PYM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.28372072
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.73309683
3negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.59821754
4protein localization to kinetochore (GO:0034501)4.50187521
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.34131508
6establishment of integrated proviral latency (GO:0075713)4.29842991
7chaperone-mediated protein transport (GO:0072321)4.28468472
8regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.24228871
9positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.23352249
10negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.20544896
11negative regulation of ligase activity (GO:0051352)4.20544896
12DNA unwinding involved in DNA replication (GO:0006268)4.19174303
13regulation of cellular amino acid metabolic process (GO:0006521)4.09845404
14formation of translation preinitiation complex (GO:0001731)4.08876754
15DNA strand elongation involved in DNA replication (GO:0006271)3.98303137
16ATP synthesis coupled proton transport (GO:0015986)3.95793444
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.95793444
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.93597832
19DNA replication initiation (GO:0006270)3.93537706
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.83528193
21DNA strand elongation (GO:0022616)3.78407955
22signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.76102710
23signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.76102710
24signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.76102710
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.75764678
26intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.75764678
27regulation of mitochondrial translation (GO:0070129)3.75127730
28establishment of viral latency (GO:0019043)3.74969047
29mitotic nuclear envelope disassembly (GO:0007077)3.73557369
30DNA replication-dependent nucleosome organization (GO:0034723)3.71942898
31DNA replication-dependent nucleosome assembly (GO:0006335)3.71942898
32mitotic sister chromatid segregation (GO:0000070)3.70583599
33DNA deamination (GO:0045006)3.69851372
34protein localization to chromosome, centromeric region (GO:0071459)3.68767568
35telomere maintenance via semi-conservative replication (GO:0032201)3.67958849
36folic acid-containing compound biosynthetic process (GO:0009396)3.67419088
37protein neddylation (GO:0045116)3.66907123
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.63267100
39signal transduction involved in DNA damage checkpoint (GO:0072422)3.63267100
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.59279396
41signal transduction involved in cell cycle checkpoint (GO:0072395)3.55929587
42respiratory chain complex IV assembly (GO:0008535)3.54416234
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.52913551
44rRNA modification (GO:0000154)3.52677573
45ribosome biogenesis (GO:0042254)3.52493257
46nuclear pore organization (GO:0006999)3.49771713
47nucleobase biosynthetic process (GO:0046112)3.48201538
48positive regulation of ligase activity (GO:0051351)3.47896274
49nuclear pore complex assembly (GO:0051292)3.46781262
50regulation of gene silencing by RNA (GO:0060966)3.43311370
51regulation of posttranscriptional gene silencing (GO:0060147)3.43311370
52regulation of gene silencing by miRNA (GO:0060964)3.43311370
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.43086476
54somatic diversification of immune receptors via somatic mutation (GO:0002566)3.43086476
55DNA replication checkpoint (GO:0000076)3.43034338
56membrane disassembly (GO:0030397)3.42465700
57nuclear envelope disassembly (GO:0051081)3.42465700
58IMP biosynthetic process (GO:0006188)3.40831102
59cytochrome complex assembly (GO:0017004)3.37590902
60ribosomal small subunit assembly (GO:0000028)3.37439211
61antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.36558597
62heterochromatin organization (GO:0070828)3.36093938
63dosage compensation (GO:0007549)3.35988527
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35623830
65DNA catabolic process, exonucleolytic (GO:0000738)3.35005499
66DNA duplex unwinding (GO:0032508)3.34301966
67respiratory electron transport chain (GO:0022904)3.33199974
68DNA geometric change (GO:0032392)3.31652136
69mitotic metaphase plate congression (GO:0007080)3.31010875
70sister chromatid segregation (GO:0000819)3.30315513
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.29056615
72DNA ligation (GO:0006266)3.26471176
73electron transport chain (GO:0022900)3.24566992
74regulation of ubiquitin-protein transferase activity (GO:0051438)3.24209362
75chromatin remodeling at centromere (GO:0031055)3.22626197
76telomere maintenance via recombination (GO:0000722)3.21141213
77protein targeting to mitochondrion (GO:0006626)3.21109904
78CENP-A containing nucleosome assembly (GO:0034080)3.20856438
79termination of RNA polymerase III transcription (GO:0006386)3.19707684
80transcription elongation from RNA polymerase III promoter (GO:0006385)3.19707684
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17588971
82protein complex biogenesis (GO:0070271)3.16780275
83regulation of ligase activity (GO:0051340)3.16167175
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.14756034
85regulation of translational fidelity (GO:0006450)3.13079514
86mitochondrial respiratory chain complex assembly (GO:0033108)3.12131655
87protein deneddylation (GO:0000338)3.11716091
88deoxyribonucleotide catabolic process (GO:0009264)3.11068369
89mitotic chromosome condensation (GO:0007076)3.10950845
90purine nucleobase biosynthetic process (GO:0009113)3.10461398
91ribonucleoprotein complex biogenesis (GO:0022613)3.10324486
92maturation of SSU-rRNA (GO:0030490)3.08503249
93regulation of cellular amine metabolic process (GO:0033238)3.08233856
94deoxyribose phosphate catabolic process (GO:0046386)3.07892573
95L-serine metabolic process (GO:0006563)3.07359501
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.07287722
97viral transcription (GO:0019083)3.06494445
98mitotic recombination (GO:0006312)3.06488096
99telomere maintenance via telomere lengthening (GO:0010833)3.02980023
100pre-miRNA processing (GO:0031054)3.02795166
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01920150
102purine deoxyribonucleotide catabolic process (GO:0009155)3.01138662
103inner mitochondrial membrane organization (GO:0007007)3.01087448
104regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00664000
105regulation of mitotic spindle checkpoint (GO:1903504)3.00664000
106negative regulation of protein ubiquitination (GO:0031397)3.00635823
107negative regulation of RNA splicing (GO:0033119)2.99025872
108establishment of protein localization to mitochondrion (GO:0072655)2.98804124
109translational termination (GO:0006415)2.97024439
110IMP metabolic process (GO:0046040)2.96743659
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96517106
112oxidative phosphorylation (GO:0006119)2.96426827
113pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96257092
114translational initiation (GO:0006413)2.92786289
115protein localization to mitochondrion (GO:0070585)2.90864477
116translation (GO:0006412)2.89838327
117negative regulation of histone methylation (GO:0031061)2.89094817
118deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89018229
119rRNA processing (GO:0006364)2.88596805
120cullin deneddylation (GO:0010388)2.88259005
121histone H4-K12 acetylation (GO:0043983)2.87925730
122positive regulation of cell cycle arrest (GO:0071158)2.87907272
123regulation of spindle organization (GO:0090224)2.87508610
124replication fork processing (GO:0031297)2.85156512
125rRNA methylation (GO:0031167)2.84102577
126ribosomal small subunit biogenesis (GO:0042274)2.84098778
127deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.83647779
128regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.83524534
129chromatin assembly (GO:0031497)2.83244681
130negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.82872259
131translational elongation (GO:0006414)2.82750886
132nucleotide-excision repair, DNA gap filling (GO:0006297)2.82681931
133DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.81430864
134nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80845211
135positive regulation of chromosome segregation (GO:0051984)2.80344423
136pore complex assembly (GO:0046931)2.79728752
137rRNA metabolic process (GO:0016072)2.79234942
138spliceosomal tri-snRNP complex assembly (GO:0000244)2.79226302
139peptidyl-arginine omega-N-methylation (GO:0035247)2.77819735
140DNA double-strand break processing (GO:0000729)2.76479914
141regulation of translational termination (GO:0006449)2.76236921
142mitotic G1 DNA damage checkpoint (GO:0031571)2.75754159
143ribosome assembly (GO:0042255)2.75620873
144metaphase plate congression (GO:0051310)2.75229438
145regulation of histone H3-K9 methylation (GO:0051570)2.75030559
146negative regulation of mRNA processing (GO:0050686)2.74966591
147base-excision repair (GO:0006284)2.73905267
148DNA damage response, detection of DNA damage (GO:0042769)2.73721449
149mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73161488
150mitochondrial respiratory chain complex I assembly (GO:0032981)2.73161488
151NADH dehydrogenase complex assembly (GO:0010257)2.73161488
152nuclear envelope organization (GO:0006998)2.72672349
153maturation of 5.8S rRNA (GO:0000460)2.72296662
154RNA splicing, via transesterification reactions (GO:0000375)2.71912891
155mRNA splicing, via spliceosome (GO:0000398)2.71268669
156RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.71268669
157cellular component biogenesis (GO:0044085)2.70348716
158regulation of translation in response to stress (GO:0043555)2.68747753
159spliceosomal snRNP assembly (GO:0000387)2.68593219
160regulation of double-strand break repair via homologous recombination (GO:0010569)2.68480265
161protein maturation by protein folding (GO:0022417)2.68470310
162DNA conformation change (GO:0071103)2.68399832
163GDP-mannose metabolic process (GO:0019673)2.68279688
164regulation of nuclear cell cycle DNA replication (GO:0033262)2.68104734
165base-excision repair, AP site formation (GO:0006285)2.67364899
166antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.66936634
167transcription-coupled nucleotide-excision repair (GO:0006283)2.66044367
168chromatin assembly or disassembly (GO:0006333)2.65260657
169establishment of chromosome localization (GO:0051303)2.63642664
170termination of RNA polymerase II transcription (GO:0006369)2.61463863
171mitochondrial DNA metabolic process (GO:0032042)2.61301970
172DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.60222877
173intracellular estrogen receptor signaling pathway (GO:0030520)2.59481998
174regulation of telomere maintenance via telomerase (GO:0032210)2.59080162
175histone arginine methylation (GO:0034969)2.59027974
176kinetochore organization (GO:0051383)2.58418664
177ribosomal large subunit biogenesis (GO:0042273)2.57417672
178protein localization to chromosome (GO:0034502)2.57245688
179regulation of gene silencing (GO:0060968)2.57085967
180pseudouridine synthesis (GO:0001522)2.54209725
181negative regulation of chromosome segregation (GO:0051985)2.54049013
182telomere organization (GO:0032200)2.53966783
183DNA damage response, signal transduction resulting in transcription (GO:0042772)2.53261536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.22350678
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.86261444
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.39091028
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37250066
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21510038
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89853593
7MYC_22102868_ChIP-Seq_BL_Human2.77183017
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68536482
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58992350
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32041929
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29454272
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.24701984
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23010819
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19085866
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.10495641
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08341527
17XRN2_22483619_ChIP-Seq_HELA_Human2.00091758
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98612630
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.97972064
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.94458268
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92626510
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90102680
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86944990
24ELK1_19687146_ChIP-ChIP_HELA_Human1.86332553
25VDR_21846776_ChIP-Seq_THP-1_Human1.85484252
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79037349
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76251423
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76205789
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71576129
30CIITA_25753668_ChIP-Seq_RAJI_Human1.67798992
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.67192859
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67185298
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66729681
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66606271
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65994234
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65770646
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64749806
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63924639
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63032612
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62404355
41VDR_23849224_ChIP-Seq_CD4+_Human1.61916235
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59124423
43FOXP3_21729870_ChIP-Seq_TREG_Human1.57700264
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57602563
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.57470039
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55894147
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53912387
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49805421
49GABP_19822575_ChIP-Seq_HepG2_Human1.49651437
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48789906
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47740950
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46095901
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45659794
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45659794
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45659794
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41924917
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40836847
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40505835
59KDM5A_27292631_Chip-Seq_BREAST_Human1.39304181
60DCP1A_22483619_ChIP-Seq_HELA_Human1.38604208
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38077807
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37262085
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35336241
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33354853
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.32626820
66AR_21909140_ChIP-Seq_LNCAP_Human1.31886738
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31638866
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31609017
69TTF2_22483619_ChIP-Seq_HELA_Human1.30699721
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28580277
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26871931
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24375308
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23670361
74NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.22343729
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21855316
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21605099
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.21421392
78MAF_26560356_Chip-Seq_TH1_Human1.20627367
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20302301
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18591025
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17248259
82UTX_26944678_Chip-Seq_JUKART_Human1.16377424
83TCF7_22412390_ChIP-Seq_EML_Mouse1.15115218
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14288141
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13992576
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13618657
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11340150
88TFEB_21752829_ChIP-Seq_HELA_Human1.09858567
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.09343727
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09301362
91TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09285482
92MYC_18940864_ChIP-ChIP_HL60_Human1.09085487
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.08321927
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.07668026
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05406394
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05312355
97HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03969292
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02740365
99MAF_26560356_Chip-Seq_TH2_Human1.01751669
100SPI1_23547873_ChIP-Seq_NB4_Human1.00984878
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00802188
102ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00753313
103IRF8_21731497_ChIP-ChIP_J774_Mouse0.99729551
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99341251
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98223346
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.97565931
107MYB_26560356_Chip-Seq_TH1_Human0.97383669
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96486214
109RUNX1_22412390_ChIP-Seq_EML_Mouse0.95973125
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95698052
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93060221
112MYB_26560356_Chip-Seq_TH2_Human0.92971689
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92867039
114KDM2B_26808549_Chip-Seq_DND41_Human0.92386452
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91090810
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90966987
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90715976
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89873621
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89755480
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89483460
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87665909
122ELK1_22589737_ChIP-Seq_MCF10A_Human0.86857457
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84861520
124ZNF263_19887448_ChIP-Seq_K562_Human0.83838730
125FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83015871
126PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82412488
127SOX2_16153702_ChIP-ChIP_HESCs_Human0.82228368
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81119180
129STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79926435
130CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79726848
131SOX17_20123909_ChIP-Seq_XEN_Mouse0.76037962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.15621810
2MP0003111_abnormal_nucleus_morphology3.83301222
3MP0010094_abnormal_chromosome_stability3.68285050
4MP0004957_abnormal_blastocyst_morpholog3.62898185
5MP0008057_abnormal_DNA_replication3.57983410
6MP0003077_abnormal_cell_cycle3.36417650
7MP0010352_gastrointestinal_tract_polyps2.75915850
8MP0002396_abnormal_hematopoietic_system2.63784091
9MP0008058_abnormal_DNA_repair2.40724592
10MP0002254_reproductive_system_inflammat2.38035239
11MP0008007_abnormal_cellular_replicative2.35682607
12MP0001730_embryonic_growth_arrest2.24960560
13MP0000350_abnormal_cell_proliferation2.19171265
14MP0006036_abnormal_mitochondrial_physio2.18796920
15MP0003186_abnormal_redox_activity2.15419597
16MP0010307_abnormal_tumor_latency2.11886616
17MP0003941_abnormal_skin_development2.08943365
18MP0003763_abnormal_thymus_physiology2.06748321
19MP0006035_abnormal_mitochondrial_morpho2.02476227
20MP0000490_abnormal_crypts_of2.01197239
21MP0001853_heart_inflammation1.97897972
22MP0008932_abnormal_embryonic_tissue1.90077920
23MP0001727_abnormal_embryo_implantation1.86201062
24MP0009333_abnormal_splenocyte_physiolog1.78746235
25MP0005397_hematopoietic_system_phenotyp1.76755474
26MP0001545_abnormal_hematopoietic_system1.76755474
27MP0005076_abnormal_cell_differentiation1.74641545
28MP0010030_abnormal_orbit_morphology1.73866254
29MP0001672_abnormal_embryogenesis/_devel1.72684481
30MP0005380_embryogenesis_phenotype1.72684481
31MP0000685_abnormal_immune_system1.71598792
32MP0009278_abnormal_bone_marrow1.69170725
33MP0001697_abnormal_embryo_size1.68690145
34MP0003705_abnormal_hypodermis_morpholog1.68300535
35MP0002398_abnormal_bone_marrow1.66364475
36MP0002653_abnormal_ependyma_morphology1.63192853
37MP0002019_abnormal_tumor_incidence1.62890692
38MP0000703_abnormal_thymus_morphology1.60240151
39MP0002086_abnormal_extraembryonic_tissu1.58347584
40MP0003984_embryonic_growth_retardation1.58036199
41MP0004808_abnormal_hematopoietic_stem1.57405105
42MP0005084_abnormal_gallbladder_morpholo1.57085598
43MP0002088_abnormal_embryonic_growth/wei1.55149906
44MP0002722_abnormal_immune_system1.55074329
45MP0004147_increased_porphyrin_level1.54664486
46MP0002080_prenatal_lethality1.54618750
47MP0002085_abnormal_embryonic_tissue1.54597319
48MP0002148_abnormal_hypersensitivity_rea1.53910474
49MP0001764_abnormal_homeostasis1.53825173
50MP0002277_abnormal_respiratory_mucosa1.53311149
51MP0004197_abnormal_fetal_growth/weight/1.52343382
52MP0003786_premature_aging1.52195899
53MP0002084_abnormal_developmental_patter1.50872228
54MP0000689_abnormal_spleen_morphology1.50389832
55MP0009785_altered_susceptibility_to1.47250826
56MP0002796_impaired_skin_barrier1.47230322
57MP0000313_abnormal_cell_death1.43508826
58MP0002139_abnormal_hepatobiliary_system1.40579028
59MP0001800_abnormal_humoral_immune1.36734626
60MP0003123_paternal_imprinting1.32489637
61MP0002429_abnormal_blood_cell1.25031373
62MP0000716_abnormal_immune_system1.22753169
63MP0005023_abnormal_wound_healing1.22568747
64MP0006292_abnormal_olfactory_placode1.20773821
65MP0008260_abnormal_autophagy1.20039728
66MP0003806_abnormal_nucleotide_metabolis1.19618560
67MP0003890_abnormal_embryonic-extraembry1.19257330
68MP0001835_abnormal_antigen_presentation1.18501239
69MP0003195_calcinosis1.17571289
70MP0001529_abnormal_vocalization1.17456875
71MP0002405_respiratory_system_inflammati1.16149112
72MP0002102_abnormal_ear_morphology1.15734313
73MP0000858_altered_metastatic_potential1.15564705
74MP0003436_decreased_susceptibility_to1.13115071
75MP0003566_abnormal_cell_adhesion1.11253530
76MP0002420_abnormal_adaptive_immunity1.09922765
77MP0005367_renal/urinary_system_phenotyp1.09394122
78MP0000516_abnormal_urinary_system1.09394122
79MP0003315_abnormal_perineum_morphology1.08627398
80MP0001819_abnormal_immune_cell1.08604296
81MP0002452_abnormal_antigen_presenting1.08036098
82MP0005671_abnormal_response_to1.08035035
83MP0001293_anophthalmia1.07731028
84MP0009053_abnormal_anal_canal1.05901191
85MP0003119_abnormal_digestive_system1.05344113
86MP0008995_early_reproductive_senescence1.01397456
87MP0002132_abnormal_respiratory_system1.01261363
88MP0008877_abnormal_DNA_methylation1.01153440
89MP0001849_ear_inflammation0.99746643
90MP0002723_abnormal_immune_serum0.97617650
91MP0010155_abnormal_intestine_physiology0.96672049
92MP0002736_abnormal_nociception_after0.96092283
93MP0004133_heterotaxia0.94318000
94MP0001915_intracranial_hemorrhage0.94070287
95MP0005332_abnormal_amino_acid0.92050896
96MP0005636_abnormal_mineral_homeostasis0.91709144
97MP0001919_abnormal_reproductive_system0.91677642
98MP0006082_CNS_inflammation0.90885157
99MP0003567_abnormal_fetal_cardiomyocyte0.89749237
100MP0004019_abnormal_vitamin_homeostasis0.89421624
101MP0005075_abnormal_melanosome_morpholog0.88687041
102MP0008789_abnormal_olfactory_epithelium0.88495416
103MP0001881_abnormal_mammary_gland0.88403457
104MP0006072_abnormal_retinal_apoptosis0.87714274
105MP0009697_abnormal_copulation0.87581412
106MP0003448_altered_tumor_morphology0.87085124
107MP0001845_abnormal_inflammatory_respons0.85975459
108MP0000477_abnormal_intestine_morphology0.85651812
109MP0001188_hyperpigmentation0.85270976
110MP0003718_maternal_effect0.84276426
111MP0001790_abnormal_immune_system0.81693276
112MP0005387_immune_system_phenotype0.81693276
113MP0003011_delayed_dark_adaptation0.80757943
114MP0005621_abnormal_cell_physiology0.79766189
115MP0004264_abnormal_extraembryonic_tissu0.78984765
116MP0005025_abnormal_response_to0.78831464
117MP0000358_abnormal_cell_content/0.78669407
118MP0002111_abnormal_tail_morphology0.78434663
119MP0005000_abnormal_immune_tolerance0.78092460
120MP0008469_abnormal_protein_level0.76649433
121MP0005384_cellular_phenotype0.76332546
122MP0005464_abnormal_platelet_physiology0.74435281
123MP0003303_peritoneal_inflammation0.73947618
124MP0002138_abnormal_hepatobiliary_system0.73690503
125MP0005319_abnormal_enzyme/_coenzyme0.73670177
126MP0001145_abnormal_male_reproductive0.73468809
127MP0001119_abnormal_female_reproductive0.73261168
128MP0005451_abnormal_body_composition0.71515473
129MP0002210_abnormal_sex_determination0.71397296
130MP0001929_abnormal_gametogenesis0.70855584
131MP0008770_decreased_survivor_rate0.70190325
132MP0002092_abnormal_eye_morphology0.69624875
133MP0002419_abnormal_innate_immunity0.69262999
134MP0009703_decreased_birth_body0.69017112
135MP0002089_abnormal_postnatal_growth/wei0.68766324
136MP0005379_endocrine/exocrine_gland_phen0.68588709
137MP0000428_abnormal_craniofacial_morphol0.67881267
138MP0004947_skin_inflammation0.67557271
139MP0003453_abnormal_keratinocyte_physiol0.67101756
140MP0001873_stomach_inflammation0.66938345
141MP0009840_abnormal_foam_cell0.65952499
142MP0005501_abnormal_skin_physiology0.65585911
143MP0003121_genomic_imprinting0.64197325
144MP0009672_abnormal_birth_weight0.63395199
145MP0000371_diluted_coat_color0.62162687

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.27062027
2Mitochondrial inheritance (HP:0001427)4.07554680
3Abnormal mitochondria in muscle tissue (HP:0008316)4.00851931
4Acute encephalopathy (HP:0006846)3.97188814
5Ependymoma (HP:0002888)3.88779812
6Increased CSF lactate (HP:0002490)3.84818349
7Increased hepatocellular lipid droplets (HP:0006565)3.84779304
8Hepatocellular necrosis (HP:0001404)3.76996872
9Lipid accumulation in hepatocytes (HP:0006561)3.68595635
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.65409182
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.65409182
12Selective tooth agenesis (HP:0001592)3.61590005
13Renal Fanconi syndrome (HP:0001994)3.54504552
14Hepatic necrosis (HP:0002605)3.51986198
15Progressive macrocephaly (HP:0004481)3.38972173
16Birth length less than 3rd percentile (HP:0003561)3.32935499
17Increased intramyocellular lipid droplets (HP:0012240)3.30815350
18Cerebral edema (HP:0002181)3.21395751
19Basal cell carcinoma (HP:0002671)3.18345390
20Increased serum pyruvate (HP:0003542)3.14521052
21Type I transferrin isoform profile (HP:0003642)3.09787303
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.00185330
23Lactic acidosis (HP:0003128)2.99482297
24Increased serum lactate (HP:0002151)2.98108384
25Increased muscle lipid content (HP:0009058)2.95122593
26Medulloblastoma (HP:0002885)2.90863995
27Degeneration of anterior horn cells (HP:0002398)2.90028607
28Abnormality of the anterior horn cell (HP:0006802)2.90028607
29Agnosia (HP:0010524)2.88808680
30Oral leukoplakia (HP:0002745)2.88801691
31Patellar aplasia (HP:0006443)2.75097619
32Multiple enchondromatosis (HP:0005701)2.73172264
33Abnormality of glycolysis (HP:0004366)2.71129618
34Rhabdomyosarcoma (HP:0002859)2.71026898
35Reticulocytopenia (HP:0001896)2.70513180
36Breast hypoplasia (HP:0003187)2.68794189
37Chromsome breakage (HP:0040012)2.68274793
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.65885857
39Abnormality of the astrocytes (HP:0100707)2.63156249
40Astrocytoma (HP:0009592)2.63156249
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.62269025
42Abnormal protein N-linked glycosylation (HP:0012347)2.62269025
43Abnormal protein glycosylation (HP:0012346)2.62269025
44Abnormal glycosylation (HP:0012345)2.62269025
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.61937485
46Rib fusion (HP:0000902)2.57529497
47Abnormal number of incisors (HP:0011064)2.56907115
48Abnormality of methionine metabolism (HP:0010901)2.55930911
49Aplasia/Hypoplasia of the patella (HP:0006498)2.53402412
50Respiratory difficulties (HP:0002880)2.51733057
51Exertional dyspnea (HP:0002875)2.51021897
52Pancytopenia (HP:0001876)2.50118359
53Lethargy (HP:0001254)2.48064599
54Absent thumb (HP:0009777)2.47973554
55Abnormality of the ileum (HP:0001549)2.43044544
56Exercise intolerance (HP:0003546)2.42475944
57Rough bone trabeculation (HP:0100670)2.42111118
58Respiratory failure (HP:0002878)2.40516460
59Aplastic anemia (HP:0001915)2.38152768
60Pustule (HP:0200039)2.38070637
61Abnormality of lateral ventricle (HP:0030047)2.38061911
62Microvesicular hepatic steatosis (HP:0001414)2.37066368
63IgM deficiency (HP:0002850)2.36536401
64Sparse eyelashes (HP:0000653)2.34830206
65Methylmalonic acidemia (HP:0002912)2.34558436
66Absent radius (HP:0003974)2.34371373
67Cleft eyelid (HP:0000625)2.34035990
68Myelodysplasia (HP:0002863)2.33212931
69Spinal muscular atrophy (HP:0007269)2.32804244
70Trismus (HP:0000211)2.32514239
71Reduced antithrombin III activity (HP:0001976)2.32398177
72Abnormality of chromosome stability (HP:0003220)2.31912518
73Meckel diverticulum (HP:0002245)2.30828664
74Colon cancer (HP:0003003)2.30548602
75Squamous cell carcinoma (HP:0002860)2.30463084
76Horseshoe kidney (HP:0000085)2.29462852
77Abnormality of cells of the erythroid lineage (HP:0012130)2.28194226
78Methylmalonic aciduria (HP:0012120)2.27436578
79Carpal bone hypoplasia (HP:0001498)2.27191804
80Aplasia/Hypoplasia of the uvula (HP:0010293)2.25220028
81Neoplasm of striated muscle (HP:0009728)2.24482028
82Abnormality of T cells (HP:0002843)2.24268463
83Amaurosis fugax (HP:0100576)2.23656098
84Nausea (HP:0002018)2.21915761
85Abnormality of the labia minora (HP:0012880)2.20903076
86Combined immunodeficiency (HP:0005387)2.18479568
87Thrombocytosis (HP:0001894)2.18253568
88Abnormal number of erythroid precursors (HP:0012131)2.18031472
89Absent forearm bone (HP:0003953)2.17544725
90Aplasia involving forearm bones (HP:0009822)2.17544725
91Increased nuchal translucency (HP:0010880)2.16131425
92Proximal placement of thumb (HP:0009623)2.15419701
93Glioma (HP:0009733)2.15168939
94Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14581378
95Impulsivity (HP:0100710)2.14037526
96Prominent nose (HP:0000448)2.12287444
97Poikiloderma (HP:0001029)2.12000198
98Deviation of the thumb (HP:0009603)2.11885441
99Bone marrow hypocellularity (HP:0005528)2.11449022
100T lymphocytopenia (HP:0005403)2.11252079
101Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11044436
102Abnormality of the preputium (HP:0100587)2.10630051
103Premature graying of hair (HP:0002216)2.10477022
104Lymphoma (HP:0002665)2.10074184
105Premature ovarian failure (HP:0008209)2.09828423
106Atrophy/Degeneration involving motor neurons (HP:0007373)2.09146021
107Macrocytic anemia (HP:0001972)2.08975560
108Dicarboxylic aciduria (HP:0003215)2.08761046
109Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08761046
110Microretrognathia (HP:0000308)2.08719884
111Generalized aminoaciduria (HP:0002909)2.08395701
112Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08119179
113Abnormality of serum amino acid levels (HP:0003112)2.07925626
114Cafe-au-lait spot (HP:0000957)2.07462471
115Intestinal fistula (HP:0100819)2.06711798
116Neoplasm of the pancreas (HP:0002894)2.05874992
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04696777
118Abnormality of T cell physiology (HP:0011840)2.04409002
119CNS demyelination (HP:0007305)2.04257206
120Missing ribs (HP:0000921)2.04250292
121Tracheoesophageal fistula (HP:0002575)2.04168835
122Tongue fasciculations (HP:0001308)2.03635086
123Hyperglycinemia (HP:0002154)2.03175093
124Abnormality of pyrimidine metabolism (HP:0004353)2.01236401
125Glycosuria (HP:0003076)2.01071520
126Abnormality of urine glucose concentration (HP:0011016)2.01071520
127Optic disc pallor (HP:0000543)1.99330637
128Aplasia/hypoplasia of the humerus (HP:0006507)1.98575119
129Aplasia/hypoplasia of the uterus (HP:0008684)1.98429006
130Abnormality of renal resorption (HP:0011038)1.97384454
131Pili torti (HP:0003777)1.96876302
132Rectal fistula (HP:0100590)1.96813897
133Rectovaginal fistula (HP:0000143)1.96813897
134Abnormality of the lower motor neuron (HP:0002366)1.96623873
135Cellular immunodeficiency (HP:0005374)1.95816220
136Facial hemangioma (HP:0000329)1.95646277
137Abnormality of glycine metabolism (HP:0010895)1.95261234
138Abnormality of serine family amino acid metabolism (HP:0010894)1.95261234
139Abnormality of T cell number (HP:0011839)1.94434559
140Small intestinal stenosis (HP:0012848)1.93618466
141Duodenal stenosis (HP:0100867)1.93618466
142Hyperphosphaturia (HP:0003109)1.92576413
14311 pairs of ribs (HP:0000878)1.92526240
144Leukodystrophy (HP:0002415)1.92010155
1453-Methylglutaconic aciduria (HP:0003535)1.91199179
146Hyperglycinuria (HP:0003108)1.90548417
147Neoplasm of the oral cavity (HP:0100649)1.89687605
148Hepatosplenomegaly (HP:0001433)1.89367635
149Cerebral hypomyelination (HP:0006808)1.88458609
150Hypoglycemic seizures (HP:0002173)1.86695729
151Elevated erythrocyte sedimentation rate (HP:0003565)1.85150853
152Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83880580
153Muscle fibrillation (HP:0010546)1.83332353
154Hypoglycemic coma (HP:0001325)1.82897776
155Recurrent viral infections (HP:0004429)1.82864454
156Atresia of the external auditory canal (HP:0000413)1.82771914
157Short humerus (HP:0005792)1.82353435
158Ragged-red muscle fibers (HP:0003200)1.81025107
159Recurrent bronchitis (HP:0002837)1.80250149
160IgG deficiency (HP:0004315)1.80110024
161Acute lymphatic leukemia (HP:0006721)1.78776034
162Hypochromic anemia (HP:0001931)1.77480828
163Abnormal neuron morphology (HP:0012757)1.77284259
164Abnormality of the motor neurons (HP:0002450)1.77284259
165Ulnar bowing (HP:0003031)1.76351463
166Stomatitis (HP:0010280)1.75848305
167Symptomatic seizures (HP:0011145)1.75146372
168Dry hair (HP:0011359)1.74543017
169Severe combined immunodeficiency (HP:0004430)1.74276855
170Personality changes (HP:0000751)1.73760995
171Brittle hair (HP:0002299)1.72943087
172Nasal polyposis (HP:0100582)1.72510398
173Short 4th metacarpal (HP:0010044)1.72376478
174Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72376478
175Abnormal trabecular bone morphology (HP:0100671)1.71990707
176Increased IgM level (HP:0003496)1.70973113

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.41499718
2BUB13.71252261
3MST43.34843383
4CDK123.31764617
5MAP3K103.13042740
6STK163.02557570
7EEF2K2.95038934
8CDC72.79598763
9NEK22.56784563
10MAP4K12.52757171
11WEE12.47028158
12STK102.13152457
13TESK22.12945239
14PBK2.11421321
15PKN22.10341788
16NEK12.07236403
17PASK1.96933686
18ZAK1.92793404
19GRK61.92363050
20EIF2AK11.87986160
21RPS6KB21.84923496
22PDK21.82353798
23CDK71.76907838
24TRIB31.76420195
25TTK1.75128565
26TRIM281.69785173
27MAP3K121.62986864
28FLT31.62404591
29CDK41.59761269
30PLK11.57270253
31NUAK11.54714177
32PIM21.51806688
33PAK41.50680976
34PIM11.46663444
35CDK191.41879006
36ERN11.41676312
37EPHA21.40719248
38DYRK31.39455352
39ATR1.39118938
40LIMK11.33625410
41TSSK61.33236340
42AURKB1.26524450
43MAP3K81.23140586
44NME11.19442996
45NME21.18109366
46ALK1.17923494
47ICK1.12607316
48CHEK11.12501879
49TAF11.11330052
50LRRK21.08424581
51SRPK11.05991969
52ZAP701.04084381
53TLK11.03897677
54CHEK21.03034316
55ACVR1B1.01989277
56CSF1R1.00047281
57MUSK0.98983603
58SCYL20.95612537
59BRSK20.94603473
60MAP3K110.92573573
61STK40.92502639
62DYRK20.88630626
63RPS6KA40.88490078
64CSNK1G30.87430597
65MAPKAPK30.85545506
66MKNK20.85018161
67CDK20.83239787
68TYK20.81781180
69CDK60.80366216
70EIF2AK30.80057642
71BRSK10.77476677
72AURKA0.76820985
73IKBKE0.75652730
74JAK30.75448293
75BTK0.75153379
76MTOR0.74846593
77BMX0.73844782
78MAP4K20.73406799
79TYRO30.73320079
80CSNK1G10.70122621
81EIF2AK20.69279775
82PLK40.68525745
83MATK0.67683430
84ATM0.67675910
85TXK0.67541280
86GRK10.66225022
87SIK30.64781069
88CSK0.64243320
89TESK10.63675781
90MAPK110.63557510
91ILK0.63534579
92TGFBR10.63340616
93SMG10.63257147
94TBK10.62990192
95BLK0.55921942
96BRD40.55732874
97MAP2K30.55408674
98FGFR30.54796496
99PRKCI0.54485574
100MAP2K70.53279743
101ABL20.53101421
102RPS6KL10.53055066
103RPS6KC10.53055066
104FGR0.52891733
105DAPK10.52130659
106FGFR40.52050903
107PDGFRA0.50745514
108AKT20.50329097
109CSNK1G20.50227678
110ITK0.49778022
111VRK10.49480784
112MELK0.49461795
113TEC0.49228042
114CHUK0.49220911
115CDK80.49087095
116DYRK1B0.48626952
117DAPK30.48426559
118RPS6KA60.48373807
119CSNK2A20.48260959
120PAK10.48046601
121CLK10.47256893
122KDR0.46783572
123KIT0.46640170
124IKBKB0.46030995
125PLK30.45745144
126CDK10.45517484
127BCKDK0.44976082
128CSNK1A1L0.44794233
129MKNK10.42722582
130FES0.42316602
131FGFR10.42203466
132LYN0.42008042
133STK30.41582424
134LCK0.41383846
135RPS6KA50.39927045
136CSNK2A10.39509468
137CCNB10.36932241
138WNK30.35956505
139ARAF0.35592450
140BMPR1B0.31624417

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35744539
2Mismatch repair_Homo sapiens_hsa034303.84537666
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42203595
4Base excision repair_Homo sapiens_hsa034103.14101134
5Spliceosome_Homo sapiens_hsa030403.05836259
6Oxidative phosphorylation_Homo sapiens_hsa001903.01149372
7RNA transport_Homo sapiens_hsa030132.84136314
8Ribosome_Homo sapiens_hsa030102.58422332
9Parkinsons disease_Homo sapiens_hsa050122.58228070
10One carbon pool by folate_Homo sapiens_hsa006702.55622595
11Cell cycle_Homo sapiens_hsa041102.45801161
12Nucleotide excision repair_Homo sapiens_hsa034202.28896816
13Homologous recombination_Homo sapiens_hsa034402.28574508
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11417346
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09520277
16RNA polymerase_Homo sapiens_hsa030202.08810875
17mRNA surveillance pathway_Homo sapiens_hsa030151.91212780
18Primary immunodeficiency_Homo sapiens_hsa053401.86132646
19Fanconi anemia pathway_Homo sapiens_hsa034601.84027856
20p53 signaling pathway_Homo sapiens_hsa041151.78809848
21Pyrimidine metabolism_Homo sapiens_hsa002401.75277105
22Huntingtons disease_Homo sapiens_hsa050161.75001827
23Proteasome_Homo sapiens_hsa030501.73342402
24Protein export_Homo sapiens_hsa030601.71505843
25Fatty acid elongation_Homo sapiens_hsa000621.63656625
26RNA degradation_Homo sapiens_hsa030181.61771427
27Non-homologous end-joining_Homo sapiens_hsa034501.59686102
28Pyruvate metabolism_Homo sapiens_hsa006201.44931877
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43550922
30Alzheimers disease_Homo sapiens_hsa050101.41454222
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38926875
32Glutathione metabolism_Homo sapiens_hsa004801.35757952
33Antigen processing and presentation_Homo sapiens_hsa046121.32320234
34Basal transcription factors_Homo sapiens_hsa030221.27329559
35Steroid biosynthesis_Homo sapiens_hsa001001.23163124
36Viral carcinogenesis_Homo sapiens_hsa052031.22947977
37Biosynthesis of amino acids_Homo sapiens_hsa012301.22034711
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21821566
39Herpes simplex infection_Homo sapiens_hsa051681.21806968
40Propanoate metabolism_Homo sapiens_hsa006401.18130021
41Notch signaling pathway_Homo sapiens_hsa043301.16963263
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16169437
43Epstein-Barr virus infection_Homo sapiens_hsa051691.16128316
44Asthma_Homo sapiens_hsa053101.12353571
45Systemic lupus erythematosus_Homo sapiens_hsa053221.09171684
46Pentose phosphate pathway_Homo sapiens_hsa000301.08864021
47Sulfur relay system_Homo sapiens_hsa041221.04309746
48HTLV-I infection_Homo sapiens_hsa051661.04021819
49Allograft rejection_Homo sapiens_hsa053300.96840123
50Acute myeloid leukemia_Homo sapiens_hsa052210.95234150
51Graft-versus-host disease_Homo sapiens_hsa053320.92566930
52Autoimmune thyroid disease_Homo sapiens_hsa053200.91909731
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91564433
54Apoptosis_Homo sapiens_hsa042100.90918474
55Chronic myeloid leukemia_Homo sapiens_hsa052200.90857895
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89948586
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88488341
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87907172
59Selenocompound metabolism_Homo sapiens_hsa004500.87871766
60Colorectal cancer_Homo sapiens_hsa052100.87250815
61Measles_Homo sapiens_hsa051620.87125848
62Peroxisome_Homo sapiens_hsa041460.86816741
63Thyroid cancer_Homo sapiens_hsa052160.86742490
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84590746
65MicroRNAs in cancer_Homo sapiens_hsa052060.84180322
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84132424
67Type I diabetes mellitus_Homo sapiens_hsa049400.83961407
68Small cell lung cancer_Homo sapiens_hsa052220.82877802
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82424702
70Folate biosynthesis_Homo sapiens_hsa007900.82028177
71mTOR signaling pathway_Homo sapiens_hsa041500.81467673
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81388036
73Sulfur metabolism_Homo sapiens_hsa009200.79703372
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.79222588
75Vitamin digestion and absorption_Homo sapiens_hsa049770.77396301
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.77098329
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76498955
78B cell receptor signaling pathway_Homo sapiens_hsa046620.75431043
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75103245
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74924251
81Bladder cancer_Homo sapiens_hsa052190.74665874
82Legionellosis_Homo sapiens_hsa051340.74325216
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.74179206
84Vitamin B6 metabolism_Homo sapiens_hsa007500.73781153
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.73485324
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73350367
87Metabolic pathways_Homo sapiens_hsa011000.72249023
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.71347033
89Hepatitis B_Homo sapiens_hsa051610.70405665
90Fructose and mannose metabolism_Homo sapiens_hsa000510.69865941
91Shigellosis_Homo sapiens_hsa051310.69640072
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.69536632
93T cell receptor signaling pathway_Homo sapiens_hsa046600.69523726
94Rheumatoid arthritis_Homo sapiens_hsa053230.68916226
95Purine metabolism_Homo sapiens_hsa002300.68863594
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68687572
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67101898
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60988898
99Non-small cell lung cancer_Homo sapiens_hsa052230.60539558
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60103967
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59456986
102Viral myocarditis_Homo sapiens_hsa054160.58469805
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57262706
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56468821
105Hippo signaling pathway_Homo sapiens_hsa043900.56379597
106Oocyte meiosis_Homo sapiens_hsa041140.56124988
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55804263
108Lysine degradation_Homo sapiens_hsa003100.55610534
109Pancreatic cancer_Homo sapiens_hsa052120.54763348
110Basal cell carcinoma_Homo sapiens_hsa052170.54384610
111Fat digestion and absorption_Homo sapiens_hsa049750.51884525
112beta-Alanine metabolism_Homo sapiens_hsa004100.51445760
113Collecting duct acid secretion_Homo sapiens_hsa049660.49336818
114Leishmaniasis_Homo sapiens_hsa051400.49310333
115Fatty acid metabolism_Homo sapiens_hsa012120.49143513
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48438798
117Galactose metabolism_Homo sapiens_hsa000520.48372934
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.47433120
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47204663
120Hematopoietic cell lineage_Homo sapiens_hsa046400.46642551
121HIF-1 signaling pathway_Homo sapiens_hsa040660.46598755
122Influenza A_Homo sapiens_hsa051640.45964153
123Carbon metabolism_Homo sapiens_hsa012000.45730265
124N-Glycan biosynthesis_Homo sapiens_hsa005100.44752153
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44457101
126Butanoate metabolism_Homo sapiens_hsa006500.43583329
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43213533
128Fatty acid degradation_Homo sapiens_hsa000710.42496695
129Tryptophan metabolism_Homo sapiens_hsa003800.38870449
130Pathways in cancer_Homo sapiens_hsa052000.37787212
131Adherens junction_Homo sapiens_hsa045200.37476510
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.37383540
133Chemical carcinogenesis_Homo sapiens_hsa052040.36135755
134Endometrial cancer_Homo sapiens_hsa052130.35493552
135TGF-beta signaling pathway_Homo sapiens_hsa043500.34733590
136VEGF signaling pathway_Homo sapiens_hsa043700.34256905
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.33512624
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33222222
139Cardiac muscle contraction_Homo sapiens_hsa042600.32737629
140Arginine and proline metabolism_Homo sapiens_hsa003300.32481530
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31322302
142Toxoplasmosis_Homo sapiens_hsa051450.29871249
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27413257
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27270703
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26247779
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23887879
147Hedgehog signaling pathway_Homo sapiens_hsa043400.23294790
148Proteoglycans in cancer_Homo sapiens_hsa052050.23082196

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