QRICH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.79881776
2cell wall macromolecule metabolic process (GO:0044036)9.57539543
3cell wall macromolecule catabolic process (GO:0016998)9.57539543
4motile cilium assembly (GO:0044458)9.32260494
5spermatid development (GO:0007286)9.29802670
6male meiosis (GO:0007140)9.07147766
7reproduction (GO:0000003)8.87484108
8cilium movement (GO:0003341)8.63410840
9regulation of cilium movement (GO:0003352)8.53590976
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.44422584
11synaptonemal complex organization (GO:0070193)8.30858811
12synaptonemal complex assembly (GO:0007130)7.84216722
13single fertilization (GO:0007338)7.35551497
14sperm capacitation (GO:0048240)6.99666996
15fertilization (GO:0009566)6.39784369
16DNA methylation involved in gamete generation (GO:0043046)6.37760554
17negative regulation of inclusion body assembly (GO:0090084)6.31694517
18male meiosis I (GO:0007141)6.27950823
19spermatogenesis (GO:0007283)6.01775602
20male gamete generation (GO:0048232)5.99603963
21ventricular system development (GO:0021591)5.79429731
22chromosome organization involved in meiosis (GO:0070192)5.51648275
23organic cation transport (GO:0015695)5.51178236
24gamete generation (GO:0007276)5.50671160
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.40368925
26germ cell development (GO:0007281)5.37205354
27meiotic nuclear division (GO:0007126)5.28791975
28regulation of inclusion body assembly (GO:0090083)5.13631365
29meiosis I (GO:0007127)5.08593876
30microtubule depolymerization (GO:0007019)5.07152816
31regulation of microtubule-based movement (GO:0060632)5.06079594
32seminiferous tubule development (GO:0072520)4.96216154
33microtubule severing (GO:0051013)4.84951405
34cell recognition (GO:0008037)4.81748255
35calcium ion-dependent exocytosis (GO:0017156)4.79696311
36urinary tract smooth muscle contraction (GO:0014848)4.70033945
37left/right pattern formation (GO:0060972)4.59670337
38response to pheromone (GO:0019236)4.58324662
39protein localization to cilium (GO:0061512)4.57584361
40meiotic cell cycle (GO:0051321)4.46993429
41multicellular organismal reproductive process (GO:0048609)4.33028548
42establishment of protein localization to Golgi (GO:0072600)4.27534854
43phosphatidylethanolamine biosynthetic process (GO:0006646)4.19798067
44monoubiquitinated protein deubiquitination (GO:0035520)4.12911566
45protein targeting to Golgi (GO:0000042)4.11248063
46genitalia morphogenesis (GO:0035112)4.08622660
47retrograde transport, vesicle recycling within Golgi (GO:0000301)4.07049377
48microtubule nucleation (GO:0007020)4.05811536
49protein polyglutamylation (GO:0018095)4.03815142
50intraciliary transport (GO:0042073)3.80780270
51phosphatidylethanolamine metabolic process (GO:0046337)3.78843678
52renal system development (GO:0072001)3.77596063
53gene silencing by RNA (GO:0031047)3.76032157
54spermatid nucleus differentiation (GO:0007289)3.66749247
55negative regulation of organelle assembly (GO:1902116)3.64646963
56positive regulation of Rab GTPase activity (GO:0032851)3.64373644
57regulation of Rab GTPase activity (GO:0032313)3.64373644
58chaperone-mediated protein complex assembly (GO:0051131)3.54681330
59positive regulation of action potential (GO:0045760)3.51337950
60multicellular organismal development (GO:0007275)3.50193567
61carnitine transport (GO:0015879)3.49538855
62amino-acid betaine transport (GO:0015838)3.49538855
63axoneme assembly (GO:0035082)3.47204550
64carnitine transmembrane transport (GO:1902603)3.46330540
65mitotic G1 DNA damage checkpoint (GO:0031571)3.44452165
66negative regulation of Rho protein signal transduction (GO:0035024)3.42175753
67microtubule-based movement (GO:0007018)3.41070519
68meiotic chromosome segregation (GO:0045132)3.37900740
69chromosome condensation (GO:0030261)3.37803046
70nuclear pore complex assembly (GO:0051292)3.36261594
71meiotic cell cycle process (GO:1903046)3.36240819
72synapsis (GO:0007129)3.35772116
73DNA packaging (GO:0006323)3.34963488
74cranial nerve morphogenesis (GO:0021602)3.33349185
75lactate metabolic process (GO:0006089)3.29696331
76glycerol ether metabolic process (GO:0006662)3.29137922
77mitotic G1/S transition checkpoint (GO:0044819)3.28395600
78regulation of ARF GTPase activity (GO:0032312)3.27557109
79regulation of centriole replication (GO:0046599)3.27024359
80histone H4 deacetylation (GO:0070933)3.22959709
81protein refolding (GO:0042026)3.21608589
82protein localization to Golgi apparatus (GO:0034067)3.19793033
83chromatin silencing (GO:0006342)3.18988831
84peptidyl-threonine dephosphorylation (GO:0035970)3.18437250
85cilium organization (GO:0044782)3.17266812
86regulation of spindle checkpoint (GO:0090231)3.15042237
87regulation of meiosis I (GO:0060631)3.11099254
88regulation of somitogenesis (GO:0014807)3.08767593
89histone H3 deacetylation (GO:0070932)3.06859205
90cell migration in hindbrain (GO:0021535)3.06178367
91histone H3-K9 demethylation (GO:0033169)3.03962236
92ether metabolic process (GO:0018904)3.03485644
93cilium assembly (GO:0042384)2.98643753
94tachykinin receptor signaling pathway (GO:0007217)2.95530088
95single strand break repair (GO:0000012)2.95496463
96rRNA methylation (GO:0031167)2.91843609
97G1 DNA damage checkpoint (GO:0044783)2.88835774
98cellular component assembly involved in morphogenesis (GO:0010927)2.88072754
99regulation of protein polyubiquitination (GO:1902914)2.87112351
100positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.87028380
101cilium morphogenesis (GO:0060271)2.87010944
102nucleus organization (GO:0006997)2.85397090
103mitotic sister chromatid cohesion (GO:0007064)2.83909413
104peptidyl-glutamic acid modification (GO:0018200)2.82303018
105alditol metabolic process (GO:0019400)2.80709188
106histone H3-K9 methylation (GO:0051567)2.79515054
107glycolytic process (GO:0006096)2.75982257
108centrosome duplication (GO:0051298)2.75164292
109polyol catabolic process (GO:0046174)2.73958237
110RNA destabilization (GO:0050779)2.72409810
111centriole replication (GO:0007099)2.72288382
112nucleoside diphosphate phosphorylation (GO:0006165)2.70328637
113positive regulation of protein kinase C signaling (GO:0090037)2.70320870
114gene silencing (GO:0016458)2.69950706
115negative regulation of DNA repair (GO:0045738)2.68435864
116regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.68148299
117histone lysine methylation (GO:0034968)2.66549372
118protein-DNA complex disassembly (GO:0032986)2.66248103
119nucleosome disassembly (GO:0006337)2.66248103
120centriole assembly (GO:0098534)2.64707723
121pore complex assembly (GO:0046931)2.60910073
122nuclear pore organization (GO:0006999)2.60765053
123RNA localization (GO:0006403)2.59056728
124ionotropic glutamate receptor signaling pathway (GO:0035235)2.57861944
125insulin-like growth factor receptor signaling pathway (GO:0048009)2.56567231
126microtubule polymerization or depolymerization (GO:0031109)2.55982272
127G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.55708612
128musculoskeletal movement (GO:0050881)2.54515126
129multicellular organismal movement (GO:0050879)2.54515126
130urogenital system development (GO:0001655)2.53669164
131negative regulation of gene expression, epigenetic (GO:0045814)2.53231069
132protein K11-linked deubiquitination (GO:0035871)2.51436774
133negative regulation of skeletal muscle tissue development (GO:0048642)2.50675748
134neurotransmitter-gated ion channel clustering (GO:0072578)2.48948189
135cerebral cortex neuron differentiation (GO:0021895)2.48923392
136nephron tubule morphogenesis (GO:0072078)2.48154497
137nephron epithelium morphogenesis (GO:0072088)2.48154497
138negative regulation of translation, ncRNA-mediated (GO:0040033)2.47129787
139regulation of translation, ncRNA-mediated (GO:0045974)2.47129787
140negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.47129787
141sex differentiation (GO:0007548)2.46499466
142protein localization to synapse (GO:0035418)2.45724423
143camera-type eye morphogenesis (GO:0048593)2.44628277
144cellular ketone body metabolic process (GO:0046950)2.43697638
145membrane depolarization during action potential (GO:0086010)2.43620352
146histone H3-K9 modification (GO:0061647)2.43205963
147cilium or flagellum-dependent cell motility (GO:0001539)14.9433070
148fusion of sperm to egg plasma membrane (GO:0007342)13.1555286
149sperm motility (GO:0030317)12.4037291
150sperm-egg recognition (GO:0035036)11.1741711
151axonemal dynein complex assembly (GO:0070286)10.9018569
152acrosome assembly (GO:0001675)10.8478014
153multicellular organism reproduction (GO:0032504)10.8432120
154acrosome reaction (GO:0007340)10.7747444
155binding of sperm to zona pellucida (GO:0007339)10.2046619
156piRNA metabolic process (GO:0034587)10.0525989
157plasma membrane fusion (GO:0045026)10.0132921
158cell-cell recognition (GO:0009988)10.0039061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.49258807
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.68824720
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.50397014
4DROSHA_22980978_ChIP-Seq_HELA_Human3.16086052
5* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.95472619
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.64233660
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.56099861
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34378523
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.34363450
10CTCF_27219007_Chip-Seq_Bcells_Human2.25628238
11P68_20966046_ChIP-Seq_HELA_Human2.17618359
12ZNF274_21170338_ChIP-Seq_K562_Hela2.11052909
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04855550
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04803106
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04439141
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.3149750
17SMC4_20622854_ChIP-Seq_HELA_Human1.98677986
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97209313
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.97057865
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.96654016
21GATA1_26923725_Chip-Seq_HPCs_Mouse1.96532837
22LXR_22292898_ChIP-Seq_THP-1_Human1.95394945
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.87979618
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.86680822
25VDR_22108803_ChIP-Seq_LS180_Human1.84184913
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80179974
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79311593
28ERA_21632823_ChIP-Seq_H3396_Human1.69284738
29KDM2B_26808549_Chip-Seq_K562_Human1.67120609
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65456657
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.63286852
32E2F1_20622854_ChIP-Seq_HELA_Human1.61499347
33BCOR_27268052_Chip-Seq_Bcells_Human1.60097052
34MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.59501977
35AR_21572438_ChIP-Seq_LNCaP_Human1.58955288
36PHF8_20622854_ChIP-Seq_HELA_Human1.55993438
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.55893894
38STAT1_17558387_ChIP-Seq_HELA_Human1.54058763
39* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53909156
40CBP_20019798_ChIP-Seq_JUKART_Human1.51907369
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51907369
42KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.51639331
43BCL6_27268052_Chip-Seq_Bcells_Human1.51379386
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.48327500
45GBX2_23144817_ChIP-Seq_PC3_Human1.46689663
46RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46004212
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45333106
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44047186
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43922701
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.42308209
51KDM2B_26808549_Chip-Seq_DND41_Human1.38931755
52* OCT4_19829295_ChIP-Seq_ESCs_Human1.38767997
53RAC3_21632823_ChIP-Seq_H3396_Human1.38160681
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37791396
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37610070
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37370599
57TP63_22573176_ChIP-Seq_HFKS_Human1.36226099
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.35863272
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35838857
60TCF7_22412390_ChIP-Seq_EML_Mouse1.33816864
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33703677
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.33255285
63KAP1_22055183_ChIP-Seq_ESCs_Mouse1.33183654
64SOX2_22085726_ChIP-Seq_NPCs_Mouse1.32832716
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.31520767
66GATA3_21867929_ChIP-Seq_CD8_Mouse1.31293081
67TDRD3_21172665_ChIP-Seq_MCF-7_Human1.30739174
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29355756
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29101304
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.28957638
71CTCF_20526341_ChIP-Seq_ESCs_Human1.28771363
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.28220107
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26655045
74TP53_22127205_ChIP-Seq_IMR90_Human1.24539878
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24499656
76KDM2B_26808549_Chip-Seq_REH_Human1.24218758
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.23107633
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.21827144
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21104156
80TP53_23651856_ChIP-Seq_MEFs_Mouse1.20827757
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20497117
82CREB1_26743006_Chip-Seq_LNCaP_Human1.20428248
83TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18894119
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18706657
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18702756
86SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.18549018
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18363477
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.18321761
89FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18260060
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.18170812
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.17617977
92REST_21632747_ChIP-Seq_MESCs_Mouse1.17340843
93RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17247816
94EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17247816
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.17224147
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16213378
97OCT4_20526341_ChIP-Seq_ESCs_Human1.16071050
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15927926
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15629474
100JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15405715
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14028897
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.13655950
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.13343651
104* SA1_27219007_Chip-Seq_Bcells_Human1.13230358
105RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13120791
106PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12545992
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12230799
108* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11941101
109CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11896322
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11654315
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10484652
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10468094
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10050062
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10050062
115GATA3_21867929_ChIP-Seq_TH1_Mouse1.09454257
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09281889
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08958221
118MAF_26560356_Chip-Seq_TH2_Human1.08750784
119TET1_21490601_ChIP-Seq_MESCs_Mouse1.08467290
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07231580
121* P53_21459846_ChIP-Seq_SAOS-2_Human1.06956391
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.06730445
123KDM2B_26808549_Chip-Seq_JURKAT_Human1.06434428
124RUNX1_27514584_Chip-Seq_MCF-7_Human1.06096456
125GF1_26923725_Chip-Seq_HPCs_Mouse1.05524185
126MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05086615
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04416281
128* MYC_19829295_ChIP-Seq_ESCs_Human1.04221133
129EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03033395
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02903079
131* KLF4_19829295_ChIP-Seq_ESCs_Human1.02312064
132NANOG_18555785_Chip-Seq_ESCs_Mouse1.01698643
133CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01423946
134OCT4_18555785_Chip-Seq_ESCs_Mouse1.01280159
135CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01193769
136SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00980996
137ERG_20517297_ChIP-Seq_VCAP_Human1.00590465
138* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00014041
139* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.97939846
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.97442410
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96752053
142RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96597255
143OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96145246
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95375492
145YY1_22570637_ChIP-Seq_MALME-3M_Human0.94947660
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94651407
147EZH2_27294783_Chip-Seq_NPCs_Mouse0.94225650
148P53_22387025_ChIP-Seq_ESCs_Mouse0.93313663
149ESET_19884257_ChIP-Seq_ESCs_Mouse0.92020514
150RARA_24833708_ChIP-Seq_LIVER_Mouse0.91832747
151KLF4_18555785_Chip-Seq_ESCs_Mouse0.91450438
152RNF2_27304074_Chip-Seq_NSC_Mouse0.91325496
153SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90970566
154P300_18555785_Chip-Seq_ESCs_Mouse0.90684157
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90409375
156CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90119774
157ESRRB_18555785_Chip-Seq_ESCs_Mouse0.90038690
158EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89770394
159PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89620840
160MYC_27129775_Chip-Seq_CORNEA_Mouse0.89301142
161* SPI1_26923725_Chip-Seq_HPCs_Mouse0.88541536
162RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88288018
163RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87940668
164ELF1_20517297_ChIP-Seq_JURKAT_Human0.87137136
165MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86746020
166TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85413056
167PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85153342
168STAT3_18555785_Chip-Seq_ESCs_Mouse0.84970590
169CMYC_18555785_Chip-Seq_ESCs_Mouse0.84295297
170EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84061203
171FLI1_21867929_ChIP-Seq_CD8_Mouse0.83214676
172LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82651734
173* SOX2_21211035_ChIP-Seq_LN229_Human0.82520280
174TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81482009
175TCF4_23295773_ChIP-Seq_U87_Human0.81476763
176SMAD4_21741376_ChIP-Seq_EPCs_Human0.80584708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.99447107
2MP0001929_abnormal_gametogenesis5.48419408
3MP0008877_abnormal_DNA_methylation5.12367980
4MP0002210_abnormal_sex_determination3.74427620
5MP0002653_abnormal_ependyma_morphology3.41340233
6MP0005423_abnormal_somatic_nervous3.24855010
7MP0002161_abnormal_fertility/fecundity3.24542688
8MP0001145_abnormal_male_reproductive3.17187094
9MP0000566_synostosis2.97257840
10MP0000653_abnormal_sex_gland2.74621607
11MP0001968_abnormal_touch/_nociception2.41818286
12MP0005409_darkened_coat_color2.41483251
13MP0002735_abnormal_chemical_nociception2.37470463
14MP0001986_abnormal_taste_sensitivity2.34202959
15MP0005623_abnormal_meninges_morphology2.32834913
16MP0004859_abnormal_synaptic_plasticity2.24901481
17MP0002160_abnormal_reproductive_system2.06887421
18MP0005670_abnormal_white_adipose2.01930937
19MP0005410_abnormal_fertilization15.4655126
20MP0001348_abnormal_lacrimal_gland1.92927228
21MP0002249_abnormal_larynx_morphology1.83575452
22MP0006276_abnormal_autonomic_nervous1.78700698
23MP0003646_muscle_fatigue1.77637110
24MP0003635_abnormal_synaptic_transmissio1.70197527
25MP0001486_abnormal_startle_reflex1.66916756
26MP0000955_abnormal_spinal_cord1.66779074
27MP0000778_abnormal_nervous_system1.64341356
28MP0002063_abnormal_learning/memory/cond1.63404312
29MP0002736_abnormal_nociception_after1.60121542
30MP0005499_abnormal_olfactory_system1.59334379
31MP0005394_taste/olfaction_phenotype1.59334379
32MP0002572_abnormal_emotion/affect_behav1.56601330
33MP0004742_abnormal_vestibular_system1.54334687
34MP0008057_abnormal_DNA_replication1.54088792
35MP0002282_abnormal_trachea_morphology1.44330520
36MP0000003_abnormal_adipose_tissue1.43524925
37MP0003172_abnormal_lysosome_physiology1.43002724
38MP0008789_abnormal_olfactory_epithelium1.35957470
39MP0000013_abnormal_adipose_tissue1.33519850
40MP0001188_hyperpigmentation1.32738005
41MP0002184_abnormal_innervation1.29505082
42MP0002822_catalepsy1.28465311
43MP0002067_abnormal_sensory_capabilities1.27019197
44MP0009046_muscle_twitch1.26826059
45MP0001529_abnormal_vocalization1.23840822
46MP0004233_abnormal_muscle_weight1.20124591
47MP0005310_abnormal_salivary_gland1.19800713
48MP0003183_abnormal_peptide_metabolism1.19265190
49MP0005171_absent_coat_pigmentation1.16581207
50MP0008058_abnormal_DNA_repair1.14852517
51MP0009745_abnormal_behavioral_response1.12750709
52MP0002882_abnormal_neuron_morphology1.12406777
53MP0005647_abnormal_sex_gland1.11926415
54MP0003136_yellow_coat_color1.11829376
55MP0008872_abnormal_physiological_respon1.09631197
56MP0000026_abnormal_inner_ear1.07566100
57MP0002734_abnormal_mechanical_nocicepti1.07549948
58MP0004270_analgesia1.06801427
59MP0002272_abnormal_nervous_system1.06728789
60MP0010094_abnormal_chromosome_stability1.05927311
61MP0006292_abnormal_olfactory_placode1.05846337
62MP0001502_abnormal_circadian_rhythm1.04988876
63MP0005389_reproductive_system_phenotype1.04711102
64MP0000678_abnormal_parathyroid_gland1.04069956
65MP0002064_seizures0.99773892
66MP0001984_abnormal_olfaction0.99449926
67MP0001970_abnormal_pain_threshold0.98995854
68MP0008995_early_reproductive_senescence0.97705610
69MP0001270_distended_abdomen0.97551747
70MP0009053_abnormal_anal_canal0.97459987
71MP0001299_abnormal_eye_distance/0.97069032
72MP0001765_abnormal_ion_homeostasis0.96993597
73MP0000579_abnormal_nail_morphology0.95772019
74MP0002557_abnormal_social/conspecific_i0.92488331
75MP0005076_abnormal_cell_differentiation0.89759474
76MP0005167_abnormal_blood-brain_barrier0.89307242
77MP0005360_urolithiasis0.87931423
78MP0003011_delayed_dark_adaptation0.81809228
79MP0000383_abnormal_hair_follicle0.81658796
80MP0002752_abnormal_somatic_nervous0.81631973
81MP0008007_abnormal_cellular_replicative0.80951674
82MP0005257_abnormal_intraocular_pressure0.80009005
83MP0003878_abnormal_ear_physiology0.79700595
84MP0005377_hearing/vestibular/ear_phenot0.79700595
85MP0004381_abnormal_hair_follicle0.78152748
86MP0004858_abnormal_nervous_system0.77611016
87MP0000569_abnormal_digit_pigmentation0.76142659
88MP0003786_premature_aging0.75834600
89MP0003950_abnormal_plasma_membrane0.75030959
90MP0005386_behavior/neurological_phenoty0.74936304
91MP0004924_abnormal_behavior0.74936304
92MP0008770_decreased_survivor_rate0.73013981
93MP0003385_abnormal_body_wall0.71807904
94MP0002932_abnormal_joint_morphology0.71753215
95MP0000358_abnormal_cell_content/0.69452715
96MP0003115_abnormal_respiratory_system0.69362639
97MP0001963_abnormal_hearing_physiology0.68861757
98MP0001501_abnormal_sleep_pattern0.68783882
99MP0003119_abnormal_digestive_system0.66834033
100MP0004142_abnormal_muscle_tone0.65634769
101MP0009278_abnormal_bone_marrow0.62602552
102MP0001545_abnormal_hematopoietic_system0.61702726
103MP0005397_hematopoietic_system_phenotyp0.61702726
104MP0003111_abnormal_nucleus_morphology0.54862561
105MP0003699_abnormal_female_reproductive0.52990412
106MP0001293_anophthalmia0.50809334
107MP0002928_abnormal_bile_duct0.50671427
108MP0004808_abnormal_hematopoietic_stem0.48550023
109MP0005666_abnormal_adipose_tissue0.48493389
110MP0005636_abnormal_mineral_homeostasis0.46784219
111MP0003329_amyloid_beta_deposits0.46412591
112MP0004134_abnormal_chest_morphology0.45422857
113MP0004036_abnormal_muscle_relaxation0.42307246
114MP0010307_abnormal_tumor_latency0.42273641
115MP0001324_abnormal_eye_pigmentation0.41105024
116MP0001730_embryonic_growth_arrest0.39822274
117MP0002234_abnormal_pharynx_morphology0.39279319
118MP0001119_abnormal_female_reproductive0.38398558
119MP0002269_muscular_atrophy0.37841549
120MP0001661_extended_life_span0.36282430
121MP0006036_abnormal_mitochondrial_physio0.35600071
122MP0002971_abnormal_brown_adipose0.34407879
123MP0005253_abnormal_eye_physiology0.34367160
124MP0005391_vision/eye_phenotype0.33979997
125MP0001727_abnormal_embryo_implantation0.33688266
126MP0001764_abnormal_homeostasis0.31546061
127MP0009115_abnormal_fat_cell0.31527234
128MP0005551_abnormal_eye_electrophysiolog0.31454729
129MP0008961_abnormal_basal_metabolism0.31343650
130MP0000751_myopathy0.30846252
131MP0003879_abnormal_hair_cell0.30662768
132MP0000313_abnormal_cell_death0.29365553
133MP0003861_abnormal_nervous_system0.28490076
134MP0004811_abnormal_neuron_physiology0.27378153
135MP0003045_fibrosis0.27310178
136MP0003077_abnormal_cell_cycle0.26036223
137MP0002092_abnormal_eye_morphology0.25871332
138MP0002152_abnormal_brain_morphology0.25631322
139MP0004019_abnormal_vitamin_homeostasis0.25285571
140MP0002084_abnormal_developmental_patter0.25266459
141MP0003633_abnormal_nervous_system0.24980104
142MP0004133_heterotaxia0.23353128
143MP0000534_abnormal_ureter_morphology0.23023664
144MP0006035_abnormal_mitochondrial_morpho0.22493011
145MP0000427_abnormal_hair_cycle0.21685694
146MP0003942_abnormal_urinary_system0.21290793
147MP0003631_nervous_system_phenotype0.20324169
148MP0000604_amyloidosis0.19903637
149MP0001851_eye_inflammation0.18587114
150MP0003787_abnormal_imprinting0.18293103
151MP0002102_abnormal_ear_morphology0.18147398
152MP0002108_abnormal_muscle_morphology0.18103747
153MP0001697_abnormal_embryo_size0.17369537
154MP0005380_embryogenesis_phenotype0.17326335
155MP0001672_abnormal_embryogenesis/_devel0.17326335
156MP0003948_abnormal_gas_homeostasis0.17150327
157MP0002295_abnormal_pulmonary_circulatio0.16754813
158MP0003936_abnormal_reproductive_system0.16196940
159MP0002405_respiratory_system_inflammati0.15705964
160MP0002796_impaired_skin_barrier0.15171121
161MP0002229_neurodegeneration0.15167668
162MP0005375_adipose_tissue_phenotype0.14231346
163MP0002169_no_abnormal_phenotype0.13854402
164MP0002873_normal_phenotype0.13603195
165MP0002970_abnormal_white_adipose0.13188105
166MP0003959_abnormal_lean_body0.12615020
167MP0004130_abnormal_muscle_cell0.12005228

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.18832760
2Abnormal respiratory motile cilium morphology (HP:0005938)8.62050850
3Abnormal respiratory epithelium morphology (HP:0012253)8.62050850
4Rhinitis (HP:0012384)7.94666256
5Abnormal ciliary motility (HP:0012262)7.28219851
6Chronic bronchitis (HP:0004469)7.05583450
7Nasal polyposis (HP:0100582)6.52055153
8Infertility (HP:0000789)6.40360744
9Abnormality of the nasal mucosa (HP:0000433)5.35942334
10Nephronophthisis (HP:0000090)4.84917561
11Bronchiectasis (HP:0002110)4.67366621
12Bronchitis (HP:0012387)4.61049915
13Progressive cerebellar ataxia (HP:0002073)4.32280235
14Abnormality of the aortic arch (HP:0012303)3.82512233
15Abnormality of the lower motor neuron (HP:0002366)3.80069678
16Male infertility (HP:0003251)3.78761172
17Chronic hepatic failure (HP:0100626)3.74740713
18Abnormality of the renal medulla (HP:0100957)3.69091192
19Bony spicule pigmentary retinopathy (HP:0007737)3.65037489
20Attenuation of retinal blood vessels (HP:0007843)3.40036749
21Recurrent otitis media (HP:0000403)3.38685321
22Abnormality of the labia minora (HP:0012880)3.29487860
23Abnormal spermatogenesis (HP:0008669)3.25131314
24Recurrent sinusitis (HP:0011108)3.19141655
25Genetic anticipation (HP:0003743)3.11373172
26Rib fusion (HP:0000902)3.05837088
27Facial hemangioma (HP:0000329)3.05747002
28Tubulointerstitial nephritis (HP:0001970)3.04573243
29Gonadotropin excess (HP:0000837)2.99646425
30Recurrent bronchitis (HP:0002837)2.98027557
31Amyotrophic lateral sclerosis (HP:0007354)2.93055655
32Hyperkalemia (HP:0002153)2.89759475
33Tubular atrophy (HP:0000092)2.89079218
34Abnormality of cochlea (HP:0000375)2.79355283
35Abnormality of midbrain morphology (HP:0002418)2.75682561
36Molar tooth sign on MRI (HP:0002419)2.75682561
37Tubulointerstitial abnormality (HP:0001969)2.70384269
38Back pain (HP:0003418)2.70035276
39Severe visual impairment (HP:0001141)2.65887473
40Renovascular hypertension (HP:0100817)2.63937618
41Impulsivity (HP:0100710)2.56970365
42Shawl scrotum (HP:0000049)2.50711445
43Abnormal rod and cone electroretinograms (HP:0008323)2.50188951
44Fibular hypoplasia (HP:0003038)2.48836493
45Medial flaring of the eyebrow (HP:0010747)2.45123514
46Epileptic encephalopathy (HP:0200134)2.42516709
47Azoospermia (HP:0000027)2.40987565
48Impaired proprioception (HP:0010831)2.32158799
49Febrile seizures (HP:0002373)2.31622058
50Thin bony cortex (HP:0002753)2.28516402
51Tubulointerstitial fibrosis (HP:0005576)2.25370609
52Turricephaly (HP:0000262)2.25032416
53Thin ribs (HP:0000883)2.24523438
54Asymmetric septal hypertrophy (HP:0001670)2.22693925
55Postaxial foot polydactyly (HP:0001830)2.20629103
56Patellar aplasia (HP:0006443)2.20538938
57Morphological abnormality of the inner ear (HP:0011390)2.20526033
58Aplasia/Hypoplasia of the sternum (HP:0006714)2.18204970
59Broad face (HP:0000283)2.16165947
60Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15800745
61Ulnar bowing (HP:0003031)2.15688982
62Natal tooth (HP:0000695)2.15338820
63Upper motor neuron abnormality (HP:0002127)2.15057578
64Abnormality of the astrocytes (HP:0100707)2.14910688
65Astrocytoma (HP:0009592)2.14910688
66Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.14319504
67Hypoplastic ischia (HP:0003175)2.13875694
68Stage 5 chronic kidney disease (HP:0003774)2.09056051
69Hypoplasia of the brainstem (HP:0002365)2.06905671
70Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06905671
71Ependymoma (HP:0002888)2.05766861
72Abnormality of the parathyroid morphology (HP:0011766)2.05294905
73Obstructive sleep apnea (HP:0002870)2.04961763
74Abnormality of the anterior horn cell (HP:0006802)2.04185387
75Degeneration of anterior horn cells (HP:0002398)2.04185387
76Abnormality of the ischium (HP:0003174)2.03838856
77Hand muscle atrophy (HP:0009130)2.03053194
78Abnormal drinking behavior (HP:0030082)2.02900616
79Polydipsia (HP:0001959)2.02900616
80Breast hypoplasia (HP:0003187)2.02499390
81Focal seizures (HP:0007359)2.01790930
82Congenital hepatic fibrosis (HP:0002612)2.01269124
83Cutaneous finger syndactyly (HP:0010554)2.01153607
84Short ribs (HP:0000773)2.00929254
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5035379
86Absent/shortened dynein arms (HP:0200106)12.3164695
87Dynein arm defect of respiratory motile cilia (HP:0012255)12.3164695
88Abnormality of the renal cortex (HP:0011035)1.96841116
89Absent frontal sinuses (HP:0002688)1.95666944
90Aplasia/Hypoplasia of the patella (HP:0006498)1.94467937
91Neoplasm of the heart (HP:0100544)1.93466034
92Abnormal gallbladder physiology (HP:0012438)1.93430643
93Cholecystitis (HP:0001082)1.93430643
94Vitreoretinal degeneration (HP:0000655)1.93229846
95Atrophic scars (HP:0001075)1.92502833
96Flattened epiphyses (HP:0003071)1.92241602
97Oculomotor apraxia (HP:0000657)1.90879440
98Aplasia/Hypoplasia of the earlobes (HP:0009906)1.89043610
99Birth length less than 3rd percentile (HP:0003561)1.87917748
100J-shaped sella turcica (HP:0002680)1.87700766
101Microglossia (HP:0000171)1.86054717
102Amblyopia (HP:0000646)1.85734214
103Polycystic kidney dysplasia (HP:0000113)1.84820975
104Upper limb amyotrophy (HP:0009129)1.84791596
105Distal upper limb amyotrophy (HP:0007149)1.84791596
106Cutaneous syndactyly (HP:0012725)1.83663942
107Renal dysplasia (HP:0000110)1.83194344
108Spastic tetraparesis (HP:0001285)1.82374264
109Hyperacusis (HP:0010780)1.82085526
110Tracheomalacia (HP:0002779)1.80836075
111Intestinal fistula (HP:0100819)1.80229508
112Short palpebral fissure (HP:0012745)1.79352180
113Abnormality of dentin (HP:0010299)1.78892613
114Shallow orbits (HP:0000586)1.78847230
115Heterotopia (HP:0002282)1.77660507
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76425128
117Esophageal atresia (HP:0002032)1.76303380
118Ankle clonus (HP:0011448)1.76072985
119Acute lymphatic leukemia (HP:0006721)1.74609720
120Occipital encephalocele (HP:0002085)1.73256595
121Bilateral sensorineural hearing impairment (HP:0008619)1.71918361
122Capillary hemangiomas (HP:0005306)1.71234119
123Bell-shaped thorax (HP:0001591)1.70567984
124Absent epiphyses (HP:0010577)1.70246286
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70246286
126Abnormality of permanent molar morphology (HP:0011071)1.69066117
127Abnormality of the dental root (HP:0006486)1.69066117
128Taurodontia (HP:0000679)1.69066117
129Truncal obesity (HP:0001956)1.69041203
130Supernumerary ribs (HP:0005815)1.68899785
131Atonic seizures (HP:0010819)1.68304851
132Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67850473
133Atelectasis (HP:0100750)1.66276665
134Supernumerary bones of the axial skeleton (HP:0009144)1.65387934
135Facial cleft (HP:0002006)1.64194914
136Bulbous nose (HP:0000414)1.63929127
137Abnormality of renal excretion (HP:0011036)1.63612152
138Intellectual disability, moderate (HP:0002342)1.63481766
139Self-mutilation (HP:0000742)1.63268770
140Bowel incontinence (HP:0002607)1.62949044
141Neonatal short-limb short stature (HP:0008921)1.62511442
142Postaxial hand polydactyly (HP:0001162)1.61311851
143Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.61020148
144Short 4th metacarpal (HP:0010044)1.61020148
145Chronic sinusitis (HP:0011109)1.60947446
146Stereotypic behavior (HP:0000733)1.60817891
147Bronchomalacia (HP:0002780)1.60801177
148Severe Myopia (HP:0011003)1.59869571
149Chromsome breakage (HP:0040012)1.59241518
150Abnormality of the hepatic vasculature (HP:0006707)1.59043444
151Abnormality of molar (HP:0011077)1.58337161
152Abnormality of molar morphology (HP:0011070)1.58337161
153Precocious puberty (HP:0000826)1.58074734
154Broad phalanges of the hand (HP:0009768)1.57754666
155Supernumerary spleens (HP:0009799)1.56426854
156Short thorax (HP:0010306)1.55107231
157Dyschromatopsia (HP:0007641)1.54349338
158Deformed sella turcica (HP:0002681)1.54086383
159Median cleft lip (HP:0000161)1.53353219
160Aplasia/Hypoplasia of the fibula (HP:0006492)1.52940174
161Abnormal biliary tract physiology (HP:0012439)1.52510750
162Bile duct proliferation (HP:0001408)1.52510750
163Abnormality of the dental pulp (HP:0006479)1.52075859
164Broad distal phalanx of finger (HP:0009836)1.43477398
165Abnormality of ocular smooth pursuit (HP:0000617)1.42896377
166Nephropathy (HP:0000112)1.40838846
167Cystic liver disease (HP:0006706)1.40824583
168Aplasia/Hypoplasia of the tongue (HP:0010295)1.39236053
169Conjunctival telangiectasia (HP:0000524)1.39142277
170Decreased motor nerve conduction velocity (HP:0003431)1.39118161
171Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.36773280
172Abnormal urine output (HP:0012590)1.36339214
17311 pairs of ribs (HP:0000878)1.34294005
174Pachygyria (HP:0001302)1.33527705
175Decreased central vision (HP:0007663)1.33527623
176Choroideremia (HP:0001139)1.32014730
177Pancreatic fibrosis (HP:0100732)1.31440031
178Short femoral neck (HP:0100864)1.26611125
179Polyuria (HP:0000103)1.24535466
180Cerebellar dysplasia (HP:0007033)1.22325098
181Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.21339096
182Difficulty walking (HP:0002355)1.20881620
183Gaze-evoked nystagmus (HP:0000640)1.20494588
184Abnormality of saccadic eye movements (HP:0000570)1.19976635
185Difficulty climbing stairs (HP:0003551)1.19483707

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.53785758
2PDK38.53785758
3TESK15.53393063
4PDK25.52363147
5PRKD34.58073525
6ICK3.76015993
7BRD42.79961463
8PTK2B2.72798203
9PNCK2.69614632
10SIK22.68021071
11MARK12.60024443
12WNK42.41914691
13STK392.30863615
14CAMK1D2.03299833
15NEK21.92643418
16TRIB31.92020466
17AKT31.81088664
18DDR21.70502876
19STK381.62587104
20KSR21.59992939
21MAP3K61.59640104
22INSRR1.42025984
23SGK21.39550787
24RPS6KA21.38749368
25SGK2231.35195546
26SGK4941.35195546
27NTRK11.18563702
28CASK1.14370679
29DYRK1B1.12816791
30MAPK151.11827352
31MAPK131.10029029
32WNK11.09015908
33KSR11.05658575
34NTRK31.04834825
35TYRO31.01084272
36SGK31.00001048
37MAP2K40.96847993
38TAOK30.95998537
39PDK10.92608862
40LATS10.88876615
41STK30.88387260
42TNK20.86559565
43ZAK0.85291894
44PASK0.84320199
45CDC70.82043520
46CCNB10.80302594
47PRKD20.76920044
48PAK30.75989548
49ERBB20.75064332
50DAPK20.74153803
51RET0.73982522
52CAMK1G0.73225138
53SIK10.72892355
54PRKAA20.72447115
55DYRK30.71883397
56PKN10.71827255
57TTK0.70893051
58BLK0.69242924
59RPS6KC10.68813689
60RPS6KL10.68813689
61EPHB20.66721786
62RPS6KA60.66424916
63WEE10.65441278
64MAP3K70.64685528
65PKN20.62503913
66FGFR20.60654099
67CAMK10.57892535
68MAP2K30.57677718
69MAP2K20.57647882
70MATK0.56745592
71PINK10.56588877
72PHKG10.55946282
73PHKG20.55946282
74SGK10.54838703
75PIK3CG0.53810591
76MET0.53219151
77PLK20.51712659
78CHEK20.51539997
79CHEK10.50390766
80EEF2K0.49848230
81ATR0.49634803
82LMTK20.47949548
83RAF10.47527838
84IRAK10.47283539
85CAMK40.45807780
86CDK50.45069451
87DYRK1A0.43276734
88PDPK10.40325272
89TESK20.39987582
90AKT10.39943746
91TXK0.37872570
92MTOR0.37789658
93ATM0.36788108
94MAP3K110.36414073
95PAK10.32995964
96MAP2K60.31551867
97STK38L0.30213703
98PAK20.29700762
99PLK40.29322388
100NTRK20.27268071
101NEK60.25735595
102PRKAA10.24221664
103CAMKK10.22565382
104CDK120.22286389
105PRKCG0.22278053
106PLK10.22038426
107RPS6KB10.21661587
108IRAK20.19713980
109MARK20.18956655
110MUSK0.18834098
111RIPK40.17788410
112BMPR1B0.12902611
113MAPKAPK50.11634981
114BRSK20.10636060
115PAK40.10522062
116MAP3K40.09294124
117WNK30.08590460
118CSNK1D0.08368430
119ZAP700.07759124
120CDK10.06992030
121CDK20.06393395
122PRKCQ0.06274573
123GSK3B0.06269134
124PAK60.06080406
125PRKCZ0.05455308
126PDGFRB0.04224180
127CSNK2A10.04184269
128MAPK80.04167200
129PRKDC0.03663773
130STK100.03659724
131RPS6KA10.03574076
132CSF1R0.03307708
133STK110.03205592
134TAOK10.01908898
135MAP2K70.01678839
136PRKG10.01422445
137PRKACG0.01168881
138CSNK2A20.00959581
139PRKACB0.00957724
140BRAF0.00751348
141MARK30.00119443
142BRSK10.00087661
143EPHB1-0.0385333
144CDK11A-0.0317451
145CDK3-0.0288762
146CAMK2A-0.0274622
147CDK18-0.0272659
148CDK6-0.0232351
149CSK-0.0209599
150MAPK10-0.0165203
151MAPK1-0.0163026
152RPS6KA3-0.0154376
153RIPK1-0.0136021
154MAP3K10-0.0122967
155CDK4-0.0113227
156EGFR-0.0081139
157CDK15-0.0058005
158PRKCB-0.0037345

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.33384281
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.22351064
3Pyruvate metabolism_Homo sapiens_hsa006204.17755282
4Fatty acid biosynthesis_Homo sapiens_hsa000613.47207852
5Propanoate metabolism_Homo sapiens_hsa006403.21652721
6Glucagon signaling pathway_Homo sapiens_hsa049222.83118929
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.64885767
8Dorso-ventral axis formation_Homo sapiens_hsa043202.63884458
9Selenocompound metabolism_Homo sapiens_hsa004502.60349548
10Basal transcription factors_Homo sapiens_hsa030222.55690349
11Linoleic acid metabolism_Homo sapiens_hsa005912.52615165
12Pentose phosphate pathway_Homo sapiens_hsa000302.43226821
13Fanconi anemia pathway_Homo sapiens_hsa034602.36038634
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13336216
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03194150
16Glycerolipid metabolism_Homo sapiens_hsa005612.02969431
17Nicotine addiction_Homo sapiens_hsa050332.00610568
18Lysine degradation_Homo sapiens_hsa003101.99903501
19Oocyte meiosis_Homo sapiens_hsa041141.96125096
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.91484787
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.88465584
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86692012
23Huntingtons disease_Homo sapiens_hsa050161.78629386
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.76463428
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72327122
26PPAR signaling pathway_Homo sapiens_hsa033201.67493753
27Glutamatergic synapse_Homo sapiens_hsa047241.64360429
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.57026422
29Amphetamine addiction_Homo sapiens_hsa050311.56868413
30Notch signaling pathway_Homo sapiens_hsa043301.54326018
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.52340018
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.50480917
33Fructose and mannose metabolism_Homo sapiens_hsa000511.49509752
34mRNA surveillance pathway_Homo sapiens_hsa030151.45795900
35Carbon metabolism_Homo sapiens_hsa012001.42342998
36Olfactory transduction_Homo sapiens_hsa047401.37703985
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33922425
38RNA transport_Homo sapiens_hsa030131.33553844
39Choline metabolism in cancer_Homo sapiens_hsa052311.32709566
40Antigen processing and presentation_Homo sapiens_hsa046121.31754916
41Renin secretion_Homo sapiens_hsa049241.28440794
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.22111725
43Cocaine addiction_Homo sapiens_hsa050301.21397934
44Cardiac muscle contraction_Homo sapiens_hsa042601.19473502
45Fat digestion and absorption_Homo sapiens_hsa049751.18918510
46Morphine addiction_Homo sapiens_hsa050321.18471101
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17314207
48Cholinergic synapse_Homo sapiens_hsa047251.16662586
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.12465708
50Ether lipid metabolism_Homo sapiens_hsa005651.12298858
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12186963
52Fatty acid metabolism_Homo sapiens_hsa012121.11312350
53Type II diabetes mellitus_Homo sapiens_hsa049301.10738925
54Non-small cell lung cancer_Homo sapiens_hsa052231.07829801
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07044442
56Sulfur relay system_Homo sapiens_hsa041221.05760051
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04787818
58Axon guidance_Homo sapiens_hsa043601.04583262
59Long-term depression_Homo sapiens_hsa047301.04448921
60Fatty acid degradation_Homo sapiens_hsa000711.02443791
61Prolactin signaling pathway_Homo sapiens_hsa049170.99899071
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98872642
63MAPK signaling pathway_Homo sapiens_hsa040100.98822654
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96813660
65ErbB signaling pathway_Homo sapiens_hsa040120.95552012
66mTOR signaling pathway_Homo sapiens_hsa041500.95184892
67Phototransduction_Homo sapiens_hsa047440.92879225
68ABC transporters_Homo sapiens_hsa020100.91536330
69Mineral absorption_Homo sapiens_hsa049780.91033146
70Biosynthesis of amino acids_Homo sapiens_hsa012300.90355017
71Purine metabolism_Homo sapiens_hsa002300.88414511
72T cell receptor signaling pathway_Homo sapiens_hsa046600.87074530
73Endometrial cancer_Homo sapiens_hsa052130.86260252
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86162376
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84641846
76Long-term potentiation_Homo sapiens_hsa047200.82791785
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82122066
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.81872504
79Dopaminergic synapse_Homo sapiens_hsa047280.80458654
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80251705
81Estrogen signaling pathway_Homo sapiens_hsa049150.79423816
82GnRH signaling pathway_Homo sapiens_hsa049120.78083633
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77395206
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73887201
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.73757667
86GABAergic synapse_Homo sapiens_hsa047270.71104167
87Butanoate metabolism_Homo sapiens_hsa006500.70910533
88Glioma_Homo sapiens_hsa052140.69159906
89Gap junction_Homo sapiens_hsa045400.69159754
90Oxytocin signaling pathway_Homo sapiens_hsa049210.68897367
91Acute myeloid leukemia_Homo sapiens_hsa052210.68068036
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67876027
93Glutathione metabolism_Homo sapiens_hsa004800.66989297
94Systemic lupus erythematosus_Homo sapiens_hsa053220.66336356
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.66134195
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64528819
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64191480
98Serotonergic synapse_Homo sapiens_hsa047260.63065499
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62616274
100Legionellosis_Homo sapiens_hsa051340.62156150
101Basal cell carcinoma_Homo sapiens_hsa052170.61729724
102Renin-angiotensin system_Homo sapiens_hsa046140.60276280
103Colorectal cancer_Homo sapiens_hsa052100.59412047
104FoxO signaling pathway_Homo sapiens_hsa040680.58928346
105Chronic myeloid leukemia_Homo sapiens_hsa052200.58630807
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58109127
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57668982
108Bladder cancer_Homo sapiens_hsa052190.56466139
109Hedgehog signaling pathway_Homo sapiens_hsa043400.56175772
110AMPK signaling pathway_Homo sapiens_hsa041520.55727642
111Circadian rhythm_Homo sapiens_hsa047100.55211600
112Insulin signaling pathway_Homo sapiens_hsa049100.54213610
113Calcium signaling pathway_Homo sapiens_hsa040200.53595687
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52669220
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52496004
116Hippo signaling pathway_Homo sapiens_hsa043900.52220398
117Arachidonic acid metabolism_Homo sapiens_hsa005900.52053937
118Endocytosis_Homo sapiens_hsa041440.51627487
119Melanogenesis_Homo sapiens_hsa049160.51383695
120Insulin resistance_Homo sapiens_hsa049310.51189028
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49666547
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48921024
123Prostate cancer_Homo sapiens_hsa052150.48663084
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48356978
125VEGF signaling pathway_Homo sapiens_hsa043700.47252647
126Chemical carcinogenesis_Homo sapiens_hsa052040.46445564
127Insulin secretion_Homo sapiens_hsa049110.46359023
128N-Glycan biosynthesis_Homo sapiens_hsa005100.44422492
129Pancreatic cancer_Homo sapiens_hsa052120.43969115
130Thyroid hormone synthesis_Homo sapiens_hsa049180.43596387
131Bile secretion_Homo sapiens_hsa049760.42333514
132Inositol phosphate metabolism_Homo sapiens_hsa005620.40127516
133Taste transduction_Homo sapiens_hsa047420.38406056
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36797519
135RNA degradation_Homo sapiens_hsa030180.35021723
136Homologous recombination_Homo sapiens_hsa034400.31377952
137Alcoholism_Homo sapiens_hsa050340.30227318
138Metabolic pathways_Homo sapiens_hsa011000.28816617
139Collecting duct acid secretion_Homo sapiens_hsa049660.27696310
140Circadian entrainment_Homo sapiens_hsa047130.27683268
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27190017
142Viral carcinogenesis_Homo sapiens_hsa052030.26824804
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.26415473
144Protein digestion and absorption_Homo sapiens_hsa049740.25955872
145Pancreatic secretion_Homo sapiens_hsa049720.23929362
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23812977
147cAMP signaling pathway_Homo sapiens_hsa040240.20440722
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20190327
149Gastric acid secretion_Homo sapiens_hsa049710.20000922
150Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19581234
151Salivary secretion_Homo sapiens_hsa049700.18837718
152B cell receptor signaling pathway_Homo sapiens_hsa046620.17955328
153Synaptic vesicle cycle_Homo sapiens_hsa047210.17830154
154Cell cycle_Homo sapiens_hsa041100.17202129
155Salmonella infection_Homo sapiens_hsa051320.14916288
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14175013
157Wnt signaling pathway_Homo sapiens_hsa043100.13263536
158Sphingolipid metabolism_Homo sapiens_hsa006000.12995686
159Pyrimidine metabolism_Homo sapiens_hsa002400.11561454

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