QRSL1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prenylation (GO:0097354)6.65663555
2protein prenylation (GO:0018342)6.65663555
3mitotic sister chromatid cohesion (GO:0007064)5.65789639
4response to pheromone (GO:0019236)5.31060177
5replication fork processing (GO:0031297)5.21073450
6kinetochore assembly (GO:0051382)5.05292345
7regulation of chromatin silencing (GO:0031935)4.88226852
8kinetochore organization (GO:0051383)4.68145382
9proteasome assembly (GO:0043248)4.25214638
10histone H2A acetylation (GO:0043968)4.24115379
11biotin metabolic process (GO:0006768)4.01035850
12dicarboxylic acid catabolic process (GO:0043649)3.85995401
13retinal rod cell development (GO:0046548)3.83524084
14ether lipid metabolic process (GO:0046485)3.82540757
15interkinetic nuclear migration (GO:0022027)3.67451046
16protein import into peroxisome matrix (GO:0016558)3.61471652
17regulation of centriole replication (GO:0046599)3.61118659
18maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.57707857
19positive regulation of mRNA processing (GO:0050685)3.52146325
20microtubule anchoring (GO:0034453)3.50983949
21histone H3-K36 demethylation (GO:0070544)3.49859353
22sister chromatid cohesion (GO:0007062)3.47321555
23histone mRNA catabolic process (GO:0071044)3.46951232
24retinal cone cell development (GO:0046549)3.36482727
25adaptation of signaling pathway (GO:0023058)3.34155759
26negative regulation of gene expression, epigenetic (GO:0045814)3.29524353
27neurotransmitter uptake (GO:0001504)3.28078292
28ubiquinone biosynthetic process (GO:0006744)3.25547739
29DNA replication-dependent nucleosome assembly (GO:0006335)3.25189739
30DNA replication-dependent nucleosome organization (GO:0034723)3.25189739
31protein K11-linked deubiquitination (GO:0035871)3.20593887
32establishment of protein localization to Golgi (GO:0072600)3.19893727
33amine catabolic process (GO:0009310)3.17325204
34cellular biogenic amine catabolic process (GO:0042402)3.17325204
35melanocyte differentiation (GO:0030318)3.13805798
36negative regulation of DNA-dependent DNA replication (GO:2000104)3.13252010
37Golgi to endosome transport (GO:0006895)3.09851472
38DNA damage induced protein phosphorylation (GO:0006975)3.07083974
39positive regulation of mRNA metabolic process (GO:1903313)3.05912383
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05884916
41histone mRNA metabolic process (GO:0008334)3.03703492
42centriole replication (GO:0007099)3.02816294
43platelet dense granule organization (GO:0060155)3.00331487
44ubiquinone metabolic process (GO:0006743)2.98074623
45negative regulation of axon guidance (GO:1902668)2.96937793
46pigment cell differentiation (GO:0050931)2.96092570
47regulation of protein glycosylation (GO:0060049)2.95294124
48indolalkylamine metabolic process (GO:0006586)2.94808187
49developmental pigmentation (GO:0048066)2.93379429
50negative regulation of DNA recombination (GO:0045910)2.91371140
51cellular response to glucose starvation (GO:0042149)2.90535483
52regulation of gene silencing (GO:0060968)2.90147282
53chromatin silencing (GO:0006342)2.89815729
54reciprocal DNA recombination (GO:0035825)2.87700292
55reciprocal meiotic recombination (GO:0007131)2.87700292
56positive regulation of mRNA 3-end processing (GO:0031442)2.87686496
57response to nitrosative stress (GO:0051409)2.87617184
58regulation of chemokine-mediated signaling pathway (GO:0070099)2.86815992
59DNA double-strand break processing (GO:0000729)2.80459003
60nucleobase biosynthetic process (GO:0046112)2.79642390
61inositol metabolic process (GO:0006020)2.79594589
62negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78727887
63negative regulation of translation, ncRNA-mediated (GO:0040033)2.78727887
64regulation of translation, ncRNA-mediated (GO:0045974)2.78727887
65intraciliary transport (GO:0042073)2.78490819
66cilium or flagellum-dependent cell motility (GO:0001539)2.76470913
67replicative senescence (GO:0090399)2.76180335
68negative regulation of alpha-beta T cell differentiation (GO:0046639)2.74476663
69nucleotide-excision repair, DNA gap filling (GO:0006297)2.74329446
70protein localization to peroxisome (GO:0072662)2.72139265
71protein targeting to peroxisome (GO:0006625)2.72139265
72establishment of protein localization to peroxisome (GO:0072663)2.72139265
73nodal signaling pathway (GO:0038092)2.70211046
74regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.69573087
75histone-serine phosphorylation (GO:0035404)2.68719399
76pericardium development (GO:0060039)2.68643681
77protein localization to microtubule cytoskeleton (GO:0072698)2.68424986
78regulation of mRNA 3-end processing (GO:0031440)2.66402411
79quinone biosynthetic process (GO:1901663)2.66035245
80protein targeting to Golgi (GO:0000042)2.65770073
81regulation of establishment of cell polarity (GO:2000114)2.64824937
82retrograde transport, vesicle recycling within Golgi (GO:0000301)2.63393099
83regulation of sister chromatid cohesion (GO:0007063)2.63261052
84positive regulation of glycoprotein biosynthetic process (GO:0010560)2.61765977
85fibroblast migration (GO:0010761)2.61182311
86cytoplasmic mRNA processing body assembly (GO:0033962)2.60602089
87photoreceptor cell maintenance (GO:0045494)2.59602474
88recombinational repair (GO:0000725)2.58369937
89purine-containing compound salvage (GO:0043101)2.57579901
90double-strand break repair via homologous recombination (GO:0000724)2.56931647
91purine nucleobase biosynthetic process (GO:0009113)2.55973940
92neuronal stem cell maintenance (GO:0097150)2.54584493
93cellular response to sterol (GO:0036315)2.53435550
94negative regulation of leukocyte chemotaxis (GO:0002689)2.51619884
95arginine catabolic process (GO:0006527)2.49957815
96neuroepithelial cell differentiation (GO:0060563)2.48583358
97eye photoreceptor cell development (GO:0042462)2.48022053
98glutamine family amino acid catabolic process (GO:0009065)2.46525557
99protein sumoylation (GO:0016925)2.46056905
100branched-chain amino acid catabolic process (GO:0009083)2.45233288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.74898276
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.57743717
3TAF15_26573619_Chip-Seq_HEK293_Human3.38950619
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12259756
5IGF1R_20145208_ChIP-Seq_DFB_Human3.02318256
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70715479
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.64656428
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47101066
9E2F7_22180533_ChIP-Seq_HELA_Human2.46020091
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44066656
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.38679699
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23822901
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.20849271
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13909735
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.07870508
16FUS_26573619_Chip-Seq_HEK293_Human2.03973426
17GBX2_23144817_ChIP-Seq_PC3_Human1.96525304
18E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95094751
19EWS_26573619_Chip-Seq_HEK293_Human1.94487759
20IRF1_19129219_ChIP-ChIP_H3396_Human1.94252286
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86083910
22EZH2_27294783_Chip-Seq_NPCs_Mouse1.85332154
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85020978
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.79190998
25CBP_20019798_ChIP-Seq_JUKART_Human1.79190998
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.76386431
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73437892
28P300_19829295_ChIP-Seq_ESCs_Human1.71487453
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.71193650
30SMAD4_21799915_ChIP-Seq_A2780_Human1.68257507
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67024607
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65097818
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56486408
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55660994
35STAT3_23295773_ChIP-Seq_U87_Human1.54532131
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53742409
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50098927
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48339827
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47462668
40VDR_23849224_ChIP-Seq_CD4+_Human1.46718069
41ELK1_19687146_ChIP-ChIP_HELA_Human1.44695091
42TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43027983
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42651677
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42058735
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40964447
46CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38063009
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36208640
48ER_23166858_ChIP-Seq_MCF-7_Human1.35006103
49CRX_20693478_ChIP-Seq_RETINA_Mouse1.34176634
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32565619
51P53_22387025_ChIP-Seq_ESCs_Mouse1.32501288
52AR_21572438_ChIP-Seq_LNCaP_Human1.32338700
53GATA1_22025678_ChIP-Seq_K562_Human1.30306506
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29970632
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29451115
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.29241458
57TCF4_23295773_ChIP-Seq_U87_Human1.28457586
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27452580
59VDR_22108803_ChIP-Seq_LS180_Human1.27419364
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26900577
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.25509225
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25379597
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25351059
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.24583270
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.23595516
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23307909
67TP53_16413492_ChIP-PET_HCT116_Human1.22972879
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22739921
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20831130
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.18765136
71OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17831575
72MYC_18940864_ChIP-ChIP_HL60_Human1.17588753
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16089972
74RUNX_20019798_ChIP-Seq_JUKART_Human1.15788602
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.14461920
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13324410
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13324410
78NANOG_19829295_ChIP-Seq_ESCs_Human1.11512575
79SOX2_19829295_ChIP-Seq_ESCs_Human1.11512575
80CDX2_22108803_ChIP-Seq_LS180_Human1.11142220
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10646108
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08990794
83AR_25329375_ChIP-Seq_VCAP_Human1.08717324
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06777375
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06111960
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05616580
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05576903
88AHR_22903824_ChIP-Seq_MCF-7_Human1.04295057
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.03679660
90P300_18555785_Chip-Seq_ESCs_Mouse1.02964541
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02639030
92BCAT_22108803_ChIP-Seq_LS180_Human1.02590777
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01882082
94SALL4_22934838_ChIP-ChIP_CD34+_Human1.00219315
95SOX2_18555785_Chip-Seq_ESCs_Mouse0.99475414
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99225910
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.98977597
98SMAD_19615063_ChIP-ChIP_OVARY_Human0.97838727
99CMYC_18555785_Chip-Seq_ESCs_Mouse0.97578015
100TCF4_22108803_ChIP-Seq_LS180_Human0.96834295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation5.72704855
2MP0000372_irregular_coat_pigmentation4.40835348
3MP0005174_abnormal_tail_pigmentation4.01129032
4MP0008057_abnormal_DNA_replication3.69969587
5MP0000015_abnormal_ear_pigmentation3.45355021
6MP0000569_abnormal_digit_pigmentation2.99234085
7MP0002938_white_spotting2.84821818
8MP0002095_abnormal_skin_pigmentation2.78895644
9MP0003136_yellow_coat_color2.66828193
10MP0003195_calcinosis2.65723125
11MP0005075_abnormal_melanosome_morpholog2.53515751
12MP0010094_abnormal_chromosome_stability2.37838643
13MP0005253_abnormal_eye_physiology2.37240897
14MP0008877_abnormal_DNA_methylation2.33110611
15MP0008789_abnormal_olfactory_epithelium2.25701426
16MP0000371_diluted_coat_color2.22253156
17MP0000383_abnormal_hair_follicle2.15449335
18MP0004381_abnormal_hair_follicle2.13764466
19MP0009697_abnormal_copulation2.12996238
20MP0002638_abnormal_pupillary_reflex2.00214537
21MP0004147_increased_porphyrin_level1.94363901
22MP0005645_abnormal_hypothalamus_physiol1.93572033
23MP0008058_abnormal_DNA_repair1.93355440
24MP0002075_abnormal_coat/hair_pigmentati1.73429131
25MP0002163_abnormal_gland_morphology1.63795441
26MP0002653_abnormal_ependyma_morphology1.62213335
27MP0005394_taste/olfaction_phenotype1.55217330
28MP0005499_abnormal_olfactory_system1.55217330
29MP0005248_abnormal_Harderian_gland1.54142931
30MP0006072_abnormal_retinal_apoptosis1.53251160
31MP0005670_abnormal_white_adipose1.50905460
32MP0005408_hypopigmentation1.49368089
33MP0004142_abnormal_muscle_tone1.48409279
34MP0003045_fibrosis1.45584781
35MP0005379_endocrine/exocrine_gland_phen1.37389146
36MP0005310_abnormal_salivary_gland1.30343488
37MP0003121_genomic_imprinting1.28763392
38MP0002168_other_aberrant_phenotype1.28331698
39MP0002751_abnormal_autonomic_nervous1.24715501
40MP0001188_hyperpigmentation1.20656863
41MP0005551_abnormal_eye_electrophysiolog1.20180810
42MP0002177_abnormal_outer_ear1.18593169
43MP0003880_abnormal_central_pattern1.15550000
44MP0002102_abnormal_ear_morphology1.15337939
45MP0010678_abnormal_skin_adnexa1.13043830
46MP0006276_abnormal_autonomic_nervous1.11058783
47MP0009046_muscle_twitch1.10246453
48MP0006292_abnormal_olfactory_placode1.09317494
49MP0002876_abnormal_thyroid_physiology1.08019055
50MP0001324_abnormal_eye_pigmentation1.05151293
51MP0002837_dystrophic_cardiac_calcinosis1.04882480
52MP0005391_vision/eye_phenotype1.04447598
53MP0002234_abnormal_pharynx_morphology1.02189079
54MP0005367_renal/urinary_system_phenotyp1.01450915
55MP0000516_abnormal_urinary_system1.01450915
56MP0000427_abnormal_hair_cycle0.99172568
57MP0001186_pigmentation_phenotype0.98255548
58MP0004145_abnormal_muscle_electrophysio0.97651496
59MP0003252_abnormal_bile_duct0.95173090
60MP0003646_muscle_fatigue0.92330383
61MP0008932_abnormal_embryonic_tissue0.91068073
62MP0001293_anophthalmia0.88591441
63MP0005266_abnormal_metabolism0.85019895
64MP0003077_abnormal_cell_cycle0.83055841
65MP0000631_abnormal_neuroendocrine_gland0.82943461
66MP0005332_abnormal_amino_acid0.82735609
67MP0004134_abnormal_chest_morphology0.82607294
68MP0003763_abnormal_thymus_physiology0.81426512
69MP0003122_maternal_imprinting0.80132123
70MP0002127_abnormal_cardiovascular_syste0.78218366
71MP0003693_abnormal_embryo_hatching0.77844505
72MP0003890_abnormal_embryonic-extraembry0.77146881
73MP0000639_abnormal_adrenal_gland0.76650364
74MP0001765_abnormal_ion_homeostasis0.75835545
75MP0002090_abnormal_vision0.73522177
76MP0004215_abnormal_myocardial_fiber0.71656507
77MP0001485_abnormal_pinna_reflex0.70725200
78MP0003183_abnormal_peptide_metabolism0.70222708
79MP0001299_abnormal_eye_distance/0.67372433
80MP0002233_abnormal_nose_morphology0.66190869
81MP0005646_abnormal_pituitary_gland0.65672519
82MP0005395_other_phenotype0.65190417
83MP0009703_decreased_birth_body0.63553383
84MP0000358_abnormal_cell_content/0.62910575
85MP0002928_abnormal_bile_duct0.61991425
86MP0003787_abnormal_imprinting0.61305991
87MP0001502_abnormal_circadian_rhythm0.59796495
88MP0003315_abnormal_perineum_morphology0.59492581
89MP0000681_abnormal_thyroid_gland0.58771628
90MP0001984_abnormal_olfaction0.58284208
91MP0003111_abnormal_nucleus_morphology0.56653339
92MP0005195_abnormal_posterior_eye0.56589837
93MP0002332_abnormal_exercise_endurance0.56547878
94MP0008961_abnormal_basal_metabolism0.54368477
95MP0002067_abnormal_sensory_capabilities0.53886801
96MP0002229_neurodegeneration0.53763380
97MP0006138_congestive_heart_failure0.53477924
98MP0002069_abnormal_eating/drinking_beha0.52792926
99MP0001929_abnormal_gametogenesis0.52768292
100MP0008775_abnormal_heart_ventricle0.52386806

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)4.18902048
2Hypoplasia of the thymus (HP:0000778)3.60076282
3Hypoplastic ischia (HP:0003175)3.56660395
4Albinism (HP:0001022)3.52020321
5White forelock (HP:0002211)3.48749483
6Abnormality of the renal cortex (HP:0011035)3.47599537
7Long clavicles (HP:0000890)3.11355077
8Diastasis recti (HP:0001540)3.10018597
9Genetic anticipation (HP:0003743)3.09767716
10Patchy hypopigmentation of hair (HP:0011365)3.08860772
11Hyperventilation (HP:0002883)3.06264176
12Abnormality of the ischium (HP:0003174)3.02208192
13Volvulus (HP:0002580)2.88177798
14Attenuation of retinal blood vessels (HP:0007843)2.86584507
15Tubulointerstitial nephritis (HP:0001970)2.71181794
16Absent rod-and cone-mediated responses on ERG (HP:0007688)2.64684999
17Aplasia/Hypoplasia of the tongue (HP:0010295)2.59964011
18Hypothermia (HP:0002045)2.57481466
19Pancreatic cysts (HP:0001737)2.55374572
20Central scotoma (HP:0000603)2.54228415
21Rhabdomyosarcoma (HP:0002859)2.51870560
22Blue irides (HP:0000635)2.51004280
23Cone-rod dystrophy (HP:0000548)2.50737775
24Thyroiditis (HP:0100646)2.49670500
25Panhypogammaglobulinemia (HP:0003139)2.47186679
26Hypoplasia of the fovea (HP:0007750)2.46510654
27Aplasia/Hypoplasia of the fovea (HP:0008060)2.46510654
28Congenital sensorineural hearing impairment (HP:0008527)2.46097728
29CNS hypomyelination (HP:0003429)2.43712031
30Supernumerary spleens (HP:0009799)2.43486152
31Abnormal rod and cone electroretinograms (HP:0008323)2.41877903
32Glioma (HP:0009733)2.41632503
33Pancreatic fibrosis (HP:0100732)2.40830450
34Severe combined immunodeficiency (HP:0004430)2.39139114
35Hypoplastic iliac wings (HP:0002866)2.38412461
36Chronic hepatic failure (HP:0100626)2.38310899
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.37403173
38Medial flaring of the eyebrow (HP:0010747)2.36927552
39Neoplasm of the adrenal gland (HP:0100631)2.35111747
40True hermaphroditism (HP:0010459)2.32683339
41Constricted visual fields (HP:0001133)2.32252084
42Birth length less than 3rd percentile (HP:0003561)2.29578461
43Decreased central vision (HP:0007663)2.28168632
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.27810221
45Severe global developmental delay (HP:0011344)2.27660077
46B lymphocytopenia (HP:0010976)2.24842591
47Abnormality of the labia minora (HP:0012880)2.24575220
48Neoplasm of the adrenal cortex (HP:0100641)2.24254964
49Abnormality of B cell number (HP:0010975)2.23557417
50Abnormality of chromosome stability (HP:0003220)2.22321033
51Fibular aplasia (HP:0002990)2.22076271
52Congenital primary aphakia (HP:0007707)2.19496953
53Abnormality of the fovea (HP:0000493)2.18647165
54Stomach cancer (HP:0012126)2.10972536
55Absence seizures (HP:0002121)2.09817319
56Papillary thyroid carcinoma (HP:0002895)2.07303342
57Tented upper lip vermilion (HP:0010804)2.06223421
58Microglossia (HP:0000171)2.05888332
59Hypoplastic scapulae (HP:0000882)2.04634189
60Aplasia/Hypoplasia of the scapulae (HP:0006713)2.04634189
61Ectopic kidney (HP:0000086)2.03422038
62Gait imbalance (HP:0002141)2.02665238
63Large earlobe (HP:0009748)2.01807541
64Congenital stationary night blindness (HP:0007642)1.98606424
65Abnormality of the renal medulla (HP:0100957)1.98498092
66Mesangial abnormality (HP:0001966)1.95309584
67Postaxial foot polydactyly (HP:0001830)1.94831714
68Neoplasm of the peripheral nervous system (HP:0100007)1.92046989
69Broad foot (HP:0001769)1.87825160
70Abnormality of the pubic bones (HP:0003172)1.87610984
71Papilledema (HP:0001085)1.86602528
72Bony spicule pigmentary retinopathy (HP:0007737)1.85602281
73Astrocytoma (HP:0009592)1.84156369
74Abnormality of the astrocytes (HP:0100707)1.84156369
75Recurrent bronchitis (HP:0002837)1.84086281
76Nephrogenic diabetes insipidus (HP:0009806)1.83970238
77Asplenia (HP:0001746)1.83330476
78Astigmatism (HP:0000483)1.83117803
79Dialeptic seizures (HP:0011146)1.82838116
80Abnormality of eosinophils (HP:0001879)1.81221516
81Nephronophthisis (HP:0000090)1.80640960
82Aplasia/Hypoplasia of the spleen (HP:0010451)1.80297006
83Combined immunodeficiency (HP:0005387)1.80020153
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.79053177
85Autoimmune hemolytic anemia (HP:0001890)1.78465309
86Fair hair (HP:0002286)1.78385830
87Poor coordination (HP:0002370)1.76834451
88Hypoplasia of the iris (HP:0007676)1.75416048
89Genital tract atresia (HP:0001827)1.74900889
90Clitoromegaly (HP:0000057)1.73770648
91Sloping forehead (HP:0000340)1.71207422
92Molar tooth sign on MRI (HP:0002419)1.71014942
93Abnormality of midbrain morphology (HP:0002418)1.71014942
94Generalized hypopigmentation of hair (HP:0011358)1.69914299
95Gaze-evoked nystagmus (HP:0000640)1.69142420
96Cystic hygroma (HP:0000476)1.66926250
97Acute myeloid leukemia (HP:0004808)1.66020034
98Absent/shortened dynein arms (HP:0200106)1.65400356
99Dynein arm defect of respiratory motile cilia (HP:0012255)1.65400356
100Ependymoma (HP:0002888)1.65129575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.38795694
2ZAK4.25537974
3MAP4K23.62168780
4BRSK23.51766807
5BMPR1B3.16841718
6EPHA32.87923245
7TNIK2.72694640
8NLK2.58766004
9AKT32.53331031
10ACVR1B2.53184621
11MARK31.97104320
12NUAK11.91018417
13FER1.84468022
14MKNK21.82637055
15EIF2AK11.82512812
16STK391.82314790
17CDC71.65967607
18CCNB11.47880835
19PLK31.46543299
20BCKDK1.41279939
21MKNK11.40851534
22WNK31.38689406
23IRAK11.28878719
24OBSCN1.27811196
25PAK31.19504587
26TEC1.19239940
27TXK1.18917045
28CAMKK21.14582260
29ERBB31.12962966
30PLK41.12562100
31KIT1.06606142
32TRIM281.01914561
33VRK11.01876547
34BRD41.01514116
35CAMK1D1.01463042
36WNK41.01127373
37CAMK1G1.00808545
38ATR0.95234919
39EPHA40.94408980
40MAPK130.92104801
41TAOK30.91995316
42GRK10.91881366
43SRPK10.90893691
44SGK20.89331211
45TTK0.88535116
46BCR0.85965323
47PLK20.85092507
48BRSK10.83545688
49EIF2AK30.83435379
50RPS6KA40.81916545
51CDK120.81021183
52FLT30.75715857
53WNK10.75252539
54CHEK20.73328262
55ATM0.72830864
56BUB10.70265908
57CDK80.69834264
58WEE10.69565093
59PRKCE0.66846835
60CDK30.65500137
61KSR10.64508874
62DYRK30.64110288
63MELK0.62403089
64EIF2AK20.60903706
65MST40.59229333
66DYRK1A0.54287862
67TRPM70.52644209
68OXSR10.51885029
69MAP3K40.51245862
70SIK30.50737844
71GRK70.49481107
72PAK60.49202617
73STK38L0.47344130
74CAMK40.45709658
75TGFBR10.45484385
76FGFR10.44822469
77MATK0.44611660
78TGFBR20.42915613
79TLK10.40444663
80MAPKAPK50.40297090
81ITK0.39467203
82RPS6KA50.39121840
83CAMK10.38374945
84JAK10.37878806
85PIM10.36736079
86PKN10.36170335
87PRKAA20.34965421
88NEK60.34357058
89CHEK10.33857638
90NEK90.32651990
91JAK20.32062633
92PLK10.31234334
93PRKACB0.31108593
94PTK2B0.31098191
95SGK4940.30198082
96SGK2230.30198082
97PIK3CA0.30044875
98MAPK80.29298843
99ABL10.28857965
100INSRR0.28462270

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.56688336
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.22519738
3Propanoate metabolism_Homo sapiens_hsa006403.15543619
4Non-homologous end-joining_Homo sapiens_hsa034503.03886655
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.91146160
6Fanconi anemia pathway_Homo sapiens_hsa034602.85745260
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72648550
8Homologous recombination_Homo sapiens_hsa034402.72245749
9Butanoate metabolism_Homo sapiens_hsa006502.48864001
10RNA polymerase_Homo sapiens_hsa030202.29306291
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17883953
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07632658
13Peroxisome_Homo sapiens_hsa041462.04224189
14Arginine biosynthesis_Homo sapiens_hsa002202.03534297
15Lysine degradation_Homo sapiens_hsa003102.02332421
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93403380
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.86634814
18Mismatch repair_Homo sapiens_hsa034301.86616963
19Proteasome_Homo sapiens_hsa030501.79618072
20Protein export_Homo sapiens_hsa030601.75895462
21RNA degradation_Homo sapiens_hsa030181.70440111
22DNA replication_Homo sapiens_hsa030301.70407697
23Circadian rhythm_Homo sapiens_hsa047101.53026790
24Fatty acid elongation_Homo sapiens_hsa000621.52284362
25ABC transporters_Homo sapiens_hsa020101.48434426
26One carbon pool by folate_Homo sapiens_hsa006701.47097259
27Tryptophan metabolism_Homo sapiens_hsa003801.41855127
28Regulation of autophagy_Homo sapiens_hsa041401.32154401
29Fatty acid metabolism_Homo sapiens_hsa012121.15967220
30Cell cycle_Homo sapiens_hsa041101.13409313
31Spliceosome_Homo sapiens_hsa030401.10678377
32Primary immunodeficiency_Homo sapiens_hsa053401.09448010
33Steroid biosynthesis_Homo sapiens_hsa001001.05636222
34Purine metabolism_Homo sapiens_hsa002301.04457506
35Linoleic acid metabolism_Homo sapiens_hsa005911.00536732
36Phototransduction_Homo sapiens_hsa047440.98003279
37Arachidonic acid metabolism_Homo sapiens_hsa005900.95293019
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90599906
39Maturity onset diabetes of the young_Homo sapiens_hsa049500.88688203
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87462150
41Olfactory transduction_Homo sapiens_hsa047400.85560123
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85102703
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.84633970
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83588595
45RNA transport_Homo sapiens_hsa030130.81637781
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80445066
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79643321
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78945698
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78795043
50Fatty acid degradation_Homo sapiens_hsa000710.78541095
51beta-Alanine metabolism_Homo sapiens_hsa004100.76546350
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74948899
53Folate biosynthesis_Homo sapiens_hsa007900.71898400
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66791778
55mRNA surveillance pathway_Homo sapiens_hsa030150.66603304
56Pyruvate metabolism_Homo sapiens_hsa006200.64164615
57Glutamatergic synapse_Homo sapiens_hsa047240.63905965
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63547112
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63124640
60Taste transduction_Homo sapiens_hsa047420.62762210
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61931415
62Histidine metabolism_Homo sapiens_hsa003400.60422330
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58376249
64Pyrimidine metabolism_Homo sapiens_hsa002400.56566506
65Oocyte meiosis_Homo sapiens_hsa041140.53864969
66Selenocompound metabolism_Homo sapiens_hsa004500.52750943
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52632216
68Serotonergic synapse_Homo sapiens_hsa047260.50656405
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49128978
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47701511
71Renin secretion_Homo sapiens_hsa049240.47666359
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46982853
73Biosynthesis of amino acids_Homo sapiens_hsa012300.46914538
74Metabolic pathways_Homo sapiens_hsa011000.45513729
75Basal transcription factors_Homo sapiens_hsa030220.44975684
76Base excision repair_Homo sapiens_hsa034100.44534090
77Ether lipid metabolism_Homo sapiens_hsa005650.43168630
78TGF-beta signaling pathway_Homo sapiens_hsa043500.40943054
79p53 signaling pathway_Homo sapiens_hsa041150.40777465
80GABAergic synapse_Homo sapiens_hsa047270.40477481
81Alcoholism_Homo sapiens_hsa050340.39936537
82Sulfur relay system_Homo sapiens_hsa041220.39915510
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.36642542
84Chemical carcinogenesis_Homo sapiens_hsa052040.36629851
85Ovarian steroidogenesis_Homo sapiens_hsa049130.36123813
86Hematopoietic cell lineage_Homo sapiens_hsa046400.35164098
87Calcium signaling pathway_Homo sapiens_hsa040200.34935261
88Carbon metabolism_Homo sapiens_hsa012000.34766760
89Type I diabetes mellitus_Homo sapiens_hsa049400.34507807
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34244865
91Glycerolipid metabolism_Homo sapiens_hsa005610.28098491
92Glutathione metabolism_Homo sapiens_hsa004800.25959089
93Inositol phosphate metabolism_Homo sapiens_hsa005620.25859564
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24349463
95Notch signaling pathway_Homo sapiens_hsa043300.24268883
96FoxO signaling pathway_Homo sapiens_hsa040680.23984673
97Colorectal cancer_Homo sapiens_hsa052100.22879941
98Legionellosis_Homo sapiens_hsa051340.21205453
99Glucagon signaling pathway_Homo sapiens_hsa049220.20597560
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.20086644

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