102868_ChIP-Seq_BL_Human1.57369468
55UTX_26944678_Chip-Seq_JUKART_Human1.56723988
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56139718
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55783216
58* RACK7_27058665_Chip-Seq_MCF-7_Human1.54404678
59VDR_24763502_ChIP-Seq_THP-1_Human1.53704075
60* MAF_26560356_Chip-Seq_TH2_Human1.53435021
61KDM2B_26808549_Chip-Seq_DND41_Human1.53342913
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53068254
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52300388
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50923711
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50678598
66* SRF_21415370_ChIP-Seq_HL-1_Mouse1.50503307
67* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49837700
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49025825
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48041732
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47707623
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.47011245
72* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46074842
73* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45000907
74* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45000907
75* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45000907
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43746098
77* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43584703
78CIITA_25753668_ChIP-Seq_RAJI_Human1.42278146
79ELK1_19687146_ChIP-ChIP_HELA_Human1.41857208
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40943742
81* P68_20966046_ChIP-Seq_HELA_Human1.39584467
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38837330
83TFEB_21752829_ChIP-Seq_HELA_Human1.38721137
84* KDM5A_27292631_Chip-Seq_BREAST_Human1.38619648
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37903311
86SCL_19346495_ChIP-Seq_HPC-7_Human1.37784981
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37750094
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36268032
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35201640
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35090412
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34439132
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.34423755
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33708452
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30250403
95* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29133571
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.29004961
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27369475
98* SA1_27219007_Chip-Seq_ERYTHROID_Human1.26347249
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25290166
100* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25235749
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24790465
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24008406
103VDR_21846776_ChIP-Seq_THP-1_Human1.23574311
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20918348
105* GATA1_19941826_ChIP-Seq_K562_Human1.19983291
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18616525
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18174799
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17231476
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15944577
110SPI1_23547873_ChIP-Seq_NB4_Human1.15617219
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15092438
112NOTCH1_21737748_ChIP-Seq_TLL_Human1.13425066
113TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13005963
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12638752
115RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11396815
116BCOR_27268052_Chip-Seq_Bcells_Human1.11360752
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10538638
118* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10325918
119AR_21909140_ChIP-Seq_LNCAP_Human1.09862371
120* GATA1_19941827_ChIP-Seq_MEL_Mouse1.07824770
121BCL6_27268052_Chip-Seq_Bcells_Human1.07296126
122E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06571029
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06361120
124PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05961385
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05771216
126SPI1_23127762_ChIP-Seq_K562_Human1.05745455
127* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05411647
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04876108
129KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04243727
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04202692
131KDM2B_26808549_Chip-Seq_JURKAT_Human1.04081200
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03502633
133* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03458935
134SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02995843
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02275324
136PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01650210
137* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01572767
138MYB_26560356_Chip-Seq_TH1_Human0.98564940
139ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97904318
140NANOG_21062744_ChIP-ChIP_HESCs_Human0.96852135
141SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95040554
142OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94283816
143ELK1_22589737_ChIP-Seq_MCF10A_Human0.94187298
144NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91792071
145YY1_22570637_ChIP-Seq_MALME-3M_Human0.91383718
146NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90246204
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89993615
148CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89874424
149SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89335191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.74938081
2MP0004957_abnormal_blastocyst_morpholog4.11591811
3MP0008057_abnormal_DNA_replication4.00951052
4MP0010094_abnormal_chromosome_stability3.87121594
5MP0008058_abnormal_DNA_repair3.56962826
6MP0003111_abnormal_nucleus_morphology3.55672626
7MP0005451_abnormal_body_composition3.27283821
8MP0003077_abnormal_cell_cycle3.25117875
9MP0003283_abnormal_digestive_organ3.21390539
10MP0005464_abnormal_platelet_physiology3.13701225
11MP0004133_heterotaxia2.88889492
12MP0003303_peritoneal_inflammation2.84004571
13MP0008932_abnormal_embryonic_tissue2.57151151
14MP0003436_decreased_susceptibility_to2.52031084
15MP0005058_abnormal_lysosome_morphology2.44399357
16MP0000685_abnormal_immune_system2.29508048
17MP0001835_abnormal_antigen_presentation2.29287200
18MP0008007_abnormal_cellular_replicative2.23301046
19MP0010352_gastrointestinal_tract_polyps2.16067027
20MP0010030_abnormal_orbit_morphology2.05201086
21MP0004185_abnormal_adipocyte_glucose2.01085067
22MP0003656_abnormal_erythrocyte_physiolo1.97267183
23MP0000490_abnormal_crypts_of1.96408163
24MP0005083_abnormal_biliary_tract1.89724224
25MP0001730_embryonic_growth_arrest1.89686162
26MP0003786_premature_aging1.85195017
27MP0005671_abnormal_response_to1.83150544
28MP0000350_abnormal_cell_proliferation1.81992869
29MP0008260_abnormal_autophagy1.81260335
30MP0003705_abnormal_hypodermis_morpholog1.78128023
31MP0003806_abnormal_nucleotide_metabolis1.77942718
32MP0000678_abnormal_parathyroid_gland1.77691826
33MP0002653_abnormal_ependyma_morphology1.75225888
34MP0005000_abnormal_immune_tolerance1.72406437
35MP0003119_abnormal_digestive_system1.71794635
36MP0003123_paternal_imprinting1.70398306
37MP0008877_abnormal_DNA_methylation1.67845980
38MP0001790_abnormal_immune_system1.66280275
39MP0005387_immune_system_phenotype1.66280275
40MP0001800_abnormal_humoral_immune1.63218148
41MP0004947_skin_inflammation1.62109459
42MP0002420_abnormal_adaptive_immunity1.59186396
43MP0003890_abnormal_embryonic-extraembry1.58882046
44MP0001819_abnormal_immune_cell1.57916962
45MP0001697_abnormal_embryo_size1.56934655
46MP0005025_abnormal_response_to1.56167380
47MP0002877_abnormal_melanocyte_morpholog1.55450550
48MP0002723_abnormal_immune_serum1.54205137
49MP0002085_abnormal_embryonic_tissue1.51069672
50MP0002452_abnormal_antigen_presenting1.49646073
51MP0000716_abnormal_immune_system1.49542694
52MP0005220_abnormal_exocrine_pancreas1.49241457
53MP0000313_abnormal_cell_death1.49094984
54MP0003300_gastrointestinal_ulcer1.48110974
55MP0002080_prenatal_lethality1.46935650
56MP0006292_abnormal_olfactory_placode1.46728276
57MP0003172_abnormal_lysosome_physiology1.46161806
58MP0006072_abnormal_retinal_apoptosis1.44997941
59MP0001293_anophthalmia1.44857123
60MP0002084_abnormal_developmental_patter1.41313394
61MP0002419_abnormal_innate_immunity1.41014937
62MP0001873_stomach_inflammation1.38690062
63MP0003763_abnormal_thymus_physiology1.35844314
64MP0001672_abnormal_embryogenesis/_devel1.33138937
65MP0005380_embryogenesis_phenotype1.33138937
66MP0003718_maternal_effect1.31497221
67MP0009333_abnormal_splenocyte_physiolog1.30748168
68MP0005666_abnormal_adipose_tissue1.30166632
69MP0005501_abnormal_skin_physiology1.29032309
70MP0002693_abnormal_pancreas_physiology1.28587905
71MP0002019_abnormal_tumor_incidence1.28533212
72MP0002396_abnormal_hematopoietic_system1.27131540
73MP0004858_abnormal_nervous_system1.24685942
74MP0003453_abnormal_keratinocyte_physiol1.23813461
75MP0010155_abnormal_intestine_physiology1.22701157
76MP0001849_ear_inflammation1.21729796
77MP0002148_abnormal_hypersensitivity_rea1.20530485
78MP0004197_abnormal_fetal_growth/weight/1.19349018
79MP0002160_abnormal_reproductive_system1.17816114
80MP0003566_abnormal_cell_adhesion1.17155913
81MP0000465_gastrointestinal_hemorrhage1.15024206
82MP0002086_abnormal_extraembryonic_tissu1.14305587
83MP0002132_abnormal_respiratory_system1.14273735
84MP0001944_abnormal_pancreas_morphology1.12240971
85MP0000358_abnormal_cell_content/1.11689796
86MP0002405_respiratory_system_inflammati1.11647197
87MP0003941_abnormal_skin_development1.11439085
88MP0000343_altered_response_to1.10436704
89MP0004264_abnormal_extraembryonic_tissu1.07632449
90MP0010307_abnormal_tumor_latency1.07376788
91MP0003984_embryonic_growth_retardation1.05925914
92MP0009840_abnormal_foam_cell1.05018418
93MP0004233_abnormal_muscle_weight1.04551306
94MP0005389_reproductive_system_phenotype1.04262817
95MP0000703_abnormal_thymus_morphology1.01189592
96MP0002088_abnormal_embryonic_growth/wei1.00833866
97MP0005075_abnormal_melanosome_morpholog0.99565944
98MP0003186_abnormal_redox_activity0.99342937
99MP0002111_abnormal_tail_morphology0.99232069
100MP0003191_abnormal_cellular_cholesterol0.98770728
101MP0001661_extended_life_span0.98211187
102MP0000462_abnormal_digestive_system0.96433183
103MP0001145_abnormal_male_reproductive0.94180046
104MP0000470_abnormal_stomach_morphology0.93474451
105MP0009278_abnormal_bone_marrow0.92702907
106MP0001845_abnormal_inflammatory_respons0.92613936
107MP0001853_heart_inflammation0.90848356
108MP0004510_myositis0.90569987
109MP0006035_abnormal_mitochondrial_morpho0.90450614
110MP0000613_abnormal_salivary_gland0.89050201
111MP0002751_abnormal_autonomic_nervous0.88068385
112MP0005397_hematopoietic_system_phenotyp0.87773673
113MP0001545_abnormal_hematopoietic_system0.87773673
114MP0009931_abnormal_skin_appearance0.85790148
115MP0002210_abnormal_sex_determination0.85673635
116MP0005375_adipose_tissue_phenotype0.83656641
117MP0001186_pigmentation_phenotype0.83420314
118MP0002796_impaired_skin_barrier0.83222741
119MP0004043_abnormal_pH_regulation0.82338913
120MP0001986_abnormal_taste_sensitivity0.80910681
121MP0000747_muscle_weakness0.80261495
122MP0002398_abnormal_bone_marrow0.80206725
123MP0000477_abnormal_intestine_morphology0.79398247
124MP0000689_abnormal_spleen_morphology0.78767288
125MP0002722_abnormal_immune_system0.78678906
126MP0005379_endocrine/exocrine_gland_phen0.78638902
127MP0002249_abnormal_larynx_morphology0.77154091
128MP0005384_cellular_phenotype0.76826973
129MP0006036_abnormal_mitochondrial_physio0.76597914
130MP0003828_pulmonary_edema0.75812255
131MP0005174_abnormal_tail_pigmentation0.75571173
132MP0003315_abnormal_perineum_morphology0.75508337
133MP0001533_abnormal_skeleton_physiology0.75477669
134MP0004381_abnormal_hair_follicle0.75428005
135MP0003121_genomic_imprinting0.75133535
136MP0009785_altered_susceptibility_to0.74702621
137MP0002075_abnormal_coat/hair_pigmentati0.74507490
138MP0009763_increased_sensitivity_to0.74476668
139MP0009672_abnormal_birth_weight0.74351639
140MP0003567_abnormal_fetal_cardiomyocyte0.73041359
141MP0000371_diluted_coat_color0.71926050
142MP0001348_abnormal_lacrimal_gland0.71727014
143MP0000653_abnormal_sex_gland0.70925654
144MP0002938_white_spotting0.70773490
145MP0001929_abnormal_gametogenesis0.70653531
146MP0001919_abnormal_reproductive_system0.68488058
147MP0005621_abnormal_cell_physiology0.66101283
148MP0008789_abnormal_olfactory_epithelium0.64165874
149MP0003866_abnormal_defecation0.63593012
150MP0005076_abnormal_cell_differentiation0.63307664
151MP0005171_absent_coat_pigmentation0.63171243
152MP0002429_abnormal_blood_cell0.63056106
153MP0004808_abnormal_hematopoietic_stem0.62966841
154MP0005266_abnormal_metabolism0.61289761
155MP0000015_abnormal_ear_pigmentation0.60576697
156MP0000858_altered_metastatic_potential0.58362521
157MP0001286_abnormal_eye_development0.56217806

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.25291363
2Reticulocytopenia (HP:0001896)4.16709964
3Birth length less than 3rd percentile (HP:0003561)4.10639977
4Abnormal number of erythroid precursors (HP:0012131)4.01585194
5Petechiae (HP:0000967)3.86031476
6Prolonged bleeding time (HP:0003010)3.77665209
7Aplasia/Hypoplasia of the sacrum (HP:0008517)3.74241077
8Abnormal gallbladder physiology (HP:0012438)3.58877144
9Cholecystitis (HP:0001082)3.58877144
10Hypertensive crisis (HP:0100735)3.47902538
11Reticulocytosis (HP:0001923)3.37911870
12Purpura (HP:0000979)3.32248208
13Breast hypoplasia (HP:0003187)3.31201520
14Type I transferrin isoform profile (HP:0003642)3.26161365
15Truncus arteriosus (HP:0001660)3.23061031
16Cerebral hypomyelination (HP:0006808)3.21452771
1711 pairs of ribs (HP:0000878)3.16757637
18Absent thumb (HP:0009777)3.13460391
19Intestinal atresia (HP:0011100)3.11675338
20Aplastic anemia (HP:0001915)3.08904248
21Nasal polyposis (HP:0100582)3.06314132
22Premature graying of hair (HP:0002216)3.05734376
23Degeneration of anterior horn cells (HP:0002398)3.05426983
24Abnormality of the anterior horn cell (HP:0006802)3.05426983
25Chronic obstructive pulmonary disease (HP:0006510)3.03941037
26Obstructive lung disease (HP:0006536)3.03941037
27Gastrointestinal stroma tumor (HP:0100723)2.93419857
28Absent radius (HP:0003974)2.92812385
29Hyperthyroidism (HP:0000836)2.87059586
30Rough bone trabeculation (HP:0100670)2.85791204
31Eczematoid dermatitis (HP:0000976)2.84714399
32Abnormality of reticulocytes (HP:0004312)2.84398389
33Cellulitis (HP:0100658)2.82776921
34Selective tooth agenesis (HP:0001592)2.79883928
35Rib fusion (HP:0000902)2.79715057
36Abnormal platelet volume (HP:0011876)2.77257220
37Oral leukoplakia (HP:0002745)2.76896173
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.76707668
39Abnormal protein N-linked glycosylation (HP:0012347)2.76707668
40Abnormal protein glycosylation (HP:0012346)2.76707668
41Abnormal glycosylation (HP:0012345)2.76707668
42Ragged-red muscle fibers (HP:0003200)2.75903578
43Absent forearm bone (HP:0003953)2.72839590
44Aplasia involving forearm bones (HP:0009822)2.72839590
45Patellar aplasia (HP:0006443)2.71973253
46Agammaglobulinemia (HP:0004432)2.71421726
47Trismus (HP:0000211)2.71302649
48Pallor (HP:0000980)2.71233737
49Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.70591332
50Missing ribs (HP:0000921)2.70478786
51Hyperacusis (HP:0010780)2.69181045
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68079915
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68079915
54Impaired platelet aggregation (HP:0003540)2.67706831
55Abnormal platelet function (HP:0011869)2.67706831
56Macrocytic anemia (HP:0001972)2.67677195
57Colitis (HP:0002583)2.67554348
58Recurrent viral infections (HP:0004429)2.64319833
59Asplenia (HP:0001746)2.63395055
60Epistaxis (HP:0000421)2.60329566
61Seborrheic dermatitis (HP:0001051)2.59206795
62Carpal bone hypoplasia (HP:0001498)2.58732591
63Progressive muscle weakness (HP:0003323)2.55182812
64Polycythemia (HP:0001901)2.55142318
65Increased mean platelet volume (HP:0011877)2.53394921
66Ependymoma (HP:0002888)2.52381037
67Centrally nucleated skeletal muscle fibers (HP:0003687)2.52057166
68Abnormality of the nasal mucosa (HP:0000433)2.52015149
69Colon cancer (HP:0003003)2.51477892
70Aplasia/Hypoplasia of the patella (HP:0006498)2.51108765
71Gastrointestinal inflammation (HP:0004386)2.48854793
72Cholelithiasis (HP:0001081)2.47669683
73Achilles tendon contracture (HP:0001771)2.46436688
74Menorrhagia (HP:0000132)2.46169796
75Hepatosplenomegaly (HP:0001433)2.45189846
76Supernumerary spleens (HP:0009799)2.44510350
77Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43928802
78Microretrognathia (HP:0000308)2.41813357
79Rectovaginal fistula (HP:0000143)2.36999229
80Rectal fistula (HP:0100590)2.36999229
81Aplasia/Hypoplasia of the spleen (HP:0010451)2.33938778
82Abnormal large intestine physiology (HP:0012700)2.31797102
83Abnormality of the Achilles tendon (HP:0005109)2.31637729
84Panhypogammaglobulinemia (HP:0003139)2.30995620
85Recurrent abscess formation (HP:0002722)2.30945567
86Increased serum ferritin (HP:0003281)2.29211797
87Broad distal phalanx of finger (HP:0009836)2.28861064
88Insomnia (HP:0100785)2.28593811
89Chromsome breakage (HP:0040012)2.27998837
90Abnormality of macrophages (HP:0004311)2.27616941
91Recurrent bacterial skin infections (HP:0005406)2.27331594
92Orthostatic hypotension (HP:0001278)2.27016726
93Myopathic facies (HP:0002058)2.26188118
94Basal cell carcinoma (HP:0002671)2.25205105
95Abnormality of the ileum (HP:0001549)2.25141050
96Fatigue (HP:0012378)2.24181925
97Meningitis (HP:0001287)2.24035384
98Poikiloderma (HP:0001029)2.23360279
99Bowel incontinence (HP:0002607)2.23097084
100Abnormal number of incisors (HP:0011064)2.22891503
101Abnormality of the fingertips (HP:0001211)2.22707409
102Aplasia/hypoplasia of the humerus (HP:0006507)2.21958366
103Large for gestational age (HP:0001520)2.21813319
104Increased IgE level (HP:0003212)2.21607103
105Aplasia/Hypoplasia of the thymus (HP:0010515)2.20468451
106Medulloblastoma (HP:0002885)2.17928198
107Distal lower limb amyotrophy (HP:0008944)2.17486185
108Duplicated collecting system (HP:0000081)2.17121832
109Neoplasm of the pancreas (HP:0002894)2.16686607
110Progressive external ophthalmoplegia (HP:0000590)2.15363133
111Tongue fasciculations (HP:0001308)2.14180041
112Inflammation of the large intestine (HP:0002037)2.12205370
113Atelectasis (HP:0100750)2.11864679
114Hypoplasia of the radius (HP:0002984)2.10641527
115Hyperinsulinemic hypoglycemia (HP:0000825)2.10182480
116Pancreatic islet-cell hyperplasia (HP:0004510)2.07871987
117Myelodysplasia (HP:0002863)2.06639523
118Vaginal fistula (HP:0004320)2.06422274
119Squamous cell carcinoma (HP:0002860)2.06150471
120Abnormality of the preputium (HP:0100587)2.05549014
121Bone marrow hypocellularity (HP:0005528)2.05521113
122Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05504913
123Dysautonomia (HP:0002459)2.04663964
124Abnormal gallbladder morphology (HP:0012437)2.02663144
125Aplasia/Hypoplasia of the uvula (HP:0010293)2.02573478
126Prominent metopic ridge (HP:0005487)2.02023134
127Abdominal situs inversus (HP:0003363)2.01438800
128Abnormality of abdominal situs (HP:0011620)2.01438800
129Gastrointestinal dysmotility (HP:0002579)2.00897342
130Horseshoe kidney (HP:0000085)2.00511154
131Facial cleft (HP:0002006)2.00397970
132Meckel diverticulum (HP:0002245)1.99146273
133Emphysema (HP:0002097)1.98691863
134Viral hepatitis (HP:0006562)1.98497971
135Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.97416412
136Vertebral hypoplasia (HP:0008417)1.97416412
137IgM deficiency (HP:0002850)1.96621962
138Abnormality of chromosome stability (HP:0003220)1.96206775
139Abnormality of the heme biosynthetic pathway (HP:0010472)1.95265933
140Abnormality of the pancreatic islet cells (HP:0006476)1.94875911
141Abnormality of endocrine pancreas physiology (HP:0012093)1.94875911
142Chronic otitis media (HP:0000389)1.94799738
143Abnormality of the renal collecting system (HP:0004742)1.94621179
144Intestinal fistula (HP:0100819)1.93766066
145Easy fatigability (HP:0003388)1.93687077
146Pancytopenia (HP:0001876)1.93559911
147Slender long bone (HP:0003100)1.93386099
148Abnormal trabecular bone morphology (HP:0100671)1.92828110
149Microvesicular hepatic steatosis (HP:0001414)1.90310321
150Multiple enchondromatosis (HP:0005701)1.89931820
151Acute lymphatic leukemia (HP:0006721)1.89580829
152Paralysis (HP:0003470)1.88106291
153Hypoplasia of the pons (HP:0012110)1.88059953
154Exertional dyspnea (HP:0002875)1.87124784
155Recurrent fungal infections (HP:0002841)1.86950910
156Abnormality of T cell physiology (HP:0011840)1.86694235
157Mediastinal lymphadenopathy (HP:0100721)1.86509486
158Distal lower limb muscle weakness (HP:0009053)1.86476528
159Hypertriglyceridemia (HP:0002155)1.86337693
160Abnormality of the gallbladder (HP:0005264)1.85967636
161Polygenic inheritance (HP:0010982)1.85560852
162Abnormality of the pons (HP:0007361)1.85268932
163Maternal diabetes (HP:0009800)1.84949504
164Lymphoma (HP:0002665)1.84903165
165Muscle fiber atrophy (HP:0100295)1.84827329
166Agnosia (HP:0010524)1.84723949
167Increased connective tissue (HP:0009025)1.82898117
168Hypoparathyroidism (HP:0000829)1.82793496
169Facial hemangioma (HP:0000329)1.81606873
170Short humerus (HP:0005792)1.81561066
171Secondary amenorrhea (HP:0000869)1.81217022
172Abnormal hemoglobin (HP:0011902)1.80766117
173Exercise-induced myalgia (HP:0003738)1.79819833
174Papilloma (HP:0012740)1.78508979
175Verrucae (HP:0200043)1.78508979
176Poikilocytosis (HP:0004447)1.77963309
177Abnormality of cells of the lymphoid lineage (HP:0012140)1.77848464
178Ankyloglossia (HP:0010296)1.77848439
179Ileus (HP:0002595)1.77521880
180Vertebral compression fractures (HP:0002953)1.77248393
181Lymphopenia (HP:0001888)1.77206646
182Increased cerebral lipofuscin (HP:0011813)1.75340574
183Urticaria (HP:0001025)1.75015053
184Diaphragmatic weakness (HP:0009113)1.74863911
185Thrombocytosis (HP:0001894)1.73998860
186Abnormality of iron homeostasis (HP:0011031)1.73908306
187Stridor (HP:0010307)1.73777848
188Osteomyelitis (HP:0002754)1.73361576
189Male infertility (HP:0003251)1.70534643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.40134289
2SMG14.00807748
3TRIB33.65411833
4PRPF4B3.54498622
5PASK3.34916808
6RIPK43.20144579
7WEE13.15720295
8ERN12.87683413
9MAPK152.85123866
10STK162.77768967
11CDC72.64189610
12EIF2AK12.62725336
13EIF2AK32.42355206
14NME22.39640661
15TLK12.18319679
16PIM22.17135531
17EPHA22.14535878
18TESK22.09958716
19DYRK32.08332301
20VRK12.01214503
21CDK71.98643097
22FLT31.94462485
23MAP3K111.91714305
24MAP3K131.85398170
25RPS6KB21.80501264
26SIK11.78679644
27BRSK21.73996128
28PLK11.71174860
29SRPK11.66675001
30TSSK61.65969147
31TTK1.57290100
32NEK21.52186159
33BCKDK1.49411139
34KSR21.46898237
35ATR1.46553335
36SCYL21.45475412
37CHEK21.34264178
38AURKA1.33984368
39ICK1.27833338
40AURKB1.27698521
41BRAF1.27535641
42IRAK31.26452385
43BMX1.25355088
44UHMK11.19661938
45VRK21.18953730
46MAPKAPK31.18017680
47MAP3K141.10441049
48LRRK21.09088984
49PIM11.07526844
50PLK41.06265524
51SIK31.04326495
52HIPK21.03998472
53TBK11.03359498
54YES11.03102185
55FGFR41.02910064
56PRKCI1.02524794
57MAP3K81.00593944
58MAP3K10.98941480
59BRSK10.98515395
60TESK10.94252043
61GRK60.93634692
62CHEK10.93069963
63MAPK110.92987564
64PLK30.92451049
65PAK40.90823739
66TYK20.89420755
67ZAK0.88794074
68DYRK1B0.88086359
69JAK30.86729430
70NEK10.85223209
71KDR0.85077030
72MAP3K60.84931643
73DDR20.84492093
74ACVR1B0.83712979
75MAPK120.82020037
76RAF10.80812965
77MAP3K100.79093974
78RPS6KA40.78496091
79DAPK10.76735566
80MATK0.76394057
81CSNK2A20.75567667
82SIK20.74698819
83SYK0.74687320
84PDPK10.74525328
85TTN0.74444411
86MKNK10.73822179
87DYRK20.72927746
88PKN20.71909615
89RPS6KA50.71267444
90CSNK2A10.70174844
91PTK60.69904922
92MAP2K20.68961803
93FES0.65207848
94* CDK20.64793258
95CDK80.64279734
96ATM0.64145694
97BTK0.63465166
98MARK20.63211050
99CDK40.62453278
100ARAF0.61476821
101PAK10.61361868
102HCK0.61307879
103TAOK10.60806298
104MTOR0.60582773
105EEF2K0.60344450
106CLK10.59583575
107NME10.58893263
108BLK0.58002677
109STK100.57909595
110CDC42BPA0.57862044
111EPHB10.57593995
112ZAP700.55698600
113PDK10.55402605
114TAOK20.54466315
115IRAK40.53954791
116MAP4K10.53384728
117CDK120.53291701
118TNK20.52713118
119DAPK30.51885626
120TGFBR10.51867409
121MKNK20.51059536
122MAP3K30.50578428
123PRKD20.50575223
124AKT30.49662665
125CSK0.48259199
126STK40.46843918
127MAP2K30.46131724
128IRAK20.45669384
129IKBKB0.44013810
130RPS6KL10.42448597
131RPS6KC10.42448597
132ALK0.41489074
133MARK30.40574793
134BRD40.39495624
135CDK90.39315753
136ITK0.38940221
137INSRR0.37756464
138* CDK10.37745958
139LIMK10.36175192
140CDK60.35908684
141RPS6KA60.35665817
142MAPKAPK20.35590517
143LYN0.34871874
144ILK0.33226304
145PRKDC0.30331809

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74826567
2Mismatch repair_Homo sapiens_hsa034304.44002274
3Ribosome_Homo sapiens_hsa030103.84745765
4RNA polymerase_Homo sapiens_hsa030203.32529659
5Base excision repair_Homo sapiens_hsa034103.18750769
6Proteasome_Homo sapiens_hsa030503.16963679
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14254780
8Spliceosome_Homo sapiens_hsa030403.11016486
9Homologous recombination_Homo sapiens_hsa034402.84506943
10Nucleotide excision repair_Homo sapiens_hsa034202.79200047
11Protein export_Homo sapiens_hsa030602.75266220
12RNA transport_Homo sapiens_hsa030132.57158833
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.55265582
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.45707519
15One carbon pool by folate_Homo sapiens_hsa006702.40358732
16Pyrimidine metabolism_Homo sapiens_hsa002402.36439206
17B cell receptor signaling pathway_Homo sapiens_hsa046622.34091248
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16631687
19Cell cycle_Homo sapiens_hsa041102.08537821
20Fanconi anemia pathway_Homo sapiens_hsa034601.96801212
21Non-small cell lung cancer_Homo sapiens_hsa052231.89886659
22RNA degradation_Homo sapiens_hsa030181.72418654
23Non-homologous end-joining_Homo sapiens_hsa034501.71034181
24Pancreatic cancer_Homo sapiens_hsa052121.64818051
25Basal transcription factors_Homo sapiens_hsa030221.60278048
26Folate biosynthesis_Homo sapiens_hsa007901.49463989
27mRNA surveillance pathway_Homo sapiens_hsa030151.48191561
28p53 signaling pathway_Homo sapiens_hsa041151.45729737
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.45369234
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39282197
31VEGF signaling pathway_Homo sapiens_hsa043701.37434118
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35149024
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29977029
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29468698
35Purine metabolism_Homo sapiens_hsa002301.25178801
36Leishmaniasis_Homo sapiens_hsa051401.25150509
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25005134
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.24741977
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16408777
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12225704
41Carbon metabolism_Homo sapiens_hsa012001.11657304
42Osteoclast differentiation_Homo sapiens_hsa043801.09833075
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.09154663
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05218946
45N-Glycan biosynthesis_Homo sapiens_hsa005101.01783728
46Epstein-Barr virus infection_Homo sapiens_hsa051690.99629844
47Influenza A_Homo sapiens_hsa051640.97838516
48Sulfur relay system_Homo sapiens_hsa041220.95140386
49T cell receptor signaling pathway_Homo sapiens_hsa046600.94008586
50Systemic lupus erythematosus_Homo sapiens_hsa053220.93723629
51Viral myocarditis_Homo sapiens_hsa054160.92102084
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91971499
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91683618
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91485961
55Platelet activation_Homo sapiens_hsa046110.90222286
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88034387
57Prion diseases_Homo sapiens_hsa050200.87338354
58Endometrial cancer_Homo sapiens_hsa052130.85199626
59Allograft rejection_Homo sapiens_hsa053300.85184244
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.82248512
61Selenocompound metabolism_Homo sapiens_hsa004500.79226299
62Viral carcinogenesis_Homo sapiens_hsa052030.79057523
63Glioma_Homo sapiens_hsa052140.77581561
64Hepatitis C_Homo sapiens_hsa051600.77259663
65Huntingtons disease_Homo sapiens_hsa050160.76470686
66Toxoplasmosis_Homo sapiens_hsa051450.76323845
67Parkinsons disease_Homo sapiens_hsa050120.74748422
68Autoimmune thyroid disease_Homo sapiens_hsa053200.73080499
69Hematopoietic cell lineage_Homo sapiens_hsa046400.70952195
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.69359835
71Graft-versus-host disease_Homo sapiens_hsa053320.69137808
72Insulin signaling pathway_Homo sapiens_hsa049100.68737400
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68228673
74Oxidative phosphorylation_Homo sapiens_hsa001900.66840031
75Antigen processing and presentation_Homo sapiens_hsa046120.65861155
76Renal cell carcinoma_Homo sapiens_hsa052110.64294696
77Tuberculosis_Homo sapiens_hsa051520.64232812
78Alcoholism_Homo sapiens_hsa050340.64212750
79Legionellosis_Homo sapiens_hsa051340.62918448
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61731200
81Bladder cancer_Homo sapiens_hsa052190.57284483
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.56457624
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.56210095
84Herpes simplex infection_Homo sapiens_hsa051680.55942398
85Oocyte meiosis_Homo sapiens_hsa041140.55678396
86HIF-1 signaling pathway_Homo sapiens_hsa040660.55609118
87Fructose and mannose metabolism_Homo sapiens_hsa000510.54709551
88Thyroid cancer_Homo sapiens_hsa052160.54119719
89Chemokine signaling pathway_Homo sapiens_hsa040620.53107217
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52222858
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52030120
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.51671178
93Other glycan degradation_Homo sapiens_hsa005110.50653949
94Endocytosis_Homo sapiens_hsa041440.50059134
95HTLV-I infection_Homo sapiens_hsa051660.49193032
96Primary immunodeficiency_Homo sapiens_hsa053400.49037844
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48834161
98Choline metabolism in cancer_Homo sapiens_hsa052310.48590293
99Notch signaling pathway_Homo sapiens_hsa043300.46889978
100Galactose metabolism_Homo sapiens_hsa000520.46836559
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45783291
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45271526
103Shigellosis_Homo sapiens_hsa051310.45178162
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44778188
105TNF signaling pathway_Homo sapiens_hsa046680.44417113
106ErbB signaling pathway_Homo sapiens_hsa040120.44260474
107Hedgehog signaling pathway_Homo sapiens_hsa043400.43208901
108Glutathione metabolism_Homo sapiens_hsa004800.41800531
109* Biosynthesis of amino acids_Homo sapiens_hsa012300.40547580
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40292152
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.39812949
112Pentose phosphate pathway_Homo sapiens_hsa000300.38646696
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38282836
114Hippo signaling pathway_Homo sapiens_hsa043900.36787590
115Basal cell carcinoma_Homo sapiens_hsa052170.36327572
116Vibrio cholerae infection_Homo sapiens_hsa051100.34616884
117Apoptosis_Homo sapiens_hsa042100.33724685
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.32674028
119TGF-beta signaling pathway_Homo sapiens_hsa043500.32321645
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32307247
121Arachidonic acid metabolism_Homo sapiens_hsa005900.29940614
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28983579
123* Metabolic pathways_Homo sapiens_hsa011000.27476274
124Linoleic acid metabolism_Homo sapiens_hsa005910.26811153
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25974165
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.25824168
127Alzheimers disease_Homo sapiens_hsa050100.25394374
128Type I diabetes mellitus_Homo sapiens_hsa049400.24210946
129Acute myeloid leukemia_Homo sapiens_hsa052210.23836238
130MicroRNAs in cancer_Homo sapiens_hsa052060.23392422
131Colorectal cancer_Homo sapiens_hsa052100.22345461
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21197626
133Small cell lung cancer_Homo sapiens_hsa052220.20062321
134Chronic myeloid leukemia_Homo sapiens_hsa052200.17935090
135Wnt signaling pathway_Homo sapiens_hsa043100.16914278
136Hepatitis B_Homo sapiens_hsa051610.15178216
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14926221
138Measles_Homo sapiens_hsa051620.14692706
139Lysosome_Homo sapiens_hsa041420.14641417
140Regulation of autophagy_Homo sapiens_hsa041400.14526058
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13265052
142Pathways in cancer_Homo sapiens_hsa052000.12427067
143mTOR signaling pathway_Homo sapiens_hsa041500.12239811
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.11900900
145* Arginine and proline metabolism_Homo sapiens_hsa003300.11561808
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10880817
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09868157
148Prostate cancer_Homo sapiens_hsa052150.09046618
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08037172

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