QSOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.55528849
2L-phenylalanine catabolic process (GO:0006559)6.55528849
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.32868813
4L-phenylalanine metabolic process (GO:0006558)6.32868813
5negative regulation of fibrinolysis (GO:0051918)5.76083778
6aromatic amino acid family catabolic process (GO:0009074)5.74509206
7sulfur amino acid catabolic process (GO:0000098)5.50834801
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.50374665
9alpha-linolenic acid metabolic process (GO:0036109)5.46856004
10regulation of fibrinolysis (GO:0051917)5.36000427
11cysteine metabolic process (GO:0006534)5.34984168
12type B pancreatic cell proliferation (GO:0044342)5.29958863
13protein carboxylation (GO:0018214)5.15728722
14peptidyl-glutamic acid carboxylation (GO:0017187)5.15728722
15complement activation, alternative pathway (GO:0006957)5.15437933
16tryptophan catabolic process (GO:0006569)5.12754640
17indole-containing compound catabolic process (GO:0042436)5.12754640
18indolalkylamine catabolic process (GO:0046218)5.12754640
19regulation of protein activation cascade (GO:2000257)5.10581996
20bile acid biosynthetic process (GO:0006699)5.09442794
21kynurenine metabolic process (GO:0070189)5.09167040
22urea metabolic process (GO:0019627)5.05450876
23urea cycle (GO:0000050)5.05450876
24high-density lipoprotein particle remodeling (GO:0034375)4.99729668
25skin morphogenesis (GO:0043589)4.98338717
26glyoxylate metabolic process (GO:0046487)4.88214767
27tryptophan metabolic process (GO:0006568)4.85551544
28regulation of complement activation (GO:0030449)4.79876909
29nitrogen cycle metabolic process (GO:0071941)4.65376395
30serine family amino acid catabolic process (GO:0009071)4.63020546
31reverse cholesterol transport (GO:0043691)4.52606295
32regulation of triglyceride catabolic process (GO:0010896)4.51344326
33homocysteine metabolic process (GO:0050667)4.48408981
34protein heterotrimerization (GO:0070208)4.42465887
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.39669202
36endodermal cell differentiation (GO:0035987)4.37702288
37bile acid metabolic process (GO:0008206)4.32342737
38adhesion of symbiont to host cell (GO:0044650)4.28985792
39virion attachment to host cell (GO:0019062)4.28985792
40plasma lipoprotein particle remodeling (GO:0034369)4.25529859
41protein-lipid complex remodeling (GO:0034368)4.25529859
42macromolecular complex remodeling (GO:0034367)4.25529859
43triglyceride homeostasis (GO:0070328)4.18793299
44acylglycerol homeostasis (GO:0055090)4.18793299
45phospholipid efflux (GO:0033700)4.18755961
46extracellular matrix assembly (GO:0085029)4.16600376
47regulation of cholesterol esterification (GO:0010872)4.16504072
48aromatic amino acid family metabolic process (GO:0009072)4.15173534
49bone trabecula formation (GO:0060346)4.11425053
50regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.11209510
51amino-acid betaine metabolic process (GO:0006577)4.07346403
52plasma lipoprotein particle clearance (GO:0034381)4.06952919
53lysine metabolic process (GO:0006553)4.06779310
54lysine catabolic process (GO:0006554)4.06779310
55tyrosine metabolic process (GO:0006570)4.05685729
56sequestering of extracellular ligand from receptor (GO:0035581)4.05433698
57fibrinolysis (GO:0042730)4.01176063
58alpha-amino acid catabolic process (GO:1901606)4.00833563
59cellular modified amino acid catabolic process (GO:0042219)3.98382880
60ethanol oxidation (GO:0006069)3.95232467
61Golgi transport vesicle coating (GO:0048200)3.94327823
62COPI coating of Golgi vesicle (GO:0048205)3.94327823
63coenzyme catabolic process (GO:0009109)3.88798146
64regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.86791250
65adhesion of symbiont to host (GO:0044406)3.85244678
66cell adhesion mediated by integrin (GO:0033627)3.84489150
67regulation of plasminogen activation (GO:0010755)3.83919871
68protein localization to endosome (GO:0036010)3.83560467
69barbed-end actin filament capping (GO:0051016)3.83150970
70negative regulation of sterol transport (GO:0032372)3.82333934
71negative regulation of cholesterol transport (GO:0032375)3.82333934
72bile acid and bile salt transport (GO:0015721)3.81637273
73glycine metabolic process (GO:0006544)3.81582479
74cellular amino acid catabolic process (GO:0009063)3.78560748
75negative regulation of lipase activity (GO:0060192)3.77196401
76maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.76464312
77intestinal cholesterol absorption (GO:0030299)3.76414861
78kidney mesenchyme development (GO:0072074)3.75703183
79cholesterol efflux (GO:0033344)3.75612696
80protein retention in ER lumen (GO:0006621)3.75559966
81extracellular fibril organization (GO:0043206)3.75068442
82blood vessel maturation (GO:0001955)3.73763503
83serine family amino acid metabolic process (GO:0009069)3.72991679
84positive regulation of triglyceride lipase activity (GO:0061365)3.72539057
85positive regulation of lipoprotein lipase activity (GO:0051006)3.72539057
86collagen fibril organization (GO:0030199)3.70070646
87glutamate metabolic process (GO:0006536)3.66452803
88acute-phase response (GO:0006953)3.63834817
89epoxygenase P450 pathway (GO:0019373)3.63160615
90hemidesmosome assembly (GO:0031581)3.61531988
91cell migration involved in heart development (GO:0060973)3.61417612
92indolalkylamine metabolic process (GO:0006586)3.60206518
93apoptotic cell clearance (GO:0043277)3.58360629
94lung vasculature development (GO:0060426)3.57371398
95regulation of cholesterol homeostasis (GO:2000188)3.56813043
96plasma lipoprotein particle assembly (GO:0034377)3.56728814
97imidazole-containing compound metabolic process (GO:0052803)3.56004992
98cellular glucuronidation (GO:0052695)3.55993953
99cellular biogenic amine catabolic process (GO:0042402)3.53501995
100amine catabolic process (GO:0009310)3.53501995
101phospholipid homeostasis (GO:0055091)3.53015657
102respiratory tube development (GO:0030323)3.52725141
103cellular ketone body metabolic process (GO:0046950)3.52693056
104arginine metabolic process (GO:0006525)3.52637926
105opsonization (GO:0008228)3.52197658
106benzene-containing compound metabolic process (GO:0042537)3.51951420
107positive regulation of lipid catabolic process (GO:0050996)3.51951083
108mesenchymal cell differentiation involved in kidney development (GO:0072161)3.50368860
109mesenchymal cell differentiation involved in renal system development (GO:2001012)3.50368860
110fibril organization (GO:0097435)3.49451373
111chondrocyte proliferation (GO:0035988)3.49434069
112serine family amino acid biosynthetic process (GO:0009070)3.48729553
113peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.48060983
114complement activation, classical pathway (GO:0006958)3.46271699
115planar cell polarity pathway involved in neural tube closure (GO:0090179)3.46267304
116cholesterol homeostasis (GO:0042632)3.45750030
117complement activation (GO:0006956)3.45514289
118basement membrane organization (GO:0071711)3.43833991
119vascular endothelial growth factor signaling pathway (GO:0038084)3.41982564
120protein activation cascade (GO:0072376)3.41817159
121positive regulation of fatty acid beta-oxidation (GO:0032000)3.41730915
122sterol homeostasis (GO:0055092)3.40999751
123negative regulation of protein activation cascade (GO:2000258)3.39800002
124collagen metabolic process (GO:0032963)3.39253654
125negative regulation of smooth muscle cell migration (GO:0014912)3.36443556
126linoleic acid metabolic process (GO:0043651)3.34974751
127cytolysis (GO:0019835)3.34211009
128lipoprotein metabolic process (GO:0042157)3.33499633
129acetyl-CoA metabolic process (GO:0006084)3.33206314
130organic acid catabolic process (GO:0016054)3.32972877
131carboxylic acid catabolic process (GO:0046395)3.32972877
132metanephric mesenchyme development (GO:0072075)3.31822815
133blood coagulation, intrinsic pathway (GO:0007597)3.31364554
134valine metabolic process (GO:0006573)3.31007134
135cell-substrate junction assembly (GO:0007044)3.30449325
136heme transport (GO:0015886)3.30348358
137plasma lipoprotein particle organization (GO:0071827)3.29843175
138positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.29697423
139aldehyde catabolic process (GO:0046185)3.28373486
140protein-lipid complex assembly (GO:0065005)3.27878716
141cofactor catabolic process (GO:0051187)3.27065256
142positive regulation of endothelial cell apoptotic process (GO:2000353)3.27039807
143hypotonic response (GO:0006971)3.26362921
144collagen catabolic process (GO:0030574)3.24575058
145extracellular matrix disassembly (GO:0022617)3.21887980
146stress fiber assembly (GO:0043149)3.19661106
147regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.18115581
148multicellular organismal macromolecule metabolic process (GO:0044259)3.14666211
149pinocytosis (GO:0006907)3.13902657
150dermatan sulfate metabolic process (GO:0030205)3.13358026
151regulation of early endosome to late endosome transport (GO:2000641)3.12383071
152hyaluronan catabolic process (GO:0030214)3.11349649
153embryo implantation (GO:0007566)3.11137679
154keratan sulfate catabolic process (GO:0042340)3.09655717
155cellular response to vitamin (GO:0071295)3.07457171
156endocardial cushion development (GO:0003197)3.05875944
157positive regulation of blood vessel endothelial cell migration (GO:0043536)3.02797270
158regulation of extracellular matrix disassembly (GO:0010715)3.01886669
159regulation of response to osmotic stress (GO:0047484)3.01602216
160dermatan sulfate biosynthetic process (GO:0030208)3.00956192
161multicellular organismal catabolic process (GO:0044243)2.99417688
162substrate-dependent cell migration (GO:0006929)2.98132544
163negative regulation of chondrocyte differentiation (GO:0032331)2.95371936
164multicellular organismal metabolic process (GO:0044236)2.94859070
165positive regulation of extracellular matrix organization (GO:1903055)2.93384003
166mesenchymal-epithelial cell signaling (GO:0060638)2.92661999
167positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.92004823
168venous blood vessel morphogenesis (GO:0048845)2.90460598
169chondroitin sulfate biosynthetic process (GO:0030206)2.89555451
170regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.89211361
171wound healing, spreading of epidermal cells (GO:0035313)2.88895756
172dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.84899499
173heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.80882580
174adherens junction assembly (GO:0034333)2.80126334
175vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.78929700
176positive regulation of receptor recycling (GO:0001921)2.77793228
177peptidyl-proline hydroxylation (GO:0019511)2.77250963
178mannose metabolic process (GO:0006013)2.77014586
179extracellular matrix organization (GO:0030198)2.75270474
180extracellular structure organization (GO:0043062)2.74175363
181tooth mineralization (GO:0034505)2.73198298
182negative regulation of osteoblast proliferation (GO:0033689)2.71230586
183chondroitin sulfate catabolic process (GO:0030207)2.71074751
184regulation of collagen metabolic process (GO:0010712)2.68930765
185mesodermal cell differentiation (GO:0048333)2.68887456
186UV protection (GO:0009650)2.68201778
187diaphragm development (GO:0060539)2.68199654
188cell-substrate adherens junction assembly (GO:0007045)2.68088468
189focal adhesion assembly (GO:0048041)2.68088468
190cortical actin cytoskeleton organization (GO:0030866)2.67956671
191extracellular regulation of signal transduction (GO:1900115)2.67396416
192extracellular negative regulation of signal transduction (GO:1900116)2.67396416
193glial cell migration (GO:0008347)2.65483097
194protein hydroxylation (GO:0018126)2.65447631
195epithelial cell-cell adhesion (GO:0090136)2.64364723
196desmosome organization (GO:0002934)2.61860823
197endocytic recycling (GO:0032456)2.61541897
198establishment of apical/basal cell polarity (GO:0035089)2.59540273
199regulation of membrane protein ectodomain proteolysis (GO:0051043)2.59059017
200surfactant homeostasis (GO:0043129)2.56607903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.20765716
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.26886235
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.72658852
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.57739258
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.14792753
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.53297624
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.23633637
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.66099225
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.15657544
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.58015644
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.55500622
12CLOCK_20551151_ChIP-Seq_293T_Human2.45190033
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35136212
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.01608948
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2522384
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99182809
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.97127450
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92562252
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92006137
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90678968
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84212368
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83526333
23P300_27058665_Chip-Seq_ZR-75-30cells_Human1.79060964
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.77942440
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.76910122
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.74528296
27UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.68298794
28TP53_22127205_ChIP-Seq_IMR90_Human1.65747036
29* ESR2_21235772_ChIP-Seq_MCF-7_Human1.60051524
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56104776
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.55116731
32* BRD4_25478319_ChIP-Seq_HGPS_Human1.54880823
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53088559
34SMC1_22415368_ChIP-Seq_MEFs_Mouse1.52664741
35* UBF1/2_26484160_Chip-Seq_HMECs_Human1.48596928
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46557544
37* KDM2B_26808549_Chip-Seq_K562_Human1.46017890
38NFIB_24661679_ChIP-Seq_LUNG_Mouse1.43188113
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42255534
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.39791036
41* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39677179
42GATA1_22025678_ChIP-Seq_K562_Human1.37495041
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35427279
44* KDM2B_26808549_Chip-Seq_DND41_Human1.34482061
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34410480
46JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32384745
47VDR_21846776_ChIP-Seq_THP-1_Human1.32334210
48SMC3_22415368_ChIP-Seq_MEFs_Mouse1.30663477
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30124546
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29770606
51* GATA4_25053715_ChIP-Seq_YYC3_Human1.26914098
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.22537156
53HNF4A_19822575_ChIP-Seq_HepG2_Human1.22183783
54* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21284684
55* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19878384
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18454297
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18423538
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17356927
59TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17349316
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16872663
61TCF7_22412390_ChIP-Seq_EML_Mouse1.15005862
62TP53_23651856_ChIP-Seq_MEFs_Mouse1.13706867
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12684299
64* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12671850
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12097335
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09712277
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09149076
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08730493
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08540743
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08082306
71VDR_24763502_ChIP-Seq_THP-1_Human1.08066141
72TET1_21490601_ChIP-Seq_MESCs_Mouse1.07748619
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06974362
74ZNF263_19887448_ChIP-Seq_K562_Human1.06384198
75SOX2_20726797_ChIP-Seq_SW620_Human1.05239223
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04040306
77SA1_22415368_ChIP-Seq_MEFs_Mouse1.03628193
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03349482
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03306434
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03210548
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.01986391
82* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00421693
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.00075963
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99599915
85* SA1_27219007_Chip-Seq_ERYTHROID_Human0.99249080
86NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94020346
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94020346
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93545701
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93153503
90HTT_18923047_ChIP-ChIP_STHdh_Human0.92244213
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92171560
92* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92032946
93SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91233496
94RACK7_27058665_Chip-Seq_MCF-7_Human0.90621502
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.90302027
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.88474154
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88053252
98SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88002149
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87282199
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86819556
101P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86057713
102* LXR_22292898_ChIP-Seq_THP-1_Human0.85943422
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81853440
104* GATA6_25053715_ChIP-Seq_YYC3_Human0.81218144
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.79161489
106* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78472638
107CDX2_20551321_ChIP-Seq_CACO-2_Human0.76488999
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76036677
109ATF3_27146783_Chip-Seq_COLON_Human0.75839680
110* GATA3_24758297_ChIP-Seq_MCF-7_Human0.75373261
111NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75006928
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.74927697
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74615887
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.74337954
115GATA2_21666600_ChIP-Seq_HMVEC_Human0.73611651
116* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72995851
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72039373
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71357246
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69574656
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69150748
121CJUN_26792858_Chip-Seq_BT549_Human0.68194225
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.67123122
123TBX20_22080862_ChIP-Seq_HEART_Mouse0.67123122
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66821090
125RARA_24833708_ChIP-Seq_LIVER_Mouse0.65946721
126IRF8_22096565_ChIP-ChIP_GC-B_Human0.65021759
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.64446462
128* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64356782
129PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63719429
130HIF1A_21447827_ChIP-Seq_MCF-7_Human0.63194932
131* FOXA1_25552417_ChIP-Seq_VCAP_Human0.63081216
132AUTS2_25519132_ChIP-Seq_293T-REX_Human0.62112649
133* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.61762718
134* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.61762718
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.61655957
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60544314
137ELK3_25401928_ChIP-Seq_HUVEC_Human0.59094263
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.58883537
139* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.58800366
140CEBPB_22108803_ChIP-Seq_LS180_Human0.58303015
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57817571
142TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.56977396
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.56897317
144GATA2_19941826_ChIP-Seq_K562_Human0.56063840
145RARB_24833708_ChIP-Seq_LIVER_Mouse0.55884893
146* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.54677728
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54401222
148CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.53632237
149ERG_21242973_ChIP-ChIP_JURKAT_Human0.52671700
150P53_21459846_ChIP-Seq_SAOS-2_Human0.51922936
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51867877
152FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.51807678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.13532427
2MP0005360_urolithiasis6.29064570
3MP0005085_abnormal_gallbladder_physiolo5.58377436
4MP0005365_abnormal_bile_salt5.49577900
5MP0008875_abnormal_xenobiotic_pharmacok4.12643499
6MP0003806_abnormal_nucleotide_metabolis3.51165551
7MP0003252_abnormal_bile_duct3.42690243
8MP0005083_abnormal_biliary_tract3.36830567
9MP0005257_abnormal_intraocular_pressure3.29098072
10MP0010329_abnormal_lipoprotein_level3.23302053
11MP0001666_abnormal_nutrient_absorption2.95651223
12MP0009840_abnormal_foam_cell2.81617726
13MP0003705_abnormal_hypodermis_morpholog2.43123541
14MP0003191_abnormal_cellular_cholesterol2.38796183
15MP0003195_calcinosis2.36950396
16MP0005332_abnormal_amino_acid2.35664466
17MP0008438_abnormal_cutaneous_collagen2.26621812
18MP0004019_abnormal_vitamin_homeostasis2.04801136
19MP0003091_abnormal_cell_migration2.00620068
20MP0000609_abnormal_liver_physiology1.97073157
21MP0002118_abnormal_lipid_homeostasis1.96828849
22MP0002877_abnormal_melanocyte_morpholog1.96024211
23MP0005623_abnormal_meninges_morphology1.93252378
24MP0003868_abnormal_feces_composition1.82645811
25MP0005508_abnormal_skeleton_morphology1.81852466
26MP0002138_abnormal_hepatobiliary_system1.80795770
27MP0001849_ear_inflammation1.75550887
28MP0005319_abnormal_enzyme/_coenzyme1.66377126
29MP0000767_abnormal_smooth_muscle1.65827336
30MP0005275_abnormal_skin_tensile1.59333687
31MP0004858_abnormal_nervous_system1.57820093
32MP0000751_myopathy1.46944680
33MP0010352_gastrointestinal_tract_polyps1.42597585
34MP0003011_delayed_dark_adaptation1.42149778
35MP0005220_abnormal_exocrine_pancreas1.34909372
36MP0005390_skeleton_phenotype1.34462642
37MP0002254_reproductive_system_inflammat1.32589902
38MP0001881_abnormal_mammary_gland1.32588294
39MP0003941_abnormal_skin_development1.30487704
40MP0001764_abnormal_homeostasis1.27381428
41MP0005584_abnormal_enzyme/coenzyme_acti1.26695506
42MP0009643_abnormal_urine_homeostasis1.24201202
43MP0002998_abnormal_bone_remodeling1.23806652
44MP0009384_cardiac_valve_regurgitation1.22572043
45MP0002060_abnormal_skin_morphology1.21681699
46MP0003950_abnormal_plasma_membrane1.20661772
47MP0010030_abnormal_orbit_morphology1.19349346
48MP0005451_abnormal_body_composition1.18861769
49MP0010368_abnormal_lymphatic_system1.17600781
50MP0000858_altered_metastatic_potential1.17506410
51MP0003186_abnormal_redox_activity1.17081502
52MP0001533_abnormal_skeleton_physiology1.15486247
53MP0005076_abnormal_cell_differentiation1.14063699
54MP0003448_altered_tumor_morphology1.12300268
55MP0000598_abnormal_liver_morphology1.09313072
56MP0005670_abnormal_white_adipose1.08899353
57MP0003172_abnormal_lysosome_physiology1.08718843
58MP0002796_impaired_skin_barrier1.08637690
59MP0005595_abnormal_vascular_smooth1.07060260
60MP0000013_abnormal_adipose_tissue1.06588712
61MP0009764_decreased_sensitivity_to1.05911507
62MP0000534_abnormal_ureter_morphology1.05128425
63MP0002108_abnormal_muscle_morphology1.03067571
64MP0003656_abnormal_erythrocyte_physiolo1.02196928
65MP0000428_abnormal_craniofacial_morphol1.01902871
66MP0001299_abnormal_eye_distance/1.01071304
67MP0000343_altered_response_to1.00890150
68MP0002933_joint_inflammation0.99934193
69MP0000733_abnormal_muscle_development0.98672513
70MP0005647_abnormal_sex_gland0.96510735
71MP0003942_abnormal_urinary_system0.94528868
72MP0010234_abnormal_vibrissa_follicle0.94130859
73MP0001348_abnormal_lacrimal_gland0.92903957
74MP0003115_abnormal_respiratory_system0.92497578
75MP0009763_increased_sensitivity_to0.91322582
76MP0005023_abnormal_wound_healing0.90623208
77MP0008260_abnormal_autophagy0.90414968
78MP0005084_abnormal_gallbladder_morpholo0.89094950
79MP0005636_abnormal_mineral_homeostasis0.87243298
80MP0003795_abnormal_bone_structure0.86175354
81MP0003329_amyloid_beta_deposits0.85609120
82MP0004510_myositis0.84729759
83MP0005165_increased_susceptibility_to0.84708208
84MP0005408_hypopigmentation0.84297842
85MP0009053_abnormal_anal_canal0.83865652
86MP0005197_abnormal_uvea_morphology0.83781710
87MP0005409_darkened_coat_color0.82166747
88MP0004130_abnormal_muscle_cell0.81669019
89MP0000681_abnormal_thyroid_gland0.81527104
90MP0009780_abnormal_chondrocyte_physiolo0.81483472
91MP0009697_abnormal_copulation0.81025434
92MP0003300_gastrointestinal_ulcer0.80809469
93MP0003566_abnormal_cell_adhesion0.80170199
94MP0008469_abnormal_protein_level0.79513608
95MP0000163_abnormal_cartilage_morphology0.79337052
96MP0000762_abnormal_tongue_morphology0.78754262
97MP0001243_abnormal_dermal_layer0.78475496
98MP0001614_abnormal_blood_vessel0.77942781
99MP0009642_abnormal_blood_homeostasis0.76817316
100MP0002113_abnormal_skeleton_development0.76352788
101MP0005388_respiratory_system_phenotype0.75599355
102MP0002133_abnormal_respiratory_system0.75599355
103MP0001915_intracranial_hemorrhage0.75005567
104MP0006082_CNS_inflammation0.75005418
105MP0000003_abnormal_adipose_tissue0.74970010
106MP0001175_abnormal_lung_morphology0.74536157
107MP0000604_amyloidosis0.74285123
108MP0000613_abnormal_salivary_gland0.71795250
109MP0002089_abnormal_postnatal_growth/wei0.71523132
110MP0005334_abnormal_fat_pad0.71356347
111MP0002128_abnormal_blood_circulation0.71342613
112MP0002295_abnormal_pulmonary_circulatio0.70784722
113MP0005666_abnormal_adipose_tissue0.70488782
114MP0005503_abnormal_tendon_morphology0.70226010
115MP0002168_other_aberrant_phenotype0.69647070
116MP0003453_abnormal_keratinocyte_physiol0.69592728
117MP0001756_abnormal_urination0.69183884
118MP0005395_other_phenotype0.68882279
119MP0002078_abnormal_glucose_homeostasis0.68858350
120MP0004272_abnormal_basement_membrane0.68417303
121MP0005376_homeostasis/metabolism_phenot0.68213976
122MP0000467_abnormal_esophagus_morphology0.68157044
123MP0002971_abnormal_brown_adipose0.68152051
124MP0001542_abnormal_bone_strength0.67153836
125MP0000579_abnormal_nail_morphology0.65572288
126MP0000462_abnormal_digestive_system0.65565618
127MP0003279_aneurysm0.65279951
128MP0003828_pulmonary_edema0.64857006
129MP0000750_abnormal_muscle_regeneration0.64249692
130MP0000759_abnormal_skeletal_muscle0.63359704
131MP0010386_abnormal_urinary_bladder0.62119112
132MP0000432_abnormal_head_morphology0.62063472
133MP0003385_abnormal_body_wall0.61622678
134MP0009765_abnormal_xenobiotic_induced0.61611019
135MP0002115_abnormal_skeleton_extremities0.61550860
136MP0010771_integument_phenotype0.60840786
137MP0005164_abnormal_response_to0.60727676
138MP0002249_abnormal_larynx_morphology0.59879468
139MP0001661_extended_life_span0.58956045
140MP0004264_abnormal_extraembryonic_tissu0.58908524
141MP0002876_abnormal_thyroid_physiology0.58159806
142MP0006054_spinal_hemorrhage0.57154861
143MP0005464_abnormal_platelet_physiology0.54869703
144MP0005501_abnormal_skin_physiology0.54775002
145MP0005448_abnormal_energy_balance0.54520955
146MP0005248_abnormal_Harderian_gland0.54013771
147MP0005058_abnormal_lysosome_morphology0.51513726
148MP0004782_abnormal_surfactant_physiolog0.51256172
149MP0004185_abnormal_adipocyte_glucose0.50425733
150MP0004947_skin_inflammation0.49171122
151MP0002896_abnormal_bone_mineralization0.48955295
152MP0002136_abnormal_kidney_physiology0.48132789
153MP0002928_abnormal_bile_duct0.48116749
154MP0000639_abnormal_adrenal_gland0.47956863
155MP0000249_abnormal_blood_vessel0.47376724
156MP0001958_emphysema0.47082849
157MP0003436_decreased_susceptibility_to0.46184814
158MP0001216_abnormal_epidermal_layer0.45938898
159MP0004883_abnormal_blood_vessel0.45356349
160MP0003724_increased_susceptibility_to0.45183637
161MP0000627_abnormal_mammary_gland0.44855628
162MP0008004_abnormal_stomach_pH0.44174900
163MP0009115_abnormal_fat_cell0.43766082
164MP0003638_abnormal_response/metabolism_0.43162266
165MP0002098_abnormal_vibrissa_morphology0.42282915

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.05034506
2Intrahepatic cholestasis (HP:0001406)6.47458118
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.30760514
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.03406316
5Xanthomatosis (HP:0000991)5.72100409
6Prolonged partial thromboplastin time (HP:0003645)5.70967495
7Complement deficiency (HP:0004431)5.29497027
8Hypobetalipoproteinemia (HP:0003563)5.28427031
9Hyperlipoproteinemia (HP:0010980)4.90373098
10Vascular tortuosity (HP:0004948)4.83954580
11Aortic aneurysm (HP:0004942)4.59980492
12Ankle contracture (HP:0006466)4.59653799
13Abnormality of the common coagulation pathway (HP:0010990)4.54121468
14Cervical subluxation (HP:0003308)4.39553213
15Arterial tortuosity (HP:0005116)4.35052231
16Joint hemorrhage (HP:0005261)4.25626845
17Hypolipoproteinemia (HP:0010981)4.24492391
18Vertebral compression fractures (HP:0002953)4.19058109
19Abnormality of the intrinsic pathway (HP:0010989)4.08017109
20Hypoalphalipoproteinemia (HP:0003233)4.00307081
21Epidermoid cyst (HP:0200040)3.97124478
22Bladder diverticulum (HP:0000015)3.95418992
23Fat malabsorption (HP:0002630)3.94600034
24Abnormality of complement system (HP:0005339)3.93633888
25Hyperammonemia (HP:0001987)3.91502577
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.88546656
27Hyperglycinemia (HP:0002154)3.87665751
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.85906077
29Broad metatarsal (HP:0001783)3.81434604
30Ketosis (HP:0001946)3.71858726
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.70933498
32Follicular hyperkeratosis (HP:0007502)3.64488208
33Atrophic scars (HP:0001075)3.64369241
34Wormian bones (HP:0002645)3.49781660
35Abnormality of methionine metabolism (HP:0010901)3.47612842
36Spondylolisthesis (HP:0003302)3.46083171
37Hyperglycinuria (HP:0003108)3.43254358
38Hypoglycemic coma (HP:0001325)3.42639230
39Soft skin (HP:0000977)3.42127559
40Spinal rigidity (HP:0003306)3.41373793
41Abnormality of aspartate family amino acid metabolism (HP:0010899)3.35732020
42Abnormality of glycine metabolism (HP:0010895)3.33673843
43Abnormality of serine family amino acid metabolism (HP:0010894)3.33673843
44Myocardial infarction (HP:0001658)3.24796880
45Type 1 muscle fiber predominance (HP:0003803)3.24259696
46Fragile skin (HP:0001030)3.19210027
47Abnormality of dentin (HP:0010299)3.15550436
48Shallow orbits (HP:0000586)3.14621938
49Steatorrhea (HP:0002570)3.11740187
50Dilatation of the ascending aorta (HP:0005111)3.11071443
51Abnormality of pyrimidine metabolism (HP:0004353)3.10294499
52Conjugated hyperbilirubinemia (HP:0002908)3.09427958
53Hypercholesterolemia (HP:0003124)3.09298691
54Blue sclerae (HP:0000592)3.03985624
55Spontaneous abortion (HP:0005268)3.02155830
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.98822629
57Slender build (HP:0001533)2.96810796
58Abnormality of nucleobase metabolism (HP:0010932)2.95907422
59Abnormality of fatty-acid metabolism (HP:0004359)2.93214444
60Cerebral aneurysm (HP:0004944)2.91265656
61Vascular calcification (HP:0004934)2.89261545
62Abnormality of purine metabolism (HP:0004352)2.88713884
63Cardiovascular calcification (HP:0011915)2.86921802
64Neonatal short-limb short stature (HP:0008921)2.85583135
65Osteolytic defects of the hand bones (HP:0009699)2.83963294
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.83963294
67Skin nodule (HP:0200036)2.73744621
68Genu recurvatum (HP:0002816)2.73038832
69Hyperbilirubinemia (HP:0002904)2.72199017
70Protrusio acetabuli (HP:0003179)2.70859429
71Hepatocellular carcinoma (HP:0001402)2.69024998
72Mildly elevated creatine phosphokinase (HP:0008180)2.68834722
73Increased variability in muscle fiber diameter (HP:0003557)2.68570785
74Aneurysm (HP:0002617)2.64476886
75Ketoacidosis (HP:0001993)2.62048752
76Joint laxity (HP:0001388)2.61774693
77Peritonitis (HP:0002586)2.61574072
78Dysostosis multiplex (HP:0000943)2.60252524
79Increased connective tissue (HP:0009025)2.58075602
80Gout (HP:0001997)2.56445760
81Malnutrition (HP:0004395)2.56033591
82Short nail (HP:0001799)2.54658734
83Systemic lupus erythematosus (HP:0002725)2.53893340
84Long toe (HP:0010511)2.51404654
85Mitral regurgitation (HP:0001653)2.49501698
86Aortic regurgitation (HP:0001659)2.49414828
87Distal upper limb amyotrophy (HP:0007149)2.48657368
88Upper limb amyotrophy (HP:0009129)2.48657368
89Biconcave vertebral bodies (HP:0004586)2.48581246
90Elbow flexion contracture (HP:0002987)2.48256029
91Abnormality of serum amino acid levels (HP:0003112)2.48135914
92Joint stiffness (HP:0001387)2.46979879
93Menorrhagia (HP:0000132)2.46887542
94Urinary glycosaminoglycan excretion (HP:0003541)2.46365281
95Mucopolysacchariduria (HP:0008155)2.46365281
96Premature rupture of membranes (HP:0001788)2.46237743
97Mitral stenosis (HP:0001718)2.46201182
98Mitral valve prolapse (HP:0001634)2.44160706
99Spastic diplegia (HP:0001264)2.41697418
100Abnormality of polysaccharide metabolism (HP:0011012)2.37841523
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.37841523
102Abnormality of mucopolysaccharide metabolism (HP:0011020)2.37841523
103Disproportionate tall stature (HP:0001519)2.37703626
104Hyperextensible skin (HP:0000974)2.36396659
105Amyloidosis (HP:0011034)2.35060956
106Esophageal varix (HP:0002040)2.34960886
107Abnormality of the acetabulum (HP:0003170)2.34559086
108Bowel diverticulosis (HP:0005222)2.33243397
109Abnormality of skeletal muscle fiber size (HP:0012084)2.31026577
110Glomerulonephritis (HP:0000099)2.30540351
111Hemorrhage of the eye (HP:0011885)2.27836082
112Achilles tendon contracture (HP:0001771)2.27471158
113Right ventricular cardiomyopathy (HP:0011663)2.27290799
114Delayed CNS myelination (HP:0002188)2.25031399
115Pancreatitis (HP:0001733)2.22794473
116Abnormal gallbladder morphology (HP:0012437)2.21418755
117Abnormality of liposaccharide metabolism (HP:0010968)2.20499740
118Abnormality of glycosphingolipid metabolism (HP:0004343)2.20499740
119Abnormality of glycolipid metabolism (HP:0010969)2.20499740
120Nephritis (HP:0000123)2.19336191
121Overgrowth (HP:0001548)2.19093289
122Hypoventilation (HP:0002791)2.18518652
123Metabolic acidosis (HP:0001942)2.18417909
124Cholelithiasis (HP:0001081)2.18205064
125Gingival bleeding (HP:0000225)2.16448253
126Distal lower limb amyotrophy (HP:0008944)2.15973734
127Natal tooth (HP:0000695)2.14086359
128Aortic valve stenosis (HP:0001650)2.13261916
129Abnormal cartilage morphology (HP:0002763)2.10635139
130Generalized amyotrophy (HP:0003700)2.10466442
131Opisthotonus (HP:0002179)2.10009211
132Thin bony cortex (HP:0002753)2.07973811
133Cholecystitis (HP:0001082)2.06676079
134Abnormal gallbladder physiology (HP:0012438)2.06676079
135Lethargy (HP:0001254)2.05831098
136Dicarboxylic aciduria (HP:0003215)2.05058063
137Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05058063
138Ectopia lentis (HP:0001083)2.05040823
139Distal lower limb muscle weakness (HP:0009053)2.05013337
140Hypoglycemic seizures (HP:0002173)2.03481683
141Ulnar bowing (HP:0003031)2.02899093
142Wrist flexion contracture (HP:0001239)2.01974992
143Broad face (HP:0000283)2.00450993
144Coronal craniosynostosis (HP:0004440)2.00371645
145Hypochromic microcytic anemia (HP:0004840)2.00006961
146Hyperacusis (HP:0010780)1.99360972
147Rectal prolapse (HP:0002035)1.99270123
148Recurrent gram-negative bacterial infections (HP:0005420)1.97691104
149Camptodactyly of toe (HP:0001836)1.97587154
150Hydroxyprolinuria (HP:0003080)1.97197117
151Abnormality of proline metabolism (HP:0010907)1.97197117
152Emphysema (HP:0002097)1.96565881
153Acanthocytosis (HP:0001927)1.96205559
154Back pain (HP:0003418)1.95069891
155Aortic dissection (HP:0002647)1.94981902
156Hand muscle atrophy (HP:0009130)1.94949954
157Abnormality of transition element cation homeostasis (HP:0011030)1.94747383
158Ovoid vertebral bodies (HP:0003300)1.94368171
159Absent frontal sinuses (HP:0002688)1.93874777
160Thrombophlebitis (HP:0004418)1.92659751
161Abnormality of the distal phalanges of the toes (HP:0010182)1.91775950
162Irritability (HP:0000737)1.91250178
163Abnormality of iron homeostasis (HP:0011031)1.90571059
164Increased mean platelet volume (HP:0011877)1.90285498
165Delayed cranial suture closure (HP:0000270)1.88441074
166Asymmetric septal hypertrophy (HP:0001670)1.88406501
167Rickets (HP:0002748)1.88344960
168Abnormality of the Achilles tendon (HP:0005109)1.88119926
169Late onset (HP:0003584)1.87354042
170Neonatal onset (HP:0003623)1.87331135
171Abnormal enzyme/coenzyme activity (HP:0012379)1.86368667
172Abnormal delivery (HP:0001787)1.86247198
173Hypophosphatemic rickets (HP:0004912)1.83085699
174Nonimmune hydrops fetalis (HP:0001790)1.82773251
175Coxa vara (HP:0002812)1.82126610
176Sensorimotor neuropathy (HP:0007141)1.81562548
177Protruding ear (HP:0000411)1.81224739
178Brushfield spots (HP:0001088)1.80628187
179Stroke (HP:0001297)1.80566936
180Abnormality of the gallbladder (HP:0005264)1.80490684
181Pulmonary artery stenosis (HP:0004415)1.79517316
182Delayed closure of the anterior fontanelle (HP:0001476)1.79419198
183Inguinal hernia (HP:0000023)1.77625405
184Femoral bowing (HP:0002980)1.76091630
185Obstructive sleep apnea (HP:0002870)1.74494107
186Wide anterior fontanel (HP:0000260)1.73486962
187Abnormality of skull ossification (HP:0002703)1.72143192
188Nuclear cataract (HP:0100018)1.69796220
189Premature skin wrinkling (HP:0100678)1.69536416
190Arachnodactyly (HP:0001166)1.68205803
191Thoracolumbar scoliosis (HP:0002944)1.67162194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.25429822
2ERN14.68864793
3SIK14.11044690
4TRIB33.48048397
5FGFR43.21778036
6PKN23.01789211
7LATS12.86868681
8TAOK32.54799913
9NTRK12.12746160
10PTK62.12185595
11PIK3CG2.11345607
12PAK41.96099530
13EPHA21.92999769
14ERBB41.92062646
15INSRR1.87208887
16SMG11.78051346
17FRK1.75549703
18MYLK1.67015595
19MST1R1.66200017
20GRK51.65680016
21RIPK11.61956640
22ICK1.58622418
23CDC42BPA1.58128886
24TTN1.51255970
25PRKD21.51042586
26IRAK31.50892306
27LIMK11.49599849
28NEK91.49328368
29MAP3K31.46255093
30FLT31.45569547
31PRPF4B1.43811598
32EPHA31.39557180
33GRK61.38043755
34GRK71.33897192
35EPHB11.30369674
36TGFBR21.29822199
37TYK21.29637239
38MAPKAPK31.28784454
39STK381.26821984
40FER1.25933754
41RPS6KA21.22180148
42PTK21.21976997
43PDGFRA1.21857615
44PIM21.18696892
45MAPK111.18271956
46AKT31.16068011
47TAOK21.15741294
48ARAF1.12822624
49CAMK1D1.12618192
50DDR21.12416117
51STK38L1.11866208
52EEF2K1.09034911
53MOS1.05084186
54MAP3K61.04603687
55TBK11.04425490
56MAP2K30.99102605
57EPHB20.97620676
58PAK20.94674768
59KDR0.93522520
60ABL20.93221877
61MET0.92073878
62JAK10.91949522
63PRKG20.90716182
64PDK20.88327519
65PRKAA20.87615307
66MAP3K130.86156065
67ADRBK10.85960947
68KIT0.85739007
69JAK20.84624811
70PIK3CA0.84554117
71TIE10.83069102
72BMX0.82209624
73LATS20.81529798
74DYRK1B0.81522730
75GRK10.81401828
76MAP3K70.80557937
77LRRK20.80486901
78TRPM70.79210659
79ADRBK20.77187466
80ERBB20.77090393
81MAP2K20.74981939
82KSR20.72729856
83MAP2K40.72671962
84CDK120.69770228
85MAPK70.67583947
86STK30.67497838
87MAP2K10.66623154
88RPS6KC10.66347117
89RPS6KL10.66347117
90MTOR0.65833852
91GSK3A0.65537560
92PRKD30.65443057
93ROCK20.65161348
94TESK20.64389831
95CDK60.62164424
96DAPK20.61623726
97FGFR20.60307634
98PAK30.56125889
99MAP3K20.56101101
100PDK30.55953727
101PDK40.55953727
102CAMK1G0.55708889
103CDK80.55577083
104MAP3K10.54910055
105ILK0.54428940
106NUAK10.53304089
107RET0.52905751
108ROCK10.52557131
109ZAP700.51081895
110MAPK40.50829626
111MELK0.50441447
112MAP3K100.50298811
113MARK20.50004565
114MAPK120.49927169
115JAK30.49886089
116MAP3K80.49852682
117PDGFRB0.49493098
118PTK2B0.49184035
119SCYL20.48472925
120CAMK2G0.48188607
121FGFR30.47707455
122IRAK10.47584753
123CSK0.46791543
124MAP3K140.44678061
125RPS6KA60.44624310
126HIPK20.44281422
127MAP3K110.44074446
128IGF1R0.43996784
129PRKCZ0.42294535
130DMPK0.42065364
131MAPKAPK20.41063077
132BRAF0.40369530
133MAPK150.38156982
134CLK10.38130955
135PRKAA10.38007063
136PDPK10.37894700
137FGFR10.35554925
138WNK10.35512929
139MAP2K60.34745801
140EGFR0.33758463
141IKBKE0.33273678
142PAK10.32914441
143PRKACG0.31464307
144NME20.29289455
145PRKD10.29183434
146TESK10.29165527
147LMTK20.28963723
148DAPK30.28342417
149CSF1R0.27584515
150RPS6KB20.27327806

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.22228694
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.27503214
3Nitrogen metabolism_Homo sapiens_hsa009103.26953382
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.11482670
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93912594
6Complement and coagulation cascades_Homo sapiens_hsa046102.86799814
7Arginine biosynthesis_Homo sapiens_hsa002202.84035635
8Tryptophan metabolism_Homo sapiens_hsa003802.56827777
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56683966
10Fatty acid degradation_Homo sapiens_hsa000712.49359890
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44471667
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38510509
13Caffeine metabolism_Homo sapiens_hsa002322.34771713
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33044554
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11418391
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06263553
17Chemical carcinogenesis_Homo sapiens_hsa052042.01187987
18PPAR signaling pathway_Homo sapiens_hsa033201.99374842
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98979230
20Peroxisome_Homo sapiens_hsa041461.96105597
21Propanoate metabolism_Homo sapiens_hsa006401.93666415
22Histidine metabolism_Homo sapiens_hsa003401.88690490
23Fatty acid metabolism_Homo sapiens_hsa012121.87731341
24Proteoglycans in cancer_Homo sapiens_hsa052051.83445162
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.82783958
26Butanoate metabolism_Homo sapiens_hsa006501.76926539
27Staphylococcus aureus infection_Homo sapiens_hsa051501.74235793
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.73153972
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70548831
30beta-Alanine metabolism_Homo sapiens_hsa004101.66676541
31Sulfur metabolism_Homo sapiens_hsa009201.66636512
32Selenocompound metabolism_Homo sapiens_hsa004501.64069477
33Retinol metabolism_Homo sapiens_hsa008301.64001552
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.59843578
35Fat digestion and absorption_Homo sapiens_hsa049751.54855176
36Phenylalanine metabolism_Homo sapiens_hsa003601.54665464
37Chronic myeloid leukemia_Homo sapiens_hsa052201.52864233
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51832919
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.45540646
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42026483
41Bile secretion_Homo sapiens_hsa049761.41025997
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40955818
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40413080
44Small cell lung cancer_Homo sapiens_hsa052221.40280731
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36979229
46Tyrosine metabolism_Homo sapiens_hsa003501.36966017
47Pyruvate metabolism_Homo sapiens_hsa006201.36788269
48Folate biosynthesis_Homo sapiens_hsa007901.34883845
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.27627522
50ABC transporters_Homo sapiens_hsa020101.22338486
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.22111732
52Starch and sucrose metabolism_Homo sapiens_hsa005001.21703205
53Fatty acid elongation_Homo sapiens_hsa000621.20520544
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18122320
55Steroid biosynthesis_Homo sapiens_hsa001001.17851422
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15670011
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.15447014
58Pertussis_Homo sapiens_hsa051331.14856114
59Fatty acid biosynthesis_Homo sapiens_hsa000611.13844221
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13123064
61Vibrio cholerae infection_Homo sapiens_hsa051101.12871793
62Adherens junction_Homo sapiens_hsa045201.12794339
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.12763338
64TNF signaling pathway_Homo sapiens_hsa046681.12591242
65Shigellosis_Homo sapiens_hsa051311.10847260
66Dilated cardiomyopathy_Homo sapiens_hsa054141.09459880
67Pancreatic cancer_Homo sapiens_hsa052121.08765223
68Biosynthesis of amino acids_Homo sapiens_hsa012301.08749958
69PI3K-Akt signaling pathway_Homo sapiens_hsa041511.06210109
70Vitamin digestion and absorption_Homo sapiens_hsa049771.05933535
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05922522
72Melanoma_Homo sapiens_hsa052181.04346029
73Sulfur relay system_Homo sapiens_hsa041221.03143919
74Carbon metabolism_Homo sapiens_hsa012001.03037519
75Acute myeloid leukemia_Homo sapiens_hsa052211.02264832
76Renal cell carcinoma_Homo sapiens_hsa052111.00847447
77Notch signaling pathway_Homo sapiens_hsa043301.00318187
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00250173
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99190201
80MicroRNAs in cancer_Homo sapiens_hsa052060.98732540
81Salmonella infection_Homo sapiens_hsa051320.97179727
82Osteoclast differentiation_Homo sapiens_hsa043800.96468707
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.95274510
84Endocytosis_Homo sapiens_hsa041440.94802693
85Pathways in cancer_Homo sapiens_hsa052000.94575586
86Arginine and proline metabolism_Homo sapiens_hsa003300.93927009
87Toxoplasmosis_Homo sapiens_hsa051450.93465593
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.92055617
89Glioma_Homo sapiens_hsa052140.88605585
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87948771
91TGF-beta signaling pathway_Homo sapiens_hsa043500.87447752
92Vitamin B6 metabolism_Homo sapiens_hsa007500.86924363
93VEGF signaling pathway_Homo sapiens_hsa043700.85872377
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.85806051
95Phagosome_Homo sapiens_hsa041450.85790643
96Prostate cancer_Homo sapiens_hsa052150.85682216
97Glycerolipid metabolism_Homo sapiens_hsa005610.84409065
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83692192
99GnRH signaling pathway_Homo sapiens_hsa049120.82480655
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81951159
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81524369
102Glutathione metabolism_Homo sapiens_hsa004800.80414123
103Thyroid cancer_Homo sapiens_hsa052160.80393357
104Sphingolipid metabolism_Homo sapiens_hsa006000.79252014
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75761355
106Endometrial cancer_Homo sapiens_hsa052130.75376039
107Lysine degradation_Homo sapiens_hsa003100.74508130
108Apoptosis_Homo sapiens_hsa042100.74069228
109mTOR signaling pathway_Homo sapiens_hsa041500.73446342
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73233399
111Estrogen signaling pathway_Homo sapiens_hsa049150.72038420
112Rap1 signaling pathway_Homo sapiens_hsa040150.71116313
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70728243
114Non-small cell lung cancer_Homo sapiens_hsa052230.70371164
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69888474
116Hepatitis B_Homo sapiens_hsa051610.69245253
117Gap junction_Homo sapiens_hsa045400.67832322
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67533695
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67257137
120Hippo signaling pathway_Homo sapiens_hsa043900.66462265
121Platelet activation_Homo sapiens_hsa046110.63384063
122One carbon pool by folate_Homo sapiens_hsa006700.63219615
123Prolactin signaling pathway_Homo sapiens_hsa049170.62977342
124Tight junction_Homo sapiens_hsa045300.60861249
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60824168
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60796976
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59683605
128Axon guidance_Homo sapiens_hsa043600.59543704
129Pentose phosphate pathway_Homo sapiens_hsa000300.57558277
130Melanogenesis_Homo sapiens_hsa049160.53654393
131ErbB signaling pathway_Homo sapiens_hsa040120.52445614
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52389263
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51258868
134Basal cell carcinoma_Homo sapiens_hsa052170.50360842
135HTLV-I infection_Homo sapiens_hsa051660.50225657
136Galactose metabolism_Homo sapiens_hsa000520.46224937
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45004962
138Choline metabolism in cancer_Homo sapiens_hsa052310.44879240
139Tuberculosis_Homo sapiens_hsa051520.43718024
140Mineral absorption_Homo sapiens_hsa049780.43630163
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42882734
142Metabolic pathways_Homo sapiens_hsa011000.41837511
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38983290
144Insulin resistance_Homo sapiens_hsa049310.38252484
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.37497923
146Prion diseases_Homo sapiens_hsa050200.33321162
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32780266
148Protein digestion and absorption_Homo sapiens_hsa049740.29708333
149Linoleic acid metabolism_Homo sapiens_hsa005910.27096681
150Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26023884
151Bladder cancer_Homo sapiens_hsa052190.24979866
152ECM-receptor interaction_Homo sapiens_hsa045120.24440268
153Fructose and mannose metabolism_Homo sapiens_hsa000510.23026855
154AMPK signaling pathway_Homo sapiens_hsa041520.13577040
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.13132883
156Amoebiasis_Homo sapiens_hsa051460.12842900
157Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11982041
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09828632
159Glucagon signaling pathway_Homo sapiens_hsa049220.09808379
160Arachidonic acid metabolism_Homo sapiens_hsa005900.07283878
161Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04376481
162Glycosaminoglycan degradation_Homo sapiens_hsa005310.02998977
163N-Glycan biosynthesis_Homo sapiens_hsa005100.01798590
164Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1129244
165Protein export_Homo sapiens_hsa03060-0.0906824
166Other glycan degradation_Homo sapiens_hsa00511-0.0801385
167Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0752790
168Malaria_Homo sapiens_hsa05144-0.0724594
169Focal adhesion_Homo sapiens_hsa04510-0.0488373
170Hepatitis C_Homo sapiens_hsa05160-0.0449146
171Insulin signaling pathway_Homo sapiens_hsa04910-0.0311540
172Lysosome_Homo sapiens_hsa04142-0.0289854
173Renin-angiotensin system_Homo sapiens_hsa04614-0.0198911
174Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0079403

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