QRSL1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of Wnt signaling pathway involved in heart development (GO:0003307)9.33734474
2pericardium development (GO:0060039)7.66334394
3cartilage morphogenesis (GO:0060536)7.16824532
4positive regulation of megakaryocyte differentiation (GO:0045654)6.29345482
5regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901216.28954967
6neurotransmitter metabolic process (GO:0042133)6.24967409
7regulation of establishment of cell polarity (GO:2000114)6.22096520
8dorsal/ventral axis specification (GO:0009950)5.86844404
9regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)5.80572103
10regulation of non-canonical Wnt signaling pathway (GO:2000050)5.55250429
11regulation of establishment or maintenance of cell polarity (GO:0032878)5.54245399
12protein localization to kinetochore (GO:0034501)5.29760925
13positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)5.18599698
14phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.96528231
15cell surface receptor signaling pathway involved in heart development (GO:0061311)4.76090964
16glycoprotein catabolic process (GO:0006516)4.73109285
17replication fork processing (GO:0031297)4.71280430
18regulation of mesoderm development (GO:2000380)4.69997932
19negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.53271215
20endoderm formation (GO:0001706)4.46474063
21cardiac epithelial to mesenchymal transition (GO:0060317)4.36872916
22mitotic metaphase plate congression (GO:0007080)4.35179457
23embryonic retina morphogenesis in camera-type eye (GO:0060059)4.33450452
24organ growth (GO:0035265)4.30936921
25negative regulation of hormone biosynthetic process (GO:0032353)4.25508781
26mitochondrial DNA replication (GO:0006264)4.20452377
27protein localization to chromosome, centromeric region (GO:0071459)4.09754811
28positive regulation of developmental pigmentation (GO:0048087)4.08483433
29endothelial cell proliferation (GO:0001935)4.04005613
30DNA replication-dependent nucleosome assembly (GO:0006335)3.93685520
31DNA replication-dependent nucleosome organization (GO:0034723)3.93685520
32positive regulation of cardiac muscle cell differentiation (GO:2000727)3.89419757
33valine metabolic process (GO:0006573)3.86320981
34genitalia morphogenesis (GO:0035112)3.79849380
35zinc ion transmembrane transport (GO:0071577)3.79738008
36metaphase plate congression (GO:0051310)3.76958240
37regulation of pigment cell differentiation (GO:0050932)3.75719326
38regulation of activin receptor signaling pathway (GO:0032925)3.71176939
39gonadal mesoderm development (GO:0007506)3.70122651
40primitive streak formation (GO:0090009)3.67159090
41negative regulation of cardiac muscle tissue development (GO:0055026)3.65385175
42regulation of cardiac muscle cell differentiation (GO:2000725)3.62039710
43seminiferous tubule development (GO:0072520)3.59076201
44positive regulation of osteoblast proliferation (GO:0033690)3.56389903
45negative regulation of hormone metabolic process (GO:0032351)3.54708253
46signal transduction involved in regulation of gene expression (GO:0023019)3.50718669
47regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)3.45849837
48regulation of neuron migration (GO:2001222)3.43778733
49mitochondrial RNA metabolic process (GO:0000959)3.43127523
50transcription from mitochondrial promoter (GO:0006390)3.40462700
51negative regulation of activin receptor signaling pathway (GO:0032926)3.37762029
52mitotic sister chromatid segregation (GO:0000070)3.37385229
53nodal signaling pathway (GO:0038092)3.34489080
54embryonic foregut morphogenesis (GO:0048617)3.31934146
55thalamus development (GO:0021794)3.31465699
56SMAD protein complex assembly (GO:0007183)3.30210960
57cell migration involved in gastrulation (GO:0042074)3.29241659
58regulation of megakaryocyte differentiation (GO:0045652)3.28634550
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.24239753
60female gonad development (GO:0008585)3.22448375
61epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.22314783
62DNA replication checkpoint (GO:0000076)3.22242848
63sulfate transmembrane transport (GO:1902358)3.19256310
64positive regulation of astrocyte differentiation (GO:0048711)3.14561643
65regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.12906719
66mesenchymal cell differentiation (GO:0048762)3.12135158
67negative regulation of myotube differentiation (GO:0010832)3.07239791
68DNA strand renaturation (GO:0000733)3.06717535
69kinetochore assembly (GO:0051382)3.05557081
70ureteric bud development (GO:0001657)3.04661714
71maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.03851849
72cellular component maintenance (GO:0043954)3.03767585
73establishment of protein localization to Golgi (GO:0072600)3.01941418
74regulation of smooth muscle cell differentiation (GO:0051150)3.01461699
75protein K6-linked ubiquitination (GO:0085020)3.00530165
76sister chromatid segregation (GO:0000819)2.96488300
77negative regulation of smooth muscle cell differentiation (GO:0051151)2.92825288
78regulation of acyl-CoA biosynthetic process (GO:0050812)2.91421672
79negative regulation of keratinocyte proliferation (GO:0010839)2.88399085
80endosome to pigment granule transport (GO:0043485)2.86272631
81endosome to melanosome transport (GO:0035646)2.86272631
82negative regulation of striated muscle cell differentiation (GO:0051154)2.84150031
83piRNA metabolic process (GO:0034587)2.82933946
84sulfate transport (GO:0008272)2.81256482
85gastrulation (GO:0007369)2.79526383
86response to cholesterol (GO:0070723)2.79415072
87radial glial cell differentiation (GO:0060019)2.78992960
88outflow tract septum morphogenesis (GO:0003148)2.78317351
89kinetochore organization (GO:0051383)2.76743989
90response to folic acid (GO:0051593)2.76038682
91positive regulation of meiosis (GO:0045836)2.74954747
92regulation of sulfur metabolic process (GO:0042762)2.72789199
93toxin transport (GO:1901998)2.71352485
94activin receptor signaling pathway (GO:0032924)2.68208408
95protein targeting to Golgi (GO:0000042)2.68146395
96mitochondrial DNA metabolic process (GO:0032042)2.66929658
97regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.66670941
98apical protein localization (GO:0045176)2.66629284
99embryonic hindlimb morphogenesis (GO:0035116)2.64945351
100neurotransmitter catabolic process (GO:0042135)16.5265477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.54822345
2FUS_26573619_Chip-Seq_HEK293_Human3.53679998
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.53042686
4ZFP57_27257070_Chip-Seq_ESCs_Mouse3.10482973
5BCAT_22108803_ChIP-Seq_LS180_Human2.98434386
6TAF15_26573619_Chip-Seq_HEK293_Human2.92155025
7VDR_22108803_ChIP-Seq_LS180_Human2.79753834
8EWS_26573619_Chip-Seq_HEK293_Human2.40773215
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38922360
10ZNF274_21170338_ChIP-Seq_K562_Hela2.36709201
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.36664153
12P300_19829295_ChIP-Seq_ESCs_Human2.33721016
13AR_21909140_ChIP-Seq_LNCAP_Human2.29918935
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22852096
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19333444
16SMAD3_21741376_ChIP-Seq_EPCs_Human2.11479922
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.97193508
18EZH2_22144423_ChIP-Seq_EOC_Human1.95182817
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94070013
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88026995
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.83783985
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81673610
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81640702
24TCF4_22108803_ChIP-Seq_LS180_Human1.76306170
25IGF1R_20145208_ChIP-Seq_DFB_Human1.76151087
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75674177
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.68303183
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66116931
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65148788
30GBX2_23144817_ChIP-Seq_PC3_Human1.63705982
31E2F7_22180533_ChIP-Seq_HELA_Human1.62772679
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61848288
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60625235
34ER_23166858_ChIP-Seq_MCF-7_Human1.59357311
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58092540
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57367508
37IRF1_19129219_ChIP-ChIP_H3396_Human1.57192628
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56539811
39TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.55031443
40STAT3_23295773_ChIP-Seq_U87_Human1.52055455
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.48598494
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.47189794
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.44467762
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.44003762
45SMAD4_21799915_ChIP-Seq_A2780_Human1.43470766
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.43329514
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42999598
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39953250
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39953250
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39953250
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37468685
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.36603477
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.35840628
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35365069
55RNF2_27304074_Chip-Seq_NSC_Mouse1.32475671
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.32065489
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32044480
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31932629
59AR_25329375_ChIP-Seq_VCAP_Human1.31890489
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31436315
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29727465
62MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29195158
63AR_21572438_ChIP-Seq_LNCaP_Human1.27841091
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27299682
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.25290802
66TCF4_23295773_ChIP-Seq_U87_Human1.24560311
67SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.24460272
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22239750
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.21645034
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21400483
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.19833519
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19655988
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.17512183
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17227319
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17209435
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15854110
77ELK1_19687146_ChIP-ChIP_HELA_Human1.15840456
78RUNX2_22187159_ChIP-Seq_PCA_Human1.14706765
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14360854
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14360854
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13201879
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.11181596
83MYC_18940864_ChIP-ChIP_HL60_Human1.09651217
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08029117
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05842660
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04994602
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.04994602
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.03863822
89OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03755871
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03371688
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03298272
92JUN_21703547_ChIP-Seq_K562_Human1.02972013
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.02602919
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01418306
95KDM2B_26808549_Chip-Seq_REH_Human0.99843583
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97403761
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96467041
98CBP_20019798_ChIP-Seq_JUKART_Human0.96139933
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96139933
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95890009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry6.74827321
2MP0002249_abnormal_larynx_morphology4.47613385
3MP0002282_abnormal_trachea_morphology3.96902440
4MP0008004_abnormal_stomach_pH3.81392380
5MP0010368_abnormal_lymphatic_system3.40112946
6MP0009250_abnormal_appendicular_skeleto3.37605370
7MP0003937_abnormal_limbs/digits/tail_de2.73494421
8MP0005076_abnormal_cell_differentiation2.69343761
9MP0003787_abnormal_imprinting2.46362607
10MP0000013_abnormal_adipose_tissue2.38468991
11MP0009053_abnormal_anal_canal2.12688550
12MP0003195_calcinosis2.08322500
13MP0004147_increased_porphyrin_level1.99848028
14MP0005408_hypopigmentation1.87393503
15MP0003943_abnormal_hepatobiliary_system1.78435746
16MP0000428_abnormal_craniofacial_morphol1.72811113
17MP0000579_abnormal_nail_morphology1.69738941
18MP0000049_abnormal_middle_ear1.59342136
19MP0010094_abnormal_chromosome_stability1.58581417
20MP0000537_abnormal_urethra_morphology1.53879717
21MP0008877_abnormal_DNA_methylation1.51467542
22MP0001485_abnormal_pinna_reflex1.50917334
23MP0002933_joint_inflammation1.46346244
24MP0004197_abnormal_fetal_growth/weight/1.46313592
25MP0003935_abnormal_craniofacial_develop1.42333093
26MP0003567_abnormal_fetal_cardiomyocyte1.41449371
27MP0005551_abnormal_eye_electrophysiolog1.41417602
28MP0003119_abnormal_digestive_system1.40113303
29MP0002084_abnormal_developmental_patter1.37687887
30MP0002697_abnormal_eye_size1.37044395
31MP0005380_embryogenesis_phenotype1.36559853
32MP0001672_abnormal_embryogenesis/_devel1.36559853
33MP0001293_anophthalmia1.36196435
34MP0002876_abnormal_thyroid_physiology1.27353491
35MP0002111_abnormal_tail_morphology1.24147263
36MP0009697_abnormal_copulation1.23702939
37MP0003121_genomic_imprinting1.22774030
38MP0001661_extended_life_span1.20785259
39MP0000003_abnormal_adipose_tissue1.17391829
40MP0002109_abnormal_limb_morphology1.15885722
41MP0000371_diluted_coat_color1.15498573
42MP0000516_abnormal_urinary_system1.13664905
43MP0005367_renal/urinary_system_phenotyp1.13664905
44MP0000163_abnormal_cartilage_morphology1.13057731
45MP0004145_abnormal_muscle_electrophysio1.12679593
46MP0002210_abnormal_sex_determination1.10677389
47MP0010329_abnormal_lipoprotein_level1.07936774
48MP0004272_abnormal_basement_membrane1.07472798
49MP0003646_muscle_fatigue1.05543386
50MP0005187_abnormal_penis_morphology1.05431364
51MP0003755_abnormal_palate_morphology1.04663664
52MP0005499_abnormal_olfactory_system1.04597244
53MP0005394_taste/olfaction_phenotype1.04597244
54MP0003115_abnormal_respiratory_system1.03755540
55MP0003984_embryonic_growth_retardation1.03612129
56MP0003385_abnormal_body_wall1.02322146
57MP0010030_abnormal_orbit_morphology0.99802629
58MP0000383_abnormal_hair_follicle0.98817068
59MP0002088_abnormal_embryonic_growth/wei0.98592129
60MP0000762_abnormal_tongue_morphology0.98050158
61MP0006292_abnormal_olfactory_placode0.97220827
62MP0000631_abnormal_neuroendocrine_gland0.96510594
63MP0001929_abnormal_gametogenesis0.94661631
64MP0004142_abnormal_muscle_tone0.94001745
65MP0001145_abnormal_male_reproductive0.93044707
66MP0003959_abnormal_lean_body0.91003877
67MP0004133_heterotaxia0.90538600
68MP0003718_maternal_effect0.90085000
69MP0000653_abnormal_sex_gland0.87463709
70MP0002086_abnormal_extraembryonic_tissu0.87346656
71MP0000372_irregular_coat_pigmentation0.86990234
72MP0005646_abnormal_pituitary_gland0.86748091
73MP0004957_abnormal_blastocyst_morpholog0.85026283
74MP0003136_yellow_coat_color0.84994137
75MP0006054_spinal_hemorrhage0.84113332
76MP0003077_abnormal_cell_cycle0.83443812
77MP0000538_abnormal_urinary_bladder0.80386143
78MP0001984_abnormal_olfaction0.80268228
79MP0001730_embryonic_growth_arrest0.77789633
80MP0000432_abnormal_head_morphology0.76825222
81MP0000647_abnormal_sebaceous_gland0.74288768
82MP0001286_abnormal_eye_development0.74261613
83MP0002098_abnormal_vibrissa_morphology0.72306199
84MP0002932_abnormal_joint_morphology0.72282248
85MP0003786_premature_aging0.71605468
86MP0002736_abnormal_nociception_after0.69376769
87MP0009703_decreased_birth_body0.68422514
88MP0002229_neurodegeneration0.67849833
89MP0001963_abnormal_hearing_physiology0.65187447
90MP0004134_abnormal_chest_morphology0.64879813
91MP0004885_abnormal_endolymph0.64847085
92MP0002102_abnormal_ear_morphology0.64691362
93MP0002160_abnormal_reproductive_system0.64306962
94MP0002116_abnormal_craniofacial_bone0.64174475
95MP0003942_abnormal_urinary_system0.63059651
96MP0002295_abnormal_pulmonary_circulatio0.62948521
97MP0002234_abnormal_pharynx_morphology0.62940036
98MP0002115_abnormal_skeleton_extremities0.62844891
99MP0001666_abnormal_nutrient_absorption0.62632145
100MP0001119_abnormal_female_reproductive0.62063901

Predicted human phenotypes

RankGene SetZ-score
1Bell-shaped thorax (HP:0001591)6.36709470
2Abnormality of the lumbar spine (HP:0100712)5.50873085
3Volvulus (HP:0002580)5.32372267
4Enlarged kidneys (HP:0000105)5.25403900
5Abnormality of alanine metabolism (HP:0010916)5.24035075
6Hyperalaninemia (HP:0003348)5.24035075
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.24035075
8Embryonal renal neoplasm (HP:0011794)5.21453998
9Disproportionate short-trunk short stature (HP:0003521)5.13571113
10Tracheomalacia (HP:0002779)4.99754673
11Missing ribs (HP:0000921)4.95450701
12Myelomeningocele (HP:0002475)3.87943269
13Abnormal vertebral ossification (HP:0100569)3.82772132
14Thrombocytosis (HP:0001894)3.62327624
15Protuberant abdomen (HP:0001538)3.37657219
16Spontaneous abortion (HP:0005268)3.37609160
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27439303
18Hypoplastic labia majora (HP:0000059)3.17034433
19Chromsome breakage (HP:0040012)3.13830578
20Hypochromic microcytic anemia (HP:0004840)3.13617517
21Abnormality of the phalanges of the 2nd finger (HP:0009541)2.96999804
22Abnormality of the ileum (HP:0001549)2.96646301
23Absent radius (HP:0003974)2.95679845
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.93005348
25Aplastic anemia (HP:0001915)2.91954397
26Abnormality of the labia majora (HP:0012881)2.86044145
27Tubulointerstitial nephritis (HP:0001970)2.80161893
28Aplasia involving forearm bones (HP:0009822)2.78354037
29Absent forearm bone (HP:0003953)2.78354037
30Shawl scrotum (HP:0000049)2.76468400
31Adactyly (HP:0009776)2.73706873
32Abnormality of chromosome stability (HP:0003220)2.71694259
33Meckel diverticulum (HP:0002245)2.71493564
34Hyperventilation (HP:0002883)2.63185571
35Nephronophthisis (HP:0000090)2.57553251
36Supernumerary spleens (HP:0009799)2.50719700
37Prominent supraorbital ridges (HP:0000336)2.50295582
38Abnormality of the left ventricular outflow tract (HP:0011103)2.48449633
39Subaortic stenosis (HP:0001682)2.48449633
40Oligohydramnios (HP:0001562)2.48233078
41Myelodysplasia (HP:0002863)2.47348441
42Abnormality of the preputium (HP:0100587)2.36505524
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.35987918
44Abnormality of the middle phalanges of the toes (HP:0010183)2.35578626
45Triphalangeal thumb (HP:0001199)2.35437815
46Birth length less than 3rd percentile (HP:0003561)2.33645485
47Generalized hypopigmentation of hair (HP:0011358)2.33068289
48Hypoplasia of the fovea (HP:0007750)2.28092793
49Aplasia/Hypoplasia of the fovea (HP:0008060)2.28092793
50Respiratory difficulties (HP:0002880)2.22764526
51Respiratory distress (HP:0002098)2.22708251
52Clubbing of toes (HP:0100760)2.22628918
53Tubular atrophy (HP:0000092)2.21326924
54Abnormality of the renal medulla (HP:0100957)2.21088777
55Thickened helices (HP:0000391)2.14366447
56Small intestinal stenosis (HP:0012848)2.10708222
57Duodenal stenosis (HP:0100867)2.10708222
58Abnormality of the parietal bone (HP:0002696)2.09890760
59Abdominal situs inversus (HP:0003363)2.09657777
60Abnormality of abdominal situs (HP:0011620)2.09657777
61Cortical dysplasia (HP:0002539)2.08540521
62Abnormal auditory evoked potentials (HP:0006958)2.08338180
63Molar tooth sign on MRI (HP:0002419)2.03091765
64Abnormality of midbrain morphology (HP:0002418)2.03091765
65Bifid tongue (HP:0010297)2.02795224
66Short hallux (HP:0010109)1.98872538
67Preaxial foot polydactyly (HP:0001841)1.98520992
68Anterior segment dysgenesis (HP:0007700)1.91461431
69Labial hypoplasia (HP:0000066)1.88577791
70Pancreatic islet-cell hyperplasia (HP:0004510)1.85706303
71Pancreatic cysts (HP:0001737)1.83131171
72Protruding tongue (HP:0010808)1.81677933
73Meningocele (HP:0002435)1.81092907
74Astigmatism (HP:0000483)1.80763695
75Polymicrogyria (HP:0002126)1.80625946
76Sloping forehead (HP:0000340)1.79789492
77Intestinal atresia (HP:0011100)1.79620371
78Abnormality of the duodenum (HP:0002246)1.78154412
79Tented upper lip vermilion (HP:0010804)1.77231163
80Aplasia/Hypoplasia of the hallux (HP:0008362)1.77107975
81Exotropia (HP:0000577)1.76754928
82Hypoplastic female external genitalia (HP:0012815)1.75625639
83Depressed nasal ridge (HP:0000457)1.75407736
84Bilateral sensorineural hearing impairment (HP:0008619)1.74675967
85Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.73478063
862-3 toe syndactyly (HP:0004691)1.72279621
87Pancreatic fibrosis (HP:0100732)1.69832465
88Aplasia cutis congenita (HP:0001057)1.69775900
89Abnormality of the carotid arteries (HP:0005344)1.68644222
90Drooling (HP:0002307)1.68387445
91Capillary hemangiomas (HP:0005306)1.68257190
92True hermaphroditism (HP:0010459)1.67942218
93Nephroblastoma (Wilms tumor) (HP:0002667)1.67805592
94Absent speech (HP:0001344)1.66289113
95Asplenia (HP:0001746)1.66192272
96Anhidrosis (HP:0000970)1.65551843
97Congenital hepatic fibrosis (HP:0002612)1.63326207
98Tubulointerstitial abnormality (HP:0001969)1.62450923
99Renal agenesis (HP:0000104)1.61900394
100Gastroesophageal reflux (HP:0002020)1.60971847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B9.56408657
2BMPR1B6.59662910
3TLK13.86284269
4ZAK3.51188337
5TGFBR13.17596220
6CASK3.04044275
7TNIK2.98025473
8FLT32.89369773
9PKN22.82078752
10FRK2.13218625
11MELK1.85886723
12TIE11.65378730
13PLK41.65372862
14STK101.58520865
15LATS11.38525741
16VRK11.35814343
17ADRBK11.33227990
18MST41.15732982
19CDC71.10386210
20MATK1.06606979
21BUB11.06339115
22WNK41.04771395
23TRIM280.99627771
24PRKD30.99443610
25TEC0.98895169
26NME10.97428421
27BCKDK0.94027162
28PNCK0.93911685
29INSRR0.92200768
30CSNK1G10.90352443
31MKNK20.87132511
32STK240.83291753
33CAMK1G0.82911742
34AKT30.79580071
35STK30.78271680
36STK38L0.76025241
37LATS20.72790107
38LRRK20.69128124
39WEE10.66034556
40FGFR10.65201655
41PBK0.63557171
42CAMK1D0.62696316
43GRK10.57601175
44NTRK10.57250104
45BCR0.56106969
46MAP2K10.54611277
47ADRBK20.54110386
48NLK0.51317598
49KDR0.51209863
50MET0.51094565
51TXK0.51070979
52SIK30.50573537
53PRKCQ0.49443410
54CHEK20.47184584
55SIK10.46654495
56MKNK10.46255289
57PHKG10.46004069
58PHKG20.46004069
59PIM10.45454273
60MAPK130.45106795
61PLK10.42514339
62NTRK30.42068571
63TSSK60.38813705
64ERBB40.37154150
65DAPK20.36683234
66JAK20.33472120
67STK390.33195363
68PRKACB0.32947147
69NEK20.31130396
70STK40.29227923
71ATM0.26038851
72PRKAA20.24509039
73CDK120.22648624
74IGF1R0.22043661
75NUAK10.21533464
76CSNK1A10.21289958
77TTK0.20743893
78PLK30.19712770
79ROCK10.17784724
80MAP3K80.17600848
81CHUK0.17407244
82PRKCI0.16524325
83SGK20.16496015
84GRK70.16006895
85EPHA20.15378887
86WNK30.15002748
87FGFR20.14834451
88EIF2AK20.14202844
89ATR0.12138277
90CSNK1G20.12113731
91INSR0.10601198
92PRKCG0.10513708
93PRKCB0.10146764
94GSK3B0.09454871
95PRKAA10.09391434
96CSNK1E0.09213283
97MUSK0.09172874
98ERBB20.08681246
99WNK10.08417692
100MAPKAPK30.07953331

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.85914858
2Fanconi anemia pathway_Homo sapiens_hsa034603.61610995
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.52949387
4Fatty acid degradation_Homo sapiens_hsa000712.52546558
5TGF-beta signaling pathway_Homo sapiens_hsa043502.44939370
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.43511962
7Mineral absorption_Homo sapiens_hsa049782.40992849
8Protein export_Homo sapiens_hsa030602.05038900
9Base excision repair_Homo sapiens_hsa034102.03212246
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93470435
11RNA polymerase_Homo sapiens_hsa030201.93058422
12Caffeine metabolism_Homo sapiens_hsa002321.92890339
13Butanoate metabolism_Homo sapiens_hsa006501.91023115
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87069983
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79463217
16Selenocompound metabolism_Homo sapiens_hsa004501.71906409
17Basal transcription factors_Homo sapiens_hsa030221.71602086
18Linoleic acid metabolism_Homo sapiens_hsa005911.70805766
19Basal cell carcinoma_Homo sapiens_hsa052171.69417025
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69080328
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59684990
22DNA replication_Homo sapiens_hsa030301.58838092
23Lysine degradation_Homo sapiens_hsa003101.55622904
24Fatty acid biosynthesis_Homo sapiens_hsa000611.54541338
25Mismatch repair_Homo sapiens_hsa034301.52054223
26Fatty acid metabolism_Homo sapiens_hsa012121.51000561
27Phototransduction_Homo sapiens_hsa047441.50110219
28Tryptophan metabolism_Homo sapiens_hsa003801.47098123
29Cell cycle_Homo sapiens_hsa041101.45893345
30Hedgehog signaling pathway_Homo sapiens_hsa043401.45500058
31RNA degradation_Homo sapiens_hsa030181.40997205
32Glycerolipid metabolism_Homo sapiens_hsa005611.40990069
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29184671
34Hippo signaling pathway_Homo sapiens_hsa043901.27068546
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23512622
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21959022
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18614789
38Dorso-ventral axis formation_Homo sapiens_hsa043201.12582353
39Non-homologous end-joining_Homo sapiens_hsa034501.08512792
40ABC transporters_Homo sapiens_hsa020101.04762450
41mRNA surveillance pathway_Homo sapiens_hsa030151.02535522
42Peroxisome_Homo sapiens_hsa041461.01051091
43RNA transport_Homo sapiens_hsa030130.98520255
44Purine metabolism_Homo sapiens_hsa002300.95257216
45Nucleotide excision repair_Homo sapiens_hsa034200.93808610
46Nitrogen metabolism_Homo sapiens_hsa009100.93206381
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90952396
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89111546
49Histidine metabolism_Homo sapiens_hsa003400.86127201
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.85352844
51One carbon pool by folate_Homo sapiens_hsa006700.82579672
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80200996
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79747978
54Retinol metabolism_Homo sapiens_hsa008300.78857697
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76207186
56Olfactory transduction_Homo sapiens_hsa047400.75879781
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74124201
58Wnt signaling pathway_Homo sapiens_hsa043100.72223196
59Systemic lupus erythematosus_Homo sapiens_hsa053220.71000197
60Protein digestion and absorption_Homo sapiens_hsa049740.70917127
61Pyrimidine metabolism_Homo sapiens_hsa002400.70686781
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68395031
63PPAR signaling pathway_Homo sapiens_hsa033200.68039900
64N-Glycan biosynthesis_Homo sapiens_hsa005100.65164427
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.63581449
66beta-Alanine metabolism_Homo sapiens_hsa004100.63393934
67Calcium signaling pathway_Homo sapiens_hsa040200.62556426
68Adherens junction_Homo sapiens_hsa045200.61766250
69Arachidonic acid metabolism_Homo sapiens_hsa005900.57791663
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57169593
71Nicotine addiction_Homo sapiens_hsa050330.57031552
72Regulation of autophagy_Homo sapiens_hsa041400.54838807
73Complement and coagulation cascades_Homo sapiens_hsa046100.52967619
74Metabolic pathways_Homo sapiens_hsa011000.48822235
75ECM-receptor interaction_Homo sapiens_hsa045120.47917549
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.47448023
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46336851
78Chemical carcinogenesis_Homo sapiens_hsa052040.46086007
79Ether lipid metabolism_Homo sapiens_hsa005650.45399080
80Hematopoietic cell lineage_Homo sapiens_hsa046400.45333972
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42429597
82Circadian entrainment_Homo sapiens_hsa047130.39657925
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38943726
84Proteasome_Homo sapiens_hsa030500.37696082
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37166989
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36154307
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35846665
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35649817
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34731167
90Glutathione metabolism_Homo sapiens_hsa004800.33482836
91Serotonergic synapse_Homo sapiens_hsa047260.32899682
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30189116
93cAMP signaling pathway_Homo sapiens_hsa040240.30065482
94Oxidative phosphorylation_Homo sapiens_hsa001900.28629774
95Propanoate metabolism_Homo sapiens_hsa006400.27081476
96Inositol phosphate metabolism_Homo sapiens_hsa005620.26690635
97Staphylococcus aureus infection_Homo sapiens_hsa051500.26341652
98Ovarian steroidogenesis_Homo sapiens_hsa049130.25181218
99Thyroid hormone synthesis_Homo sapiens_hsa049180.24704996
100Melanogenesis_Homo sapiens_hsa049160.23921752

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