PZP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)8.72720291
2cAMP catabolic process (GO:0006198)8.31192998
3protein prenylation (GO:0018342)7.91626325
4prenylation (GO:0097354)7.91626325
5regulation of centriole replication (GO:0046599)7.79229809
6cellular response to epinephrine stimulus (GO:0071872)7.60158032
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.55167268
8L-phenylalanine catabolic process (GO:0006559)7.55167268
9negative regulation of complement activation (GO:0045916)7.48504787
10citrulline biosynthetic process (GO:0019240)7.41552847
11midgut development (GO:0007494)7.32010815
12cyclic nucleotide catabolic process (GO:0009214)7.27064830
13L-phenylalanine metabolic process (GO:0006558)7.20105604
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.20105604
15cilium or flagellum-dependent cell motility (GO:0001539)7.14049828
16negative regulation of humoral immune response (GO:0002921)7.05447613
17pericardium development (GO:0060039)7.02523030
18hepatocyte differentiation (GO:0070365)6.88547380
19aromatic amino acid family catabolic process (GO:0009074)6.78835985
20positive regulation of odontogenesis (GO:0042482)6.69886653
21regulation of cardiac muscle cell contraction (GO:0086004)6.68898414
22regulation of cell communication by electrical coupling (GO:0010649)6.44426586
23response to epinephrine (GO:0071871)6.40550752
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.28544640
25axonemal dynein complex assembly (GO:0070286)6.24763028
26tryptophan catabolic process (GO:0006569)6.13739188
27indole-containing compound catabolic process (GO:0042436)6.13739188
28indolalkylamine catabolic process (GO:0046218)6.13739188
29negative regulation of immunoglobulin mediated immune response (GO:0002890)6.04446191
30negative regulation of B cell mediated immunity (GO:0002713)6.04446191
31kynurenine metabolic process (GO:0070189)6.02866672
32bile acid biosynthetic process (GO:0006699)5.93046794
33tryptophan metabolic process (GO:0006568)5.77517743
34glyoxylate metabolic process (GO:0046487)5.75755464
35negative regulation of fibrinolysis (GO:0051918)5.74736577
36regulation of interleukin-5 production (GO:0032674)5.71370166
37Rap protein signal transduction (GO:0032486)5.71246778
38urea metabolic process (GO:0019627)5.70529730
39urea cycle (GO:0000050)5.70529730
40alpha-linolenic acid metabolic process (GO:0036109)5.64737319
41regulation of protein activation cascade (GO:2000257)5.55855923
42complement activation, alternative pathway (GO:0006957)5.54994673
43regulation of fibrinolysis (GO:0051917)5.54351525
44high-density lipoprotein particle remodeling (GO:0034375)5.51908166
45peptidyl-glutamic acid carboxylation (GO:0017187)5.47859634
46protein carboxylation (GO:0018214)5.47859634
47iron ion import (GO:0097286)5.43918893
48cysteine metabolic process (GO:0006534)5.37409510
49sulfur amino acid catabolic process (GO:0000098)5.28423161
50nitrogen cycle metabolic process (GO:0071941)5.23852293
51citrulline metabolic process (GO:0000052)5.23092243
52regulation of complement activation (GO:0030449)5.16382623
53atrioventricular valve morphogenesis (GO:0003181)5.15136436
54regulation of actin filament-based movement (GO:1903115)5.14459440
55serine family amino acid catabolic process (GO:0009071)5.13693913
56regulation of Wnt signaling pathway involved in heart development (GO:0003307)5.13043934
57bile acid metabolic process (GO:0008206)5.11518047
58motile cilium assembly (GO:0044458)5.08386430
59monoubiquitinated protein deubiquitination (GO:0035520)5.00375753
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.99619914
61negative regulation of hormone biosynthetic process (GO:0032353)4.99599667
62aromatic amino acid family metabolic process (GO:0009072)4.92470981
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86410998
64reverse cholesterol transport (GO:0043691)4.85074448
65cilium movement (GO:0003341)4.84937583
66homocysteine metabolic process (GO:0050667)4.82868736
67regulation of cholesterol esterification (GO:0010872)4.80486975
68S-adenosylmethionine metabolic process (GO:0046500)4.79969590
69tyrosine metabolic process (GO:0006570)4.78774997
70establishment of apical/basal cell polarity (GO:0035089)4.78306806
71negative regulation of peptidyl-serine phosphorylation (GO:0033137)4.78084742
72protein-lipid complex remodeling (GO:0034368)4.77958764
73macromolecular complex remodeling (GO:0034367)4.77958764
74plasma lipoprotein particle remodeling (GO:0034369)4.77958764
75regulation of centrosome duplication (GO:0010824)4.76919308
76response to growth hormone (GO:0060416)4.75385575
77regulation of triglyceride catabolic process (GO:0010896)4.73897387
78alpha-amino acid catabolic process (GO:1901606)4.63589193
79amino-acid betaine metabolic process (GO:0006577)4.62136551
80triglyceride homeostasis (GO:0070328)4.60478605
81acylglycerol homeostasis (GO:0055090)4.60478605
82lysine metabolic process (GO:0006553)4.57132726
83lysine catabolic process (GO:0006554)4.57132726
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.51874931
85regulation of glucocorticoid metabolic process (GO:0031943)4.50824124
86negative regulation of cholesterol transport (GO:0032375)4.50668018
87negative regulation of sterol transport (GO:0032372)4.50668018
88phospholipid efflux (GO:0033700)4.49752511
89positive regulation of p38MAPK cascade (GO:1900745)4.47898463
90bile acid and bile salt transport (GO:0015721)4.47204872
91negative regulation of hormone metabolic process (GO:0032351)4.46430657
92cellular ketone body metabolic process (GO:0046950)4.46068476
93glycine metabolic process (GO:0006544)4.43855182
94response to dexamethasone (GO:0071548)4.42275463
95imidazole-containing compound metabolic process (GO:0052803)4.39857160
96plasma lipoprotein particle clearance (GO:0034381)4.39088086
97pathway-restricted SMAD protein phosphorylation (GO:0060389)4.36406404
98indolalkylamine metabolic process (GO:0006586)4.34388362
99coenzyme catabolic process (GO:0009109)4.32542309
100cellular glucuronidation (GO:0052695)4.28915940
101glutamate metabolic process (GO:0006536)4.25960643
102cholesterol efflux (GO:0033344)4.25722570
103cellular amino acid catabolic process (GO:0009063)4.25272236
104cellular biogenic amine catabolic process (GO:0042402)4.25239871
105amine catabolic process (GO:0009310)4.25239871
106adrenergic receptor signaling pathway (GO:0071875)4.24812578
107nuclear pore complex assembly (GO:0051292)4.22237284
108serine family amino acid metabolic process (GO:0009069)4.17853017
109response to food (GO:0032094)4.16186723
110low-density lipoprotein particle remodeling (GO:0034374)4.12566368
111benzene-containing compound metabolic process (GO:0042537)4.09956448
112fibrinolysis (GO:0042730)4.09927561
113positive regulation of osteoblast proliferation (GO:0033690)4.07988403
114ethanol oxidation (GO:0006069)4.07340683
115dicarboxylic acid biosynthetic process (GO:0043650)4.03938552
116cellular modified amino acid catabolic process (GO:0042219)4.03501663
117establishment or maintenance of monopolar cell polarity (GO:0061339)4.02901650
118establishment of monopolar cell polarity (GO:0061162)4.02901650
119serine family amino acid biosynthetic process (GO:0009070)4.02072634
120plasma lipoprotein particle assembly (GO:0034377)4.01849496
121regulation of steroid hormone biosynthetic process (GO:0090030)3.98502795
122arginine metabolic process (GO:0006525)3.97323078
123aldehyde catabolic process (GO:0046185)3.95856684
124blood coagulation, intrinsic pathway (GO:0007597)3.94956508
125drug catabolic process (GO:0042737)3.90593620
126positive regulation of vascular permeability (GO:0043117)3.90029161
127long term synaptic depression (GO:0060292)3.88358705
128ketone body metabolic process (GO:1902224)3.86083191
129complement activation, classical pathway (GO:0006958)3.85363850
130epithelial cilium movement (GO:0003351)3.84362741
131complement activation (GO:0006956)3.83876899
132protein activation cascade (GO:0072376)3.83748890
133phospholipid homeostasis (GO:0055091)3.83021364
134regulation of centrosome cycle (GO:0046605)3.81815527
135glucuronate metabolic process (GO:0019585)3.80252784
136uronic acid metabolic process (GO:0006063)3.80252784
137regulation of bile acid biosynthetic process (GO:0070857)3.78618962
138very-low-density lipoprotein particle assembly (GO:0034379)3.78257322
139cofactor catabolic process (GO:0051187)3.77701915
140cholesterol homeostasis (GO:0042632)3.76584914
141positive regulation of lipid catabolic process (GO:0050996)3.74014775
142cornea development in camera-type eye (GO:0061303)3.72394098
143positive regulation of lipoprotein lipase activity (GO:0051006)3.72265332
144positive regulation of triglyceride lipase activity (GO:0061365)3.72265332
145regulation of cholesterol homeostasis (GO:2000188)3.72245720
146carboxylic acid catabolic process (GO:0046395)3.71668305
147organic acid catabolic process (GO:0016054)3.71668305
148negative regulation of protein activation cascade (GO:2000258)3.70508780
149sterol homeostasis (GO:0055092)3.70327710
150negative regulation of lipase activity (GO:0060192)3.66998103
151cytolysis (GO:0019835)3.64085174
152plasma lipoprotein particle organization (GO:0071827)3.63880569
153acetyl-CoA metabolic process (GO:0006084)3.63853419
154short-chain fatty acid metabolic process (GO:0046459)3.62969576
155acute-phase response (GO:0006953)3.61876983
156protein-lipid complex assembly (GO:0065005)3.60199238
157peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.58349965
158protein destabilization (GO:0031648)3.56897772
159polarized epithelial cell differentiation (GO:0030859)3.51731181
160dorsal/ventral axis specification (GO:0009950)3.50788013
161positive regulation of astrocyte differentiation (GO:0048711)3.49994228
162establishment of endothelial barrier (GO:0061028)3.48304853
163renal absorption (GO:0070293)3.43330673
164nuclear pore organization (GO:0006999)3.39253462
165axoneme assembly (GO:0035082)3.38290172
166cAMP metabolic process (GO:0046058)3.35592797
167cAMP-mediated signaling (GO:0019933)3.26200112
168negative regulation of gluconeogenesis (GO:0045721)3.25747446
169embryonic body morphogenesis (GO:0010172)3.19305257
170endocardial cushion morphogenesis (GO:0003203)3.18795716
171regulation of p38MAPK cascade (GO:1900744)3.17540611
172pore complex assembly (GO:0046931)3.15550208
173glycogen catabolic process (GO:0005980)3.08615918
174sulfur amino acid metabolic process (GO:0000096)3.08196898
175cellular response to monoamine stimulus (GO:0071868)3.03846461
176cellular response to catecholamine stimulus (GO:0071870)3.03846461
177nodal signaling pathway (GO:0038092)3.02555359
178negative regulation of heart contraction (GO:0045822)2.95232254
179glucan catabolic process (GO:0009251)2.91743733
180import into cell (GO:0098657)2.90330798
181positive regulation of heart rate (GO:0010460)2.89453535
182cellular response to cAMP (GO:0071320)2.79500734
183triglyceride catabolic process (GO:0019433)2.78378691
184cellular polysaccharide catabolic process (GO:0044247)2.74652483
185glutamine metabolic process (GO:0006541)2.70488150
186cell proliferation involved in kidney development (GO:0072111)2.70074402
187keratinocyte development (GO:0003334)2.69599581
188ER overload response (GO:0006983)2.68111609
189centriole assembly (GO:0098534)2.67976793
190response to laminar fluid shear stress (GO:0034616)2.67407936
191response to monoamine (GO:0071867)2.63864948
192response to catecholamine (GO:0071869)2.63864948
193cGMP-mediated signaling (GO:0019934)2.63797906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.38453709
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.16843111
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.03276781
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.52443633
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.30639589
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.15363750
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.75631141
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.09753359
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06473828
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.58504757
11SALL1_21062744_ChIP-ChIP_HESCs_Human3.13230295
12E2F7_22180533_ChIP-Seq_HELA_Human2.54456701
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.29512635
14FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.18422968
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07821347
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02308758
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9978307
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94724240
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89807774
20PKCTHETA_26484144_Chip-Seq_BREAST_Human1.71278092
21AHR_22903824_ChIP-Seq_MCF-7_Human1.70097610
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.64663680
23GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.58842711
24HTT_18923047_ChIP-ChIP_STHdh_Human1.57731508
25ETV1_20927104_ChIP-Seq_GIST48_Human1.56112642
26GATA6_21074721_ChIP-Seq_CACO-2_Human1.54847057
27CLOCK_20551151_ChIP-Seq_293T_Human1.54361505
28FUS_26573619_Chip-Seq_HEK293_Human1.54016573
29HNFA_21074721_ChIP-Seq_CACO-2_Human1.51726299
30NFYB_21822215_ChIP-Seq_K562_Human1.49383017
31RBPJ_21746931_ChIP-Seq_IB4_Human1.47708724
32PHF8_20622853_ChIP-Seq_HELA_Human1.47547084
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.46882621
34CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.45587349
35GATA1_22025678_ChIP-Seq_K562_Human1.43922891
36HNF4A_19822575_ChIP-Seq_HepG2_Human1.41819291
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40893705
38NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36063709
39SCL_19346495_ChIP-Seq_HPC-7_Human1.34400914
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.31965518
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30691698
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27044972
43ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26002573
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24381384
45CBX2_22325352_ChIP-Seq_293T-Rex_Human1.22266757
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20692657
47RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19041821
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.18583295
49TP53_18474530_ChIP-ChIP_U2OS_Human1.18581088
50* EWS_26573619_Chip-Seq_HEK293_Human1.17780746
51KDM5A_27292631_Chip-Seq_BREAST_Human1.16798986
52TBL1_22424771_ChIP-Seq_293T_Human1.16584481
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15213039
54PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.14536242
55NFYA_21822215_ChIP-Seq_K562_Human1.13972491
56* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13929917
57SMC4_20622854_ChIP-Seq_HELA_Human1.10818284
58MAF_26560356_Chip-Seq_TH1_Human1.10021292
59DCP1A_22483619_ChIP-Seq_HELA_Human1.06475688
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.06307275
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04980385
62SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04980385
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03341836
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02842019
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02625687
66TFEB_21752829_ChIP-Seq_HELA_Human1.01812999
67CIITA_25753668_ChIP-Seq_RAJI_Human1.01785036
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99771180
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99382504
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98551766
71CHD1_26751641_Chip-Seq_LNCaP_Human0.97291889
72MAF_26560356_Chip-Seq_TH2_Human0.95354167
73UTX_26944678_Chip-Seq_JUKART_Human0.94766257
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94659954
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94487826
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94032105
77MYB_26560356_Chip-Seq_TH1_Human0.92262160
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91720461
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91704713
80SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91652689
81DROSHA_22980978_ChIP-Seq_HELA_Human0.91414468
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87902084
83IRF8_22096565_ChIP-ChIP_GC-B_Human0.86138830
84XRN2_22483619_ChIP-Seq_HELA_Human0.85804093
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85759815
86RUNX_20019798_ChIP-Seq_JUKART_Human0.85672720
87TCF7_22412390_ChIP-Seq_EML_Mouse0.85643508
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84567036
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84228445
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82853218
91TCF4_18268006_ChIP-ChIP_LS174T_Human0.81924255
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80273816
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80228339
94GATA4_25053715_ChIP-Seq_YYC3_Human0.79986048
95RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79580354
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.79373665
97* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78368399
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75715757
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75566934
100KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75326729
101RACK7_27058665_Chip-Seq_MCF-7_Human0.75073733
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74987282
103MYB_26560356_Chip-Seq_TH2_Human0.74435030
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74222114
105CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73789270
106UBF1/2_26484160_Chip-Seq_HMECs_Human0.73547607
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72744743
108ZNF263_19887448_ChIP-Seq_K562_Human0.72677002
109RARA_24833708_ChIP-Seq_LIVER_Mouse0.72583721
110CREB1_26743006_Chip-Seq_LNCaP_Human0.71447097
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71430394
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.71078088
113CTCF_21964334_ChIP-Seq_BJAB-B_Human0.70383067
114* STAT3_23295773_ChIP-Seq_U87_Human0.70007037
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69494620
116VDR_21846776_ChIP-Seq_THP-1_Human0.69318373
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.69135916
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68994448
119ESR2_21235772_ChIP-Seq_MCF-7_Human0.66725667
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65797929
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65797929
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64885986
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.61508001
124* RARB_24833708_ChIP-Seq_LIVER_Mouse0.59347993
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58543052
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57369172
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57043375
128CEBPB_22108803_ChIP-Seq_LS180_Human0.56887941
129* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56651420
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.54089525
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52597844
132EGR1_19032775_ChIP-ChIP_M12_Human0.51984350
133TAF15_26573619_Chip-Seq_HEK293_Human0.51536526
134LXR_22292898_ChIP-Seq_THP-1_Human0.51013047
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50452020
136MYC_19915707_ChIP-ChIP_AK7_Human0.50248553
137AR_20517297_ChIP-Seq_VCAP_Human0.50078342
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49644882
139FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.48760521
140STAT1_17558387_ChIP-Seq_HELA_Human0.48655824
141* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48471347
142E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.48271464
143* ESET_19884257_ChIP-Seq_ESCs_Mouse0.45926808
144PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45663085
145* CBP_21632823_ChIP-Seq_H3396_Human0.45638587
146P53_21459846_ChIP-Seq_SAOS-2_Human0.45580858
147ESR1_21235772_ChIP-Seq_MCF-7_Human0.45484526
148CDX2_20551321_ChIP-Seq_CACO-2_Human0.45290485
149GATA1_19941826_ChIP-Seq_K562_Human0.44980977
150PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44449420
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.43020908
152FOXO3_23340844_ChIP-Seq_DLD1_Human0.42680381
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41856632
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41633726
155PPAR_26484153_Chip-Seq_NCI-H1993_Human0.41401417
156GATA1_19941827_ChIP-Seq_MEL_Mouse0.41390204
157GATA2_19941826_ChIP-Seq_K562_Human0.41263703
158TAF2_19829295_ChIP-Seq_ESCs_Human0.40858018
159PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40770607
160BCAT_22108803_ChIP-Seq_LS180_Human0.40598120
161GATA6_25053715_ChIP-Seq_YYC3_Human0.38933858
162SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38605807
163ERG_21242973_ChIP-ChIP_JURKAT_Human0.38396388
164STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37819411
165MYC_27129775_Chip-Seq_CORNEA_Mouse0.37134061
166GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.36473335
167SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36421192
168LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35463557
169BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.34572962
170CDX2_22108803_ChIP-Seq_LS180_Human0.34204254
171IRF1_19129219_ChIP-ChIP_H3396_Human0.33958344
172FOXH1_21741376_ChIP-Seq_EPCs_Human0.33554089
173SPI1_26923725_Chip-Seq_HPCs_Mouse0.33392204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.37730321
2MP0005360_urolithiasis7.72264474
3* MP0005085_abnormal_gallbladder_physiolo6.26585348
4MP0005365_abnormal_bile_salt6.20495261
5MP0008875_abnormal_xenobiotic_pharmacok5.19085310
6MP0008057_abnormal_DNA_replication4.72791636
7MP0003806_abnormal_nucleotide_metabolis4.30108512
8MP0003252_abnormal_bile_duct3.96395822
9MP0002009_preneoplasia3.96377623
10MP0000569_abnormal_digit_pigmentation3.84594542
11MP0010329_abnormal_lipoprotein_level3.65690636
12MP0009840_abnormal_foam_cell3.28892035
13MP0000003_abnormal_adipose_tissue3.18633318
14MP0003195_calcinosis2.91051835
15MP0005332_abnormal_amino_acid2.77860290
16MP0001666_abnormal_nutrient_absorption2.61331373
17MP0005174_abnormal_tail_pigmentation2.57286891
18MP0004808_abnormal_hematopoietic_stem2.50587760
19MP0003191_abnormal_cellular_cholesterol2.39014673
20MP0005076_abnormal_cell_differentiation2.38490675
21MP0008058_abnormal_DNA_repair2.27083695
22* MP0000609_abnormal_liver_physiology2.18140498
23MP0004019_abnormal_vitamin_homeostasis2.16353429
24MP0003077_abnormal_cell_cycle2.13651236
25MP0002118_abnormal_lipid_homeostasis2.13000859
26MP0000013_abnormal_adipose_tissue2.07100873
27MP0002138_abnormal_hepatobiliary_system1.99444260
28MP0010094_abnormal_chromosome_stability1.94046823
29* MP0005083_abnormal_biliary_tract1.93466543
30MP0003868_abnormal_feces_composition1.93216219
31MP0003763_abnormal_thymus_physiology1.87875232
32MP0003693_abnormal_embryo_hatching1.79151252
33* MP0005319_abnormal_enzyme/_coenzyme1.78048945
34MP0008961_abnormal_basal_metabolism1.70788896
35MP0001986_abnormal_taste_sensitivity1.67294106
36MP0001764_abnormal_homeostasis1.66136375
37MP0005171_absent_coat_pigmentation1.64458491
38MP0009697_abnormal_copulation1.62183757
39MP0002396_abnormal_hematopoietic_system1.58598765
40MP0005253_abnormal_eye_physiology1.55939051
41* MP0005584_abnormal_enzyme/coenzyme_acti1.49878598
42MP0002160_abnormal_reproductive_system1.46892783
43MP0004133_heterotaxia1.46468180
44MP0003136_yellow_coat_color1.46429777
45MP0005623_abnormal_meninges_morphology1.43585808
46MP0004957_abnormal_blastocyst_morpholog1.43563365
47MP0002088_abnormal_embryonic_growth/wei1.42163668
48MP0003011_delayed_dark_adaptation1.41688857
49MP0005451_abnormal_body_composition1.40918676
50MP0005551_abnormal_eye_electrophysiolog1.40537530
51MP0003984_embryonic_growth_retardation1.39759470
52MP0003786_premature_aging1.37356083
53MP0004233_abnormal_muscle_weight1.35931263
54MP0002166_altered_tumor_susceptibility1.28915385
55MP0003656_abnormal_erythrocyte_physiolo1.28723040
56MP0003186_abnormal_redox_activity1.24753262
57MP0009643_abnormal_urine_homeostasis1.23341037
58MP0005423_abnormal_somatic_nervous1.22928461
59MP0004043_abnormal_pH_regulation1.20545265
60MP0000383_abnormal_hair_follicle1.19857930
61MP0003705_abnormal_hypodermis_morpholog1.19345630
62* MP0000598_abnormal_liver_morphology1.18479200
63MP0005375_adipose_tissue_phenotype1.16123043
64MP0005647_abnormal_sex_gland1.15664174
65MP0000604_amyloidosis1.14322250
66MP0000015_abnormal_ear_pigmentation1.13649346
67MP0002254_reproductive_system_inflammat1.12298419
68MP0005380_embryogenesis_phenotype1.09206741
69MP0001672_abnormal_embryogenesis/_devel1.09206741
70MP0009764_decreased_sensitivity_to1.08978499
71MP0002086_abnormal_extraembryonic_tissu1.08381589
72MP0006138_congestive_heart_failure1.04302663
73MP0010368_abnormal_lymphatic_system1.03186237
74* MP0009763_increased_sensitivity_to1.01563309
75MP0003937_abnormal_limbs/digits/tail_de1.00368650
76MP0010678_abnormal_skin_adnexa1.00120035
77MP0003699_abnormal_female_reproductive0.98409244
78MP0001929_abnormal_gametogenesis0.98072519
79MP0005391_vision/eye_phenotype0.97935476
80MP0009703_decreased_birth_body0.97512965
81MP0010307_abnormal_tumor_latency0.95801696
82MP0003111_abnormal_nucleus_morphology0.95427571
83MP0005636_abnormal_mineral_homeostasis0.93377899
84MP0002006_tumorigenesis0.93062131
85MP0002697_abnormal_eye_size0.91817012
86MP0001348_abnormal_lacrimal_gland0.91001627
87MP0002019_abnormal_tumor_incidence0.88124700
88* MP0008469_abnormal_protein_level0.88077918
89* MP0009642_abnormal_blood_homeostasis0.87662646
90MP0003303_peritoneal_inflammation0.86229441
91MP0005408_hypopigmentation0.86044697
92MP0005670_abnormal_white_adipose0.83160077
93MP0009765_abnormal_xenobiotic_induced0.81182188
94MP0002111_abnormal_tail_morphology0.81006637
95MP0005376_homeostasis/metabolism_phenot0.79971187
96MP0006036_abnormal_mitochondrial_physio0.79754049
97MP0004147_increased_porphyrin_level0.79657239
98MP0002078_abnormal_glucose_homeostasis0.79028088
99MP0005084_abnormal_gallbladder_morpholo0.78168349
100MP0001661_extended_life_span0.77970590
101MP0002332_abnormal_exercise_endurance0.76062678
102MP0002876_abnormal_thyroid_physiology0.75235557
103MP0002971_abnormal_brown_adipose0.75000311
104MP0003091_abnormal_cell_migration0.73672402
105MP0001346_abnormal_lacrimal_gland0.73009147
106MP0004130_abnormal_muscle_cell0.72364188
107MP0009278_abnormal_bone_marrow0.71678107
108MP0003690_abnormal_glial_cell0.71628129
109MP0002638_abnormal_pupillary_reflex0.71095390
110MP0005334_abnormal_fat_pad0.70647392
111MP0003950_abnormal_plasma_membrane0.70494979
112MP0005410_abnormal_fertilization0.69599005
113MP0006072_abnormal_retinal_apoptosis0.69298356
114MP0009053_abnormal_anal_canal0.68378664
115MP0004197_abnormal_fetal_growth/weight/0.67873112
116MP0003943_abnormal_hepatobiliary_system0.67227373
117MP0003329_amyloid_beta_deposits0.64716750
118MP0005266_abnormal_metabolism0.63948612
119MP0000639_abnormal_adrenal_gland0.62535314
120MP0001340_abnormal_eyelid_morphology0.62072657
121MP0000358_abnormal_cell_content/0.61789484
122MP0005464_abnormal_platelet_physiology0.60065458
123MP0001756_abnormal_urination0.58870236
124MP0005448_abnormal_energy_balance0.57665437
125MP0006035_abnormal_mitochondrial_morpho0.57643571
126* MP0005535_abnormal_body_temperature0.55908765
127MP0005395_other_phenotype0.51895892
128MP0002822_catalepsy0.48735270
129MP0003436_decreased_susceptibility_to0.48552217
130MP0002928_abnormal_bile_duct0.47962065
131* MP0005220_abnormal_exocrine_pancreas0.47312688
132MP0003638_abnormal_response/metabolism_0.47212509
133MP0003724_increased_susceptibility_to0.46870956
134MP0003718_maternal_effect0.46788732
135MP0008874_decreased_physiological_sensi0.46159548
136MP0002136_abnormal_kidney_physiology0.46096089
137MP0008873_increased_physiological_sensi0.45070674
138MP0004782_abnormal_surfactant_physiolog0.43220955
139MP0005248_abnormal_Harderian_gland0.42169729
140MP0003075_altered_response_to0.41838412
141MP0003953_abnormal_hormone_level0.41267929
142MP0002837_dystrophic_cardiac_calcinosis0.39486590
143MP0005166_decreased_susceptibility_to0.38783288
144MP0000579_abnormal_nail_morphology0.38142802
145MP0005666_abnormal_adipose_tissue0.37887299
146MP0009672_abnormal_birth_weight0.37490938
147MP0008872_abnormal_physiological_respon0.36312477
148MP0004381_abnormal_hair_follicle0.35247324
149MP0000249_abnormal_blood_vessel0.34109613
150MP0009384_cardiac_valve_regurgitation0.34108842
151MP0002168_other_aberrant_phenotype0.33738411
152MP0004883_abnormal_blood_vessel0.33437546
153MP0009115_abnormal_fat_cell0.33418740
154MP0001853_heart_inflammation0.32870671
155MP0006082_CNS_inflammation0.32437383
156MP0001243_abnormal_dermal_layer0.32427520
157MP0000230_abnormal_systemic_arterial0.31265883
158MP0002970_abnormal_white_adipose0.31196895
159MP0002796_impaired_skin_barrier0.30950054
160MP0001881_abnormal_mammary_gland0.28762547
161MP0005164_abnormal_response_to0.26731006
162* MP0001845_abnormal_inflammatory_respons0.26364829
163MP0002132_abnormal_respiratory_system0.24813544
164MP0002060_abnormal_skin_morphology0.24459153
165MP0000427_abnormal_hair_cycle0.24210176

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.56877622
2Intrahepatic cholestasis (HP:0001406)7.34484429
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.30119678
4Prolonged partial thromboplastin time (HP:0003645)6.74508410
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.63461872
6Hypobetalipoproteinemia (HP:0003563)6.47882568
7Fair hair (HP:0002286)6.30567231
8Xanthomatosis (HP:0000991)6.29641877
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.18728534
10Absent/shortened dynein arms (HP:0200106)5.96566732
11Dynein arm defect of respiratory motile cilia (HP:0012255)5.96566732
12Abnormal respiratory motile cilium morphology (HP:0005938)5.85230449
13Abnormal respiratory epithelium morphology (HP:0012253)5.85230449
14Abnormal ciliary motility (HP:0012262)5.64633589
15Abnormal respiratory motile cilium physiology (HP:0012261)5.63385927
16Complement deficiency (HP:0004431)5.56046941
17Hyperlipoproteinemia (HP:0010980)5.53164449
18Abnormality of the nasal septum (HP:0000419)5.33125350
19Cerebellar dysplasia (HP:0007033)5.29166766
20Rhinitis (HP:0012384)5.10527531
21Joint hemorrhage (HP:0005261)4.92753691
22Mild short stature (HP:0003502)4.86273222
23Hypolipoproteinemia (HP:0010981)4.84763557
24Abnormality of the common coagulation pathway (HP:0010990)4.71321179
25Epidermoid cyst (HP:0200040)4.59775977
26Hyperammonemia (HP:0001987)4.56902389
27Generalized hypopigmentation of hair (HP:0011358)4.47020973
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.43681563
29Hyperglycinemia (HP:0002154)4.41541583
30Abnormality of methionine metabolism (HP:0010901)4.25738658
31Abnormality of sulfur amino acid metabolism (HP:0004339)4.22254736
32Hypoalphalipoproteinemia (HP:0003233)4.21291922
33Ketosis (HP:0001946)4.19948144
34Fat malabsorption (HP:0002630)4.15689854
35Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12854881
36Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10781347
37Abnormality of complement system (HP:0005339)4.05877140
38Blue irides (HP:0000635)3.94228689
39Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.93739170
40Chronic bronchitis (HP:0004469)3.90064226
41Bronchiectasis (HP:0002110)3.89520743
42Increased circulating renin level (HP:0000848)3.89261448
43Abnormality of glycine metabolism (HP:0010895)3.87771309
44Abnormality of serine family amino acid metabolism (HP:0010894)3.87771309
45Hyperglycinuria (HP:0003108)3.85635474
46Hypokalemic alkalosis (HP:0001949)3.84270987
47Conjugated hyperbilirubinemia (HP:0002908)3.84189219
48Abnormality of the intrinsic pathway (HP:0010989)3.83245719
49Abnormality of the phalanges of the 2nd finger (HP:0009541)3.81204715
50Hypoglycemic coma (HP:0001325)3.80235368
51Abnormality of pyrimidine metabolism (HP:0004353)3.79145865
52Hypercholesterolemia (HP:0003124)3.71920737
53Retinal atrophy (HP:0001105)3.70932192
54Lip pit (HP:0100267)3.41540510
55Hyperbilirubinemia (HP:0002904)3.35571962
56Spontaneous abortion (HP:0005268)3.34060822
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26392708
58Abnormality of fatty-acid metabolism (HP:0004359)3.23058548
59Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.14294477
60Nasal polyposis (HP:0100582)3.13875949
61Delayed CNS myelination (HP:0002188)3.10161310
62Steatorrhea (HP:0002570)3.06193769
63Abnormality of serum amino acid levels (HP:0003112)3.03247785
64Abnormality of nucleobase metabolism (HP:0010932)3.02734562
65Myocardial infarction (HP:0001658)3.01114679
66Hypochromic microcytic anemia (HP:0004840)3.00810521
67Hepatocellular carcinoma (HP:0001402)3.00074286
68Ketoacidosis (HP:0001993)2.96118780
69Abnormal drinking behavior (HP:0030082)2.90274061
70Polydipsia (HP:0001959)2.90274061
71Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.90028445
72Aplasia of the musculature (HP:0100854)2.85331787
73Skin nodule (HP:0200036)2.85247825
74Abnormality of the middle phalanges of the toes (HP:0010183)2.83005121
75Systemic lupus erythematosus (HP:0002725)2.80229794
76Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.74624400
77Acanthocytosis (HP:0001927)2.74288886
78Metabolic acidosis (HP:0001942)2.69804826
79Glomerulonephritis (HP:0000099)2.69405691
80Abnormality of purine metabolism (HP:0004352)2.64528910
81Chronic hepatic failure (HP:0100626)2.60191329
82Vascular calcification (HP:0004934)2.60183832
83Poikiloderma (HP:0001029)2.59751975
84Elbow flexion contracture (HP:0002987)2.59595127
85Lethargy (HP:0001254)2.54933126
86Depressed nasal tip (HP:0000437)2.54339562
87Thickened helices (HP:0000391)2.53223447
88Dicarboxylic aciduria (HP:0003215)2.48800017
89Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48800017
90Abnormal gallbladder morphology (HP:0012437)2.47891547
91Hypoglycemic seizures (HP:0002173)2.47634119
92Abnormality of the periventricular white matter (HP:0002518)2.47485693
93Infertility (HP:0000789)2.46124838
94Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.46009935
95Spastic diplegia (HP:0001264)2.44876242
96Mitral stenosis (HP:0001718)2.43480261
97Abnormality of the epiphyses of the hand (HP:0005924)2.41769052
98Gout (HP:0001997)2.41251754
99Cholelithiasis (HP:0001081)2.41233619
100Gingival bleeding (HP:0000225)2.38726918
101Abnormality of renin-angiotensin system (HP:0000847)2.37942459
102Tetany (HP:0001281)2.37803563
103Amyloidosis (HP:0011034)2.36984299
104Recurrent gram-negative bacterial infections (HP:0005420)2.36713776
105Cholecystitis (HP:0001082)2.36521202
106Abnormal gallbladder physiology (HP:0012438)2.36521202
107Abnormality of the nasal mucosa (HP:0000433)2.36511766
108Cerebral edema (HP:0002181)2.35795720
109Bronchitis (HP:0012387)2.35426753
110Irritability (HP:0000737)2.32460527
111Cardiovascular calcification (HP:0011915)2.30732684
112Neonatal onset (HP:0003623)2.28877011
113Esophageal varix (HP:0002040)2.27985829
114Spinal canal stenosis (HP:0003416)2.27947285
115Amblyopia (HP:0000646)2.25988424
116Male infertility (HP:0003251)2.25537613
117Abnormality of the 2nd finger (HP:0004100)2.25348250
118Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.23549720
119Malnutrition (HP:0004395)2.23330515
120Dyschromatopsia (HP:0007641)2.22346824
121Menorrhagia (HP:0000132)2.22111129
122Thrombophlebitis (HP:0004418)2.19616751
123Abnormality of the ischium (HP:0003174)2.18660083
124Abnormality of the phalanges of the 5th finger (HP:0004213)2.16884480
125Fetal akinesia sequence (HP:0001989)2.14524770
126Poikilocytosis (HP:0004447)2.11595718
127Birth length less than 3rd percentile (HP:0003561)2.11559596
128Popliteal pterygium (HP:0009756)2.10829815
1292-3 toe syndactyly (HP:0004691)2.10752598
130Pancreatitis (HP:0001733)2.10612475
131Abnormality of DNA repair (HP:0003254)2.10468565
132Sensorimotor neuropathy (HP:0007141)2.10279587
133Enlarged kidneys (HP:0000105)2.09026873
134Late onset (HP:0003584)2.08394623
135Brushfield spots (HP:0001088)2.05865555
136Hemorrhage of the eye (HP:0011885)2.02603649
137Abnormality of the pons (HP:0007361)2.01477393
138Vomiting (HP:0002013)2.01381316
139Hyperinsulinemic hypoglycemia (HP:0000825)2.00479978
140Abnormality of the gallbladder (HP:0005264)2.00173387
141Opisthotonus (HP:0002179)1.98624482
142Polyuria (HP:0000103)1.97986130
143Generalized aminoaciduria (HP:0002909)1.97438716
144Recurrent sinusitis (HP:0011108)1.97327096
145Submucous cleft hard palate (HP:0000176)1.92028108
146Rickets (HP:0002748)1.91322453
147Abnormality of iron homeostasis (HP:0011031)1.88905123
148Nephritis (HP:0000123)1.88479639
149Ragged-red muscle fibers (HP:0003200)1.88445265
150Progressive muscle weakness (HP:0003323)1.88226687
151Abnormality of transition element cation homeostasis (HP:0011030)1.86969179
152Hypophosphatemic rickets (HP:0004912)1.85469187
153Median cleft lip (HP:0000161)1.85201587
154Hypomagnesemia (HP:0002917)1.84546371
155Abnormality of the labia majora (HP:0012881)1.84022692
156Abnormal cartilage morphology (HP:0002763)1.82776234
157Oculomotor apraxia (HP:0000657)1.81957694
158Abnormal enzyme/coenzyme activity (HP:0012379)1.80703938
159Hydroxyprolinuria (HP:0003080)1.80697137
160Abnormality of proline metabolism (HP:0010907)1.80697137
161Renal cortical cysts (HP:0000803)1.80615154
162Microvesicular hepatic steatosis (HP:0001414)1.80481874
163Elevated hepatic transaminases (HP:0002910)1.80119522
164Alkalosis (HP:0001948)1.79957641
165Short chin (HP:0000331)1.78436779
166Status epilepticus (HP:0002133)1.78108890
167Hypoplasia of the pons (HP:0012110)1.77725617
168Accelerated skeletal maturation (HP:0005616)1.76397678
169Prominent nose (HP:0000448)1.75516733
170Paralysis (HP:0003470)1.74675734
171Hyperglycemia (HP:0003074)1.73866802
172Entropion (HP:0000621)1.73278591
173White forelock (HP:0002211)1.72796615
174Homocystinuria (HP:0002156)1.71524241
175Abnormality of homocysteine metabolism (HP:0010919)1.71524241
176Stroke (HP:0001297)1.71424203
177Pulmonary embolism (HP:0002204)1.70969469
178Sparse lateral eyebrow (HP:0005338)1.66141990
179Aplasia/Hypoplasia involving the musculature (HP:0001460)1.65803295
180Wide intermamillary distance (HP:0006610)1.64413954
181Abnormal urine output (HP:0012590)1.63823704
182Chronic sinusitis (HP:0011109)1.63503461
183Aplasia cutis congenita (HP:0001057)1.63442034
184Calcaneovalgus deformity (HP:0001848)1.63132166
185Premature graying of hair (HP:0002216)1.62395032
186Knee flexion contracture (HP:0006380)1.60660037
187Recurrent otitis media (HP:0000403)1.60136299
188Ulnar bowing (HP:0003031)1.60055136
189Round face (HP:0000311)1.58797575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.93800161
2WNK45.43381366
3STK394.92458559
4FGFR44.71373811
5SIK14.65488448
6ERN14.42645610
7OXSR13.71415262
8NEK63.34319400
9TAOK33.20752508
10INSRR3.11076713
11ACVR1B2.98561782
12ERBB42.96835850
13MAP2K42.35482379
14AKT32.33765944
15BRD42.30487363
16PKN22.21597805
17MST1R2.17895201
18PDK210.3577796
19MAPK111.91464973
20PIK3CG1.89151177
21FLT31.88893392
22BMPR1B1.83595930
23TYK21.76384620
24TRIB31.75509776
25LATS11.71439228
26DAPK21.56509358
27PTK61.49992538
28BRSK21.45735751
29ABL21.44599277
30FGFR21.43845728
31FRK1.42442609
32NEK91.39756861
33KDR1.36912086
34RAF11.27395957
35JAK21.26523868
36CAMKK21.24671602
37MAP3K71.23227746
38TLK11.18115104
39BMPR21.17862794
40PIM21.15928291
41PRKAA21.13723534
42JAK11.10287933
43PIM11.10098246
44ERBB21.08409082
45PINK11.08261166
46STK111.06603613
47CDK121.05146889
48GRK61.03027918
49MAP2K31.01514772
50TBK11.01094986
51MAPK41.00486498
52MAP3K100.99446564
53MAP3K140.97049701
54ZAK0.96192755
55EPHB10.94262419
56RPS6KB20.93280959
57PRKCZ0.91338590
58EPHA30.90381217
59MET0.88636945
60MELK0.87528931
61STK38L0.82714724
62TGFBR10.81005069
63CDK60.80450779
64MAPK120.79759171
65CAMK1D0.79513699
66MAP3K30.79389366
67TIE10.76899730
68PRKACG0.76643590
69MAPK150.74132583
70CSK0.71624875
71DYRK1B0.69662901
72MAP3K110.69326526
73CAMK2G0.68154465
74PRKAA10.67921747
75GSK3A0.67364820
76SGK30.65400945
77RIPK10.65135736
78FGFR30.64905349
79ERBB30.63945169
80MAP2K60.60518732
81CSF1R0.60274315
82MAPK70.59377556
83TGFBR20.58942276
84IRAK30.55398453
85BLK0.53599032
86PTK20.53470523
87IKBKE0.52102008
88EPHA40.50382523
89PRKCQ0.49914486
90SGK20.48942374
91PDPK10.48001031
92CDK80.46671033
93CSNK1G10.46005096
94GRK10.45142103
95RET0.44720686
96IGF1R0.44497643
97MAP3K50.43973484
98PKN10.42111987
99ATR0.42052264
100MAP3K130.41263615
101PRKCG0.40054977
102MAP2K10.39524892
103TAOK20.39449565
104CDK40.39443246
105YES10.38912627
106MAP3K20.38039543
107ICK0.37971815
108MTOR0.37184071
109WNK10.35544252
110MAP3K60.35330879
111EGFR0.34642409
112SGK2230.33657529
113SGK4940.33657529
114MAP2K20.32601393
115TRPM70.32437658
116CAMK1G0.32005959
117TEC0.31911200
118TXK0.31868909
119MST40.31810532
120SGK10.31567758
121CAMK40.31423659
122SMG10.30772460
123SRPK10.30582676
124NUAK10.30529826
125IRAK10.29964178
126PDK10.29845906
127MAPK10.29776807
128CHEK20.29583617
129JAK30.29046660
130RPS6KA50.28558859
131PTK2B0.28212310
132MAPK100.27857805
133CHEK10.27413305
134MAP3K10.27296852
135PBK0.27159130
136MAPK80.26335698
137LATS20.26214270
138FES0.25584835
139PRKCA0.24902649
140MKNK20.24767954
141CDK20.24648105
142CSNK1G20.23762738
143IRAK20.23260297
144ADRBK10.22669785
145EEF2K0.22625388
146ABL10.22316325
147MAPK30.22218030
148GSK3B0.22182801
149PAK30.21912532
150NLK0.21267885
151PIK3CA0.20592511
152PDGFRB0.20380536
153BMX0.19538113
154CSNK1G30.19083369
155MAPK140.18858660
156PRKACB0.18138433
157AKT10.17645033
158RPS6KB10.17588244
159BTK0.17055879
160AURKB0.16689731
161PRKACA0.16525634
162CAMKK10.15774816
163ATM0.15553899
164STK380.15224052
165PLK10.14319591
166CDK10.14034069
167MARK20.13618626
168ITK0.13136531

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.48615540
2Nitrogen metabolism_Homo sapiens_hsa009103.79819038
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39617414
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36735907
5Arginine biosynthesis_Homo sapiens_hsa002203.07925637
6Complement and coagulation cascades_Homo sapiens_hsa046102.88320482
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71964574
8Tryptophan metabolism_Homo sapiens_hsa003802.65566390
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62035056
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53427025
11Fatty acid degradation_Homo sapiens_hsa000712.47316495
12TGF-beta signaling pathway_Homo sapiens_hsa043502.37729487
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35512297
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25508975
15Butanoate metabolism_Homo sapiens_hsa006502.15004230
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10666859
17Peroxisome_Homo sapiens_hsa041462.04246332
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.92267412
19Chemical carcinogenesis_Homo sapiens_hsa052041.92210892
20Propanoate metabolism_Homo sapiens_hsa006401.91233101
21Histidine metabolism_Homo sapiens_hsa003401.90035798
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88995762
23Staphylococcus aureus infection_Homo sapiens_hsa051501.88413709
24PPAR signaling pathway_Homo sapiens_hsa033201.85136543
25Fatty acid metabolism_Homo sapiens_hsa012121.80639995
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.77753535
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75505095
28beta-Alanine metabolism_Homo sapiens_hsa004101.70861216
29Retinol metabolism_Homo sapiens_hsa008301.68946663
30Caffeine metabolism_Homo sapiens_hsa002321.68744840
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66758200
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65464716
33Fanconi anemia pathway_Homo sapiens_hsa034601.61860979
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60198437
35Selenocompound metabolism_Homo sapiens_hsa004501.58809778
36Phenylalanine metabolism_Homo sapiens_hsa003601.55007207
37FoxO signaling pathway_Homo sapiens_hsa040681.51197743
38Bile secretion_Homo sapiens_hsa049761.51133804
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49632184
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48463929
41Tyrosine metabolism_Homo sapiens_hsa003501.42545504
42Morphine addiction_Homo sapiens_hsa050321.42051718
43Non-homologous end-joining_Homo sapiens_hsa034501.35809860
44Pyruvate metabolism_Homo sapiens_hsa006201.33864977
45Sulfur metabolism_Homo sapiens_hsa009201.30533572
46Fatty acid elongation_Homo sapiens_hsa000621.30074920
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.29884331
48Starch and sucrose metabolism_Homo sapiens_hsa005001.28843313
49Circadian rhythm_Homo sapiens_hsa047101.25811966
50Hedgehog signaling pathway_Homo sapiens_hsa043401.25448018
51ABC transporters_Homo sapiens_hsa020101.24973232
52Steroid biosynthesis_Homo sapiens_hsa001001.23386758
53Biosynthesis of amino acids_Homo sapiens_hsa012301.19693192
54Fat digestion and absorption_Homo sapiens_hsa049751.16748301
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16224912
56Folate biosynthesis_Homo sapiens_hsa007901.16129911
57Carbon metabolism_Homo sapiens_hsa012001.11473257
58Purine metabolism_Homo sapiens_hsa002301.04081394
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02738886
60Small cell lung cancer_Homo sapiens_hsa052221.01593908
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.01002578
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99271137
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98330292
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.97431841
65Vitamin B6 metabolism_Homo sapiens_hsa007500.94182844
66Arginine and proline metabolism_Homo sapiens_hsa003300.93943614
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.91789659
68Taste transduction_Homo sapiens_hsa047420.91240985
69Sulfur relay system_Homo sapiens_hsa041220.89206924
70Vitamin digestion and absorption_Homo sapiens_hsa049770.88102579
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85922980
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85646496
73mTOR signaling pathway_Homo sapiens_hsa041500.82310473
74Lysine degradation_Homo sapiens_hsa003100.81482329
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77590696
76One carbon pool by folate_Homo sapiens_hsa006700.77300645
77Basal cell carcinoma_Homo sapiens_hsa052170.73080606
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71167045
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69053255
80Glycerolipid metabolism_Homo sapiens_hsa005610.67085721
81Homologous recombination_Homo sapiens_hsa034400.64335200
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63594646
83Dorso-ventral axis formation_Homo sapiens_hsa043200.60848349
84Glutathione metabolism_Homo sapiens_hsa004800.60752077
85Cell cycle_Homo sapiens_hsa041100.60288488
86RNA transport_Homo sapiens_hsa030130.59387429
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57446347
88Pentose phosphate pathway_Homo sapiens_hsa000300.56723491
89Fatty acid biosynthesis_Homo sapiens_hsa000610.55021740
90Sphingolipid metabolism_Homo sapiens_hsa006000.53129868
91cAMP signaling pathway_Homo sapiens_hsa040240.49048401
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47892254
93Mismatch repair_Homo sapiens_hsa034300.47485176
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46133586
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45613162
96Metabolic pathways_Homo sapiens_hsa011000.44688835
97Hematopoietic cell lineage_Homo sapiens_hsa046400.43326669
98mRNA surveillance pathway_Homo sapiens_hsa030150.41881285
99p53 signaling pathway_Homo sapiens_hsa041150.41591409
100Hippo signaling pathway_Homo sapiens_hsa043900.41409151
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39487787
102Pancreatic cancer_Homo sapiens_hsa052120.39391193
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38650531
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37152239
105Prion diseases_Homo sapiens_hsa050200.35493514
106Toxoplasmosis_Homo sapiens_hsa051450.33183131
107DNA replication_Homo sapiens_hsa030300.29372468
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29020627
109Renin secretion_Homo sapiens_hsa049240.28987102
110MicroRNAs in cancer_Homo sapiens_hsa052060.27837587
111Adherens junction_Homo sapiens_hsa045200.27429524
112Inositol phosphate metabolism_Homo sapiens_hsa005620.27414621
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25436405
114Insulin resistance_Homo sapiens_hsa049310.24822455
115Spliceosome_Homo sapiens_hsa030400.24209281
116Galactose metabolism_Homo sapiens_hsa000520.24113739
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.23843696
118Nucleotide excision repair_Homo sapiens_hsa034200.23687726
119Fructose and mannose metabolism_Homo sapiens_hsa000510.21983418
120TNF signaling pathway_Homo sapiens_hsa046680.20816611
121Primary immunodeficiency_Homo sapiens_hsa053400.20549508
122Linoleic acid metabolism_Homo sapiens_hsa005910.20485894
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20231033
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.15243322
125Glucagon signaling pathway_Homo sapiens_hsa049220.10842112
126AMPK signaling pathway_Homo sapiens_hsa041520.02778755
127Amoebiasis_Homo sapiens_hsa05146-0.2383267
128Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2348779
129Pertussis_Homo sapiens_hsa05133-0.2347861
130Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2265581
131Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2186636
132Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1937766
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1902782
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1873632
135Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1815319
136Renin-angiotensin system_Homo sapiens_hsa04614-0.1801620
137Hepatitis C_Homo sapiens_hsa05160-0.1674198
138Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1557199
139Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1540263
140Regulation of autophagy_Homo sapiens_hsa04140-0.1451043
141African trypanosomiasis_Homo sapiens_hsa05143-0.1442950
142Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1173819
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0948319
144Insulin signaling pathway_Homo sapiens_hsa04910-0.0943413
145Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0687007
146Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0659729
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0659011

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