QRFPR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.31434247
2neurotransmitter catabolic process (GO:0042135)5.55275124
3neurotransmitter-gated ion channel clustering (GO:0072578)5.55090362
4regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.43205742
5regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)5.40971279
6neuron cell-cell adhesion (GO:0007158)5.13910604
7viral transcription (GO:0019083)5.08983853
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.08852312
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98051842
10regulation of glutamate receptor signaling pathway (GO:1900449)4.96817137
11synaptic vesicle exocytosis (GO:0016079)4.93738317
12translational termination (GO:0006415)4.89494774
13neuronal action potential propagation (GO:0019227)4.88814800
14maturation of SSU-rRNA (GO:0030490)4.85652083
15chaperone-mediated protein transport (GO:0072321)4.80814355
16vocalization behavior (GO:0071625)4.78387854
17neuron recognition (GO:0008038)4.67160487
18presynaptic membrane assembly (GO:0097105)4.61602597
19transcription from mitochondrial promoter (GO:0006390)4.61034309
20negative regulation of synaptic transmission, GABAergic (GO:0032229)4.59020568
21protein localization to synapse (GO:0035418)4.56372766
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.53275940
23glutamate secretion (GO:0014047)4.47810612
24cotranslational protein targeting to membrane (GO:0006613)4.46808780
25transcription elongation from RNA polymerase III promoter (GO:0006385)4.41935758
26termination of RNA polymerase III transcription (GO:0006386)4.41935758
27protein targeting to ER (GO:0045047)4.40106665
28DNA replication checkpoint (GO:0000076)4.38565805
29ribosomal large subunit biogenesis (GO:0042273)4.31855067
30gamma-aminobutyric acid signaling pathway (GO:0007214)4.29510809
31ribonucleoprotein complex biogenesis (GO:0022613)4.29058563
32regulation of mitotic spindle organization (GO:0060236)4.26044475
33translational elongation (GO:0006414)4.23513252
34establishment of protein localization to endoplasmic reticulum (GO:0072599)4.22526964
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.18162016
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.15085095
37protein localization to endoplasmic reticulum (GO:0070972)4.14275493
38energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.12530260
39ATP hydrolysis coupled proton transport (GO:0015991)4.12530260
40response to histamine (GO:0034776)4.12382625
41glutamate receptor signaling pathway (GO:0007215)4.12075120
42paraxial mesoderm development (GO:0048339)4.10011701
43presynaptic membrane organization (GO:0097090)4.07389580
44axonal fasciculation (GO:0007413)4.04501276
45translational initiation (GO:0006413)4.04113954
46pseudouridine synthesis (GO:0001522)4.02192901
47ionotropic glutamate receptor signaling pathway (GO:0035235)4.01394332
48ribosomal small subunit assembly (GO:0000028)3.97443354
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.97437627
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.96454739
51postsynaptic membrane organization (GO:0001941)3.92779010
52rRNA modification (GO:0000154)3.92541319
53establishment of apical/basal cell polarity (GO:0035089)3.88618868
54translation (GO:0006412)3.87206638
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83699409
56ATP synthesis coupled proton transport (GO:0015986)3.83699409
57startle response (GO:0001964)3.83303790
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.82903337
59cellular protein complex disassembly (GO:0043624)3.79610734
60protein targeting to mitochondrion (GO:0006626)3.79608941
61cellular component biogenesis (GO:0044085)3.76952608
62proteasome assembly (GO:0043248)3.74764187
63polarized epithelial cell differentiation (GO:0030859)3.74318833
64viral life cycle (GO:0019058)3.73979616
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.71201600
66formation of translation preinitiation complex (GO:0001731)3.67094204
67ribosome biogenesis (GO:0042254)3.66323825
68cellular response to zinc ion (GO:0071294)3.66110276
69cerebellar granule cell differentiation (GO:0021707)3.62657316
70locomotory exploration behavior (GO:0035641)3.62619680
71neurotransmitter secretion (GO:0007269)3.59278453
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.58690599
73DNA strand elongation involved in DNA replication (GO:0006271)3.57940529
74establishment of protein localization to mitochondrion (GO:0072655)3.57889181
75nucleobase-containing small molecule interconversion (GO:0015949)3.57369134
76negative regulation of dendrite morphogenesis (GO:0050774)3.53853263
77rRNA processing (GO:0006364)3.53474649
78regulation of spindle organization (GO:0090224)3.52526155
79positive regulation of synapse assembly (GO:0051965)3.50835292
80muscle organ morphogenesis (GO:0048644)3.50831047
81protein localization to mitochondrion (GO:0070585)3.49748385
82neuron-neuron synaptic transmission (GO:0007270)3.48782699
83oxygen transport (GO:0015671)3.47561600
84regulation of synaptic vesicle exocytosis (GO:2000300)3.47515733
85mitochondrial respiratory chain complex assembly (GO:0033108)3.45240993
86outer ear morphogenesis (GO:0042473)3.43444000
87DNA strand elongation (GO:0022616)3.42461483
88mechanosensory behavior (GO:0007638)3.42301926
89auditory behavior (GO:0031223)3.41624769
90transferrin transport (GO:0033572)3.38568231
91proline transport (GO:0015824)3.37868006
92rRNA metabolic process (GO:0016072)3.37665256
93telomere maintenance via semi-conservative replication (GO:0032201)3.37040249
94regulation of postsynaptic membrane potential (GO:0060078)3.35196010
95exploration behavior (GO:0035640)3.34762647
96synaptic vesicle endocytosis (GO:0048488)3.33408730
97synaptic transmission, glutamatergic (GO:0035249)3.33348799
98regulation of synaptic transmission, glutamatergic (GO:0051966)3.32730653
99regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32505443
100protein complex biogenesis (GO:0070271)3.30629669
101regulation of mitochondrial translation (GO:0070129)3.29686785
102membrane hyperpolarization (GO:0060081)3.27378386
103mitochondrial RNA metabolic process (GO:0000959)3.25519918
104establishment or maintenance of monopolar cell polarity (GO:0061339)3.24989199
105establishment of monopolar cell polarity (GO:0061162)3.24989199
106intracellular protein transmembrane import (GO:0044743)3.24599330
107spliceosomal snRNP assembly (GO:0000387)3.22918820
108protein complex disassembly (GO:0043241)3.22432125
109regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21230088
110macromolecular complex disassembly (GO:0032984)3.17410697
111membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16205635
112neurotransmitter transport (GO:0006836)3.13136260
113regulation of lipoprotein particle clearance (GO:0010984)3.12864185
114long-term synaptic potentiation (GO:0060291)3.11924665
115ferric iron transport (GO:0015682)3.10979408
116trivalent inorganic cation transport (GO:0072512)3.10979408
117mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10181198
118mitochondrial respiratory chain complex I assembly (GO:0032981)3.10181198
119NADH dehydrogenase complex assembly (GO:0010257)3.10181198
120synaptic vesicle docking involved in exocytosis (GO:0016081)3.09415299
121positive regulation of receptor biosynthetic process (GO:0010870)3.08329900
122nuclear-transcribed mRNA catabolic process (GO:0000956)3.07714458
123protein targeting to membrane (GO:0006612)3.06273470
124phagosome maturation (GO:0090382)3.05344285
125regulation of long-term neuronal synaptic plasticity (GO:0048169)3.04261754
126DNA damage response, detection of DNA damage (GO:0042769)3.02713675
127base-excision repair, AP site formation (GO:0006285)3.01593972
128synaptic vesicle maturation (GO:0016188)3.00999659
129establishment of protein localization to mitochondrial membrane (GO:0090151)3.00940721
130cochlea development (GO:0090102)3.00451701
131regulation of neurotransmitter levels (GO:0001505)2.99907165
132opioid receptor signaling pathway (GO:0038003)2.98503077
133pteridine-containing compound biosynthetic process (GO:0042559)2.97415185
134positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.94750959
135pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.93949038
136negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93721298
137mitotic metaphase plate congression (GO:0007080)2.93600310
138membrane depolarization (GO:0051899)2.93062400
139respiratory electron transport chain (GO:0022904)2.92633488
140substantia nigra development (GO:0021762)2.92552243
141regulation of synaptic vesicle transport (GO:1902803)2.92348063
142mRNA catabolic process (GO:0006402)2.91149086
143G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.89962596
144histone mRNA metabolic process (GO:0008334)2.89708661
145regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88921126
146regulation of synapse structural plasticity (GO:0051823)2.88651773
147synaptic transmission, cholinergic (GO:0007271)2.88230001
148heterochromatin organization (GO:0070828)2.87945583
149rRNA methylation (GO:0031167)2.87760433
150DNA replication initiation (GO:0006270)2.87204209
151CENP-A containing nucleosome assembly (GO:0034080)2.86962434
152pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.86949099
153chromatin remodeling at centromere (GO:0031055)2.86657606
154electron transport chain (GO:0022900)2.85094239
155renal absorption (GO:0070293)2.83642841
156IMP biosynthetic process (GO:0006188)2.83584858
157pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.82958765
158regulation of protein kinase A signaling (GO:0010738)2.82733451
159exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82062654
160regulation of synapse assembly (GO:0051963)2.81710326
161ribosome assembly (GO:0042255)2.79882467
162folic acid-containing compound biosynthetic process (GO:0009396)2.79470182
163response to auditory stimulus (GO:0010996)2.78666067
164mating behavior (GO:0007617)2.78626822
165cellular response to ammonium ion (GO:0071242)2.78275635
166regulation of synaptic plasticity (GO:0048167)2.78010787
167regulation of neuronal synaptic plasticity (GO:0048168)2.77941261
168telomere maintenance via recombination (GO:0000722)2.77029241
169synapse assembly (GO:0007416)2.76380316
170membrane depolarization during action potential (GO:0086010)2.76053275
171dendrite development (GO:0016358)2.75656392
172detection of mechanical stimulus involved in sensory perception (GO:0050974)2.75292388
173positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.74871308
174regulation of vesicle fusion (GO:0031338)2.74814346
175transmission of nerve impulse (GO:0019226)2.74058547
176negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72834495
177negative regulation of ligase activity (GO:0051352)2.72834495
178righting reflex (GO:0060013)2.72472531
179RNA catabolic process (GO:0006401)2.72106033
180positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70806620
181fear response (GO:0042596)2.70627248
182anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70280802
183behavioral defense response (GO:0002209)2.70085564
184behavioral fear response (GO:0001662)2.70085564
185layer formation in cerebral cortex (GO:0021819)2.69525502
186regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69460892
187pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.68032601
188nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67553883
189pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.67415404
190nucleobase biosynthetic process (GO:0046112)2.67261918
191protein transmembrane transport (GO:0071806)2.66803298
192cellular copper ion homeostasis (GO:0006878)2.65412863
193mitochondrial transport (GO:0006839)2.65066476

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.77763314
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.95045600
3E2F7_22180533_ChIP-Seq_HELA_Human4.71414605
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59008304
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.04962275
6GBX2_23144817_ChIP-Seq_PC3_Human4.04641644
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.74127334
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.57128775
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53926110
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.36920909
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.35399097
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.21753731
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19954446
14TAF15_26573619_Chip-Seq_HEK293_Human3.16990302
15MYC_18358816_ChIP-ChIP_MESCs_Mouse3.13839893
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07534653
17MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06122551
18E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02605533
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99132687
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.97685144
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95192601
22VDR_22108803_ChIP-Seq_LS180_Human2.78643656
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.75990512
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67663566
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66894003
26XRN2_22483619_ChIP-Seq_HELA_Human2.66161736
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58822190
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.55936415
29TTF2_22483619_ChIP-Seq_HELA_Human2.55210139
30AR_21909140_ChIP-Seq_LNCAP_Human2.51651354
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49330597
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47017190
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41622723
34RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40582069
35EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40582069
36* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39783704
37EZH2_27304074_Chip-Seq_ESCs_Mouse2.37091736
38CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35411741
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.31918451
40DCP1A_22483619_ChIP-Seq_HELA_Human2.31068600
41E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28656207
42THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27708579
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25599113
44* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24941131
45* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23922128
46ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21428869
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20718032
48MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16990687
49* REST_21632747_ChIP-Seq_MESCs_Mouse2.15099128
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14416277
51NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12382290
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06782500
53FUS_26573619_Chip-Seq_HEK293_Human2.06034174
54SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03870500
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03234121
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.98295669
57ELK1_19687146_ChIP-ChIP_HELA_Human1.94355944
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94181605
59AR_21572438_ChIP-Seq_LNCaP_Human1.92656136
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91733097
61VDR_23849224_ChIP-Seq_CD4+_Human1.88744299
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87937623
63P300_19829295_ChIP-Seq_ESCs_Human1.86911148
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.86812580
65DROSHA_22980978_ChIP-Seq_HELA_Human1.86021714
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.84364140
67SMAD4_21799915_ChIP-Seq_A2780_Human1.83891731
68GABP_19822575_ChIP-Seq_HepG2_Human1.83667281
69IGF1R_20145208_ChIP-Seq_DFB_Human1.81571456
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.81248272
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79530006
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75491687
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.73616812
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72864587
75FOXP3_21729870_ChIP-Seq_TREG_Human1.71865562
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71760465
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71316701
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69990061
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66608321
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65314379
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64967244
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.62347453
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.61429257
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60875779
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60512366
86ER_23166858_ChIP-Seq_MCF-7_Human1.57757763
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57436937
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.57262330
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56790997
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55857453
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52284889
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.51942358
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50742738
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50721793
95P53_22127205_ChIP-Seq_FIBROBLAST_Human1.50215662
96SRF_21415370_ChIP-Seq_HL-1_Mouse1.48752860
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.48701764
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48655240
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48368025
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47976024
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46320174
102RNF2_27304074_Chip-Seq_NSC_Mouse1.44167166
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44127035
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42874248
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42757304
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.38306202
107MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38154005
108ELK1_22589737_ChIP-Seq_MCF10A_Human1.37250756
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36970806
110ZNF274_21170338_ChIP-Seq_K562_Hela1.36859925
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36703874
112AR_25329375_ChIP-Seq_VCAP_Human1.36164479
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35161366
114BCAT_22108803_ChIP-Seq_LS180_Human1.34848496
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34646380
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34362750
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.32537833
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30244081
119KDM5A_27292631_Chip-Seq_BREAST_Human1.29806562
120SOX2_21211035_ChIP-Seq_LN229_Gbm1.29476514
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27268743
122NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26167588
123CBP_20019798_ChIP-Seq_JUKART_Human1.25751625
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25751625
125STAT3_23295773_ChIP-Seq_U87_Human1.24539554
126RUNX2_22187159_ChIP-Seq_PCA_Human1.23358663
127* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23233353
128* NANOG_18555785_Chip-Seq_ESCs_Mouse1.19089099
129ERG_21242973_ChIP-ChIP_JURKAT_Human1.17774373
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17107676
131NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16865632
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15980173
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15693171
134CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15605270
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14505883
136MYC_18940864_ChIP-ChIP_HL60_Human1.14009060
137ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13818656
138* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13001773
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12931374
140TP53_18474530_ChIP-ChIP_U2OS_Human1.12766833
141* TCF4_23295773_ChIP-Seq_U87_Human1.12752258
142NOTCH1_21737748_ChIP-Seq_TLL_Human1.12109750
143FLI1_27457419_Chip-Seq_LIVER_Mouse1.10943491
144HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10937691
145TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10375315
146CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09325844
147MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08779060
148FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08500346
149PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08343411
150PRDM14_20953172_ChIP-Seq_ESCs_Human1.07816719
151SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06712649
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06572825
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06572825
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06413039
155CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06225662
156KDM2B_26808549_Chip-Seq_REH_Human1.05934352
157JUN_21703547_ChIP-Seq_K562_Human1.05893760
158ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05404390
159KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03514368
160* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02425156
161TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02357673
162CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02251796
163ARNT_22903824_ChIP-Seq_MCF-7_Human1.02246954
164EWS_26573619_Chip-Seq_HEK293_Human1.00093075
165ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99547663
166TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98406909
167ZNF263_19887448_ChIP-Seq_K562_Human0.98111455
168SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97943026
169ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97517068
170PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97207042
171MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97170018
172TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96734261
173TP53_16413492_ChIP-PET_HCT116_Human0.96554668
174AHR_22903824_ChIP-Seq_MCF-7_Human0.96244366
175YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95831239
176HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92744563
177TP63_19390658_ChIP-ChIP_HaCaT_Human0.92582159
178CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90252341
179SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89809787
180CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89116624
181DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87691465
182CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86585162
183CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84908721
184NANOG_16153702_ChIP-ChIP_HESCs_Human0.83788519
185SOX17_20123909_ChIP-Seq_XEN_Mouse0.79472470
186KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77866591
187TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77623292
188SOX2_18555785_ChIP-Seq_MESCs_Mouse0.75022443
189TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73245134
190IRF1_19129219_ChIP-ChIP_H3396_Human0.70383290
191PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.70196333
192TCF3_18692474_ChIP-Seq_MEFs_Mouse0.68254272
193FOXP1_21924763_ChIP-Seq_HESCs_Human0.67307414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development6.72550539
2MP0003880_abnormal_central_pattern5.52442318
3MP0002876_abnormal_thyroid_physiology4.98547955
4MP0002254_reproductive_system_inflammat4.95489761
5MP0005645_abnormal_hypothalamus_physiol4.63578951
6MP0004859_abnormal_synaptic_plasticity3.61654518
7MP0003879_abnormal_hair_cell3.43537738
8MP0003635_abnormal_synaptic_transmissio2.97845223
9MP0001968_abnormal_touch/_nociception2.92176617
10MP0003890_abnormal_embryonic-extraembry2.85533852
11MP0009046_muscle_twitch2.73592914
12MP0003111_abnormal_nucleus_morphology2.72692016
13MP0009745_abnormal_behavioral_response2.71139838
14MP0004510_myositis2.66808708
15MP0000566_synostosis2.60752837
16MP0004957_abnormal_blastocyst_morpholog2.59534187
17MP0002063_abnormal_learning/memory/cond2.54804358
18MP0002064_seizures2.52139852
19MP0003693_abnormal_embryo_hatching2.45543070
20MP0008058_abnormal_DNA_repair2.42657129
21MP0000537_abnormal_urethra_morphology2.38667879
22MP0002272_abnormal_nervous_system2.34870567
23MP0002938_white_spotting2.34189651
24MP0001501_abnormal_sleep_pattern2.33213077
25MP0001348_abnormal_lacrimal_gland2.31622176
26MP0010030_abnormal_orbit_morphology2.31580992
27MP0003077_abnormal_cell_cycle2.31123377
28MP0003806_abnormal_nucleotide_metabolis2.30909359
29MP0002736_abnormal_nociception_after2.28859940
30MP0006276_abnormal_autonomic_nervous2.27231767
31MP0008932_abnormal_embryonic_tissue2.27123595
32MP0004270_analgesia2.26430221
33MP0010094_abnormal_chromosome_stability2.26351363
34MP0001346_abnormal_lacrimal_gland2.20344752
35MP0005310_abnormal_salivary_gland2.16322699
36MP0001440_abnormal_grooming_behavior2.15141821
37MP0002572_abnormal_emotion/affect_behav2.14126038
38MP0002734_abnormal_mechanical_nocicepti2.13940307
39MP0002102_abnormal_ear_morphology2.08203656
40MP0001529_abnormal_vocalization2.00264572
41MP0002735_abnormal_chemical_nociception1.97205736
42MP0010368_abnormal_lymphatic_system1.93419450
43MP0009697_abnormal_copulation1.93289368
44MP0000678_abnormal_parathyroid_gland1.91426450
45MP0002067_abnormal_sensory_capabilities1.81531901
46MP0002733_abnormal_thermal_nociception1.79884419
47MP0000049_abnormal_middle_ear1.79251438
48MP0000762_abnormal_tongue_morphology1.76429621
49MP0001486_abnormal_startle_reflex1.75807421
50MP0009053_abnormal_anal_canal1.70605463
51MP0003786_premature_aging1.69930355
52MP0002132_abnormal_respiratory_system1.69739361
53MP0008569_lethality_at_weaning1.67185261
54MP0001970_abnormal_pain_threshold1.58933005
55MP0000685_abnormal_immune_system1.55622574
56MP0002234_abnormal_pharynx_morphology1.52785546
57MP0008789_abnormal_olfactory_epithelium1.52706698
58MP0001879_abnormal_lymphatic_vessel1.51909348
59MP0004264_abnormal_extraembryonic_tissu1.50798307
60MP0003329_amyloid_beta_deposits1.49095521
61MP0000778_abnormal_nervous_system1.48981883
62MP0003937_abnormal_limbs/digits/tail_de1.44864811
63MP0004924_abnormal_behavior1.43125284
64MP0005386_behavior/neurological_phenoty1.43125284
65MP0002184_abnormal_innervation1.43077427
66MP0005499_abnormal_olfactory_system1.41616963
67MP0005394_taste/olfaction_phenotype1.41616963
68MP0002163_abnormal_gland_morphology1.39780859
69MP0009250_abnormal_appendicular_skeleto1.39658017
70MP0005423_abnormal_somatic_nervous1.39603926
71MP0002557_abnormal_social/conspecific_i1.39190720
72MP0006292_abnormal_olfactory_placode1.35628702
73MP0008007_abnormal_cellular_replicative1.35061474
74MP0006036_abnormal_mitochondrial_physio1.35025179
75MP0001730_embryonic_growth_arrest1.34838187
76MP0010386_abnormal_urinary_bladder1.34021586
77MP0003186_abnormal_redox_activity1.33690880
78MP0002837_dystrophic_cardiac_calcinosis1.33549811
79MP0000350_abnormal_cell_proliferation1.33345550
80MP0002638_abnormal_pupillary_reflex1.32376075
81MP0004142_abnormal_muscle_tone1.31800886
82MP0009379_abnormal_foot_pigmentation1.31504950
83MP0009780_abnormal_chondrocyte_physiolo1.31183303
84MP0003385_abnormal_body_wall1.27709195
85MP0004272_abnormal_basement_membrane1.25318739
86MP0003718_maternal_effect1.23782927
87MP0001984_abnormal_olfaction1.23498256
88MP0003122_maternal_imprinting1.19334058
89MP0004145_abnormal_muscle_electrophysio1.18020884
90MP0002249_abnormal_larynx_morphology1.17306945
91MP0002084_abnormal_developmental_patter1.16750332
92MP0002066_abnormal_motor_capabilities/c1.15977224
93MP0001963_abnormal_hearing_physiology1.15870735
94MP0008874_decreased_physiological_sensi1.15677095
95MP0001672_abnormal_embryogenesis/_devel1.14859173
96MP0005380_embryogenesis_phenotype1.14859173
97MP0003942_abnormal_urinary_system1.14543993
98MP0003755_abnormal_palate_morphology1.11890375
99MP0005501_abnormal_skin_physiology1.11383860
100MP0001697_abnormal_embryo_size1.10402676
101MP0002697_abnormal_eye_size1.09699188
102MP0002177_abnormal_outer_ear1.08718639
103MP0008995_early_reproductive_senescence1.08568322
104MP0001485_abnormal_pinna_reflex1.08308648
105MP0005379_endocrine/exocrine_gland_phen1.08223150
106MP0005646_abnormal_pituitary_gland1.06361536
107MP0005389_reproductive_system_phenotype1.05389393
108MP0002233_abnormal_nose_morphology1.05125536
109MP0000733_abnormal_muscle_development1.03952264
110MP0006035_abnormal_mitochondrial_morpho1.03640324
111MP0001849_ear_inflammation1.03223307
112MP0003123_paternal_imprinting1.01846330
113MP0002111_abnormal_tail_morphology0.99876468
114MP0003984_embryonic_growth_retardation0.99866033
115MP0002085_abnormal_embryonic_tissue0.99271669
116MP0002796_impaired_skin_barrier0.99213009
117MP0002653_abnormal_ependyma_morphology0.97772139
118MP0002088_abnormal_embryonic_growth/wei0.96708731
119MP0003567_abnormal_fetal_cardiomyocyte0.96235475
120MP0002160_abnormal_reproductive_system0.94346730
121MP0002882_abnormal_neuron_morphology0.93232916
122MP0000026_abnormal_inner_ear0.92132540
123MP0000604_amyloidosis0.90847672
124MP0005330_cardiomyopathy0.90511716
125MP0004484_altered_response_of0.89682810
126MP0001764_abnormal_homeostasis0.89545117
127MP0003011_delayed_dark_adaptation0.88706139
128MP0002277_abnormal_respiratory_mucosa0.88469835
129MP0003315_abnormal_perineum_morphology0.88096560
130MP0006082_CNS_inflammation0.86684087
131MP0004133_heterotaxia0.86194236
132MP0000358_abnormal_cell_content/0.85964782
133MP0000467_abnormal_esophagus_morphology0.85825401
134MP0002069_abnormal_eating/drinking_beha0.85460984
135MP0008872_abnormal_physiological_respon0.85298832
136MP0001727_abnormal_embryo_implantation0.84969230
137MP0000003_abnormal_adipose_tissue0.84533411
138MP0001502_abnormal_circadian_rhythm0.82962728
139MP0004885_abnormal_endolymph0.82848466
140MP0002080_prenatal_lethality0.82674147
141MP0003705_abnormal_hypodermis_morpholog0.82383801
142MP0003935_abnormal_craniofacial_develop0.81886480
143MP0006138_congestive_heart_failure0.80754594
144MP0001905_abnormal_dopamine_level0.79652515
145MP0001293_anophthalmia0.79394508
146MP0006072_abnormal_retinal_apoptosis0.78201169
147* MP0002114_abnormal_axial_skeleton0.76605116
148MP0003121_genomic_imprinting0.74996072
149MP0000579_abnormal_nail_morphology0.73881477
150MP0000751_myopathy0.72853101
151MP0005551_abnormal_eye_electrophysiolog0.72745919
152MP0000955_abnormal_spinal_cord0.72685085
153MP0000534_abnormal_ureter_morphology0.72412105
154MP0004742_abnormal_vestibular_system0.72283411
155MP0001835_abnormal_antigen_presentation0.70875146
156MP0008004_abnormal_stomach_pH0.69259201
157MP0000538_abnormal_urinary_bladder0.69202685
158MP0003137_abnormal_impulse_conducting0.68960190
159MP0004811_abnormal_neuron_physiology0.68868776
160MP0002229_neurodegeneration0.68847459
161MP0002932_abnormal_joint_morphology0.68725937
162MP0001270_distended_abdomen0.68186512
163MP0005623_abnormal_meninges_morphology0.68087191
164MP0004215_abnormal_myocardial_fiber0.66129573
165MP0002086_abnormal_extraembryonic_tissu0.65734283
166MP0003959_abnormal_lean_body0.63913239
167MP0000920_abnormal_myelination0.63898521
168MP0002822_catalepsy0.63715506
169MP0001943_abnormal_respiration0.63272881
170MP0002971_abnormal_brown_adipose0.63228069
171MP0004858_abnormal_nervous_system0.62377353
172MP0002752_abnormal_somatic_nervous0.61657787
173MP0002877_abnormal_melanocyte_morpholog0.61345210
174MP0001177_atelectasis0.61032805
175MP0008057_abnormal_DNA_replication0.61005805
176MP0004085_abnormal_heartbeat0.60808250
177MP0001664_abnormal_digestion0.59647104
178MP0001873_stomach_inflammation0.58623021
179MP0005535_abnormal_body_temperature0.58563218
180MP0003631_nervous_system_phenotype0.56165225
181MP0003633_abnormal_nervous_system0.55901040
182MP0002152_abnormal_brain_morphology0.55644836
183MP0003638_abnormal_response/metabolism_0.52953206
184MP0003787_abnormal_imprinting0.48709939
185MP0005620_abnormal_muscle_contractility0.48529908
186MP0001188_hyperpigmentation0.47920387

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.26144574
2Atonic seizures (HP:0010819)5.56732167
3Epileptic encephalopathy (HP:0200134)4.89273897
4Febrile seizures (HP:0002373)4.62560216
5Focal seizures (HP:0007359)4.49301116
6Type I diabetes mellitus (HP:0100651)4.46446673
7Absence seizures (HP:0002121)4.34270439
8Upper limb muscle weakness (HP:0003484)4.20530573
9Abnormal pupillary function (HP:0007686)4.18897590
10Hyperventilation (HP:0002883)4.18452858
11Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.91998613
12Acute necrotizing encephalopathy (HP:0006965)3.88503510
13Generalized tonic-clonic seizures (HP:0002069)3.69240980
14Abnormal mitochondria in muscle tissue (HP:0008316)3.50466959
15Myokymia (HP:0002411)3.49932828
16Dialeptic seizures (HP:0011146)3.43833832
17Macrocytic anemia (HP:0001972)3.42592909
18Reticulocytopenia (HP:0001896)3.41945976
19Increased hepatocellular lipid droplets (HP:0006565)3.40599947
20Progressive macrocephaly (HP:0004481)3.34255926
21Progressive cerebellar ataxia (HP:0002073)3.32573725
22Tongue fasciculations (HP:0001308)3.12113255
23Acute encephalopathy (HP:0006846)3.11670170
24Onycholysis (HP:0001806)3.08112867
25Abnormality of cells of the erythroid lineage (HP:0012130)3.06747864
26Broad-based gait (HP:0002136)3.06176451
27Neurofibrillary tangles (HP:0002185)3.01207270
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.00586987
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.00586987
30Neoplasm of head and neck (HP:0012288)2.98471924
31Esophageal neoplasm (HP:0100751)2.98471924
32Type 2 muscle fiber atrophy (HP:0003554)2.98328869
33Abnormal hair whorl (HP:0010721)2.96867771
34Aplasia/Hypoplasia of the spleen (HP:0010451)2.95504827
35Double outlet right ventricle (HP:0001719)2.92138560
36Congenital malformation of the right heart (HP:0011723)2.92138560
37Abnormal eating behavior (HP:0100738)2.91863369
38Mitochondrial inheritance (HP:0001427)2.90842414
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.87867784
40Lipid accumulation in hepatocytes (HP:0006561)2.82660301
41Periauricular skin pits (HP:0100277)2.81799641
42Preauricular pit (HP:0004467)2.81799641
43Increased intramyocellular lipid droplets (HP:0012240)2.81697265
44Humeroradial synostosis (HP:0003041)2.75095482
45Synostosis involving the elbow (HP:0003938)2.75095482
46Palpitations (HP:0001962)2.72662921
47Renal Fanconi syndrome (HP:0001994)2.72274608
48Epileptiform EEG discharges (HP:0011182)2.72125244
49Cerebral inclusion bodies (HP:0100314)2.71372627
50Muscle fibrillation (HP:0010546)2.71013267
51Poor eye contact (HP:0000817)2.69658565
52Gait imbalance (HP:0002141)2.67540936
53Birth length less than 3rd percentile (HP:0003561)2.64300586
54Abnormality of renal resorption (HP:0011038)2.63780040
55Dysdiadochokinesis (HP:0002075)2.61030039
56Impaired social interactions (HP:0000735)2.60427347
57Abnormal social behavior (HP:0012433)2.60427347
58Patent foramen ovale (HP:0001655)2.60379074
59Polyphagia (HP:0002591)2.58810605
60Amblyopia (HP:0000646)2.57831419
61Abnormal auditory evoked potentials (HP:0006958)2.56949735
62Supranuclear gaze palsy (HP:0000605)2.54645453
63Visual hallucinations (HP:0002367)2.53370901
64Abnormality of the fetal cardiovascular system (HP:0010948)2.52503867
65Abnormal umbilical cord blood vessels (HP:0011403)2.52503867
66Single umbilical artery (HP:0001195)2.52503867
67EEG with generalized epileptiform discharges (HP:0011198)2.50042974
68Lip pit (HP:0100267)2.50033524
69Abnormal number of erythroid precursors (HP:0012131)2.49261511
70Impaired vibration sensation in the lower limbs (HP:0002166)2.48561136
71Increased CSF lactate (HP:0002490)2.48240919
72Increased serum lactate (HP:0002151)2.47906076
73Medial flaring of the eyebrow (HP:0010747)2.47834860
74Pili torti (HP:0003777)2.47567693
75Septate vagina (HP:0001153)2.46548881
76Stenosis of the external auditory canal (HP:0000402)2.46148953
77Abnormality of cochlea (HP:0000375)2.45544860
78Congenital primary aphakia (HP:0007707)2.45221970
79Fragile nails (HP:0001808)2.44618375
80Exercise intolerance (HP:0003546)2.44128077
81Testicular atrophy (HP:0000029)2.43602445
82Excessive salivation (HP:0003781)2.43193243
83Drooling (HP:0002307)2.43193243
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41739359
85Abnormality of alanine metabolism (HP:0010916)2.41739359
86Hyperalaninemia (HP:0003348)2.41739359
87Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41736207
88Keratoconjunctivitis (HP:0001096)2.40157287
89Truncal ataxia (HP:0002078)2.40021546
90Hepatic necrosis (HP:0002605)2.37772227
91Hyperglycemia (HP:0003074)2.36954187
92Decreased muscle mass (HP:0003199)2.36571836
93Muscle fiber atrophy (HP:0100295)2.36562300
94Truncus arteriosus (HP:0001660)2.36257945
95Chromsome breakage (HP:0040012)2.35680546
96Increased IgM level (HP:0003496)2.35054515
97Oligodontia (HP:0000677)2.33037180
98Asplenia (HP:0001746)2.29243218
99Dysmetria (HP:0001310)2.29027477
100Scanning speech (HP:0002168)2.28873309
101Abnormality of binocular vision (HP:0011514)2.28644025
102Diplopia (HP:0000651)2.28644025
103Hypoplastic left heart (HP:0004383)2.27197038
104Termporal pattern (HP:0011008)2.26361368
105Insidious onset (HP:0003587)2.26361368
106Hypsarrhythmia (HP:0002521)2.25213926
107Optic disc pallor (HP:0000543)2.25082120
108Lactic acidosis (HP:0003128)2.24698975
109Paralysis (HP:0003470)2.23113729
110Congenital, generalized hypertrichosis (HP:0004540)2.22725946
111Hydroxyprolinuria (HP:0003080)2.21279248
112Abnormality of proline metabolism (HP:0010907)2.21279248
113Abnormality of calcium-phosphate metabolism (HP:0100530)2.20125619
114Hemiparesis (HP:0001269)2.19813631
115Increased serum pyruvate (HP:0003542)2.18980599
116Increased muscle lipid content (HP:0009058)2.16210967
117Abnormality of salivation (HP:0100755)2.15698469
118Cerebral edema (HP:0002181)2.15468457
1193-Methylglutaconic aciduria (HP:0003535)2.14967707
120Abnormality of the renal collecting system (HP:0004742)2.13516177
121Vaginal atresia (HP:0000148)2.12429868
122Anxiety (HP:0000739)2.12411428
123Respiratory failure (HP:0002878)2.12291298
124Pallor (HP:0000980)2.12178822
125Abnormal lung lobation (HP:0002101)2.11925532
126Abnormality of the umbilical cord (HP:0010881)2.11758760
127Inability to walk (HP:0002540)2.11752474
128Exertional dyspnea (HP:0002875)2.11184660
129Microvesicular hepatic steatosis (HP:0001414)2.11116351
130Generalized myoclonic seizures (HP:0002123)2.08647696
131Genetic anticipation (HP:0003743)2.08395781
132Oral leukoplakia (HP:0002745)2.07317111
133Skin pits (HP:0100276)2.06649884
134Genital tract atresia (HP:0001827)2.06558775
135Sparse eyelashes (HP:0000653)2.05662248
136Respiratory difficulties (HP:0002880)2.05301979
137Osteomalacia (HP:0002749)2.05276204
138Nephrogenic diabetes insipidus (HP:0009806)2.05126620
139Protruding tongue (HP:0010808)2.04967251
140Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04303831
141Degeneration of the lateral corticospinal tracts (HP:0002314)2.04303831
142Hepatocellular necrosis (HP:0001404)2.04205765
143Type I transferrin isoform profile (HP:0003642)2.02020134
144Annular pancreas (HP:0001734)2.00593843
145Hypoventilation (HP:0002791)2.00391330
146Amniotic constriction ring (HP:0009775)1.98714252
147Abnormality of placental membranes (HP:0011409)1.98714252
148Abnormality of glycolysis (HP:0004366)1.98236084
149Facial cleft (HP:0002006)1.97077031
150Fatigable weakness (HP:0003473)1.96202910
151Abnormality of the neuromuscular junction (HP:0003398)1.96202910
152Progressive muscle weakness (HP:0003323)1.96114994
153Muscle hypertrophy of the lower extremities (HP:0008968)1.95976627
154Cerebral hypomyelination (HP:0006808)1.95610698
155X-linked dominant inheritance (HP:0001423)1.95432174
156Abnormal number of incisors (HP:0011064)1.94154314
157Specific learning disability (HP:0001328)1.94073485
158Status epilepticus (HP:0002133)1.93562670
159Symphalangism affecting the phalanges of the hand (HP:0009773)1.93117877
160Abnormalities of placenta or umbilical cord (HP:0001194)1.92832364
161Leukodystrophy (HP:0002415)1.92319218
162Abnormality of the anterior horn cell (HP:0006802)1.91056221
163Degeneration of anterior horn cells (HP:0002398)1.91056221
164Hypercortisolism (HP:0001578)1.90949020
165Milia (HP:0001056)1.89483294
166Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88771989
167Hyperthyroidism (HP:0000836)1.87532643
168Abnormality of serum amino acid levels (HP:0003112)1.86162818
169Progressive inability to walk (HP:0002505)1.84485248
170Absent thumb (HP:0009777)1.84283604
171Gout (HP:0001997)1.83488083
172Megaloblastic anemia (HP:0001889)1.82658492
173Meckel diverticulum (HP:0002245)1.81658336
174Plantar hyperkeratosis (HP:0007556)1.81241152
175Small hand (HP:0200055)1.80705627
176Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.79893986
177Hypoplasia of the uterus (HP:0000013)1.79704480
178Broad alveolar ridges (HP:0000187)1.78580193
179Abnormality of the distal phalanges of the toes (HP:0010182)1.78421211
180Rimmed vacuoles (HP:0003805)1.78024651
181Abnormality of the preputium (HP:0100587)1.77034915
182Autoamputation (HP:0001218)1.76068642
183Selective tooth agenesis (HP:0001592)1.75867749
184Abnormality of the ileum (HP:0001549)1.75188890
185Poor suck (HP:0002033)1.75135202
186Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.74372966
187Esotropia (HP:0000565)1.74321151
188Short middle phalanx of the 5th finger (HP:0004220)1.74195688
189Aplasia/hypoplasia of the uterus (HP:0008684)1.72250671
190Proximal placement of thumb (HP:0009623)1.69356347
191Abnormality of the labia minora (HP:0012880)1.69251838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.63134919
2CASK4.28054529
3NTRK33.99238676
4NME23.88149808
5RIPK43.47036849
6CDC73.33951014
7MAP3K123.28368182
8SRPK13.24112476
9NEK12.90460073
10BMPR22.85088628
11PBK2.72493467
12NME12.68833595
13EPHA42.53928253
14PLK22.51031518
15PDK22.43187473
16BCR2.40638712
17MAP2K72.35120418
18MAP3K42.29106372
19DYRK1B2.23140167
20MAP3K92.21426229
21MAP3K132.15392655
22WEE12.08505222
23DAPK22.03013509
24PNCK1.97875205
25TRIM281.95317999
26PLK41.89187380
27GRK51.86762038
28MINK11.84791035
29TTK1.84517942
30PIM21.81312138
31STK161.79424434
32TNIK1.74687880
33CDK191.63615940
34MST41.63035068
35MAP2K41.53837995
36NTRK11.47828452
37CCNB11.47158696
38OXSR11.43976820
39PLK11.43322837
40MARK11.39834824
41VRK21.39140743
42TSSK61.36349522
43DAPK11.35890506
44EIF2AK11.34405001
45NTRK21.28190313
46EIF2AK31.25247002
47MAP3K141.23406985
48KDR1.22602026
49PKN11.21345107
50IRAK41.20084653
51OBSCN1.19633725
52ARAF1.19361419
53AURKA1.17971684
54CAMK2A1.16553100
55CDK51.14867861
56MAPK131.11347849
57PRKCG1.11096229
58AURKB1.08674114
59BRSK11.07613222
60BRSK21.05078681
61ERBB31.04230540
62PLK31.03939198
63VRK11.03690097
64SIK21.00930534
65TLK10.99968186
66CSNK1G30.99414912
67STK40.98845283
68IRAK30.98118359
69PHKG20.96826567
70PHKG10.96826567
71FES0.95768644
72CSNK1G10.95674850
73ZAK0.94929913
74GRK70.91708413
75ADRBK20.90891070
76AKT30.90672863
77BRAF0.90442067
78CAMK2B0.88500940
79ABL20.87595256
80PRKCE0.87203708
81CHEK20.87200120
82LMTK20.84565226
83PAK40.84514736
84FLT30.82072054
85CDK70.81956029
86PRPF4B0.80760480
87PAK60.78234789
88DYRK30.77728543
89ERBB40.77050611
90UHMK10.75238562
91CHEK10.75106216
92MAPKAPK50.73336419
93TAF10.72992096
94KSR10.72741561
95AKT20.71864752
96CAMKK20.71682439
97SIK30.71164966
98BMPR1B0.70557002
99CSNK1A1L0.70414337
100MST1R0.69918340
101GRK10.69474086
102SCYL20.69244006
103ATR0.67234828
104RPS6KC10.66642171
105RPS6KL10.66642171
106SGK10.66210142
107PASK0.65865207
108MKNK10.65662407
109CSNK1G20.64011870
110CSNK2A10.63696167
111RPS6KA60.63512605
112MYLK0.63247595
113ROCK20.62532022
114DYRK1A0.61417526
115CAMK2D0.60153441
116ADRBK10.58758416
117RPS6KA50.58411484
118ATM0.56442174
119PTK2B0.56307190
120ILK0.56039441
121CSNK2A20.54728105
122EPHA20.54561507
123TGFBR10.53123846
124MAP3K20.52983087
125CAMK1G0.52884637
126CAMK2G0.51896546
127PAK30.51787110
128STK390.50769536
129PDK40.50659475
130PDK30.50659475
131SYK0.50559363
132RPS6KA10.49866615
133PRKCQ0.49403539
134RPS6KA20.48643491
135MAP3K30.47497029
136MAPK120.47458872
137CAMKK10.46206194
138PDK10.46149986
139CDK140.45688643
140PDPK10.45299694
141CDK180.44819275
142CDK20.44680431
143CAMK10.44595597
144DYRK20.44173044
145LATS10.44054159
146GRK60.43376750
147MAP3K110.41536636
148CDK10.41218442
149MAP3K50.40955626
150PRKACA0.40941138
151MOS0.40639321
152STK110.40054340
153CDK80.39709889
154IRAK20.38740976
155TIE10.38571991
156CDK150.38310789
157PRKCA0.38291523
158RPS6KB20.38174417
159CDK30.37809615
160PRKCB0.37103120
161CSNK1E0.36507450
162MET0.36304291
163CLK10.35664142
164IRAK10.35042395
165PRKCD0.34735021
166CDK90.34649218
167CSNK1A10.34635161
168MKNK20.34614409
169RPS6KA30.33190624
170PRKCZ0.32506327
171KSR20.32345741
172DAPK30.31865099
173PRKDC0.30807693
174FYN0.30437514
175STK30.30413381

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.14241514
2Nicotine addiction_Homo sapiens_hsa050334.20230505
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.07046078
4DNA replication_Homo sapiens_hsa030303.84644029
5Proteasome_Homo sapiens_hsa030503.25857365
6Mismatch repair_Homo sapiens_hsa034303.13786953
7Synaptic vesicle cycle_Homo sapiens_hsa047213.11470355
8Oxidative phosphorylation_Homo sapiens_hsa001903.10874939
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06164410
10Base excision repair_Homo sapiens_hsa034103.06085046
11RNA polymerase_Homo sapiens_hsa030203.03801853
12Collecting duct acid secretion_Homo sapiens_hsa049662.96479011
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66752359
14GABAergic synapse_Homo sapiens_hsa047272.51082846
15Morphine addiction_Homo sapiens_hsa050322.29146654
16Glutamatergic synapse_Homo sapiens_hsa047242.24574180
17Pyrimidine metabolism_Homo sapiens_hsa002402.22555737
18Spliceosome_Homo sapiens_hsa030402.21545967
19Olfactory transduction_Homo sapiens_hsa047402.15083209
20Nucleotide excision repair_Homo sapiens_hsa034202.12594528
21Long-term potentiation_Homo sapiens_hsa047202.12181124
22Circadian entrainment_Homo sapiens_hsa047132.09293789
23Vibrio cholerae infection_Homo sapiens_hsa051102.08127796
24One carbon pool by folate_Homo sapiens_hsa006702.06852526
25Taste transduction_Homo sapiens_hsa047422.06713783
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05771587
27Homologous recombination_Homo sapiens_hsa034402.05430299
28Alzheimers disease_Homo sapiens_hsa050102.01140207
29Parkinsons disease_Homo sapiens_hsa050121.99241818
30RNA degradation_Homo sapiens_hsa030181.95630999
31Salivary secretion_Homo sapiens_hsa049701.94809998
32RNA transport_Homo sapiens_hsa030131.94157583
33Amphetamine addiction_Homo sapiens_hsa050311.91554409
34Renin secretion_Homo sapiens_hsa049241.88401658
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86114685
36Cell cycle_Homo sapiens_hsa041101.79138243
37Serotonergic synapse_Homo sapiens_hsa047261.66504335
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62505230
39Cardiac muscle contraction_Homo sapiens_hsa042601.61559687
40Long-term depression_Homo sapiens_hsa047301.60043443
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56741443
42Non-homologous end-joining_Homo sapiens_hsa034501.51062461
43Fanconi anemia pathway_Homo sapiens_hsa034601.50816090
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.50103539
45Dopaminergic synapse_Homo sapiens_hsa047281.47292114
46Calcium signaling pathway_Homo sapiens_hsa040201.46084250
47Huntingtons disease_Homo sapiens_hsa050161.44151560
48Gastric acid secretion_Homo sapiens_hsa049711.40517793
49Purine metabolism_Homo sapiens_hsa002301.37291394
50Phenylalanine metabolism_Homo sapiens_hsa003601.37280840
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35094971
52Basal transcription factors_Homo sapiens_hsa030221.30364100
53Steroid biosynthesis_Homo sapiens_hsa001001.30162923
54Glutathione metabolism_Homo sapiens_hsa004801.28875854
55Oxytocin signaling pathway_Homo sapiens_hsa049211.28650164
56Phototransduction_Homo sapiens_hsa047441.24001493
57Cholinergic synapse_Homo sapiens_hsa047251.23089234
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21740509
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20882659
60Insulin secretion_Homo sapiens_hsa049111.17290447
61Rheumatoid arthritis_Homo sapiens_hsa053231.12493879
62Vitamin B6 metabolism_Homo sapiens_hsa007501.10815930
63Fatty acid elongation_Homo sapiens_hsa000621.04746215
64Cyanoamino acid metabolism_Homo sapiens_hsa004601.02938301
65African trypanosomiasis_Homo sapiens_hsa051431.02845894
66p53 signaling pathway_Homo sapiens_hsa041150.99953152
67Cocaine addiction_Homo sapiens_hsa050300.99534224
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99486329
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99224754
70Pyruvate metabolism_Homo sapiens_hsa006200.97286387
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96620223
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95358219
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93705347
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91141782
75Folate biosynthesis_Homo sapiens_hsa007900.87525166
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86726856
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85800315
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85431300
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83998193
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83335048
81Biosynthesis of amino acids_Homo sapiens_hsa012300.82962531
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.81285800
83GnRH signaling pathway_Homo sapiens_hsa049120.78061603
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77456929
85Phagosome_Homo sapiens_hsa041450.77101946
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76862326
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76377388
88Type I diabetes mellitus_Homo sapiens_hsa049400.75702412
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75538629
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75260912
91mRNA surveillance pathway_Homo sapiens_hsa030150.74859113
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74587863
93Gap junction_Homo sapiens_hsa045400.72896234
94Selenocompound metabolism_Homo sapiens_hsa004500.69981848
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69906199
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.69889467
97Oocyte meiosis_Homo sapiens_hsa041140.69573220
98Melanogenesis_Homo sapiens_hsa049160.67098596
99Dilated cardiomyopathy_Homo sapiens_hsa054140.66723051
100Metabolic pathways_Homo sapiens_hsa011000.66126531
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66029968
102Axon guidance_Homo sapiens_hsa043600.65231896
103cAMP signaling pathway_Homo sapiens_hsa040240.64749969
104Sulfur metabolism_Homo sapiens_hsa009200.64482182
105Carbon metabolism_Homo sapiens_hsa012000.64083288
106Mineral absorption_Homo sapiens_hsa049780.62987065
107MAPK signaling pathway_Homo sapiens_hsa040100.62150827
108TGF-beta signaling pathway_Homo sapiens_hsa043500.61507068
109Arginine and proline metabolism_Homo sapiens_hsa003300.59828779
110Estrogen signaling pathway_Homo sapiens_hsa049150.59635142
111Melanoma_Homo sapiens_hsa052180.57802912
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56395131
113Thyroid hormone synthesis_Homo sapiens_hsa049180.56270631
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56144570
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.55356404
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.54041717
117Chemical carcinogenesis_Homo sapiens_hsa052040.52724502
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51078284
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50716554
120Tyrosine metabolism_Homo sapiens_hsa003500.50464535
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48779312
122Ras signaling pathway_Homo sapiens_hsa040140.48468174
123Propanoate metabolism_Homo sapiens_hsa006400.47142881
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45447637
125Fructose and mannose metabolism_Homo sapiens_hsa000510.43697035
126Pentose phosphate pathway_Homo sapiens_hsa000300.42448583
127Pancreatic secretion_Homo sapiens_hsa049720.41685464
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41618231
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40099637
130Vitamin digestion and absorption_Homo sapiens_hsa049770.39936907
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38689655
132Type II diabetes mellitus_Homo sapiens_hsa049300.37119198
133Galactose metabolism_Homo sapiens_hsa000520.35866989
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.35716254
135N-Glycan biosynthesis_Homo sapiens_hsa005100.35524694
136Hippo signaling pathway_Homo sapiens_hsa043900.35465757
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34948143
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34507309
139Autoimmune thyroid disease_Homo sapiens_hsa053200.34476969
140Histidine metabolism_Homo sapiens_hsa003400.34318200
141Wnt signaling pathway_Homo sapiens_hsa043100.32621150
142Butanoate metabolism_Homo sapiens_hsa006500.32552934
143Small cell lung cancer_Homo sapiens_hsa052220.31355679
144Ether lipid metabolism_Homo sapiens_hsa005650.30684924
145Fatty acid degradation_Homo sapiens_hsa000710.29836673
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28357352
147Basal cell carcinoma_Homo sapiens_hsa052170.27499054
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26533604
149NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25803295
150Rap1 signaling pathway_Homo sapiens_hsa040150.24894531
151Arginine biosynthesis_Homo sapiens_hsa002200.24619336
152ErbB signaling pathway_Homo sapiens_hsa040120.24142277
153Glioma_Homo sapiens_hsa052140.24057821
154Glucagon signaling pathway_Homo sapiens_hsa049220.24006183
155Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23230560
156Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23186919
157Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22597927
158ECM-receptor interaction_Homo sapiens_hsa045120.22241846
159Lysine degradation_Homo sapiens_hsa003100.21672117
160Allograft rejection_Homo sapiens_hsa053300.20095405
161Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19526323
162Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17907481
163Phospholipase D signaling pathway_Homo sapiens_hsa040720.17848566
164Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17813491
165Circadian rhythm_Homo sapiens_hsa047100.17348569
166Peroxisome_Homo sapiens_hsa041460.16432054
167Antigen processing and presentation_Homo sapiens_hsa046120.15376753
168Prion diseases_Homo sapiens_hsa050200.14935719
169Retinol metabolism_Homo sapiens_hsa008300.14883747
170Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14756706
171Sulfur relay system_Homo sapiens_hsa041220.14290498
172Hedgehog signaling pathway_Homo sapiens_hsa043400.13537465
173Protein export_Homo sapiens_hsa030600.13364217
174Chemokine signaling pathway_Homo sapiens_hsa040620.12969288
175Inositol phosphate metabolism_Homo sapiens_hsa005620.12101207
176Glycerolipid metabolism_Homo sapiens_hsa005610.11185713
177Bladder cancer_Homo sapiens_hsa052190.09734884
178Alcoholism_Homo sapiens_hsa050340.09169113
179Nitrogen metabolism_Homo sapiens_hsa009100.08180949

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