ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	respiratory chain complex IV assembly (GO:0008535)	4.37731691
2	protein complex biogenesis (GO:0070271)	4.00836291
3	cytochrome complex assembly (GO:0017004)	3.80068863
4	mitochondrial respiratory chain complex assembly (GO:0033108)	3.78103326
5	peptidyl-histidine modification (GO:0018202)	3.75726839
6	cardiac right ventricle morphogenesis (GO:0003215)	3.62419144
7	chaperone-mediated protein transport (GO:0072321)	3.58514368
8	Leydig cell differentiation (GO:0033327)	3.53459229
9	epithelial cilium movement (GO:0003351)	3.51253832
10	behavioral response to nicotine (GO:0035095)	3.50085196
11	epithelial cell fate commitment (GO:0072148)	3.36218535
12	NADH dehydrogenase complex assembly (GO:0010257)	3.33714147
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.33714147
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.33714147
15	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.30353698
16	glycerophospholipid catabolic process (GO:0046475)	3.28279018
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.22434951
18	diaphragm development (GO:0060539)	3.20884667
19	negative regulation of cAMP-mediated signaling (GO:0043951)	3.15082695
20	positive regulation of catecholamine secretion (GO:0033605)	3.09774507
21	regulation of cell proliferation involved in kidney development (GO:1901722)	3.08433032
22	protein insertion into membrane (GO:0051205)	3.05666431
23	spermatid development (GO:0007286)	3.04827039
24	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.04421305
25	regulation of male gonad development (GO:2000018)	3.00803728
26	nucleoside diphosphate catabolic process (GO:0009134)	3.00361277
27	keratinocyte development (GO:0003334)	2.98346164
28	short-term memory (GO:0007614)	2.96865393
29	seminiferous tubule development (GO:0072520)	2.94485462
30	parturition (GO:0007567)	2.93374169
31	basic amino acid transport (GO:0015802)	2.91393292
32	regulation of meiosis I (GO:0060631)	2.91029872
33	activation of protein kinase B activity (GO:0032148)	2.87904978
34	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.87382184
35	skeletal muscle organ development (GO:0060538)	2.85881226
36	genetic imprinting (GO:0071514)	2.84658263
37	positive regulation of male gonad development (GO:2000020)	2.82957787
38	nonmotile primary cilium assembly (GO:0035058)	2.82456784
39	inositol phosphate catabolic process (GO:0071545)	2.77327341
40	metanephric mesenchyme development (GO:0072075)	2.75489042
41	signal transduction involved in regulation of gene expression (GO:0023019)	2.73523142
42	cellular response to gonadotropin stimulus (GO:0071371)	2.73100708
43	maturation of 5.8S rRNA (GO:0000460)	2.72376768
44	postsynaptic membrane organization (GO:0001941)	2.70429461
45	sex determination (GO:0007530)	2.69336290
46	rRNA modification (GO:0000154)	2.68450740
47	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.68033644
48	regulation of hippo signaling (GO:0035330)	2.68017427
49	rRNA methylation (GO:0031167)	2.66224424
50	startle response (GO:0001964)	2.65718680
51	microtubule severing (GO:0051013)	2.63331084
52	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.63019821
53	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.62293426
54	substrate-independent telencephalic tangential migration (GO:0021826)	2.62293426
55	presynaptic membrane assembly (GO:0097105)	2.61636148
56	negative regulation of macrophage differentiation (GO:0045650)	2.60719639
57	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.60014350
58	DNA double-strand break processing (GO:0000729)	2.58309932
59	regulation of heat generation (GO:0031650)	2.57398476
60	water-soluble vitamin biosynthetic process (GO:0042364)	2.56050083
61	L-phenylalanine catabolic process (GO:0006559)	2.53814317
62	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.53814317
63	L-phenylalanine metabolic process (GO:0006558)	2.52219579
64	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.52219579
65	regulation of mitochondrial translation (GO:0070129)	2.51351509
66	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.50481710
67	cornea development in camera-type eye (GO:0061303)	2.49854421
68	glutathione derivative metabolic process (GO:1901685)	2.47870281
69	glutathione derivative biosynthetic process (GO:1901687)	2.47870281
70	TOR signaling (GO:0031929)	2.47543419
71	regulation of oxidative phosphorylation (GO:0002082)	2.46780859
72	mesenchymal to epithelial transition (GO:0060231)	2.46366485
73	inositol phosphate dephosphorylation (GO:0046855)	2.46299994
74	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.46299994
75	regulation of cellular respiration (GO:0043457)	2.45943684
76	kidney mesenchyme development (GO:0072074)	2.45696044
77	endocrine pancreas development (GO:0031018)	2.45692260
78	positive regulation of prostaglandin secretion (GO:0032308)	2.45569139
79	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.45286406
80	presynaptic membrane organization (GO:0097090)	2.43997070
81	glycosphingolipid biosynthetic process (GO:0006688)	2.43604239
82	atrial cardiac muscle cell action potential (GO:0086014)	2.43202521
83	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.42841321
84	protein localization to cilium (GO:0061512)	2.42819466
85	neuron cell-cell adhesion (GO:0007158)	2.41909598
86	inner mitochondrial membrane organization (GO:0007007)	2.41902249
87	proteasome assembly (GO:0043248)	2.41225734
88	zinc ion transmembrane transport (GO:0071577)	2.40481382
89	response to dietary excess (GO:0002021)	2.40192236
90	righting reflex (GO:0060013)	2.40077594
91	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.39136229
92	negative regulation of metanephros development (GO:0072217)	2.38696062
93	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.38305079
94	response to nitrosative stress (GO:0051409)	2.36690002
95	cilium movement (GO:0003341)	2.36348914
96	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.35816633
97	regulation of acrosome reaction (GO:0060046)	2.35498204
98	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.35214347
99	insulin secretion (GO:0030073)	2.34705281
100	multicellular organism reproduction (GO:0032504)	2.33765187

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.81526794
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.60103751
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.26446017
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.17247466
5	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.77310222
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.65711331
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.43932637
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.40904941
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.35098393
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.31179051
11	VDR_22108803_ChIP-Seq_LS180_Human	2.30734250
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.28925695
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.25849905
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.24019252
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.12054170
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.08598252
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.01204246
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00762474
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.99138024
20	EZH2_22144423_ChIP-Seq_EOC_Human	1.98323264
21	EWS_26573619_Chip-Seq_HEK293_Human	1.90222588
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.76941897
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.73920914
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.65435870
25	FUS_26573619_Chip-Seq_HEK293_Human	1.55481083
26	P300_19829295_ChIP-Seq_ESCs_Human	1.53956627
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53547810
28	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.52535642
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.49922280
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.43630266
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43189396
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.43068679
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.42436627
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.40241346
35	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39936566
36	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.38042552
37	AR_25329375_ChIP-Seq_VCAP_Human	1.34270345
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31711594
39	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.31268458
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.31243207
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30547780
42	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.30443155
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27476431
44	MYC_19829295_ChIP-Seq_ESCs_Human	1.26361796
45	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.25535164
46	NCOR_22424771_ChIP-Seq_293T_Human	1.21980321
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.21408911
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20235811
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.20235811
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20175483
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.18203069
52	SMAD4_21799915_ChIP-Seq_A2780_Human	1.17505746
53	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17451706
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14648211
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13433301
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13090622
57	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12659060
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.11826986
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09509778
60	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.09063792
61	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.07446038
62	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06765118
63	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.05878206
64	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.04939892
65	* ERA_21632823_ChIP-Seq_H3396_Human	1.04893436
66	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.04692008
67	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.04319170
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03715301
69	TBL1_22424771_ChIP-Seq_293T_Human	1.02593459
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.02551524
71	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01869852
72	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.00139806
73	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.99771233
74	AHR_22903824_ChIP-Seq_MCF-7_Human	0.99441065
75	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.98627218
76	PHF8_20622853_ChIP-Seq_HELA_Human	0.98409819
77	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.98319641
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97165463
79	TAF15_26573619_Chip-Seq_HEK293_Human	0.95928166
80	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94214866
81	TCF4_23295773_ChIP-Seq_U87_Human	0.92914890
82	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.92766093
83	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.92762175
84	NFYB_21822215_ChIP-Seq_K562_Human	0.92598553
85	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92011082
86	SOX2_19829295_ChIP-Seq_ESCs_Human	0.92011082
87	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.91653924
88	CDX2_22108803_ChIP-Seq_LS180_Human	0.91347437
89	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.91285594
90	STAT3_23295773_ChIP-Seq_U87_Human	0.90082270
91	NFYA_21822215_ChIP-Seq_K562_Human	0.90031925
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.89240779
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.89221016
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.88373255
95	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.88158098
96	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.87799587
97	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.87424862
98	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.87230931
99	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.85996386
100	AR_21572438_ChIP-Seq_LNCaP_Human	0.84574687

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.15159485
2	MP0003315_abnormal_perineum_morphology	3.44241707
3	MP0008995_early_reproductive_senescence	3.13698320
4	MP0003123_paternal_imprinting	2.92602923
5	MP0002160_abnormal_reproductive_system	2.80115678
6	MP0002254_reproductive_system_inflammat	2.80110229
7	MP0001986_abnormal_taste_sensitivity	2.78245802
8	MP0002736_abnormal_nociception_after	2.58434205
9	MP0001968_abnormal_touch/_nociception	2.44275625
10	MP0000647_abnormal_sebaceous_gland	2.41194586
11	MP0005379_endocrine/exocrine_gland_phen	2.41051557
12	MP0008877_abnormal_DNA_methylation	2.22348886
13	MP0002837_dystrophic_cardiac_calcinosis	2.20778090
14	MP0005410_abnormal_fertilization	2.16385242
15	MP0002163_abnormal_gland_morphology	2.14832218
16	MP0000427_abnormal_hair_cycle	2.10315204
17	MP0005187_abnormal_penis_morphology	2.04433355
18	MP0002909_abnormal_adrenal_gland	2.04127645
19	MP0010386_abnormal_urinary_bladder	1.97140734
20	MP0000639_abnormal_adrenal_gland	1.87853033
21	MP0001919_abnormal_reproductive_system	1.85946725
22	MP0003195_calcinosis	1.85036013
23	MP0005389_reproductive_system_phenotype	1.81930482
24	MP0001188_hyperpigmentation	1.79710686
25	MP0003136_yellow_coat_color	1.74283658
26	MP0002876_abnormal_thyroid_physiology	1.67959835
27	MP0002822_catalepsy	1.58367867
28	MP0002210_abnormal_sex_determination	1.56849117
29	MP0005423_abnormal_somatic_nervous	1.50605876
30	MP0003567_abnormal_fetal_cardiomyocyte	1.49957366
31	MP0003119_abnormal_digestive_system	1.49447961
32	MP0000631_abnormal_neuroendocrine_gland	1.46461649
33	MP0004885_abnormal_endolymph	1.46336809
34	MP0003121_genomic_imprinting	1.45461283
35	MP0005646_abnormal_pituitary_gland	1.40237653
36	MP0009745_abnormal_behavioral_response	1.34758138
37	MP0009379_abnormal_foot_pigmentation	1.33519705
38	MP0002272_abnormal_nervous_system	1.32581552
39	MP0000013_abnormal_adipose_tissue	1.32371705
40	MP0001929_abnormal_gametogenesis	1.32310461
41	MP0005645_abnormal_hypothalamus_physiol	1.31622106
42	MP0003698_abnormal_male_reproductive	1.29219264
43	MP0001905_abnormal_dopamine_level	1.27319471
44	MP0001145_abnormal_male_reproductive	1.23574402
45	MP0000653_abnormal_sex_gland	1.15881741
46	MP0002127_abnormal_cardiovascular_syste	1.08353704
47	MP0009384_cardiac_valve_regurgitation	1.08342113
48	MP0002751_abnormal_autonomic_nervous	1.07699749
49	MP0002184_abnormal_innervation	1.04781729
50	MP0002638_abnormal_pupillary_reflex	1.03607373
51	MP0006292_abnormal_olfactory_placode	1.02774488
52	MP0002735_abnormal_chemical_nociception	1.01277378
53	MP0001944_abnormal_pancreas_morphology	1.00263134
54	MP0003283_abnormal_digestive_organ	0.99803664
55	MP0009046_muscle_twitch	0.98651585
56	MP0001486_abnormal_startle_reflex	0.97722304
57	MP0000470_abnormal_stomach_morphology	0.97431125
58	MP0005551_abnormal_eye_electrophysiolog	0.97315750
59	MP0001485_abnormal_pinna_reflex	0.96984206
60	MP0008875_abnormal_xenobiotic_pharmacok	0.96747958
61	MP0002653_abnormal_ependyma_morphology	0.96703012
62	MP0006072_abnormal_retinal_apoptosis	0.96465212
63	MP0002557_abnormal_social/conspecific_i	0.96333632
64	MP0003122_maternal_imprinting	0.95361842
65	MP0002734_abnormal_mechanical_nocicepti	0.95148351
66	MP0005220_abnormal_exocrine_pancreas	0.94467950
67	MP0002938_white_spotting	0.93438221
68	MP0002233_abnormal_nose_morphology	0.90121671
69	MP0003936_abnormal_reproductive_system	0.89687463
70	MP0004019_abnormal_vitamin_homeostasis	0.89639461
71	MP0000383_abnormal_hair_follicle	0.88786137
72	MP0003786_premature_aging	0.86579193
73	MP0003880_abnormal_central_pattern	0.86093025
74	MP0001346_abnormal_lacrimal_gland	0.85912239
75	MP0002693_abnormal_pancreas_physiology	0.85836578
76	MP0002064_seizures	0.85044153
77	MP0002733_abnormal_thermal_nociception	0.84676478
78	MP0001756_abnormal_urination	0.84236619
79	MP0003941_abnormal_skin_development	0.83206367
80	MP0000049_abnormal_middle_ear	0.82800518
81	MP0005647_abnormal_sex_gland	0.82017591
82	MP0008872_abnormal_physiological_respon	0.81195337
83	MP0002090_abnormal_vision	0.80969094
84	MP0008058_abnormal_DNA_repair	0.80890334
85	MP0002161_abnormal_fertility/fecundity	0.80734912
86	MP0003635_abnormal_synaptic_transmissio	0.80682162
87	MP0001970_abnormal_pain_threshold	0.80274047
88	MP0003868_abnormal_feces_composition	0.80200112
89	MP0006276_abnormal_autonomic_nervous	0.80182452
90	MP0002102_abnormal_ear_morphology	0.79930461
91	MP0003646_muscle_fatigue	0.79601084
92	MP0004133_heterotaxia	0.77524008
93	MP0002697_abnormal_eye_size	0.76669897
94	MP0005365_abnormal_bile_salt	0.76096218
95	MP0004085_abnormal_heartbeat	0.75459124
96	MP0001529_abnormal_vocalization	0.74887873
97	MP0003186_abnormal_redox_activity	0.73794769
98	MP0003693_abnormal_embryo_hatching	0.72119006
99	MP0002277_abnormal_respiratory_mucosa	0.71693423
100	MP0004043_abnormal_pH_regulation	0.70493192

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal pancreas size (HP:0012094)	4.23969522
2	Hepatoblastoma (HP:0002884)	4.05692270
3	Sex reversal (HP:0012245)	3.87692142
4	Abnormal sex determination (HP:0012244)	3.87692142
5	Gonadal dysgenesis (HP:0000133)	3.84032185
6	Germ cell neoplasia (HP:0100728)	3.55957375
7	Neoplasm of the adrenal cortex (HP:0100641)	3.28724121
8	Male pseudohermaphroditism (HP:0000037)	3.21670531
9	True hermaphroditism (HP:0010459)	3.17560392
10	Renal Fanconi syndrome (HP:0001994)	3.10878004
11	Testicular neoplasm (HP:0010788)	2.96850669
12	Lipid accumulation in hepatocytes (HP:0006561)	2.69857337
13	Osteomalacia (HP:0002749)	2.69184781
14	Hypoplasia of the uterus (HP:0000013)	2.68577698
15	Abnormality of midbrain morphology (HP:0002418)	2.66050408
16	Molar tooth sign on MRI (HP:0002419)	2.66050408
17	Hyperventilation (HP:0002883)	2.63715620
18	Increased hepatocellular lipid droplets (HP:0006565)	2.60513296
19	Increased circulating renin level (HP:0000848)	2.57575149
20	Aplasia/hypoplasia of the uterus (HP:0008684)	2.51016361
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.48336163
22	Absent/shortened dynein arms (HP:0200106)	2.48336163
23	Congenital sensorineural hearing impairment (HP:0008527)	2.48253729
24	Abnormality of urine glucose concentration (HP:0011016)	2.46645155
25	Glycosuria (HP:0003076)	2.46645155
26	Acute necrotizing encephalopathy (HP:0006965)	2.43715840
27	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.42450140
28	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.42450140
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.41675075
30	Abnormal drinking behavior (HP:0030082)	2.41350196
31	Polydipsia (HP:0001959)	2.41350196
32	Hyperphosphaturia (HP:0003109)	2.38857314
33	Reduced antithrombin III activity (HP:0001976)	2.38572218
34	Metaphyseal dysplasia (HP:0100255)	2.38519634
35	Abnormality of renal resorption (HP:0011038)	2.36996639
36	Hypomagnesemia (HP:0002917)	2.30456172
37	Pancreatic fibrosis (HP:0100732)	2.30290388
38	Mitochondrial inheritance (HP:0001427)	2.29123442
39	Neonatal hypoglycemia (HP:0001998)	2.28350917
40	Intestinal atresia (HP:0011100)	2.22367706
41	Abnormality of the corticospinal tract (HP:0002492)	2.21805851
42	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.20725065
43	Progressive inability to walk (HP:0002505)	2.14236915
44	Abnormal urine phosphate concentration (HP:0012599)	2.13673620
45	Methylmalonic acidemia (HP:0002912)	2.13161722
46	Hypophosphatemic rickets (HP:0004912)	2.12284617
47	Hyperinsulinemic hypoglycemia (HP:0000825)	2.09865422
48	Abnormality of the labia minora (HP:0012880)	2.07409916
49	Urinary urgency (HP:0000012)	2.05664630
50	Absent eyebrow (HP:0002223)	2.05531001
51	Progressive macrocephaly (HP:0004481)	2.04994129
52	Acute encephalopathy (HP:0006846)	2.04976383
53	Concave nail (HP:0001598)	2.04824414
54	Increased CSF lactate (HP:0002490)	2.02515931
55	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.02034530
56	Adrenal hypoplasia (HP:0000835)	2.01605319
57	Tetany (HP:0001281)	1.99275401
58	Congenital stationary night blindness (HP:0007642)	1.98438319
59	Agitation (HP:0000713)	1.97917088
60	Enlarged kidneys (HP:0000105)	1.97553339
61	Mesangial abnormality (HP:0001966)	1.96676211
62	Median cleft lip (HP:0000161)	1.96432992
63	Abnormal mitochondria in muscle tissue (HP:0008316)	1.96414056
64	Type I diabetes mellitus (HP:0100651)	1.91009663
65	Preaxial foot polydactyly (HP:0001841)	1.90204964
66	Female pseudohermaphroditism (HP:0010458)	1.88054890
67	Pancreatic cysts (HP:0001737)	1.87931396
68	Abnormal protein glycosylation (HP:0012346)	1.85876322
69	Abnormal glycosylation (HP:0012345)	1.85876322
70	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.85876322
71	Abnormal protein N-linked glycosylation (HP:0012347)	1.85876322
72	Diastasis recti (HP:0001540)	1.84806765
73	Abnormality of the pancreatic islet cells (HP:0006476)	1.84098630
74	Abnormality of endocrine pancreas physiology (HP:0012093)	1.84098630
75	Methylmalonic aciduria (HP:0012120)	1.81376414
76	Abnormality of magnesium homeostasis (HP:0004921)	1.81170315
77	Abnormality of renal excretion (HP:0011036)	1.81120581
78	Polyuria (HP:0000103)	1.80600953
79	Absence seizures (HP:0002121)	1.80235295
80	Pendular nystagmus (HP:0012043)	1.78070088
81	Premature ovarian failure (HP:0008209)	1.77882207
82	Neoplasm of the oral cavity (HP:0100649)	1.75474536
83	Hypoplastic left heart (HP:0004383)	1.75433571
84	Dialeptic seizures (HP:0011146)	1.74575112
85	Transposition of the great arteries (HP:0001669)	1.74505430
86	Abnormal connection of the cardiac segments (HP:0011545)	1.74505430
87	Abnormal ventriculo-arterial connection (HP:0011563)	1.74505430
88	Inability to walk (HP:0002540)	1.74411872
89	Anomalous pulmonary venous return (HP:0010772)	1.73902752
90	Abnormal urine output (HP:0012590)	1.73385313
91	Broad-based gait (HP:0002136)	1.73237701
92	Cerebellar dysplasia (HP:0007033)	1.72792134
93	Absent speech (HP:0001344)	1.71875255
94	Type I transferrin isoform profile (HP:0003642)	1.70518457
95	Type II lissencephaly (HP:0007260)	1.70400005
96	Hyperglycemia (HP:0003074)	1.69451003
97	Chronic hepatic failure (HP:0100626)	1.67336656
98	Scrotal hypoplasia (HP:0000046)	1.67231767
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.66551702
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.66551702

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.86891187
2	PINK1	4.02925263
3	OXSR1	3.20762579
4	STK39	3.06345578
5	CASK	2.95903153
6	WNK4	2.84970328
7	GRK1	2.64586750
8	ZAK	2.49672815
9	MUSK	2.46469232
10	NUAK1	2.35734901
11	STK16	2.32776076
12	MAP2K7	2.25277804
13	TLK1	2.16775387
14	MAP3K4	2.02085274
15	ADRBK2	1.81778522
16	TNIK	1.57529167
17	WNK3	1.57473634
18	PHKG1	1.49195128
19	PHKG2	1.49195128
20	DYRK3	1.49005571
21	NLK	1.42155351
22	MAPK13	1.36658077
23	MARK3	1.35505846
24	IRAK2	1.34077451
25	SGK494	1.29831481
26	SGK223	1.29831481
27	STK38L	1.22807326
28	CSNK1G1	1.19798165
29	CDK3	1.19406070
30	IRAK1	1.16673547
31	PLK2	1.16375149
32	PAK3	1.15058517
33	DYRK2	1.11835305
34	MAP4K2	1.09350305
35	CSNK1G3	1.09198428
36	VRK2	1.08403912
37	PRKCG	1.02489722
38	PLK4	1.01729857
39	CSNK1G2	0.99342382
40	DMPK	0.96033809
41	SGK2	0.95328400
42	PBK	0.95105736
43	PRKCE	0.93231998
44	STK38	0.93096278
45	CAMK2A	0.87803981
46	NME1	0.87622197
47	CDC42BPA	0.84957945
48	DAPK2	0.83723595
49	NEK2	0.82986079
50	AKT3	0.81116907
51	VRK1	0.79321052
52	RPS6KA5	0.78587803
53	MAP3K9	0.75282486
54	EPHA4	0.69681257
55	CAMKK2	0.68738298
56	TRIM28	0.67294953
57	INSRR	0.66097716
58	RPS6KA4	0.63609040
59	STK4	0.62291425
60	LATS2	0.62260695
61	TAF1	0.61155484
62	LMTK2	0.59668174
63	MYLK	0.58117931
64	PRKCI	0.57321385
65	PLK1	0.56666990
66	PRKACA	0.56194129
67	STK11	0.56191387
68	MAP2K6	0.55825055
69	MKNK2	0.54218110
70	RPS6KA2	0.53983084
71	CAMK2D	0.53667743
72	CSNK1A1L	0.53418749
73	CSNK1E	0.53269707
74	TIE1	0.53218011
75	PAK1	0.52717196
76	EIF2AK3	0.51490048
77	BMPR1B	0.49514637
78	PRKAA1	0.49337716
79	ROCK1	0.48115743
80	CAMK2G	0.46033034
81	CAMK2B	0.45687657
82	NME2	0.45181024
83	AURKA	0.44618023
84	ACVR1B	0.44453291
85	CAMK1	0.43572758
86	ADRBK1	0.43541791
87	RPS6KB2	0.43050362
88	MAPK15	0.42006391
89	CSNK1A1	0.40128048
90	PKN1	0.39996151
91	MAPKAPK5	0.39945786
92	CAMK4	0.39915754
93	STK3	0.38812765
94	RPS6KB1	0.38538593
95	PRKDC	0.38272055
96	LATS1	0.37802190
97	NTRK3	0.36714763
98	BCR	0.35255573
99	HIPK2	0.35093523
100	SGK1	0.33898849

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.54429652
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.25654603
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.73352057
4	Protein export_Homo sapiens_hsa03060	2.47957421
5	Folate biosynthesis_Homo sapiens_hsa00790	2.38239064
6	RNA polymerase_Homo sapiens_hsa03020	2.35115808
7	Collecting duct acid secretion_Homo sapiens_hsa04966	2.32773950
8	Parkinsons disease_Homo sapiens_hsa05012	2.24114603
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.16657654
10	Ribosome_Homo sapiens_hsa03010	2.08144858
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.02368156
12	Cardiac muscle contraction_Homo sapiens_hsa04260	1.84762827
13	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.76730031
14	Huntingtons disease_Homo sapiens_hsa05016	1.76150143
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.75814124
16	Regulation of autophagy_Homo sapiens_hsa04140	1.73092666
17	Basal transcription factors_Homo sapiens_hsa03022	1.67394634
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.66598153
19	Phototransduction_Homo sapiens_hsa04744	1.57322548
20	Glutathione metabolism_Homo sapiens_hsa00480	1.57179237
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50270552
22	Insulin secretion_Homo sapiens_hsa04911	1.49326676
23	Alzheimers disease_Homo sapiens_hsa05010	1.48580055
24	Butanoate metabolism_Homo sapiens_hsa00650	1.45165264
25	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.39957085
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.39614633
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.33411381
28	Taste transduction_Homo sapiens_hsa04742	1.28455816
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25572511
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23630651
31	Nicotine addiction_Homo sapiens_hsa05033	1.19606375
32	Fatty acid elongation_Homo sapiens_hsa00062	1.18514603
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.17586911
34	Purine metabolism_Homo sapiens_hsa00230	1.17092267
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.15707081
36	Olfactory transduction_Homo sapiens_hsa04740	1.10010415
37	RNA degradation_Homo sapiens_hsa03018	1.06499308
38	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.02870663
39	Peroxisome_Homo sapiens_hsa04146	1.01737063
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.01545910
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01480130
42	Propanoate metabolism_Homo sapiens_hsa00640	0.99519065
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95178073
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95095729
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.94034886
46	Homologous recombination_Homo sapiens_hsa03440	0.93323713
47	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.92168928
48	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.91636053
49	Mineral absorption_Homo sapiens_hsa04978	0.90660226
50	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.90605983
51	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.85677765
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83606508
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.83564590
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.83299163
55	Metabolic pathways_Homo sapiens_hsa01100	0.80729576
56	Sulfur metabolism_Homo sapiens_hsa00920	0.79672320
57	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.78875993
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.78431780
59	RNA transport_Homo sapiens_hsa03013	0.76821526
60	Sphingolipid metabolism_Homo sapiens_hsa00600	0.76682636
61	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.76521833
62	Vibrio cholerae infection_Homo sapiens_hsa05110	0.74609766
63	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.72727873
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.70438399
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66126793
66	Morphine addiction_Homo sapiens_hsa05032	0.65878787
67	Oocyte meiosis_Homo sapiens_hsa04114	0.64592187
68	Renin secretion_Homo sapiens_hsa04924	0.59380775
69	Gap junction_Homo sapiens_hsa04540	0.59059508
70	GABAergic synapse_Homo sapiens_hsa04727	0.58425153
71	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.57632328
72	Arginine biosynthesis_Homo sapiens_hsa00220	0.57377075
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57243032
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.57116915
75	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.56151580
76	Nitrogen metabolism_Homo sapiens_hsa00910	0.55597414
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54623892
78	Serotonergic synapse_Homo sapiens_hsa04726	0.53826191
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52205139
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51819355
81	Dopaminergic synapse_Homo sapiens_hsa04728	0.50618036
82	Type II diabetes mellitus_Homo sapiens_hsa04930	0.47090104
83	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.46770629
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46322794
85	Retinol metabolism_Homo sapiens_hsa00830	0.45304239
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45196073
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.44657893
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.42967496
89	Pancreatic secretion_Homo sapiens_hsa04972	0.42957411
90	Proteasome_Homo sapiens_hsa03050	0.42752386
91	Cocaine addiction_Homo sapiens_hsa05030	0.41254718
92	Circadian entrainment_Homo sapiens_hsa04713	0.41087493
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.40933610
94	Lysine degradation_Homo sapiens_hsa00310	0.40534567
95	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40304185
96	Mismatch repair_Homo sapiens_hsa03430	0.39085357
97	Axon guidance_Homo sapiens_hsa04360	0.38430278
98	Salivary secretion_Homo sapiens_hsa04970	0.37983742
99	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.36843983
100	Amphetamine addiction_Homo sapiens_hsa05031	0.35306007

PYY2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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