PYHIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)6.55189724
2cytidine metabolic process (GO:0046087)6.55189724
3cytidine catabolic process (GO:0006216)6.55189724
4pyrimidine ribonucleoside catabolic process (GO:0046133)5.98774867
5cellular response to interleukin-15 (GO:0071350)5.84696680
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.82609814
7DNA deamination (GO:0045006)5.81751928
8positive T cell selection (GO:0043368)5.73432272
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.65195784
10antigen processing and presentation of endogenous antigen (GO:0019883)5.59470288
11cellular response to type I interferon (GO:0071357)5.41695941
12type I interferon signaling pathway (GO:0060337)5.41695941
13response to type I interferon (GO:0034340)5.39894188
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.33756445
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.33756445
16response to interleukin-15 (GO:0070672)5.31239888
17positive regulation of interferon-alpha production (GO:0032727)5.25586136
18regulation of regulatory T cell differentiation (GO:0045589)4.99702847
19regulation of interferon-alpha production (GO:0032647)4.94584661
20positive regulation of natural killer cell mediated immunity (GO:0002717)4.94483193
21positive regulation of gamma-delta T cell activation (GO:0046645)4.92297074
22activated T cell proliferation (GO:0050798)4.90252973
23regulation of natural killer cell mediated immunity (GO:0002715)4.89134228
24regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.89134228
25positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.69233397
26neutrophil activation involved in immune response (GO:0002283)4.66020963
27thymic T cell selection (GO:0045061)4.64811146
28T cell selection (GO:0045058)4.64330820
29positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.50250838
30cellular response to exogenous dsRNA (GO:0071360)4.46435996
31cellular response to interferon-alpha (GO:0035457)4.38369298
32T cell migration (GO:0072678)4.38011464
33cellular response to interferon-beta (GO:0035458)4.36741499
34immunoglobulin mediated immune response (GO:0016064)4.33262355
35regulation of leukocyte mediated cytotoxicity (GO:0001910)4.29423518
36positive regulation by symbiont of host defense response (GO:0052509)4.17389055
37modulation by symbiont of host defense response (GO:0052031)4.17389055
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17389055
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17389055
40positive regulation by organism of defense response of other organism involved in symbiotic interact4.17389055
41modulation by symbiont of host immune response (GO:0052553)4.17389055
42positive regulation of tolerance induction (GO:0002645)4.16770278
43interferon-gamma-mediated signaling pathway (GO:0060333)4.14721218
44interferon-gamma production (GO:0032609)4.10260669
45positive regulation of cell killing (GO:0031343)4.10099740
46response to interferon-alpha (GO:0035455)4.10030404
47regulation of alpha-beta T cell proliferation (GO:0046640)4.08682044
48cellular response to zinc ion (GO:0071294)4.08666724
49regulation of T-helper 1 cell differentiation (GO:0045625)4.02827367
50defense response to protozoan (GO:0042832)4.02698642
51positive regulation of alpha-beta T cell proliferation (GO:0046641)4.01888974
52positive regulation of T cell mediated cytotoxicity (GO:0001916)4.01657450
53positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.99638314
54positive regulation of calcium-mediated signaling (GO:0050850)3.99213810
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.98869028
56regulation of B cell receptor signaling pathway (GO:0050855)3.98041504
57negative regulation of T cell apoptotic process (GO:0070233)3.97831783
58T cell receptor signaling pathway (GO:0050852)3.97657069
59regulation of cell killing (GO:0031341)3.96739321
60regulation of T cell mediated cytotoxicity (GO:0001914)3.94279490
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.92766070
62neutrophil activation (GO:0042119)3.91270976
63natural killer cell mediated cytotoxicity (GO:0042267)3.90575747
64natural killer cell mediated immunity (GO:0002228)3.90575747
65positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.90178116
66positive regulation of type 2 immune response (GO:0002830)3.89087446
67regulation of RIG-I signaling pathway (GO:0039535)3.88097555
68granulocyte activation (GO:0036230)3.87348192
69positive regulation of natural killer cell differentiation (GO:0032825)3.86812272
70regulation of interferon-beta biosynthetic process (GO:0045357)3.85944499
71antigen receptor-mediated signaling pathway (GO:0050851)3.84167632
72Arp2/3 complex-mediated actin nucleation (GO:0034314)3.82648316
73negative regulation of viral genome replication (GO:0045071)3.79995550
74regulation of activation of Janus kinase activity (GO:0010533)3.74363192
75regulation of tolerance induction (GO:0002643)3.73445314
76response to peptidoglycan (GO:0032494)3.72720985
77negative regulation by host of viral transcription (GO:0043922)3.71781398
78positive regulation of interferon-beta production (GO:0032728)3.70575531
79respiratory burst (GO:0045730)3.68071084
80B cell receptor signaling pathway (GO:0050853)3.65861396
81regulation of interleukin-2 biosynthetic process (GO:0045076)3.65710766
82positive regulation of interleukin-12 production (GO:0032735)3.65002457
83regulation of isotype switching to IgG isotypes (GO:0048302)3.64253481
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.59119131
85T cell costimulation (GO:0031295)3.57391597
86regulation of T cell receptor signaling pathway (GO:0050856)3.57265864
87negative thymic T cell selection (GO:0045060)3.56625124
88cellular response to virus (GO:0098586)3.55728359
89regulation of interleukin-12 biosynthetic process (GO:0045075)3.53633459
90lymphocyte costimulation (GO:0031294)3.53103199
91response to protozoan (GO:0001562)3.50782037
92negative regulation of T cell mediated immunity (GO:0002710)3.48814280
93negative T cell selection (GO:0043383)3.48605547
94response to interferon-beta (GO:0035456)3.47260895
95T-helper 1 type immune response (GO:0042088)3.47060419
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.46832462
97regulation of type I interferon-mediated signaling pathway (GO:0060338)3.46382759
98negative regulation of lymphocyte mediated immunity (GO:0002707)3.45918147
99positive regulation of antigen processing and presentation (GO:0002579)3.44487453
100B cell mediated immunity (GO:0019724)3.43829915
101positive regulation of T cell cytokine production (GO:0002726)3.43365467
102negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41779158
103negative regulation of cell killing (GO:0031342)3.41779158
104natural killer cell activation (GO:0030101)3.40997403
105leukocyte aggregation (GO:0070486)3.40867881
106macrophage activation involved in immune response (GO:0002281)3.37648675
107regulation of lymphocyte chemotaxis (GO:1901623)3.36120288
108dendritic cell chemotaxis (GO:0002407)3.35574669
109positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.34705175
110natural killer cell differentiation (GO:0001779)3.33945225
111regulation of dendritic cell antigen processing and presentation (GO:0002604)3.33706529
112lipopolysaccharide-mediated signaling pathway (GO:0031663)3.33466785
113regulation of gamma-delta T cell differentiation (GO:0045586)3.32926820
114cellular response to interferon-gamma (GO:0071346)3.32799265
115actin nucleation (GO:0045010)3.32404592
116negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.30405687
117positive regulation of defense response to virus by host (GO:0002230)3.29322470
118regulation of chronic inflammatory response (GO:0002676)3.29004607
119positive regulation of granulocyte differentiation (GO:0030854)3.27784301
120regulation of interferon-gamma biosynthetic process (GO:0045072)3.27522134
121regulation of gamma-delta T cell activation (GO:0046643)3.27241521
122positive regulation of T cell chemotaxis (GO:0010820)3.26604677
123regulation of T cell chemotaxis (GO:0010819)3.26604677
124cellular defense response (GO:0006968)3.25113970
125myeloid dendritic cell activation (GO:0001773)3.23580584
126myeloid dendritic cell differentiation (GO:0043011)3.23388232
127negative regulation of B cell proliferation (GO:0030889)3.22420154
128mast cell activation (GO:0045576)3.20879561
129positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.20386849
130myeloid cell activation involved in immune response (GO:0002275)3.20322325
131antigen processing and presentation via MHC class Ib (GO:0002475)3.19422305
132dendritic cell migration (GO:0036336)3.18868909
133positive regulation of interleukin-17 production (GO:0032740)3.18584724
134defense response to virus (GO:0051607)3.18507083
135regulation of B cell differentiation (GO:0045577)3.17749252
136regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.17482416
137positive regulation of T-helper cell differentiation (GO:0045624)3.15804708
138response to host immune response (GO:0052572)3.12206375
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.12206375
140negative regulation of leukocyte mediated immunity (GO:0002704)3.11756506
141NIK/NF-kappaB signaling (GO:0038061)3.11676985
142positive regulation of interleukin-2 production (GO:0032743)3.10322784
143regulation of calcium-mediated signaling (GO:0050848)3.08868765
144positive regulation of isotype switching (GO:0045830)3.07305883
145lymphocyte chemotaxis (GO:0048247)3.07175791
146pyrimidine nucleoside catabolic process (GO:0046135)3.05126455
147negative regulation of interleukin-17 production (GO:0032700)3.04910164
148positive regulation of lymphocyte mediated immunity (GO:0002708)3.04778809
149regulation of T cell tolerance induction (GO:0002664)3.04445670
150positive thymic T cell selection (GO:0045059)3.04165374
151regulation of antigen processing and presentation (GO:0002577)3.02117851
152cytolysis (GO:0019835)3.01777400
153leukocyte mediated cytotoxicity (GO:0001909)3.01621106
154regulation of defense response to virus by host (GO:0050691)3.01030034
155positive regulation of response to biotic stimulus (GO:0002833)3.00924931
156positive regulation of B cell differentiation (GO:0045579)3.00819373
157regulation of interleukin-12 production (GO:0032655)3.00633236
158regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.00424962
159positive regulation of lymphocyte migration (GO:2000403)3.00096537
160chemokine-mediated signaling pathway (GO:0070098)2.98676941
161positive regulation of interleukin-4 production (GO:0032753)2.98278529
162eosinophil chemotaxis (GO:0048245)2.97737349
163tolerance induction (GO:0002507)2.97177455
164positive regulation of T cell mediated immunity (GO:0002711)2.96349325
165regulation of T cell apoptotic process (GO:0070232)2.94117983
166lymphocyte migration (GO:0072676)2.91797931
167T cell differentiation (GO:0030217)2.91156687
168negative regulation of T cell receptor signaling pathway (GO:0050860)2.90459689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.66062302
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.95873640
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.93394971
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.81031167
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.75381604
6IRF8_27001747_Chip-Seq_BMDM_Mouse4.10685171
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.84960542
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.69498533
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.49638897
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.35239002
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.33217757
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.29189394
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.23011507
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22794500
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.58227470
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44044780
17* MYB_26560356_Chip-Seq_TH2_Human2.39731683
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.29450744
19RUNX_20019798_ChIP-Seq_JUKART_Human2.24074874
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22129675
21SPI1_23547873_ChIP-Seq_NB4_Human2.16456040
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.11156486
23MAF_26560356_Chip-Seq_TH1_Human2.10585638
24E2F7_22180533_ChIP-Seq_HELA_Human2.08199880
25* MYB_26560356_Chip-Seq_TH1_Human1.99942343
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92250524
27GATA1_22025678_ChIP-Seq_K562_Human1.85299286
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79546627
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75783539
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74845598
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69155994
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68582388
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68366729
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65529830
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.59747037
36VDR_21846776_ChIP-Seq_THP-1_Human1.58885765
37* PU_27001747_Chip-Seq_BMDM_Mouse1.57770368
38VDR_24763502_ChIP-Seq_THP-1_Human1.56983008
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56955347
40MYC_22102868_ChIP-Seq_BL_Human1.55162029
41GATA3_27048872_Chip-Seq_THYMUS_Human1.53212065
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.53002198
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50233676
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48510561
45* UTX_26944678_Chip-Seq_JUKART_Human1.47589970
46SCL_19346495_ChIP-Seq_HPC-7_Human1.46134284
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45654933
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44782943
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39116057
50SPI1_23127762_ChIP-Seq_K562_Human1.38768809
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38276365
52GATA3_26560356_Chip-Seq_TH2_Human1.37751029
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29897133
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28190501
55VDR_23849224_ChIP-Seq_CD4+_Human1.27818615
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23545000
57MAF_26560356_Chip-Seq_TH2_Human1.23119642
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22322912
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21934886
60* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21232636
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20463464
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19869491
63VDR_22108803_ChIP-Seq_LS180_Human1.18573186
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17665325
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16564052
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15818747
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.14993415
68ZNF274_21170338_ChIP-Seq_K562_Hela1.14937631
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13739838
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13412709
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11802206
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10083815
73VDR_24787735_ChIP-Seq_THP-1_Human1.10019281
74CIITA_25753668_ChIP-Seq_RAJI_Human1.08948281
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06521523
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.04006420
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03608254
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01284255
79SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99873784
80PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97984999
81EGR1_19032775_ChIP-ChIP_M12_Human0.97791342
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97522888
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97288016
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97102844
85ER_23166858_ChIP-Seq_MCF-7_Human0.97074376
86TCF7_22412390_ChIP-Seq_EML_Mouse0.95489653
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94484368
88IGF1R_20145208_ChIP-Seq_DFB_Human0.93804153
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93688798
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93340268
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.92988791
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92954540
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92592442
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91869100
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91730639
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91663943
97BCL6_27268052_Chip-Seq_Bcells_Human0.90637884
98NANOG_20526341_ChIP-Seq_ESCs_Human0.89269781
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87529154
100* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86522742
101GATA3_21878914_ChIP-Seq_MCF-7_Human0.86184731
102RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86177187
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85157694
104* EZH2_27294783_Chip-Seq_NPCs_Mouse0.85040952
105* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85030232
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84559065
107BCAT_22108803_ChIP-Seq_LS180_Human0.84213579
108* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83313061
109* FOXP3_21729870_ChIP-Seq_TREG_Human0.83281376
110HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82926813
111FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81588027
112FOXA1_25329375_ChIP-Seq_VCAP_Human0.81588027
113* TP53_22573176_ChIP-Seq_HFKS_Human0.81289280
114LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80982203
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.80511365
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79653896
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78608859
118GABP_17652178_ChIP-ChIP_JURKAT_Human0.78155769
119* TAF2_19829295_ChIP-Seq_ESCs_Human0.77082376
120GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76974227
121ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76853069
122FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76344651
123* CRX_20693478_ChIP-Seq_RETINA_Mouse0.76195195
124AR_20517297_ChIP-Seq_VCAP_Human0.75372899
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75316588
126EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75189939
127* P300_27268052_Chip-Seq_Bcells_Human0.72575963
128KDM2B_26808549_Chip-Seq_DND41_Human0.71762843
129GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71257707
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.68992242
131* SMRT_27268052_Chip-Seq_Bcells_Human0.68650278
132NOTCH1_21737748_ChIP-Seq_TLL_Human0.68103057
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.67905691
134GATA2_21666600_ChIP-Seq_HMVEC_Human0.64137467
135ELK3_25401928_ChIP-Seq_HUVEC_Human0.62411949
136ELK1_19687146_ChIP-ChIP_HELA_Human0.61045754
137IKZF1_21737484_ChIP-ChIP_HCT116_Human0.59749411
138KDM2B_26808549_Chip-Seq_SUP-B15_Human0.59336771
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.58791754
140GATA3_26560356_Chip-Seq_TH1_Human0.58229521
141ETS1_22383799_ChIP-Seq_G1ME_Mouse0.57677835
142CTCF_26484167_Chip-Seq_Bcells_Mouse0.57406336
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.57205268
144RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.51814574
145* SPI1_20517297_ChIP-Seq_HL60_Human0.51715830
146GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.50664422
147CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.49849696
148GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.48806662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.57370310
2MP0009785_altered_susceptibility_to4.13162161
3MP0005671_abnormal_response_to3.88539711
4MP0002148_abnormal_hypersensitivity_rea3.76566979
5MP0000685_abnormal_immune_system3.72086800
6MP0005387_immune_system_phenotype3.67931097
7MP0001790_abnormal_immune_system3.67931097
8MP0005000_abnormal_immune_tolerance3.56364183
9MP0001800_abnormal_humoral_immune3.43414413
10MP0003436_decreased_susceptibility_to3.40330473
11MP0005025_abnormal_response_to3.27123618
12MP0006082_CNS_inflammation3.14632270
13MP0002452_abnormal_antigen_presenting3.12156868
14MP0002723_abnormal_immune_serum3.03964559
15MP0003303_peritoneal_inflammation2.94968961
16MP0002419_abnormal_innate_immunity2.87780914
17MP0003724_increased_susceptibility_to2.83644619
18MP0001819_abnormal_immune_cell2.78197556
19MP0002420_abnormal_adaptive_immunity2.75211111
20MP0004510_myositis2.33632150
21MP0002166_altered_tumor_susceptibility2.32740173
22MP0002006_tumorigenesis2.30381338
23MP0003763_abnormal_thymus_physiology2.27432295
24MP0002398_abnormal_bone_marrow2.26223594
25MP0000716_abnormal_immune_system2.20851524
26MP0001845_abnormal_inflammatory_respons1.96507024
27MP0004947_skin_inflammation1.96264126
28MP0010155_abnormal_intestine_physiology1.95755411
29MP0002405_respiratory_system_inflammati1.94341779
30MP0001853_heart_inflammation1.86583359
31MP0009333_abnormal_splenocyte_physiolog1.77417993
32MP0000689_abnormal_spleen_morphology1.77029964
33MP0002429_abnormal_blood_cell1.75905147
34MP0004381_abnormal_hair_follicle1.75303240
35MP0005464_abnormal_platelet_physiology1.75049201
36MP0001533_abnormal_skeleton_physiology1.71228780
37MP0002722_abnormal_immune_system1.67653449
38MP0008469_abnormal_protein_level1.66805328
39MP0009764_decreased_sensitivity_to1.62813314
40MP0005075_abnormal_melanosome_morpholog1.59992254
41MP0003448_altered_tumor_morphology1.57985832
42MP0005310_abnormal_salivary_gland1.55933967
43MP0003787_abnormal_imprinting1.39604901
44MP0002638_abnormal_pupillary_reflex1.37404908
45MP0005058_abnormal_lysosome_morphology1.32298181
46MP0000858_altered_metastatic_potential1.30664071
47MP0000703_abnormal_thymus_morphology1.24870556
48MP0002009_preneoplasia1.20937786
49MP0001545_abnormal_hematopoietic_system1.19478933
50MP0005397_hematopoietic_system_phenotyp1.19478933
51MP0003300_gastrointestinal_ulcer1.10973528
52MP0003172_abnormal_lysosome_physiology1.08534296
53MP0004808_abnormal_hematopoietic_stem1.07939624
54MP0001873_stomach_inflammation1.07746813
55MP0002998_abnormal_bone_remodeling1.07259338
56MP0001919_abnormal_reproductive_system1.05745430
57MP0010307_abnormal_tumor_latency1.04092394
58MP0002396_abnormal_hematopoietic_system1.03800469
59MP0008877_abnormal_DNA_methylation1.02980603
60MP0002102_abnormal_ear_morphology1.01449614
61MP0008057_abnormal_DNA_replication1.01359668
62MP0002933_joint_inflammation1.00444109
63MP0009278_abnormal_bone_marrow1.00260317
64MP0002138_abnormal_hepatobiliary_system1.00007173
65MP0005645_abnormal_hypothalamus_physiol0.99876154
66MP0003075_altered_response_to0.99183571
67MP0009763_increased_sensitivity_to0.98575297
68MP0003866_abnormal_defecation0.98569476
69MP0003646_muscle_fatigue0.97692135
70MP0000343_altered_response_to0.95487944
71MP0001986_abnormal_taste_sensitivity0.94028978
72MP0000372_irregular_coat_pigmentation0.93086581
73MP0000569_abnormal_digit_pigmentation0.92128517
74MP0005166_decreased_susceptibility_to0.87120840
75MP0003191_abnormal_cellular_cholesterol0.86799938
76MP0004142_abnormal_muscle_tone0.83875287
77MP0002277_abnormal_respiratory_mucosa0.82507692
78MP0004130_abnormal_muscle_cell0.82364896
79MP0004782_abnormal_surfactant_physiolog0.82018093
80MP0001348_abnormal_lacrimal_gland0.79239268
81MP0002163_abnormal_gland_morphology0.78391885
82MP0003045_fibrosis0.77262879
83MP0003186_abnormal_redox_activity0.76594891
84MP0002019_abnormal_tumor_incidence0.76011784
85MP0008872_abnormal_physiological_respon0.75351253
86MP0004883_abnormal_blood_vessel0.74163728
87MP0000490_abnormal_crypts_of0.71022520
88MP0003183_abnormal_peptide_metabolism0.69812059
89MP0000604_amyloidosis0.69358227
90MP0005390_skeleton_phenotype0.69010715
91MP0001905_abnormal_dopamine_level0.68866508
92MP0005174_abnormal_tail_pigmentation0.67989276
93MP0003091_abnormal_cell_migration0.67760883
94MP0002136_abnormal_kidney_physiology0.67638473
95MP0010352_gastrointestinal_tract_polyps0.66811150
96MP0001501_abnormal_sleep_pattern0.66219367
97MP0005164_abnormal_response_to0.64430673
98MP0005389_reproductive_system_phenotype0.63056594
99MP0000249_abnormal_blood_vessel0.61897794
100MP0005076_abnormal_cell_differentiation0.61496192
101MP0003453_abnormal_keratinocyte_physiol0.60645794
102MP0003786_premature_aging0.60366590
103MP0003690_abnormal_glial_cell0.59453645
104MP0005551_abnormal_eye_electrophysiolog0.59178193
105MP0008961_abnormal_basal_metabolism0.58485124
106MP0009765_abnormal_xenobiotic_induced0.57254555
107MP0000465_gastrointestinal_hemorrhage0.56872011
108MP0002693_abnormal_pancreas_physiology0.55244579
109MP0001851_eye_inflammation0.54561174
110MP0003252_abnormal_bile_duct0.53324939
111MP0001765_abnormal_ion_homeostasis0.53198376
112MP0001764_abnormal_homeostasis0.52613222
113MP0009840_abnormal_foam_cell0.52164894
114MP0003566_abnormal_cell_adhesion0.50190465
115MP0003828_pulmonary_edema0.49524806
116MP0001663_abnormal_digestive_system0.47996915
117MP0001968_abnormal_touch/_nociception0.47668783
118MP0002928_abnormal_bile_duct0.47552219
119MP0004742_abnormal_vestibular_system0.46542763
120MP0003795_abnormal_bone_structure0.45886515
121MP0000015_abnormal_ear_pigmentation0.45668039
122MP0004043_abnormal_pH_regulation0.45094396
123MP0002095_abnormal_skin_pigmentation0.44665551
124MP0005379_endocrine/exocrine_gland_phen0.43748382
125MP0000371_diluted_coat_color0.42864264
126MP0001881_abnormal_mammary_gland0.40662982
127MP0008873_increased_physiological_sensi0.39910666
128MP0001915_intracranial_hemorrhage0.39704707
129MP0002132_abnormal_respiratory_system0.38545021
130MP0005584_abnormal_enzyme/coenzyme_acti0.37359856

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.21971917
2Recurrent bacterial skin infections (HP:0005406)5.88359856
3Eczematoid dermatitis (HP:0000976)5.80210072
4Elevated erythrocyte sedimentation rate (HP:0003565)5.42371685
5Increased IgM level (HP:0003496)4.90873458
6Autoimmune thrombocytopenia (HP:0001973)4.89545368
7Recurrent viral infections (HP:0004429)4.81520792
8Recurrent fungal infections (HP:0002841)4.46876860
9Mediastinal lymphadenopathy (HP:0100721)4.46436433
10Vasculitis (HP:0002633)4.44328847
11Recurrent gram-negative bacterial infections (HP:0005420)4.39187971
12Chronic otitis media (HP:0000389)4.33852129
13Recurrent bronchitis (HP:0002837)4.25679949
14Agammaglobulinemia (HP:0004432)4.21335893
15Recurrent skin infections (HP:0001581)4.13338673
16Hypoproteinemia (HP:0003075)4.11587333
17Myositis (HP:0100614)4.07838744
18Abnormality of T cell number (HP:0011839)4.05774686
19Recurrent cutaneous fungal infections (HP:0011370)3.85798590
20Chronic mucocutaneous candidiasis (HP:0002728)3.85798590
21Cellulitis (HP:0100658)3.85375601
22T lymphocytopenia (HP:0005403)3.80929235
23Abnormality of macrophages (HP:0004311)3.80129365
24Basal ganglia calcification (HP:0002135)3.67658482
25Stomatitis (HP:0010280)3.65708117
26Meningitis (HP:0001287)3.62013756
27Hypergammaglobulinemia (HP:0010702)3.52785452
28Optic neuritis (HP:0100653)3.46697223
29Retrobulbar optic neuritis (HP:0100654)3.46697223
30Gastrointestinal infarctions (HP:0005244)3.43069870
31Chronic obstructive pulmonary disease (HP:0006510)3.40317571
32Obstructive lung disease (HP:0006536)3.40317571
33Orchitis (HP:0100796)3.39853485
34Abnormality of T cells (HP:0002843)3.35517273
35Pustule (HP:0200039)3.25132740
36Gingivitis (HP:0000230)3.23323396
37Colitis (HP:0002583)3.23299392
38IgG deficiency (HP:0004315)3.18233536
39Nasal polyposis (HP:0100582)3.15461783
40Interstitial pulmonary disease (HP:0006530)3.13311102
41Chronic sinusitis (HP:0011109)3.12004603
42Abnormal delayed hypersensitivity skin test (HP:0002963)3.11183985
43Abnormality of cells of the lymphoid lineage (HP:0012140)3.10787754
44Lymphopenia (HP:0001888)3.08761665
45Thyroiditis (HP:0100646)3.06214807
46Eosinophilia (HP:0001880)3.05850611
47Periodontitis (HP:0000704)3.04966028
48Gastrointestinal stroma tumor (HP:0100723)3.02013859
49Aplastic anemia (HP:0001915)3.00106967
50Recurrent pneumonia (HP:0006532)2.99419914
51Inflammation of the large intestine (HP:0002037)2.96833164
52Autoimmune hemolytic anemia (HP:0001890)2.95713599
53Panhypogammaglobulinemia (HP:0003139)2.94654098
54Leukocytosis (HP:0001974)2.93679824
55Pulmonary infiltrates (HP:0002113)2.89338116
56IgA deficiency (HP:0002720)2.87844439
57Abnormality of T cell physiology (HP:0011840)2.87609534
58Recurrent sinusitis (HP:0011108)2.86280557
59Gastrointestinal inflammation (HP:0004386)2.85070940
60Combined immunodeficiency (HP:0005387)2.83221531
61Recurrent lower respiratory tract infections (HP:0002783)2.82228863
62Hemiplegia (HP:0002301)2.80440307
63Systemic lupus erythematosus (HP:0002725)2.78148178
64Severe combined immunodeficiency (HP:0004430)2.76358610
65Abnormality of eosinophils (HP:0001879)2.72472655
66IgM deficiency (HP:0002850)2.70589547
67Osteomyelitis (HP:0002754)2.70403998
68Abnormality of the nasal mucosa (HP:0000433)2.66643353
69Hemoptysis (HP:0002105)2.66272070
70Granulocytopenia (HP:0001913)2.60744544
71Thrombocytosis (HP:0001894)2.58114500
72Congenital stationary night blindness (HP:0007642)2.54202267
73Porencephaly (HP:0002132)2.49156124
74Emphysema (HP:0002097)2.47936466
75Pulmonary embolism (HP:0002204)2.46131962
76Petechiae (HP:0000967)2.42966794
77Arterial thrombosis (HP:0004420)2.42932453
78Vacuolated lymphocytes (HP:0001922)2.42677117
79Chronic diarrhea (HP:0002028)2.41110773
80Verrucae (HP:0200043)2.40742336
81Papilloma (HP:0012740)2.40742336
82Abnormality of B cell number (HP:0010975)2.40656600
83B lymphocytopenia (HP:0010976)2.40656600
84Sepsis (HP:0100806)2.40179181
85Hypochromic anemia (HP:0001931)2.37819379
86Gingival bleeding (HP:0000225)2.37253174
87Gangrene (HP:0100758)2.35930473
88Skin ulcer (HP:0200042)2.32605614
89Prostate neoplasm (HP:0100787)2.32342842
90Acute hepatic failure (HP:0006554)2.29834542
91Encephalitis (HP:0002383)2.29700460
92Hematochezia (HP:0002573)2.29355254
93Bronchitis (HP:0012387)2.28167430
94Urticaria (HP:0001025)2.26687790
95Chest pain (HP:0100749)2.25476298
96Joint swelling (HP:0001386)2.25334219
97Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25185780
98Keratoconjunctivitis sicca (HP:0001097)2.24742108
99Abnormality of the pleura (HP:0002103)2.20256238
100Arthralgia (HP:0002829)2.18146515
101Stomach cancer (HP:0012126)2.15536608
102Spontaneous hematomas (HP:0007420)2.15020266
103Abnormality of the prostate (HP:0008775)2.14032169
104Increased IgE level (HP:0003212)2.13613150
105Thick nail (HP:0001805)2.13185922
106Hypochromic microcytic anemia (HP:0004840)2.12266437
107Poor head control (HP:0002421)2.11479378
108Abnormal rod and cone electroretinograms (HP:0008323)2.11302379
109Lymphoma (HP:0002665)2.09147349
110Cleft eyelid (HP:0000625)2.05753178
111Hypoplasia of the thymus (HP:0000778)2.05203247
112Keratoconjunctivitis (HP:0001096)2.03873493
113Neutropenia (HP:0001875)2.02677706
114Hypoalbuminemia (HP:0003073)2.00855695
115Abnormal albumin level (HP:0012116)2.00855695
116Anorexia (HP:0002039)1.94161891
117Alveolar cell carcinoma (HP:0006519)1.93337386
118Epistaxis (HP:0000421)1.92849070
119Pancreatic cysts (HP:0001737)1.92028374
1203-Methylglutaconic aciduria (HP:0003535)1.89723659
121Microcytic anemia (HP:0001935)1.89610730
122Polyneuropathy (HP:0001271)1.85251909
123Keratitis (HP:0000491)1.81256465
124Skin rash (HP:0000988)1.81087625
125Attenuation of retinal blood vessels (HP:0007843)1.80789176
126Neoplasm of the tracheobronchial system (HP:0100552)1.77088561
127Recurrent otitis media (HP:0000403)1.76346232
128Ureteral stenosis (HP:0000071)1.73827694
129Ureteral obstruction (HP:0006000)1.72406221
130Prolonged bleeding time (HP:0003010)1.71185073
131Glomerulopathy (HP:0100820)1.70051125
132Abnormality of the renal cortex (HP:0011035)1.68856867
133Abnormality of male internal genitalia (HP:0000022)1.66577970
134Amyotrophic lateral sclerosis (HP:0007354)1.64688139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.39480614
2TYK24.11684865
3MAP4K13.72395243
4BLK3.32673280
5JAK33.31290098
6TBK13.27817259
7RIPK43.16869628
8IKBKE3.15973403
9IRAK43.05312973
10JAK12.81356426
11TXK2.77119035
12PBK2.76164838
13MAP3K132.49348473
14IKBKB2.18797863
15FGFR42.09100462
16KIT2.07458795
17SYK2.03329829
18FRK1.95798763
19ZAP701.90558157
20CSK1.77967867
21MST41.69550492
22MAP3K101.65970730
23ERN11.65205660
24FGFR31.65132616
25IRAK31.61449196
26STK101.57209966
27BTK1.56298791
28CAMKK21.54804440
29PIM21.53748856
30GRK61.47816198
31HCK1.38707671
32LCK1.38533025
33STK41.32016569
34LYN1.31289759
35CHUK1.30001197
36CSF1R1.29989560
37PIM11.24787239
38SIK31.23600415
39TEC1.16594702
40MARK31.14123890
41BMPR21.11062822
42ITK1.10208975
43NEK91.09027644
44ZAK1.08904073
45NUAK11.05758159
46RPS6KA41.02375170
47MAP3K111.00475713
48SIK20.96306753
49JAK20.95885866
50PRKCQ0.95418535
51LRRK20.93375557
52MATK0.87636638
53FES0.87216326
54NLK0.86942115
55PIK3CG0.86198514
56MAP2K60.84510398
57IRAK10.82001840
58MAPKAPK30.81070688
59TAOK30.79797497
60GRK10.78227567
61NME20.77962703
62EPHB10.77845951
63TYRO30.76887153
64BCKDK0.75574212
65EPHA30.75391274
66EIF2AK20.74727555
67CAMKK10.73968357
68ARAF0.69333796
69CDK120.69022438
70ACVR1B0.66685624
71TRPM70.66627368
72CLK10.64743089
73VRK10.61745714
74ADRBK10.60357281
75PIK3CA0.60071842
76PRKCD0.59113171
77WNK40.57381504
78IRAK20.55416955
79ABL10.53396031
80BMX0.53383178
81FGR0.51223114
82PASK0.50976885
83MAP3K50.50299929
84PINK10.49005625
85MUSK0.48931467
86CDK40.48228523
87GRK50.46710315
88BMPR1B0.43049096
89YES10.41172322
90EGFR0.38586118
91STK110.37325713
92PTK2B0.36080650
93CDK190.36031714
94OXSR10.34411074
95MAPK110.33655338
96ADRBK20.33391381
97MAPK130.33022426
98RPS6KA50.32779111
99MAPKAPK20.31455754
100TLK10.30949456
101TGFBR20.30737943
102PDK10.30464291
103FYN0.30272287
104KDR0.29553509
105ABL20.29345842
106FLT30.28670164
107INSR0.27829984
108DAPK20.27631650
109INSRR0.26945134
110TESK10.26508467
111PKN10.23568972
112EIF2AK10.23544559
113PAK30.23272972
114EIF2AK30.23047637
115HIPK20.22890912
116DYRK1B0.22707707
117ATR0.22534260
118PRKCH0.22133083
119GRK70.21670394
120MAP3K120.21097910
121MAP3K80.19844507
122MAPK40.19511075
123CDK30.18883900
124PRKCA0.18482816
125SGK20.18457544
126MAP4K20.18062499
127AKT30.17995705
128MAP3K70.17317577
129PRKACA0.16620976
130ALK0.15762961
131STK30.15746972
132CDK60.15437932
133TESK20.14820152
134MAPK30.14501869
135IGF1R0.13817136
136RPS6KA60.13783882
137TNK20.10834181

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.56249940
2Graft-versus-host disease_Homo sapiens_hsa053323.46738382
3Primary immunodeficiency_Homo sapiens_hsa053403.34212755
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.09605058
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.00771479
6Leishmaniasis_Homo sapiens_hsa051402.89832157
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.84992355
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.82901101
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.73014802
10Measles_Homo sapiens_hsa051622.72010315
11Influenza A_Homo sapiens_hsa051642.15921061
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15009106
13B cell receptor signaling pathway_Homo sapiens_hsa046622.14937746
14Herpes simplex infection_Homo sapiens_hsa051682.13233855
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.12205858
16Osteoclast differentiation_Homo sapiens_hsa043802.12155437
17Type I diabetes mellitus_Homo sapiens_hsa049402.05976909
18Antigen processing and presentation_Homo sapiens_hsa046121.98707415
19Autoimmune thyroid disease_Homo sapiens_hsa053201.96603593
20Staphylococcus aureus infection_Homo sapiens_hsa051501.94950331
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.90675497
22Legionellosis_Homo sapiens_hsa051341.88279493
23Pertussis_Homo sapiens_hsa051331.84978329
24Malaria_Homo sapiens_hsa051441.77700335
25Tuberculosis_Homo sapiens_hsa051521.77616185
26Viral myocarditis_Homo sapiens_hsa054161.71220750
27Asthma_Homo sapiens_hsa053101.69815467
28TNF signaling pathway_Homo sapiens_hsa046681.67292724
29Hematopoietic cell lineage_Homo sapiens_hsa046401.65711815
30Toxoplasmosis_Homo sapiens_hsa051451.65375366
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.55662814
32Chemokine signaling pathway_Homo sapiens_hsa040621.54837545
33African trypanosomiasis_Homo sapiens_hsa051431.54270991
34Rheumatoid arthritis_Homo sapiens_hsa053231.52280654
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42396629
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41158290
37T cell receptor signaling pathway_Homo sapiens_hsa046601.39655247
38Salmonella infection_Homo sapiens_hsa051321.31773821
39Apoptosis_Homo sapiens_hsa042101.30570473
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29589096
41Hepatitis B_Homo sapiens_hsa051611.25927485
42Shigellosis_Homo sapiens_hsa051311.16902460
43Hepatitis C_Homo sapiens_hsa051601.13718245
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98944261
45Phototransduction_Homo sapiens_hsa047440.96978556
46Phagosome_Homo sapiens_hsa041450.88910777
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.88436795
48Linoleic acid metabolism_Homo sapiens_hsa005910.88292997
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86718646
50Lysosome_Homo sapiens_hsa041420.84461723
51Epstein-Barr virus infection_Homo sapiens_hsa051690.83600281
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83363229
53Regulation of autophagy_Homo sapiens_hsa041400.80125152
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78482443
55Acute myeloid leukemia_Homo sapiens_hsa052210.75647385
56Nitrogen metabolism_Homo sapiens_hsa009100.72297882
57Oxidative phosphorylation_Homo sapiens_hsa001900.69069497
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66411136
59Viral carcinogenesis_Homo sapiens_hsa052030.64132662
60Prolactin signaling pathway_Homo sapiens_hsa049170.62863978
61Proteasome_Homo sapiens_hsa030500.62275507
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61998590
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61968987
64Other glycan degradation_Homo sapiens_hsa005110.60906254
65Pancreatic cancer_Homo sapiens_hsa052120.60840424
66Platelet activation_Homo sapiens_hsa046110.59894953
67Chronic myeloid leukemia_Homo sapiens_hsa052200.57025474
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55679163
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54744954
70Parkinsons disease_Homo sapiens_hsa050120.54534607
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54072240
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51620903
73HTLV-I infection_Homo sapiens_hsa051660.50417065
74Systemic lupus erythematosus_Homo sapiens_hsa053220.48684527
75Amoebiasis_Homo sapiens_hsa051460.47613603
76Small cell lung cancer_Homo sapiens_hsa052220.46602266
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46439469
78Olfactory transduction_Homo sapiens_hsa047400.45330417
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44934277
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44502094
81Non-homologous end-joining_Homo sapiens_hsa034500.43806462
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.42756248
83p53 signaling pathway_Homo sapiens_hsa041150.40630181
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39388313
85Morphine addiction_Homo sapiens_hsa050320.39220125
86ABC transporters_Homo sapiens_hsa020100.38401809
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38317974
88RNA polymerase_Homo sapiens_hsa030200.37593419
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.36754409
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34742128
91Ether lipid metabolism_Homo sapiens_hsa005650.33217073
92HIF-1 signaling pathway_Homo sapiens_hsa040660.31783871
93Peroxisome_Homo sapiens_hsa041460.31741488
94Arachidonic acid metabolism_Homo sapiens_hsa005900.30628523
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30520254
96Notch signaling pathway_Homo sapiens_hsa043300.29421275
97Prion diseases_Homo sapiens_hsa050200.29172244
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28942426
99Alzheimers disease_Homo sapiens_hsa050100.28244828
100Collecting duct acid secretion_Homo sapiens_hsa049660.27898482
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27690947
102RNA degradation_Homo sapiens_hsa030180.27581184
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.27428096
104Base excision repair_Homo sapiens_hsa034100.25974242
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.24696937
106VEGF signaling pathway_Homo sapiens_hsa043700.23634302
107FoxO signaling pathway_Homo sapiens_hsa040680.22099919
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.19640450
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18901152
110Non-small cell lung cancer_Homo sapiens_hsa052230.18473537
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18244898
112Dorso-ventral axis formation_Homo sapiens_hsa043200.18167854
113Ras signaling pathway_Homo sapiens_hsa040140.17974506
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14547748
115Caffeine metabolism_Homo sapiens_hsa002320.14138521
116MicroRNAs in cancer_Homo sapiens_hsa052060.13865766
117Taste transduction_Homo sapiens_hsa047420.11836616
118Type II diabetes mellitus_Homo sapiens_hsa049300.11432660
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11288870
120Insulin resistance_Homo sapiens_hsa049310.11097288
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10724343
122Calcium signaling pathway_Homo sapiens_hsa040200.10091577
123Endocytosis_Homo sapiens_hsa041440.09792061
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09613622
125Glycerolipid metabolism_Homo sapiens_hsa005610.08768197
126Colorectal cancer_Homo sapiens_hsa052100.08487025
127Proteoglycans in cancer_Homo sapiens_hsa052050.07957048
128MAPK signaling pathway_Homo sapiens_hsa040100.07657874
129DNA replication_Homo sapiens_hsa030300.07594613
130Inositol phosphate metabolism_Homo sapiens_hsa005620.06771362

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