QPCT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.73319114
2regulation of type B pancreatic cell apoptotic process (GO:2000674)5.39264179
3endocrine pancreas development (GO:0031018)4.90186767
4epithelial cell fate commitment (GO:0072148)4.54935575
5inositol phosphate catabolic process (GO:0071545)4.49813712
6inositol phosphate dephosphorylation (GO:0046855)4.43103063
7phosphorylated carbohydrate dephosphorylation (GO:0046838)4.43103063
8insulin secretion (GO:0030073)4.31373271
9signal peptide processing (GO:0006465)4.18275714
10melanin biosynthetic process (GO:0042438)4.16102535
11peptide hormone processing (GO:0016486)4.14989460
12ketone body metabolic process (GO:1902224)4.09059531
13neurotransmitter-gated ion channel clustering (GO:0072578)3.98051032
14regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.95973928
15cellular ketone body metabolic process (GO:0046950)3.86351723
16positive regulation of glycolytic process (GO:0045821)3.83112141
17gonadal mesoderm development (GO:0007506)3.80244463
18negative regulation of execution phase of apoptosis (GO:1900118)3.78322194
19positive regulation of insulin secretion (GO:0032024)3.75150538
20vocalization behavior (GO:0071625)3.72350421
21lactate metabolic process (GO:0006089)3.71633243
22L-alpha-amino acid transmembrane transport (GO:1902475)3.71508182
23phagosome maturation (GO:0090382)3.71236762
24melanin metabolic process (GO:0006582)3.66290991
25regulation of penile erection (GO:0060405)3.65077623
26startle response (GO:0001964)3.58611229
27nitric oxide mediated signal transduction (GO:0007263)3.57255039
28positive regulation of macroautophagy (GO:0016239)3.53411145
29presynaptic membrane assembly (GO:0097105)3.51109264
30polyol catabolic process (GO:0046174)3.47958394
31positive regulation of gluconeogenesis (GO:0045722)3.45575986
32positive regulation of response to nutrient levels (GO:0032109)3.43830523
33positive regulation of response to extracellular stimulus (GO:0032106)3.43830523
34positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.42948123
35negative regulation of neurological system process (GO:0031645)3.41343552
36macroautophagy (GO:0016236)3.41183884
37transferrin transport (GO:0033572)3.40656201
38glandular epithelial cell differentiation (GO:0002067)3.34495772
39secondary metabolite biosynthetic process (GO:0044550)3.34276395
40regulation of autophagic vacuole assembly (GO:2000785)3.33122824
41positive regulation of peptide hormone secretion (GO:0090277)3.31632074
42positive regulation of cellular amide metabolic process (GO:0034250)3.30827829
43energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.27501537
44ATP hydrolysis coupled proton transport (GO:0015991)3.27501537
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25689677
46trivalent inorganic cation transport (GO:0072512)3.21886715
47ferric iron transport (GO:0015682)3.21886715
48protein localization to synapse (GO:0035418)3.19625006
49xenobiotic catabolic process (GO:0042178)3.17042525
50endosome to melanosome transport (GO:0035646)3.15660641
51endosome to pigment granule transport (GO:0043485)3.15660641
52positive regulation of peptide secretion (GO:0002793)3.15489468
53synaptic vesicle exocytosis (GO:0016079)3.13692578
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12636268
55oligosaccharide catabolic process (GO:0009313)3.11435729
56presynaptic membrane organization (GO:0097090)3.10231366
57postsynaptic membrane organization (GO:0001941)3.09925170
58type B pancreatic cell development (GO:0003323)3.09455215
59negative regulation of protein oligomerization (GO:0032460)3.07328512
60production of molecular mediator involved in inflammatory response (GO:0002532)3.06836435
61detection of calcium ion (GO:0005513)3.06809896
62negative regulation of glycoprotein biosynthetic process (GO:0010561)3.05906706
63nitric oxide biosynthetic process (GO:0006809)3.05810082
64negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04369528
65regulation of glucokinase activity (GO:0033131)3.03892768
66regulation of hexokinase activity (GO:1903299)3.03892768
67glucosamine-containing compound catabolic process (GO:1901072)3.01538181
68regulation of vacuole organization (GO:0044088)3.00186048
69retinal rod cell development (GO:0046548)2.99439990
70pigment cell differentiation (GO:0050931)2.99362551
71gamma-aminobutyric acid signaling pathway (GO:0007214)2.99195031
72sphingomyelin metabolic process (GO:0006684)2.94843063
73mating behavior (GO:0007617)2.94287529
74peptide hormone secretion (GO:0030072)2.93725429
75sequestering of metal ion (GO:0051238)2.92657472
76regulation of insulin secretion (GO:0050796)2.91477426
77developmental pigmentation (GO:0048066)2.90717645
78negative regulation of cAMP-mediated signaling (GO:0043951)2.87830382
79regulation of transmission of nerve impulse (GO:0051969)2.87190529
80negative regulation of acute inflammatory response (GO:0002674)2.86791313
81positive regulation of calcium ion import (GO:0090280)2.85443338
82peptide secretion (GO:0002790)2.84961629
83negative regulation of complement activation (GO:0045916)2.83566193
84regulation of synaptic vesicle exocytosis (GO:2000300)2.79824605
85neuromuscular process controlling posture (GO:0050884)2.79780527
86cerebellar granule cell differentiation (GO:0021707)2.79326546
87response to histamine (GO:0034776)2.78060544
88negative regulation of hormone biosynthetic process (GO:0032353)2.78037914
89auditory receptor cell differentiation (GO:0042491)2.77191002
90regulation of B cell apoptotic process (GO:0002902)2.76920734
91long-term synaptic potentiation (GO:0060291)2.76735808
92regulation of extracellular matrix disassembly (GO:0010715)2.74432760
93positive regulation of synapse assembly (GO:0051965)2.74404130
94regulation of fever generation (GO:0031620)2.73510798
95regulation of axon regeneration (GO:0048679)2.72678157
96regulation of neuron projection regeneration (GO:0070570)2.72678157
97regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.71817940
98negative regulation of mast cell activation (GO:0033004)2.70759014
99phospholipid dephosphorylation (GO:0046839)2.70297157
100regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70172237
101water-soluble vitamin biosynthetic process (GO:0042364)2.70115842
102detection of light stimulus involved in sensory perception (GO:0050962)2.70110728
103detection of light stimulus involved in visual perception (GO:0050908)2.70110728
104microglial cell activation (GO:0001774)2.67771519
105positive regulation of heat generation (GO:0031652)2.66351890
106regulation of energy homeostasis (GO:2000505)2.65470350
107regulation of beta-amyloid formation (GO:1902003)2.64844310
108regulation of peptide hormone secretion (GO:0090276)2.64098952
109positive regulation of protein autophosphorylation (GO:0031954)2.63924686
110respiratory chain complex IV assembly (GO:0008535)2.63138800
111astrocyte differentiation (GO:0048708)2.61990241
112glandular epithelial cell development (GO:0002068)2.60498688
113fatty acid homeostasis (GO:0055089)2.59033951
114regulation of synaptic transmission, glutamatergic (GO:0051966)2.58893513
115positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.58092526
116positive regulation by symbiont of host defense response (GO:0052509)2.57627964
117modulation by symbiont of host defense response (GO:0052031)2.57627964
118modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.57627964
119modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.57627964
120positive regulation by organism of defense response of other organism involved in symbiotic interact2.57627964
121modulation by symbiont of host immune response (GO:0052553)2.57627964
122regulation of peptide secretion (GO:0002791)2.57007848
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56069243
124intra-Golgi vesicle-mediated transport (GO:0006891)2.55272275
125neurotransmitter secretion (GO:0007269)2.55224503
126regulation of glutamate secretion (GO:0014048)2.55133602
127negative regulation of gluconeogenesis (GO:0045721)2.53083647
128cytochrome complex assembly (GO:0017004)2.52140830
129negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.51907134
130fatty acid elongation (GO:0030497)2.51558193
131positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.51171347
132melanocyte differentiation (GO:0030318)2.51021456
133peptide transport (GO:0015833)2.50433702
134positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.49788243
135positive regulation of autophagy (GO:0010508)2.49710991
136macrophage activation (GO:0042116)2.48878474
137locomotory exploration behavior (GO:0035641)2.48183545
138righting reflex (GO:0060013)2.47185977
139negative regulation of amino acid transport (GO:0051956)2.47144431
140regulation of memory T cell differentiation (GO:0043380)2.47008475
141long-chain fatty acid biosynthetic process (GO:0042759)2.46614790
142phosphatidylinositol dephosphorylation (GO:0046856)2.46595535
143nodal signaling pathway (GO:0038092)2.46528124
144regulation of glutamate receptor signaling pathway (GO:1900449)2.45671818
145response to glucose (GO:0009749)2.45301251
146proline transport (GO:0015824)2.45206212
147positive regulation of hormone secretion (GO:0046887)2.45177902
148regulation of voltage-gated calcium channel activity (GO:1901385)2.44946401
149zinc ion homeostasis (GO:0055069)2.44568619
150negative regulation of neurotransmitter transport (GO:0051589)2.43706933
151iron ion transport (GO:0006826)2.42244175
152regulation of feeding behavior (GO:0060259)2.41050846
153intracellular pH reduction (GO:0051452)2.40867877
154positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.40862514
155negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.39788778
156pH reduction (GO:0045851)2.39017888
157regulation of heat generation (GO:0031650)2.36803859
158eosinophil chemotaxis (GO:0048245)2.35393648
159gamma-aminobutyric acid transport (GO:0015812)2.34696595
160regulation of amyloid precursor protein catabolic process (GO:1902991)2.33459871
161synapse assembly (GO:0007416)2.32249257
162neutrophil activation involved in immune response (GO:0002283)2.31905520
163innervation (GO:0060384)2.30601995
164neurotransmitter biosynthetic process (GO:0042136)2.30517332
165neurotransmitter transport (GO:0006836)2.29717331
166detection of molecule of bacterial origin (GO:0032490)2.29016791
167membrane hyperpolarization (GO:0060081)2.28193015
168aldehyde catabolic process (GO:0046185)2.28146430
169opsonization (GO:0008228)2.26848447
170striatum development (GO:0021756)2.25881546
171regulation of synaptic vesicle transport (GO:1902803)2.25223776
172neuron recognition (GO:0008038)2.24917843
173neuron-neuron synaptic transmission (GO:0007270)2.23840181
174positive regulation of macrophage cytokine production (GO:0060907)2.21623519
175glycosphingolipid catabolic process (GO:0046479)2.21540723
176negative regulation of neurotransmitter secretion (GO:0046929)2.20224319
177exploration behavior (GO:0035640)2.19969418
178glycerophospholipid catabolic process (GO:0046475)2.19316265
179dopamine biosynthetic process (GO:0042416)2.18219631
180adult walking behavior (GO:0007628)2.17638919
181cellular potassium ion homeostasis (GO:0030007)2.17346650
182response to auditory stimulus (GO:0010996)2.16710364
183membrane assembly (GO:0071709)2.14790515
184peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.14230094
185negative regulation of amine transport (GO:0051953)2.13182336
186regulation of cellular amide metabolic process (GO:0034248)2.13173226
187antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.12380599
188cofactor catabolic process (GO:0051187)2.12020480
189regulation of dopamine metabolic process (GO:0042053)2.11405584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.94266132
2GBX2_23144817_ChIP-Seq_PC3_Human3.87107902
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.98525533
4TAF15_26573619_Chip-Seq_HEK293_Human2.84561350
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61527829
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.41821071
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40992550
8AR_21572438_ChIP-Seq_LNCaP_Human2.38886914
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.37435318
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32855505
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15894580
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12947028
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.12601061
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08465589
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04046749
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00822705
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.97400382
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92215270
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91221419
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89111077
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87653906
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86986683
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86097590
24ER_23166858_ChIP-Seq_MCF-7_Human1.81596763
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80111022
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.75052846
27P300_19829295_ChIP-Seq_ESCs_Human1.74997638
28EZH2_22144423_ChIP-Seq_EOC_Human1.74132001
29TFEB_21752829_ChIP-Seq_HELA_Human1.73946154
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.72501479
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.72166312
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.71396223
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70772452
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.70099285
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69815573
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69657090
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69657090
38SMAD4_21799915_ChIP-Seq_A2780_Human1.67236918
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.65362422
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61017664
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57097952
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.56596537
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54854783
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.52222359
45REST_21632747_ChIP-Seq_MESCs_Mouse1.52221851
46IGF1R_20145208_ChIP-Seq_DFB_Human1.51439920
47* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51431381
48* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51431381
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47861830
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47332151
51FUS_26573619_Chip-Seq_HEK293_Human1.42129783
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.42019303
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39833964
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38696444
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.38426330
56AR_25329375_ChIP-Seq_VCAP_Human1.37808305
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37396963
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.36556143
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36479236
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36372766
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36000352
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33704654
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.33170319
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.32529892
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32491364
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32042274
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30301009
68FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.28841823
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28192311
70HTT_18923047_ChIP-ChIP_STHdh_Human1.26758386
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24941737
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24425331
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.23696438
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23266204
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22684165
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20318760
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20229886
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.19988900
79FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19909921
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.19909921
81ZNF274_21170338_ChIP-Seq_K562_Hela1.19113445
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19103256
83CDX2_22108803_ChIP-Seq_LS180_Human1.18904454
84DROSHA_22980978_ChIP-Seq_HELA_Human1.16722063
85P53_22387025_ChIP-Seq_ESCs_Mouse1.16693923
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15997900
87* JUN_21703547_ChIP-Seq_K562_Human1.14666989
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14478610
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.14015192
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.13969608
91* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13953654
92* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13225315
93VDR_22108803_ChIP-Seq_LS180_Human1.12815257
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12364515
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12298624
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11304323
97TP53_22573176_ChIP-Seq_HFKS_Human1.11100000
98CTCF_18555785_Chip-Seq_ESCs_Mouse1.09823361
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09639465
100IRF8_22096565_ChIP-ChIP_GC-B_Human1.08936207
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08564045
102LXR_22158963_ChIP-Seq_LIVER_Mouse1.08295923
103* KDM2B_26808549_Chip-Seq_REH_Human1.06927307
104SOX2_18555785_Chip-Seq_ESCs_Mouse1.06838058
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.06672079
106TP53_18474530_ChIP-ChIP_U2OS_Human1.06268072
107* STAT3_23295773_ChIP-Seq_U87_Human1.06066153
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05767686
109NMYC_18555785_Chip-Seq_ESCs_Mouse1.05535629
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05139913
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04172923
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04116865
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04028468
114RNF2_27304074_Chip-Seq_NSC_Mouse1.03845715
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.03389456
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.03193208
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02748376
118CBP_20019798_ChIP-Seq_JUKART_Human1.02748376
119* FOXA1_25552417_ChIP-Seq_VCAP_Human1.02611531
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02245119
121* SOX2_20726797_ChIP-Seq_SW620_Human1.01661872
122* PRDM14_20953172_ChIP-Seq_ESCs_Human1.01350627
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01278998
124BCAT_22108803_ChIP-Seq_LS180_Human1.00960495
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00470352
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.00011952
127GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99775663
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98284621
129ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98243846
130NANOG_19829295_ChIP-Seq_ESCs_Human0.98081381
131SOX2_19829295_ChIP-Seq_ESCs_Human0.98081381
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97994821
133IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97922578
134AR_20517297_ChIP-Seq_VCAP_Human0.97741454
135RUNX2_22187159_ChIP-Seq_PCA_Human0.97616578
136P300_18555785_Chip-Seq_ESCs_Mouse0.97450067
137* GATA3_26560356_Chip-Seq_TH2_Human0.96384784
138OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96222072
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96192870
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96056258
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96041420
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95926790
143PU1_27457419_Chip-Seq_LIVER_Mouse0.94981187
144FLI1_21867929_ChIP-Seq_TH2_Mouse0.94418266
145CMYC_18555785_Chip-Seq_ESCs_Mouse0.94311374
146RXR_22158963_ChIP-Seq_LIVER_Mouse0.93975499
147EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93880277
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.93257688
149TCF4_23295773_ChIP-Seq_U87_Human0.93154659
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.92715371
151OCT4_18555785_Chip-Seq_ESCs_Mouse0.92056708
152* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91945218
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91481522
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90413679
155MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90331789
156ARNT_22903824_ChIP-Seq_MCF-7_Human0.90218768
157MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89742401
158SMRT_27268052_Chip-Seq_Bcells_Human0.88952349
159KLF4_18555785_Chip-Seq_ESCs_Mouse0.88692455
160FLI1_27457419_Chip-Seq_LIVER_Mouse0.88411890
161FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87044413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.28690110
2MP0002837_dystrophic_cardiac_calcinosis3.97091578
3MP0005379_endocrine/exocrine_gland_phen3.61289349
4MP0003880_abnormal_central_pattern3.55431902
5MP0002822_catalepsy3.37352773
6MP0000372_irregular_coat_pigmentation3.35263322
7MP0005075_abnormal_melanosome_morpholog3.25408060
8MP0002163_abnormal_gland_morphology2.99732760
9MP0003195_calcinosis2.80834200
10MP0002693_abnormal_pancreas_physiology2.80384681
11MP0000015_abnormal_ear_pigmentation2.79209699
12MP0003787_abnormal_imprinting2.58190039
13MP0001944_abnormal_pancreas_morphology2.51807763
14MP0002064_seizures2.44938514
15MP0009046_muscle_twitch2.34233308
16MP0005408_hypopigmentation2.31462513
17MP0005551_abnormal_eye_electrophysiolog2.29088995
18MP0005058_abnormal_lysosome_morphology2.26522068
19MP0000604_amyloidosis2.21432997
20MP0005423_abnormal_somatic_nervous2.18086468
21MP0003950_abnormal_plasma_membrane2.17342058
22MP0010386_abnormal_urinary_bladder2.12810119
23MP0002090_abnormal_vision2.11776710
24MP0006082_CNS_inflammation2.11553729
25MP0003635_abnormal_synaptic_transmissio2.10961836
26MP0005174_abnormal_tail_pigmentation2.08557585
27MP0009745_abnormal_behavioral_response2.07040868
28MP0000013_abnormal_adipose_tissue2.06716373
29MP0003283_abnormal_digestive_organ2.04805441
30MP0000920_abnormal_myelination2.03333238
31MP0003172_abnormal_lysosome_physiology2.02604142
32MP0001529_abnormal_vocalization2.02453231
33MP0003011_delayed_dark_adaptation1.99473056
34MP0005171_absent_coat_pigmentation1.98678986
35MP0003690_abnormal_glial_cell1.93622959
36MP0001968_abnormal_touch/_nociception1.93454956
37MP0001984_abnormal_olfaction1.93222950
38MP0004381_abnormal_hair_follicle1.87957028
39MP0002572_abnormal_emotion/affect_behav1.85497755
40MP0006276_abnormal_autonomic_nervous1.85114805
41MP0003183_abnormal_peptide_metabolism1.84810385
42MP0000569_abnormal_digit_pigmentation1.80880537
43MP0001440_abnormal_grooming_behavior1.79452020
44MP0002272_abnormal_nervous_system1.79068367
45MP0002063_abnormal_learning/memory/cond1.78877271
46MP0003329_amyloid_beta_deposits1.77367600
47MP0004142_abnormal_muscle_tone1.74247413
48MP0003122_maternal_imprinting1.73941906
49MP0002736_abnormal_nociception_after1.72524381
50MP0001486_abnormal_startle_reflex1.68650821
51MP0005220_abnormal_exocrine_pancreas1.65244433
52MP0002078_abnormal_glucose_homeostasis1.64521680
53MP0001905_abnormal_dopamine_level1.63709709
54MP0000371_diluted_coat_color1.60129542
55MP0003879_abnormal_hair_cell1.59973624
56MP0008438_abnormal_cutaneous_collagen1.59463557
57MP0002277_abnormal_respiratory_mucosa1.57593077
58MP0002254_reproductive_system_inflammat1.55169940
59MP0003634_abnormal_glial_cell1.52448307
60MP0003724_increased_susceptibility_to1.51940647
61MP0004742_abnormal_vestibular_system1.51605531
62MP0001501_abnormal_sleep_pattern1.49696403
63MP0005645_abnormal_hypothalamus_physiol1.47698601
64MP0010329_abnormal_lipoprotein_level1.47418552
65MP0002067_abnormal_sensory_capabilities1.46697745
66MP0004859_abnormal_synaptic_plasticity1.46368800
67MP0008877_abnormal_DNA_methylation1.45646491
68MP0002735_abnormal_chemical_nociception1.45573212
69MP0002734_abnormal_mechanical_nocicepti1.44150553
70MP0005164_abnormal_response_to1.43464245
71MP0001958_emphysema1.43049593
72MP0005253_abnormal_eye_physiology1.40501324
73MP0002095_abnormal_skin_pigmentation1.40483573
74MP0001756_abnormal_urination1.40151899
75MP0005646_abnormal_pituitary_gland1.36519359
76MP0009785_altered_susceptibility_to1.31041356
77MP0001502_abnormal_circadian_rhythm1.30977820
78MP0005248_abnormal_Harderian_gland1.26290633
79MP0004019_abnormal_vitamin_homeostasis1.25042923
80MP0000639_abnormal_adrenal_gland1.23273399
81MP0002928_abnormal_bile_duct1.22896323
82MP0004883_abnormal_blood_vessel1.20911092
83MP0001970_abnormal_pain_threshold1.19808317
84MP0005386_behavior/neurological_phenoty1.17166756
85MP0004924_abnormal_behavior1.17166756
86MP0002733_abnormal_thermal_nociception1.15694717
87MP0004858_abnormal_nervous_system1.14955698
88MP0002229_neurodegeneration1.13100670
89MP0003136_yellow_coat_color1.11757248
90MP0005084_abnormal_gallbladder_morpholo1.10208254
91MP0003123_paternal_imprinting1.07724801
92MP0002876_abnormal_thyroid_physiology1.06285984
93MP0005636_abnormal_mineral_homeostasis1.06221040
94MP0002148_abnormal_hypersensitivity_rea1.04281879
95MP0003632_abnormal_nervous_system1.04246024
96MP0003303_peritoneal_inflammation1.02609624
97MP0002638_abnormal_pupillary_reflex1.01495819
98MP0001765_abnormal_ion_homeostasis1.01438202
99MP0008260_abnormal_autophagy1.01379623
100MP0008875_abnormal_xenobiotic_pharmacok1.00915764
101MP0002139_abnormal_hepatobiliary_system1.00679532
102MP0005332_abnormal_amino_acid1.00094745
103MP0005448_abnormal_energy_balance0.99602559
104MP0003953_abnormal_hormone_level0.97395268
105MP0002419_abnormal_innate_immunity0.96563901
106MP0003075_altered_response_to0.96298072
107MP0002332_abnormal_exercise_endurance0.95697182
108MP0002118_abnormal_lipid_homeostasis0.94917721
109MP0001324_abnormal_eye_pigmentation0.94898906
110MP0006054_spinal_hemorrhage0.93799410
111MP0002184_abnormal_innervation0.93761810
112MP0000343_altered_response_to0.92350347
113MP0002075_abnormal_coat/hair_pigmentati0.92245893
114MP0001186_pigmentation_phenotype0.91444220
115MP0000003_abnormal_adipose_tissue0.90088964
116MP0001661_extended_life_span0.89205427
117MP0004270_analgesia0.89147712
118MP0002882_abnormal_neuron_morphology0.88843444
119MP0004043_abnormal_pH_regulation0.87875139
120MP0002166_altered_tumor_susceptibility0.87836317
121MP0005195_abnormal_posterior_eye0.87728857
122MP0002066_abnormal_motor_capabilities/c0.87097369
123MP0001542_abnormal_bone_strength0.86543081
124MP0003191_abnormal_cellular_cholesterol0.86100260
125MP0002938_white_spotting0.86083198
126MP0009764_decreased_sensitivity_to0.84934980
127MP0002557_abnormal_social/conspecific_i0.84715594
128MP0005365_abnormal_bile_salt0.84037886
129MP0000751_myopathy0.83683419
130MP0006072_abnormal_retinal_apoptosis0.81542615
131MP0002909_abnormal_adrenal_gland0.81412360
132MP0003045_fibrosis0.81268019
133MP0000685_abnormal_immune_system0.80552367
134MP0005595_abnormal_vascular_smooth0.80307748
135MP0005410_abnormal_fertilization0.79874212
136MP0003631_nervous_system_phenotype0.79790935
137MP0000427_abnormal_hair_cycle0.78931200
138MP0004885_abnormal_endolymph0.78779152
139MP0010678_abnormal_skin_adnexa0.78739725
140MP0003300_gastrointestinal_ulcer0.77218901
141MP0001963_abnormal_hearing_physiology0.75368769
142MP0009840_abnormal_foam_cell0.74899797
143MP0005367_renal/urinary_system_phenotyp0.74823828
144MP0000516_abnormal_urinary_system0.74823828
145MP0002168_other_aberrant_phenotype0.73938407
146MP0009697_abnormal_copulation0.73754900
147MP0003121_genomic_imprinting0.73114852
148MP0003633_abnormal_nervous_system0.73025704
149MP0009780_abnormal_chondrocyte_physiolo0.72755373
150MP0005310_abnormal_salivary_gland0.71877403
151MP0006036_abnormal_mitochondrial_physio0.69324831
152MP0009643_abnormal_urine_homeostasis0.68962414
153MP0005000_abnormal_immune_tolerance0.68813151
154MP0001835_abnormal_antigen_presentation0.68330811
155MP0003806_abnormal_nucleotide_metabolis0.67869117
156MP0005535_abnormal_body_temperature0.67830650
157MP0001188_hyperpigmentation0.67568638
158MP0001986_abnormal_taste_sensitivity0.67486786
159MP0008874_decreased_physiological_sensi0.67145737
160MP0001845_abnormal_inflammatory_respons0.66962698
161MP0002877_abnormal_melanocyte_morpholog0.66538173
162MP0001177_atelectasis0.66030331
163MP0008469_abnormal_protein_level0.63281562
164MP0001790_abnormal_immune_system0.62286118
165MP0005387_immune_system_phenotype0.62286118
166MP0002102_abnormal_ear_morphology0.62052281

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)5.07968296
2Hyperinsulinemic hypoglycemia (HP:0000825)4.98608735
3Hypoglycemic coma (HP:0001325)4.56640315
4Ketoacidosis (HP:0001993)4.53489077
5Increased neuronal autofluorescent lipopigment (HP:0002074)4.46665125
6Increased cerebral lipofuscin (HP:0011813)4.37785915
7Hyperglycemia (HP:0003074)4.23725327
8Focal motor seizures (HP:0011153)4.00506681
9Large for gestational age (HP:0001520)4.00039922
10Abnormality of the pancreatic islet cells (HP:0006476)3.99918590
11Abnormality of endocrine pancreas physiology (HP:0012093)3.99918590
12Aplasia/Hypoplasia of the fovea (HP:0008060)3.76194065
13Hypoplasia of the fovea (HP:0007750)3.76194065
14Symptomatic seizures (HP:0011145)3.52750887
15Congenital stationary night blindness (HP:0007642)3.47680743
16Enlarged penis (HP:0000040)3.43309616
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.42776050
18Hyperventilation (HP:0002883)3.33839880
19Atonic seizures (HP:0010819)3.32159233
20Late onset (HP:0003584)3.29343856
21Absence seizures (HP:0002121)3.28575558
22Aplasia/Hypoplasia of the macula (HP:0008059)3.27773923
23Increased CSF protein (HP:0002922)3.26790575
24Vacuolated lymphocytes (HP:0001922)3.23615268
25Progressive neurologic deterioration (HP:0002344)3.17952641
26Polyphagia (HP:0002591)3.17872468
27Hematochezia (HP:0002573)3.14484090
28Ketosis (HP:0001946)3.06040375
29Aplasia/Hypoplasia affecting the retina (HP:0008061)3.05370430
30Generalized tonic-clonic seizures (HP:0002069)3.03342589
31Neurofibrillary tangles (HP:0002185)3.03049340
32Conjunctival hamartoma (HP:0100780)3.02819391
33Ocular albinism (HP:0001107)3.00595888
34Progressive inability to walk (HP:0002505)2.95043248
35Limb dystonia (HP:0002451)2.94981959
36Abnormality of the fovea (HP:0000493)2.94460016
37Dialeptic seizures (HP:0011146)2.94431703
38Hypothermia (HP:0002045)2.92130094
39Albinism (HP:0001022)2.89711707
40Agitation (HP:0000713)2.89553277
41Neuroendocrine neoplasm (HP:0100634)2.88461048
42Double outlet right ventricle (HP:0001719)2.87379555
43Congenital malformation of the right heart (HP:0011723)2.87379555
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.85536862
45Insulin-resistant diabetes mellitus (HP:0000831)2.83299309
46Iris hypopigmentation (HP:0007730)2.79620437
47Congenital sensorineural hearing impairment (HP:0008527)2.78947364
48Recurrent gram-negative bacterial infections (HP:0005420)2.77189442
49Blue irides (HP:0000635)2.74645507
50Patchy hypopigmentation of hair (HP:0011365)2.74079645
51Myokymia (HP:0002411)2.69884019
52Clumsiness (HP:0002312)2.69237127
53Hypomagnesemia (HP:0002917)2.69132714
54Abnormality of glycolipid metabolism (HP:0010969)2.68161187
55Abnormality of liposaccharide metabolism (HP:0010968)2.68161187
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.68161187
57Intestinal atresia (HP:0011100)2.68134552
58Abnormal hair whorl (HP:0010721)2.64856242
59White forelock (HP:0002211)2.64267110
60Episodic fever (HP:0001954)2.64158762
61Dysostosis multiplex (HP:0000943)2.61822387
62Neoplasm of head and neck (HP:0012288)2.58654599
63Esophageal neoplasm (HP:0100751)2.58654599
64Testicular neoplasm (HP:0010788)2.58374834
65Focal seizures (HP:0007359)2.56941053
66Hamartoma of the eye (HP:0010568)2.55728645
67Increased corneal curvature (HP:0100692)2.55718708
68Keratoconus (HP:0000563)2.55718708
69Generalized hypopigmentation (HP:0007513)2.52376955
70Pancreatic islet-cell hyperplasia (HP:0004510)2.51853712
71Postural tremor (HP:0002174)2.48512225
72Abnormality of vitamin B metabolism (HP:0004340)2.48483397
73Pheochromocytoma (HP:0002666)2.44615096
74Nuclear cataract (HP:0100018)2.40381168
75Muscle fibrillation (HP:0010546)2.39827032
76Hyperthyroidism (HP:0000836)2.38752599
77Decreased central vision (HP:0007663)2.35031615
78Hemiparesis (HP:0001269)2.33358272
79Ankle clonus (HP:0011448)2.32006185
80Febrile seizures (HP:0002373)2.31893119
81Degeneration of the lateral corticospinal tracts (HP:0002314)2.30905149
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30905149
83Epileptic encephalopathy (HP:0200134)2.30879450
84Tongue fasciculations (HP:0001308)2.30721779
85Mutism (HP:0002300)2.28505172
86Abolished electroretinogram (ERG) (HP:0000550)2.27684668
87Cerebral inclusion bodies (HP:0100314)2.26155837
88Neuronal loss in central nervous system (HP:0002529)2.24876780
89Supranuclear gaze palsy (HP:0000605)2.21246308
90Poor suck (HP:0002033)2.21099270
91EEG with generalized epileptiform discharges (HP:0011198)2.20814509
92Neoplasm of the peripheral nervous system (HP:0100007)2.18868727
93Abnormality of calcium-phosphate metabolism (HP:0100530)2.18843185
94Medial flaring of the eyebrow (HP:0010747)2.18665299
95Systemic lupus erythematosus (HP:0002725)2.18444538
96Synostosis involving the elbow (HP:0003938)2.18376326
97Humeroradial synostosis (HP:0003041)2.18376326
98Loss of speech (HP:0002371)2.17676918
99Aqueductal stenosis (HP:0002410)2.15667184
100Acute necrotizing encephalopathy (HP:0006965)2.15405341
101Gait imbalance (HP:0002141)2.15277444
102Epileptiform EEG discharges (HP:0011182)2.13198263
103Abnormality of macular pigmentation (HP:0008002)2.10310997
104Prominent metopic ridge (HP:0005487)2.09889716
105Inability to walk (HP:0002540)2.09199819
106Failure to thrive in infancy (HP:0001531)2.08931675
107Hypsarrhythmia (HP:0002521)2.08575673
108Cutaneous melanoma (HP:0012056)2.08496848
109Generalized myoclonic seizures (HP:0002123)2.08477578
110Abnormality of binocular vision (HP:0011514)2.07912986
111Diplopia (HP:0000651)2.07912986
112Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07691085
113Methylmalonic acidemia (HP:0002912)2.06867241
114Diminished movement (HP:0002374)2.06835419
115Neoplasm of the adrenal cortex (HP:0100641)2.06789405
116Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06446748
117Abnormality of macrophages (HP:0004311)2.04325306
118Gonadal dysgenesis (HP:0000133)2.03808202
119Recurrent abscess formation (HP:0002722)2.03171597
120Eczematoid dermatitis (HP:0000976)2.02762710
121Abnormal mitochondria in muscle tissue (HP:0008316)2.02381313
122Vascular calcification (HP:0004934)2.02014827
123Congenital primary aphakia (HP:0007707)2.01576040
124Oligomenorrhea (HP:0000876)2.01203698
125Hyperphosphatemia (HP:0002905)2.00816997
126Recurrent bacterial skin infections (HP:0005406)1.98839157
127Heterochromia iridis (HP:0001100)1.98813624
128Abnormal pupillary function (HP:0007686)1.98335827
129Akinesia (HP:0002304)1.98150096
130Abnormality of vitamin metabolism (HP:0100508)1.97833786
131Stomatitis (HP:0010280)1.97501147
132Cardiomegaly (HP:0001640)1.97393172
133Abnormality of magnesium homeostasis (HP:0004921)1.96994619
134Hypokinesia (HP:0002375)1.96912539
135Sensory axonal neuropathy (HP:0003390)1.96699390
136Muscular hypotonia of the trunk (HP:0008936)1.96143745
137Hypoventilation (HP:0002791)1.95479631
138Myoclonus (HP:0001336)1.95067093
139Orthostatic hypotension (HP:0001278)1.94877761
140Mucopolysacchariduria (HP:0008155)1.93338366
141Urinary glycosaminoglycan excretion (HP:0003541)1.93338366
142Progressive cerebellar ataxia (HP:0002073)1.92225932
143Autoamputation (HP:0001218)1.90486790
144Increased IgM level (HP:0003496)1.90424137
145Visual hallucinations (HP:0002367)1.89712479
146Absent speech (HP:0001344)1.89343713
147Widely spaced teeth (HP:0000687)1.89027386
148Cholecystitis (HP:0001082)1.88468206
149Abnormal gallbladder physiology (HP:0012438)1.88468206
150Retinal atrophy (HP:0001105)1.88013332
151Abnormal albumin level (HP:0012116)1.87111913
152Hypoalbuminemia (HP:0003073)1.87111913
153Abnormal eating behavior (HP:0100738)1.86687344
154Macroorchidism (HP:0000053)1.86591973
155Truncal ataxia (HP:0002078)1.86180791
156Central scotoma (HP:0000603)1.85115525
157Petechiae (HP:0000967)1.84050189
158Progressive macrocephaly (HP:0004481)1.83516684
159Methylmalonic aciduria (HP:0012120)1.83052000
160Unilateral renal agenesis (HP:0000122)1.82727453
161Septo-optic dysplasia (HP:0100842)1.82319477
162Abnormality of polysaccharide metabolism (HP:0011012)1.82260903
163Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82260903
164Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82260903
165Anxiety (HP:0000739)1.81526900
166Specific learning disability (HP:0001328)1.79468175
167Nephrogenic diabetes insipidus (HP:0009806)1.79226954
168Abnormality of the corticospinal tract (HP:0002492)1.78969427
169Polydipsia (HP:0001959)1.77834502
170Abnormal drinking behavior (HP:0030082)1.77834502
171Abnormal pancreas size (HP:0012094)1.77380495
172Optic disc pallor (HP:0000543)1.77338114
173Parakeratosis (HP:0001036)1.76330528
174Increased circulating renin level (HP:0000848)1.75866870
175Abnormality of the metopic suture (HP:0005556)1.75249407
176Zonular cataract (HP:0010920)1.71229947
177Intention tremor (HP:0002080)1.69983164
178Cardiovascular calcification (HP:0011915)1.64835600
179Abnormal rod and cone electroretinograms (HP:0008323)1.63128639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.24699942
2CASK6.25189236
3FGFR23.82427005
4MAP3K123.27067236
5PBK2.64451182
6NTRK32.49832604
7FGFR32.45334142
8MAP3K42.32649807
9MAP3K22.29154079
10MAP2K62.16723545
11MAP2K72.15085646
12ERBB42.09721138
13MAP4K22.08749560
14NLK2.07908426
15PLK21.84432524
16ACVR1B1.78981047
17GRK71.76955537
18TAOK11.75893628
19LIMK11.67467543
20AKT31.59127752
21TRPM71.59114109
22IRAK21.58821476
23ADRBK21.55316546
24OXSR11.53974937
25MARK11.47208008
26MYLK1.46656236
27FER1.46142454
28YES11.44844318
29PKN11.39156656
30BCR1.36235170
31GRK51.36178268
32PRPF4B1.35117547
33NTRK21.33674589
34STK31.32468631
35PAK61.30863853
36MAP3K141.28460977
37STK391.27876211
38MAP3K31.26337601
39PASK1.23850013
40FGR1.18736570
41HIPK21.18384495
42MAP3K11.18219141
43ARAF1.16733623
44ERBB31.15768499
45MAPKAPK51.12828069
46TBK11.12299131
47MAP2K41.11512225
48CAMK2A1.10133006
49PHKG11.09752799
50PHKG21.09752799
51NTRK11.04477041
52SGK2231.04161586
53SGK4941.04161586
54FES1.02829078
55PRKCE1.01406887
56MINK10.97027659
57CSNK1G30.95620552
58STK240.95362468
59DAPK20.93725842
60PDK20.92815581
61BMPR1B0.89214171
62CDK50.87854140
63TXK0.86781166
64MAP2K30.85433533
65PRKCG0.85335402
66IRAK10.85310787
67BLK0.85038605
68PAK30.84252358
69CSNK1G20.84102897
70LMTK20.83916945
71STK40.82060468
72CAMK2G0.81927549
73TESK10.81868066
74EIF2AK30.81840153
75EPHA30.80645346
76MAP3K130.78371538
77TSSK60.77976030
78CAMK2D0.77539437
79PINK10.77186367
80CDK190.76589136
81PRKD20.76282923
82WNK30.76038174
83BMPR20.75256288
84STK110.75224361
85TNK20.74719066
86GRK60.74355395
87TYRO30.74166617
88IRAK40.72779459
89CSNK1A1L0.72630407
90GRK10.71639629
91ERN10.71501786
92IKBKE0.70410404
93PNCK0.70052809
94PRKAA20.69136845
95RIPK40.67974996
96ADRBK10.65338678
97SGK30.65142740
98PTK2B0.64729619
99PDK10.63750123
100CAMK2B0.63368411
101TYK20.62905680
102ITK0.62722305
103MAP3K90.62599267
104TNIK0.62174710
105INSRR0.61643921
106MOS0.61251653
107PRKCQ0.60627257
108DAPK30.58543326
109PRKCH0.58451526
110ROCK20.58126012
111PDGFRA0.57598535
112GSK3A0.57369524
113PRKG20.57153801
114CSK0.57011808
115IRAK30.56517129
116EPHB10.55290660
117DDR20.55057658
118TESK20.54965800
119CDK140.53605911
120STK380.52616579
121PDPK10.52518342
122TAOK30.52398743
123MST40.51992834
124FYN0.51573678
125CAMKK20.50613880
126CSNK1G10.50382148
127DAPK10.50321779
128SGK20.50200823
129ZAP700.49253709
130LYN0.49072896
131SIK30.48988237
132JAK10.48800821
133KIT0.48372460
134WNK40.48048623
135CDK30.47965738
136STK38L0.47732878
137IKBKB0.46986838
138RET0.45801014
139UHMK10.45777656
140HCK0.45496580
141MUSK0.45488652
142ROCK10.44902860
143IGF1R0.44530688
144LCK0.44528321
145MARK30.40464992
146MAPK70.36134199
147MAP4K10.36083333
148STK100.33124431
149PRKG10.31950002
150JAK20.31908929
151PRKCZ0.31725181
152EIF2AK10.30721124
153PRKAA10.30712814

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.23645387
2Collecting duct acid secretion_Homo sapiens_hsa049663.73588185
3Synaptic vesicle cycle_Homo sapiens_hsa047213.20822762
4Nicotine addiction_Homo sapiens_hsa050332.83335930
5Rheumatoid arthritis_Homo sapiens_hsa053232.57558284
6Vibrio cholerae infection_Homo sapiens_hsa051102.42174913
7GABAergic synapse_Homo sapiens_hsa047272.37727669
8Oxidative phosphorylation_Homo sapiens_hsa001902.34389432
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.33126078
10Folate biosynthesis_Homo sapiens_hsa007902.20501809
11Phagosome_Homo sapiens_hsa041452.15174389
12Lysosome_Homo sapiens_hsa041422.10351632
13Vitamin B6 metabolism_Homo sapiens_hsa007501.95040088
14Fatty acid elongation_Homo sapiens_hsa000621.93100387
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.88159218
16Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.87396630
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83691048
18Morphine addiction_Homo sapiens_hsa050321.82684013
19Regulation of autophagy_Homo sapiens_hsa041401.74169800
20Type II diabetes mellitus_Homo sapiens_hsa049301.70406226
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56434835
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45174971
23Staphylococcus aureus infection_Homo sapiens_hsa051501.43602089
24Parkinsons disease_Homo sapiens_hsa050121.43237682
25Type I diabetes mellitus_Homo sapiens_hsa049401.40955543
26Other glycan degradation_Homo sapiens_hsa005111.40201601
27Graft-versus-host disease_Homo sapiens_hsa053321.39318539
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34348704
29Circadian rhythm_Homo sapiens_hsa047101.31772223
30Complement and coagulation cascades_Homo sapiens_hsa046101.31418809
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30690203
32Serotonergic synapse_Homo sapiens_hsa047261.29673801
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24228279
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23281494
35Alzheimers disease_Homo sapiens_hsa050101.22544056
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20341050
37Phototransduction_Homo sapiens_hsa047441.13991406
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11898655
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05836058
40Steroid biosynthesis_Homo sapiens_hsa001001.03485498
41Glutamatergic synapse_Homo sapiens_hsa047241.02709787
42Circadian entrainment_Homo sapiens_hsa047131.00630728
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99533767
44N-Glycan biosynthesis_Homo sapiens_hsa005100.98941072
45Olfactory transduction_Homo sapiens_hsa047400.98762350
46Butanoate metabolism_Homo sapiens_hsa006500.97864102
47Histidine metabolism_Homo sapiens_hsa003400.96339617
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95470079
49Dopaminergic synapse_Homo sapiens_hsa047280.94269140
50Sphingolipid metabolism_Homo sapiens_hsa006000.94198713
51Selenocompound metabolism_Homo sapiens_hsa004500.93930369
52Dorso-ventral axis formation_Homo sapiens_hsa043200.93370489
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.92073421
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89508813
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88470652
56Malaria_Homo sapiens_hsa051440.87206342
57Prion diseases_Homo sapiens_hsa050200.85872694
58Renin secretion_Homo sapiens_hsa049240.84820273
59Glucagon signaling pathway_Homo sapiens_hsa049220.82965510
60Cocaine addiction_Homo sapiens_hsa050300.82831670
61Tryptophan metabolism_Homo sapiens_hsa003800.82357128
62Legionellosis_Homo sapiens_hsa051340.81603185
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79905589
64Cholinergic synapse_Homo sapiens_hsa047250.79390690
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.77979864
66Ether lipid metabolism_Homo sapiens_hsa005650.77609186
67Long-term depression_Homo sapiens_hsa047300.75278165
68Salivary secretion_Homo sapiens_hsa049700.74776720
69ABC transporters_Homo sapiens_hsa020100.74099880
70Inositol phosphate metabolism_Homo sapiens_hsa005620.74052610
71Taste transduction_Homo sapiens_hsa047420.71736222
72Cardiac muscle contraction_Homo sapiens_hsa042600.71430891
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71015954
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70506738
75Allograft rejection_Homo sapiens_hsa053300.70096286
76Amphetamine addiction_Homo sapiens_hsa050310.69697799
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68308082
78Osteoclast differentiation_Homo sapiens_hsa043800.66641170
79mTOR signaling pathway_Homo sapiens_hsa041500.65869809
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65767163
81Insulin resistance_Homo sapiens_hsa049310.62699765
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62421957
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62340843
84Huntingtons disease_Homo sapiens_hsa050160.61645585
85Calcium signaling pathway_Homo sapiens_hsa040200.61593151
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61458740
87Peroxisome_Homo sapiens_hsa041460.60719876
88Tuberculosis_Homo sapiens_hsa051520.59104163
89Fatty acid metabolism_Homo sapiens_hsa012120.57877737
90Phenylalanine metabolism_Homo sapiens_hsa003600.56829639
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.56037298
92Axon guidance_Homo sapiens_hsa043600.55538180
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.55318246
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54978447
95Arginine biosynthesis_Homo sapiens_hsa002200.54598113
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54270277
97Sulfur metabolism_Homo sapiens_hsa009200.53503736
98Pancreatic secretion_Homo sapiens_hsa049720.53071363
99Galactose metabolism_Homo sapiens_hsa000520.51816919
100Autoimmune thyroid disease_Homo sapiens_hsa053200.51610695
101Insulin secretion_Homo sapiens_hsa049110.50549451
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48316843
103Gap junction_Homo sapiens_hsa045400.47797113
104Glutathione metabolism_Homo sapiens_hsa004800.45850724
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.45769946
106Dilated cardiomyopathy_Homo sapiens_hsa054140.45086945
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44088810
108Salmonella infection_Homo sapiens_hsa051320.44003502
109Vitamin digestion and absorption_Homo sapiens_hsa049770.43670938
110Gastric acid secretion_Homo sapiens_hsa049710.43647046
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43319090
112African trypanosomiasis_Homo sapiens_hsa051430.43212106
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43034254
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.42948131
115Pyruvate metabolism_Homo sapiens_hsa006200.42705057
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42286820
117Asthma_Homo sapiens_hsa053100.40973440
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40396923
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40071395
120Ovarian steroidogenesis_Homo sapiens_hsa049130.39791165
121FoxO signaling pathway_Homo sapiens_hsa040680.39600012
122Oxytocin signaling pathway_Homo sapiens_hsa049210.39344368
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37601163
124Chemokine signaling pathway_Homo sapiens_hsa040620.36761796
125Protein export_Homo sapiens_hsa030600.36500080
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35719099
127Tyrosine metabolism_Homo sapiens_hsa003500.35669905
128Thyroid hormone synthesis_Homo sapiens_hsa049180.35457076
129ECM-receptor interaction_Homo sapiens_hsa045120.35357298
130Retinol metabolism_Homo sapiens_hsa008300.34505062
131Pertussis_Homo sapiens_hsa051330.33187909
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32937814
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32930247
134PPAR signaling pathway_Homo sapiens_hsa033200.32656209
135Arachidonic acid metabolism_Homo sapiens_hsa005900.32602923
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32506811
137Mineral absorption_Homo sapiens_hsa049780.32483419
138Metabolic pathways_Homo sapiens_hsa011000.32423324
139Leishmaniasis_Homo sapiens_hsa051400.31470888
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31137365
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30528392
142Starch and sucrose metabolism_Homo sapiens_hsa005000.30463635
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30118856
144beta-Alanine metabolism_Homo sapiens_hsa004100.30017624
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.28557240
146Insulin signaling pathway_Homo sapiens_hsa049100.27472301
147Prolactin signaling pathway_Homo sapiens_hsa049170.27401677
148Fatty acid degradation_Homo sapiens_hsa000710.27123419
149cAMP signaling pathway_Homo sapiens_hsa040240.26271198
150Propanoate metabolism_Homo sapiens_hsa006400.25162108
151GnRH signaling pathway_Homo sapiens_hsa049120.25029136

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