PYGO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.39611452
2axon ensheathment in central nervous system (GO:0032291)8.39611452
3neuron cell-cell adhesion (GO:0007158)4.93234719
4L-amino acid import (GO:0043092)4.70443483
5fatty acid elongation (GO:0030497)4.53214700
6long-chain fatty acid biosynthetic process (GO:0042759)4.48118001
7myelination (GO:0042552)4.38642697
8ensheathment of neurons (GO:0007272)4.33914789
9axon ensheathment (GO:0008366)4.33914789
10presynaptic membrane assembly (GO:0097105)4.17968967
11presynaptic membrane organization (GO:0097090)4.14689181
12neuronal action potential propagation (GO:0019227)4.08993396
13negative regulation of neurotransmitter transport (GO:0051589)4.08851734
14neuron recognition (GO:0008038)4.04617493
15pyrimidine nucleobase catabolic process (GO:0006208)3.91544682
16axonal fasciculation (GO:0007413)3.79364335
17negative regulation of protein localization to cell surface (GO:2000009)3.76164663
18negative regulation of neurotransmitter secretion (GO:0046929)3.71479915
19transmission of nerve impulse (GO:0019226)3.70559691
20dendritic spine morphogenesis (GO:0060997)3.63542042
21establishment of mitochondrion localization (GO:0051654)3.62444775
22amino acid import (GO:0043090)3.58240026
23muscle filament sliding (GO:0030049)3.57604846
24actin-myosin filament sliding (GO:0033275)3.57604846
25auditory behavior (GO:0031223)3.54908931
26neurotransmitter uptake (GO:0001504)3.51536942
27cerebral cortex radially oriented cell migration (GO:0021799)3.49578640
28limb bud formation (GO:0060174)3.48086212
29sarcoplasmic reticulum calcium ion transport (GO:0070296)3.45599693
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43011980
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.27249005
32positive regulation of oligodendrocyte differentiation (GO:0048714)3.26633520
33adult walking behavior (GO:0007628)3.25415084
34regulation of collateral sprouting (GO:0048670)3.23735886
35mechanosensory behavior (GO:0007638)3.22192796
36glycerophospholipid catabolic process (GO:0046475)3.20703092
37dendrite morphogenesis (GO:0048813)3.14956322
38actin-mediated cell contraction (GO:0070252)3.14072289
39protein localization to synapse (GO:0035418)3.13461274
40apical protein localization (GO:0045176)3.10081069
41neuron fate determination (GO:0048664)3.06646797
42glutamate receptor signaling pathway (GO:0007215)3.06055198
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04663078
44neuronal stem cell maintenance (GO:0097150)3.04566130
45regulation of skeletal muscle contraction (GO:0014819)3.04270453
46vocalization behavior (GO:0071625)3.03821787
47synaptic vesicle exocytosis (GO:0016079)3.03739824
48positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03532279
49import into cell (GO:0098657)3.03357669
50retinal ganglion cell axon guidance (GO:0031290)3.01235510
51nucleobase catabolic process (GO:0046113)2.99124516
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.95016132
53gamma-aminobutyric acid signaling pathway (GO:0007214)2.93356175
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.92970731
55regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.92197648
56neuron remodeling (GO:0016322)2.91967124
57oligodendrocyte differentiation (GO:0048709)2.91406041
58photoreceptor cell differentiation (GO:0046530)2.86655390
59eye photoreceptor cell differentiation (GO:0001754)2.86655390
60regulation of glutamate receptor signaling pathway (GO:1900449)2.86604450
61somite development (GO:0061053)2.85935902
62positive regulation of synapse assembly (GO:0051965)2.85387845
63asymmetric protein localization (GO:0008105)2.85205143
64regulation of relaxation of muscle (GO:1901077)2.84900332
65negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.84323734
66myofibril assembly (GO:0030239)2.83207096
67regulation of short-term neuronal synaptic plasticity (GO:0048172)2.83137393
68response to methylmercury (GO:0051597)2.83055049
69synaptic transmission, glutamatergic (GO:0035249)2.79606860
70postsynaptic membrane organization (GO:0001941)2.79057277
71negative regulation of axonogenesis (GO:0050771)2.78248447
72negative regulation of axon guidance (GO:1902668)2.77775081
73positive regulation of action potential (GO:0045760)2.77409686
74behavioral response to nicotine (GO:0035095)2.76957951
75positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.76247767
76neuron-neuron synaptic transmission (GO:0007270)2.75930181
77cerebellar granule cell differentiation (GO:0021707)2.75075490
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73565726
79layer formation in cerebral cortex (GO:0021819)2.73508331
80response to auditory stimulus (GO:0010996)2.72857984
81neuronal ion channel clustering (GO:0045161)2.72246142
82membrane tubulation (GO:0097320)2.71294046
83central nervous system projection neuron axonogenesis (GO:0021952)2.71051742
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.70828870
85gamma-aminobutyric acid transport (GO:0015812)2.70007628
86otic vesicle formation (GO:0030916)2.68675879
87cell migration in hindbrain (GO:0021535)2.68160847
88negative regulation of axon extension (GO:0030517)2.67904641
89sensory perception of smell (GO:0007608)2.67373866
90dendrite development (GO:0016358)2.67203262
91myelin maintenance (GO:0043217)2.67125606
92substantia nigra development (GO:0021762)2.65073567
93cardiac myofibril assembly (GO:0055003)2.64166793
94locomotory exploration behavior (GO:0035641)2.63902607
95regulation of cell communication by electrical coupling (GO:0010649)2.62771250
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.61776950
97regulation of neuronal synaptic plasticity (GO:0048168)2.61701319
98glutamate secretion (GO:0014047)2.61463852
99regulation of dendritic spine morphogenesis (GO:0061001)2.61128729
100nonmotile primary cilium assembly (GO:0035058)2.60856330
101cardiac muscle cell development (GO:0055013)2.57712201
102synaptic vesicle maturation (GO:0016188)2.56937094
103neuromuscular synaptic transmission (GO:0007274)2.56362808
104regulation of synaptic vesicle exocytosis (GO:2000300)2.56225669
105regulation of sarcomere organization (GO:0060297)2.55885647
106regulation of timing of cell differentiation (GO:0048505)2.55660039
107startle response (GO:0001964)2.55244401
108regulation of axon guidance (GO:1902667)2.54417493
109mating behavior (GO:0007617)2.52958245
110astrocyte development (GO:0014002)2.51725462
111protein palmitoylation (GO:0018345)2.51436302
112regulation of development, heterochronic (GO:0040034)2.51159442
113synapse assembly (GO:0007416)2.50484419
114nerve growth factor signaling pathway (GO:0038180)2.49318044
115appendage development (GO:0048736)2.48961904
116limb development (GO:0060173)2.48961904
117positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47694526
118negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46715124
119protein polyglutamylation (GO:0018095)2.46312501
120myotube differentiation (GO:0014902)2.45826249
121lateral sprouting from an epithelium (GO:0060601)2.45774797
122negative chemotaxis (GO:0050919)2.45266405
123spinal cord development (GO:0021510)2.44836666
124nucleus localization (GO:0051647)2.44573887
125regulation of dendritic spine development (GO:0060998)2.44387079
126magnesium ion transport (GO:0015693)2.44191943
127regulation of long-term neuronal synaptic plasticity (GO:0048169)2.43234221
128cardiac cell development (GO:0055006)2.42244620
129sarcomere organization (GO:0045214)2.41893635
130substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.41186579
131substrate-independent telencephalic tangential migration (GO:0021826)2.41186579
132isoprenoid biosynthetic process (GO:0008299)2.41114525
133adult locomotory behavior (GO:0008344)2.41042396
134negative regulation of oligodendrocyte differentiation (GO:0048715)2.39929146
135cranial nerve development (GO:0021545)2.39865822
136organ growth (GO:0035265)2.39644506
137regulation of feeding behavior (GO:0060259)2.39113241
138regulation of synapse assembly (GO:0051963)2.39071236
139positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.38662176
140C4-dicarboxylate transport (GO:0015740)2.38648534
141regulation of cardioblast proliferation (GO:0003264)2.38451503
142regulation of secondary heart field cardioblast proliferation (GO:0003266)2.38451503
143artery development (GO:0060840)2.37662524
144response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.37275094
145regulation of respiratory system process (GO:0044065)2.34706494
146positive regulation of cardiac muscle cell differentiation (GO:2000727)2.34170593
147central nervous system neuron axonogenesis (GO:0021955)2.33166350
148epithelial cilium movement (GO:0003351)2.32272916
149muscle fiber development (GO:0048747)2.28633623
150cell morphogenesis involved in neuron differentiation (GO:0048667)2.27494056
151G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.26878074
152positive regulation of embryonic development (GO:0040019)2.26637909
153olfactory bulb development (GO:0021772)2.26107475
154negative regulation of axon extension involved in axon guidance (GO:0048843)2.24193373
155actin filament-based movement (GO:0030048)2.23984537
156calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.23557346
157striated muscle contraction (GO:0006941)2.23243066
158establishment of nucleus localization (GO:0040023)2.23080038
159axon extension (GO:0048675)2.22354351
160cochlea development (GO:0090102)2.22140854
161response to inactivity (GO:0014854)2.20746863
162detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.20002589
163head development (GO:0060322)2.19623380
164regulation of axon extension involved in axon guidance (GO:0048841)2.19154123
165axon extension involved in axon guidance (GO:0048846)2.18613605
166neuron projection extension involved in neuron projection guidance (GO:1902284)2.18613605
167behavioral response to ethanol (GO:0048149)2.18604664
168forebrain neuron differentiation (GO:0021879)2.18133466
169cardiac septum development (GO:0003279)2.16817115
170response to pheromone (GO:0019236)2.16734455
171myoblast fusion (GO:0007520)2.16413840
172cranial nerve morphogenesis (GO:0021602)2.15354790
173interkinetic nuclear migration (GO:0022027)2.14273944
174hindbrain development (GO:0030902)2.14083559
175innervation (GO:0060384)2.13962495
176regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.13900430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.94835375
2GBX2_23144817_ChIP-Seq_PC3_Human3.86568124
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88014470
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76408028
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75388726
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.57879674
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50289422
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50289422
9TAF15_26573619_Chip-Seq_HEK293_Human2.47044169
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.43514075
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36338514
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34597567
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32501203
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28590394
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16355404
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15157322
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09289896
18AR_21572438_ChIP-Seq_LNCaP_Human2.09107999
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.07929664
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06580148
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06116181
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.05101997
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.00666329
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.00581458
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92407750
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90535795
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81812006
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80742694
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80243529
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.78332169
31VDR_22108803_ChIP-Seq_LS180_Human1.76066194
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75692836
33DROSHA_22980978_ChIP-Seq_HELA_Human1.73919093
34EWS_26573619_Chip-Seq_HEK293_Human1.72892653
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72719151
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71383688
37REST_21632747_ChIP-Seq_MESCs_Mouse1.70830110
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70422139
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66652844
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64638619
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.64286553
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63699142
43P300_19829295_ChIP-Seq_ESCs_Human1.57779424
44ER_23166858_ChIP-Seq_MCF-7_Human1.56329094
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53989684
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.52201550
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46943065
48FUS_26573619_Chip-Seq_HEK293_Human1.46756065
49RNF2_27304074_Chip-Seq_NSC_Mouse1.45465803
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.45443914
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45409136
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43586322
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43504330
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.39541571
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38554177
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37560919
57IGF1R_20145208_ChIP-Seq_DFB_Human1.32281382
58* RARB_27405468_Chip-Seq_BRAIN_Mouse1.31403636
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30199557
60CBP_20019798_ChIP-Seq_JUKART_Human1.30199557
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.29436234
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27294068
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27087522
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26566760
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26301074
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23604009
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.23055409
68AHR_22903824_ChIP-Seq_MCF-7_Human1.22271123
69BCAT_22108803_ChIP-Seq_LS180_Human1.21452245
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21193084
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21095625
72STAT3_23295773_ChIP-Seq_U87_Human1.19306677
73CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18661381
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.18587121
75* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18164590
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.18068885
77SOX9_26525672_Chip-Seq_HEART_Mouse1.17807285
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16961049
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.16303309
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15704999
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15685537
82* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14287476
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13682651
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13647267
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.13193562
86TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12432888
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.12013920
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.11411047
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10233063
90TCF4_23295773_ChIP-Seq_U87_Human1.09640164
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09208083
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09208083
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09151884
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08772014
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08398910
96TP53_18474530_ChIP-ChIP_U2OS_Human1.07978898
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07762073
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.07415353
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06718680
100RUNX2_22187159_ChIP-Seq_PCA_Human1.06356351
101* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05593089
102AR_25329375_ChIP-Seq_VCAP_Human1.05235334
103KDM2B_26808549_Chip-Seq_REH_Human1.05219834
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.04630226
105* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03741561
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.03281660
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02378162
108WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02307633
109ZNF274_21170338_ChIP-Seq_K562_Hela1.02141369
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01611297
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01534504
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.01440870
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98791817
114E2F1_18555785_Chip-Seq_ESCs_Mouse0.97362952
115* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96323122
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95426543
117SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94499758
118JUN_21703547_ChIP-Seq_K562_Human0.92291540
119TAL1_26923725_Chip-Seq_HPCs_Mouse0.91933087
120TP53_16413492_ChIP-PET_HCT116_Human0.91418845
121P53_22387025_ChIP-Seq_ESCs_Mouse0.91127722
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90822850
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90822850
124LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90066095

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.05395106
2MP0004859_abnormal_synaptic_plasticity3.57473632
3MP0004270_analgesia3.26411984
4MP0000920_abnormal_myelination2.87118060
5MP0003635_abnormal_synaptic_transmissio2.75522710
6MP0000569_abnormal_digit_pigmentation2.73463222
7MP0005423_abnormal_somatic_nervous2.62920615
8MP0001486_abnormal_startle_reflex2.60822267
9MP0003646_muscle_fatigue2.52981483
10MP0002064_seizures2.48889643
11MP0000778_abnormal_nervous_system2.46747922
12MP0002272_abnormal_nervous_system2.46322998
13MP0009745_abnormal_behavioral_response2.35549950
14MP0000749_muscle_degeneration2.29091006
15MP0009046_muscle_twitch2.24996208
16MP0005171_absent_coat_pigmentation2.22828794
17MP0002063_abnormal_learning/memory/cond2.21958917
18MP0003136_yellow_coat_color2.21805592
19MP0001529_abnormal_vocalization2.21599753
20MP0005409_darkened_coat_color2.09692471
21MP0002734_abnormal_mechanical_nocicepti2.05623357
22MP0002572_abnormal_emotion/affect_behav2.02764210
23MP0004742_abnormal_vestibular_system1.94018344
24MP0001984_abnormal_olfaction1.90948643
25MP0004885_abnormal_endolymph1.88252736
26MP0001905_abnormal_dopamine_level1.80912640
27MP0003690_abnormal_glial_cell1.73668340
28MP0001485_abnormal_pinna_reflex1.72307549
29MP0001440_abnormal_grooming_behavior1.67826004
30MP0005187_abnormal_penis_morphology1.65979958
31MP0004145_abnormal_muscle_electrophysio1.65599923
32MP0004142_abnormal_muscle_tone1.64744411
33MP0002184_abnormal_innervation1.64522608
34MP0003329_amyloid_beta_deposits1.60729416
35MP0002067_abnormal_sensory_capabilities1.60103860
36MP0006276_abnormal_autonomic_nervous1.59142733
37MP0004215_abnormal_myocardial_fiber1.57265698
38MP0001968_abnormal_touch/_nociception1.56590775
39MP0003634_abnormal_glial_cell1.55286527
40MP0002882_abnormal_neuron_morphology1.52122907
41MP0001970_abnormal_pain_threshold1.51149799
42MP0003950_abnormal_plasma_membrane1.50119363
43MP0005551_abnormal_eye_electrophysiolog1.49891919
44MP0000566_synostosis1.49285109
45MP0005645_abnormal_hypothalamus_physiol1.48919535
46MP0000955_abnormal_spinal_cord1.48633234
47MP0002653_abnormal_ependyma_morphology1.46333553
48MP0002735_abnormal_chemical_nociception1.43413031
49MP0008569_lethality_at_weaning1.42944976
50MP0005620_abnormal_muscle_contractility1.42078947
51MP0002557_abnormal_social/conspecific_i1.41141087
52MP0003890_abnormal_embryonic-extraembry1.37430504
53MP0002234_abnormal_pharynx_morphology1.36810684
54MP0005386_behavior/neurological_phenoty1.35457214
55MP0004924_abnormal_behavior1.35457214
56MP0004043_abnormal_pH_regulation1.34658369
57MP0002106_abnormal_muscle_physiology1.34434541
58MP0001188_hyperpigmentation1.34317224
59MP0002229_neurodegeneration1.32993178
60MP0004084_abnormal_cardiac_muscle1.32677570
61MP0002066_abnormal_motor_capabilities/c1.29718583
62MP0002102_abnormal_ear_morphology1.29301513
63MP0003938_abnormal_ear_development1.28626495
64MP0002752_abnormal_somatic_nervous1.27694350
65MP0005369_muscle_phenotype1.26447529
66MP0003121_genomic_imprinting1.26110159
67MP0002733_abnormal_thermal_nociception1.23187546
68MP0001501_abnormal_sleep_pattern1.22809674
69MP0003632_abnormal_nervous_system1.21668690
70MP0001963_abnormal_hearing_physiology1.20095119
71MP0004133_heterotaxia1.18821310
72MP0002108_abnormal_muscle_morphology1.17793797
73MP0000631_abnormal_neuroendocrine_gland1.15961309
74MP0005503_abnormal_tendon_morphology1.14961678
75MP0010030_abnormal_orbit_morphology1.14425500
76MP0002751_abnormal_autonomic_nervous1.14412819
77* MP0002152_abnormal_brain_morphology1.13661722
78* MP0000534_abnormal_ureter_morphology1.12405764
79MP0002822_catalepsy1.10813842
80MP0003631_nervous_system_phenotype1.10310079
81MP0005646_abnormal_pituitary_gland1.09869023
82MP0005410_abnormal_fertilization1.08534013
83MP0000462_abnormal_digestive_system1.07887909
84MP0000747_muscle_weakness1.07680066
85MP0000026_abnormal_inner_ear1.07455597
86MP0000759_abnormal_skeletal_muscle1.06326181
87MP0001299_abnormal_eye_distance/1.04738919
88MP0002736_abnormal_nociception_after1.03979443
89MP0002269_muscular_atrophy1.03177443
90MP0003633_abnormal_nervous_system1.02450245
91MP0003122_maternal_imprinting1.02316202
92MP0004087_abnormal_muscle_fiber1.02269124
93MP0000013_abnormal_adipose_tissue1.02093444
94MP0004811_abnormal_neuron_physiology1.01729693
95MP0000751_myopathy1.01489361
96MP0009250_abnormal_appendicular_skeleto1.00049579
97MP0004134_abnormal_chest_morphology0.99909168
98MP0006072_abnormal_retinal_apoptosis0.97754810
99MP0005394_taste/olfaction_phenotype0.97574165
100MP0005499_abnormal_olfactory_system0.97574165
101MP0003137_abnormal_impulse_conducting0.97492128
102MP0009384_cardiac_valve_regurgitation0.96622127
103MP0002282_abnormal_trachea_morphology0.96540065
104MP0001293_anophthalmia0.94876868
105MP0000750_abnormal_muscle_regeneration0.94747264
106MP0003937_abnormal_limbs/digits/tail_de0.94461384
107MP0009780_abnormal_chondrocyte_physiolo0.93659087
108* MP0003942_abnormal_urinary_system0.93501306
109MP0005248_abnormal_Harderian_gland0.93042441
110MP0003935_abnormal_craniofacial_develop0.92633864
111MP0008789_abnormal_olfactory_epithelium0.92562430
112MP0001177_atelectasis0.92326897
113MP0005623_abnormal_meninges_morphology0.92261026
114MP0002638_abnormal_pupillary_reflex0.91693761
115MP0002127_abnormal_cardiovascular_syste0.91327475
116* MP0005195_abnormal_posterior_eye0.90301127
117MP0002249_abnormal_larynx_morphology0.89752108
118MP0000733_abnormal_muscle_development0.89534570
119MP0002938_white_spotting0.89514913
120MP0000427_abnormal_hair_cycle0.88589626
121MP0003119_abnormal_digestive_system0.88000828
122MP0004130_abnormal_muscle_cell0.87825435
123MP0006292_abnormal_olfactory_placode0.85118892
124MP0005391_vision/eye_phenotype0.84858025
125MP0002932_abnormal_joint_morphology0.84435381
126MP0001502_abnormal_circadian_rhythm0.83867383
127* MP0003861_abnormal_nervous_system0.82578725
128MP0003385_abnormal_body_wall0.81210522
129MP0002837_dystrophic_cardiac_calcinosis0.78968044
130MP0004085_abnormal_heartbeat0.78887469
131MP0005253_abnormal_eye_physiology0.78723747
132MP0003787_abnormal_imprinting0.76857721
133MP0004381_abnormal_hair_follicle0.76483241
134MP0001346_abnormal_lacrimal_gland0.76377084
135MP0000049_abnormal_middle_ear0.75782466
136MP0000372_irregular_coat_pigmentation0.70836836
137MP0000762_abnormal_tongue_morphology0.69062692
138MP0002233_abnormal_nose_morphology0.68079055
139MP0004036_abnormal_muscle_relaxation0.67052179
140MP0003755_abnormal_palate_morphology0.66151043
141MP0001943_abnormal_respiration0.66110289

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.09229161
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.07469190
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.07469190
4Nemaline bodies (HP:0003798)4.98110889
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.90735096
6Neurofibrillary tangles (HP:0002185)4.61570199
7Focal motor seizures (HP:0011153)4.39477638
8Abnormality of the corticospinal tract (HP:0002492)4.14262012
9Myokymia (HP:0002411)4.11782606
10Type 1 muscle fiber predominance (HP:0003803)3.88926875
11Insidious onset (HP:0003587)3.56854149
12Termporal pattern (HP:0011008)3.56854149
13Exercise-induced muscle cramps (HP:0003710)3.49513083
14Cerebral inclusion bodies (HP:0100314)3.49201578
15Calf muscle hypertrophy (HP:0008981)3.45223922
16Focal seizures (HP:0007359)3.36101693
17Retinal dysplasia (HP:0007973)3.30616535
18Supranuclear gaze palsy (HP:0000605)3.23316496
19Sensory axonal neuropathy (HP:0003390)3.04337865
20Peripheral hypomyelination (HP:0007182)3.02789547
21Spastic gait (HP:0002064)2.98505316
22Atonic seizures (HP:0010819)2.97734042
23Abnormality of the calf musculature (HP:0001430)2.95600188
24Scanning speech (HP:0002168)2.88235580
25Epileptic encephalopathy (HP:0200134)2.81795004
26Alacrima (HP:0000522)2.80525681
27Distal arthrogryposis (HP:0005684)2.78886154
28Broad-based gait (HP:0002136)2.77946259
29Ankle clonus (HP:0011448)2.72050830
30Dysmetria (HP:0001310)2.70883829
31Hyperventilation (HP:0002883)2.68723996
32Hemiparesis (HP:0001269)2.65990385
33Exercise-induced myalgia (HP:0003738)2.62817845
34Parakeratosis (HP:0001036)2.54746071
35Progressive cerebellar ataxia (HP:0002073)2.53480372
36Dialeptic seizures (HP:0011146)2.51364970
37Rimmed vacuoles (HP:0003805)2.47632676
38Anteriorly placed anus (HP:0001545)2.45958004
39Pancreatic fibrosis (HP:0100732)2.42666705
40Pancreatic cysts (HP:0001737)2.41258011
41Intention tremor (HP:0002080)2.40218871
42Coronal craniosynostosis (HP:0004440)2.38365924
43Abnormality of glycolysis (HP:0004366)2.36846648
44Increased serum pyruvate (HP:0003542)2.36846648
45Thickened helices (HP:0000391)2.36767565
46Absent septum pellucidum (HP:0001331)2.34960062
47Molar tooth sign on MRI (HP:0002419)2.34948662
48Abnormality of midbrain morphology (HP:0002418)2.34948662
49Calcaneovalgus deformity (HP:0001848)2.34818435
50Aplasia of the phalanges of the hand (HP:0009802)2.32876648
51Aplasia involving bones of the extremities (HP:0009825)2.32876648
52Aplasia involving bones of the upper limbs (HP:0009823)2.32876648
53True hermaphroditism (HP:0010459)2.30830754
54Generalized tonic-clonic seizures (HP:0002069)2.28142729
55Nephronophthisis (HP:0000090)2.26189972
56Clumsiness (HP:0002312)2.24980116
57Megalencephaly (HP:0001355)2.23196281
58Absence seizures (HP:0002121)2.21730623
59Action tremor (HP:0002345)2.21596607
60Muscle hypertrophy of the lower extremities (HP:0008968)2.21097621
61Abnormality of the ischium (HP:0003174)2.21085825
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.20907794
63Absent/shortened dynein arms (HP:0200106)2.20907794
64Deformed tarsal bones (HP:0008119)2.20352153
65Truncal ataxia (HP:0002078)2.20242639
66Febrile seizures (HP:0002373)2.20222599
67Decreased lacrimation (HP:0000633)2.19470054
68Excessive salivation (HP:0003781)2.18699522
69Drooling (HP:0002307)2.18699522
70Acute necrotizing encephalopathy (HP:0006965)2.18030809
71Leukodystrophy (HP:0002415)2.17665442
72Onion bulb formation (HP:0003383)2.16902911
73Lower limb muscle weakness (HP:0007340)2.15184863
74Intestinal atresia (HP:0011100)2.14412443
75Chronic hepatic failure (HP:0100626)2.13836683
76Progressive inability to walk (HP:0002505)2.13689786
77Synostosis involving the elbow (HP:0003938)2.11861618
78Humeroradial synostosis (HP:0003041)2.11861618
79Optic nerve hypoplasia (HP:0000609)2.10735589
80Abnormality of the septum pellucidum (HP:0007375)2.09749207
81Pheochromocytoma (HP:0002666)2.08768740
82Absent phalangeal crease (HP:0006109)2.08663292
83Vaginal atresia (HP:0000148)2.08170782
84Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05851272
85Synostosis involving bones of the feet (HP:0009140)2.04178587
86Synostosis involving bones of the lower limbs (HP:0009138)2.04178587
87Genital tract atresia (HP:0001827)2.02365568
88Fetal akinesia sequence (HP:0001989)2.02247776
89Dysdiadochokinesis (HP:0002075)2.01109030
90Limb dystonia (HP:0002451)2.00223153
91Gaze-evoked nystagmus (HP:0000640)2.00063588
92Split foot (HP:0001839)1.99690769
93Gait imbalance (HP:0002141)1.98639790
94Abnormal auditory evoked potentials (HP:0006958)1.98628689
95Abnormality of the renal medulla (HP:0100957)1.97986950
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97345360
97Progressive macrocephaly (HP:0004481)1.95686782
98Congenital primary aphakia (HP:0007707)1.95298845
99Round ear (HP:0100830)1.94372508
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.94211843
101Myotonia (HP:0002486)1.92676791
102Long clavicles (HP:0000890)1.92118783
103Septo-optic dysplasia (HP:0100842)1.91644332
104Type II lissencephaly (HP:0007260)1.91504225
105Hip contracture (HP:0003273)1.90668246
106Abnormal ciliary motility (HP:0012262)1.90413495
107Abnormal finger flexion creases (HP:0006143)1.90407394
108Subaortic stenosis (HP:0001682)1.89811832
109Abnormality of the left ventricular outflow tract (HP:0011103)1.89811832
110Hypoplastic ischia (HP:0003175)1.88918759
111Anophthalmia (HP:0000528)1.88618478
112Gastrointestinal atresia (HP:0002589)1.87200443
113Absent speech (HP:0001344)1.86441499
114Neuroendocrine neoplasm (HP:0100634)1.86168575
115Blue irides (HP:0000635)1.85571848
116Metabolic alkalosis (HP:0200114)1.85427038
117Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85077012
118Increased circulating renin level (HP:0000848)1.83386637
119Medial flaring of the eyebrow (HP:0010747)1.82879537
120Limited hip movement (HP:0008800)1.82549690
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.82303117
122Intellectual disability, moderate (HP:0002342)1.77540857
123Tarsal synostosis (HP:0008368)1.77540235
124Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77514002
125Short 4th metacarpal (HP:0010044)1.77514002
126Cupped ear (HP:0000378)1.77276746
127EMG: myopathic abnormalities (HP:0003458)1.77003499
128Ulnar deviation of finger (HP:0009465)1.76480185
129Abnormality of the pubic bones (HP:0003172)1.75510565
130Urinary urgency (HP:0000012)1.75228945
131Abnormality of salivation (HP:0100755)1.74905051
132Nephrogenic diabetes insipidus (HP:0009806)1.74543107
133Urinary bladder sphincter dysfunction (HP:0002839)1.74541071
134Visual hallucinations (HP:0002367)1.74420856
135Abnormal respiratory motile cilium physiology (HP:0012261)1.73731787
136Hyporeflexia of lower limbs (HP:0002600)1.73634542
137Lissencephaly (HP:0001339)1.73582708
138Sclerocornea (HP:0000647)1.73244688
139Anxiety (HP:0000739)1.73243100
140Hypoplasia of the iris (HP:0007676)1.72556361
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70972769
142Postaxial hand polydactyly (HP:0001162)1.70648203
143Abnormality of the middle phalanges of the toes (HP:0010183)1.70588178
144Midline defect of the nose (HP:0004122)1.70226534
145Renal dysplasia (HP:0000110)1.69406515
146Bowel incontinence (HP:0002607)1.68807899
147Short tibia (HP:0005736)1.68375000
148Diplopia (HP:0000651)1.68293476
149Abnormality of binocular vision (HP:0011514)1.68293476
150White forelock (HP:0002211)1.67908466
151Frequent falls (HP:0002359)1.67687034
152Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.66044409
153Abnormal mitochondria in muscle tissue (HP:0008316)1.65828747
154Hypoplastic pelvis (HP:0008839)1.65504127
155Akinesia (HP:0002304)1.65284827
156Cerebellar dysplasia (HP:0007033)1.65035224
157Morphological abnormality of the inner ear (HP:0011390)1.64718092
158Widely spaced teeth (HP:0000687)1.64375247
159Specific learning disability (HP:0001328)1.64373786
160Generalized myoclonic seizures (HP:0002123)1.64186241
161Mixed hearing impairment (HP:0000410)1.64073839
162Keratoconus (HP:0000563)1.63359945
163Increased corneal curvature (HP:0100692)1.63359945
164Bifid tongue (HP:0010297)1.61383305
165Proximal amyotrophy (HP:0007126)1.60233279
166Short foot (HP:0001773)1.59021301
167Abnormality of the renal cortex (HP:0011035)1.58895511
168Left ventricular hypertrophy (HP:0001712)1.58117597
169Abnormality of the labia minora (HP:0012880)1.57744245
170Esophageal atresia (HP:0002032)1.56290711
171Anencephaly (HP:0002323)1.55716539
172Pachygyria (HP:0001302)1.55557009
173Maternal diabetes (HP:0009800)1.55001822
174Cutaneous finger syndactyly (HP:0010554)1.54848376
175Poor coordination (HP:0002370)1.53708890
176Myopathic facies (HP:0002058)1.53701940
177Aplasia/Hypoplasia of the sternum (HP:0006714)1.51907157
178Exotropia (HP:0000577)1.51370961
179Genetic anticipation (HP:0003743)1.50634772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.92541523
2OXSR13.07830805
3MARK13.00257047
4CASK2.90111023
5EPHA42.51729029
6FRK2.36453311
7NTRK32.34996469
8PNCK2.32070712
9PKN12.31163576
10WNK42.19647607
11MAP4K22.03182942
12BCR1.95459526
13TNIK1.95365285
14PINK11.88878540
15ERBB31.84984089
16FGFR21.81701492
17WNK11.72231784
18UHMK11.71678962
19MAPKAPK51.66419542
20MAP3K41.59121758
21MAPK131.57430599
22STK38L1.57328158
23CAMK2B1.54118952
24LATS11.54033333
25PHKG21.53308202
26PHKG11.53308202
27CSNK1A1L1.48936790
28CSNK1G31.48419210
29NTRK21.45215450
30MAP2K71.44383123
31EPHB11.44344931
32PAK61.43819820
33EPHA31.38990169
34CSNK1G21.33705757
35NTRK11.28770736
36MAP3K91.28577609
37WEE11.28341974
38CDK191.25781006
39MUSK1.24274278
40CAMK2D1.23510131
41FGR1.23158794
42BMPR1B1.22699004
43PAK31.21854264
44PRPF4B1.21217136
45CAMK2A1.20149832
46DYRK21.17772954
47CDK51.17028454
48CSNK1G11.16126522
49PBK1.15374222
50ROCK21.13101149
51TTN1.10566782
52LIMK11.10108600
53MINK11.10041488
54SGK2231.09670203
55SGK4941.09670203
56AKT31.07638076
57IRAK21.06002738
58SGK21.02674347
59MET1.00996790
60PLK20.99141340
61NEK60.95024803
62ICK0.94474018
63MARK20.93800692
64CCNB10.92548803
65GRK70.89175843
66BRSK20.88969438
67TRIM280.88668813
68CAMK2G0.87712122
69TYRO30.86483905
70PRKCE0.85142158
71ARAF0.84086148
72CAMK1G0.82249312
73CDK140.79822727
74ACVR1B0.79707512
75DYRK1A0.77859739
76TGFBR10.76072467
77CDK150.75212687
78PLK40.74804589
79CDK180.74073369
80KSR10.73800831
81LATS20.72978220
82CLK10.69640703
83BMPR20.69521548
84DAPK20.68011673
85NUAK10.67288477
86CDK11A0.65081760
87PRKCG0.64184839
88ADRBK10.63623333
89GRK50.62918417
90PRKD10.62491257
91MAP2K40.62073864
92ZAK0.61854140
93ROCK10.60875969
94PRKCQ0.60321261
95ADRBK20.59814709
96MAP3K70.59558770
97PIK3CG0.59403238
98MKNK10.58785222
99FYN0.58124748
100GRK10.57673803
101STK30.56183044
102CAMK40.56049952
103FES0.55719634
104WNK30.55219335
105ERBB40.54903653
106MAPK150.54675519
107PRKG10.54466564
108STK110.53601918
109BRD40.53398501
110DMPK0.53294792
111CDK80.49405570
112PRKD30.49392343
113PLK30.49269435
114INSRR0.48840912
115SGK10.48514618
116PRKAA20.46673338
117PRKAA10.46183539
118CAMKK20.46060955
119MKNK20.45642969
120PIK3CA0.45536221
121PRKCH0.45444503
122EPHB20.45383635
123DDR20.44128265
124PRKACB0.43666502
125CSNK1D0.43625650
126PDPK10.42825684
127CAMK10.42367567
128NME10.42322956
129OBSCN0.42154519
130NEK90.42130145
131PRKACA0.42059128
132SGK30.41771716
133CDK30.40424492
134MST40.40353625
135PTK2B0.40206817
136DYRK30.38258304
137DYRK1B0.35334861
138NEK10.35312753
139PLK10.34520941

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.32362352
2Nicotine addiction_Homo sapiens_hsa050332.81150163
3GABAergic synapse_Homo sapiens_hsa047272.48784594
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47149777
5Glutamatergic synapse_Homo sapiens_hsa047242.42819575
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37377810
7Fatty acid elongation_Homo sapiens_hsa000622.23611859
8Olfactory transduction_Homo sapiens_hsa047402.22521115
9Steroid biosynthesis_Homo sapiens_hsa001002.20678571
10Morphine addiction_Homo sapiens_hsa050322.14364530
11Circadian entrainment_Homo sapiens_hsa047132.06800560
12Axon guidance_Homo sapiens_hsa043601.98370227
13Propanoate metabolism_Homo sapiens_hsa006401.97535551
14Oxidative phosphorylation_Homo sapiens_hsa001901.93641124
15Serotonergic synapse_Homo sapiens_hsa047261.92114343
16Circadian rhythm_Homo sapiens_hsa047101.88728507
17Ether lipid metabolism_Homo sapiens_hsa005651.86921805
18Dopaminergic synapse_Homo sapiens_hsa047281.65272460
19Cardiac muscle contraction_Homo sapiens_hsa042601.61117711
20Synaptic vesicle cycle_Homo sapiens_hsa047211.60172493
21Salivary secretion_Homo sapiens_hsa049701.59952244
22Long-term depression_Homo sapiens_hsa047301.59675639
23Alzheimers disease_Homo sapiens_hsa050101.56094453
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53795499
25Taste transduction_Homo sapiens_hsa047421.53504481
26Cholinergic synapse_Homo sapiens_hsa047251.51669339
27Phototransduction_Homo sapiens_hsa047441.49927152
28Hippo signaling pathway_Homo sapiens_hsa043901.47799031
29Amphetamine addiction_Homo sapiens_hsa050311.47156989
30Gastric acid secretion_Homo sapiens_hsa049711.46351209
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46131413
32Parkinsons disease_Homo sapiens_hsa050121.45726792
33Long-term potentiation_Homo sapiens_hsa047201.44660134
34Renin secretion_Homo sapiens_hsa049241.31258642
35Cocaine addiction_Homo sapiens_hsa050301.30614459
36Fanconi anemia pathway_Homo sapiens_hsa034601.28478832
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27515627
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25196561
39Insulin secretion_Homo sapiens_hsa049111.24555826
40Collecting duct acid secretion_Homo sapiens_hsa049661.21765607
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20964539
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18988641
43Oxytocin signaling pathway_Homo sapiens_hsa049211.16275124
44Calcium signaling pathway_Homo sapiens_hsa040201.15552989
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13831246
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11413787
47Basal transcription factors_Homo sapiens_hsa030221.08469883
48TGF-beta signaling pathway_Homo sapiens_hsa043501.06928844
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.06059102
50Butanoate metabolism_Homo sapiens_hsa006501.05453216
51Vibrio cholerae infection_Homo sapiens_hsa051101.05252082
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99834834
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97642201
54cAMP signaling pathway_Homo sapiens_hsa040240.96965356
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96735721
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95373453
57Gap junction_Homo sapiens_hsa045400.94443866
58Sphingolipid metabolism_Homo sapiens_hsa006000.94155920
59Huntingtons disease_Homo sapiens_hsa050160.92599022
60Renal cell carcinoma_Homo sapiens_hsa052110.91734028
61Dilated cardiomyopathy_Homo sapiens_hsa054140.90551809
62Dorso-ventral axis formation_Homo sapiens_hsa043200.90299607
63Melanogenesis_Homo sapiens_hsa049160.90013129
64Ras signaling pathway_Homo sapiens_hsa040140.88453599
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.88303887
66Fatty acid biosynthesis_Homo sapiens_hsa000610.86211769
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85719991
68ECM-receptor interaction_Homo sapiens_hsa045120.85608599
69Oocyte meiosis_Homo sapiens_hsa041140.85350153
70ErbB signaling pathway_Homo sapiens_hsa040120.85324330
71Sulfur metabolism_Homo sapiens_hsa009200.84720800
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84655776
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81759207
74GnRH signaling pathway_Homo sapiens_hsa049120.81011764
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80918329
76Glucagon signaling pathway_Homo sapiens_hsa049220.79997035
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77288215
78Selenocompound metabolism_Homo sapiens_hsa004500.76715188
79Nitrogen metabolism_Homo sapiens_hsa009100.76506791
80Regulation of autophagy_Homo sapiens_hsa041400.75466489
81Ovarian steroidogenesis_Homo sapiens_hsa049130.75368800
82RNA degradation_Homo sapiens_hsa030180.74272541
83Vitamin B6 metabolism_Homo sapiens_hsa007500.72388697
84Pancreatic secretion_Homo sapiens_hsa049720.72235061
85Hedgehog signaling pathway_Homo sapiens_hsa043400.72191610
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71061224
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.71018695
88Tight junction_Homo sapiens_hsa045300.70799837
89Linoleic acid metabolism_Homo sapiens_hsa005910.70007263
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69089556
91Histidine metabolism_Homo sapiens_hsa003400.68760477
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.67597003
93AMPK signaling pathway_Homo sapiens_hsa041520.67522252
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64812217
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64116124
96beta-Alanine metabolism_Homo sapiens_hsa004100.63559823
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63103195
98Wnt signaling pathway_Homo sapiens_hsa043100.63050534
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62446674
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61683592
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61256894
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60949097
103Alcoholism_Homo sapiens_hsa050340.60236137
104Adherens junction_Homo sapiens_hsa045200.58815536
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58460945
106Protein digestion and absorption_Homo sapiens_hsa049740.58178263
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58166999
108Estrogen signaling pathway_Homo sapiens_hsa049150.57355129
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57183180
110Choline metabolism in cancer_Homo sapiens_hsa052310.56534301
111Fatty acid metabolism_Homo sapiens_hsa012120.56448112
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55468864
113MAPK signaling pathway_Homo sapiens_hsa040100.54784634
114Melanoma_Homo sapiens_hsa052180.54119120
115Protein export_Homo sapiens_hsa030600.53265713
116ABC transporters_Homo sapiens_hsa020100.49310829
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46800734
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45914790
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45816269
120Rap1 signaling pathway_Homo sapiens_hsa040150.45162951
121Focal adhesion_Homo sapiens_hsa045100.44634321
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44245237
123Rheumatoid arthritis_Homo sapiens_hsa053230.43925144
124Mineral absorption_Homo sapiens_hsa049780.43161072
125Basal cell carcinoma_Homo sapiens_hsa052170.42555601
126Arginine and proline metabolism_Homo sapiens_hsa003300.41675090
127Glioma_Homo sapiens_hsa052140.40461965
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39078895
129Type II diabetes mellitus_Homo sapiens_hsa049300.38293927
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37956515
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37635016
132Endocytosis_Homo sapiens_hsa041440.37118329
133Folate biosynthesis_Homo sapiens_hsa007900.36930276
134Thyroid hormone synthesis_Homo sapiens_hsa049180.36273793
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36149654

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