PYROXD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.11836720
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.11836720
3L-phenylalanine metabolic process (GO:0006558)6.86460635
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.86460635
5aromatic amino acid family catabolic process (GO:0009074)6.49113964
6glyoxylate metabolic process (GO:0046487)6.02142083
7indole-containing compound catabolic process (GO:0042436)5.94773654
8indolalkylamine catabolic process (GO:0046218)5.94773654
9tryptophan catabolic process (GO:0006569)5.94773654
10tryptophan metabolic process (GO:0006568)5.77747190
11kynurenine metabolic process (GO:0070189)5.61480817
12cysteine metabolic process (GO:0006534)5.58979347
13lysine metabolic process (GO:0006553)5.44064781
14lysine catabolic process (GO:0006554)5.44064781
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.33544425
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.30847581
17bile acid biosynthetic process (GO:0006699)5.24046122
18alpha-linolenic acid metabolic process (GO:0036109)5.23201053
19drug transmembrane transport (GO:0006855)5.16190709
20sulfur amino acid catabolic process (GO:0000098)5.08219845
21urate metabolic process (GO:0046415)4.80492305
22serine family amino acid catabolic process (GO:0009071)4.78862686
23aromatic amino acid family metabolic process (GO:0009072)4.77227779
24amino-acid betaine metabolic process (GO:0006577)4.75305624
25urea metabolic process (GO:0019627)4.72926477
26urea cycle (GO:0000050)4.72926477
27peptidyl-glutamic acid carboxylation (GO:0017187)4.69520685
28protein carboxylation (GO:0018214)4.69520685
29high-density lipoprotein particle remodeling (GO:0034375)4.64375242
30homocysteine metabolic process (GO:0050667)4.64088535
31cellular ketone body metabolic process (GO:0046950)4.56070135
32tyrosine metabolic process (GO:0006570)4.54867090
33drug catabolic process (GO:0042737)4.52697489
34bile acid metabolic process (GO:0008206)4.45228625
35negative regulation of fibrinolysis (GO:0051918)4.44427508
36alpha-amino acid catabolic process (GO:1901606)4.41937249
37complement activation, alternative pathway (GO:0006957)4.39205579
38nitrogen cycle metabolic process (GO:0071941)4.34502661
39indolalkylamine metabolic process (GO:0006586)4.33447380
40short-chain fatty acid metabolic process (GO:0046459)4.29568649
41drug transport (GO:0015893)4.26051175
42regulation of fibrinolysis (GO:0051917)4.24537907
43regulation of protein activation cascade (GO:2000257)4.24268816
44cellular amino acid catabolic process (GO:0009063)4.18982729
45regulation of triglyceride catabolic process (GO:0010896)4.18907702
46cellular modified amino acid catabolic process (GO:0042219)4.18730334
47reverse cholesterol transport (GO:0043691)4.17113121
48valine metabolic process (GO:0006573)4.15208803
49triglyceride homeostasis (GO:0070328)4.15043212
50acylglycerol homeostasis (GO:0055090)4.15043212
51glutamate metabolic process (GO:0006536)4.13841178
52negative regulation of granulocyte differentiation (GO:0030853)4.07832342
53benzene-containing compound metabolic process (GO:0042537)4.07641132
54negative regulation of sterol transport (GO:0032372)4.06142291
55negative regulation of cholesterol transport (GO:0032375)4.06142291
56regulation of cholesterol esterification (GO:0010872)4.04937343
57serine family amino acid metabolic process (GO:0009069)4.04770742
58cellular biogenic amine catabolic process (GO:0042402)4.04683587
59amine catabolic process (GO:0009310)4.04683587
60cellular glucuronidation (GO:0052695)3.99961886
61protein-lipid complex remodeling (GO:0034368)3.99261192
62macromolecular complex remodeling (GO:0034367)3.99261192
63plasma lipoprotein particle remodeling (GO:0034369)3.99261192
64regulation of cholesterol homeostasis (GO:2000188)3.96546550
65regulation of complement activation (GO:0030449)3.96255814
66ketone body metabolic process (GO:1902224)3.96139314
67exogenous drug catabolic process (GO:0042738)3.93972566
682-oxoglutarate metabolic process (GO:0006103)3.93027437
69fatty acid beta-oxidation (GO:0006635)3.92758359
70phospholipid efflux (GO:0033700)3.91667736
71fatty acid oxidation (GO:0019395)3.84390349
72aspartate family amino acid catabolic process (GO:0009068)3.83115410
73regulation of extracellular matrix disassembly (GO:0010715)3.81071684
74ethanol oxidation (GO:0006069)3.80986599
75acetyl-CoA metabolic process (GO:0006084)3.80122108
76carboxylic acid catabolic process (GO:0046395)3.79634945
77organic acid catabolic process (GO:0016054)3.79634945
78carnitine metabolic process (GO:0009437)3.79411041
79bile acid and bile salt transport (GO:0015721)3.78845942
80coenzyme catabolic process (GO:0009109)3.77449963
81lipid oxidation (GO:0034440)3.77306534
82aldehyde catabolic process (GO:0046185)3.76627000
83plasma lipoprotein particle clearance (GO:0034381)3.74989266
84monocarboxylic acid catabolic process (GO:0072329)3.70178925
85serine family amino acid biosynthetic process (GO:0009070)3.68527541
86glucuronate metabolic process (GO:0019585)3.66875871
87uronic acid metabolic process (GO:0006063)3.66875871
88glycine metabolic process (GO:0006544)3.66662980
89phospholipid homeostasis (GO:0055091)3.66397462
90fatty acid catabolic process (GO:0009062)3.65482007
91dicarboxylic acid biosynthetic process (GO:0043650)3.60332047
92cholesterol efflux (GO:0033344)3.54284255
93branched-chain amino acid metabolic process (GO:0009081)3.48999754
94plasma lipoprotein particle assembly (GO:0034377)3.48850453
95regulation of T cell tolerance induction (GO:0002664)3.48178392
96imidazole-containing compound metabolic process (GO:0052803)3.48160264
97positive regulation of lipoprotein lipase activity (GO:0051006)3.46660084
98positive regulation of triglyceride lipase activity (GO:0061365)3.46660084
99cholesterol homeostasis (GO:0042632)3.46561100
100sterol homeostasis (GO:0055092)3.44979033
101drug metabolic process (GO:0017144)3.38493261
102branched-chain amino acid catabolic process (GO:0009083)3.38221005
103response to mercury ion (GO:0046689)3.38193115
104mannose metabolic process (GO:0006013)3.37580850
105negative regulation of erythrocyte differentiation (GO:0045647)3.33698473
106regulation of tolerance induction (GO:0002643)3.25920829
107positive regulation of mast cell activation involved in immune response (GO:0033008)3.24058991
108positive regulation of mast cell degranulation (GO:0043306)3.24058991
109regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.21743687
110negative regulation of execution phase of apoptosis (GO:1900118)3.14130020
111regulation of type B pancreatic cell apoptotic process (GO:2000674)3.10090316
112regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.06089659
113macroautophagy (GO:0016236)3.04591394
114regulation of mast cell activation involved in immune response (GO:0033006)2.97492548
115regulation of granulocyte differentiation (GO:0030852)2.96197442
116negative regulation of humoral immune response (GO:0002921)2.91893762
117regulation of sequestering of triglyceride (GO:0010889)2.90305097
118sequestering of extracellular ligand from receptor (GO:0035581)2.86137306
119positive regulation of transforming growth factor beta production (GO:0071636)2.86023875
120positive regulation of natural killer cell differentiation (GO:0032825)2.85128515
121regulation of T cell cytokine production (GO:0002724)2.84485142
122axoneme assembly (GO:0035082)2.84324425
123regulation of fatty acid oxidation (GO:0046320)2.78943676
124regulation of mast cell degranulation (GO:0043304)2.68849127
125keratan sulfate catabolic process (GO:0042340)2.68590601
126regulation of execution phase of apoptosis (GO:1900117)2.65885158
127negative regulation of complement activation (GO:0045916)2.60911696
128ethanol metabolic process (GO:0006067)2.57561565
129fatty acid transmembrane transport (GO:1902001)2.57195775
130positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57096857
131norepinephrine metabolic process (GO:0042415)2.49140461
132positive regulation of mast cell activation (GO:0033005)2.49018945
133negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.44564569
134white fat cell differentiation (GO:0050872)2.44397728
135positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.43094448
136carnitine transmembrane transport (GO:1902603)2.42968441
137glycogen catabolic process (GO:0005980)2.39511896
138cilium movement (GO:0003341)2.39353664
139regulation of inositol phosphate biosynthetic process (GO:0010919)2.38999649
140carnitine transport (GO:0015879)2.38435962
141amino-acid betaine transport (GO:0015838)2.38435962
142regulation of integrin-mediated signaling pathway (GO:2001044)2.38000746
143phosphatidylcholine biosynthetic process (GO:0006656)2.36652427
144positive regulation of histone deacetylation (GO:0031065)2.36495636
145positive regulation of leukocyte degranulation (GO:0043302)2.35910693
146triglyceride catabolic process (GO:0019433)2.35798064
147phosphatidylethanolamine biosynthetic process (GO:0006646)2.33826361
148epithelial cilium movement (GO:0003351)2.30753285
149positive regulation of receptor recycling (GO:0001921)2.30721193
150lipoxygenase pathway (GO:0019372)2.30578847
151amyloid precursor protein catabolic process (GO:0042987)2.30466829
152phosphatidylglycerol biosynthetic process (GO:0006655)2.29820700
153peroxisome fission (GO:0016559)2.29536721
154response to epinephrine (GO:0071871)2.29255031
155regulation of clathrin-mediated endocytosis (GO:2000369)2.28873534
156carnitine shuttle (GO:0006853)2.28482947
157lytic vacuole organization (GO:0080171)2.26969695
158lysosome organization (GO:0007040)2.26969695
159eosinophil chemotaxis (GO:0048245)2.25304472
160response to water (GO:0009415)2.25122895
161positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.24946603
162endosome to melanosome transport (GO:0035646)2.24916955
163endosome to pigment granule transport (GO:0043485)2.24916955
164T cell apoptotic process (GO:0070231)2.24211229
165negative regulation of protein activation cascade (GO:2000258)2.23900946
166low-density lipoprotein particle clearance (GO:0034383)2.23464565
167fibril organization (GO:0097435)2.23398789
168face development (GO:0060324)2.21369656
169cellular polysaccharide catabolic process (GO:0044247)2.19925738
170positive regulation of granulocyte differentiation (GO:0030854)2.19027646
171peptide hormone processing (GO:0016486)2.18396363
172regulation of plasminogen activation (GO:0010755)2.18333288
173glucan catabolic process (GO:0009251)2.17728276
174regulation of mast cell activation (GO:0033003)2.17362616
175cellular response to epinephrine stimulus (GO:0071872)2.15473927
176intestinal cholesterol absorption (GO:0030299)2.14467216
177angiogenesis involved in wound healing (GO:0060055)2.14220626
178epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.13258273
179eosinophil migration (GO:0072677)2.12813507
180axonemal dynein complex assembly (GO:0070286)2.11301004
181lymphocyte apoptotic process (GO:0070227)2.11294343
182phosphatidylethanolamine metabolic process (GO:0046337)2.11139450
183virion attachment to host cell (GO:0019062)2.10718295
184adhesion of symbiont to host cell (GO:0044650)2.10718295
185negative regulation of cell size (GO:0045792)2.10262847
186negative regulation of interleukin-8 production (GO:0032717)2.09684591
187extracellular negative regulation of signal transduction (GO:1900116)2.08604282
188extracellular regulation of signal transduction (GO:1900115)2.08604282
189adhesion of symbiont to host (GO:0044406)2.07362091
190xenobiotic catabolic process (GO:0042178)2.07337453
191insulin-like growth factor receptor signaling pathway (GO:0048009)2.06062518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.89918352
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.84025894
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.22459862
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.82024146
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.17054192
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.71270009
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.19543538
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.95839222
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.89236191
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.54763633
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38587858
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.34445366
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06215010
14CLOCK_20551151_ChIP-Seq_293T_Human2.06090628
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9155350
16GATA2_21666600_ChIP-Seq_HMVEC_Human1.84931789
17GATA1_22025678_ChIP-Seq_K562_Human1.82568835
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81211897
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.71223909
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68193127
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56209925
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55029923
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53579326
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.51578190
25HNF4A_19822575_ChIP-Seq_HepG2_Human1.49284544
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48431955
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.47640208
28LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42163070
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.41590783
30VDR_21846776_ChIP-Seq_THP-1_Human1.39682113
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38333132
32SPI1_23127762_ChIP-Seq_K562_Human1.37493362
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37090312
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36484173
35RUNX_20019798_ChIP-Seq_JUKART_Human1.35801469
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.30294002
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30109551
38VDR_24763502_ChIP-Seq_THP-1_Human1.27726645
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27551058
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26841311
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.26298367
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25867327
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23793806
44SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23700695
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22726465
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22235345
47TP53_22127205_ChIP-Seq_IMR90_Human1.21799730
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21717460
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21527405
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20088063
51* BCL6_27268052_Chip-Seq_Bcells_Human1.19723355
52TCF7_22412390_ChIP-Seq_EML_Mouse1.19295032
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.17149361
54* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16883537
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16348061
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15672315
57P68_20966046_ChIP-Seq_HELA_Human1.14701481
58* MAF_26560356_Chip-Seq_TH2_Human1.14581762
59GATA4_25053715_ChIP-Seq_YYC3_Human1.13917344
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.13580957
61KDM2B_26808549_Chip-Seq_DND41_Human1.12196935
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.11215170
63SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09091814
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06699611
65CTCF_26484167_Chip-Seq_Bcells_Mouse1.04318200
66BCOR_27268052_Chip-Seq_Bcells_Human1.04314081
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04099454
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01068132
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00093746
70SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99563820
71RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99018851
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98864481
73CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98394915
74SMC4_20622854_ChIP-Seq_HELA_Human0.97281344
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97205407
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96502506
77UTX_26944678_Chip-Seq_JUKART_Human0.96073730
78SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95646561
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94862822
80ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94500266
81SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94422317
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94383711
83MAF_26560356_Chip-Seq_TH1_Human0.94152820
84IRF8_21731497_ChIP-ChIP_J774_Mouse0.94044732
85* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93948786
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93585856
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93525870
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93476589
89* TP63_22573176_ChIP-Seq_HFKS_Human0.92995199
90MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91223968
91HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90974758
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90667435
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90030154
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89891835
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89864897
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.89292372
97ZNF263_19887448_ChIP-Seq_K562_Human0.86758167
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85537092
99CDX2_20551321_ChIP-Seq_CACO-2_Human0.84645515
100LXR_22292898_ChIP-Seq_THP-1_Human0.84141524
101TRIM28_21343339_ChIP-Seq_HEK293_Human0.80659124
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80014037
103HTT_18923047_ChIP-ChIP_STHdh_Human0.79296740
104GATA1_19941826_ChIP-Seq_K562_Human0.77776306
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.77653249
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.77430556
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.72158993
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71225890
109* TBX20_22328084_ChIP-Seq_HEART_Mouse0.70593268
110* TBX20_22080862_ChIP-Seq_HEART_Mouse0.70593268
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69636691
112NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69237934
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69237934
114AR_20517297_ChIP-Seq_VCAP_Human0.69033742
115GATA6_25053715_ChIP-Seq_YYC3_Human0.68393160
116GATA2_19941826_ChIP-Seq_K562_Human0.67915261
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66854178
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65905575
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.64501831
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64257360
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.63972094
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.63442377
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62830632
124EGR1_19032775_ChIP-ChIP_M12_Human0.62669010
125GATA1_19941827_ChIP-Seq_MEL_Mouse0.62135957
126* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61349237
127SOX2_20726797_ChIP-Seq_SW620_Human0.61238375
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61201860
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.61174444
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60937694
131CEBPB_22108803_ChIP-Seq_LS180_Human0.60506825
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60000258
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58343060
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.57614636
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.57186485
136FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.57017641
137ESET_19884257_ChIP-Seq_ESCs_Mouse0.55603211
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.55500564
139STAT1_17558387_ChIP-Seq_HELA_Human0.55375355
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.55206391
141BCAT_22108803_ChIP-Seq_LS180_Human0.54460869
142PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.54362967
143RACK7_27058665_Chip-Seq_MCF-7_Human0.53805999
144RARA_24833708_ChIP-Seq_LIVER_Mouse0.53729485
145KAP1_22055183_ChIP-Seq_ESCs_Mouse0.52932376
146* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.52628256
147STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51365102
148MYC_19915707_ChIP-ChIP_AK7_Human0.50153817
149* CBP_21632823_ChIP-Seq_H3396_Human0.50006408
150SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.49307386
151CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.48549121
152SCL_19346495_ChIP-Seq_HPC-7_Human0.48411471
153RARB_24833708_ChIP-Seq_LIVER_Mouse0.47325158
154GATA3_24758297_ChIP-Seq_MCF-7_Human0.46545377
155BRD4_27068464_Chip-Seq_AML-cells_Mouse0.46468247
156IRF8_27001747_Chip-Seq_BMDM_Mouse0.45591175
157LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.45537695
158AR_21909140_ChIP-Seq_LNCAP_Human0.45460157
159PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45433749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.98078798
2MP0005360_urolithiasis7.76714330
3MP0005085_abnormal_gallbladder_physiolo5.47257323
4MP0005365_abnormal_bile_salt5.43542672
5MP0008875_abnormal_xenobiotic_pharmacok4.67203097
6MP0003252_abnormal_bile_duct3.76150332
7MP0003195_calcinosis3.64031256
8MP0003806_abnormal_nucleotide_metabolis3.36356477
9MP0010329_abnormal_lipoprotein_level3.26928353
10MP0005332_abnormal_amino_acid3.22558636
11MP0004019_abnormal_vitamin_homeostasis2.88513799
12MP0009840_abnormal_foam_cell2.84000485
13MP0008438_abnormal_cutaneous_collagen2.82424702
14MP0003279_aneurysm2.81980881
15MP0000013_abnormal_adipose_tissue2.45276870
16MP0003191_abnormal_cellular_cholesterol2.44987631
17MP0001666_abnormal_nutrient_absorption2.33886711
18MP0005083_abnormal_biliary_tract2.33641855
19MP0002138_abnormal_hepatobiliary_system2.33293265
20MP0005503_abnormal_tendon_morphology2.29713343
21MP0009643_abnormal_urine_homeostasis2.08685736
22MP0000751_myopathy2.05326269
23MP0000609_abnormal_liver_physiology2.01620415
24MP0002118_abnormal_lipid_homeostasis2.01282237
25MP0000003_abnormal_adipose_tissue2.01121818
26MP0005075_abnormal_melanosome_morpholog1.91962065
27MP0005319_abnormal_enzyme/_coenzyme1.88055186
28MP0002933_joint_inflammation1.80107892
29MP0001958_emphysema1.78804656
30MP0005330_cardiomyopathy1.78523331
31MP0009780_abnormal_chondrocyte_physiolo1.74768833
32MP0004043_abnormal_pH_regulation1.66628768
33MP0005584_abnormal_enzyme/coenzyme_acti1.65246000
34MP0001764_abnormal_homeostasis1.62529754
35MP0005636_abnormal_mineral_homeostasis1.56697709
36MP0005451_abnormal_body_composition1.48375942
37MP0009697_abnormal_copulation1.47590069
38MP0002909_abnormal_adrenal_gland1.47566842
39MP0001542_abnormal_bone_strength1.37343758
40MP0004133_heterotaxia1.37209639
41MP0004084_abnormal_cardiac_muscle1.35601439
42MP0005171_absent_coat_pigmentation1.33786740
43MP0003186_abnormal_redox_activity1.33307649
44MP0003868_abnormal_feces_composition1.29574470
45MP0001756_abnormal_urination1.27393284
46MP0002127_abnormal_cardiovascular_syste1.27161092
47MP0001873_stomach_inflammation1.22334555
48MP0003183_abnormal_peptide_metabolism1.22330656
49MP0006054_spinal_hemorrhage1.20711793
50MP0001765_abnormal_ion_homeostasis1.20232096
51MP0003705_abnormal_hypodermis_morpholog1.19859076
52MP0005670_abnormal_white_adipose1.17368956
53MP0000749_muscle_degeneration1.13283800
54MP0004036_abnormal_muscle_relaxation1.13191476
55MP0002136_abnormal_kidney_physiology1.12917605
56MP0008775_abnormal_heart_ventricle1.12280547
57MP0003828_pulmonary_edema1.12263001
58MP0001881_abnormal_mammary_gland1.12118702
59MP0000598_abnormal_liver_morphology1.11348487
60MP0002876_abnormal_thyroid_physiology1.10364118
61MP0002132_abnormal_respiratory_system1.10245423
62MP0005379_endocrine/exocrine_gland_phen1.09936479
63MP0002108_abnormal_muscle_morphology1.09791176
64MP0005647_abnormal_sex_gland1.07083610
65MP0001533_abnormal_skeleton_physiology1.05063332
66MP0000767_abnormal_smooth_muscle1.04147474
67MP0006138_congestive_heart_failure1.03627773
68MP0000604_amyloidosis1.03252065
69MP0001835_abnormal_antigen_presentation1.02540582
70MP0010386_abnormal_urinary_bladder1.01164122
71MP0005058_abnormal_lysosome_morphology1.00825776
72MP0009764_decreased_sensitivity_to0.99800633
73MP0004087_abnormal_muscle_fiber0.99294147
74MP0002653_abnormal_ependyma_morphology0.97782563
75MP0002166_altered_tumor_susceptibility0.96919980
76MP0005164_abnormal_response_to0.96075822
77MP0009642_abnormal_blood_homeostasis0.96074183
78MP0003011_delayed_dark_adaptation0.95488624
79MP0003566_abnormal_cell_adhesion0.94667215
80MP0002078_abnormal_glucose_homeostasis0.94153878
81MP0001661_extended_life_span0.93367153
82MP0002693_abnormal_pancreas_physiology0.93036180
83MP0008469_abnormal_protein_level0.91427953
84MP0005452_abnormal_adipose_tissue0.90912299
85MP0002419_abnormal_innate_immunity0.90472079
86MP0002405_respiratory_system_inflammati0.90389796
87MP0000343_altered_response_to0.89295656
88MP0009763_increased_sensitivity_to0.88595379
89MP0002837_dystrophic_cardiac_calcinosis0.88232693
90MP0002972_abnormal_cardiac_muscle0.87963085
91MP0006036_abnormal_mitochondrial_physio0.87840654
92MP0005535_abnormal_body_temperature0.86697022
93MP0005220_abnormal_exocrine_pancreas0.86597862
94MP0005025_abnormal_response_to0.84623366
95MP0004130_abnormal_muscle_cell0.82810526
96MP0005334_abnormal_fat_pad0.82467407
97MP0005084_abnormal_gallbladder_morpholo0.81741148
98MP0004883_abnormal_blood_vessel0.80514145
99MP0002128_abnormal_blood_circulation0.80402872
100MP0000750_abnormal_muscle_regeneration0.80315484
101MP0002254_reproductive_system_inflammat0.80078577
102MP0005390_skeleton_phenotype0.79783688
103MP0001851_eye_inflammation0.79773154
104MP0003656_abnormal_erythrocyte_physiolo0.78445456
105MP0004381_abnormal_hair_follicle0.77995124
106MP0004484_altered_response_of0.75359410
107MP0000230_abnormal_systemic_arterial0.74607117
108MP0005620_abnormal_muscle_contractility0.74318781
109MP0002971_abnormal_brown_adipose0.73901321
110MP0005666_abnormal_adipose_tissue0.73495368
111MP0010368_abnormal_lymphatic_system0.72492525
112MP0001544_abnormal_cardiovascular_syste0.72431946
113MP0005385_cardiovascular_system_phenoty0.72431946
114MP0000733_abnormal_muscle_development0.72098817
115MP0000858_altered_metastatic_potential0.71778487
116MP0000759_abnormal_skeletal_muscle0.71142421
117MP0002928_abnormal_bile_duct0.70713939
118MP0005376_homeostasis/metabolism_phenot0.70581353
119MP0008961_abnormal_basal_metabolism0.69515777
120MP0003690_abnormal_glial_cell0.69252656
121MP0005408_hypopigmentation0.68214220
122MP0003300_gastrointestinal_ulcer0.66022206
123MP0002168_other_aberrant_phenotype0.65264005
124MP0003329_amyloid_beta_deposits0.62993837
125MP0009384_cardiac_valve_regurgitation0.61552816
126MP0009765_abnormal_xenobiotic_induced0.60694583
127MP0003953_abnormal_hormone_level0.59631539
128MP0003638_abnormal_response/metabolism_0.57730499
129MP0004264_abnormal_extraembryonic_tissu0.54938488
130MP0003724_increased_susceptibility_to0.53217829
131MP0000639_abnormal_adrenal_gland0.52818590
132MP0005266_abnormal_metabolism0.51923045
133MP0005448_abnormal_energy_balance0.50208014
134MP0005395_other_phenotype0.49883722
135MP0005464_abnormal_platelet_physiology0.49286572
136MP0002135_abnormal_kidney_morphology0.48834454
137MP0001944_abnormal_pancreas_morphology0.48059280
138MP0002896_abnormal_bone_mineralization0.46299434
139MP0004147_increased_porphyrin_level0.45460510
140MP0000538_abnormal_urinary_bladder0.44753790
141MP0006035_abnormal_mitochondrial_morpho0.44639845
142MP0003075_altered_response_to0.43981007
143MP0003172_abnormal_lysosome_physiology0.42933573
144MP0000249_abnormal_blood_vessel0.42530660
145MP0005375_adipose_tissue_phenotype0.38629002
146MP0009672_abnormal_birth_weight0.37518234
147MP0009115_abnormal_fat_cell0.37413874
148MP0006082_CNS_inflammation0.37376988
149MP0008873_increased_physiological_sensi0.37238529
150MP0001845_abnormal_inflammatory_respons0.36854278
151MP0005167_abnormal_blood-brain_barrier0.36544613
152MP0003436_decreased_susceptibility_to0.36024740
153MP0003959_abnormal_lean_body0.35138328
154MP0005166_decreased_susceptibility_to0.34665027
155MP0005595_abnormal_vascular_smooth0.34525035
156MP0002970_abnormal_white_adipose0.31647457
157MP0002295_abnormal_pulmonary_circulatio0.31550746
158MP0000371_diluted_coat_color0.31200979

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.46048924
2Intrahepatic cholestasis (HP:0001406)5.83900133
3Deep venous thrombosis (HP:0002625)5.75309839
4Xanthomatosis (HP:0000991)5.36015077
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.30556730
6Prolonged partial thromboplastin time (HP:0003645)4.99594066
7J-shaped sella turcica (HP:0002680)4.76697007
8Hypobetalipoproteinemia (HP:0003563)4.75122370
9Complement deficiency (HP:0004431)4.64964740
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.59100941
11Ketosis (HP:0001946)4.58410883
12Hyperglycinuria (HP:0003108)4.53271240
13Hyperammonemia (HP:0001987)4.22977576
14Abnormality of serine family amino acid metabolism (HP:0010894)4.21948474
15Abnormality of glycine metabolism (HP:0010895)4.21948474
16Hypoglycemic coma (HP:0001325)4.15202697
17Hyperlipoproteinemia (HP:0010980)4.13738800
18Cervical subluxation (HP:0003308)4.12437226
19Hyperglycinemia (HP:0002154)4.09749786
20Ketoacidosis (HP:0001993)3.98504076
21Gout (HP:0001997)3.97683848
22Abnormality of mucopolysaccharide metabolism (HP:0011020)3.95690452
23Abnormality of polysaccharide metabolism (HP:0011012)3.95690452
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.95690452
25Generalized aminoaciduria (HP:0002909)3.91524944
26Mucopolysacchariduria (HP:0008155)3.89259783
27Urinary glycosaminoglycan excretion (HP:0003541)3.89259783
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.83988834
29Joint hemorrhage (HP:0005261)3.83399587
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.82124098
31Abnormality of fatty-acid metabolism (HP:0004359)3.71877112
32Abnormality of the common coagulation pathway (HP:0010990)3.71326893
33Dysostosis multiplex (HP:0000943)3.69011541
34Hypolipoproteinemia (HP:0010981)3.56743250
35Abnormality of purine metabolism (HP:0004352)3.54250138
36Abnormality of nucleobase metabolism (HP:0010932)3.45700824
37Nuclear cataract (HP:0100018)3.44189187
38Joint stiffness (HP:0001387)3.41989836
39Epidermoid cyst (HP:0200040)3.41343694
40Fat malabsorption (HP:0002630)3.40757257
41Abnormality of the intrinsic pathway (HP:0010989)3.34896209
42Abnormality of pyrimidine metabolism (HP:0004353)3.28602197
43Abnormality of complement system (HP:0005339)3.28457232
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.24097719
45Protrusio acetabuli (HP:0003179)3.17868436
46Asymmetric septal hypertrophy (HP:0001670)3.17165299
47Proximal tubulopathy (HP:0000114)3.16544607
48Hypoalphalipoproteinemia (HP:0003233)3.14689651
49Conjugated hyperbilirubinemia (HP:0002908)3.13478415
50Abnormality of methionine metabolism (HP:0010901)3.12201472
51Delayed CNS myelination (HP:0002188)3.11545556
52Deformed sella turcica (HP:0002681)3.11416096
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.08720435
54Systemic lupus erythematosus (HP:0002725)3.04901745
55Alkalosis (HP:0001948)2.94495861
56Hypercholesterolemia (HP:0003124)2.90217839
57Prolonged bleeding time (HP:0003010)2.88627265
58Dicarboxylic aciduria (HP:0003215)2.87997401
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87997401
60Hyperbilirubinemia (HP:0002904)2.87663715
61Metabolic acidosis (HP:0001942)2.86862038
62Hypoglycemic seizures (HP:0002173)2.85659558
63Vascular calcification (HP:0004934)2.82269206
64Glucose intolerance (HP:0000833)2.75791252
65Hepatocellular carcinoma (HP:0001402)2.74198863
66Aortic aneurysm (HP:0004942)2.73988645
67Glomerulonephritis (HP:0000099)2.70620790
68Increased purine levels (HP:0004368)2.68371788
69Hyperuricemia (HP:0002149)2.68371788
70Abnormality of serum amino acid levels (HP:0003112)2.64909648
71Symptomatic seizures (HP:0011145)2.62132857
72Abnormality of urine glucose concentration (HP:0011016)2.62052401
73Glycosuria (HP:0003076)2.62052401
74Vertebral compression fractures (HP:0002953)2.61234635
75Late onset (HP:0003584)2.59836709
76Enlarged kidneys (HP:0000105)2.56476169
77Ovoid vertebral bodies (HP:0003300)2.55691272
78Lethargy (HP:0001254)2.53505323
79Spontaneous hematomas (HP:0007420)2.51731386
80Cardiovascular calcification (HP:0011915)2.51564189
81Sensorimotor neuropathy (HP:0007141)2.50991188
82Malnutrition (HP:0004395)2.49561177
83Vascular tortuosity (HP:0004948)2.49480132
84Elevated erythrocyte sedimentation rate (HP:0003565)2.48523763
85Rickets (HP:0002748)2.47891672
86Hydroxyprolinuria (HP:0003080)2.44859315
87Abnormality of proline metabolism (HP:0010907)2.44859315
88Skin nodule (HP:0200036)2.44699789
89Abnormality of glycolipid metabolism (HP:0010969)2.43822772
90Abnormality of liposaccharide metabolism (HP:0010968)2.43822772
91Abnormality of glycosphingolipid metabolism (HP:0004343)2.43822772
92Myocardial infarction (HP:0001658)2.43749378
93Cerebral aneurysm (HP:0004944)2.43289336
94Steatorrhea (HP:0002570)2.42374776
95Increased circulating renin level (HP:0000848)2.41686852
96Aortic dissection (HP:0002647)2.40916985
97Rhinitis (HP:0012384)2.39908954
98Hypokalemic alkalosis (HP:0001949)2.38168632
99Irritability (HP:0000737)2.37938505
100Hypoplasia of the odontoid process (HP:0003311)2.36839802
101Arterial tortuosity (HP:0005116)2.36515895
102Hyperinsulinemic hypoglycemia (HP:0000825)2.35734713
103Vomiting (HP:0002013)2.34910430
104Abnormal enzyme/coenzyme activity (HP:0012379)2.31085412
105Abnormal respiratory motile cilium morphology (HP:0005938)2.30458582
106Abnormal respiratory epithelium morphology (HP:0012253)2.30458582
107Pancreatitis (HP:0001733)2.28888062
108Protuberant abdomen (HP:0001538)2.26805166
109Decreased circulating renin level (HP:0003351)2.26463472
110Hyperactive renin-angiotensin system (HP:0000841)2.25989315
111Aortic regurgitation (HP:0001659)2.25725117
112Albinism (HP:0001022)2.22742984
113Lymphangioma (HP:0100764)2.21502018
114Hematochezia (HP:0002573)2.20285082
115Mesangial abnormality (HP:0001966)2.19482940
116Hypophosphatemia (HP:0002148)2.17465548
117Abnormal ciliary motility (HP:0012262)2.17384265
118Abnormal urine output (HP:0012590)2.15905940
119Spastic diplegia (HP:0001264)2.14486880
120Metabolic alkalosis (HP:0200114)2.13254101
121Abnormality of the odontoid process (HP:0003310)2.12780822
122Neonatal onset (HP:0003623)2.11193494
123Abnormality of alkaline phosphatase activity (HP:0004379)2.11153192
124Cerebral edema (HP:0002181)2.09534224
125Vacuolated lymphocytes (HP:0001922)2.09232711
126Male infertility (HP:0003251)2.08240298
127Elevated alkaline phosphatase (HP:0003155)2.07702621
128Abnormality of dentin (HP:0010299)2.07622745
129Mitral stenosis (HP:0001718)2.07556032
130Spontaneous abortion (HP:0005268)2.06090001
131Premature rupture of membranes (HP:0001788)2.05715946
132Nephrolithiasis (HP:0000787)2.05081966
133Cupped ribs (HP:0000887)2.04914359
134Distal lower limb muscle weakness (HP:0009053)2.03710943
135Striae distensae (HP:0001065)2.02602151
136Polyuria (HP:0000103)2.02070807
137Exercise-induced myalgia (HP:0003738)2.00265330
138Pustule (HP:0200039)1.99129353
139Lipoatrophy (HP:0100578)1.97017027
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.95483323
141Osteolytic defects of the hand bones (HP:0009699)1.95483323
142Hypochromic microcytic anemia (HP:0004840)1.95432569
143Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95241464
144Abnormality of renal excretion (HP:0011036)1.94202799
145Abnormality of the sella turcica (HP:0002679)1.93607385
146Abnormal gallbladder morphology (HP:0012437)1.93488273
147Epistaxis (HP:0000421)1.91908376
148Hyperphosphaturia (HP:0003109)1.91806589
149Abnormal respiratory motile cilium physiology (HP:0012261)1.91077336
150Round ear (HP:0100830)1.91003084
151Hypophosphatemic rickets (HP:0004912)1.90780424
152Brushfield spots (HP:0001088)1.90368790
153Increased CSF protein (HP:0002922)1.90241254
154Hyponatremia (HP:0002902)1.90153336
155Aneurysm (HP:0002617)1.89209609
156Hypertriglyceridemia (HP:0002155)1.88624782
157Abnormal cartilage morphology (HP:0002763)1.88436569
158Gingival bleeding (HP:0000225)1.86673112
159Papilledema (HP:0001085)1.86373324
160Cholecystitis (HP:0001082)1.86354286
161Abnormal gallbladder physiology (HP:0012438)1.86354286
162Cholelithiasis (HP:0001081)1.84555151
163Dynein arm defect of respiratory motile cilia (HP:0012255)1.84521206
164Absent/shortened dynein arms (HP:0200106)1.84521206
165Dilatation of the ascending aorta (HP:0005111)1.79850393
166Atelectasis (HP:0100750)1.79840920
167Hyperkalemia (HP:0002153)1.77363491
168Broad face (HP:0000283)1.76333738
169Zonular cataract (HP:0010920)1.76263446
170Abnormality of the nasal mucosa (HP:0000433)1.76155381
171Flared iliac wings (HP:0002869)1.75861651
172Bone cyst (HP:0012062)1.75434124
173Increased connective tissue (HP:0009025)1.75334954
174Prolonged neonatal jaundice (HP:0006579)1.74932033
175Long toe (HP:0010511)1.74777405
176Nasal polyposis (HP:0100582)1.74671722
177Myositis (HP:0100614)1.74590297
178Ventricular tachycardia (HP:0004756)1.73553507
179Ventricular arrhythmia (HP:0004308)1.72816676
180Toxemia of pregnancy (HP:0100603)1.70190065
181Mitral regurgitation (HP:0001653)1.69130178
182Abnormal delayed hypersensitivity skin test (HP:0002963)1.67705113
183Bronchiectasis (HP:0002110)1.67675020
184Aortic valve stenosis (HP:0001650)1.67202653
185Testicular atrophy (HP:0000029)1.66680414
186Stridor (HP:0010307)1.66206209
187Abnormal glucose tolerance (HP:0001952)1.65019404
188Upper limb amyotrophy (HP:0009129)1.63484244
189Distal upper limb amyotrophy (HP:0007149)1.63484244
190Neoplasm of the heart (HP:0100544)1.62578277
191Dilated cardiomyopathy (HP:0001644)1.61541092
192Absent frontal sinuses (HP:0002688)1.60697993
193Type 1 muscle fiber predominance (HP:0003803)1.60647884
194Spondylolisthesis (HP:0003302)1.59869732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.56006465
2ERN14.07051331
3WNK43.75386642
4INSRR3.58085798
5FGFR43.31350202
6SIK13.30177513
7WNK33.00548026
8TAOK32.91333397
9TNK22.43087888
10OXSR12.35084813
11PRKD22.28780832
12TRIB32.26512262
13PTK62.04747668
14PKN22.03034641
15LATS11.85715669
16TRPM71.84507276
17MST1R1.79250490
18EPHA21.77729460
19TGFBR21.75045775
20PIK3CA1.71647381
21MUSK1.69106183
22FRK1.64630723
23MAP4K21.61655481
24PIK3CG1.57008912
25MAPK151.54318239
26TYK21.53494775
27IRAK31.51391180
28MAPK111.42782614
29TAOK11.42499659
30EPHB11.33268034
31MAP3K31.32215238
32PTK2B1.29040761
33STK38L1.28951928
34STK381.24879201
35MAP2K41.22937147
36MAP2K31.21657461
37TTN1.18964261
38PHKG21.15868476
39PHKG11.15868476
40FLT31.14640944
41TBK11.12761589
42RIPK11.12579593
43JAK21.09998147
44ERBB21.09772547
45TIE11.08641086
46FES1.07401372
47STK391.07351935
48JAK31.06520704
49GRK71.05377198
50MYLK1.05151842
51JAK11.02454616
52ERBB41.02346482
53TRIM281.00526605
54ADRBK10.99920159
55MARK20.99584072
56MAP3K70.99249910
57CAMK1D0.98321904
58LRRK20.98315100
59PRKAA20.97687639
60FER0.97370387
61BTK0.95087732
62CDC42BPA0.93293042
63IKBKB0.92591105
64TESK10.90194924
65PRPF4B0.88197015
66MET0.87064889
67PDK30.85821899
68PDK40.85821899
69ABL20.84891304
70KDR0.84616948
71MAP3K130.83760420
72PTK20.82971387
73HIPK20.82960168
74NEK90.82598467
75DAPK20.81776487
76PRKD10.78473972
77MAP3K140.76073625
78GSK3A0.72634203
79MAPK40.72622990
80MAP2K20.71839054
81CAMK1G0.68678766
82SGK2230.66187003
83SGK4940.66187003
84PRKAA10.66180675
85SGK30.65398113
86PRKCE0.62786874
87ADRBK20.62763246
88VRK10.60273173
89PDK20.60148790
90GRK60.58439963
91ZAP700.58058871
92OBSCN0.57974477
93PRKACG0.57479698
94CSF1R0.55847482
95DYRK1B0.55583470
96ROCK10.55029785
97HCK0.54557356
98MAPK120.54495523
99STK100.54220522
100CSK0.54167522
101MAP3K60.54066622
102PDGFRB0.53325950
103PAK40.53268341
104IGF1R0.52104995
105DAPK30.51629967
106AKT30.51135551
107PINK10.50597676
108SGK20.50440482
109PRKCZ0.50389480
110BMX0.48281777
111GRK10.47828780
112CAMK10.47816183
113LCK0.47746489
114CDK60.46408300
115TEC0.45710684
116CAMK2D0.45589013
117MAP3K100.45249999
118MAP3K120.44796623
119ITK0.43734271
120GRK50.43721333
121CAMK40.43219642
122EPHA30.42971014
123STK30.42017405
124SYK0.41707576
125LYN0.41595672
126MAP4K10.41118603
127MAPK30.40655020
128PDPK10.40580997
129RPS6KB20.40467616
130MAPKAPK30.39834561
131MAP3K50.38560627
132PDK10.38358342
133MAPK70.37039748
134RET0.36093318
135MAP2K60.35286558
136IKBKE0.32708924
137CHUK0.31169735
138NUAK10.30801729
139EGFR0.29640253
140MAP3K20.28251863
141FGFR20.27340084
142WNK10.26642193
143MTOR0.25416628
144PAK30.25383623
145KIT0.25112337
146MAP3K110.24922273
147PRKCQ0.24212871
148PAK20.24053913
149BLK0.23998600
150PRKCA0.23441090
151RPS6KA20.23438943
152PRKCH0.21491446

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.79731317
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44107958
3Nitrogen metabolism_Homo sapiens_hsa009102.93365368
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86449345
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.75523657
6Tryptophan metabolism_Homo sapiens_hsa003802.75509410
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74986132
8Fatty acid degradation_Homo sapiens_hsa000712.67454327
9Butanoate metabolism_Homo sapiens_hsa006502.60853083
10Arginine biosynthesis_Homo sapiens_hsa002202.58857847
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55939704
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.50381740
13Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.42011508
14Propanoate metabolism_Homo sapiens_hsa006402.35263689
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31588524
16Complement and coagulation cascades_Homo sapiens_hsa046102.31182735
17Peroxisome_Homo sapiens_hsa041462.27158895
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11446629
19Fatty acid metabolism_Homo sapiens_hsa012121.98644087
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92048991
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.91382632
22PPAR signaling pathway_Homo sapiens_hsa033201.91198331
23Dilated cardiomyopathy_Homo sapiens_hsa054141.87633258
24beta-Alanine metabolism_Homo sapiens_hsa004101.82721733
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82610287
26Histidine metabolism_Homo sapiens_hsa003401.82151259
27Selenocompound metabolism_Homo sapiens_hsa004501.78808773
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.69768954
29Chemical carcinogenesis_Homo sapiens_hsa052041.67142523
30Sulfur metabolism_Homo sapiens_hsa009201.66681107
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63592434
32Staphylococcus aureus infection_Homo sapiens_hsa051501.62286403
33Pyruvate metabolism_Homo sapiens_hsa006201.61209723
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.58174244
35Bile secretion_Homo sapiens_hsa049761.55808078
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55347632
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51379009
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.47702156
39Starch and sucrose metabolism_Homo sapiens_hsa005001.47075298
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.45715234
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44847374
42Retinol metabolism_Homo sapiens_hsa008301.41541447
43Phenylalanine metabolism_Homo sapiens_hsa003601.40842976
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.39338461
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38982597
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.35512907
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32604712
48ECM-receptor interaction_Homo sapiens_hsa045121.32295093
49Platelet activation_Homo sapiens_hsa046111.31947000
50Caffeine metabolism_Homo sapiens_hsa002321.26604061
51Carbon metabolism_Homo sapiens_hsa012001.26348847
52Tyrosine metabolism_Homo sapiens_hsa003501.25021839
53ABC transporters_Homo sapiens_hsa020101.24960067
54Folate biosynthesis_Homo sapiens_hsa007901.24395094
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23716173
56Fatty acid elongation_Homo sapiens_hsa000621.23314645
57Focal adhesion_Homo sapiens_hsa045101.15601238
58Vitamin digestion and absorption_Homo sapiens_hsa049771.14958412
59Arginine and proline metabolism_Homo sapiens_hsa003301.12379941
60Lysine degradation_Homo sapiens_hsa003101.11824712
61Notch signaling pathway_Homo sapiens_hsa043301.11237213
62Biosynthesis of amino acids_Homo sapiens_hsa012301.10947420
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10838486
64Steroid biosynthesis_Homo sapiens_hsa001001.08877536
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.06447949
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05043437
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04484116
68Fat digestion and absorption_Homo sapiens_hsa049751.03847844
69Hematopoietic cell lineage_Homo sapiens_hsa046400.95698408
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92925890
71Malaria_Homo sapiens_hsa051440.92133975
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88715130
73Glutathione metabolism_Homo sapiens_hsa004800.85557207
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.83681906
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83349884
76Glycerolipid metabolism_Homo sapiens_hsa005610.80934478
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80218131
78Osteoclast differentiation_Homo sapiens_hsa043800.80153951
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79758112
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77176591
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76411536
82Vitamin B6 metabolism_Homo sapiens_hsa007500.74518691
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.73010338
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71676374
85Acute myeloid leukemia_Homo sapiens_hsa052210.70490869
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.70216436
87T cell receptor signaling pathway_Homo sapiens_hsa046600.70027063
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69124837
89Inositol phosphate metabolism_Homo sapiens_hsa005620.67026100
90Choline metabolism in cancer_Homo sapiens_hsa052310.66441236
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.63879892
92Renin secretion_Homo sapiens_hsa049240.63844644
93N-Glycan biosynthesis_Homo sapiens_hsa005100.63419705
94Pentose phosphate pathway_Homo sapiens_hsa000300.61780752
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57501453
96Sulfur relay system_Homo sapiens_hsa041220.56796073
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56009346
98Circadian rhythm_Homo sapiens_hsa047100.54776502
99Primary immunodeficiency_Homo sapiens_hsa053400.52978533
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50908218
101Pertussis_Homo sapiens_hsa051330.50487953
102B cell receptor signaling pathway_Homo sapiens_hsa046620.50300442
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50161167
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50136010
105Metabolic pathways_Homo sapiens_hsa011000.49298978
106One carbon pool by folate_Homo sapiens_hsa006700.47137866
107Pancreatic secretion_Homo sapiens_hsa049720.45944018
108Leishmaniasis_Homo sapiens_hsa051400.44628684
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44336444
110Fructose and mannose metabolism_Homo sapiens_hsa000510.44113425
111Galactose metabolism_Homo sapiens_hsa000520.43577355
112Ether lipid metabolism_Homo sapiens_hsa005650.41913882
113Salivary secretion_Homo sapiens_hsa049700.41237181
114mTOR signaling pathway_Homo sapiens_hsa041500.41193792
115Amoebiasis_Homo sapiens_hsa051460.41096587
116GnRH signaling pathway_Homo sapiens_hsa049120.39987726
117Prolactin signaling pathway_Homo sapiens_hsa049170.39294756
118Fatty acid biosynthesis_Homo sapiens_hsa000610.38445869
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38188921
120Insulin secretion_Homo sapiens_hsa049110.37312374
121Oxytocin signaling pathway_Homo sapiens_hsa049210.36952319
122Insulin resistance_Homo sapiens_hsa049310.35772136
123Other glycan degradation_Homo sapiens_hsa005110.35267847
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.31341521
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.26545293
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23739422
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22819494
128Prion diseases_Homo sapiens_hsa050200.21086903
129Lysosome_Homo sapiens_hsa041420.16366608
130Glucagon signaling pathway_Homo sapiens_hsa049220.14764932
131Protein digestion and absorption_Homo sapiens_hsa049740.14704097
132Mineral absorption_Homo sapiens_hsa049780.14010356
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11783803
134AMPK signaling pathway_Homo sapiens_hsa041520.06183768
135Renin-angiotensin system_Homo sapiens_hsa046140.05405337
136Linoleic acid metabolism_Homo sapiens_hsa005910.04259531
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.04235773
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.04211866
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04114297
140Thyroid hormone synthesis_Homo sapiens_hsa049180.02839172
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01105629
142Hepatitis C_Homo sapiens_hsa05160-0.1556337
143Type II diabetes mellitus_Homo sapiens_hsa04930-0.1397316
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1124851
145Insulin signaling pathway_Homo sapiens_hsa04910-0.1047677
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1046742
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0813782
148Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0265992
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0239300
150Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0238178
151Protein export_Homo sapiens_hsa03060-0.0178588

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