PYGL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.75950465
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.75950465
3L-phenylalanine metabolic process (GO:0006558)6.46605667
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.46605667
5aromatic amino acid family catabolic process (GO:0009074)6.12702812
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.98648753
7neutrophil activation involved in immune response (GO:0002283)5.62509752
8indole-containing compound catabolic process (GO:0042436)5.57659092
9indolalkylamine catabolic process (GO:0046218)5.57659092
10tryptophan catabolic process (GO:0006569)5.57659092
11alpha-linolenic acid metabolic process (GO:0036109)5.55004950
12complement activation, alternative pathway (GO:0006957)5.50748011
13urea metabolic process (GO:0019627)5.48353860
14urea cycle (GO:0000050)5.48353860
15kynurenine metabolic process (GO:0070189)5.47001543
16bile acid biosynthetic process (GO:0006699)5.45935266
17peptidyl-glutamic acid carboxylation (GO:0017187)5.31262036
18protein carboxylation (GO:0018214)5.31262036
19negative regulation of fibrinolysis (GO:0051918)5.28743677
20glyoxylate metabolic process (GO:0046487)5.26858992
21high-density lipoprotein particle remodeling (GO:0034375)5.26603133
22tryptophan metabolic process (GO:0006568)5.24402831
23regulation of protein activation cascade (GO:2000257)5.17885539
24sulfur amino acid catabolic process (GO:0000098)5.09495910
25nitrogen cycle metabolic process (GO:0071941)5.03737410
26regulation of fibrinolysis (GO:0051917)5.02497533
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.95529687
28positive regulation by organism of defense response of other organism involved in symbiotic interact4.95529687
29modulation by symbiont of host immune response (GO:0052553)4.95529687
30positive regulation by symbiont of host defense response (GO:0052509)4.95529687
31modulation by symbiont of host defense response (GO:0052031)4.95529687
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.95529687
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.94589242
34regulation of triglyceride catabolic process (GO:0010896)4.92574882
35response to peptidoglycan (GO:0032494)4.91247451
36regulation of complement activation (GO:0030449)4.88162617
37cysteine metabolic process (GO:0006534)4.87048935
38detection of molecule of bacterial origin (GO:0032490)4.76467027
39reverse cholesterol transport (GO:0043691)4.68404220
40bile acid metabolic process (GO:0008206)4.65135242
41protein-lipid complex remodeling (GO:0034368)4.64815127
42macromolecular complex remodeling (GO:0034367)4.64815127
43plasma lipoprotein particle remodeling (GO:0034369)4.64815127
44plasma lipoprotein particle clearance (GO:0034381)4.56049053
45serine family amino acid catabolic process (GO:0009071)4.55560734
46regulation of cholesterol esterification (GO:0010872)4.51517175
47phospholipid efflux (GO:0033700)4.49149293
48detection of other organism (GO:0098543)4.49004419
49aromatic amino acid family metabolic process (GO:0009072)4.41474520
50amino-acid betaine metabolic process (GO:0006577)4.40530798
51triglyceride homeostasis (GO:0070328)4.39849738
52acylglycerol homeostasis (GO:0055090)4.39849738
53leukocyte migration involved in inflammatory response (GO:0002523)4.34398567
54tyrosine metabolic process (GO:0006570)4.31053476
55detection of external biotic stimulus (GO:0098581)4.29233797
56lysine catabolic process (GO:0006554)4.28422942
57lysine metabolic process (GO:0006553)4.28422942
58homocysteine metabolic process (GO:0050667)4.28008962
59alpha-amino acid catabolic process (GO:1901606)4.18974189
60negative regulation of sterol transport (GO:0032372)4.16611694
61negative regulation of cholesterol transport (GO:0032375)4.16611694
62imidazole-containing compound metabolic process (GO:0052803)4.15596535
63macrophage activation involved in immune response (GO:0002281)4.11963436
64detection of bacterium (GO:0016045)4.09861854
65ethanol oxidation (GO:0006069)4.04238726
66cholesterol efflux (GO:0033344)4.02058572
67bile acid and bile salt transport (GO:0015721)4.01305683
68phospholipid homeostasis (GO:0055091)4.00042950
69plasma lipoprotein particle assembly (GO:0034377)3.99524095
70low-density lipoprotein particle remodeling (GO:0034374)3.95507301
71cellular extravasation (GO:0045123)3.94712624
72positive regulation of lipid catabolic process (GO:0050996)3.94600217
73neutrophil activation (GO:0042119)3.92622853
74indolalkylamine metabolic process (GO:0006586)3.91399233
75cellular glucuronidation (GO:0052695)3.90255073
76glycine metabolic process (GO:0006544)3.90102693
77killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.89470451
78disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.89470451
79cellular ketone body metabolic process (GO:0046950)3.87184338
80cellular amino acid catabolic process (GO:0009063)3.86584844
81coenzyme catabolic process (GO:0009109)3.85959549
82fibrinolysis (GO:0042730)3.84506564
83cellular biogenic amine catabolic process (GO:0042402)3.82026333
84amine catabolic process (GO:0009310)3.82026333
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.81898320
86benzene-containing compound metabolic process (GO:0042537)3.76213543
87aldehyde catabolic process (GO:0046185)3.76175990
88detection of biotic stimulus (GO:0009595)3.75679800
89positive regulation of lipoprotein lipase activity (GO:0051006)3.73743061
90positive regulation of triglyceride lipase activity (GO:0061365)3.73743061
91arginine metabolic process (GO:0006525)3.72299595
92complement activation (GO:0006956)3.71471675
93regulation of myeloid leukocyte mediated immunity (GO:0002886)3.71435491
94positive regulation of gamma-delta T cell activation (GO:0046645)3.71204288
95regulation of mast cell degranulation (GO:0043304)3.70170740
96serine family amino acid metabolic process (GO:0009069)3.69340007
97acetyl-CoA metabolic process (GO:0006084)3.69171142
98plasma lipoprotein particle organization (GO:0071827)3.68559116
99negative regulation of cell killing (GO:0031342)3.67922393
100negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.67922393
101protein activation cascade (GO:0072376)3.66859475
102glutamate metabolic process (GO:0006536)3.66571854
103negative regulation of interleukin-12 production (GO:0032695)3.65068153
104very-low-density lipoprotein particle assembly (GO:0034379)3.64897319
105granulocyte activation (GO:0036230)3.64502344
106complement activation, classical pathway (GO:0006958)3.63144537
107cellular modified amino acid catabolic process (GO:0042219)3.61794495
108blood coagulation, intrinsic pathway (GO:0007597)3.61637246
109positive regulation of fatty acid beta-oxidation (GO:0032000)3.60536041
110cholesterol homeostasis (GO:0042632)3.60345804
111protein-lipid complex assembly (GO:0065005)3.59419980
112dicarboxylic acid biosynthetic process (GO:0043650)3.58230432
113negative regulation of lipase activity (GO:0060192)3.56738260
114regulation of leukocyte degranulation (GO:0043300)3.55677332
115sterol homeostasis (GO:0055092)3.54182265
116positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.52622835
117regulation of interferon-beta biosynthetic process (GO:0045357)3.52537578
118opsonization (GO:0008228)3.51794603
119carboxylic acid catabolic process (GO:0046395)3.50649563
120organic acid catabolic process (GO:0016054)3.50649563
121cofactor catabolic process (GO:0051187)3.50515024
122low-density lipoprotein particle clearance (GO:0034383)3.50235983
123fatty acid oxidation (GO:0019395)3.49950072
124fatty acid beta-oxidation (GO:0006635)3.49096727
125response to host immune response (GO:0052572)3.47974304
126response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.47974304
127protein-lipid complex subunit organization (GO:0071825)3.47270597
128serine family amino acid biosynthetic process (GO:0009070)3.46986284
129positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.46711508
130glucuronate metabolic process (GO:0019585)3.46245055
131uronic acid metabolic process (GO:0006063)3.46245055
132short-chain fatty acid metabolic process (GO:0046459)3.45055913
133regulation of mast cell activation involved in immune response (GO:0033006)3.43837522
134antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.42993465
135leukocyte aggregation (GO:0070486)3.41917711
136antigen processing and presentation of endogenous antigen (GO:0019883)3.40092970
137response to host (GO:0075136)3.39348716
138response to host defenses (GO:0052200)3.39348716
139response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.39348716
140respiratory burst (GO:0045730)3.29580308
141microglial cell activation (GO:0001774)3.29338742
142positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.27943110
143positive regulation of mast cell activation (GO:0033005)3.17663854
144myeloid cell activation involved in immune response (GO:0002275)3.17306325
145macrophage activation (GO:0042116)3.16859620
146positive regulation of leukocyte degranulation (GO:0043302)3.13882010
147pinocytosis (GO:0006907)3.11334942
148lipopolysaccharide-mediated signaling pathway (GO:0031663)3.07704926
149regulation of superoxide anion generation (GO:0032928)3.07646601
150negative regulation of erythrocyte differentiation (GO:0045647)3.05907050
151positive regulation of mast cell degranulation (GO:0043306)3.03701029
152positive regulation of mast cell activation involved in immune response (GO:0033008)3.03701029
153antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.01009221
154hypotonic response (GO:0006971)2.97290984
155neutrophil mediated immunity (GO:0002446)2.96714807
156immunoglobulin mediated immune response (GO:0016064)2.90339523
157production of molecular mediator involved in inflammatory response (GO:0002532)2.88007997
158regulation of mast cell activation (GO:0033003)2.87253616
159positive regulation of Cdc42 GTPase activity (GO:0043089)2.87219230
160pentose-phosphate shunt (GO:0006098)2.85806186
161negative regulation of lymphocyte mediated immunity (GO:0002707)2.85759933
162response to muramyl dipeptide (GO:0032495)2.82028420
163antigen processing and presentation via MHC class Ib (GO:0002475)2.80718745
164regulation of regulated secretory pathway (GO:1903305)2.80691325
165negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.77979245
166leukocyte degranulation (GO:0043299)2.76650730
167positive regulation of cellular amide metabolic process (GO:0034250)2.75611276
168positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.71219648
169protein localization to endosome (GO:0036010)2.66423363
170positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.66273612
171positive regulation of regulated secretory pathway (GO:1903307)2.66038320
172negative regulation of phagocytosis (GO:0050765)2.61895318
173hemidesmosome assembly (GO:0031581)2.60827587
174negative regulation of leukocyte mediated immunity (GO:0002704)2.58966085
175NADPH regeneration (GO:0006740)2.56379984
176barbed-end actin filament capping (GO:0051016)2.56111449
177regulation of T-helper 2 cell differentiation (GO:0045628)2.56026354
178positive regulation of interferon-alpha production (GO:0032727)2.55024784
179regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.53658227
180negative regulation of granulocyte differentiation (GO:0030853)2.52166022
181positive regulation of receptor recycling (GO:0001921)2.50369987
182negative regulation of interleukin-6 production (GO:0032715)2.49805845
183regulation of B cell receptor signaling pathway (GO:0050855)2.49745944
184regulation of macrophage cytokine production (GO:0010935)2.47278623
185positive regulation of hemostasis (GO:1900048)2.44151765
186positive regulation of blood coagulation (GO:0030194)2.44151765
187B cell mediated immunity (GO:0019724)2.42940928
188negative regulation of cytokine production involved in immune response (GO:0002719)2.42673575
189negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41199961
190lipoxygenase pathway (GO:0019372)2.40810033
191regulation of platelet aggregation (GO:0090330)2.39032190
192regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.37602055
193regulation of tolerance induction (GO:0002643)2.37601222
194positive regulation of toll-like receptor signaling pathway (GO:0034123)2.37542371
195macrophage differentiation (GO:0030225)2.37082647
196myeloid leukocyte activation (GO:0002274)2.36576479
197regulation of gamma-delta T cell activation (GO:0046643)2.36248536
198positive regulation of coagulation (GO:0050820)2.35941313

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.69247819
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.67676785
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.35024634
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.00765946
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.76665070
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.77907255
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.76524279
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.75308867
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.61957170
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.34969259
11VDR_21846776_ChIP-Seq_THP-1_Human2.66947322
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.60504019
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37398988
14VDR_24763502_ChIP-Seq_THP-1_Human2.25945760
15* SPI1_23547873_ChIP-Seq_NB4_Human2.19623614
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06560791
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9341415
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95409276
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.93983864
20RUNX1_22412390_ChIP-Seq_EML_Mouse1.93234856
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.90437433
22SPI1_23127762_ChIP-Seq_K562_Human1.88503171
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88090982
24CLOCK_20551151_ChIP-Seq_293T_Human1.85805678
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81753068
26GATA1_22025678_ChIP-Seq_K562_Human1.70573115
27E2F7_22180533_ChIP-Seq_HELA_Human1.69660592
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69448330
29MYC_22102868_ChIP-Seq_BL_Human1.68656356
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65745222
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61445053
32TCF7_22412390_ChIP-Seq_EML_Mouse1.59184088
33MAF_26560356_Chip-Seq_TH1_Human1.58849873
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58201135
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57451726
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56928386
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56607314
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55892300
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53506113
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50945993
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49408804
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48043438
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46074919
44* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45316520
45* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43436084
46* FOXA2_19822575_ChIP-Seq_HepG2_Human1.43199140
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41785407
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39715865
49UTX_26944678_Chip-Seq_JUKART_Human1.39581186
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.33293520
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30062623
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.28287846
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24801253
54* HNF4A_19822575_ChIP-Seq_HepG2_Human1.24090002
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23973043
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23464735
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22621089
58MYB_26560356_Chip-Seq_TH1_Human1.22419868
59RACK7_27058665_Chip-Seq_MCF-7_Human1.22385657
60MYB_26560356_Chip-Seq_TH2_Human1.21804115
61* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19592842
62* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19532355
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18064444
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17834616
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17562787
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17562787
67KDM2B_26808549_Chip-Seq_DND41_Human1.16732937
68MAF_26560356_Chip-Seq_TH2_Human1.16375234
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16038819
70HTT_18923047_ChIP-ChIP_STHdh_Human1.15421683
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15365627
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.13158975
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12171425
74* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11825824
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10556449
76NCOR1_26117541_ChIP-Seq_K562_Human1.10518565
77ATF3_27146783_Chip-Seq_COLON_Human1.08761097
78TFEB_21752829_ChIP-Seq_HELA_Human1.07140016
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06807532
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06272225
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05110145
82* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05002587
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03560960
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03265711
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01783716
86RUNX_20019798_ChIP-Seq_JUKART_Human1.01723504
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01381772
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99409378
89* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98274595
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95685516
91SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91908478
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91170955
93GATA4_25053715_ChIP-Seq_YYC3_Human0.85120727
94SCL_19346495_ChIP-Seq_HPC-7_Human0.79978237
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79176322
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.78609867
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77457775
98* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.76460516
99LXR_22292898_ChIP-Seq_THP-1_Human0.74061119
100SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74029828
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73894448
102EGR1_19032775_ChIP-ChIP_M12_Human0.73644225
103GATA1_19941826_ChIP-Seq_K562_Human0.72277985
104GATA2_19941826_ChIP-Seq_K562_Human0.71633658
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71462594
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69409008
107ESR2_21235772_ChIP-Seq_MCF-7_Human0.67509693
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67297318
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.67267714
110* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66090029
111RARA_24833708_ChIP-Seq_LIVER_Mouse0.64886079
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63547625
113AUTS2_25519132_ChIP-Seq_293T-REX_Human0.63359162
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.63110564
115CEBPB_22108803_ChIP-Seq_LS180_Human0.62943121
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62435573
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62435573
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.62328734
119PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.61614097
120KAP1_22055183_ChIP-Seq_ESCs_Mouse0.61180709
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.60944774
122CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.60025199
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.59751364
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.59727361
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.59289112
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.58686324
127ZNF263_19887448_ChIP-Seq_K562_Human0.57990006
128GATA2_22383799_ChIP-Seq_G1ME_Mouse0.57962440
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.57381988
130RARB_24833708_ChIP-Seq_LIVER_Mouse0.57306670
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57001296
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.55213347
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.54430461
134CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.54341891
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.53971169
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.53612420
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.53152767
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.52917900
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.52767466
140AR_20517297_ChIP-Seq_VCAP_Human0.52346863
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.51819252
142PPAR_26484153_Chip-Seq_NCI-H1993_Human0.51806972
143* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.51490653
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.50846214
145SPI1_20517297_ChIP-Seq_HL60_Human0.49984288
146PU_27001747_Chip-Seq_BMDM_Mouse0.49416343
147BCOR_27268052_Chip-Seq_Bcells_Human0.49146141
148E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.48760187
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.48256344
150FOXA1_25552417_ChIP-Seq_VCAP_Human0.48248707
151ESR1_21235772_ChIP-Seq_MCF-7_Human0.47884657
152PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.47548501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.46086567
2MP0005360_urolithiasis6.80612750
3MP0005085_abnormal_gallbladder_physiolo5.69305873
4MP0005365_abnormal_bile_salt5.68141847
5MP0008875_abnormal_xenobiotic_pharmacok4.45133918
6MP0003806_abnormal_nucleotide_metabolis3.84979005
7MP0010329_abnormal_lipoprotein_level3.60222465
8MP0003252_abnormal_bile_duct3.44499539
9MP0009840_abnormal_foam_cell3.34648096
10MP0008260_abnormal_autophagy2.75311252
11MP0003191_abnormal_cellular_cholesterol2.74925680
12MP0005083_abnormal_biliary_tract2.72719568
13MP0005332_abnormal_amino_acid2.50359866
14MP0002877_abnormal_melanocyte_morpholog2.39240141
15MP0003195_calcinosis2.32867882
16MP0001666_abnormal_nutrient_absorption2.28118154
17MP0000609_abnormal_liver_physiology2.22657819
18MP0003828_pulmonary_edema2.21414634
19MP0000858_altered_metastatic_potential2.14764202
20MP0002118_abnormal_lipid_homeostasis2.13943015
21MP0003566_abnormal_cell_adhesion2.09630263
22MP0002138_abnormal_hepatobiliary_system1.99330765
23MP0004019_abnormal_vitamin_homeostasis1.90683587
24MP0005319_abnormal_enzyme/_coenzyme1.88721930
25MP0001764_abnormal_homeostasis1.78152330
26MP0003172_abnormal_lysosome_physiology1.67980068
27MP0002148_abnormal_hypersensitivity_rea1.62797327
28MP0005000_abnormal_immune_tolerance1.62403831
29MP0005584_abnormal_enzyme/coenzyme_acti1.60516911
30MP0003868_abnormal_feces_composition1.58728571
31MP0003436_decreased_susceptibility_to1.56673069
32MP0002723_abnormal_immune_serum1.52197225
33MP0002452_abnormal_antigen_presenting1.52067082
34MP0002420_abnormal_adaptive_immunity1.49413107
35MP0001819_abnormal_immune_cell1.48583564
36MP0003453_abnormal_keratinocyte_physiol1.48370680
37MP0003186_abnormal_redox_activity1.46238877
38MP0003656_abnormal_erythrocyte_physiolo1.45128390
39MP0003011_delayed_dark_adaptation1.42157430
40MP0001851_eye_inflammation1.42155494
41MP0000465_gastrointestinal_hemorrhage1.41080262
42MP0009697_abnormal_copulation1.37664551
43MP0005670_abnormal_white_adipose1.37167350
44MP0009764_decreased_sensitivity_to1.37015570
45MP0009278_abnormal_bone_marrow1.36845772
46MP0002405_respiratory_system_inflammati1.36210709
47MP0005387_immune_system_phenotype1.35233871
48MP0004381_abnormal_hair_follicle1.31865256
49MP0005451_abnormal_body_composition1.31610486
50MP0003705_abnormal_hypodermis_morpholog1.30568773
51MP0001545_abnormal_hematopoietic_system1.28878122
52MP0005397_hematopoietic_system_phenotyp1.28878122
53MP0009643_abnormal_urine_homeostasis1.23847721
54MP0000598_abnormal_liver_morphology1.23380414
55MP0000604_amyloidosis1.20898219
56MP0008469_abnormal_protein_level1.20343897
57MP0009763_increased_sensitivity_to1.19922591
58MP0005076_abnormal_cell_differentiation1.19893250
59MP0002396_abnormal_hematopoietic_system1.18891711
60MP0005375_adipose_tissue_phenotype1.17859968
61MP0003724_increased_susceptibility_to1.16300238
62MP0002254_reproductive_system_inflammat1.15212187
63MP0005464_abnormal_platelet_physiology1.14438197
64MP0002398_abnormal_bone_marrow1.13614654
65MP0001915_intracranial_hemorrhage1.11670067
66MP0000716_abnormal_immune_system1.09965876
67MP0002998_abnormal_bone_remodeling1.06819694
68MP0003448_altered_tumor_morphology1.06677826
69MP0002971_abnormal_brown_adipose1.06260190
70MP0002722_abnormal_immune_system1.05841931
71MP0004130_abnormal_muscle_cell1.05257745
72MP0005671_abnormal_response_to1.04204721
73MP0001849_ear_inflammation1.03911779
74MP0005647_abnormal_sex_gland1.02250659
75MP0002060_abnormal_skin_morphology1.01991070
76MP0005409_darkened_coat_color1.01239175
77MP0009333_abnormal_splenocyte_physiolog1.00666343
78MP0003183_abnormal_peptide_metabolism0.99803939
79MP0002429_abnormal_blood_cell0.99652423
80MP0010155_abnormal_intestine_physiology0.99629692
81MP0000689_abnormal_spleen_morphology0.97894838
82MP0010234_abnormal_vibrissa_follicle0.96612847
83MP0003091_abnormal_cell_migration0.95816907
84MP0002837_dystrophic_cardiac_calcinosis0.94443810
85MP0001853_heart_inflammation0.94179021
86MP0002796_impaired_skin_barrier0.93558690
87MP0005334_abnormal_fat_pad0.93453289
88MP0009642_abnormal_blood_homeostasis0.91945172
89MP0003303_peritoneal_inflammation0.90999518
90MP0002419_abnormal_innate_immunity0.90559152
91MP0009785_altered_susceptibility_to0.89640379
92MP0010352_gastrointestinal_tract_polyps0.87975387
93MP0001216_abnormal_epidermal_layer0.86976458
94MP0004808_abnormal_hematopoietic_stem0.86871591
95MP0005058_abnormal_lysosome_morphology0.85032212
96MP0006036_abnormal_mitochondrial_physio0.84244556
97MP0006054_spinal_hemorrhage0.83606927
98MP0005636_abnormal_mineral_homeostasis0.83452564
99MP0005376_homeostasis/metabolism_phenot0.83446644
100MP0003075_altered_response_to0.83238429
101MP0009765_abnormal_xenobiotic_induced0.82604540
102MP0010368_abnormal_lymphatic_system0.81132064
103MP0005535_abnormal_body_temperature0.80495653
104MP0005666_abnormal_adipose_tissue0.79804837
105MP0003690_abnormal_glial_cell0.79791189
106MP0002078_abnormal_glucose_homeostasis0.78187510
107MP0005390_skeleton_phenotype0.77876190
108MP0002876_abnormal_thyroid_physiology0.75377137
109MP0003763_abnormal_thymus_physiology0.75222607
110MP0005025_abnormal_response_to0.75140343
111MP0005408_hypopigmentation0.72694821
112MP0001845_abnormal_inflammatory_respons0.72145238
113MP0001533_abnormal_skeleton_physiology0.70211271
114MP0001835_abnormal_antigen_presentation0.68206743
115MP0004782_abnormal_surfactant_physiolog0.67575202
116MP0005084_abnormal_gallbladder_morpholo0.66908052
117MP0005448_abnormal_energy_balance0.66711111
118MP0001661_extended_life_span0.66385509
119MP0009115_abnormal_fat_cell0.64865120
120MP0001756_abnormal_urination0.62485233
121MP0006082_CNS_inflammation0.61868662
122MP0000685_abnormal_immune_system0.61349168
123MP0005166_decreased_susceptibility_to0.60904175
124MP0004883_abnormal_blood_vessel0.60594212
125MP0000343_altered_response_to0.59036726
126MP0003300_gastrointestinal_ulcer0.58762938
127MP0003638_abnormal_response/metabolism_0.58465208
128MP0005167_abnormal_blood-brain_barrier0.58203597
129MP0005220_abnormal_exocrine_pancreas0.57932993
130MP0005164_abnormal_response_to0.56802447
131MP0003329_amyloid_beta_deposits0.56405736
132MP0002970_abnormal_white_adipose0.54424306
133MP0000249_abnormal_blood_vessel0.54001292
134MP0002136_abnormal_kidney_physiology0.53759122
135MP0005266_abnormal_metabolism0.53644381
136MP0000639_abnormal_adrenal_gland0.52442693
137MP0009053_abnormal_anal_canal0.50864254
138MP0008873_increased_physiological_sensi0.49420020
139MP0002928_abnormal_bile_duct0.48672376
140MP0004947_skin_inflammation0.45906817
141MP0004185_abnormal_adipocyte_glucose0.45878297
142MP0001881_abnormal_mammary_gland0.45547006
143MP0008874_decreased_physiological_sensi0.43746268
144MP0005023_abnormal_wound_healing0.43287866
145MP0006035_abnormal_mitochondrial_morpho0.40676239
146MP0002132_abnormal_respiratory_system0.40449002
147MP0001800_abnormal_humoral_immune0.39988322
148MP0001790_abnormal_immune_system0.38899483

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.10740075
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.53001123
3Intrahepatic cholestasis (HP:0001406)6.50031585
4Prolonged partial thromboplastin time (HP:0003645)6.16295286
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.00347155
6Xanthomatosis (HP:0000991)5.96569474
7Hypobetalipoproteinemia (HP:0003563)5.67400840
8Complement deficiency (HP:0004431)5.49152816
9Hyperlipoproteinemia (HP:0010980)5.14170352
10Joint hemorrhage (HP:0005261)5.02193176
11Recurrent abscess formation (HP:0002722)4.85622993
12Abnormality of the common coagulation pathway (HP:0010990)4.54116831
13Hyperammonemia (HP:0001987)4.36979898
14Hypolipoproteinemia (HP:0010981)4.36768308
15Abnormality of macrophages (HP:0004311)4.31061833
16Epidermoid cyst (HP:0200040)4.22481775
17Abnormality of complement system (HP:0005339)4.17765291
18Recurrent gram-negative bacterial infections (HP:0005420)4.10294085
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.09236440
20Hyperglycinemia (HP:0002154)3.98856338
21Ketosis (HP:0001946)3.95060324
22Hypoalphalipoproteinemia (HP:0003233)3.91500568
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.90730321
24Myositis (HP:0100614)3.89129978
25Hyperglycinuria (HP:0003108)3.85365455
26Hypoglycemic coma (HP:0001325)3.81739305
27Fat malabsorption (HP:0002630)3.75909183
28Abnormality of glycine metabolism (HP:0010895)3.72615323
29Abnormality of serine family amino acid metabolism (HP:0010894)3.72615323
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.72211417
31Orchitis (HP:0100796)3.66654270
32Abnormality of methionine metabolism (HP:0010901)3.64351248
33Systemic lupus erythematosus (HP:0002725)3.61594321
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.57576094
35Hypercholesterolemia (HP:0003124)3.56833898
36Abnormality of pyrimidine metabolism (HP:0004353)3.56555045
37Abnormality of the intrinsic pathway (HP:0010989)3.52824208
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.51490460
39Abnormality of fatty-acid metabolism (HP:0004359)3.48863750
40Prolonged bleeding time (HP:0003010)3.47279327
41Gingivitis (HP:0000230)3.18904160
42Conjugated hyperbilirubinemia (HP:0002908)3.18726351
43Myocardial infarction (HP:0001658)3.16446388
44Hyperbilirubinemia (HP:0002904)3.12474035
45Chronic obstructive pulmonary disease (HP:0006510)3.12168579
46Obstructive lung disease (HP:0006536)3.12168579
47Purpura (HP:0000979)3.07627305
48Optic neuritis (HP:0100653)3.06635729
49Retrobulbar optic neuritis (HP:0100654)3.06635729
50Elevated erythrocyte sedimentation rate (HP:0003565)2.94423153
51Abnormality of liposaccharide metabolism (HP:0010968)2.92324780
52Abnormality of glycosphingolipid metabolism (HP:0004343)2.92324780
53Abnormality of glycolipid metabolism (HP:0010969)2.92324780
54Abnormality of nucleobase metabolism (HP:0010932)2.89512418
55Steatorrhea (HP:0002570)2.86882929
56Urticaria (HP:0001025)2.86762921
57Petechiae (HP:0000967)2.85051380
58Recurrent skin infections (HP:0001581)2.84745116
59Ketoacidosis (HP:0001993)2.80374425
60Glomerulonephritis (HP:0000099)2.80261079
61Peritonitis (HP:0002586)2.79313018
62Abnormality of serum amino acid levels (HP:0003112)2.74655827
63Hepatocellular carcinoma (HP:0001402)2.73369109
64Gastrointestinal infarctions (HP:0005244)2.73339847
65Spontaneous abortion (HP:0005268)2.69853310
66Delayed CNS myelination (HP:0002188)2.69625208
67Skin nodule (HP:0200036)2.68867134
68Gingival bleeding (HP:0000225)2.67008874
69Stomatitis (HP:0010280)2.66890384
70Spontaneous hematomas (HP:0007420)2.65577705
71Mediastinal lymphadenopathy (HP:0100721)2.64794550
72Keratoconjunctivitis sicca (HP:0001097)2.64075418
73Dicarboxylic aciduria (HP:0003215)2.60682444
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60682444
75Hypochromic microcytic anemia (HP:0004840)2.59636318
76Abnormality of purine metabolism (HP:0004352)2.55991105
77Menorrhagia (HP:0000132)2.54568939
78Amyloidosis (HP:0011034)2.53177014
79Acanthocytosis (HP:0001927)2.52617462
80Metabolic acidosis (HP:0001942)2.52035134
81Hepatosplenomegaly (HP:0001433)2.50421437
82Increased IgE level (HP:0003212)2.46763635
83Esophageal varix (HP:0002040)2.39809496
84Mitral stenosis (HP:0001718)2.37168843
85Vascular calcification (HP:0004934)2.35851461
86Recurrent fungal infections (HP:0002841)2.32817757
87Vertebral compression fractures (HP:0002953)2.32810554
88Spastic diplegia (HP:0001264)2.31975910
89Abnormal gallbladder morphology (HP:0012437)2.31752607
90Lethargy (HP:0001254)2.31682971
91Cellulitis (HP:0100658)2.30558629
92Keratoconjunctivitis (HP:0001096)2.29053552
93Episodic fever (HP:0001954)2.28910346
94Pustule (HP:0200039)2.28162223
95Cholelithiasis (HP:0001081)2.28029160
96Hypoglycemic seizures (HP:0002173)2.26518697
97Thick nail (HP:0001805)2.24416269
98Thrombophlebitis (HP:0004418)2.24261505
99Pancreatitis (HP:0001733)2.23540469
100Polycythemia (HP:0001901)2.22675153
101Increased cerebral lipofuscin (HP:0011813)2.22431140
102Cholecystitis (HP:0001082)2.21535095
103Abnormal gallbladder physiology (HP:0012438)2.21535095
104Dysostosis multiplex (HP:0000943)2.20958246
105Upper motor neuron abnormality (HP:0002127)2.18599930
106Periodontitis (HP:0000704)2.16047954
107Hemorrhage of the eye (HP:0011885)2.15907297
108Arterial thrombosis (HP:0004420)2.15607381
109Cheilitis (HP:0100825)2.13753091
110Meningitis (HP:0001287)2.13657326
111Hypertriglyceridemia (HP:0002155)2.13577645
112Irritability (HP:0000737)2.13107356
113Abnormality of iron homeostasis (HP:0011031)2.12409804
114Cardiovascular calcification (HP:0011915)2.10104614
115Polygenic inheritance (HP:0010982)2.08916013
116Nephritis (HP:0000123)2.08496672
117Abnormal platelet function (HP:0011869)2.08270729
118Impaired platelet aggregation (HP:0003540)2.08270729
119Increased serum ferritin (HP:0003281)2.07361108
120Cerebral edema (HP:0002181)2.07184172
121Neonatal onset (HP:0003623)2.07009538
122Generalized aminoaciduria (HP:0002909)2.05475518
123Sensorimotor neuropathy (HP:0007141)2.04204190
124Hydroxyprolinuria (HP:0003080)2.03276379
125Abnormality of proline metabolism (HP:0010907)2.03276379
126Anorexia (HP:0002039)2.03137783
127Eczematoid dermatitis (HP:0000976)2.02520675
128Vacuolated lymphocytes (HP:0001922)2.02132916
129Abnormality of transition element cation homeostasis (HP:0011030)2.01812820
130Loss of speech (HP:0002371)2.01578780
131Gastrointestinal inflammation (HP:0004386)2.01406122
132Late onset (HP:0003584)2.01092270
133Skin ulcer (HP:0200042)2.01036594
134Increased connective tissue (HP:0009025)1.99866579
135Abnormality of the peritoneum (HP:0002585)1.99758664
136Glomerulopathy (HP:0100820)1.99667932
137Poikilocytosis (HP:0004447)1.99245332
138Hypochromic anemia (HP:0001931)1.99231376
139Subacute progressive viral hepatitis (HP:0006572)1.98763853
140Axonal loss (HP:0003447)1.98017978
141Inflammation of the large intestine (HP:0002037)1.97773977
142Pulmonary embolism (HP:0002204)1.96499230
143Brushfield spots (HP:0001088)1.95806570
144Pathologic fracture (HP:0002756)1.95731439
145Gout (HP:0001997)1.95573772
146Vomiting (HP:0002013)1.93403594
147Malnutrition (HP:0004395)1.93213871
148Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93117811
149Encephalitis (HP:0002383)1.92142786
150Chest pain (HP:0100749)1.88832105
151Epistaxis (HP:0000421)1.88560467
152Bruising susceptibility (HP:0000978)1.88363534
153Interstitial pulmonary disease (HP:0006530)1.87538829
154Gangrene (HP:0100758)1.87300567
155Abnormal cartilage morphology (HP:0002763)1.87024334
156Milia (HP:0001056)1.86694944
157Nausea (HP:0002018)1.86558279
158Abnormality of the gallbladder (HP:0005264)1.84385500
159Abnormal enzyme/coenzyme activity (HP:0012379)1.84119135
160Increased mean platelet volume (HP:0011877)1.83759655
161Recurrent bacterial skin infections (HP:0005406)1.83437444
162Enlarged kidneys (HP:0000105)1.82066551
163Metaphyseal cupping (HP:0003021)1.82052203
164Elevated hepatic transaminases (HP:0002910)1.81284044
165Chronic mucocutaneous candidiasis (HP:0002728)1.81046267
166Recurrent cutaneous fungal infections (HP:0011370)1.81046267
167Increased neuronal autofluorescent lipopigment (HP:0002074)1.80816174
168Vasculitis (HP:0002633)1.80116747
169Toxemia of pregnancy (HP:0100603)1.78247773
170Opisthotonus (HP:0002179)1.78169818
171Abnormal platelet volume (HP:0011876)1.77462619
172Osteomyelitis (HP:0002754)1.76990184
173Abnormal blistering of the skin (HP:0008066)1.74226596
174Fatigue (HP:0012378)1.72803011
175Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70603235
176Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70603235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.67728032
2ERN14.59552762
3SIK13.83676923
4RIPK43.64622221
5FGFR43.49682449
6TAOK32.90361597
7TRIB32.88081313
8PKN22.68039498
9TYK22.20863949
10INSRR2.12007123
11CAMK1D2.11727716
12MST1R2.11108930
13PRPF4B1.94081949
14MAP2K31.92075311
15FLT31.90753768
16EPHB11.84748899
17ERBB41.70172089
18SMG11.70141922
19FGR1.70107121
20PIK3CG1.69133419
21KSR21.68964153
22PTK61.59058292
23BLK1.58157658
24MAPK111.56823893
25MAP3K21.53167902
26TBK11.50661635
27NME21.49732950
28IRAK41.47882419
29NEK91.47880698
30GRK61.45951802
31MAP2K41.37632422
32MAP3K141.37490942
33TAOK11.36913215
34JAK21.36392594
35CSK1.34670341
36KDR1.32556157
37PAK41.29615422
38MAP3K31.29573336
39IRAK31.29244096
40ABL21.27828856
41PRKAA21.26956171
42MAP4K11.25289083
43TGFBR21.24145157
44JAK11.22726783
45YES11.22289206
46CDK121.19624845
47RIPK11.16384154
48CAMK1G1.14628214
49FRK1.10686570
50DAPK21.08225392
51TESK21.07551447
52BTK1.04166771
53CSF1R1.01692020
54MAPK41.00574765
55EPHA20.99968823
56MAP3K110.98654391
57MOS0.97450124
58MAP3K100.90719371
59ICK0.89730752
60CDK60.87357632
61ZAP700.86661658
62MARK30.86595160
63FGFR30.84842832
64IKBKE0.84098254
65KIT0.83753917
66ARAF0.83220595
67TNK20.79930106
68FGFR20.79451779
69EPHA30.79306099
70RAF10.78481030
71MAP3K70.77453619
72MAP3K80.77371397
73PTK2B0.77206096
74LATS10.76798934
75IRAK20.75340193
76TEC0.74129681
77TIE10.71530313
78BMPR20.71320781
79PRKACG0.68091330
80IRAK10.67092787
81LRRK20.66657246
82MAP3K60.63430733
83LCK0.62598048
84PRKCZ0.61497923
85EIF2AK10.60620610
86MAP2K60.60618904
87PRKD20.60334939
88PDPK10.58305427
89SIK30.58218657
90JAK30.57396258
91HCK0.57077936
92STK100.56960805
93PTK20.56931952
94MAP3K130.55842325
95ERBB20.55109989
96MAPK120.54976404
97GSK3A0.53943623
98MET0.53569803
99KSR10.52734206
100STK380.51971164
101PRKAA10.50025731
102EEF2K0.49878200
103MARK20.49778160
104MAPKAPK20.49713821
105ITK0.49434117
106IGF1R0.49049555
107CDK40.47560576
108SGK30.47381059
109PINK10.46737196
110PDGFRB0.46545907
111PRKG20.46467146
112IKBKB0.46030793
113MAP3K50.45624052
114LYN0.45356446
115SYK0.45210535
116PDK10.44914032
117DYRK1B0.43857454
118RET0.43843188
119EGFR0.42690714
120TRPM70.42210560
121PDGFRA0.40595592
122PRKCQ0.39505981
123MYLK0.38256232
124FYN0.37984656
125FES0.36005940
126RPS6KA40.35617155
127ABL10.34975348
128PBK0.33829884
129PIM10.33755160
130BMX0.33655441
131MAP3K10.33331564
132TAOK20.33220218
133MATK0.31073851
134GRK10.30246609
135PRKCD0.28858312
136CHUK0.28445235
137MAP2K10.28115287
138TTN0.25726983

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.37153857
2Nitrogen metabolism_Homo sapiens_hsa009103.48308973
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29791328
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.08989982
5Complement and coagulation cascades_Homo sapiens_hsa046102.97282726
6Arginine biosynthesis_Homo sapiens_hsa002202.95206425
7Fatty acid degradation_Homo sapiens_hsa000712.60781282
8Tryptophan metabolism_Homo sapiens_hsa003802.59964157
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55985803
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54006687
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45210239
12Staphylococcus aureus infection_Homo sapiens_hsa051502.38905217
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36833691
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30410329
15Peroxisome_Homo sapiens_hsa041462.09909278
16Propanoate metabolism_Homo sapiens_hsa006402.08653303
17PPAR signaling pathway_Homo sapiens_hsa033202.06627486
18Caffeine metabolism_Homo sapiens_hsa002322.03181030
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03117427
20Histidine metabolism_Homo sapiens_hsa003401.96989033
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.95013699
22Fatty acid metabolism_Homo sapiens_hsa012121.94781625
23Butanoate metabolism_Homo sapiens_hsa006501.93705216
24Chemical carcinogenesis_Homo sapiens_hsa052041.84682816
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82627816
26Acute myeloid leukemia_Homo sapiens_hsa052211.81117014
27beta-Alanine metabolism_Homo sapiens_hsa004101.77115231
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.75903107
29Tuberculosis_Homo sapiens_hsa051521.75855033
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.71094774
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70365675
32Retinol metabolism_Homo sapiens_hsa008301.63140907
33B cell receptor signaling pathway_Homo sapiens_hsa046621.60935290
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58918404
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58775256
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53889828
37Chronic myeloid leukemia_Homo sapiens_hsa052201.53393561
38Phenylalanine metabolism_Homo sapiens_hsa003601.53377343
39Pancreatic cancer_Homo sapiens_hsa052121.53370855
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50159254
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49154062
42Selenocompound metabolism_Homo sapiens_hsa004501.48045397
43Pyruvate metabolism_Homo sapiens_hsa006201.41569230
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40504423
45Non-small cell lung cancer_Homo sapiens_hsa052231.39111443
46Tyrosine metabolism_Homo sapiens_hsa003501.38231188
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.35516324
48Toxoplasmosis_Homo sapiens_hsa051451.35433038
49Bile secretion_Homo sapiens_hsa049761.32662899
50Shigellosis_Homo sapiens_hsa051311.32654062
51Phagosome_Homo sapiens_hsa041451.32259928
52Platelet activation_Homo sapiens_hsa046111.31015939
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30475443
54Hematopoietic cell lineage_Homo sapiens_hsa046401.30450491
55Fatty acid elongation_Homo sapiens_hsa000621.29104011
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28551295
57ABC transporters_Homo sapiens_hsa020101.26233693
58Carbon metabolism_Homo sapiens_hsa012001.25413935
59* Starch and sucrose metabolism_Homo sapiens_hsa005001.24178124
60Salmonella infection_Homo sapiens_hsa051321.23472411
61Sulfur metabolism_Homo sapiens_hsa009201.23266874
62Measles_Homo sapiens_hsa051621.23160909
63Fat digestion and absorption_Homo sapiens_hsa049751.19940095
64Biosynthesis of amino acids_Homo sapiens_hsa012301.18977690
65Influenza A_Homo sapiens_hsa051641.13987978
66Chemokine signaling pathway_Homo sapiens_hsa040621.13184081
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.12043356
68Folate biosynthesis_Homo sapiens_hsa007901.09775458
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09075140
70NF-kappa B signaling pathway_Homo sapiens_hsa040641.05602775
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04632305
72Apoptosis_Homo sapiens_hsa042101.03951414
73TNF signaling pathway_Homo sapiens_hsa046681.02058621
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01992134
75Steroid biosynthesis_Homo sapiens_hsa001001.00882421
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96780779
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96500101
78Hepatitis B_Homo sapiens_hsa051610.94083704
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.91493618
80Sulfur relay system_Homo sapiens_hsa041220.91164380
81Renal cell carcinoma_Homo sapiens_hsa052110.89816703
82VEGF signaling pathway_Homo sapiens_hsa043700.88376188
83Small cell lung cancer_Homo sapiens_hsa052220.87626457
84Pentose phosphate pathway_Homo sapiens_hsa000300.85641165
85Herpes simplex infection_Homo sapiens_hsa051680.84607924
86Thyroid cancer_Homo sapiens_hsa052160.84110187
87Glycerolipid metabolism_Homo sapiens_hsa005610.82731211
88Fatty acid biosynthesis_Homo sapiens_hsa000610.82023702
89Arginine and proline metabolism_Homo sapiens_hsa003300.81798057
90Bladder cancer_Homo sapiens_hsa052190.81441867
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81428195
92Vitamin B6 metabolism_Homo sapiens_hsa007500.81297111
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.80217384
94Lysine degradation_Homo sapiens_hsa003100.79766071
95Vitamin digestion and absorption_Homo sapiens_hsa049770.78726761
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78722068
97Endocytosis_Homo sapiens_hsa041440.78243480
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.77396898
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76018904
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72115389
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71232807
102Glutathione metabolism_Homo sapiens_hsa004800.70776915
103T cell receptor signaling pathway_Homo sapiens_hsa046600.68709592
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68069202
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67479291
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67054378
107HIF-1 signaling pathway_Homo sapiens_hsa040660.66778230
108Proteoglycans in cancer_Homo sapiens_hsa052050.66460010
109Focal adhesion_Homo sapiens_hsa045100.65950381
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.65554384
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.64432666
112Notch signaling pathway_Homo sapiens_hsa043300.64296438
113Viral carcinogenesis_Homo sapiens_hsa052030.61374733
114One carbon pool by folate_Homo sapiens_hsa006700.61201470
115Antigen processing and presentation_Homo sapiens_hsa046120.60424611
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.59182381
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55645276
118Viral myocarditis_Homo sapiens_hsa054160.51412286
119Endometrial cancer_Homo sapiens_hsa052130.50785532
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49587788
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47263306
122Prolactin signaling pathway_Homo sapiens_hsa049170.47236580
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46072629
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45409563
125FoxO signaling pathway_Homo sapiens_hsa040680.45014442
126Adherens junction_Homo sapiens_hsa045200.43808139
127* Metabolic pathways_Homo sapiens_hsa011000.40393052
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.39386092
129Glioma_Homo sapiens_hsa052140.38217332
130Galactose metabolism_Homo sapiens_hsa000520.35115874
131Prion diseases_Homo sapiens_hsa050200.34377567
132* Insulin resistance_Homo sapiens_hsa049310.32292189
133Fructose and mannose metabolism_Homo sapiens_hsa000510.30686612
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16223095
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.15331960
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.14836660
137Linoleic acid metabolism_Homo sapiens_hsa005910.13440125
138AMPK signaling pathway_Homo sapiens_hsa041520.11870780
139Pertussis_Homo sapiens_hsa051330.08563295
140Leishmaniasis_Homo sapiens_hsa051400.06022323
141* Glucagon signaling pathway_Homo sapiens_hsa049220.01528305
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1482428
143Renin-angiotensin system_Homo sapiens_hsa04614-0.1254573
144Osteoclast differentiation_Homo sapiens_hsa04380-0.1231295
145Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.1112339
146Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1063993
147African trypanosomiasis_Homo sapiens_hsa05143-0.0993830
148Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0759889
149Hepatitis C_Homo sapiens_hsa05160-0.0679277
150Malaria_Homo sapiens_hsa05144-0.0673883
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0613266
152Amoebiasis_Homo sapiens_hsa05146-0.0537130
153Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0491616
154Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0474567
155* Insulin signaling pathway_Homo sapiens_hsa04910-0.0460089
156Other glycan degradation_Homo sapiens_hsa00511-0.0311883
157Legionellosis_Homo sapiens_hsa05134-0.0279749
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0279202
159Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0187411
160Lysosome_Homo sapiens_hsa04142-0.0180956

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