QRSL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1telomere maintenance via semi-conservative replication (GO:0032201)4.46125994
2DNA strand elongation involved in DNA replication (GO:0006271)4.43386825
3nucleobase biosynthetic process (GO:0046112)4.36230761
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.35244096
5ribosomal small subunit assembly (GO:0000028)4.32854026
6purine nucleobase biosynthetic process (GO:0009113)4.29059267
7DNA strand elongation (GO:0022616)4.22985112
8telomere maintenance via recombination (GO:0000722)4.19341891
9respiratory chain complex IV assembly (GO:0008535)4.19056190
10IMP biosynthetic process (GO:0006188)4.03399023
11DNA replication initiation (GO:0006270)3.99147533
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.98223407
13formation of translation preinitiation complex (GO:0001731)3.96323106
14energy coupled proton transport, down electrochemical gradient (GO:0015985)3.95563920
15ATP synthesis coupled proton transport (GO:0015986)3.95563920
16CENP-A containing nucleosome assembly (GO:0034080)3.93601595
17spliceosomal snRNP assembly (GO:0000387)3.89747656
18cytochrome complex assembly (GO:0017004)3.83549394
19mitotic recombination (GO:0006312)3.83143497
20nucleotide-excision repair, DNA gap filling (GO:0006297)3.79778802
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.79084151
22chromatin remodeling at centromere (GO:0031055)3.77500379
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.77236399
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.75666408
25DNA double-strand break processing (GO:0000729)3.71517420
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.67317236
27negative regulation of ligase activity (GO:0051352)3.65756413
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.65756413
29spliceosomal complex assembly (GO:0000245)3.57171650
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57033802
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.57033802
32NADH dehydrogenase complex assembly (GO:0010257)3.57033802
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54177492
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53712281
35water-soluble vitamin biosynthetic process (GO:0042364)3.53178579
36maturation of SSU-rRNA (GO:0030490)3.52424892
37oxidative phosphorylation (GO:0006119)3.50915801
38regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.48584418
39regulation of mitotic spindle checkpoint (GO:1903504)3.48584418
40replication fork processing (GO:0031297)3.48540960
41maturation of 5.8S rRNA (GO:0000460)3.48367351
42IMP metabolic process (GO:0046040)3.47389006
43viral mRNA export from host cell nucleus (GO:0046784)3.44910678
44regulation of nuclear cell cycle DNA replication (GO:0033262)3.43955594
45DNA unwinding involved in DNA replication (GO:0006268)3.43391878
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42686919
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42686919
48telomere maintenance via telomere lengthening (GO:0010833)3.42548683
49tricarboxylic acid cycle (GO:0006099)3.41590881
50DNA replication-independent nucleosome organization (GO:0034724)3.41188836
51DNA replication-independent nucleosome assembly (GO:0006336)3.41188836
52NADH metabolic process (GO:0006734)3.40791552
53mitotic metaphase plate congression (GO:0007080)3.40270322
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39365901
55proteasome assembly (GO:0043248)3.39039923
56protein complex biogenesis (GO:0070271)3.38893343
577-methylguanosine mRNA capping (GO:0006370)3.37111874
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35251797
59transcription-coupled nucleotide-excision repair (GO:0006283)3.33936648
60DNA replication checkpoint (GO:0000076)3.33574185
61establishment of integrated proviral latency (GO:0075713)3.33351645
62somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.33084000
63somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.33084000
64isotype switching (GO:0045190)3.33084000
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.33039907
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.33039907
677-methylguanosine RNA capping (GO:0009452)3.31238331
68RNA capping (GO:0036260)3.31238331
69cullin deneddylation (GO:0010388)3.31130359
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.30091373
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.30091373
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.30091373
73regulation of cellular amino acid metabolic process (GO:0006521)3.28496001
74mitochondrial respiratory chain complex assembly (GO:0033108)3.27354321
75signal transduction involved in DNA damage checkpoint (GO:0072422)3.25329377
76signal transduction involved in DNA integrity checkpoint (GO:0072401)3.25329377
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.22205251
78signal transduction involved in cell cycle checkpoint (GO:0072395)3.21624539
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.21504582
80ribosome biogenesis (GO:0042254)3.18803441
81DNA deamination (GO:0045006)3.18163262
82metallo-sulfur cluster assembly (GO:0031163)3.16866570
83iron-sulfur cluster assembly (GO:0016226)3.16866570
84protein localization to chromosome, centromeric region (GO:0071459)3.16703813
85kinetochore organization (GO:0051383)3.16199585
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.14518888
87protein K6-linked ubiquitination (GO:0085020)3.14348362
88recombinational repair (GO:0000725)3.13385904
89mitotic sister chromatid segregation (GO:0000070)3.12964990
90pseudouridine synthesis (GO:0001522)3.12883843
91G1/S transition of mitotic cell cycle (GO:0000082)3.11538030
92cell cycle G1/S phase transition (GO:0044843)3.11538030
93histone exchange (GO:0043486)3.11445905
94double-strand break repair via homologous recombination (GO:0000724)3.10049538
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09606568
96protein localization to kinetochore (GO:0034501)3.09472964
97respiratory electron transport chain (GO:0022904)3.08779650
98DNA damage response, detection of DNA damage (GO:0042769)3.07295254
99positive regulation of ligase activity (GO:0051351)3.06646766
100ubiquinone biosynthetic process (GO:0006744)3.05787514
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.05368774
102protein neddylation (GO:0045116)3.05171251
103GMP metabolic process (GO:0046037)3.04957900
104DNA catabolic process, exonucleolytic (GO:0000738)3.04786510
105electron transport chain (GO:0022900)3.03518014
106protein deneddylation (GO:0000338)3.03142639
107rRNA catabolic process (GO:0016075)3.01062717
108establishment of protein localization to mitochondrial membrane (GO:0090151)3.00995375
109regulation of ubiquitin-protein transferase activity (GO:0051438)3.00002598
110termination of RNA polymerase III transcription (GO:0006386)2.99928294
111transcription elongation from RNA polymerase III promoter (GO:0006385)2.99928294
112DNA ligation (GO:0006266)2.98610226
113ribonucleoprotein complex biogenesis (GO:0022613)2.98605750
114somatic hypermutation of immunoglobulin genes (GO:0016446)2.98500915
115somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98500915
116protein-cofactor linkage (GO:0018065)2.97946295
117regulation of mitochondrial translation (GO:0070129)2.96660909
118ubiquinone metabolic process (GO:0006743)2.96211792
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96122701
120anterograde synaptic vesicle transport (GO:0048490)2.95931599
121mitochondrial RNA metabolic process (GO:0000959)2.95042342
122mitotic nuclear envelope disassembly (GO:0007077)2.94920604
123transcription elongation from RNA polymerase I promoter (GO:0006362)2.94623368
124ribosomal large subunit biogenesis (GO:0042273)2.94348154
125tRNA processing (GO:0008033)2.92415440
126double-strand break repair via nonhomologous end joining (GO:0006303)2.92401778
127non-recombinational repair (GO:0000726)2.92401778
128cellular component biogenesis (GO:0044085)2.91277019
129metaphase plate congression (GO:0051310)2.90795354
130guanosine-containing compound biosynthetic process (GO:1901070)2.90136779
131attachment of spindle microtubules to kinetochore (GO:0008608)2.89007789
132histone mRNA metabolic process (GO:0008334)2.88515412
133meiotic chromosome segregation (GO:0045132)2.88048615
134regulation of ligase activity (GO:0051340)2.87839859
135antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.87073294
136resolution of meiotic recombination intermediates (GO:0000712)2.86040836
137kinetochore assembly (GO:0051382)2.84904556
138establishment of chromosome localization (GO:0051303)2.84267846
139rRNA modification (GO:0000154)2.84019334
140negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83911601
141negative regulation of sister chromatid segregation (GO:0033046)2.83911601
142rRNA methylation (GO:0031167)2.83279012
143synapsis (GO:0007129)2.81170888
144inner mitochondrial membrane organization (GO:0007007)2.79185423
145somatic diversification of immunoglobulins (GO:0016445)2.78229544
146prenylation (GO:0097354)2.78045993
147protein prenylation (GO:0018342)2.78045993
148somatic diversification of immune receptors (GO:0002200)2.76996433
149* tRNA metabolic process (GO:0006399)2.74730621
150somatic cell DNA recombination (GO:0016444)2.72796448
151somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.72796448
152spindle checkpoint (GO:0031577)2.72579170
153somatic recombination of immunoglobulin gene segments (GO:0016447)2.72364319
154transcription from mitochondrial promoter (GO:0006390)2.70932853
155reciprocal DNA recombination (GO:0035825)2.68849606
156reciprocal meiotic recombination (GO:0007131)2.68849606
157regulation of hexokinase activity (GO:1903299)2.65783935
158regulation of glucokinase activity (GO:0033131)2.65783935
159DNA recombination (GO:0006310)2.64987152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.36700625
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.43806160
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.27698559
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91350596
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.87226120
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.65508979
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.63586204
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59129118
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.40080646
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37590471
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.24182729
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.19840064
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19604707
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.10454754
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93389426
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91569352
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88651786
18ZNF274_21170338_ChIP-Seq_K562_Hela2.74682721
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61449106
20VDR_23849224_ChIP-Seq_CD4+_Human2.54684245
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45723003
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45619758
23VDR_22108803_ChIP-Seq_LS180_Human2.38428104
24FOXP3_21729870_ChIP-Seq_TREG_Human2.35147498
25XRN2_22483619_ChIP-Seq_HELA_Human2.33420501
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33144215
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27445526
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.27123862
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22719187
30EWS_26573619_Chip-Seq_HEK293_Human2.22580048
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20284288
32DCP1A_22483619_ChIP-Seq_HELA_Human2.18684918
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17718394
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15738923
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.09287760
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06537596
37GABP_19822575_ChIP-Seq_HepG2_Human2.06460049
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02468241
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.99279971
40* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99065082
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98214214
42CIITA_25753668_ChIP-Seq_RAJI_Human1.97363440
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.97076927
44FUS_26573619_Chip-Seq_HEK293_Human1.96036940
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.95516995
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92856454
47TTF2_22483619_ChIP-Seq_HELA_Human1.92630234
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86515107
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.84538515
50* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84496587
51IGF1R_20145208_ChIP-Seq_DFB_Human1.83841784
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82252183
53AR_21909140_ChIP-Seq_LNCAP_Human1.82021600
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81294382
55ELK1_19687146_ChIP-ChIP_HELA_Human1.80071990
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78033613
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77737469
58TAF15_26573619_Chip-Seq_HEK293_Human1.75418532
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73843618
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62143058
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60638522
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60584250
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59281271
64* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52464594
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48361412
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47821969
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46426551
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44391189
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40797791
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38926095
71MYC_22102868_ChIP-Seq_BL_Human1.35156753
72P300_19829295_ChIP-Seq_ESCs_Human1.34704549
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34630834
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33613910
75KDM5A_27292631_Chip-Seq_BREAST_Human1.29847046
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27583780
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26905215
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26804254
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25193783
80* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24406069
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24398187
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23434672
83IRF1_19129219_ChIP-ChIP_H3396_Human1.19394692
84TP53_22573176_ChIP-Seq_HFKS_Human1.19015509
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14480054
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13699567
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12740120
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12385199
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12315872
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11273552
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.10670844
92GBX2_23144817_ChIP-Seq_PC3_Human1.09539250
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09297798
94ER_23166858_ChIP-Seq_MCF-7_Human1.08440773
95* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07194270
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06559429
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.05049162
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.04651601
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02519610
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01155112
101* EZH2_27294783_Chip-Seq_NPCs_Mouse1.01049156
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00567320
103* MYC_18940864_ChIP-ChIP_HL60_Human1.00410408
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99027921
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98980469
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98689518
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98627652
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.98392428
109PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98363962
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97437576
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97238097
112CBP_20019798_ChIP-Seq_JUKART_Human0.96252485
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96252485
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94938356
115TFEB_21752829_ChIP-Seq_HELA_Human0.93952019
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93509700
117KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93197914
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91648468
119* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91435950
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91138240
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89392179
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89172117
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88737546
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88139520
125* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87326169
126* CRX_20693478_ChIP-Seq_RETINA_Mouse0.87174586
127FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87002099
128FOXA1_25329375_ChIP-Seq_VCAP_Human0.87002099
129SOX2_19829295_ChIP-Seq_ESCs_Human0.84298736
130NANOG_19829295_ChIP-Seq_ESCs_Human0.84298736
131AR_20517297_ChIP-Seq_VCAP_Human0.82069498
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81696380
133CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79085962
134GATA4_21415370_ChIP-Seq_HL-1_Mouse0.78172351
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77576211
136FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77170463
137SPI1_23547873_ChIP-Seq_NB4_Human0.76127116
138* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75529503
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.67304815
140SOX17_20123909_ChIP-Seq_XEN_Mouse0.65908332
141HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65249059
142CTCF_18555785_ChIP-Seq_MESCs_Mouse0.64206164
143NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.60143900
144* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.58850462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.08657520
2MP0010094_abnormal_chromosome_stability4.05589813
3MP0004957_abnormal_blastocyst_morpholog3.78830353
4MP0008057_abnormal_DNA_replication3.63034247
5MP0008058_abnormal_DNA_repair3.59909974
6MP0003111_abnormal_nucleus_morphology3.46122801
7MP0003077_abnormal_cell_cycle3.24329593
8MP0004084_abnormal_cardiac_muscle3.16437613
9MP0000372_irregular_coat_pigmentation2.86110210
10MP0003646_muscle_fatigue2.85299898
11MP0000751_myopathy2.63412817
12MP0001986_abnormal_taste_sensitivity2.61042523
13MP0006036_abnormal_mitochondrial_physio2.55560467
14MP0008877_abnormal_DNA_methylation2.46841282
15MP0002396_abnormal_hematopoietic_system2.44141223
16MP0000749_muscle_degeneration2.44045618
17MP0004215_abnormal_myocardial_fiber2.42306038
18MP0002837_dystrophic_cardiac_calcinosis2.38351592
19MP0002102_abnormal_ear_morphology2.28598639
20MP0008932_abnormal_embryonic_tissue2.27354957
21MP0001188_hyperpigmentation2.26355131
22MP0003123_paternal_imprinting2.24483193
23MP0008007_abnormal_cellular_replicative2.13403493
24MP0003136_yellow_coat_color2.11299265
25MP0004036_abnormal_muscle_relaxation2.06315349
26MP0006035_abnormal_mitochondrial_morpho2.02351299
27MP0003787_abnormal_imprinting2.02196056
28MP0005330_cardiomyopathy1.94797035
29MP0003221_abnormal_cardiomyocyte_apopto1.92415920
30MP0001730_embryonic_growth_arrest1.82860857
31MP0001529_abnormal_vocalization1.81260359
32MP0004147_increased_porphyrin_level1.79820571
33MP0003786_premature_aging1.78709778
34MP0005174_abnormal_tail_pigmentation1.72602253
35MP0005084_abnormal_gallbladder_morpholo1.59815124
36MP0002938_white_spotting1.54156685
37MP0005645_abnormal_hypothalamus_physiol1.50451994
38MP0003567_abnormal_fetal_cardiomyocyte1.46838962
39MP0002127_abnormal_cardiovascular_syste1.46732428
40MP0005253_abnormal_eye_physiology1.40834793
41MP0000015_abnormal_ear_pigmentation1.40504700
42MP0000350_abnormal_cell_proliferation1.40294133
43MP0006072_abnormal_retinal_apoptosis1.34760020
44MP0000569_abnormal_digit_pigmentation1.33924426
45MP0001293_anophthalmia1.33725276
46MP0002269_muscular_atrophy1.33592962
47MP0004233_abnormal_muscle_weight1.32780965
48MP0002972_abnormal_cardiac_muscle1.32219575
49MP0006276_abnormal_autonomic_nervous1.31486654
50MP0008789_abnormal_olfactory_epithelium1.30673886
51MP0001324_abnormal_eye_pigmentation1.28851831
52MP0001697_abnormal_embryo_size1.28319415
53MP0003718_maternal_effect1.27115803
54MP0009379_abnormal_foot_pigmentation1.27071926
55MP0002106_abnormal_muscle_physiology1.24063570
56MP0005620_abnormal_muscle_contractility1.23835854
57MP0008775_abnormal_heart_ventricle1.21622773
58MP0001727_abnormal_embryo_implantation1.21053686
59MP0000427_abnormal_hair_cycle1.20769144
60MP0002080_prenatal_lethality1.19888368
61MP0005266_abnormal_metabolism1.18964498
62MP0004484_altered_response_of1.18766454
63MP0004145_abnormal_muscle_electrophysio1.18638979
64MP0003984_embryonic_growth_retardation1.17899552
65MP0003890_abnormal_embryonic-extraembry1.17472427
66MP0001672_abnormal_embryogenesis/_devel1.15176077
67MP0005380_embryogenesis_phenotype1.15176077
68MP0004087_abnormal_muscle_fiber1.14932582
69MP0002088_abnormal_embryonic_growth/wei1.12830895
70MP0000313_abnormal_cell_death1.12230964
71MP0004142_abnormal_muscle_tone1.10821835
72MP0003137_abnormal_impulse_conducting1.08506807
73MP0003121_genomic_imprinting1.08180700
74MP0003186_abnormal_redox_activity1.07700519
75MP0005385_cardiovascular_system_phenoty1.07553071
76MP0001544_abnormal_cardiovascular_syste1.07553071
77MP0002638_abnormal_pupillary_reflex1.06412277
78MP0006292_abnormal_olfactory_placode1.06410984
79MP0003195_calcinosis1.05202603
80MP0010630_abnormal_cardiac_muscle1.04725893
81MP0009697_abnormal_copulation1.02888504
82MP0000750_abnormal_muscle_regeneration1.02590372
83MP0004085_abnormal_heartbeat1.02366298
84MP0006138_congestive_heart_failure1.02330129
85MP0000631_abnormal_neuroendocrine_gland1.01667461
86MP0002234_abnormal_pharynx_morphology1.01603638
87MP0002822_catalepsy1.00943565
88MP0002095_abnormal_skin_pigmentation1.00516917
89MP0005075_abnormal_melanosome_morpholog1.00033300
90MP0002019_abnormal_tumor_incidence0.99353437
91MP0003806_abnormal_nucleotide_metabolis0.97613442
92MP0005379_endocrine/exocrine_gland_phen0.97593013
93MP0001764_abnormal_homeostasis0.97514687
94MP0003011_delayed_dark_adaptation0.96309905
95MP0000358_abnormal_cell_content/0.95792074
96MP0002210_abnormal_sex_determination0.94386123
97MP0001984_abnormal_olfaction0.92317597
98MP0000747_muscle_weakness0.92121005
99MP0002398_abnormal_bone_marrow0.91999673
100MP0008995_early_reproductive_senescence0.91855363
101MP0002160_abnormal_reproductive_system0.90683835
102MP0005408_hypopigmentation0.89587283
103MP0009046_muscle_twitch0.89426600
104MP0002163_abnormal_gland_morphology0.89363788
105MP0002332_abnormal_exercise_endurance0.89049841
106MP0002009_preneoplasia0.89002870
107MP0003763_abnormal_thymus_physiology0.88863839
108MP0000647_abnormal_sebaceous_gland0.88634285
109MP0002928_abnormal_bile_duct0.88412387
110MP0002876_abnormal_thyroid_physiology0.87987033
111MP0004043_abnormal_pH_regulation0.87727291
112MP0004808_abnormal_hematopoietic_stem0.87439944
113MP0000653_abnormal_sex_gland0.87199569
114MP0000689_abnormal_spleen_morphology0.86076302
115MP0002722_abnormal_immune_system0.86027853
116MP0005369_muscle_phenotype0.85921099
117MP0000703_abnormal_thymus_morphology0.85589877
118MP0005423_abnormal_somatic_nervous0.84486805
119MP0009333_abnormal_splenocyte_physiolog0.84052282
120MP0008872_abnormal_physiological_respon0.83783059
121MP0000759_abnormal_skeletal_muscle0.82113203
122MP0003315_abnormal_perineum_morphology0.81895329
123MP0002138_abnormal_hepatobiliary_system0.80929305
124MP0005389_reproductive_system_phenotype0.80816486
125MP0005391_vision/eye_phenotype0.80665157
126MP0002085_abnormal_embryonic_tissue0.79930682
127MP0006054_spinal_hemorrhage0.79634241
128MP0004133_heterotaxia0.79113786
129MP0001485_abnormal_pinna_reflex0.79102011
130MP0003937_abnormal_limbs/digits/tail_de0.78934137
131MP0005646_abnormal_pituitary_gland0.78490563
132MP0001905_abnormal_dopamine_level0.77908278
133MP0004742_abnormal_vestibular_system0.77692577
134MP0003698_abnormal_male_reproductive0.77614646
135MP0001119_abnormal_female_reproductive0.77550829
136MP0002277_abnormal_respiratory_mucosa0.76832259
137MP0001929_abnormal_gametogenesis0.76389957
138MP0002751_abnormal_autonomic_nervous0.75870419
139MP0002090_abnormal_vision0.75229947
140MP0002429_abnormal_blood_cell0.74594727
141MP0000490_abnormal_crypts_of0.73758532
142MP0001145_abnormal_male_reproductive0.73115230
143MP0002653_abnormal_ependyma_morphology0.72182638
144MP0005551_abnormal_eye_electrophysiolog0.71748945
145MP0003880_abnormal_central_pattern0.70387569
146MP0002075_abnormal_coat/hair_pigmentati0.70345695
147MP0008875_abnormal_xenobiotic_pharmacok0.70286581
148MP0009672_abnormal_birth_weight0.69387702
149MP0000371_diluted_coat_color0.68719528
150MP0005394_taste/olfaction_phenotype0.68263245
151MP0005499_abnormal_olfactory_system0.68263245
152MP0001835_abnormal_antigen_presentation0.66752791
153MP0003943_abnormal_hepatobiliary_system0.65791693
154MP0001800_abnormal_humoral_immune0.65460869
155MP0000716_abnormal_immune_system0.63960748
156MP0003828_pulmonary_edema0.61433723
157MP0002086_abnormal_extraembryonic_tissu0.59416307
158MP0002084_abnormal_developmental_patter0.58297802

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)4.94521091
2Acute necrotizing encephalopathy (HP:0006965)4.85651610
3Mitochondrial inheritance (HP:0001427)4.32182765
4Hepatocellular necrosis (HP:0001404)4.29151194
5Increased CSF lactate (HP:0002490)4.16026004
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.14039358
7Abnormality of alanine metabolism (HP:0010916)4.14039358
8Hyperalaninemia (HP:0003348)4.14039358
9Decreased activity of mitochondrial respiratory chain (HP:0008972)4.05357627
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.05357627
11Hepatic necrosis (HP:0002605)4.05143857
12Acute encephalopathy (HP:0006846)4.05056797
13Congenital stationary night blindness (HP:0007642)3.87584320
14Progressive macrocephaly (HP:0004481)3.82247373
15Exercise intolerance (HP:0003546)3.56012851
16Abnormality of glycolysis (HP:0004366)3.54069363
17Increased serum pyruvate (HP:0003542)3.54069363
18Birth length less than 3rd percentile (HP:0003561)3.53974154
19Increased serum lactate (HP:0002151)3.52075705
20Lactic acidosis (HP:0003128)3.32519243
21Increased intramyocellular lipid droplets (HP:0012240)3.23775636
22Hyperglycinemia (HP:0002154)3.03622587
23Palpitations (HP:0001962)3.03043852
24Methylmalonic acidemia (HP:0002912)3.02226599
25Cerebral hypomyelination (HP:0006808)3.01142644
26Increased hepatocellular lipid droplets (HP:0006565)2.99755028
27Carpal bone hypoplasia (HP:0001498)2.99508201
28Respiratory failure (HP:0002878)2.96544116
29Abnormal number of erythroid precursors (HP:0012131)2.90678085
30Increased muscle lipid content (HP:0009058)2.88829036
31Abnormality of midbrain morphology (HP:0002418)2.88438195
32Molar tooth sign on MRI (HP:0002419)2.88438195
33Abnormality of cells of the erythroid lineage (HP:0012130)2.84025093
34Cerebral edema (HP:0002181)2.82168416
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80947266
36Pancreatic cysts (HP:0001737)2.80364585
37Lipid accumulation in hepatocytes (HP:0006561)2.77466745
38Rhabdomyolysis (HP:0003201)2.76206417
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.72379312
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.68002227
41Pancreatic fibrosis (HP:0100732)2.66443111
42Ragged-red muscle fibers (HP:0003200)2.64907848
43Colon cancer (HP:0003003)2.62778904
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.60502872
45Oral leukoplakia (HP:0002745)2.60290321
46Neoplasm of the adrenal cortex (HP:0100641)2.59796986
47Breast hypoplasia (HP:0003187)2.59761715
48Exercise-induced myalgia (HP:0003738)2.59565817
49Methylmalonic aciduria (HP:0012120)2.58694892
50True hermaphroditism (HP:0010459)2.55688257
51B lymphocytopenia (HP:0010976)2.53481296
52Optic disc pallor (HP:0000543)2.50447050
53Myoglobinuria (HP:0002913)2.49870130
54Emotional lability (HP:0000712)2.49800692
55Panhypogammaglobulinemia (HP:0003139)2.46574332
56Abnormality of B cell number (HP:0010975)2.46148589
57Sudden death (HP:0001699)2.44055157
583-Methylglutaconic aciduria (HP:0003535)2.42192139
59Medial flaring of the eyebrow (HP:0010747)2.42127299
60Aplastic anemia (HP:0001915)2.38687248
61Unsteady gait (HP:0002317)2.37053795
62Hypoplasia of the capital femoral epiphysis (HP:0003090)2.36032039
63Calf muscle hypertrophy (HP:0008981)2.33635744
64Respiratory difficulties (HP:0002880)2.33239237
65IgM deficiency (HP:0002850)2.32625684
66Abnormality of glycine metabolism (HP:0010895)2.32487238
67Abnormality of serine family amino acid metabolism (HP:0010894)2.32487238
68Agnosia (HP:0010524)2.30039973
69Patellar aplasia (HP:0006443)2.28621588
70Abnormality of the preputium (HP:0100587)2.27086999
71CNS demyelination (HP:0007305)2.26922361
72Abnormality of serum amino acid levels (HP:0003112)2.25418800
73Abnormality of the labia minora (HP:0012880)2.24927133
74Exercise-induced muscle cramps (HP:0003710)2.23409468
75Muscle hypertrophy of the lower extremities (HP:0008968)2.22601267
76Renal cortical cysts (HP:0000803)2.20815483
77Volvulus (HP:0002580)2.20781180
78Hypoplasia of the pons (HP:0012110)2.17265661
79Reticulocytopenia (HP:0001896)2.17202453
80Thyroiditis (HP:0100646)2.16686272
81Nephronophthisis (HP:0000090)2.16605750
82Hyperglycinuria (HP:0003108)2.15783121
83Ependymoma (HP:0002888)2.15506784
84Exertional dyspnea (HP:0002875)2.11248511
85Aplasia/Hypoplasia of the patella (HP:0006498)2.11022986
86Ventricular tachycardia (HP:0004756)2.10913474
87Neoplasm of the adrenal gland (HP:0100631)2.09429596
88Severe combined immunodeficiency (HP:0004430)2.08454860
89Bile duct proliferation (HP:0001408)2.08290820
90Abnormal biliary tract physiology (HP:0012439)2.08290820
91Abnormality of the renal cortex (HP:0011035)2.07896887
92Microretrognathia (HP:0000308)2.06034383
93Renal Fanconi syndrome (HP:0001994)2.05543593
94Lipoatrophy (HP:0100578)2.03966610
95Abnormality of chromosome stability (HP:0003220)2.02399949
96Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00786320
97Rough bone trabeculation (HP:0100670)2.00222649
98Sclerocornea (HP:0000647)1.99539841
99Severe visual impairment (HP:0001141)1.98861932
100Progressive inability to walk (HP:0002505)1.98822723
101Inability to walk (HP:0002540)1.98311609
102Abnormal lung lobation (HP:0002101)1.97537704
103Bone marrow hypocellularity (HP:0005528)1.96510008
104Neuroendocrine neoplasm (HP:0100634)1.96332765
105Duodenal stenosis (HP:0100867)1.95149018
106Small intestinal stenosis (HP:0012848)1.95149018
107Abnormality of the pons (HP:0007361)1.94987121
108Leukodystrophy (HP:0002415)1.94921700
109Congenital primary aphakia (HP:0007707)1.93272522
110Supraventricular tachycardia (HP:0004755)1.91402981
111Absent thumb (HP:0009777)1.90985862
112Intestinal atresia (HP:0011100)1.90625437
113Clubbing of toes (HP:0100760)1.90484979
114Gait imbalance (HP:0002141)1.89721637
115Combined immunodeficiency (HP:0005387)1.88841657
116IgG deficiency (HP:0004315)1.88808642
117Atrial fibrillation (HP:0005110)1.87616287
118Abnormal rod and cone electroretinograms (HP:0008323)1.87001114
119Pancytopenia (HP:0001876)1.86163836
120Lethargy (HP:0001254)1.85419890
121Abnormality of the vitamin B12 metabolism (HP:0004341)1.84519814
122Nephrogenic diabetes insipidus (HP:0009806)1.84006116
123Abnormality of the renal medulla (HP:0100957)1.83580199
124Macrocytic anemia (HP:0001972)1.83379752
125Meckel diverticulum (HP:0002245)1.83367869
126Premature graying of hair (HP:0002216)1.82413540
127Abnormality of methionine metabolism (HP:0010901)1.82381807
128Supraventricular arrhythmia (HP:0005115)1.82353574
129Abnormality of the calf musculature (HP:0001430)1.81886509
130Asplenia (HP:0001746)1.81566675
131Agammaglobulinemia (HP:0004432)1.80292901
132Microvesicular hepatic steatosis (HP:0001414)1.80193815
133Abnormality of the ileum (HP:0001549)1.80179874
134Type 2 muscle fiber atrophy (HP:0003554)1.79916582
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79557751
136Chronic hepatic failure (HP:0100626)1.79413401
137Primary atrial arrhythmia (HP:0001692)1.78736961
138Cellular immunodeficiency (HP:0005374)1.78563620
139Type I transferrin isoform profile (HP:0003642)1.78498011
140Abnormality of vitamin B metabolism (HP:0004340)1.78324271
141Attenuation of retinal blood vessels (HP:0007843)1.77845992
142Homocystinuria (HP:0002156)1.76787951
143Abnormality of homocysteine metabolism (HP:0010919)1.76787951
144Aplasia/Hypoplasia of the spleen (HP:0010451)1.75425975
145Progressive muscle weakness (HP:0003323)1.75372472
146Postnatal microcephaly (HP:0005484)1.74764634
147Dandy-Walker malformation (HP:0001305)1.73847950
148Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73196966
149Multiple enchondromatosis (HP:0005701)1.72747261
150Dilated cardiomyopathy (HP:0001644)1.72680006
151Sloping forehead (HP:0000340)1.71925383
152Abnormality of the duodenum (HP:0002246)1.71834876
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71048418
154Absent epiphyses (HP:0010577)1.71048418
155Astigmatism (HP:0000483)1.70809459
156Chromsome breakage (HP:0040012)1.67246826
157Myelodysplasia (HP:0002863)1.67204459
158Neoplasm of the colon (HP:0100273)1.66361039
159Constricted visual fields (HP:0001133)1.65030535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.70096601
2WEE14.13055051
3STK163.64924930
4NEK13.45252476
5TSSK63.42054691
6CCNB12.98975180
7BMPR1B2.96380527
8FRK2.90106378
9EIF2AK12.56255122
10WNK32.36171578
11CDC72.30892846
12PDK22.18489602
13EIF2AK32.17839568
14NME22.12727550
15SRPK12.08928921
16TRIM282.06713579
17PLK42.06114996
18NUAK12.02945072
19VRK22.02464321
20BRSK22.00537054
21MAP4K21.89417451
22PDK41.72747876
23PDK31.72747876
24OBSCN1.71444315
25TAOK31.70141687
26VRK11.64011570
27MYLK1.62683252
28MAP3K121.61144315
29NEK21.56193810
30PLK11.54088127
31TTK1.49403397
32NME11.49395736
33PLK31.48876757
34STK241.42650990
35MAP3K41.39868759
36BCKDK1.36604279
37AURKB1.34816633
38TAF11.31677860
39CDK81.29227255
40CSNK1G11.24183472
41TNIK1.22883919
42ADRBK21.21379485
43CSNK1G31.20063903
44PBK1.18922087
45BRSK11.18789606
46SIK31.16203560
47ACVR1B1.14369085
48MAP4K11.13647670
49BCR1.12088378
50INSRR1.11238003
51DYRK31.11219075
52DAPK11.10957975
53ATR1.07008752
54CSNK1G21.06761472
55DYRK21.01158119
56CDK71.01018015
57CSNK1A1L0.99545087
58ZAK0.98822474
59MAPK130.98777229
60AURKA0.97169158
61MAP2K70.94937970
62ERBB30.90592045
63MKNK10.90442869
64OXSR10.89887538
65CHEK20.88527143
66STK40.85771128
67RPS6KB20.85112637
68PASK0.84495308
69RPS6KA40.83457549
70GRK60.82498848
71TTN0.82301088
72STK38L0.77687860
73CHEK10.77387116
74CSNK2A20.73440969
75CDK40.70395678
76KDR0.70309213
77TESK20.69398410
78PNCK0.69099944
79PINK10.67906816
80CSNK2A10.66694911
81TIE10.66092156
82PRKCI0.63434604
83TGFBR10.62253071
84TLK10.62132637
85WNK40.61964407
86PAK40.60445541
87LIMK10.60284407
88AKT30.59145434
89EIF2AK20.57898071
90MKNK20.57846944
91PLK20.55305728
92STK30.55156949
93MAP3K110.54436931
94AKT20.52670233
95SYK0.52185025
96ILK0.52061841
97UHMK10.49763881
98ADRBK10.48748639
99CSF1R0.48644894
100CDK20.48352738
101ATM0.46624625
102MST40.45577045
103TEC0.44478703
104STK390.44313584
105PKN10.43411626
106NLK0.42983815
107PHKG20.42000272
108PHKG10.42000272
109YES10.41874074
110CAMK2A0.41627013
111CSNK1E0.41208756
112TNK20.41012095
113ALK0.39225743
114PRKACB0.38856421
115PIK3CG0.38721474
116CDK10.38349744
117CASK0.38172159
118BRAF0.37165818
119MARK30.37033371
120CDK30.36715808
121TESK10.36643204
122CDK190.35905293
123PRKCE0.35620052
124PRKCG0.35257587
125BRD40.35128317
126EPHA20.35085682
127CSNK1A10.34308969
128CAMKK20.33880465
129BTK0.33624444
130RPS6KA50.32197922
131CSNK1D0.30596892
132PAK30.30075687
133GRK10.28836060
134PRKDC0.28687718
135PIM20.28414022
136MINK10.28263279
137MAP3K100.27784014
138LYN0.24134287
139PIM10.23354378
140PAK10.22843273
141TXK0.22705659
142MAP3K80.22579068
143KIT0.21897839
144MAPK120.21855281
145SCYL20.21707799

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.40110457
2Proteasome_Homo sapiens_hsa030504.36274470
3Mismatch repair_Homo sapiens_hsa034303.81061660
4RNA polymerase_Homo sapiens_hsa030203.26489425
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.26155930
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01660573
7Homologous recombination_Homo sapiens_hsa034402.98193090
8Ribosome_Homo sapiens_hsa030102.94248850
9Spliceosome_Homo sapiens_hsa030402.90229761
10Oxidative phosphorylation_Homo sapiens_hsa001902.81586118
11Parkinsons disease_Homo sapiens_hsa050122.77777793
12Base excision repair_Homo sapiens_hsa034102.64131424
13Nucleotide excision repair_Homo sapiens_hsa034202.53649106
14RNA transport_Homo sapiens_hsa030132.47091544
15* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29767157
16Pyrimidine metabolism_Homo sapiens_hsa002402.22738397
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13645469
18Huntingtons disease_Homo sapiens_hsa050162.10819776
19Cell cycle_Homo sapiens_hsa041101.94971324
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94063586
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94025029
22Non-homologous end-joining_Homo sapiens_hsa034501.93096548
23Alzheimers disease_Homo sapiens_hsa050101.83614275
24Fanconi anemia pathway_Homo sapiens_hsa034601.78044257
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75618849
26Cardiac muscle contraction_Homo sapiens_hsa042601.73830720
27Purine metabolism_Homo sapiens_hsa002301.59743930
28Butanoate metabolism_Homo sapiens_hsa006501.58112283
29RNA degradation_Homo sapiens_hsa030181.58060231
30Phototransduction_Homo sapiens_hsa047441.54140635
31Basal transcription factors_Homo sapiens_hsa030221.48438544
32Carbon metabolism_Homo sapiens_hsa012001.42109921
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40772829
34One carbon pool by folate_Homo sapiens_hsa006701.36621547
35mRNA surveillance pathway_Homo sapiens_hsa030151.35479755
36Biosynthesis of amino acids_Homo sapiens_hsa012301.21819986
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.12523078
38Caffeine metabolism_Homo sapiens_hsa002321.10032658
39Epstein-Barr virus infection_Homo sapiens_hsa051691.08401970
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05076576
41Pyruvate metabolism_Homo sapiens_hsa006201.03632720
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02961918
43Protein export_Homo sapiens_hsa030600.99364402
44Tryptophan metabolism_Homo sapiens_hsa003800.93785066
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93349572
46Oocyte meiosis_Homo sapiens_hsa041140.90355205
47Peroxisome_Homo sapiens_hsa041460.88838056
48Fatty acid elongation_Homo sapiens_hsa000620.88670137
49Pentose phosphate pathway_Homo sapiens_hsa000300.87644889
50Fructose and mannose metabolism_Homo sapiens_hsa000510.86282963
51Nitrogen metabolism_Homo sapiens_hsa009100.78608486
52Propanoate metabolism_Homo sapiens_hsa006400.76093558
53Linoleic acid metabolism_Homo sapiens_hsa005910.75160154
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74888685
55Primary immunodeficiency_Homo sapiens_hsa053400.74630319
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70437190
57p53 signaling pathway_Homo sapiens_hsa041150.70278371
58Folate biosynthesis_Homo sapiens_hsa007900.67629245
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65792764
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61641963
61Vitamin B6 metabolism_Homo sapiens_hsa007500.61598780
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61293585
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61168095
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61052990
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59761242
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59718115
67Steroid biosynthesis_Homo sapiens_hsa001000.58444229
68Antigen processing and presentation_Homo sapiens_hsa046120.56414992
69Fatty acid metabolism_Homo sapiens_hsa012120.56209381
70Systemic lupus erythematosus_Homo sapiens_hsa053220.54806646
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53388802
72* Metabolic pathways_Homo sapiens_hsa011000.52123310
73Sulfur metabolism_Homo sapiens_hsa009200.48783737
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.48702975
75Galactose metabolism_Homo sapiens_hsa000520.48219669
76Dilated cardiomyopathy_Homo sapiens_hsa054140.47738877
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47335146
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47097146
79Olfactory transduction_Homo sapiens_hsa047400.44747338
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43742712
81Fatty acid degradation_Homo sapiens_hsa000710.41850608
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41557599
83Herpes simplex infection_Homo sapiens_hsa051680.39501854
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38900719
85Nicotine addiction_Homo sapiens_hsa050330.38153992
86Regulation of autophagy_Homo sapiens_hsa041400.37821469
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.37784852
88Ether lipid metabolism_Homo sapiens_hsa005650.37259647
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36957416
90beta-Alanine metabolism_Homo sapiens_hsa004100.35912236
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.33809393
92Retinol metabolism_Homo sapiens_hsa008300.32073693
93Chemical carcinogenesis_Homo sapiens_hsa052040.30778090
94Vibrio cholerae infection_Homo sapiens_hsa051100.29903035
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29831528
96HIF-1 signaling pathway_Homo sapiens_hsa040660.29538437
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.29509139
98HTLV-I infection_Homo sapiens_hsa051660.29210549
99Phenylalanine metabolism_Homo sapiens_hsa003600.28791562
100N-Glycan biosynthesis_Homo sapiens_hsa005100.28423078
101Collecting duct acid secretion_Homo sapiens_hsa049660.27781769
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.27434557
103Viral carcinogenesis_Homo sapiens_hsa052030.26827073
104Viral myocarditis_Homo sapiens_hsa054160.23490173
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22682037
106Legionellosis_Homo sapiens_hsa051340.21325093
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20466129
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20114750
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19813907
110Lysine degradation_Homo sapiens_hsa003100.19471505
111Synaptic vesicle cycle_Homo sapiens_hsa047210.18967958
112Alcoholism_Homo sapiens_hsa050340.18246409
113Autoimmune thyroid disease_Homo sapiens_hsa053200.16620149
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16371073
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.15889277
116Arginine and proline metabolism_Homo sapiens_hsa003300.15479559
117Circadian rhythm_Homo sapiens_hsa047100.15219819
118Allograft rejection_Homo sapiens_hsa053300.14970858
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.14358850
120Asthma_Homo sapiens_hsa053100.13930042
121Taste transduction_Homo sapiens_hsa047420.11911234
122Tyrosine metabolism_Homo sapiens_hsa003500.10079383
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.10035700
124Glucagon signaling pathway_Homo sapiens_hsa049220.09671005
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08949931
126Glutathione metabolism_Homo sapiens_hsa004800.05489447
127Dopaminergic synapse_Homo sapiens_hsa047280.03712637
128Thyroid cancer_Homo sapiens_hsa052160.03590885
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.03456886
130Selenocompound metabolism_Homo sapiens_hsa004500.03335246
131Calcium signaling pathway_Homo sapiens_hsa040200.02237500
132Hematopoietic cell lineage_Homo sapiens_hsa046400.01732382
133Sulfur relay system_Homo sapiens_hsa041220.00513482
134Glycerolipid metabolism_Homo sapiens_hsa00561-0.0153916
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0148821
136Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0037774
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0029565

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