PYDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chemokine secretion (GO:0090196)9.72522355
2production of molecular mediator involved in inflammatory response (GO:0002532)9.33979425
3keratinization (GO:0031424)6.13421073
4amino sugar catabolic process (GO:0046348)6.10659018
5peptidyl-histidine modification (GO:0018202)5.91091467
6establishment of skin barrier (GO:0061436)5.42000794
7polysaccharide catabolic process (GO:0000272)5.22502242
8negative regulation of synaptic transmission, GABAergic (GO:0032229)4.88801828
9male meiosis I (GO:0007141)4.61811378
10snRNA transcription (GO:0009301)4.52610545
11ribosomal small subunit assembly (GO:0000028)4.51060743
12regulation of histone H3-K9 methylation (GO:0051570)4.39360119
13neurofilament cytoskeleton organization (GO:0060052)4.34659115
14anterior/posterior axis specification, embryo (GO:0008595)4.24473907
15negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.19783858
16opsonization (GO:0008228)4.17071198
17regulation of water loss via skin (GO:0033561)4.08564338
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.99159499
19proteasome assembly (GO:0043248)3.95338208
20regulation of rhodopsin mediated signaling pathway (GO:0022400)3.91696016
21microtubule severing (GO:0051013)3.91336294
22positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.86813270
23purine deoxyribonucleotide catabolic process (GO:0009155)3.86635421
24mitochondrial DNA metabolic process (GO:0032042)3.82373819
25negative regulation of macrophage differentiation (GO:0045650)3.81743291
26kinetochore assembly (GO:0051382)3.78435093
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.76954895
28negative regulation of nitric-oxide synthase activity (GO:0051001)3.72181156
29mitochondrial DNA replication (GO:0006264)3.72163890
30sex differentiation (GO:0007548)3.70795208
31activation of MAPKKK activity (GO:0000185)3.67072614
32glucosamine-containing compound metabolic process (GO:1901071)3.64285075
33keratinocyte development (GO:0003334)3.63852663
34electron transport chain (GO:0022900)3.57613950
35respiratory electron transport chain (GO:0022904)3.56857587
36rhodopsin mediated signaling pathway (GO:0016056)3.53860754
37termination of RNA polymerase III transcription (GO:0006386)3.51494395
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.51494395
39negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.48886455
40synaptic transmission, dopaminergic (GO:0001963)3.46800037
41meiosis I (GO:0007127)3.46543870
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.44379109
43embryonic body morphogenesis (GO:0010172)3.41941020
44regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.41347664
45DNA damage response, detection of DNA damage (GO:0042769)3.40820304
46regulation of retinoic acid receptor signaling pathway (GO:0048385)3.39774300
47protein complex biogenesis (GO:0070271)3.37379488
48viral transcription (GO:0019083)3.37318418
49cellular response to zinc ion (GO:0071294)3.36159739
50positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.32695986
51translational termination (GO:0006415)3.27828222
52rRNA methylation (GO:0031167)3.23767757
53cilium or flagellum-dependent cell motility (GO:0001539)3.19354909
54regulation of stem cell maintenance (GO:2000036)3.18117738
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.16867213
56NADH dehydrogenase complex assembly (GO:0010257)3.16867213
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16867213
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14937166
59positive regulation of ERBB signaling pathway (GO:1901186)3.11455294
60regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.07165751
61regulation of action potential (GO:0098900)3.06396549
62rRNA modification (GO:0000154)3.06382081
63regulation of cAMP-mediated signaling (GO:0043949)3.01018867
64kinetochore organization (GO:0051383)2.98037069
65DNA damage induced protein phosphorylation (GO:0006975)2.97934659
66neuron maturation (GO:0042551)2.95538692
67deoxyribonucleotide catabolic process (GO:0009264)2.94588964
68mitochondrial respiratory chain complex assembly (GO:0033108)2.94284020
69negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.93270775
70protein import into peroxisome matrix (GO:0016558)2.90977817
71response to fungus (GO:0009620)2.89392813
72intracellular protein transmembrane import (GO:0044743)2.89089899
73generation of neurons (GO:0048699)2.83998573
74intermediate filament organization (GO:0045109)2.83369358
75protein localization to cilium (GO:0061512)2.81710284
76regulation of helicase activity (GO:0051095)2.76498397
77deoxyribose phosphate catabolic process (GO:0046386)2.76316014
78negative regulation of transcription by competitive promoter binding (GO:0010944)2.76261616
79oxidative phosphorylation (GO:0006119)2.74914425
80energy coupled proton transport, down electrochemical gradient (GO:0015985)2.74525661
81ATP synthesis coupled proton transport (GO:0015986)2.74525661
82misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.73655692
83cornea development in camera-type eye (GO:0061303)2.73244022
84cellular protein complex disassembly (GO:0043624)2.72951383
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72300279
86body morphogenesis (GO:0010171)2.69189161
87purine deoxyribonucleotide metabolic process (GO:0009151)2.66743779
88mitochondrial genome maintenance (GO:0000002)2.64221202
89respiratory chain complex IV assembly (GO:0008535)2.63398379
90positive regulation of glomerulus development (GO:0090193)2.63214181
91intracellular protein transmembrane transport (GO:0065002)2.62788556
92regulation of nuclear cell cycle DNA replication (GO:0033262)2.60270054
93maturation of SSU-rRNA (GO:0030490)2.59781380
94peroxisome fission (GO:0016559)2.59752527
95regulation of gene expression by genetic imprinting (GO:0006349)2.57301518
96DNA deamination (GO:0045006)2.55970106
97protein transmembrane transport (GO:0071806)2.55004068
98cell wall macromolecule metabolic process (GO:0044036)14.1735042
99positive regulation of chemokine secretion (GO:0090197)11.0806262
100glucosamine-containing compound catabolic process (GO:1901072)10.6394155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.56091113
2EZH2_22144423_ChIP-Seq_EOC_Human4.90964910
3ZNF274_21170338_ChIP-Seq_K562_Hela3.71206449
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79216489
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.76352326
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.47991327
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46427341
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38467306
9CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.37624327
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.28072182
11VDR_22108803_ChIP-Seq_LS180_Human2.16318022
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15060069
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11491772
14TP63_17297297_ChIP-ChIP_HaCaT_Human1.87841512
15YY1_22570637_ChIP-Seq_MALME-3M_Human1.82576996
16EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.77676774
17ESR1_15608294_ChIP-ChIP_MCF-7_Human1.74224382
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74114305
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73682735
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69497653
21SOX2_16153702_ChIP-ChIP_HESCs_Human1.63093128
22YY1_21170310_ChIP-Seq_MESCs_Mouse1.61649539
23IGF1R_20145208_ChIP-Seq_DFB_Human1.61219426
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61216690
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60608183
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.59358852
27FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.53628757
28P53_21459846_ChIP-Seq_SAOS-2_Human1.53269873
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.52804133
30BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.52479073
31REST_21632747_ChIP-Seq_MESCs_Mouse1.52341999
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48462091
33CTCF_27219007_Chip-Seq_Bcells_Human1.48238266
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47698612
35GATA6_21074721_ChIP-Seq_CACO-2_Human1.45922356
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45842320
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.44203012
38GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.43005521
39VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.40455955
40CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.39745011
41CIITA_25753668_ChIP-Seq_RAJI_Human1.33231521
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.33032276
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29077038
44SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27501716
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25951939
46ETV1_20927104_ChIP-Seq_GIST48_Human1.24569652
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23144856
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22942104
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.22884397
50RBPJ_21746931_ChIP-Seq_IB4_Human1.22706200
51ERG_20517297_ChIP-Seq_VCAP_Human1.22477733
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20325764
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18024026
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.17411123
55PHF8_20622854_ChIP-Seq_HELA_Human1.16747057
56E2F1_20622854_ChIP-Seq_HELA_Human1.16630368
57* NCOR_22424771_ChIP-Seq_293T_Human1.14242936
58* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14196967
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13206008
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12107214
61BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.11772348
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10096718
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07221292
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.06692509
65TP53_22573176_ChIP-Seq_HFKS_Human1.05938908
66GABP_19822575_ChIP-Seq_HepG2_Human1.04109144
67HNFA_21074721_ChIP-Seq_CACO-2_Human1.03637300
68DCP1A_22483619_ChIP-Seq_HELA_Human1.03304131
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03189298
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99528123
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98968786
72NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98293731
73WDR5_24793694_ChIP-Seq_LNCAP_Human0.98210423
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97454009
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95884170
76MYC_19829295_ChIP-Seq_ESCs_Human0.95166511
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94801277
78TTF2_22483619_ChIP-Seq_HELA_Human0.92531152
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92349324
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92264902
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92197037
82RNF2_27304074_Chip-Seq_NSC_Mouse0.92084882
83SA1_27219007_Chip-Seq_Bcells_Human0.91577276
84P68_20966046_ChIP-Seq_HELA_Human0.90736625
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90615918
86EZH2_27294783_Chip-Seq_ESCs_Mouse0.90388661
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88315011
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88239635
89FOXH1_21741376_ChIP-Seq_ESCs_Human0.87966661
90OCT4_19829295_ChIP-Seq_ESCs_Human0.87821915
91SRF_21415370_ChIP-Seq_HL-1_Mouse0.87550021
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.87440254
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.87070686
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86439184
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86077958
96JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85661216
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83803641
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.83803641
99DPY_21335234_ChIP-Seq_ESCs_Mouse0.83024633
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82811321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.54997213
2MP0003787_abnormal_imprinting4.64334070
3MP0009379_abnormal_foot_pigmentation3.91316215
4MP0000579_abnormal_nail_morphology3.73344603
5MP0002796_impaired_skin_barrier3.52826367
6MP0003123_paternal_imprinting3.44571163
7MP0005275_abnormal_skin_tensile3.17187310
8MP0005408_hypopigmentation2.88548682
9MP0003941_abnormal_skin_development2.70043235
10MP0004147_increased_porphyrin_level2.67066972
11MP0006292_abnormal_olfactory_placode2.55633633
12MP0001661_extended_life_span2.32268825
13MP0008877_abnormal_DNA_methylation2.31538571
14MP0001188_hyperpigmentation2.16890561
15MP0002138_abnormal_hepatobiliary_system2.12749374
16MP0008260_abnormal_autophagy2.05569850
17MP0005551_abnormal_eye_electrophysiolog2.05133725
18MP0000427_abnormal_hair_cycle1.90253019
19MP0002098_abnormal_vibrissa_morphology1.86926036
20MP0004270_analgesia1.79864027
21MP0005501_abnormal_skin_physiology1.74647581
22MP0002163_abnormal_gland_morphology1.72359235
23MP0003880_abnormal_central_pattern1.70007452
24MP0005423_abnormal_somatic_nervous1.68239698
25MP0003121_genomic_imprinting1.65806483
26MP0006276_abnormal_autonomic_nervous1.56861128
27MP0002734_abnormal_mechanical_nocicepti1.52725647
28MP0002095_abnormal_skin_pigmentation1.48607076
29MP0008872_abnormal_physiological_respon1.48051955
30MP0003119_abnormal_digestive_system1.47497005
31MP0001764_abnormal_homeostasis1.46011679
32MP0005377_hearing/vestibular/ear_phenot1.42545671
33MP0003878_abnormal_ear_physiology1.42545671
34MP0005257_abnormal_intraocular_pressure1.40419192
35MP0006036_abnormal_mitochondrial_physio1.38683913
36MP0004859_abnormal_synaptic_plasticity1.37876114
37MP0005646_abnormal_pituitary_gland1.37395012
38MP0001486_abnormal_startle_reflex1.34133908
39MP0002837_dystrophic_cardiac_calcinosis1.27869464
40MP0000383_abnormal_hair_follicle1.27377396
41MP0002064_seizures1.22852828
42MP0003646_muscle_fatigue1.22265886
43MP0005645_abnormal_hypothalamus_physiol1.21943455
44MP0009745_abnormal_behavioral_response1.21553821
45MP0003567_abnormal_fetal_cardiomyocyte1.19523109
46MP0000631_abnormal_neuroendocrine_gland1.17929206
47MP0003890_abnormal_embryonic-extraembry1.15442702
48MP0001970_abnormal_pain_threshold1.13159219
49MP0005075_abnormal_melanosome_morpholog1.13158883
50MP0001485_abnormal_pinna_reflex1.13122737
51MP0004145_abnormal_muscle_electrophysio1.11806290
52MP0003635_abnormal_synaptic_transmissio1.10966755
53MP0008995_early_reproductive_senescence1.10641463
54MP0004742_abnormal_vestibular_system1.10504502
55MP0010030_abnormal_orbit_morphology1.06851802
56MP0004381_abnormal_hair_follicle1.03120627
57MP0000377_abnormal_hair_follicle1.00500198
58MP0001968_abnormal_touch/_nociception0.99684878
59MP0010771_integument_phenotype0.96937175
60MP0002572_abnormal_emotion/affect_behav0.95967633
61MP0000647_abnormal_sebaceous_gland0.95775037
62MP0009046_muscle_twitch0.93968219
63MP0010678_abnormal_skin_adnexa0.93500749
64MP0002733_abnormal_thermal_nociception0.92334382
65MP0002752_abnormal_somatic_nervous0.92149495
66MP0002638_abnormal_pupillary_reflex0.89534726
67MP0002272_abnormal_nervous_system0.89423657
68MP0000751_myopathy0.88463461
69MP0003111_abnormal_nucleus_morphology0.84400580
70MP0000749_muscle_degeneration0.84211434
71MP0005379_endocrine/exocrine_gland_phen0.80938129
72MP0000367_abnormal_coat/_hair0.80171936
73MP0001529_abnormal_vocalization0.79383714
74MP0004084_abnormal_cardiac_muscle0.79280658
75MP0001299_abnormal_eye_distance/0.78893596
76MP0004957_abnormal_blastocyst_morpholog0.77826701
77MP0002882_abnormal_neuron_morphology0.77054111
78MP0006035_abnormal_mitochondrial_morpho0.76930105
79MP0000639_abnormal_adrenal_gland0.76742194
80MP0003698_abnormal_male_reproductive0.76163603
81MP0002735_abnormal_chemical_nociception0.75608903
82MP0004885_abnormal_endolymph0.73254203
83MP0003936_abnormal_reproductive_system0.73046566
84MP0001216_abnormal_epidermal_layer0.72897538
85MP0002210_abnormal_sex_determination0.71532989
86MP0002063_abnormal_learning/memory/cond0.71424815
87MP0005195_abnormal_posterior_eye0.71311918
88MP0000358_abnormal_cell_content/0.69853677
89MP0006072_abnormal_retinal_apoptosis0.69169468
90MP0002067_abnormal_sensory_capabilities0.68554482
91MP0000372_irregular_coat_pigmentation0.64710249
92MP0002277_abnormal_respiratory_mucosa0.64299619
93MP0001191_abnormal_skin_condition0.62416767
94MP0001145_abnormal_male_reproductive0.60336405
95MP0005535_abnormal_body_temperature0.59252766
96MP0001293_anophthalmia0.59123534
97MP0000778_abnormal_nervous_system0.56747000
98MP0001963_abnormal_hearing_physiology0.56665661
99MP0001881_abnormal_mammary_gland0.56345543
100MP0009672_abnormal_birth_weight0.55779191

Predicted human phenotypes

RankGene SetZ-score
1Diastasis recti (HP:0001540)5.51446544
2Pili torti (HP:0003777)4.93905309
3Attenuation of retinal blood vessels (HP:0007843)4.54272020
4Neoplasm of the adrenal cortex (HP:0100641)4.20462412
5Neonatal hypoglycemia (HP:0001998)3.94298105
6Follicular hyperkeratosis (HP:0007502)3.88252911
7Myokymia (HP:0002411)3.87801116
8Hepatoblastoma (HP:0002884)3.78949668
9Abnormality of nail color (HP:0100643)3.77621878
10Genetic anticipation (HP:0003743)3.63515608
11Acute necrotizing encephalopathy (HP:0006965)3.60308840
12Sparse lateral eyebrow (HP:0005338)3.56711225
13Erythroderma (HP:0001019)3.44451391
14Progressive cerebellar ataxia (HP:0002073)3.39926230
15Adrenal hypoplasia (HP:0000835)3.39169003
16Congenital ichthyosiform erythroderma (HP:0007431)3.31085062
17Abnormal hair laboratory examination (HP:0003328)3.25378462
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.21201925
19Abnormal mitochondria in muscle tissue (HP:0008316)3.16594824
20Optic disc pallor (HP:0000543)3.02964790
21Woolly hair (HP:0002224)2.91941819
22Congenital, generalized hypertrichosis (HP:0004540)2.91153982
23Impaired vibration sensation in the lower limbs (HP:0002166)2.90339067
24Parakeratosis (HP:0001036)2.90281514
25Acute encephalopathy (HP:0006846)2.86695242
26Lip pit (HP:0100267)2.85041247
27Urinary urgency (HP:0000012)2.80233668
28Mitochondrial inheritance (HP:0001427)2.79295806
29Myopathic facies (HP:0002058)2.78638854
30Progressive macrocephaly (HP:0004481)2.73651415
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.72721156
323-Methylglutaconic aciduria (HP:0003535)2.68538795
33Erythema (HP:0010783)2.68214971
34Cerebral edema (HP:0002181)2.65299404
35Reticulocytopenia (HP:0001896)2.55602980
36Microvesicular hepatic steatosis (HP:0001414)2.53896037
37Oral leukoplakia (HP:0002745)2.50520096
38Increased hepatocellular lipid droplets (HP:0006565)2.49323825
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48552020
40Overgrowth (HP:0001548)2.45907257
41Abnormal pancreas size (HP:0012094)2.44382125
42Colon cancer (HP:0003003)2.42584366
43Increased CSF lactate (HP:0002490)2.38251698
44Methylmalonic acidemia (HP:0002912)2.38218238
45Sparse eyelashes (HP:0000653)2.37011401
46Lipid accumulation in hepatocytes (HP:0006561)2.36033200
47Chronic sinusitis (HP:0011109)2.32771234
48Neoplasm of the adrenal gland (HP:0100631)2.31622049
49Sensory axonal neuropathy (HP:0003390)2.31368048
50Tubulointerstitial nephritis (HP:0001970)2.28843809
51Decreased central vision (HP:0007663)2.28151479
52Abnormal rod and cone electroretinograms (HP:0008323)2.27353534
53Hypoparathyroidism (HP:0000829)2.25465967
54Clumsiness (HP:0002312)2.21811131
55Urinary bladder sphincter dysfunction (HP:0002839)2.16921786
56Abnormal number of incisors (HP:0011064)2.14775064
57Nemaline bodies (HP:0003798)2.11182348
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10692924
59Ectropion (HP:0000656)2.09247019
60Renal Fanconi syndrome (HP:0001994)2.03243092
61Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.02990227
62Exercise intolerance (HP:0003546)2.01592162
63Muscle fiber inclusion bodies (HP:0100299)2.00131726
64Hypotrichosis (HP:0001006)1.99551008
65X-linked dominant inheritance (HP:0001423)1.96830145
66Slow-growing hair (HP:0002217)1.96320245
67Abnormality of hair growth rate (HP:0011363)1.96320245
68Infantile muscular hypotonia (HP:0008947)1.93771270
69Respiratory difficulties (HP:0002880)1.92288704
70Abnormality of DNA repair (HP:0003254)1.91617860
71Absent hand (HP:0004050)1.90737224
72Ankle clonus (HP:0011448)1.89423890
73Pancreatic cysts (HP:0001737)1.87080366
74Deep philtrum (HP:0002002)1.86596442
75Poor suck (HP:0002033)1.86322974
76Pallor (HP:0000980)1.85870142
77Prolonged QT interval (HP:0001657)1.81797286
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80842774
79Macrocytic anemia (HP:0001972)1.77919206
80Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76177337
81Degeneration of the lateral corticospinal tracts (HP:0002314)1.76177337
82Severe Myopia (HP:0011003)1.75484109
83Spastic paraparesis (HP:0002313)1.74843417
84Lactic acidosis (HP:0003128)1.74779190
85Microretrognathia (HP:0000308)1.73299042
86Ulnar claw (HP:0001178)1.72703914
87Neoplasm of the oral cavity (HP:0100649)1.72311507
88Tetany (HP:0001281)1.72103240
89Abnormality of the septum pellucidum (HP:0007375)1.71142976
90Increased IgE level (HP:0003212)1.71133642
91Basal cell carcinoma (HP:0002671)1.70802843
92Methylmalonic aciduria (HP:0012120)1.70585366
93Median cleft lip (HP:0000161)1.70562539
94Abnormal biliary tract physiology (HP:0012439)1.69602070
95Bile duct proliferation (HP:0001408)1.69602070
96Growth hormone deficiency (HP:0000824)1.69331442
97Brittle hair (HP:0002299)1.68926613
98Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67625831
99Malignant hyperthermia (HP:0002047)1.67273885
100Abnormal number of erythroid precursors (HP:0012131)1.66594163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.93773329
2MAP2K43.17868329
3NME12.92545966
4GRK12.78871119
5ZAK2.64228064
6MAP4K12.59378151
7EPHA42.49357085
8PBK2.45935300
9TNIK2.37742265
10ADRBK12.29177162
11PHKG12.24889236
12PHKG22.24889236
13DYRK22.21476993
14PIK3CG2.12601771
15BCKDK2.12441275
16EPHA22.11490221
17MINK12.03410146
18BCR1.96862470
19MAP3K51.92638649
20PRPF4B1.91490969
21MAPKAPK31.77359338
22LIMK11.68113609
23NTRK31.67250496
24TLK11.65842151
25MAP3K91.59996713
26MAP3K111.59166791
27MAP3K41.56511163
28TAOK21.41791880
29SIK21.40851118
30CSNK1G11.34986857
31OBSCN1.20802983
32MST41.15477902
33MAP2K71.12136179
34CHEK21.11403917
35TESK21.07475962
36MAP2K31.06735712
37TAF11.04359136
38CDK121.03123171
39TTK1.01176637
40CSNK1E1.00255159
41PAK60.99155313
42VRK20.98894078
43CSNK1G20.94639624
44CSNK1G30.93934764
45CSF1R0.93786640
46MAP2K60.93433174
47CASK0.87633199
48CAMK1D0.87111185
49MAPK130.86354331
50CDK190.85471534
51CSNK1A1L0.84589217
52DAPK10.81971241
53MAPK120.79264417
54ERBB20.78396171
55ABL20.78328964
56BMPR1B0.70675325
57DAPK30.68085258
58MUSK0.67124163
59PDK10.66933389
60GRK50.66654338
61PASK0.65907475
62CAMKK10.63355488
63BRD40.61649116
64NUAK10.58709069
65ATR0.58024860
66PLK10.56949371
67VRK10.56775651
68IRAK30.56416506
69DAPK20.56243342
70TYRO30.51298355
71DYRK30.51298075
72MKNK20.50595089
73NEK20.49098751
74LATS20.47153171
75PRKCQ0.46534808
76PLK30.46172495
77WNK30.44549115
78MELK0.42106119
79TNK20.40899859
80MAP3K60.39804857
81BUB10.38369800
82CDK50.36947935
83SGK10.36518904
84RPS6KB10.35405115
85CAMKK20.35062452
86EIF2AK10.34948780
87CDK90.34391799
88AURKA0.33094933
89DYRK1A0.32863023
90CAMK2A0.30235820
91OXSR10.29776498
92PRKD10.29193089
93ACVR1B0.29107995
94CDK20.27830649
95DMPK0.27706151
96CSNK2A20.27078035
97PINK10.26780360
98MAPK140.24961610
99HIPK20.24902866
100CAMK10.22726287

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.53660279
2Ribosome_Homo sapiens_hsa030104.02765081
3Oxidative phosphorylation_Homo sapiens_hsa001903.48186276
4RNA polymerase_Homo sapiens_hsa030203.03144604
5Mismatch repair_Homo sapiens_hsa034302.95085283
6Parkinsons disease_Homo sapiens_hsa050122.88277414
7Cardiac muscle contraction_Homo sapiens_hsa042602.79873565
8Nicotine addiction_Homo sapiens_hsa050332.55829938
9Huntingtons disease_Homo sapiens_hsa050162.20941084
10Alzheimers disease_Homo sapiens_hsa050102.18389213
11Nitrogen metabolism_Homo sapiens_hsa009101.87639449
12Arginine biosynthesis_Homo sapiens_hsa002201.86937036
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.85963116
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.70807648
15Proteasome_Homo sapiens_hsa030501.55686997
16Synaptic vesicle cycle_Homo sapiens_hsa047211.53159096
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47412200
18Basal transcription factors_Homo sapiens_hsa030221.43802505
19Sulfur relay system_Homo sapiens_hsa041221.40957233
20Linoleic acid metabolism_Homo sapiens_hsa005911.38916485
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38326907
22Pyrimidine metabolism_Homo sapiens_hsa002401.31730966
23Glutamatergic synapse_Homo sapiens_hsa047241.31225164
24Homologous recombination_Homo sapiens_hsa034401.30747598
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26892530
26Thyroid cancer_Homo sapiens_hsa052161.25523727
27Purine metabolism_Homo sapiens_hsa002301.24855594
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24708703
29Collecting duct acid secretion_Homo sapiens_hsa049661.17505991
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17384392
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14543105
32GABAergic synapse_Homo sapiens_hsa047271.12605714
33Amphetamine addiction_Homo sapiens_hsa050311.09812881
34RNA degradation_Homo sapiens_hsa030181.09295849
35Circadian rhythm_Homo sapiens_hsa047101.08893982
36Olfactory transduction_Homo sapiens_hsa047401.06382996
37Spliceosome_Homo sapiens_hsa030401.06134623
38Selenocompound metabolism_Homo sapiens_hsa004501.02276670
39Vitamin B6 metabolism_Homo sapiens_hsa007501.01626237
40Cocaine addiction_Homo sapiens_hsa050301.01322472
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99849352
42Fanconi anemia pathway_Homo sapiens_hsa034600.96898806
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96579788
44Circadian entrainment_Homo sapiens_hsa047130.95563265
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95475087
46Oocyte meiosis_Homo sapiens_hsa041140.92010557
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88919491
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.87051519
49Basal cell carcinoma_Homo sapiens_hsa052170.86764476
50Dopaminergic synapse_Homo sapiens_hsa047280.85159977
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84413957
52Hedgehog signaling pathway_Homo sapiens_hsa043400.81819880
53Taste transduction_Homo sapiens_hsa047420.77628234
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76944532
55Mineral absorption_Homo sapiens_hsa049780.73865300
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70921676
57Morphine addiction_Homo sapiens_hsa050320.70756936
58Wnt signaling pathway_Homo sapiens_hsa043100.69501348
59Calcium signaling pathway_Homo sapiens_hsa040200.65804519
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65465524
61Melanogenesis_Homo sapiens_hsa049160.64177982
62Long-term potentiation_Homo sapiens_hsa047200.63754930
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62686043
64Long-term depression_Homo sapiens_hsa047300.61390179
65RNA transport_Homo sapiens_hsa030130.59661928
66Serotonergic synapse_Homo sapiens_hsa047260.59567569
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56768976
68Hippo signaling pathway_Homo sapiens_hsa043900.54005970
69mRNA surveillance pathway_Homo sapiens_hsa030150.53748364
70Salivary secretion_Homo sapiens_hsa049700.51145195
71MAPK signaling pathway_Homo sapiens_hsa040100.50865350
72Alcoholism_Homo sapiens_hsa050340.50754625
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49894987
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48429819
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46856480
76p53 signaling pathway_Homo sapiens_hsa041150.46430250
77Nucleotide excision repair_Homo sapiens_hsa034200.46019030
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45633502
79Propanoate metabolism_Homo sapiens_hsa006400.44848810
80Fatty acid elongation_Homo sapiens_hsa000620.44723663
81Cell cycle_Homo sapiens_hsa041100.44628396
82Epstein-Barr virus infection_Homo sapiens_hsa051690.44236031
83Insulin secretion_Homo sapiens_hsa049110.44132728
84Axon guidance_Homo sapiens_hsa043600.43827493
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42717895
86Fat digestion and absorption_Homo sapiens_hsa049750.39792629
87DNA replication_Homo sapiens_hsa030300.39382823
88Oxytocin signaling pathway_Homo sapiens_hsa049210.39341188
89Renin-angiotensin system_Homo sapiens_hsa046140.36598207
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34013259
91Ether lipid metabolism_Homo sapiens_hsa005650.33733188
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33637894
93Ovarian steroidogenesis_Homo sapiens_hsa049130.32557506
94Metabolic pathways_Homo sapiens_hsa011000.32544870
95Ras signaling pathway_Homo sapiens_hsa040140.32450741
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30800356
97Cholinergic synapse_Homo sapiens_hsa047250.30681192
98Base excision repair_Homo sapiens_hsa034100.30374409
99Regulation of autophagy_Homo sapiens_hsa041400.29453908
100Tight junction_Homo sapiens_hsa045300.29228441

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