PYCRL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.67859035
2transcription from mitochondrial promoter (GO:0006390)7.32160322
3replication fork processing (GO:0031297)6.82286873
4* proline biosynthetic process (GO:0006561)6.48561176
5maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.83832932
6embryonic process involved in female pregnancy (GO:0060136)5.57177661
7viral mRNA export from host cell nucleus (GO:0046784)5.41043563
8oxidative demethylation (GO:0070989)5.31583635
9telomere maintenance via semi-conservative replication (GO:0032201)5.28253041
10positive regulation of protein homooligomerization (GO:0032464)5.23993789
11somatic diversification of immune receptors via somatic mutation (GO:0002566)5.16278434
12somatic hypermutation of immunoglobulin genes (GO:0016446)5.16278434
13mitochondrial DNA metabolic process (GO:0032042)5.13140676
14* proline metabolic process (GO:0006560)5.10399843
15formation of translation preinitiation complex (GO:0001731)4.91047591
16DNA strand renaturation (GO:0000733)4.78946654
17DNA strand elongation involved in DNA replication (GO:0006271)4.64803688
18regulation of protein homooligomerization (GO:0032462)4.59798293
19nucleotide-excision repair, DNA gap filling (GO:0006297)4.53982715
20regulation of integrin activation (GO:0033623)4.43666333
21establishment of protein localization to mitochondrial membrane (GO:0090151)4.42879227
22poly(A)+ mRNA export from nucleus (GO:0016973)4.40186265
23base-excision repair (GO:0006284)4.39568423
24DNA strand elongation (GO:0022616)4.39078982
25establishment of apical/basal cell polarity (GO:0035089)4.37797457
26telomere maintenance via recombination (GO:0000722)4.35267976
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.29830910
28base-excision repair, AP site formation (GO:0006285)4.23721991
29negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.18556065
30mitotic G1 DNA damage checkpoint (GO:0031571)4.14044293
31regulation of mitochondrial translation (GO:0070129)4.10949781
32pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.05855974
33negative regulation of cell cycle arrest (GO:0071157)4.04378544
34mRNA cleavage (GO:0006379)4.03204099
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.97304074
36GTP biosynthetic process (GO:0006183)3.97285240
37UTP biosynthetic process (GO:0006228)3.96326378
38DNA integration (GO:0015074)3.95798569
39maturation of 5.8S rRNA (GO:0000460)3.95703317
40mitochondrial RNA metabolic process (GO:0000959)3.95101005
41regulation of response to tumor cell (GO:0002834)3.89531503
42positive regulation of response to tumor cell (GO:0002836)3.89531503
43positive regulation of immune response to tumor cell (GO:0002839)3.89531503
44regulation of immune response to tumor cell (GO:0002837)3.89531503
45guanosine-containing compound biosynthetic process (GO:1901070)3.85561738
46cullin deneddylation (GO:0010388)3.85557823
47GDP-mannose metabolic process (GO:0019673)3.84691691
48termination of RNA polymerase II transcription (GO:0006369)3.83955923
49regulation of translational fidelity (GO:0006450)3.78009703
50protein deneddylation (GO:0000338)3.76460623
51mitotic recombination (GO:0006312)3.75587200
52establishment or maintenance of monopolar cell polarity (GO:0061339)3.73499194
53establishment of monopolar cell polarity (GO:0061162)3.73499194
54telomere maintenance via telomere lengthening (GO:0010833)3.73186301
55kinetochore assembly (GO:0051382)3.72201185
56pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.66995854
57regulation of double-strand break repair via homologous recombination (GO:0010569)3.66462604
58negative regulation of mRNA processing (GO:0050686)3.64414049
59pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.60497829
60termination of RNA polymerase III transcription (GO:0006386)3.60160200
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.60160200
62non-recombinational repair (GO:0000726)3.59861676
63double-strand break repair via nonhomologous end joining (GO:0006303)3.59861676
64mitotic G1/S transition checkpoint (GO:0044819)3.59478336
65iron-sulfur cluster assembly (GO:0016226)3.59118380
66metallo-sulfur cluster assembly (GO:0031163)3.59118380
67CTP metabolic process (GO:0046036)3.59067112
68CTP biosynthetic process (GO:0006241)3.59067112
69G1 DNA damage checkpoint (GO:0044783)3.58915952
70tRNA modification (GO:0006400)3.58018135
71mitochondrial DNA replication (GO:0006264)3.56032625
72peptidyl-arginine omega-N-methylation (GO:0035247)3.52717491
73negative regulation of RNA splicing (GO:0033119)3.52656464
74DNA double-strand break processing (GO:0000729)3.52520872
75pyrimidine nucleotide catabolic process (GO:0006244)3.49797308
76ribosomal small subunit biogenesis (GO:0042274)3.49517165
77DNA ligation (GO:0006266)3.48902527
78negative regulation of JAK-STAT cascade (GO:0046426)3.46854592
79ncRNA 3-end processing (GO:0043628)3.46817294
80UTP metabolic process (GO:0046051)3.42816752
81spliceosomal tri-snRNP complex assembly (GO:0000244)3.41947360
82DNA topological change (GO:0006265)3.36476293
83chaperone-mediated protein transport (GO:0072321)3.33959018
84pseudouridine synthesis (GO:0001522)3.33543840
85folic acid metabolic process (GO:0046655)3.30254291
86tRNA methylation (GO:0030488)3.28502470
87meiotic chromosome segregation (GO:0045132)3.26162885
88positive regulation of DNA repair (GO:0045739)3.25683228
89cellular response to zinc ion (GO:0071294)3.23644615
90pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.22955397
91kinetochore organization (GO:0051383)3.22455962
92viral transcription (GO:0019083)3.21010700
93protein insertion into membrane (GO:0051205)3.20259453
94rRNA modification (GO:0000154)3.19524427
95negative regulation of fatty acid biosynthetic process (GO:0045717)3.18235679
96ribonucleoprotein complex biogenesis (GO:0022613)3.16510929
97positive regulation of developmental pigmentation (GO:0048087)3.14152267
98maturation of SSU-rRNA (GO:0030490)3.13061784
99negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.12890997
100translational initiation (GO:0006413)3.11769285
101rRNA transcription (GO:0009303)3.10933357
102negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.07957654
103resolution of meiotic recombination intermediates (GO:0000712)3.07379637
104regulation of double-strand break repair (GO:2000779)3.05935986
105DNA demethylation (GO:0080111)3.05799792
106tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05675948
107RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05675948
108translational termination (GO:0006415)3.05028048
109regulation of sister chromatid cohesion (GO:0007063)3.04808382
110spliceosomal snRNP assembly (GO:0000387)3.04611714
111cellular response to ATP (GO:0071318)3.03780636
112protein maturation by protein folding (GO:0022417)3.03204618
113dosage compensation (GO:0007549)3.03010962
114peptidyl-histidine modification (GO:0018202)3.02993316
115rRNA processing (GO:0006364)2.99891996
116mitotic nuclear envelope reassembly (GO:0007084)2.99564264
117nuclear envelope reassembly (GO:0031468)2.99564264
118proteasome assembly (GO:0043248)2.98319997
119positive regulation by host of viral transcription (GO:0043923)2.97316270
120histone arginine methylation (GO:0034969)2.97258335
121L-serine metabolic process (GO:0006563)2.96687405
122ribosome biogenesis (GO:0042254)2.95443240
123deoxyribose phosphate biosynthetic process (GO:0046385)2.94873774
1242-deoxyribonucleotide biosynthetic process (GO:0009265)2.94873774
125DNA replication checkpoint (GO:0000076)2.94862606
126pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.94454473
127regulation of DNA damage checkpoint (GO:2000001)2.94088535
128positive regulation of protein oligomerization (GO:0032461)2.93879248
129embryonic placenta development (GO:0001892)2.92829841
130translational elongation (GO:0006414)2.92706827
131transcription-coupled nucleotide-excision repair (GO:0006283)2.92594609
132nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91564125
133protein targeting to mitochondrion (GO:0006626)2.90896177
134oxidative phosphorylation (GO:0006119)2.90352987
135establishment of protein localization to mitochondrion (GO:0072655)2.90329125
136tRNA processing (GO:0008033)2.89228843
137dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.88878497
138respiratory tube development (GO:0030323)2.88478563
139ribosomal small subunit assembly (GO:0000028)2.88032307
140positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.87685406
141positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.87685406
142positive regulation of mitotic sister chromatid separation (GO:1901970)2.87685406
143mRNA export from nucleus (GO:0006406)2.87677527
144peptidyl-arginine methylation (GO:0018216)2.87300427
145peptidyl-arginine N-methylation (GO:0035246)2.87300427
146negative regulation of mRNA metabolic process (GO:1903312)2.86595028
147negative regulation of cell aging (GO:0090344)2.86578975
148mannosylation (GO:0097502)2.86543081
149DNA replication initiation (GO:0006270)2.86254842
150cellular component biogenesis (GO:0044085)2.86100427
151rRNA metabolic process (GO:0016072)2.86073576
152protein import into peroxisome matrix (GO:0016558)2.84445076
153deoxyribonucleotide catabolic process (GO:0009264)2.83671105
154negative regulation of protein oligomerization (GO:0032460)2.83570346
155sulfur amino acid catabolic process (GO:0000098)2.83202400
156establishment of integrated proviral latency (GO:0075713)2.80927819
157ubiquinone biosynthetic process (GO:0006744)2.79217910
158ribosomal large subunit biogenesis (GO:0042273)2.78977496
159positive regulation of muscle cell apoptotic process (GO:0010661)2.76484904
160nucleobase-containing small molecule interconversion (GO:0015949)2.75795304
161purine deoxyribonucleotide catabolic process (GO:0009155)2.73516677
162negative regulation of telomere maintenance (GO:0032205)2.71993404
163UV protection (GO:0009650)2.69850513
164negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.69465141
165mitochondrial calcium ion transport (GO:0006851)2.67890516
166establishment of viral latency (GO:0019043)2.67295462
167DNA unwinding involved in DNA replication (GO:0006268)2.67262849
168tRNA metabolic process (GO:0006399)2.66342124
169ncRNA processing (GO:0034470)2.65790635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.64802817
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.08332160
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.60301389
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.47430715
5MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02675615
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89908600
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85140633
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62097021
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.43957979
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32051596
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.31803767
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.29440754
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27649567
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.20191110
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.15589487
16* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15261727
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12028701
18* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09681397
19VDR_21846776_ChIP-Seq_THP-1_Human2.05241853
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03633137
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.02836582
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02700364
23DCP1A_22483619_ChIP-Seq_HELA_Human2.02108073
24* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97545469
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96385910
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.94671466
27GABP_19822575_ChIP-Seq_HepG2_Human1.92942566
28* XRN2_22483619_ChIP-Seq_HELA_Human1.88972186
29* P68_20966046_ChIP-Seq_HELA_Human1.88869775
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85485939
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82135839
32KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81223209
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71207517
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71207517
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71207517
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70527744
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70456315
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68631638
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68260199
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68258672
41TTF2_22483619_ChIP-Seq_HELA_Human1.67312373
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66454535
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65998162
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65045024
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63419231
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.62524217
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61936970
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.61367787
49SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.59527619
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58552466
51VDR_23849224_ChIP-Seq_CD4+_Human1.57848171
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56338941
53RACK7_27058665_Chip-Seq_MCF-7_Human1.54321137
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52348056
55CIITA_25753668_ChIP-Seq_RAJI_Human1.51739592
56MYC_22102868_ChIP-Seq_BL_Human1.49190494
57PU.1_20513432_ChIP-Seq_Bcells_Mouse1.49036643
58NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48771870
59* BCL6_27268052_Chip-Seq_Bcells_Human1.48741330
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.46964363
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46836652
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46579445
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46419409
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.45220362
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44363443
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.43061224
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.43018126
68* E2F1_20622854_ChIP-Seq_HELA_Human1.40235904
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40069055
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38687884
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38434010
72KDM5A_27292631_Chip-Seq_BREAST_Human1.38373009
73* BCOR_27268052_Chip-Seq_Bcells_Human1.36764103
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36422614
75* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.36066299
76CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35607116
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.34698937
78FOXP3_21729870_ChIP-Seq_TREG_Human1.33328617
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33213582
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32750561
81TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30444698
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29314086
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29003234
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28999680
85* RARB_24833708_ChIP-Seq_LIVER_Mouse1.28956450
86* LXR_22292898_ChIP-Seq_THP-1_Human1.27833443
87CTCF_26484167_Chip-Seq_Bcells_Mouse1.27703641
88* PHF8_20622854_ChIP-Seq_HELA_Human1.26897498
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25900717
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24139300
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.23535882
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22944068
93RARA_24833708_ChIP-Seq_LIVER_Mouse1.22464712
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21373083
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.21244765
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.19609973
97ZNF263_19887448_ChIP-Seq_K562_Human1.19378082
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.18989547
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18253371
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16053893
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.15656511
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15638512
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15180583
104SMC4_20622854_ChIP-Seq_HELA_Human1.14952655
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14825890
106OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14195191
107EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14020628
108POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14011134
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13220049
110CTCF_21964334_Chip-Seq_Bcells_Human1.12612259
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11804950
112RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11168458
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10933833
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10773464
115SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10413109
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09754022
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09557982
118CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06951252
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06890049
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04955121
121MAF_26560356_Chip-Seq_TH2_Human1.04127956
122CTCF_20526341_ChIP-Seq_ESCs_Human1.04007893
123TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03161600
124TP53_22127205_ChIP-Seq_IMR90_Human1.02975703
125ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02625489
126RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01220743
127ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00067373
128TFEB_21752829_ChIP-Seq_HELA_Human0.98967243
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98867582
130ETS1_21867929_ChIP-Seq_TH2_Mouse0.98495193
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96415868
132ERG_21242973_ChIP-ChIP_JURKAT_Human0.95369301
133YY1_22570637_ChIP-Seq_MALME-3M_Human0.94865193
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94590059
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93968840
136NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93810293
137CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93772725
138SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93660060
139* FOXP1_21924763_ChIP-Seq_HESCs_Human0.93276734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.30011691
2MP0010030_abnormal_orbit_morphology3.77037963
3MP0005171_absent_coat_pigmentation3.60548048
4MP0001346_abnormal_lacrimal_gland3.40879355
5MP0010094_abnormal_chromosome_stability3.40709900
6MP0009278_abnormal_bone_marrow3.24342042
7MP0004957_abnormal_blastocyst_morpholog3.16109271
8MP0003693_abnormal_embryo_hatching2.97752648
9MP0002160_abnormal_reproductive_system2.79489826
10MP0004233_abnormal_muscle_weight2.62921605
11MP0008058_abnormal_DNA_repair2.56497861
12MP0003111_abnormal_nucleus_morphology2.56451027
13MP0003315_abnormal_perineum_morphology2.47545494
14MP0003890_abnormal_embryonic-extraembry2.42088314
15MP0003077_abnormal_cell_cycle2.31456471
16MP0002009_preneoplasia2.27324167
17MP0008932_abnormal_embryonic_tissue2.23034365
18MP0008875_abnormal_xenobiotic_pharmacok2.20346178
19MP0003786_premature_aging2.12172680
20MP0004133_heterotaxia1.99590968
21MP0005174_abnormal_tail_pigmentation1.98299068
22MP0003123_paternal_imprinting1.93241591
23MP0000490_abnormal_crypts_of1.92758715
24MP0003119_abnormal_digestive_system1.92734057
25MP0000537_abnormal_urethra_morphology1.90959640
26MP0005397_hematopoietic_system_phenotyp1.88900326
27MP0001545_abnormal_hematopoietic_system1.88900326
28MP0001873_stomach_inflammation1.88690172
29MP0008995_early_reproductive_senescence1.87786879
30MP0005083_abnormal_biliary_tract1.77726900
31MP0002249_abnormal_larynx_morphology1.75300945
32MP0002736_abnormal_nociception_after1.72925332
33MP0005257_abnormal_intraocular_pressure1.72887354
34MP0008877_abnormal_DNA_methylation1.70309400
35MP0001697_abnormal_embryo_size1.65478654
36MP0005501_abnormal_skin_physiology1.64661354
37MP0006072_abnormal_retinal_apoptosis1.64001722
38MP0001661_extended_life_span1.62147433
39MP0000678_abnormal_parathyroid_gland1.59928294
40MP0001293_anophthalmia1.58223065
41MP0005075_abnormal_melanosome_morpholog1.57956173
42MP0000681_abnormal_thyroid_gland1.57650770
43MP0010352_gastrointestinal_tract_polyps1.56450753
44MP0003567_abnormal_fetal_cardiomyocyte1.56373847
45MP0002653_abnormal_ependyma_morphology1.56306094
46MP0001919_abnormal_reproductive_system1.56107802
47MP0002282_abnormal_trachea_morphology1.55190264
48MP0005389_reproductive_system_phenotype1.55132783
49MP0003718_maternal_effect1.54881291
50MP0005085_abnormal_gallbladder_physiolo1.52378226
51MP0002163_abnormal_gland_morphology1.52222863
52MP0002086_abnormal_extraembryonic_tissu1.49107802
53MP0003283_abnormal_digestive_organ1.48725552
54MP0008789_abnormal_olfactory_epithelium1.48508813
55MP0001730_embryonic_growth_arrest1.46320666
56MP0005365_abnormal_bile_salt1.43523266
57MP0000358_abnormal_cell_content/1.43024137
58MP0002085_abnormal_embryonic_tissue1.41480049
59MP0002084_abnormal_developmental_patter1.40874281
60MP0001968_abnormal_touch/_nociception1.40310469
61MP0000350_abnormal_cell_proliferation1.38580756
62MP0002234_abnormal_pharynx_morphology1.37862241
63MP0003806_abnormal_nucleotide_metabolis1.36751528
64MP0001188_hyperpigmentation1.36269740
65MP0001672_abnormal_embryogenesis/_devel1.35720160
66MP0005380_embryogenesis_phenotype1.35720160
67MP0000015_abnormal_ear_pigmentation1.32486235
68MP0004197_abnormal_fetal_growth/weight/1.29909742
69MP0006035_abnormal_mitochondrial_morpho1.27511342
70MP0008007_abnormal_cellular_replicative1.24843794
71MP0002210_abnormal_sex_determination1.23485241
72MP0002019_abnormal_tumor_incidence1.22422875
73MP0004858_abnormal_nervous_system1.22157342
74MP0000371_diluted_coat_color1.21961431
75MP0008872_abnormal_physiological_respon1.21733628
76MP0002111_abnormal_tail_morphology1.20524879
77MP0002080_prenatal_lethality1.17980554
78MP0005646_abnormal_pituitary_gland1.17281039
79MP0002877_abnormal_melanocyte_morpholog1.16453939
80MP0003136_yellow_coat_color1.15875342
81MP0005451_abnormal_body_composition1.15481568
82MP0000470_abnormal_stomach_morphology1.15408234
83MP0005266_abnormal_metabolism1.14798255
84MP0000750_abnormal_muscle_regeneration1.11831072
85MP0002876_abnormal_thyroid_physiology1.11390826
86MP0005394_taste/olfaction_phenotype1.11351676
87MP0005499_abnormal_olfactory_system1.11351676
88MP0002269_muscular_atrophy1.10472132
89MP0002396_abnormal_hematopoietic_system1.09024934
90MP0003984_embryonic_growth_retardation1.07578747
91MP0004147_increased_porphyrin_level1.07350857
92MP0000639_abnormal_adrenal_gland1.07126374
93MP0003453_abnormal_keratinocyte_physiol1.06049271
94MP0009053_abnormal_anal_canal1.04130016
95MP0000462_abnormal_digestive_system1.03080571
96MP0002088_abnormal_embryonic_growth/wei1.03019879
97MP0000313_abnormal_cell_death1.01469248
98MP0005076_abnormal_cell_differentiation0.99671708
99MP0004264_abnormal_extraembryonic_tissu0.99109936
100MP0000579_abnormal_nail_morphology0.98392761
101MP0000538_abnormal_urinary_bladder0.97959435
102MP0002932_abnormal_joint_morphology0.97855222
103MP0009333_abnormal_splenocyte_physiolog0.97334840
104MP0000566_synostosis0.97226143
105MP0000003_abnormal_adipose_tissue0.96838293
106MP0003172_abnormal_lysosome_physiology0.94258390
107MP0002075_abnormal_coat/hair_pigmentati0.93494645
108MP0005410_abnormal_fertilization0.92852232
109MP0006036_abnormal_mitochondrial_physio0.92466524
110MP0001764_abnormal_homeostasis0.92137478
111MP0001929_abnormal_gametogenesis0.90565385
112MP0001186_pigmentation_phenotype0.87472240
113MP0003698_abnormal_male_reproductive0.85643863
114MP0005423_abnormal_somatic_nervous0.85049935
115MP0010771_integument_phenotype0.84816173
116MP0001340_abnormal_eyelid_morphology0.83481635
117MP0002132_abnormal_respiratory_system0.82696185
118MP0003705_abnormal_hypodermis_morpholog0.81474814
119MP0002114_abnormal_axial_skeleton0.81327021
120MP0001986_abnormal_taste_sensitivity0.80875754
121MP0002098_abnormal_vibrissa_morphology0.79707969
122MP0000467_abnormal_esophagus_morphology0.78638821
123MP0002177_abnormal_outer_ear0.78429950
124MP0001881_abnormal_mammary_gland0.77947733
125MP0000049_abnormal_middle_ear0.77164107
126MP0004145_abnormal_muscle_electrophysio0.77157484
127MP0000653_abnormal_sex_gland0.76965570
128MP0002089_abnormal_postnatal_growth/wei0.76448055
129MP0004019_abnormal_vitamin_homeostasis0.76186851
130MP0001145_abnormal_male_reproductive0.75949970
131MP0000685_abnormal_immune_system0.75085405
132MP0003186_abnormal_redox_activity0.74976676
133MP0001664_abnormal_digestion0.73046763
134MP0005058_abnormal_lysosome_morphology0.72842466
135MP0003656_abnormal_erythrocyte_physiolo0.70421834
136MP0000013_abnormal_adipose_tissue0.70267882
137MP0000477_abnormal_intestine_morphology0.70215674
138MP0005645_abnormal_hypothalamus_physiol0.70114945
139MP0003943_abnormal_hepatobiliary_system0.67931303
140MP0002938_white_spotting0.67879127
141MP0003755_abnormal_palate_morphology0.67686284
142MP0001324_abnormal_eye_pigmentation0.67506171
143MP0005330_cardiomyopathy0.67290767
144MP0005376_homeostasis/metabolism_phenot0.67072329
145MP0000762_abnormal_tongue_morphology0.67059734
146MP0000689_abnormal_spleen_morphology0.66246010
147MP0005332_abnormal_amino_acid0.65476916
148MP0002405_respiratory_system_inflammati0.65036116
149MP0006292_abnormal_olfactory_placode0.64982071
150MP0001529_abnormal_vocalization0.64626178
151MP0001119_abnormal_female_reproductive0.64386550
152MP0004782_abnormal_surfactant_physiolog0.63876672
153MP0009115_abnormal_fat_cell0.63581078
154MP0001727_abnormal_embryo_implantation0.62808003
155MP0005379_endocrine/exocrine_gland_phen0.62734679
156MP0002116_abnormal_craniofacial_bone0.62330209
157MP0003935_abnormal_craniofacial_develop0.61865238
158MP0005220_abnormal_exocrine_pancreas0.61544406
159MP0002970_abnormal_white_adipose0.60713364
160MP0002060_abnormal_skin_morphology0.60402000

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.07460229
2Testicular atrophy (HP:0000029)4.81591492
3Concave nail (HP:0001598)4.45893850
4Pustule (HP:0200039)4.41006741
5Poikiloderma (HP:0001029)4.38192093
6Facial hemangioma (HP:0000329)4.37395133
7Rectovaginal fistula (HP:0000143)4.37028606
8Rectal fistula (HP:0100590)4.37028606
9Increased IgM level (HP:0003496)4.27326815
10Annular pancreas (HP:0001734)4.24118064
11Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.98543398
12Vaginal fistula (HP:0004320)3.92586262
13Tongue fasciculations (HP:0001308)3.91048696
14Abnormal hemoglobin (HP:0011902)3.82653190
15Intestinal fistula (HP:0100819)3.75092393
16Hypochromic microcytic anemia (HP:0004840)3.57537112
17Alopecia of scalp (HP:0002293)3.55170712
18Increased intramyocellular lipid droplets (HP:0012240)3.52269221
19Muscle fibrillation (HP:0010546)3.45928197
20Absent thumb (HP:0009777)3.42488317
21Orthostatic hypotension (HP:0001278)3.35943385
22Increased muscle lipid content (HP:0009058)3.34081082
23Patellar aplasia (HP:0006443)3.29295164
24Turricephaly (HP:0000262)3.24817472
25Selective tooth agenesis (HP:0001592)3.24361599
26Absent radius (HP:0003974)3.20742630
27Aplasia/hypoplasia of the humerus (HP:0006507)3.15849108
28Vertebral hypoplasia (HP:0008417)3.09108670
29Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.09108670
30Ulnar bowing (HP:0003031)3.08833448
31Lipid accumulation in hepatocytes (HP:0006561)3.08055497
32Increased hepatocellular lipid droplets (HP:0006565)3.07830976
33Exertional dyspnea (HP:0002875)3.05787046
34Short humerus (HP:0005792)3.04509702
35Coronal craniosynostosis (HP:0004440)3.03856906
36Intestinal atresia (HP:0011100)3.03109488
37Aplasia/Hypoplasia of the patella (HP:0006498)3.02830576
38Absent forearm bone (HP:0003953)2.99790225
39Aplasia involving forearm bones (HP:0009822)2.99790225
40Microretrognathia (HP:0000308)2.98285979
41Squamous cell carcinoma (HP:0002860)2.98193015
42Attenuation of retinal blood vessels (HP:0007843)2.97917232
43Premature graying of hair (HP:0002216)2.96912404
44Hepatocellular necrosis (HP:0001404)2.95250280
45Male infertility (HP:0003251)2.93015764
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.92573074
47Abnormality of the aortic arch (HP:0012303)2.89766190
48Abnormality of male internal genitalia (HP:0000022)2.88204110
49Mitochondrial inheritance (HP:0001427)2.84788093
50Pancreatic islet-cell hyperplasia (HP:0004510)2.83073061
51Abnormality of cells of the erythroid lineage (HP:0012130)2.82113043
52Broad alveolar ridges (HP:0000187)2.81253960
53Abnormal number of erythroid precursors (HP:0012131)2.75967434
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.73158294
55Renal Fanconi syndrome (HP:0001994)2.69375036
56Basal cell carcinoma (HP:0002671)2.67912514
57Increased CSF lactate (HP:0002490)2.65319711
58Hepatic necrosis (HP:0002605)2.64729653
59Increased serum lactate (HP:0002151)2.62834347
60Dysautonomia (HP:0002459)2.62336325
61Congenital hip dislocation (HP:0001374)2.59190116
62Short chin (HP:0000331)2.58806232
63Muscle fiber atrophy (HP:0100295)2.58115786
64Hypochromic anemia (HP:0001931)2.56821856
65Hypokinesia (HP:0002375)2.55324641
66Albinism (HP:0001022)2.53968020
67Abnormal number of incisors (HP:0011064)2.47738482
68Ragged-red muscle fibers (HP:0003200)2.47236797
69Diaphragmatic weakness (HP:0009113)2.43200139
70Abnormal mitochondria in muscle tissue (HP:0008316)2.42630461
71Large for gestational age (HP:0001520)2.41505476
72Abnormality of placental membranes (HP:0011409)2.40781053
73Amniotic constriction ring (HP:0009775)2.40781053
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40348847
75Type 2 muscle fiber atrophy (HP:0003554)2.39626610
76Premature skin wrinkling (HP:0100678)2.39452044
77Alacrima (HP:0000522)2.38999297
78Mucopolysacchariduria (HP:0008155)2.38872007
79Urinary glycosaminoglycan excretion (HP:0003541)2.38872007
80Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38130335
81Abnormal protein N-linked glycosylation (HP:0012347)2.38130335
82Abnormal protein glycosylation (HP:0012346)2.38130335
83Abnormal glycosylation (HP:0012345)2.38130335
84Redundant skin (HP:0001582)2.37977158
85Joint stiffness (HP:0001387)2.36735801
86Bifid uvula (HP:0000193)2.35799699
87Anteriorly placed anus (HP:0001545)2.35578912
88Capillary hemangiomas (HP:0005306)2.35166178
89Hypoplasia of the radius (HP:0002984)2.32829313
90Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31916986
91IgA deficiency (HP:0002720)2.31441862
92Rough bone trabeculation (HP:0100670)2.31424668
93Reticulocytopenia (HP:0001896)2.30887513
94Broad distal phalanx of finger (HP:0009836)2.30685385
95Aplasia of the musculature (HP:0100854)2.30195186
96Breast hypoplasia (HP:0003187)2.28780367
97Popliteal pterygium (HP:0009756)2.26594312
98Choanal stenosis (HP:0000452)2.26285874
99Abnormal trabecular bone morphology (HP:0100671)2.25008956
100Type I transferrin isoform profile (HP:0003642)2.23798207
101Brushfield spots (HP:0001088)2.23012771
102Acute lymphatic leukemia (HP:0006721)2.22298408
103Progressive microcephaly (HP:0000253)2.21836536
104Myotonia (HP:0002486)2.20106801
105Hypobetalipoproteinemia (HP:0003563)2.19562840
106Mesangial abnormality (HP:0001966)2.18809334
107Epiphyseal stippling (HP:0010655)2.18701470
108Congenital stationary night blindness (HP:0007642)2.17632347
109Growth hormone excess (HP:0000845)2.17502591
110Lactic acidosis (HP:0003128)2.17468413
111Hypotelorism (HP:0000601)2.16552782
112Delayed epiphyseal ossification (HP:0002663)2.15773975
113Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14469523
114Bulbar palsy (HP:0001283)2.13391924
115Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13014989
116Myopathic facies (HP:0002058)2.12741104
117Thin bony cortex (HP:0002753)2.11632019
118Hamartoma (HP:0010566)2.10384929
119Abnormal epiphyseal ossification (HP:0010656)2.09334630
120Retinal dysplasia (HP:0007973)2.08987318
121Acute encephalopathy (HP:0006846)2.07445740
122Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07169904
123Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07169904
124Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06162202
125Abnormality of polysaccharide metabolism (HP:0011012)2.06162202
126Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06162202
127Hypotrichosis (HP:0001006)2.05819600
128Microvesicular hepatic steatosis (HP:0001414)2.05290100
129Exercise intolerance (HP:0003546)2.03406830
130Progressive muscle weakness (HP:0003323)2.03157727
131Short 5th finger (HP:0009237)2.01918720
132Optic disc pallor (HP:0000543)2.01789886
133Abnormality of the ileum (HP:0001549)2.00845093
134Constricted visual fields (HP:0001133)2.00457156
135Spinal muscular atrophy (HP:0007269)1.99146600
136Abnormality of the pancreatic islet cells (HP:0006476)1.98525576
137Abnormality of endocrine pancreas physiology (HP:0012093)1.98525576
138Acute necrotizing encephalopathy (HP:0006965)1.97925159
139Short thumb (HP:0009778)1.96564163
140Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96215384
141Abnormality of the labia minora (HP:0012880)1.95700098
142Polycythemia (HP:0001901)1.94948003
143Generalized amyotrophy (HP:0003700)1.94415004
144Dyschromatopsia (HP:0007641)1.92956149
145Vertebral fusion (HP:0002948)1.89409202
146Dysostosis multiplex (HP:0000943)1.88866411
147Opisthotonus (HP:0002179)1.88361133
148Amelogenesis imperfecta (HP:0000705)1.87635472
149Lower limb hyperreflexia (HP:0002395)1.87560752
150Severe muscular hypotonia (HP:0006829)1.86688716
151Cerebral hypomyelination (HP:0006808)1.86581512
152Birth length less than 3rd percentile (HP:0003561)1.86372587
153Hyperacusis (HP:0010780)1.84559289
154Volvulus (HP:0002580)1.84419863
155Neonatal respiratory distress (HP:0002643)1.84305515
156Sparse lateral eyebrow (HP:0005338)1.83865251
157Diminished movement (HP:0002374)1.83355117
158Methylmalonic aciduria (HP:0012120)1.83003522
159Pendular nystagmus (HP:0012043)1.79428870
160Flat capital femoral epiphysis (HP:0003370)1.79235408
161Abnormal rod and cone electroretinograms (HP:0008323)1.77701925
162Optic nerve coloboma (HP:0000588)1.77469796
163Dysmetric saccades (HP:0000641)1.77432104
164Entropion (HP:0000621)1.76798353
165Pancytopenia (HP:0001876)1.74698267
166Unilateral renal agenesis (HP:0000122)1.73785950
167Abnormality of dental color (HP:0011073)1.72702297
168Hyperglycinemia (HP:0002154)1.71718427
169Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71058901
170Absent epiphyses (HP:0010577)1.71058901
171Chorioretinal atrophy (HP:0000533)1.70470633
172Decreased central vision (HP:0007663)1.69370583
173Abnormality of the intrinsic pathway (HP:0010989)1.67871238
174Akinesia (HP:0002304)1.67544214
175Reduced antithrombin III activity (HP:0001976)1.66711229
176Stridor (HP:0010307)1.65783480
177Genetic anticipation (HP:0003743)1.64916333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.89751749
2MAPK154.68094589
3DDR24.40617216
4MAP3K64.26700369
5VRK24.12848663
6MAP3K113.75882912
7TRIB33.10446907
8PIM23.07762162
9PINK12.97389636
10MATK2.94001486
11SMG12.62883005
12IRAK32.55203771
13TYRO32.47235074
14DAPK12.41180036
15ARAF2.34095677
16FGR2.26548245
17YES12.25391324
18CDK72.18888218
19UHMK12.17044489
20BUB12.13288022
21PRKD32.11522271
22MUSK2.03577280
23SIK11.85681720
24CSK1.71835364
25PRKD21.71558048
26ZAK1.71483929
27DYRK1B1.68816164
28WEE11.66654942
29TESK11.62732914
30BMX1.60938539
31PDGFRA1.57833069
32PIM11.52243371
33MAP4K21.48444407
34MST1R1.43046724
35NME21.35313872
36RPS6KC11.35115895
37RPS6KL11.35115895
38PLK11.34478431
39CDC71.32735282
40MAP3K101.30141156
41CHEK21.28399703
42AKT31.26280392
43MAPKAPK31.24992449
44DYRK31.23124428
45LIMK11.20524446
46CDK61.18616949
47LATS21.17996866
48RPS6KA61.17183520
49PKN21.15313291
50MAPK111.10514378
51TRPM71.09387210
52BCKDK1.00883211
53CSNK1G31.00551359
54ACVR1B0.98256648
55TLK10.96892778
56ATR0.96888781
57ERN10.93738770
58LMTK20.93320285
59TAOK20.92397746
60CDC42BPA0.92380274
61RPS6KB20.92109019
62EEF2K0.91265025
63RPS6KA50.91036996
64EIF2AK10.89847651
65CCNB10.84420325
66AURKA0.83509917
67TAF10.81751877
68PBK0.81256250
69GSK3A0.80673153
70CSNK1A1L0.79394944
71NEK10.78913253
72WNK40.76683955
73SIK20.76674861
74AURKB0.76184600
75MAP2K20.75718788
76CDK80.75702253
77CSNK2A10.75273958
78NEK20.72758170
79ABL20.72459317
80RAF10.70689411
81SCYL20.69750793
82RPS6KA10.68084928
83TRIM280.67377606
84STK160.66434085
85DYRK20.64912600
86VRK10.64288927
87PHKG10.63506778
88PHKG20.63506778
89KDR0.62696284
90MAP2K70.62602570
91MAP2K30.60517105
92TTK0.60170464
93BRSK10.59934209
94CDK20.58909400
95BRSK20.58258478
96IRAK10.57436023
97GRK60.57050602
98SRPK10.55220059
99CSNK2A20.55077833
100MET0.54594767
101CAMKK10.52862718
102EIF2AK30.52266107
103CDK40.51256427
104FLT30.51231581
105MKNK10.51020368
106LYN0.50455661
107CDK90.49948652
108RPS6KA20.48621819
109AKT20.48597736
110MKNK20.47838319
111HIPK20.47451111
112CDK190.47279064
113CHEK10.46562304
114RPS6KB10.45635048
115DAPK30.44594446
116NUAK10.44270211
117PRPF4B0.44032480
118RPS6KA40.43147706
119CSNK1G20.42923631
120TESK20.42274398
121CDK11A0.42146373
122IRAK20.41647299
123GRK10.41198376
124MAP2K60.40715178
125ERBB30.40643270
126MTOR0.40466386
127ATM0.40028183
128PRKAA10.39387133
129CDK150.39097437
130PAK10.39094868
131PLK40.38320360
132MAPK40.37271214
133MAPK30.33932155
134PAK40.33781869
135PRKCI0.33698443
136MAP4K10.32025402
137CDK10.31617664
138EPHA20.28453249
139MAP3K80.27987913
140CAMK2G0.27642382
141CSNK1G10.27550730
142EGFR0.26594810
143ILK0.25048383
144MAPK10.23598381
145STK38L0.23502069
146NME10.23297980
147BRAF0.23291657
148MAPKAPK20.22632292
149MAPK140.21499626
150TGFBR10.19160974

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.22053840
2DNA replication_Homo sapiens_hsa030304.90184137
3Base excision repair_Homo sapiens_hsa034104.58437558
4Ribosome_Homo sapiens_hsa030103.20913700
5Fatty acid biosynthesis_Homo sapiens_hsa000613.00053397
6Nucleotide excision repair_Homo sapiens_hsa034202.84435420
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71093200
8Spliceosome_Homo sapiens_hsa030402.69591293
9Homologous recombination_Homo sapiens_hsa034402.50703735
10Proteasome_Homo sapiens_hsa030502.32865199
11RNA transport_Homo sapiens_hsa030132.31420144
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.03848328
13RNA polymerase_Homo sapiens_hsa030202.00393416
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92487049
15Fanconi anemia pathway_Homo sapiens_hsa034601.80022541
16Sulfur relay system_Homo sapiens_hsa041221.77298195
17Folate biosynthesis_Homo sapiens_hsa007901.75623233
18Cell cycle_Homo sapiens_hsa041101.73737952
19One carbon pool by folate_Homo sapiens_hsa006701.73383711
20Pyrimidine metabolism_Homo sapiens_hsa002401.69640575
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65356123
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.61971749
23mRNA surveillance pathway_Homo sapiens_hsa030151.60183215
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46775890
25* Biosynthesis of amino acids_Homo sapiens_hsa012301.44217737
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39144549
27p53 signaling pathway_Homo sapiens_hsa041151.34616682
28Sulfur metabolism_Homo sapiens_hsa009201.17552299
29RNA degradation_Homo sapiens_hsa030181.15994103
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12683048
31Fructose and mannose metabolism_Homo sapiens_hsa000511.11702994
32* Arginine and proline metabolism_Homo sapiens_hsa003301.11378009
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07985348
34Fatty acid metabolism_Homo sapiens_hsa012121.06180395
35Notch signaling pathway_Homo sapiens_hsa043301.03976687
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03914205
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.01016511
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00824603
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99139860
40Parkinsons disease_Homo sapiens_hsa050120.97254550
41Glutathione metabolism_Homo sapiens_hsa004800.97061754
42Hippo signaling pathway_Homo sapiens_hsa043900.96244692
43Hedgehog signaling pathway_Homo sapiens_hsa043400.96171298
44Circadian rhythm_Homo sapiens_hsa047100.93615593
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.93374204
46Oxidative phosphorylation_Homo sapiens_hsa001900.87587519
47Huntingtons disease_Homo sapiens_hsa050160.87055111
48Galactose metabolism_Homo sapiens_hsa000520.82487004
49Basal transcription factors_Homo sapiens_hsa030220.82026651
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.81689878
51Bladder cancer_Homo sapiens_hsa052190.79129690
52Vitamin B6 metabolism_Homo sapiens_hsa007500.76901037
53Non-homologous end-joining_Homo sapiens_hsa034500.76586503
54Phenylalanine metabolism_Homo sapiens_hsa003600.74887868
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73637067
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.71972535
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71771200
58TGF-beta signaling pathway_Homo sapiens_hsa043500.71763500
59Selenocompound metabolism_Homo sapiens_hsa004500.68464353
60mTOR signaling pathway_Homo sapiens_hsa041500.67544577
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67483171
62Carbon metabolism_Homo sapiens_hsa012000.65396272
63Basal cell carcinoma_Homo sapiens_hsa052170.64125971
64Peroxisome_Homo sapiens_hsa041460.61733683
65Arginine biosynthesis_Homo sapiens_hsa002200.60714379
66Lysine degradation_Homo sapiens_hsa003100.59222578
67N-Glycan biosynthesis_Homo sapiens_hsa005100.58527698
68Adherens junction_Homo sapiens_hsa045200.58376213
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57577725
70Purine metabolism_Homo sapiens_hsa002300.56183803
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55676718
72Oocyte meiosis_Homo sapiens_hsa041140.54719731
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54319582
74Sphingolipid metabolism_Homo sapiens_hsa006000.53275275
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53198693
76Primary immunodeficiency_Homo sapiens_hsa053400.52851010
77Steroid biosynthesis_Homo sapiens_hsa001000.52603073
78Shigellosis_Homo sapiens_hsa051310.52544976
79Other glycan degradation_Homo sapiens_hsa005110.52355598
80Fatty acid elongation_Homo sapiens_hsa000620.50596724
81Tyrosine metabolism_Homo sapiens_hsa003500.50350517
82Pyruvate metabolism_Homo sapiens_hsa006200.50316783
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46403630
84Legionellosis_Homo sapiens_hsa051340.46364599
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45832252
86Wnt signaling pathway_Homo sapiens_hsa043100.45787310
87Pentose phosphate pathway_Homo sapiens_hsa000300.45153154
88Epstein-Barr virus infection_Homo sapiens_hsa051690.44923851
89* Metabolic pathways_Homo sapiens_hsa011000.44736977
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44501105
91Thyroid cancer_Homo sapiens_hsa052160.43954404
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43366062
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41294576
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41195256
95Alcoholism_Homo sapiens_hsa050340.39861210
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.38819217
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38479535
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38196966
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35744272
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34090822
101Herpes simplex infection_Homo sapiens_hsa051680.32142218
102Vibrio cholerae infection_Homo sapiens_hsa051100.31782964
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31719886
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31633175
105Viral carcinogenesis_Homo sapiens_hsa052030.31450799
106Colorectal cancer_Homo sapiens_hsa052100.30933564
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.29088101
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28694624
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27990450
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27136572
111Alzheimers disease_Homo sapiens_hsa050100.26425501
112Protein export_Homo sapiens_hsa030600.26388698
113Phototransduction_Homo sapiens_hsa047440.25501695
114HTLV-I infection_Homo sapiens_hsa051660.25194371
115Systemic lupus erythematosus_Homo sapiens_hsa053220.24522427
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23674776
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23077423
118Propanoate metabolism_Homo sapiens_hsa006400.22879937
119Butanoate metabolism_Homo sapiens_hsa006500.22783639
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.22259870
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22216501
122MicroRNAs in cancer_Homo sapiens_hsa052060.21935011
123Fat digestion and absorption_Homo sapiens_hsa049750.20346371
124Tryptophan metabolism_Homo sapiens_hsa003800.20018470
125AMPK signaling pathway_Homo sapiens_hsa041520.18167100
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16743609
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16637724
128Lysosome_Homo sapiens_hsa041420.13400859

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