

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 5.68284766 |
| 2 | nuclear pore organization (GO:0006999) | 5.38100221 |
| 3 | histone H3-K36 demethylation (GO:0070544) | 4.63689232 |
| 4 | pre-miRNA processing (GO:0031054) | 4.44734419 |
| 5 | mitotic sister chromatid cohesion (GO:0007064) | 4.41221586 |
| 6 | pore complex assembly (GO:0046931) | 4.35180068 |
| 7 | DNA unwinding involved in DNA replication (GO:0006268) | 3.96266346 |
| 8 | regulation of histone H3-K9 methylation (GO:0051570) | 3.93532398 |
| 9 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.93493609 |
| 10 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.93493609 |
| 11 | dosage compensation (GO:0007549) | 3.89730149 |
| 12 | mitotic nuclear envelope disassembly (GO:0007077) | 3.68825243 |
| 13 | V(D)J recombination (GO:0033151) | 3.67265429 |
| 14 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.61045338 |
| 15 | gene silencing by RNA (GO:0031047) | 3.54498120 |
| 16 | regulation of RNA export from nucleus (GO:0046831) | 3.53098482 |
| 17 | translesion synthesis (GO:0019985) | 3.53023170 |
| 18 | membrane disassembly (GO:0030397) | 3.51384249 |
| 19 | nuclear envelope disassembly (GO:0051081) | 3.51384249 |
| 20 | regulation of chromatin silencing (GO:0031935) | 3.50685225 |
| 21 | piRNA metabolic process (GO:0034587) | 3.42972257 |
| 22 | histone mRNA catabolic process (GO:0071044) | 3.39464700 |
| 23 | binding of sperm to zona pellucida (GO:0007339) | 3.36248554 |
| 24 | positive regulation of granulocyte differentiation (GO:0030854) | 3.33504092 |
| 25 | synaptonemal complex assembly (GO:0007130) | 3.31998368 |
| 26 | rRNA methylation (GO:0031167) | 3.31203173 |
| 27 | chromatin assembly (GO:0031497) | 3.30826023 |
| 28 | chromatin silencing (GO:0006342) | 3.30382072 |
| 29 | acrosome assembly (GO:0001675) | 3.30014292 |
| 30 | negative regulation of histone methylation (GO:0031061) | 3.26813736 |
| 31 | peptidyl-lysine dimethylation (GO:0018027) | 3.26335701 |
| 32 | regulation of histone H3-K27 methylation (GO:0061085) | 3.25233350 |
| 33 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.23969731 |
| 34 | heterochromatin organization (GO:0070828) | 3.23213799 |
| 35 | sperm-egg recognition (GO:0035036) | 3.23166355 |
| 36 | single strand break repair (GO:0000012) | 3.22779756 |
| 37 | negative thymic T cell selection (GO:0045060) | 3.21822968 |
| 38 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.19156124 |
| 39 | histone H4-K8 acetylation (GO:0043982) | 3.17174307 |
| 40 | histone H4-K5 acetylation (GO:0043981) | 3.17174307 |
| 41 | DNA duplex unwinding (GO:0032508) | 3.17173189 |
| 42 | DNA geometric change (GO:0032392) | 3.15876684 |
| 43 | male meiosis (GO:0007140) | 3.13715690 |
| 44 | synaptonemal complex organization (GO:0070193) | 3.13078940 |
| 45 | mitotic chromosome condensation (GO:0007076) | 3.09061302 |
| 46 | ribosome assembly (GO:0042255) | 3.07743863 |
| 47 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.07559414 |
| 48 | regulation of translational fidelity (GO:0006450) | 3.07076735 |
| 49 | DNA replication initiation (GO:0006270) | 3.06637320 |
| 50 | positive regulation of histone methylation (GO:0031062) | 3.04640635 |
| 51 | fusion of sperm to egg plasma membrane (GO:0007342) | 3.04304507 |
| 52 | regulation of histone methylation (GO:0031060) | 3.04203418 |
| 53 | negative regulation of DNA repair (GO:0045738) | 3.01621931 |
| 54 | sister chromatid cohesion (GO:0007062) | 3.01241791 |
| 55 | negative T cell selection (GO:0043383) | 3.01104824 |
| 56 | histone H4-K16 acetylation (GO:0043984) | 3.00686503 |
| 57 | regulation of chromatin binding (GO:0035561) | 3.00633029 |
| 58 | histone H3-K4 methylation (GO:0051568) | 3.00377090 |
| 59 | regulation of centriole replication (GO:0046599) | 3.00316811 |
| 60 | histone lysine demethylation (GO:0070076) | 2.99944729 |
| 61 | protein-DNA complex disassembly (GO:0032986) | 2.99543500 |
| 62 | nucleosome disassembly (GO:0006337) | 2.99543500 |
| 63 | protein localization to chromosome, centromeric region (GO:0071459) | 2.98246948 |
| 64 | DNA double-strand break processing (GO:0000729) | 2.97118524 |
| 65 | gene silencing (GO:0016458) | 2.97009203 |
| 66 | cell-cell recognition (GO:0009988) | 2.95522881 |
| 67 | regulation of translational termination (GO:0006449) | 2.93789318 |
| 68 | histone H2A acetylation (GO:0043968) | 2.93419123 |
| 69 | histone deubiquitination (GO:0016578) | 2.90009636 |
| 70 | regulation of histone H3-K4 methylation (GO:0051569) | 2.89395620 |
| 71 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.88718176 |
| 72 | histone H4 acetylation (GO:0043967) | 2.88299814 |
| 73 | protein localization to kinetochore (GO:0034501) | 2.87630308 |
| 74 | IMP biosynthetic process (GO:0006188) | 2.87514652 |
| 75 | positive regulation of histone H3-K4 methylation (GO:0051571) | 2.86701809 |
| 76 | postreplication repair (GO:0006301) | 2.86448797 |
| 77 | histone demethylation (GO:0016577) | 2.85809719 |
| 78 | nucleus organization (GO:0006997) | 2.84102504 |
| 79 | chromosome condensation (GO:0030261) | 2.84001322 |
| 80 | non-recombinational repair (GO:0000726) | 2.83985853 |
| 81 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.83985853 |
| 82 | RNA stabilization (GO:0043489) | 2.82998400 |
| 83 | mRNA stabilization (GO:0048255) | 2.82998400 |
| 84 | DNA conformation change (GO:0071103) | 2.82167460 |
| 85 | acrosome reaction (GO:0007340) | 2.80614731 |
| 86 | DNA packaging (GO:0006323) | 2.80599871 |
| 87 | histone H3-K9 methylation (GO:0051567) | 2.80174318 |
| 88 | positive regulation by host of viral transcription (GO:0043923) | 2.79587096 |
| 89 | regulation of DNA damage checkpoint (GO:2000001) | 2.78907745 |
| 90 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.78748961 |
| 91 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 2.78748961 |
| 92 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.78748961 |
| 93 | mRNA transport (GO:0051028) | 2.77506195 |
| 94 | mRNA splice site selection (GO:0006376) | 2.75989775 |
| 95 | ATP-dependent chromatin remodeling (GO:0043044) | 2.73307608 |
| 96 | negative regulation of mRNA metabolic process (GO:1903312) | 2.73174941 |
| 97 | DNA ligation (GO:0006266) | 2.71824036 |
| 98 | chromosome organization involved in meiosis (GO:0070192) | 2.71724224 |
| 99 | sister chromatid segregation (GO:0000819) | 2.71634407 |
| 100 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.71475509 |
| 101 | nuclear envelope organization (GO:0006998) | 2.70218295 |
| 102 | multicellular organism reproduction (GO:0032504) | 2.68208086 |
| 103 | regulation of centrosome cycle (GO:0046605) | 2.68178924 |
| 104 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.68116447 |
| 105 | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | 2.67704931 |
| 106 | regulation of gene silencing (GO:0060968) | 2.67234067 |
| 107 | chromatin assembly or disassembly (GO:0006333) | 2.66965841 |
| 108 | rRNA modification (GO:0000154) | 2.66960184 |
| 109 | mRNA cleavage (GO:0006379) | 2.66914192 |
| 110 | protein dealkylation (GO:0008214) | 2.66424815 |
| 111 | protein demethylation (GO:0006482) | 2.66424815 |
| 112 | poly(A)+ mRNA export from nucleus (GO:0016973) | 2.66038628 |
| 113 | negative regulation of RNA splicing (GO:0033119) | 2.63807833 |
| 114 | genitalia morphogenesis (GO:0035112) | 2.62397861 |
| 115 | regulation of chromosome segregation (GO:0051983) | 2.61050061 |
| 116 | histone H3-K4 trimethylation (GO:0080182) | 2.60401272 |
| 117 | NLS-bearing protein import into nucleus (GO:0006607) | 2.59581716 |
| 118 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.58371999 |
| 119 | histone H3 acetylation (GO:0043966) | 2.57953809 |
| 120 | negative regulation of histone modification (GO:0031057) | 2.57593422 |
| 121 | negative regulation of chromosome segregation (GO:0051985) | 2.57435610 |
| 122 | DNA strand elongation (GO:0022616) | 2.57431405 |
| 123 | ncRNA catabolic process (GO:0034661) | 2.56858398 |
| 124 | alternative mRNA splicing, via spliceosome (GO:0000380) | 2.56814225 |
| 125 | regulation of DNA endoreduplication (GO:0032875) | 2.56743242 |
| 126 | regulation of gene silencing by RNA (GO:0060966) | 2.56558062 |
| 127 | regulation of posttranscriptional gene silencing (GO:0060147) | 2.56558062 |
| 128 | regulation of gene silencing by miRNA (GO:0060964) | 2.56558062 |
| 129 | negative regulation of gene silencing (GO:0060969) | 2.55733840 |
| 130 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.55028170 |
| 131 | sperm motility (GO:0030317) | 2.54690241 |
| 132 | negative regulation of mRNA processing (GO:0050686) | 2.54033562 |
| 133 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.53853888 |
| 134 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.53853888 |
| 135 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.53853888 |
| 136 | negative regulation of sister chromatid segregation (GO:0033046) | 2.53853888 |
| 137 | mRNA export from nucleus (GO:0006406) | 2.52134278 |
| 138 | histone lysine methylation (GO:0034968) | 2.51429376 |
| 139 | somatic cell DNA recombination (GO:0016444) | 2.51230200 |
| 140 | somatic diversification of immune receptors via germline recombination within a single locus (GO:000 | 2.51230200 |
| 141 | negative regulation of gene expression, epigenetic (GO:0045814) | 2.51060730 |
| 142 | RNA export from nucleus (GO:0006405) | 2.50980387 |
| 143 | intra-S DNA damage checkpoint (GO:0031573) | 2.50930757 |
| 144 | COPII vesicle coating (GO:0048208) | 2.50716737 |
| 145 | protein K11-linked deubiquitination (GO:0035871) | 2.49721557 |
| 146 | DNA methylation (GO:0006306) | 2.49629163 |
| 147 | DNA alkylation (GO:0006305) | 2.49629163 |
| 148 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.49245727 |
| 149 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.49094077 |
| 150 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.49094077 |
| 151 | peptidyl-lysine trimethylation (GO:0018023) | 2.48773874 |
| 152 | histone exchange (GO:0043486) | 2.48759715 |
| 153 | positive regulation of gene expression, epigenetic (GO:0045815) | 2.48714369 |
| 154 | spindle assembly checkpoint (GO:0071173) | 2.48237839 |
| 155 | positive regulation of chromosome segregation (GO:0051984) | 2.47760305 |
| 156 | establishment of RNA localization (GO:0051236) | 2.47697841 |
| 157 | microtubule nucleation (GO:0007020) | 2.46475859 |
| 158 | positive T cell selection (GO:0043368) | 2.44723465 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.33892194 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.64803118 |
| 3 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 4.46323785 |
| 4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.86027596 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.76814980 |
| 6 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.34514027 |
| 7 | MYC_22102868_ChIP-Seq_BL_Human | 2.90290972 |
| 8 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.88775051 |
| 9 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.77484397 |
| 10 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.57728397 |
| 11 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.47085781 |
| 12 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.31594717 |
| 13 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.24248163 |
| 14 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.13786848 |
| 15 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.11658375 |
| 16 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.06488676 |
| 17 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 2.06037150 |
| 18 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.02142800 |
| 19 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.01713346 |
| 20 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.97344614 |
| 21 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.95259434 |
| 22 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.83215744 |
| 23 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.81188407 |
| 24 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.80858550 |
| 25 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.80258781 |
| 26 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.77326186 |
| 27 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.75248937 |
| 28 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.73466869 |
| 29 | * CIITA_25753668_ChIP-Seq_RAJI_Human | 1.69506454 |
| 30 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.64006484 |
| 31 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.60225098 |
| 32 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.54591392 |
| 33 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.53040725 |
| 34 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.52925921 |
| 35 | * XRN2_22483619_ChIP-Seq_HELA_Human | 1.51116654 |
| 36 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.49770597 |
| 37 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.49765411 |
| 38 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.48633299 |
| 39 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.48492589 |
| 40 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.47440701 |
| 41 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.46541113 |
| 42 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.46468362 |
| 43 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.46113577 |
| 44 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.45515283 |
| 45 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.42667812 |
| 46 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.42348719 |
| 47 | MAF_26560356_Chip-Seq_TH2_Human | 1.40292618 |
| 48 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.38644924 |
| 49 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.37026254 |
| 50 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.33910028 |
| 51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.33561408 |
| 52 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.31599612 |
| 53 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.30647737 |
| 54 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.30021800 |
| 55 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.29999241 |
| 56 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.29942674 |
| 57 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.23490598 |
| 58 | MYB_26560356_Chip-Seq_TH2_Human | 1.23330769 |
| 59 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.22271440 |
| 60 | UTX_26944678_Chip-Seq_JUKART_Human | 1.22121975 |
| 61 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.20302920 |
| 62 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.19840542 |
| 63 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.19608517 |
| 64 | MYB_26560356_Chip-Seq_TH1_Human | 1.18741309 |
| 65 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.18051057 |
| 66 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.17574717 |
| 67 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.16979683 |
| 68 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.15996116 |
| 69 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.14437700 |
| 70 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.13668595 |
| 71 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.13652610 |
| 72 | MAF_26560356_Chip-Seq_TH1_Human | 1.13567344 |
| 73 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.13254179 |
| 74 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.12813788 |
| 75 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.12362217 |
| 76 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.12288130 |
| 77 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.12279009 |
| 78 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.11948050 |
| 79 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.09628001 |
| 80 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.09628001 |
| 81 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.09628001 |
| 82 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.09435237 |
| 83 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.09219306 |
| 84 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.06042919 |
| 85 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.05142666 |
| 86 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.05063233 |
| 87 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.02462609 |
| 88 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.02231734 |
| 89 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.02092548 |
| 90 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.01913165 |
| 91 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.01818602 |
| 92 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.00832544 |
| 93 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.00723292 |
| 94 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.00640396 |
| 95 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.00354404 |
| 96 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.99780549 |
| 97 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.99333356 |
| 98 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.99288187 |
| 99 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.98310017 |
| 100 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.97643870 |
| 101 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.95610438 |
| 102 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.95291726 |
| 103 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.94411455 |
| 104 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.94158829 |
| 105 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.94074240 |
| 106 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.93747844 |
| 107 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93329808 |
| 108 | * RUNX1_22412390_ChIP-Seq_EML_Mouse | 0.92844021 |
| 109 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.91965753 |
| 110 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 0.91774789 |
| 111 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.91496807 |
| 112 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.91412030 |
| 113 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.90142743 |
| 114 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 0.89286239 |
| 115 | * SPI1_23547873_ChIP-Seq_NB4_Human | 0.88759665 |
| 116 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.87842376 |
| 117 | * HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.87809122 |
| 118 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 0.85902822 |
| 119 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.85505263 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 3.19275409 |
| 2 | MP0010094_abnormal_chromosome_stability | 3.14928143 |
| 3 | MP0008007_abnormal_cellular_replicative | 3.03629168 |
| 4 | MP0008877_abnormal_DNA_methylation | 2.94424001 |
| 5 | MP0005410_abnormal_fertilization | 2.81859977 |
| 6 | MP0003111_abnormal_nucleus_morphology | 2.80257350 |
| 7 | MP0010352_gastrointestinal_tract_polyps | 2.76113980 |
| 8 | MP0003077_abnormal_cell_cycle | 2.71546103 |
| 9 | MP0004957_abnormal_blastocyst_morpholog | 2.52902229 |
| 10 | MP0003693_abnormal_embryo_hatching | 2.46362213 |
| 11 | MP0008058_abnormal_DNA_repair | 2.40478574 |
| 12 | MP0005076_abnormal_cell_differentiation | 2.31621894 |
| 13 | MP0010307_abnormal_tumor_latency | 2.28935707 |
| 14 | MP0001730_embryonic_growth_arrest | 2.01337620 |
| 15 | MP0004808_abnormal_hematopoietic_stem | 1.92907933 |
| 16 | MP0000350_abnormal_cell_proliferation | 1.92069709 |
| 17 | MP0008995_early_reproductive_senescence | 1.85507611 |
| 18 | MP0002254_reproductive_system_inflammat | 1.84979081 |
| 19 | MP0001929_abnormal_gametogenesis | 1.76369744 |
| 20 | MP0001672_abnormal_embryogenesis/_devel | 1.75942527 |
| 21 | MP0005380_embryogenesis_phenotype | 1.75942527 |
| 22 | MP0000569_abnormal_digit_pigmentation | 1.75758679 |
| 23 | MP0004197_abnormal_fetal_growth/weight/ | 1.73674623 |
| 24 | MP0002084_abnormal_developmental_patter | 1.71410980 |
| 25 | MP0003763_abnormal_thymus_physiology | 1.71064777 |
| 26 | MP0003984_embryonic_growth_retardation | 1.69896353 |
| 27 | MP0002396_abnormal_hematopoietic_system | 1.68735029 |
| 28 | MP0002088_abnormal_embryonic_growth/wei | 1.68286848 |
| 29 | MP0003172_abnormal_lysosome_physiology | 1.67811953 |
| 30 | MP0006054_spinal_hemorrhage | 1.67757773 |
| 31 | MP0000537_abnormal_urethra_morphology | 1.67600923 |
| 32 | MP0003123_paternal_imprinting | 1.67407745 |
| 33 | MP0001697_abnormal_embryo_size | 1.61608623 |
| 34 | MP0002210_abnormal_sex_determination | 1.60330552 |
| 35 | MP0002085_abnormal_embryonic_tissue | 1.53962600 |
| 36 | MP0003890_abnormal_embryonic-extraembry | 1.51299416 |
| 37 | MP0002086_abnormal_extraembryonic_tissu | 1.51190183 |
| 38 | MP0002653_abnormal_ependyma_morphology | 1.50886947 |
| 39 | MP0003698_abnormal_male_reproductive | 1.48756374 |
| 40 | MP0008932_abnormal_embryonic_tissue | 1.48214974 |
| 41 | MP0001293_anophthalmia | 1.46319504 |
| 42 | MP0010234_abnormal_vibrissa_follicle | 1.45531958 |
| 43 | MP0005075_abnormal_melanosome_morpholog | 1.44005847 |
| 44 | MP0004185_abnormal_adipocyte_glucose | 1.43204554 |
| 45 | MP0003718_maternal_effect | 1.41000485 |
| 46 | MP0001873_stomach_inflammation | 1.40832462 |
| 47 | MP0003121_genomic_imprinting | 1.39437928 |
| 48 | MP0002877_abnormal_melanocyte_morpholog | 1.39416823 |
| 49 | MP0000703_abnormal_thymus_morphology | 1.38382581 |
| 50 | MP0001145_abnormal_male_reproductive | 1.36503007 |
| 51 | MP0002166_altered_tumor_susceptibility | 1.36066259 |
| 52 | MP0002080_prenatal_lethality | 1.35710843 |
| 53 | MP0001661_extended_life_span | 1.35200554 |
| 54 | MP0005220_abnormal_exocrine_pancreas | 1.34205832 |
| 55 | MP0009333_abnormal_splenocyte_physiolog | 1.33577321 |
| 56 | MP0009278_abnormal_bone_marrow | 1.32011592 |
| 57 | MP0003705_abnormal_hypodermis_morpholog | 1.31450252 |
| 58 | MP0001915_intracranial_hemorrhage | 1.30650886 |
| 59 | MP0010030_abnormal_orbit_morphology | 1.28208612 |
| 60 | MP0000015_abnormal_ear_pigmentation | 1.25628587 |
| 61 | MP0003787_abnormal_imprinting | 1.21959174 |
| 62 | MP0000733_abnormal_muscle_development | 1.21664493 |
| 63 | MP0003567_abnormal_fetal_cardiomyocyte | 1.18874739 |
| 64 | MP0009053_abnormal_anal_canal | 1.16386901 |
| 65 | MP0000465_gastrointestinal_hemorrhage | 1.16374105 |
| 66 | MP0000313_abnormal_cell_death | 1.14751525 |
| 67 | MP0002398_abnormal_bone_marrow | 1.14233819 |
| 68 | MP0002019_abnormal_tumor_incidence | 1.13523659 |
| 69 | MP0002006_tumorigenesis | 1.11854017 |
| 70 | MP0003436_decreased_susceptibility_to | 1.11090876 |
| 71 | MP0000428_abnormal_craniofacial_morphol | 1.10936671 |
| 72 | MP0004381_abnormal_hair_follicle | 1.09839849 |
| 73 | MP0003786_premature_aging | 1.09565735 |
| 74 | MP0000653_abnormal_sex_gland | 1.09250587 |
| 75 | MP0002282_abnormal_trachea_morphology | 1.07992403 |
| 76 | MP0000490_abnormal_crypts_of | 1.07856266 |
| 77 | MP0000678_abnormal_parathyroid_gland | 1.05088288 |
| 78 | MP0001800_abnormal_humoral_immune | 1.04513018 |
| 79 | MP0001348_abnormal_lacrimal_gland | 1.03982243 |
| 80 | MP0002697_abnormal_eye_size | 1.03565172 |
| 81 | MP0009703_decreased_birth_body | 1.02655771 |
| 82 | MP0003119_abnormal_digestive_system | 1.02024099 |
| 83 | MP0001545_abnormal_hematopoietic_system | 1.00926349 |
| 84 | MP0005397_hematopoietic_system_phenotyp | 1.00926349 |
| 85 | MP0003300_gastrointestinal_ulcer | 1.00507975 |
| 86 | MP0000685_abnormal_immune_system | 0.99992461 |
| 87 | MP0003115_abnormal_respiratory_system | 0.98712930 |
| 88 | MP0000003_abnormal_adipose_tissue | 0.98492222 |
| 89 | MP0005310_abnormal_salivary_gland | 0.98323905 |
| 90 | MP0003943_abnormal_hepatobiliary_system | 0.97119849 |
| 91 | MP0003566_abnormal_cell_adhesion | 0.96633140 |
| 92 | MP0002925_abnormal_cardiovascular_devel | 0.95887568 |
| 93 | MP0003283_abnormal_digestive_organ | 0.93640898 |
| 94 | MP0009672_abnormal_birth_weight | 0.93532841 |
| 95 | MP0003935_abnormal_craniofacial_develop | 0.92917301 |
| 96 | MP0005623_abnormal_meninges_morphology | 0.92308313 |
| 97 | MP0001243_abnormal_dermal_layer | 0.92225808 |
| 98 | MP0002722_abnormal_immune_system | 0.92214476 |
| 99 | MP0000432_abnormal_head_morphology | 0.90519091 |
| 100 | MP0002420_abnormal_adaptive_immunity | 0.89793544 |
| 101 | MP0000858_altered_metastatic_potential | 0.89254459 |
| 102 | MP0001119_abnormal_female_reproductive | 0.89195295 |
| 103 | MP0005647_abnormal_sex_gland | 0.89062978 |
| 104 | MP0003699_abnormal_female_reproductive | 0.88986720 |
| 105 | MP0001853_heart_inflammation | 0.88853854 |
| 106 | MP0002092_abnormal_eye_morphology | 0.87679002 |
| 107 | MP0002161_abnormal_fertility/fecundity | 0.87382207 |
| 108 | MP0001819_abnormal_immune_cell | 0.86439602 |
| 109 | MP0000371_diluted_coat_color | 0.84817087 |
| 110 | MP0001944_abnormal_pancreas_morphology | 0.84683932 |
| 111 | MP0005451_abnormal_body_composition | 0.84317886 |
| 112 | MP0008961_abnormal_basal_metabolism | 0.84135850 |
| 113 | MP0000689_abnormal_spleen_morphology | 0.83303896 |
| 114 | MP0002405_respiratory_system_inflammati | 0.81306603 |
| 115 | MP0005000_abnormal_immune_tolerance | 0.81302634 |
| 116 | MP0005023_abnormal_wound_healing | 0.81291745 |
| 117 | MP0000372_irregular_coat_pigmentation | 0.80905493 |
| 118 | MP0002009_preneoplasia | 0.80711845 |
| 119 | MP0003091_abnormal_cell_migration | 0.79633629 |
| 120 | MP0001849_ear_inflammation | 0.79152927 |
| 121 | MP0005671_abnormal_response_to | 0.78753150 |
| 122 | MP0005248_abnormal_Harderian_gland | 0.78522937 |
| 123 | MP0004264_abnormal_extraembryonic_tissu | 0.78413012 |
| 124 | MP0002970_abnormal_white_adipose | 0.78260477 |
| 125 | MP0003448_altered_tumor_morphology | 0.78245241 |
| 126 | MP0000613_abnormal_salivary_gland | 0.78021780 |
| 127 | MP0000516_abnormal_urinary_system | 0.77613733 |
| 128 | MP0005367_renal/urinary_system_phenotyp | 0.77613733 |
| 129 | MP0002160_abnormal_reproductive_system | 0.77460076 |
| 130 | MP0002138_abnormal_hepatobiliary_system | 0.74554578 |
| 131 | MP0002111_abnormal_tail_morphology | 0.73912271 |
| 132 | MP0002429_abnormal_blood_cell | 0.73765549 |
| 133 | MP0003861_abnormal_nervous_system | 0.73511866 |
| 134 | MP0003937_abnormal_limbs/digits/tail_de | 0.73401639 |
| 135 | MP0005670_abnormal_white_adipose | 0.72780468 |
| 136 | MP0005379_endocrine/exocrine_gland_phen | 0.72648743 |
| 137 | MP0003183_abnormal_peptide_metabolism | 0.72525306 |
| 138 | MP0005384_cellular_phenotype | 0.72476289 |
| 139 | MP0000716_abnormal_immune_system | 0.71949426 |
| 140 | MP0005621_abnormal_cell_physiology | 0.71654921 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Neoplasm of the adrenal cortex (HP:0100641) | 4.20490528 |
| 2 | Abnormality of the pancreatic islet cells (HP:0006476) | 3.61576591 |
| 3 | Abnormality of endocrine pancreas physiology (HP:0012093) | 3.61576591 |
| 4 | Nephroblastoma (Wilms tumor) (HP:0002667) | 3.41787222 |
| 5 | Pancreatic islet-cell hyperplasia (HP:0004510) | 3.30296155 |
| 6 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 3.30046321 |
| 7 | Short 4th metacarpal (HP:0010044) | 3.30046321 |
| 8 | Embryonal renal neoplasm (HP:0011794) | 3.24753758 |
| 9 | Degeneration of anterior horn cells (HP:0002398) | 2.90823958 |
| 10 | Abnormality of the anterior horn cell (HP:0006802) | 2.90823958 |
| 11 | Facial hemangioma (HP:0000329) | 2.88903172 |
| 12 | Panhypogammaglobulinemia (HP:0003139) | 2.87733782 |
| 13 | Hypoglycemic seizures (HP:0002173) | 2.85485059 |
| 14 | Basal cell carcinoma (HP:0002671) | 2.83755046 |
| 15 | Selective tooth agenesis (HP:0001592) | 2.82302985 |
| 16 | Hypoplastic labia majora (HP:0000059) | 2.80838270 |
| 17 | Severe combined immunodeficiency (HP:0004430) | 2.75593780 |
| 18 | Increased density of long bones (HP:0006392) | 2.65244717 |
| 19 | Abnormality of the lower motor neuron (HP:0002366) | 2.61861872 |
| 20 | Ependymoma (HP:0002888) | 2.60165789 |
| 21 | Volvulus (HP:0002580) | 2.58731922 |
| 22 | Abnormal hair whorl (HP:0010721) | 2.54764596 |
| 23 | High pitched voice (HP:0001620) | 2.49024653 |
| 24 | Abnormality of the labia majora (HP:0012881) | 2.48108093 |
| 25 | Abnormality of the preputium (HP:0100587) | 2.47309810 |
| 26 | Combined immunodeficiency (HP:0005387) | 2.45924607 |
| 27 | Abnormality of the fingertips (HP:0001211) | 2.45664534 |
| 28 | Deep palmar crease (HP:0006191) | 2.44662131 |
| 29 | 11 pairs of ribs (HP:0000878) | 2.44215786 |
| 30 | B lymphocytopenia (HP:0010976) | 2.43928426 |
| 31 | Microvesicular hepatic steatosis (HP:0001414) | 2.42798302 |
| 32 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.42782130 |
| 33 | Hypergonadotropic hypogonadism (HP:0000815) | 2.41548650 |
| 34 | Absent frontal sinuses (HP:0002688) | 2.40998572 |
| 35 | Ectopic kidney (HP:0000086) | 2.38305425 |
| 36 | T lymphocytopenia (HP:0005403) | 2.33816562 |
| 37 | Embryonal neoplasm (HP:0002898) | 2.33356652 |
| 38 | Severe visual impairment (HP:0001141) | 2.32916151 |
| 39 | Increased nuchal translucency (HP:0010880) | 2.30630767 |
| 40 | Abnormality of the metopic suture (HP:0005556) | 2.29895385 |
| 41 | Abnormality of DNA repair (HP:0003254) | 2.29193709 |
| 42 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.29106327 |
| 43 | Cutaneous melanoma (HP:0012056) | 2.29098539 |
| 44 | Symptomatic seizures (HP:0011145) | 2.27790081 |
| 45 | Medulloblastoma (HP:0002885) | 2.26810223 |
| 46 | Deviation of the thumb (HP:0009603) | 2.26396115 |
| 47 | Heterotopia (HP:0002282) | 2.25594568 |
| 48 | Urethral obstruction (HP:0000796) | 2.25189894 |
| 49 | Astrocytoma (HP:0009592) | 2.23243838 |
| 50 | Abnormality of the astrocytes (HP:0100707) | 2.23243838 |
| 51 | Long eyelashes (HP:0000527) | 2.22952696 |
| 52 | Chronic hepatic failure (HP:0100626) | 2.22750760 |
| 53 | Aqueductal stenosis (HP:0002410) | 2.22444121 |
| 54 | Amyotrophic lateral sclerosis (HP:0007354) | 2.22154934 |
| 55 | Proximal placement of thumb (HP:0009623) | 2.22140935 |
| 56 | Missing ribs (HP:0000921) | 2.22042959 |
| 57 | Abnormality of the 4th metacarpal (HP:0010012) | 2.20718001 |
| 58 | Chronic diarrhea (HP:0002028) | 2.20674402 |
| 59 | Abnormality of B cell number (HP:0010975) | 2.19566931 |
| 60 | Abnormality of the aortic arch (HP:0012303) | 2.14897470 |
| 61 | Nasal polyposis (HP:0100582) | 2.11804561 |
| 62 | Cafe-au-lait spot (HP:0000957) | 2.10227369 |
| 63 | Abnormality of the parathyroid morphology (HP:0011766) | 2.09833237 |
| 64 | Prominent nose (HP:0000448) | 2.09569762 |
| 65 | Broad face (HP:0000283) | 2.08468485 |
| 66 | Squamous cell carcinoma (HP:0002860) | 2.06641665 |
| 67 | Broad alveolar ridges (HP:0000187) | 2.06523869 |
| 68 | IgG deficiency (HP:0004315) | 2.06169795 |
| 69 | Tented upper lip vermilion (HP:0010804) | 2.05162231 |
| 70 | Unilateral renal agenesis (HP:0000122) | 2.05056245 |
| 71 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.04511971 |
| 72 | Trigonocephaly (HP:0000243) | 2.04485020 |
| 73 | Insulin resistance (HP:0000855) | 2.03450542 |
| 74 | Hepatoblastoma (HP:0002884) | 2.03345235 |
| 75 | Birth length less than 3rd percentile (HP:0003561) | 2.01893280 |
| 76 | Chromsome breakage (HP:0040012) | 2.01319440 |
| 77 | Intestinal atresia (HP:0011100) | 2.00011113 |
| 78 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.99444923 |
| 79 | Shallow orbits (HP:0000586) | 1.98761261 |
| 80 | Entropion (HP:0000621) | 1.97398788 |
| 81 | Hypoplasia of the thymus (HP:0000778) | 1.95778696 |
| 82 | Recurrent viral infections (HP:0004429) | 1.95666619 |
| 83 | Neoplasm of the adrenal gland (HP:0100631) | 1.95192520 |
| 84 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.95021431 |
| 85 | Abnormality of chromosome segregation (HP:0002916) | 1.94195313 |
| 86 | Hyperacusis (HP:0010780) | 1.93943054 |
| 87 | Agnosia (HP:0010524) | 1.92149343 |
| 88 | Colon cancer (HP:0003003) | 1.91938375 |
| 89 | Short 1st metacarpal (HP:0010034) | 1.91774395 |
| 90 | Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) | 1.91774395 |
| 91 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.91559864 |
| 92 | Chronic bronchitis (HP:0004469) | 1.91527205 |
| 93 | Bicuspid aortic valve (HP:0001647) | 1.88867446 |
| 94 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.88852846 |
| 95 | Absent/shortened dynein arms (HP:0200106) | 1.88852846 |
| 96 | Abnormality of T cell number (HP:0011839) | 1.88385596 |
| 97 | Abnormality of the labia minora (HP:0012880) | 1.88326251 |
| 98 | Abnormality of chromosome stability (HP:0003220) | 1.87874850 |
| 99 | Truncal obesity (HP:0001956) | 1.87713834 |
| 100 | Gastrointestinal carcinoma (HP:0002672) | 1.86217270 |
| 101 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.86217270 |
| 102 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.85817970 |
| 103 | Lymphopenia (HP:0001888) | 1.85343752 |
| 104 | Fatigue (HP:0012378) | 1.84787944 |
| 105 | Stomatitis (HP:0010280) | 1.84487477 |
| 106 | Abnormality of abdominal situs (HP:0011620) | 1.84264276 |
| 107 | Abdominal situs inversus (HP:0003363) | 1.84264276 |
| 108 | Progressive external ophthalmoplegia (HP:0000590) | 1.83806599 |
| 109 | Broad palm (HP:0001169) | 1.82970410 |
| 110 | Thyroiditis (HP:0100646) | 1.82511784 |
| 111 | Long palpebral fissure (HP:0000637) | 1.82445663 |
| 112 | Abnormality of T cells (HP:0002843) | 1.81343176 |
| 113 | Glioma (HP:0009733) | 1.81243377 |
| 114 | Impulsivity (HP:0100710) | 1.81021884 |
| 115 | Neoplasm of the oral cavity (HP:0100649) | 1.80660022 |
| 116 | Myelodysplasia (HP:0002863) | 1.80580837 |
| 117 | Abnormality of homocysteine metabolism (HP:0010919) | 1.80263002 |
| 118 | Homocystinuria (HP:0002156) | 1.80263002 |
| 119 | Premature ovarian failure (HP:0008209) | 1.79832678 |
| 120 | Broad phalanges of the hand (HP:0009768) | 1.79009511 |
| 121 | Long clavicles (HP:0000890) | 1.78990245 |
| 122 | Dislocated radial head (HP:0003083) | 1.78637702 |
| 123 | Supernumerary spleens (HP:0009799) | 1.78620897 |
| 124 | IgA deficiency (HP:0002720) | 1.78479231 |
| 125 | Bronchitis (HP:0012387) | 1.78362356 |
| 126 | Abnormality of the radial head (HP:0003995) | 1.77864709 |
| 127 | Small intestinal stenosis (HP:0012848) | 1.77655728 |
| 128 | Duodenal stenosis (HP:0100867) | 1.77655728 |
| 129 | Broad thumb (HP:0011304) | 1.77283295 |
| 130 | Renovascular hypertension (HP:0100817) | 1.76926625 |
| 131 | Gonadotropin excess (HP:0000837) | 1.76592132 |
| 132 | Renal duplication (HP:0000075) | 1.76482618 |
| 133 | Acute myeloid leukemia (HP:0004808) | 1.75583479 |
| 134 | Cutis marmorata (HP:0000965) | 1.73855641 |
| 135 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.73669229 |
| 136 | Abnormality of the nasal mucosa (HP:0000433) | 1.73640545 |
| 137 | Anal stenosis (HP:0002025) | 1.73061411 |
| 138 | Meckel diverticulum (HP:0002245) | 1.72828733 |
| 139 | Skull defect (HP:0001362) | 1.72725862 |
| 140 | IgM deficiency (HP:0002850) | 1.72455232 |
| 141 | Gastrointestinal inflammation (HP:0004386) | 1.71905106 |
| 142 | Rhabdomyosarcoma (HP:0002859) | 1.71865784 |
| 143 | Short humerus (HP:0005792) | 1.71440492 |
| 144 | Sensory axonal neuropathy (HP:0003390) | 1.71182876 |
| 145 | Short ribs (HP:0000773) | 1.70306989 |
| 146 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 1.69902532 |
| 147 | Recurrent bronchitis (HP:0002837) | 1.69585790 |
| 148 | Sloping forehead (HP:0000340) | 1.69539166 |
| 149 | Overlapping toe (HP:0001845) | 1.69507735 |
| 150 | Agammaglobulinemia (HP:0004432) | 1.69240374 |
| 151 | Atresia of the external auditory canal (HP:0000413) | 1.68883124 |
| 152 | Prominent metopic ridge (HP:0005487) | 1.68766590 |
| 153 | Abnormality of the carotid arteries (HP:0005344) | 1.68657436 |
| 154 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.67893204 |
| 155 | Tetany (HP:0001281) | 1.67537438 |
| 156 | Abnormality of the ileum (HP:0001549) | 1.67426944 |
| 157 | Abnormality of the duodenum (HP:0002246) | 1.65971352 |
| 158 | Upper motor neuron abnormality (HP:0002127) | 1.65047347 |
| 159 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.65003587 |
| 160 | Obsessive-compulsive behavior (HP:0000722) | 1.62281933 |
| 161 | Short phalanx of the thumb (HP:0009660) | 1.61585804 |
| 162 | Abnormal lung lobation (HP:0002101) | 1.61349827 |
| 163 | Narrow palate (HP:0000189) | 1.61200015 |
| 164 | Neoplasm of striated muscle (HP:0009728) | 1.60228721 |
| 165 | Amaurosis fugax (HP:0100576) | 1.58841326 |
| 166 | Spinal muscular atrophy (HP:0007269) | 1.58760480 |
| 167 | Cerebral aneurysm (HP:0004944) | 1.58583838 |
| 168 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.57849600 |
| 169 | Deep philtrum (HP:0002002) | 1.57353599 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 3.85691942 |
| 2 | CDC7 | 3.58856586 |
| 3 | PASK | 3.12143825 |
| 4 | TESK1 | 3.00551691 |
| 5 | SIK3 | 2.86127446 |
| 6 | EEF2K | 2.74154191 |
| 7 | SMG1 | 2.57822877 |
| 8 | MAP4K2 | 2.56795585 |
| 9 | SCYL2 | 2.49706970 |
| 10 | MAP3K10 | 2.44842719 |
| 11 | NEK2 | 2.40512549 |
| 12 | PDK4 | 2.28733479 |
| 13 | PDK3 | 2.28733479 |
| 14 | TAF1 | 2.16079721 |
| 15 | TRIM28 | 2.13931767 |
| 16 | FGFR2 | 2.08250810 |
| 17 | BRD4 | 2.02383249 |
| 18 | WEE1 | 1.99120938 |
| 19 | PRPF4B | 1.88763195 |
| 20 | PKN2 | 1.86602015 |
| 21 | TGFBR1 | 1.86122962 |
| 22 | DYRK3 | 1.75273910 |
| 23 | ATR | 1.63536397 |
| 24 | MST4 | 1.59916224 |
| 25 | SRPK1 | 1.55126331 |
| 26 | CDK7 | 1.54257316 |
| 27 | TESK2 | 1.53397232 |
| 28 | FLT3 | 1.52816238 |
| 29 | STK10 | 1.45672636 |
| 30 | MKNK1 | 1.42728994 |
| 31 | RPS6KA4 | 1.42034325 |
| 32 | TSSK6 | 1.37830802 |
| 33 | VRK2 | 1.35340587 |
| 34 | PDK2 | 1.31554218 |
| 35 | CHEK1 | 1.29213655 |
| 36 | PDGFRA | 1.26654588 |
| 37 | MAP4K1 | 1.19336851 |
| 38 | MKNK2 | 1.18509034 |
| 39 | RPS6KB2 | 1.17671946 |
| 40 | CDK4 | 1.16450585 |
| 41 | ICK | 1.15839191 |
| 42 | ATM | 1.14643810 |
| 43 | MTOR | 1.14032861 |
| 44 | PRKD3 | 1.13753908 |
| 45 | STK4 | 1.12929129 |
| 46 | PIM1 | 1.11985621 |
| 47 | BUB1 | 1.10850283 |
| 48 | TTK | 1.09531760 |
| 49 | PLK1 | 1.08920042 |
| 50 | TRIB3 | 1.08371848 |
| 51 | CDK9 | 1.06565281 |
| 52 | ACVR1B | 1.03570487 |
| 53 | CHEK2 | 1.03555341 |
| 54 | AURKB | 0.99714409 |
| 55 | NUAK1 | 0.99389068 |
| 56 | BRSK2 | 0.99014296 |
| 57 | CDK8 | 0.97984885 |
| 58 | STK3 | 0.97806886 |
| 59 | PLK3 | 0.97686284 |
| 60 | CAMK1D | 0.96977822 |
| 61 | CHUK | 0.96294969 |
| 62 | PAK4 | 0.96060745 |
| 63 | FRK | 0.94083593 |
| 64 | DYRK1B | 0.93010301 |
| 65 | MAP3K8 | 0.90796268 |
| 66 | HIPK2 | 0.88801145 |
| 67 | TLK1 | 0.88139260 |
| 68 | JAK3 | 0.87336942 |
| 69 | CLK1 | 0.85556538 |
| 70 | CDK2 | 0.85396521 |
| 71 | CDK6 | 0.84848430 |
| 72 | NEK1 | 0.84625613 |
| 73 | YES1 | 0.84571603 |
| 74 | TGFBR2 | 0.83715887 |
| 75 | VRK1 | 0.82421939 |
| 76 | MAP2K3 | 0.81004044 |
| 77 | FGFR3 | 0.80515180 |
| 78 | ZAP70 | 0.73096266 |
| 79 | PLK4 | 0.72614811 |
| 80 | LATS1 | 0.72462486 |
| 81 | STK38 | 0.72380412 |
| 82 | PLK2 | 0.71520212 |
| 83 | TTN | 0.70661430 |
| 84 | PRKD2 | 0.66953242 |
| 85 | AKT3 | 0.64907363 |
| 86 | EIF2AK3 | 0.64831850 |
| 87 | ITK | 0.64018375 |
| 88 | MAPK11 | 0.63392084 |
| 89 | TAOK2 | 0.63190284 |
| 90 | CSNK1G1 | 0.63062151 |
| 91 | ZAK | 0.62776380 |
| 92 | CDK1 | 0.61630621 |
| 93 | EIF2AK2 | 0.61183705 |
| 94 | PDGFRB | 0.59694066 |
| 95 | FGFR1 | 0.59018652 |
| 96 | STK38L | 0.59001715 |
| 97 | SIK2 | 0.58085595 |
| 98 | TNIK | 0.57435232 |
| 99 | MARK3 | 0.54622774 |
| 100 | ERBB3 | 0.54366469 |
| 101 | EPHA2 | 0.53857464 |
| 102 | CAMK1G | 0.53238574 |
| 103 | PAK2 | 0.52939834 |
| 104 | ERN1 | 0.52932460 |
| 105 | PTK6 | 0.52802673 |
| 106 | ALK | 0.52335726 |
| 107 | KSR1 | 0.51910336 |
| 108 | MELK | 0.51789048 |
| 109 | IRAK4 | 0.49227960 |
| 110 | CSF1R | 0.48689569 |
| 111 | BCR | 0.48539802 |
| 112 | RPS6KA5 | 0.47253135 |
| 113 | MAPK14 | 0.47213141 |
| 114 | RPS6KB1 | 0.46520415 |
| 115 | AKT1 | 0.46468962 |
| 116 | EIF2AK1 | 0.45654442 |
| 117 | MAP3K7 | 0.44296631 |
| 118 | LRRK2 | 0.43695261 |
| 119 | TXK | 0.42881603 |
| 120 | INSRR | 0.42688458 |
| 121 | FGFR4 | 0.42674102 |
| 122 | SIK1 | 0.42309420 |
| 123 | LCK | 0.42029540 |
| 124 | MAPK1 | 0.41880651 |
| 125 | CCNB1 | 0.41293436 |
| 126 | CSNK1D | 0.40749272 |
| 127 | AURKA | 0.40500380 |
| 128 | TYRO3 | 0.40374119 |
| 129 | GSK3B | 0.39894989 |
| 130 | RPS6KA1 | 0.39834824 |
| 131 | BMPR1B | 0.38274322 |
| 132 | PRKDC | 0.37867444 |
| 133 | NLK | 0.37633444 |
| 134 | NEK9 | 0.37615453 |
| 135 | MAPK8 | 0.36133750 |
| 136 | IKBKB | 0.34224404 |
| 137 | MAP3K3 | 0.33208084 |
| 138 | EPHA3 | 0.33113925 |
| 139 | CSNK1G3 | 0.32805061 |
| 140 | SGK3 | 0.32399164 |
| 141 | TAOK1 | 0.32119526 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 3.07081978 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 2.53275521 |
| 3 | RNA transport_Homo sapiens_hsa03013 | 2.42059382 |
| 4 | Spliceosome_Homo sapiens_hsa03040 | 2.39971313 |
| 5 | Cell cycle_Homo sapiens_hsa04110 | 2.39923402 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.27275736 |
| 7 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 2.15775149 |
| 8 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.13884757 |
| 9 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.04436876 |
| 10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.89575581 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 1.85343066 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 1.78655691 |
| 13 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.78263166 |
| 14 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.67164709 |
| 15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.64604581 |
| 16 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.64567504 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 1.60066782 |
| 18 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.59801964 |
| 19 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.54285394 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.53995400 |
| 21 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.38524335 |
| 22 | HTLV-I infection_Homo sapiens_hsa05166 | 1.36357117 |
| 23 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.35826560 |
| 24 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.35814784 |
| 25 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.31502099 |
| 26 | Basal transcription factors_Homo sapiens_hsa03022 | 1.31007076 |
| 27 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.30813427 |
| 28 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.30809306 |
| 29 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.26208560 |
| 30 | Colorectal cancer_Homo sapiens_hsa05210 | 1.25874779 |
| 31 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.25227509 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.24463354 |
| 33 | Circadian rhythm_Homo sapiens_hsa04710 | 1.22975388 |
| 34 | Alcoholism_Homo sapiens_hsa05034 | 1.22056728 |
| 35 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.19008049 |
| 36 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.17768551 |
| 37 | Legionellosis_Homo sapiens_hsa05134 | 1.16609458 |
| 38 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.15471701 |
| 39 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.14967288 |
| 40 | Adherens junction_Homo sapiens_hsa04520 | 1.14582876 |
| 41 | Measles_Homo sapiens_hsa05162 | 1.12879260 |
| 42 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.10276366 |
| 43 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.09716806 |
| 44 | Lysine degradation_Homo sapiens_hsa00310 | 1.08637407 |
| 45 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.08330510 |
| 46 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.07761969 |
| 47 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.04282069 |
| 48 | Hepatitis B_Homo sapiens_hsa05161 | 1.03781096 |
| 49 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.03056241 |
| 50 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.02492505 |
| 51 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.99750647 |
| 52 | Influenza A_Homo sapiens_hsa05164 | 0.96160612 |
| 53 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.95853692 |
| 54 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.95278383 |
| 55 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.94755138 |
| 56 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.93725106 |
| 57 | Shigellosis_Homo sapiens_hsa05131 | 0.92241551 |
| 58 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.92162881 |
| 59 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.91277953 |
| 60 | Other glycan degradation_Homo sapiens_hsa00511 | 0.90700999 |
| 61 | Viral myocarditis_Homo sapiens_hsa05416 | 0.90389872 |
| 62 | Endometrial cancer_Homo sapiens_hsa05213 | 0.89151036 |
| 63 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.87144070 |
| 64 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.86400169 |
| 65 | Proteasome_Homo sapiens_hsa03050 | 0.83889471 |
| 66 | Prostate cancer_Homo sapiens_hsa05215 | 0.83845483 |
| 67 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.83543228 |
| 68 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.81854815 |
| 69 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.81219672 |
| 70 | Thyroid cancer_Homo sapiens_hsa05216 | 0.81038369 |
| 71 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.80996506 |
| 72 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.79321622 |
| 73 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.79215383 |
| 74 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.79037345 |
| 75 | Apoptosis_Homo sapiens_hsa04210 | 0.77640556 |
| 76 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.77550116 |
| 77 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.75577831 |
| 78 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.75563564 |
| 79 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.75251854 |
| 80 | Leishmaniasis_Homo sapiens_hsa05140 | 0.74113993 |
| 81 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.73626972 |
| 82 | RNA polymerase_Homo sapiens_hsa03020 | 0.73027884 |
| 83 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.72672137 |
| 84 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.69936082 |
| 85 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.69102463 |
| 86 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.68705177 |
| 87 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.68018265 |
| 88 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.67619270 |
| 89 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.65191307 |
| 90 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.64168245 |
| 91 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.62633907 |
| 92 | Pathways in cancer_Homo sapiens_hsa05200 | 0.62480786 |
| 93 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.60904392 |
| 94 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.60872497 |
| 95 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.60577682 |
| 96 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.59631874 |
| 97 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.58900718 |
| 98 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.57221518 |
| 99 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.56327224 |
| 100 | Focal adhesion_Homo sapiens_hsa04510 | 0.54941575 |
| 101 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.54271837 |
| 102 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.54069434 |
| 103 | Salmonella infection_Homo sapiens_hsa05132 | 0.52573274 |
| 104 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.52165153 |
| 105 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.50558859 |
| 106 | Glioma_Homo sapiens_hsa05214 | 0.50102478 |
| 107 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.50005518 |
| 108 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.49804657 |
| 109 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.48855701 |
| 110 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.46909620 |
| 111 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.46813862 |
| 112 | Purine metabolism_Homo sapiens_hsa00230 | 0.46343258 |
| 113 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.45064572 |
| 114 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.45049787 |
| 115 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.44833713 |
| 116 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.44165214 |
| 117 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.43207984 |
| 118 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.41511317 |
| 119 | Bladder cancer_Homo sapiens_hsa05219 | 0.40356989 |
| 120 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.40286721 |
| 121 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.39397172 |
| 122 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.35876525 |
| 123 | Protein export_Homo sapiens_hsa03060 | 0.34682047 |
| 124 | Endocytosis_Homo sapiens_hsa04144 | 0.34060453 |
| 125 | Insulin resistance_Homo sapiens_hsa04931 | 0.32633718 |

