PYGM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)9.76438498
2muscle filament sliding (GO:0030049)9.76438498
3regulation of skeletal muscle contraction (GO:0014819)8.96601478
4sarcomere organization (GO:0045214)8.66260774
5actin-mediated cell contraction (GO:0070252)8.03113520
6sarcoplasmic reticulum calcium ion transport (GO:0070296)7.48422068
7myofibril assembly (GO:0030239)7.47867434
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.23776856
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.99295159
10cardiac myofibril assembly (GO:0055003)6.98750695
11plasma membrane repair (GO:0001778)6.93230092
12skeletal muscle contraction (GO:0003009)6.78878264
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.69046471
14striated muscle contraction (GO:0006941)6.24519754
15negative regulation of potassium ion transmembrane transport (GO:1901380)6.22332056
16cardiac muscle contraction (GO:0060048)6.12185956
17actin filament-based movement (GO:0030048)6.00220493
18skeletal muscle adaptation (GO:0043501)5.77832601
19carnitine shuttle (GO:0006853)5.73234565
20tricarboxylic acid cycle (GO:0006099)5.68462612
21regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.66856633
22actomyosin structure organization (GO:0031032)5.64134017
23regulation of relaxation of muscle (GO:1901077)5.63068090
24regulation of cell communication by electrical coupling (GO:0010649)5.56318581
25response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.42610152
26regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.41399506
27regulation of actin filament-based movement (GO:1903115)5.41091850
28regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.39428999
29regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.38126992
30cardiac muscle cell development (GO:0055013)5.28030580
31creatine metabolic process (GO:0006600)5.14225868
32cardiac cell development (GO:0055006)4.95048077
33regulation of acyl-CoA biosynthetic process (GO:0050812)4.91553266
34skeletal muscle tissue development (GO:0007519)4.90912812
35fatty acid transmembrane transport (GO:1902001)4.88307303
36regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.75821056
37regulation of striated muscle contraction (GO:0006942)4.66768184
38muscle contraction (GO:0006936)4.58277624
39response to inactivity (GO:0014854)4.54271088
40cardiac muscle tissue morphogenesis (GO:0055008)4.53654188
41cardiac muscle hypertrophy (GO:0003300)4.53065843
42ventricular cardiac muscle cell action potential (GO:0086005)4.51887688
43adult heart development (GO:0007512)4.51808368
44regulation of coenzyme metabolic process (GO:0051196)4.50099637
45regulation of cofactor metabolic process (GO:0051193)4.50099637
46striated muscle hypertrophy (GO:0014897)4.46111271
47heart contraction (GO:0060047)4.38993087
48heart process (GO:0003015)4.38993087
49regulation of sarcomere organization (GO:0060297)4.38548413
50regulation of membrane repolarization (GO:0060306)4.37559001
51response to muscle activity (GO:0014850)4.26929901
52striated muscle adaptation (GO:0014888)4.26303119
53muscle tissue morphogenesis (GO:0060415)4.25608577
54carnitine transmembrane transport (GO:1902603)4.23556278
55muscle system process (GO:0003012)4.20799193
56fructose metabolic process (GO:0006000)4.17323294
57striated muscle atrophy (GO:0014891)4.10202966
58pyrimidine ribonucleoside catabolic process (GO:0046133)4.09430977
59* glucan catabolic process (GO:0009251)4.07470172
60muscle cell fate commitment (GO:0042693)4.02571510
61muscle organ morphogenesis (GO:0048644)4.01933730
62muscle structure development (GO:0061061)4.01410012
63muscle organ development (GO:0007517)4.00603727
64response to activity (GO:0014823)3.99646103
65positive regulation of myotube differentiation (GO:0010831)3.97709095
66positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.96815007
67heart trabecula formation (GO:0060347)3.93596779
68muscle hypertrophy (GO:0014896)3.92670829
69gluconeogenesis (GO:0006094)3.85709090
70bundle of His cell to Purkinje myocyte communication (GO:0086069)3.85435217
71striated muscle cell development (GO:0055002)3.84765571
72amino-acid betaine transport (GO:0015838)3.84740988
73carnitine transport (GO:0015879)3.84740988
74regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.84196832
75muscle fiber development (GO:0048747)3.82504106
76ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.82268251
77* cellular polysaccharide catabolic process (GO:0044247)3.80408956
78cytidine metabolic process (GO:0046087)3.77738259
79cytidine catabolic process (GO:0006216)3.77738259
80cytidine deamination (GO:0009972)3.77738259
81skeletal muscle fiber development (GO:0048741)3.75764068
82regulation of calcium ion transmembrane transporter activity (GO:1901019)3.74498382
83regulation of calcium ion transmembrane transport (GO:1903169)3.74498382
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.73742721
85NADH metabolic process (GO:0006734)3.69796484
86skeletal muscle tissue regeneration (GO:0043403)3.67003928
87* glycogen metabolic process (GO:0005977)3.66917747
88positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.64968606
89negative regulation of calcium ion transmembrane transport (GO:1903170)3.63253326
90negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.63253326
91myoblast fusion (GO:0007520)3.61985718
92regulation of sulfur metabolic process (GO:0042762)3.61886903
932-oxoglutarate metabolic process (GO:0006103)3.61845826
94cell communication involved in cardiac conduction (GO:0086065)3.60641179
95glucan biosynthetic process (GO:0009250)3.60471933
96glycogen biosynthetic process (GO:0005978)3.60471933
97* cellular glucan metabolic process (GO:0006073)3.59570410
98* glucan metabolic process (GO:0044042)3.59570410
99neuronal action potential propagation (GO:0019227)3.59274827
100negative regulation of muscle contraction (GO:0045932)3.52419664
101muscle adaptation (GO:0043500)3.51802439
102muscle atrophy (GO:0014889)3.49400609
103regulation of skeletal muscle cell differentiation (GO:2001014)3.49255635
104cardiac muscle cell action potential (GO:0086001)3.48896922
105cardiac muscle cell action potential involved in contraction (GO:0086002)3.48611019
106cardiac muscle adaptation (GO:0014887)3.48586371
107cardiac muscle hypertrophy in response to stress (GO:0014898)3.48586371
108muscle hypertrophy in response to stress (GO:0003299)3.48586371
109regulation of the force of heart contraction (GO:0002026)3.48307260
110negative regulation of potassium ion transport (GO:0043267)3.47036046
111positive regulation of cation channel activity (GO:2001259)3.46671118
112IMP metabolic process (GO:0046040)3.46188344
113negative regulation of protein localization to cell surface (GO:2000009)3.45880121
114hexose biosynthetic process (GO:0019319)3.44048574
115myotube differentiation (GO:0014902)3.43871015
116* polysaccharide catabolic process (GO:0000272)3.40134882
117negative regulation of muscle hypertrophy (GO:0014741)3.37271819
118regulation of sequestering of triglyceride (GO:0010889)3.36404107
119oxidative phosphorylation (GO:0006119)3.35915771
120ubiquinone biosynthetic process (GO:0006744)3.35666451
121striated muscle tissue development (GO:0014706)3.35631436
122relaxation of muscle (GO:0090075)3.35619996
123muscle cell cellular homeostasis (GO:0046716)3.34782795
124regulation of myoblast differentiation (GO:0045661)3.34464524
125regulation of ATP catabolic process (GO:1903289)3.32929421
126regulation of ATPase activity (GO:0043462)3.32929421
127regulation of muscle contraction (GO:0006937)3.31448058
128* glycogen catabolic process (GO:0005980)3.30300511
129muscle cell development (GO:0055001)3.28780450
130myotube cell development (GO:0014904)3.26577595
131neuromuscular synaptic transmission (GO:0007274)3.23198460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.78473575
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.62509822
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.69861564
4EP300_21415370_ChIP-Seq_HL-1_Mouse3.59532329
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.53494713
6TBX20_22328084_ChIP-Seq_HEART_Mouse3.51837481
7TBX20_22080862_ChIP-Seq_HEART_Mouse3.51837481
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.28561853
9ZNF263_19887448_ChIP-Seq_K562_Human2.89935461
10MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.56251138
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53430289
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.33122502
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28971067
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.22871188
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20561978
16EZH2_22144423_ChIP-Seq_EOC_Human2.17860208
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16568945
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.12802986
19GATA4_21415370_ChIP-Seq_HL-1_Mouse1.84359987
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.75960251
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.71443438
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.68498113
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.66070061
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62441812
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56238199
26DROSHA_22980978_ChIP-Seq_HELA_Human1.55962247
27CLOCK_20551151_ChIP-Seq_293T_Human1.52148275
28CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.49967100
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.49242383
30* CTCF_27219007_Chip-Seq_Bcells_Human1.47181998
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47153059
32NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.43043351
33* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37082835
34IGF1R_20145208_ChIP-Seq_DFB_Human1.36781343
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35099735
36NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30320430
37KDM2B_26808549_Chip-Seq_DND41_Human1.30286786
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30178662
39* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30083237
40* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26930584
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24069398
42LXR_22292898_ChIP-Seq_THP-1_Human1.22363460
43PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21799556
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18780202
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18765609
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15612174
47CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15522850
48P68_20966046_ChIP-Seq_HELA_Human1.14266742
49* TP63_22573176_ChIP-Seq_HFKS_Human1.13851745
50ZNF274_21170338_ChIP-Seq_K562_Hela1.10904609
51CRX_20693478_ChIP-Seq_RETINA_Mouse1.10567841
52SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10503439
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09648477
54FOXH1_21741376_ChIP-Seq_ESCs_Human1.08613127
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08492101
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07603608
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.06720875
58STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.06578618
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.06082365
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06043720
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05880405
62GBX2_23144817_ChIP-Seq_PC3_Human1.05459150
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05135967
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05075819
65AR_21572438_ChIP-Seq_LNCaP_Human1.04928100
66RACK7_27058665_Chip-Seq_MCF-7_Human1.04861591
67OCT4_20526341_ChIP-Seq_ESCs_Human1.04462125
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.03613233
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03602556
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.03311513
71* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03178565
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02972852
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.02069980
74SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00616343
75OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99569652
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99548454
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97465664
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97425049
79YY1_22570637_ChIP-Seq_MALME-3M_Human0.96597604
80MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94276541
81CTCF_21964334_Chip-Seq_Bcells_Human0.94206391
82SA1_27219007_Chip-Seq_Bcells_Human0.93713360
83HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93690273
84P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93293729
85BCL6_27268052_Chip-Seq_Bcells_Human0.93183438
86PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92377692
87GATA1_19941826_ChIP-Seq_K562_Human0.92098235
88SPI1_20517297_ChIP-Seq_HL60_Human0.91046814
89RUNX1_27514584_Chip-Seq_MCF-7_Human0.90802462
90* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90437169
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.89988695
92SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89952491
93KDM2B_26808549_Chip-Seq_K562_Human0.88950706
94ATF3_27146783_Chip-Seq_COLON_Human0.88944027
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88454763
96SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88358762
97LXR_22158963_ChIP-Seq_LIVER_Mouse0.88320596
98RXR_22158963_ChIP-Seq_LIVER_Mouse0.88310942
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87747571
100CREB1_26743006_Chip-Seq_LNCaP_Human0.87300246
101TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86948008
102RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86514549
103EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86514549
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86280522
105SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86041848
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85893230
107SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.85772513
108E2F1_20622854_ChIP-Seq_HELA_Human0.85545673
109ER_23166858_ChIP-Seq_MCF-7_Human0.85432607
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.85239363
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84619891
112RARB_27405468_Chip-Seq_BRAIN_Mouse0.84388508
113SMC4_20622854_ChIP-Seq_HELA_Human0.83991226
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.83935259
115CJUN_26792858_Chip-Seq_BT549_Human0.82276191
116* SOX2_21211035_ChIP-Seq_LN229_Gbm0.80996041
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80676140
118EZH2_27304074_Chip-Seq_ESCs_Mouse0.80662525
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80352578
120GATA1_22025678_ChIP-Seq_K562_Human0.80326295
121KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80215389
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79990894
123GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79424986
124PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79315692
125GATA6_21074721_ChIP-Seq_CACO-2_Human0.79048571
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78902430
127MYC_27129775_Chip-Seq_CORNEA_Mouse0.78774825
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77240726
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77240726
130VDR_22108803_ChIP-Seq_LS180_Human0.76890611
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76559380
132HTT_18923047_ChIP-ChIP_STHdh_Human0.75708586
133EGR1_19032775_ChIP-ChIP_M12_Human0.74369648
134GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.74346072
135CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.73068549
136LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.72944611
137NANOG_20526341_ChIP-Seq_ESCs_Human0.72635236
138NANOG_19829295_ChIP-Seq_ESCs_Human0.72520566
139SOX2_19829295_ChIP-Seq_ESCs_Human0.72520566
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71602426
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.71165906
142* STAT1_20625510_ChIP-Seq_HELA_Human0.71096322
143RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70134851
144SMAD3_21741376_ChIP-Seq_HESCs_Human0.69181411
145* DPY_21335234_ChIP-Seq_ESCs_Mouse0.68809906
146JARID2_20075857_ChIP-Seq_MESCs_Mouse0.68690431
147CBP_20019798_ChIP-Seq_JUKART_Human0.68537015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.32247828
2MP0002837_dystrophic_cardiac_calcinosis5.88330357
3MP0000751_myopathy5.71522639
4MP0000749_muscle_degeneration5.15317857
5MP0004145_abnormal_muscle_electrophysio4.70729625
6MP0004036_abnormal_muscle_relaxation4.48979459
7MP0004084_abnormal_cardiac_muscle4.47221532
8MP0004215_abnormal_myocardial_fiber3.71449546
9MP0004087_abnormal_muscle_fiber3.39079525
10MP0002106_abnormal_muscle_physiology3.38276663
11MP0005330_cardiomyopathy3.25901966
12MP0000747_muscle_weakness3.16196729
13MP0000750_abnormal_muscle_regeneration3.11380465
14MP0005620_abnormal_muscle_contractility3.06071227
15MP0004130_abnormal_muscle_cell2.97941009
16MP0002269_muscular_atrophy2.92265640
17MP0000759_abnormal_skeletal_muscle2.85723609
18MP0005369_muscle_phenotype2.79022484
19MP0002972_abnormal_cardiac_muscle2.55593445
20MP0004233_abnormal_muscle_weight2.29541633
21MP0003137_abnormal_impulse_conducting2.22263459
22MP0008775_abnormal_heart_ventricle2.19592055
23MP0010630_abnormal_cardiac_muscle2.16046637
24MP0004484_altered_response_of2.07469065
25MP0005385_cardiovascular_system_phenoty2.04194770
26MP0001544_abnormal_cardiovascular_syste2.04194770
27MP0002332_abnormal_exercise_endurance1.88617960
28MP0006036_abnormal_mitochondrial_physio1.84219838
29MP0006138_congestive_heart_failure1.70304018
30MP0003221_abnormal_cardiomyocyte_apopto1.68142092
31MP0005666_abnormal_adipose_tissue1.51478604
32MP0004085_abnormal_heartbeat1.51364744
33MP0003950_abnormal_plasma_membrane1.48611818
34MP0003828_pulmonary_edema1.45360020
35MP0002108_abnormal_muscle_morphology1.43615541
36MP0000733_abnormal_muscle_development1.34653864
37MP0004510_myositis1.33812222
38MP0004185_abnormal_adipocyte_glucose1.30210962
39MP0002127_abnormal_cardiovascular_syste1.26754681
40MP0002234_abnormal_pharynx_morphology1.17564486
41MP0005670_abnormal_white_adipose1.12986193
42MP0005375_adipose_tissue_phenotype1.07238591
43MP0001661_extended_life_span1.06818547
44MP0006035_abnormal_mitochondrial_morpho1.02761817
45MP0000343_altered_response_to0.96389986
46MP0000266_abnormal_heart_morphology0.93287560
47MP0005266_abnormal_metabolism0.93251611
48MP0002971_abnormal_brown_adipose0.90902304
49MP0003705_abnormal_hypodermis_morpholog0.83458797
50MP0003567_abnormal_fetal_cardiomyocyte0.83088380
51MP0005275_abnormal_skin_tensile0.81556229
52MP0000013_abnormal_adipose_tissue0.78985709
53MP0000372_irregular_coat_pigmentation0.75724717
54MP0003806_abnormal_nucleotide_metabolis0.72220910
55MP0005165_increased_susceptibility_to0.71422828
56MP0004043_abnormal_pH_regulation0.66400942
57MP0000230_abnormal_systemic_arterial0.65560504
58MP0003279_aneurysm0.65406362
59MP0003879_abnormal_hair_cell0.63361090
60MP0000003_abnormal_adipose_tissue0.62235589
61MP0010368_abnormal_lymphatic_system0.60183109
62MP0004147_increased_porphyrin_level0.59367043
63MP0002128_abnormal_blood_circulation0.58097760
64MP0004134_abnormal_chest_morphology0.57603921
65MP0008961_abnormal_basal_metabolism0.55238861
66MP0002909_abnormal_adrenal_gland0.52892586
67MP0002078_abnormal_glucose_homeostasis0.52645403
68MP0004142_abnormal_muscle_tone0.50395307
69MP0002638_abnormal_pupillary_reflex0.45456871
70MP0001879_abnormal_lymphatic_vessel0.44790294
71MP0003566_abnormal_cell_adhesion0.42424530
72MP0004270_analgesia0.41857177
73MP0005623_abnormal_meninges_morphology0.41202265
74MP0008569_lethality_at_weaning0.41011820
75MP0005334_abnormal_fat_pad0.40936847
76MP0005319_abnormal_enzyme/_coenzyme0.40356716
77MP0005423_abnormal_somatic_nervous0.38642411
78MP0002734_abnormal_mechanical_nocicepti0.38332167
79MP0009672_abnormal_birth_weight0.38299021
80MP0001346_abnormal_lacrimal_gland0.37322785
81MP0005451_abnormal_body_composition0.36281913
82MP0010030_abnormal_orbit_morphology0.34433406
83MP0005166_decreased_susceptibility_to0.34134912
84MP0005187_abnormal_penis_morphology0.34119953
85MP0003045_fibrosis0.33662356
86MP0003656_abnormal_erythrocyte_physiolo0.33172256
87MP0002114_abnormal_axial_skeleton0.33159787
88MP0003948_abnormal_gas_homeostasis0.33027976
89MP0008438_abnormal_cutaneous_collagen0.32846623
90MP0005535_abnormal_body_temperature0.32157959
91MP0000767_abnormal_smooth_muscle0.32136303
92MP0000579_abnormal_nail_morphology0.31304766
93MP0001299_abnormal_eye_distance/0.31152650
94MP0002925_abnormal_cardiovascular_devel0.29991059
95MP0005584_abnormal_enzyme/coenzyme_acti0.29734694
96MP0009115_abnormal_fat_cell0.28114671
97MP0005452_abnormal_adipose_tissue0.28052952
98MP0000762_abnormal_tongue_morphology0.27860945
99MP0005332_abnormal_amino_acid0.27302073
100MP0009250_abnormal_appendicular_skeleto0.26830682
101MP0009780_abnormal_chondrocyte_physiolo0.26378824
102MP0001784_abnormal_fluid_regulation0.25249920
103MP0006276_abnormal_autonomic_nervous0.24970370
104MP0002090_abnormal_vision0.24953753
105MP0002822_catalepsy0.24371850
106MP0002896_abnormal_bone_mineralization0.24039587
107MP0002066_abnormal_motor_capabilities/c0.23543133
108MP0001614_abnormal_blood_vessel0.23339931
109MP0001943_abnormal_respiration0.22491320
110MP0004272_abnormal_basement_membrane0.22205265
111MP0002118_abnormal_lipid_homeostasis0.21100160
112MP0002876_abnormal_thyroid_physiology0.20323722
113MP0002067_abnormal_sensory_capabilities0.18653981
114MP0009384_cardiac_valve_regurgitation0.18207566
115MP0001853_heart_inflammation0.18097022
116MP0005645_abnormal_hypothalamus_physiol0.17866945
117MP0005376_homeostasis/metabolism_phenot0.17828119
118MP0003959_abnormal_lean_body0.17668431
119MP0005595_abnormal_vascular_smooth0.17164839
120MP0005386_behavior/neurological_phenoty0.17064123
121MP0004924_abnormal_behavior0.17064123
122MP0005167_abnormal_blood-brain_barrier0.17057670
123MP0005503_abnormal_tendon_morphology0.16971633
124MP0005083_abnormal_biliary_tract0.16237482
125MP0004858_abnormal_nervous_system0.12065673
126MP0008874_decreased_physiological_sensi0.11742980

Predicted human phenotypes

RankGene SetZ-score
1* Exercise-induced myalgia (HP:0003738)7.14586218
2Muscle hypertrophy of the lower extremities (HP:0008968)7.03570382
3Calf muscle hypertrophy (HP:0008981)6.95509817
4Muscle fiber inclusion bodies (HP:0100299)6.73651459
5* Exercise-induced muscle cramps (HP:0003710)6.60204126
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.54233412
7Muscle fiber splitting (HP:0003555)6.13544374
8Sudden death (HP:0001699)6.09919492
9Nemaline bodies (HP:0003798)5.85651098
10Type 1 muscle fiber predominance (HP:0003803)5.52518232
11Hyporeflexia of lower limbs (HP:0002600)5.46340188
12Abnormality of the calf musculature (HP:0001430)5.28211492
13Difficulty running (HP:0009046)5.05961942
14* Myoglobinuria (HP:0002913)5.04303325
15Ventricular tachycardia (HP:0004756)4.90562967
16EMG: myopathic abnormalities (HP:0003458)4.89731273
17Abnormality of the left ventricular outflow tract (HP:0011103)4.80182992
18Subaortic stenosis (HP:0001682)4.80182992
19Distal arthrogryposis (HP:0005684)4.79283864
20Increased connective tissue (HP:0009025)4.71590877
21Myopathic facies (HP:0002058)4.34040812
22Myotonia (HP:0002486)4.24307674
23Round ear (HP:0100830)4.21461998
24Muscle stiffness (HP:0003552)4.03336372
25Atrial fibrillation (HP:0005110)3.93375189
26Lipoatrophy (HP:0100578)3.84567326
27Asymmetric septal hypertrophy (HP:0001670)3.81894047
28* Rhabdomyolysis (HP:0003201)3.81261705
29Ulnar deviation of the wrist (HP:0003049)3.75673914
30Primary atrial arrhythmia (HP:0001692)3.66719405
31Abnormality of skeletal muscle fiber size (HP:0012084)3.54180495
32Supraventricular tachycardia (HP:0004755)3.54012760
33Difficulty climbing stairs (HP:0003551)3.52464842
34Right ventricular cardiomyopathy (HP:0011663)3.48200193
35Supraventricular arrhythmia (HP:0005115)3.46595763
36Increased variability in muscle fiber diameter (HP:0003557)3.42835574
37Dilated cardiomyopathy (HP:0001644)3.35668152
38Neck muscle weakness (HP:0000467)3.30301107
39Bundle branch block (HP:0011710)3.27098704
40Palpitations (HP:0001962)3.13741331
41Rimmed vacuoles (HP:0003805)3.08824336
42Calcaneovalgus deformity (HP:0001848)3.08700011
43Prolonged QT interval (HP:0001657)3.07383211
44Syncope (HP:0001279)3.06357374
45Areflexia of lower limbs (HP:0002522)3.04736333
46Ventricular arrhythmia (HP:0004308)2.91826544
47Absent phalangeal crease (HP:0006109)2.87323116
48Deformed tarsal bones (HP:0008119)2.86992640
49Distal lower limb muscle weakness (HP:0009053)2.78282125
50Heart block (HP:0012722)2.77038694
51Fetal akinesia sequence (HP:0001989)2.65822021
52Slender build (HP:0001533)2.61869990
53Abnormal atrioventricular conduction (HP:0005150)2.61673587
54Frequent falls (HP:0002359)2.61438935
55Ventricular fibrillation (HP:0001663)2.56459121
56Limb-girdle muscle atrophy (HP:0003797)2.54134054
57Atrioventricular block (HP:0001678)2.52626691
58EMG: neuropathic changes (HP:0003445)2.46484531
59Mildly elevated creatine phosphokinase (HP:0008180)2.43179150
60Muscular dystrophy (HP:0003560)2.41451656
61Abnormality of the calcaneus (HP:0008364)2.41386730
62Abnormal finger flexion creases (HP:0006143)2.35093341
63Hypoplastic ischia (HP:0003175)2.34452273
64Malignant hyperthermia (HP:0002047)2.31956711
65Generalized muscle weakness (HP:0003324)2.31165543
66Abnormal EKG (HP:0003115)2.25341276
67Gowers sign (HP:0003391)2.23929901
68Left ventricular hypertrophy (HP:0001712)2.23574684
69Facial diplegia (HP:0001349)2.22426107
70Hip contracture (HP:0003273)2.21458151
71Scapular winging (HP:0003691)2.17095672
72Distal lower limb amyotrophy (HP:0008944)2.16359376
73Hyperkalemia (HP:0002153)2.13838345
74Centrally nucleated skeletal muscle fibers (HP:0003687)2.13756457
75Proximal amyotrophy (HP:0007126)2.11464785
76Waddling gait (HP:0002515)2.10807210
77Abnormality of the neuromuscular junction (HP:0003398)2.10054475
78Fatigable weakness (HP:0003473)2.10054475
79Limb-girdle muscle weakness (HP:0003325)2.06608487
80Abnormality of the ischium (HP:0003174)2.03254852
81Lower limb amyotrophy (HP:0007210)2.00064819
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.99717412
83Ketoacidosis (HP:0001993)1.98320247
84Abnormality of the musculature of the pelvis (HP:0001469)1.97605305
85Abnormality of the hip-girdle musculature (HP:0001445)1.97605305
86Abnormal mitochondria in muscle tissue (HP:0008316)1.96477247
87Bulbar palsy (HP:0001283)1.95699983
88Palmoplantar keratoderma (HP:0000982)1.95414167
89Spinal rigidity (HP:0003306)1.95180697
90Hepatic necrosis (HP:0002605)1.94741791
91Increased muscle lipid content (HP:0009058)1.94331805
92Shoulder girdle muscle weakness (HP:0003547)1.91527245
93Pelvic girdle muscle weakness (HP:0003749)1.91457127
94Exercise intolerance (HP:0003546)1.90757053
95Testicular atrophy (HP:0000029)1.88485867
96Progressive muscle weakness (HP:0003323)1.86261918
97Abnormality of the foot musculature (HP:0001436)1.86247493
98Acute necrotizing encephalopathy (HP:0006965)1.85462674
99Foot dorsiflexor weakness (HP:0009027)1.83596452
100Central scotoma (HP:0000603)1.83154270
101Respiratory insufficiency due to muscle weakness (HP:0002747)1.82398305
102Conjunctival hamartoma (HP:0100780)1.81316964
103Long clavicles (HP:0000890)1.81036379
104Abnormality of the shoulder girdle musculature (HP:0001435)1.78071611
105Ragged-red muscle fibers (HP:0003200)1.76653324
106Cholelithiasis (HP:0001081)1.76648508
107Paralysis (HP:0003470)1.75730547
108Weak cry (HP:0001612)1.75439422
109Nonprogressive disorder (HP:0003680)1.72608691
110Hepatocellular necrosis (HP:0001404)1.72600466
111Increased intramyocellular lipid droplets (HP:0012240)1.69850132
112Metatarsus adductus (HP:0001840)1.68977577
113Popliteal pterygium (HP:0009756)1.68482265
114Type 2 muscle fiber atrophy (HP:0003554)1.62623742
115Ulnar deviation of finger (HP:0009465)1.59237092
116Oligomenorrhea (HP:0000876)1.51114902
117Muscle fiber atrophy (HP:0100295)1.49196010
118Limited hip movement (HP:0008800)1.47070046
119Steppage gait (HP:0003376)1.38672772
120Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.34345758
121Insulin-resistant diabetes mellitus (HP:0000831)1.29395204
122Congenital hip dislocation (HP:0001374)1.24925763
123Abnormality of potassium homeostasis (HP:0011042)1.24526710
124Adducted thumb (HP:0001181)1.23217675
125Easy fatigability (HP:0003388)1.20171029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.98109166
2TTN6.91964206
3* PHKG13.16301241
4* PHKG23.16301241
5PDK33.09206972
6PDK43.09206972
7DMPK2.82566776
8NEK12.78917791
9TRIB32.67019907
10PINK12.49084169
11NME12.48386351
12LMTK22.45683422
13PIK3CA2.30403662
14BCKDK2.29300347
15MUSK2.27152654
16PKN22.25468602
17MYLK2.20716684
18PIK3CG2.07314360
19MAP2K31.98602644
20PDK21.91246222
21MAP3K71.85874881
22MAPK121.52736402
23TIE11.51071189
24STK241.45708249
25MARK11.11488750
26RIPK11.03634273
27PRKAA11.02872197
28MAPKAPK30.99423614
29PRKAA20.98771151
30CCNB10.97006639
31LIMK10.95191735
32PRKD10.94497801
33ILK0.93573434
34MOS0.93020254
35MAP2K40.90832997
36CAMK2D0.90164740
37GRK70.85073695
38MAP2K60.83728386
39MAP3K30.83218394
40PAK30.80177464
41TRPM70.79994647
42ZAK0.79991042
43DYRK1B0.79215165
44ROCK10.76984324
45MAP3K130.69577961
46MAP3K50.68257303
47INSRR0.67485734
48EPHB10.65375294
49NEK90.64310672
50FLT30.63935390
51PKN10.60591736
52STK380.57412294
53SIK10.55016137
54CAMK2G0.54344406
55AKT20.53211751
56STK38L0.50321420
57TGFBR20.48185497
58CDC42BPA0.47773323
59CAMK40.46397410
60ROCK20.45620720
61TAOK10.44753758
62CAMK2B0.44650558
63TAOK20.42974457
64MAPK110.42943617
65PDGFRA0.42609077
66PTK60.41140411
67PRKACA0.38883729
68WNK10.38795719
69CAMK10.38260137
70MAPK130.38188046
71SGK20.37910155
72CAMK2A0.37541483
73PDPK10.35118065
74* PRKACB0.34575966
75TBK10.33784728
76SGK10.32562360
77MAP3K110.32514194
78PAK60.32339628
79WNK40.32092431
80ICK0.31043518
81PRKG10.30989483
82DAPK20.30818769
83PRKACG0.30474149
84STK40.29996317
85RPS6KB10.29387288
86PDK10.29281674
87RPS6KC10.28651080
88RPS6KL10.28651080
89CDK190.28322966
90PTK2B0.27905895
91DAPK30.27891898
92MAP3K10.26917926
93RPS6KA30.26644945
94MAPK70.26531608
95PRKCH0.26073014
96MAPK100.25117016
97PRKD30.24450994
98KDR0.24402553
99FER0.22818091
100MARK20.22578289
101RPS6KA60.22005776
102SGK30.21309868
103RPS6KA10.21056602
104EEF2K0.18241892
105RPS6KB20.18153102
106RET0.18011703
107SGK4940.17955665
108SGK2230.17955665
109MTOR0.16997994
110CAMK1G0.16681619
111STK110.16229541
112LATS10.15892277
113ARAF0.15668735
114MARK30.15117734
115PRKCE0.15084736
116NLK0.14320308
117KSR20.13364681
118LATS20.13343079
119ZAP700.12257937
120LRRK20.11248246
121PRPF4B0.11048809
122MAPK40.10855400
123ERBB30.10677536
124RAF10.10556379
125MAP2K10.10377292
126TNK20.09208710
127EPHA30.08874319
128KSR10.05259182
129MAP2K20.04932004
130MAPK90.04470582
131MAP3K100.04338597
132GSK3B0.04336098
133MAPK80.04144461

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.53527274
2Cardiac muscle contraction_Homo sapiens_hsa042604.18696413
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.15401643
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.01297809
5Dilated cardiomyopathy_Homo sapiens_hsa054143.83828611
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.05553505
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.00809102
8Propanoate metabolism_Homo sapiens_hsa006402.91835907
9Parkinsons disease_Homo sapiens_hsa050122.51714161
10Carbon metabolism_Homo sapiens_hsa012002.44841810
11Fatty acid degradation_Homo sapiens_hsa000712.43578955
12Oxidative phosphorylation_Homo sapiens_hsa001902.32703703
13Alzheimers disease_Homo sapiens_hsa050101.99400345
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.91807920
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90013276
16Fatty acid metabolism_Homo sapiens_hsa012121.87148594
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79170453
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65908709
19Pyruvate metabolism_Homo sapiens_hsa006201.64686164
20Viral myocarditis_Homo sapiens_hsa054161.59123667
21Huntingtons disease_Homo sapiens_hsa050161.38049203
22Biosynthesis of amino acids_Homo sapiens_hsa012301.35573933
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.30899340
24* Glucagon signaling pathway_Homo sapiens_hsa049221.30834366
25Oxytocin signaling pathway_Homo sapiens_hsa049211.30477237
26* Insulin resistance_Homo sapiens_hsa049311.26494519
27Nitrogen metabolism_Homo sapiens_hsa009101.25251401
28* Insulin signaling pathway_Homo sapiens_hsa049101.25211303
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23306948
30Calcium signaling pathway_Homo sapiens_hsa040201.22585145
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17195130
32Circadian rhythm_Homo sapiens_hsa047101.16455890
33* Starch and sucrose metabolism_Homo sapiens_hsa005001.11208504
34AMPK signaling pathway_Homo sapiens_hsa041521.10089788
35Galactose metabolism_Homo sapiens_hsa000521.04447332
36Butanoate metabolism_Homo sapiens_hsa006500.98624992
37Fructose and mannose metabolism_Homo sapiens_hsa000510.97174122
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96263702
39Fatty acid elongation_Homo sapiens_hsa000620.93963587
40PPAR signaling pathway_Homo sapiens_hsa033200.92200935
41Vascular smooth muscle contraction_Homo sapiens_hsa042700.86947293
42Focal adhesion_Homo sapiens_hsa045100.83766214
43Long-term potentiation_Homo sapiens_hsa047200.82690697
44Arginine and proline metabolism_Homo sapiens_hsa003300.80741777
45Tight junction_Homo sapiens_hsa045300.80678688
46HIF-1 signaling pathway_Homo sapiens_hsa040660.78017534
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.76968328
48Gastric acid secretion_Homo sapiens_hsa049710.76188490
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73755273
50Arginine biosynthesis_Homo sapiens_hsa002200.73105366
51Fatty acid biosynthesis_Homo sapiens_hsa000610.70799241
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69745391
53Renin secretion_Homo sapiens_hsa049240.69258677
54Type II diabetes mellitus_Homo sapiens_hsa049300.66604238
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60378459
56beta-Alanine metabolism_Homo sapiens_hsa004100.59413936
57Insulin secretion_Homo sapiens_hsa049110.57428786
58Lysine degradation_Homo sapiens_hsa003100.51949599
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51660932
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50444528
61GnRH signaling pathway_Homo sapiens_hsa049120.47794417
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46515538
63Tryptophan metabolism_Homo sapiens_hsa003800.46036748
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45209292
65Long-term depression_Homo sapiens_hsa047300.45156702
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44126399
67Circadian entrainment_Homo sapiens_hsa047130.43609525
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42935175
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42767418
70mTOR signaling pathway_Homo sapiens_hsa041500.41659752
71cAMP signaling pathway_Homo sapiens_hsa040240.40986928
72Pentose phosphate pathway_Homo sapiens_hsa000300.40960518
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39044630
74Regulation of autophagy_Homo sapiens_hsa041400.38842705
75Phenylalanine metabolism_Homo sapiens_hsa003600.37959769
76ECM-receptor interaction_Homo sapiens_hsa045120.37468373
77VEGF signaling pathway_Homo sapiens_hsa043700.35362021
78Amoebiasis_Homo sapiens_hsa051460.34746418
79Adherens junction_Homo sapiens_hsa045200.33919196
80Platelet activation_Homo sapiens_hsa046110.32786217
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30279801
82FoxO signaling pathway_Homo sapiens_hsa040680.29580414
83Peroxisome_Homo sapiens_hsa041460.29418758
84Amphetamine addiction_Homo sapiens_hsa050310.29381924
85Histidine metabolism_Homo sapiens_hsa003400.28035710
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27084960
87Cholinergic synapse_Homo sapiens_hsa047250.26628668
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26346672
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.24391249
90MAPK signaling pathway_Homo sapiens_hsa040100.23783847
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22998570
92Proteoglycans in cancer_Homo sapiens_hsa052050.22839947
93Renal cell carcinoma_Homo sapiens_hsa052110.22664966
94Pancreatic secretion_Homo sapiens_hsa049720.21915311
95Purine metabolism_Homo sapiens_hsa002300.20093011
96Salivary secretion_Homo sapiens_hsa049700.19138854
97Olfactory transduction_Homo sapiens_hsa047400.18552777
98Glioma_Homo sapiens_hsa052140.18067338
99Phototransduction_Homo sapiens_hsa047440.14788531
100Gap junction_Homo sapiens_hsa045400.14717726
101Melanogenesis_Homo sapiens_hsa049160.14531808
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13978070
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.13448680
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13425288
105* Metabolic pathways_Homo sapiens_hsa011000.12568515
106Bile secretion_Homo sapiens_hsa049760.12041289
107GABAergic synapse_Homo sapiens_hsa047270.11850569
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10886722
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10180945
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.10146213
111Fat digestion and absorption_Homo sapiens_hsa049750.09951975
112Dorso-ventral axis formation_Homo sapiens_hsa043200.09524019
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.08506401
114Dopaminergic synapse_Homo sapiens_hsa047280.08228974
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.08006683
116Tyrosine metabolism_Homo sapiens_hsa003500.07648216
117Ovarian steroidogenesis_Homo sapiens_hsa049130.07441969
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.06922215

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