QSOX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 [PubMed 14633699]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.87976504
2Golgi transport vesicle coating (GO:0048200)7.87976504
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.74146418
4exocrine pancreas development (GO:0031017)6.64566173
5protein retention in ER lumen (GO:0006621)6.21543364
6nuclear pore complex assembly (GO:0051292)6.14074629
7protein maturation by protein folding (GO:0022417)5.30456140
8mitotic chromosome condensation (GO:0007076)5.28892918
9nuclear pore organization (GO:0006999)5.19807861
10activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.12739439
11DNA unwinding involved in DNA replication (GO:0006268)5.11327040
12positive regulation of nuclease activity (GO:0032075)4.95394180
13retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.81527786
14endocrine pancreas development (GO:0031018)4.77936857
15COPII vesicle coating (GO:0048208)4.57876650
16regulation of nuclease activity (GO:0032069)4.51691813
17heterochromatin organization (GO:0070828)4.39683883
18endoplasmic reticulum unfolded protein response (GO:0030968)4.32878500
19ER overload response (GO:0006983)4.32731557
20pore complex assembly (GO:0046931)4.24197392
21regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.22559283
22cellular response to unfolded protein (GO:0034620)4.22525793
23regulation of RNA export from nucleus (GO:0046831)4.05670338
24cellular response to topologically incorrect protein (GO:0035967)4.04845148
25ER-nucleus signaling pathway (GO:0006984)4.04233375
26regulation of histone H3-K27 methylation (GO:0061085)3.98872169
27glandular epithelial cell differentiation (GO:0002067)3.97380267
28spliceosomal tri-snRNP complex assembly (GO:0000244)3.95977772
29intestinal cholesterol absorption (GO:0030299)3.90934518
30activation of Rac GTPase activity (GO:0032863)3.82421317
31negative regulation of histone methylation (GO:0031061)3.74984345
32ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.72385744
33L-alpha-amino acid transmembrane transport (GO:1902475)3.71112347
34response to endoplasmic reticulum stress (GO:0034976)3.70741867
35RNA stabilization (GO:0043489)3.68760145
36mRNA stabilization (GO:0048255)3.68760145
37glandular epithelial cell development (GO:0002068)3.68064034
38vesicle coating (GO:0006901)3.66717470
39peptide hormone processing (GO:0016486)3.66071580
40regulation of nucleobase-containing compound transport (GO:0032239)3.64304053
41intestinal epithelial cell development (GO:0060576)3.62514234
42negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.58683511
43response to unfolded protein (GO:0006986)3.51453784
44mitotic sister chromatid segregation (GO:0000070)3.50592489
45columnar/cuboidal epithelial cell development (GO:0002066)3.48211924
46DNA topological change (GO:0006265)3.47008108
47chromosome condensation (GO:0030261)3.46760188
48sister chromatid segregation (GO:0000819)3.44898300
49mitotic sister chromatid cohesion (GO:0007064)3.43495883
50DNA duplex unwinding (GO:0032508)3.41887472
51type B pancreatic cell development (GO:0003323)3.38487737
52response to topologically incorrect protein (GO:0035966)3.38446749
53protein localization to chromosome, centromeric region (GO:0071459)3.32069020
54regulation of mammary gland epithelial cell proliferation (GO:0033599)3.31639727
55epithelial cell fate commitment (GO:0072148)3.30716720
56DNA replication initiation (GO:0006270)3.30235785
573-UTR-mediated mRNA stabilization (GO:0070935)3.30095521
58polarized epithelial cell differentiation (GO:0030859)3.24230233
59regulation of chromatin binding (GO:0035561)3.22152036
60peptidyl-asparagine modification (GO:0018196)3.21642441
61mitotic nuclear envelope disassembly (GO:0007077)3.19983378
62protein N-linked glycosylation via asparagine (GO:0018279)3.19374432
63protein export from nucleus (GO:0006611)3.19146544
64digestion (GO:0007586)3.18432929
65DNA geometric change (GO:0032392)3.18147351
66ribosomal small subunit biogenesis (GO:0042274)3.17370840
67cellular protein complex localization (GO:0034629)3.15109599
68astrocyte differentiation (GO:0048708)3.13846400
69regulation of translational fidelity (GO:0006450)3.12548440
70sequestering of metal ion (GO:0051238)3.12097242
71focal adhesion assembly (GO:0048041)3.11627359
72cell-substrate adherens junction assembly (GO:0007045)3.11627359
73membrane disassembly (GO:0030397)3.09094553
74nuclear envelope disassembly (GO:0051081)3.09094553
75DNA conformation change (GO:0071103)3.05831914
76glucocorticoid receptor signaling pathway (GO:0042921)3.05030284
77proline biosynthetic process (GO:0006561)3.04393881
78establishment of apical/basal cell polarity (GO:0035089)3.00120215
79DNA strand elongation involved in DNA replication (GO:0006271)2.96592673
80cellular response to vitamin D (GO:0071305)2.96235245
81detection of calcium ion (GO:0005513)2.94333291
82regulation of translational termination (GO:0006449)2.91336770
83DNA packaging (GO:0006323)2.91075974
84insulin secretion (GO:0030073)2.89778443
85planar cell polarity pathway involved in neural tube closure (GO:0090179)2.89390513
86protein N-linked glycosylation (GO:0006487)2.88979397
87DNA strand elongation (GO:0022616)2.88024001
88adherens junction assembly (GO:0034333)2.87853669
89negative regulation of mRNA metabolic process (GO:1903312)2.87276758
90positive regulation of DNA-dependent DNA replication (GO:2000105)2.86746792
91regulation of NFAT protein import into nucleus (GO:0051532)2.86585352
92nucleosome disassembly (GO:0006337)2.86396388
93protein-DNA complex disassembly (GO:0032986)2.86396388
94apical protein localization (GO:0045176)2.86238482
95cellular response to epidermal growth factor stimulus (GO:0071364)2.85418408
96pre-miRNA processing (GO:0031054)2.84469711
97Golgi organization (GO:0007030)2.82556098
98membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.82110159
99histone H3-K36 demethylation (GO:0070544)2.81451502
100protein complex localization (GO:0031503)2.81025936
101negative regulation of mRNA processing (GO:0050686)2.80258015
102peptidyl-proline hydroxylation (GO:0019511)2.79351859
103positive regulation of cell cycle checkpoint (GO:1901978)2.78177758
104protein hydroxylation (GO:0018126)2.77956261
105negative regulation of inclusion body assembly (GO:0090084)2.77167915
106stress granule assembly (GO:0034063)2.77149326
107protein localization to kinetochore (GO:0034501)2.76596191
108chromatin assembly (GO:0031497)2.74730924
109maintenance of protein localization in organelle (GO:0072595)2.74623550
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74249635
111apoptotic process involved in morphogenesis (GO:0060561)2.73978227
112regulation of histone H3-K9 methylation (GO:0051570)2.72336526
113nuclear envelope organization (GO:0006998)2.71808498
114dosage compensation (GO:0007549)2.71135553
115negative regulation of DNA repair (GO:0045738)2.70409727
116zinc ion transport (GO:0006829)2.70237584
117regulation of insulin secretion (GO:0050796)2.70025558
118regulation of mitotic spindle organization (GO:0060236)2.69945122
119regulation of type B pancreatic cell apoptotic process (GO:2000674)2.69756573
120regulation of glucose import in response to insulin stimulus (GO:2001273)2.68581656
121positive regulation of insulin secretion (GO:0032024)2.68096501
122peptidyl-lysine dimethylation (GO:0018027)2.67905252
123negative regulation of insulin secretion (GO:0046676)2.65774511
124cerebellar Purkinje cell layer development (GO:0021680)2.65733360
125regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.65348369
126regulation of histone methylation (GO:0031060)2.64848557
127regulation of sister chromatid cohesion (GO:0007063)2.63882609
128intra-Golgi vesicle-mediated transport (GO:0006891)2.62604161
129growth hormone secretion (GO:0030252)2.62074104
130formation of translation preinitiation complex (GO:0001731)2.61898011
131positive regulation of chromosome segregation (GO:0051984)2.61516627
132establishment or maintenance of monopolar cell polarity (GO:0061339)2.61119552
133establishment of monopolar cell polarity (GO:0061162)2.61119552
134protein localization to microtubule (GO:0035372)2.60773867
135positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.59701312
136cellular zinc ion homeostasis (GO:0006882)2.58593631
137regulation of early endosome to late endosome transport (GO:2000641)2.57667509
138DNA synthesis involved in DNA repair (GO:0000731)2.57288561
139regulation of mRNA stability (GO:0043488)2.57108423
140mitotic metaphase plate congression (GO:0007080)2.55675460
141regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54103129
142mRNA transport (GO:0051028)2.53647987
143response to epidermal growth factor (GO:0070849)2.53287590
144histone H3-K9 demethylation (GO:0033169)2.53127366
145positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.52209412
146cell-substrate junction assembly (GO:0007044)2.52117976
147G1 DNA damage checkpoint (GO:0044783)2.50575800
148negative regulation of glycoprotein biosynthetic process (GO:0010561)2.48969966
149negative regulation of RNA splicing (GO:0033119)2.48877917
1504-hydroxyproline metabolic process (GO:0019471)2.47918654
151mitotic G1 DNA damage checkpoint (GO:0031571)2.46466765
152regulation of histone H3-K4 methylation (GO:0051569)2.45445680
153membrane repolarization during action potential (GO:0086011)2.44921785
154corticosteroid receptor signaling pathway (GO:0031958)2.44908983
155regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.44498769
156magnesium ion transport (GO:0015693)2.44356769
157myelin maintenance (GO:0043217)2.43770958
158erythrocyte maturation (GO:0043249)2.43062280
159regulation of RNA stability (GO:0043487)2.42747438
160signal peptide processing (GO:0006465)2.41860544
161folic acid-containing compound biosynthetic process (GO:0009396)2.41673571
162asymmetric protein localization (GO:0008105)2.40855015
163mesoderm formation (GO:0001707)2.40419425
164ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.39243174
165peptide hormone secretion (GO:0030072)2.36621396
166regulation of peptide hormone secretion (GO:0090276)2.36360740
167regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.34730017
168formation of primary germ layer (GO:0001704)2.34635979
169cellular response to vitamin (GO:0071295)2.33303207
170macroautophagy (GO:0016236)2.32082752
171peptide secretion (GO:0002790)2.31818835
172regulation of peptide secretion (GO:0002791)2.31258789
173ER to Golgi vesicle-mediated transport (GO:0006888)2.30325620
174negative regulation of peptide hormone secretion (GO:0090278)2.27737893
175establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.27560325
176sensory perception of smell (GO:0007608)2.27432861
177negative regulation of glycogen biosynthetic process (GO:0045719)2.26968907
178chemosensory behavior (GO:0007635)2.26828336
179dorsal/ventral axis specification (GO:0009950)2.23755563
180regulation of translational elongation (GO:0006448)2.20518723
181regulation of posttranscriptional gene silencing (GO:0060147)2.19924190
182regulation of gene silencing by miRNA (GO:0060964)2.19924190
183regulation of gene silencing by RNA (GO:0060966)2.19924190
184regulation of growth hormone secretion (GO:0060123)2.18886910
185regulation of calcium ion-dependent exocytosis (GO:0017158)2.18736797
186intestinal absorption (GO:0050892)2.18639912
187regulation of cardioblast proliferation (GO:0003264)2.17708593
188regulation of secondary heart field cardioblast proliferation (GO:0003266)2.17708593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.33192670
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.51084275
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.41715064
4STAT6_21828071_ChIP-Seq_BEAS2B_Human4.32145023
5* MYC_22102868_ChIP-Seq_BL_Human3.76183609
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.14874864
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.03362470
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73144574
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.65150471
10ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.47968777
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44039149
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34979668
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31264228
14VDR_21846776_ChIP-Seq_THP-1_Human2.29621582
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10376531
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06717004
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05462736
18CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.05424885
19GATA1_22025678_ChIP-Seq_K562_Human2.04832350
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.93329073
21TCF7_22412390_ChIP-Seq_EML_Mouse1.91636691
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89634875
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.84266807
24ZNF263_19887448_ChIP-Seq_K562_Human1.83429647
25CLOCK_20551151_ChIP-Seq_293T_Human1.80967156
26AR_21909140_ChIP-Seq_LNCAP_Human1.80924978
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.78525412
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76681565
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72011680
30CHD1_26751641_Chip-Seq_LNCaP_Human1.71993932
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71299045
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.69337013
33XRN2_22483619_ChIP-Seq_HELA_Human1.65080926
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63709986
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62342710
36* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61385097
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59261974
38KDM2B_26808549_Chip-Seq_DND41_Human1.58890333
39* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57196123
40PKCTHETA_26484144_Chip-Seq_BREAST_Human1.57111923
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.54197669
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.52650041
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52570355
44* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52051717
45ZNF274_21170338_ChIP-Seq_K562_Hela1.51380014
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51312017
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.50606637
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47400142
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44187776
50* RUNX1_27514584_Chip-Seq_MCF-7_Human1.43527002
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.40146407
52OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.40022382
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35659644
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35407907
55FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.32924083
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32662606
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.32288158
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32286503
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32052565
60* NCOR1_26117541_ChIP-Seq_K562_Human1.31859386
61FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31840778
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31717318
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31256453
64CREB1_26743006_Chip-Seq_LNCaP_Human1.29644329
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.28688626
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28374070
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.27955464
68GATA6_25053715_ChIP-Seq_YYC3_Human1.27196407
69CIITA_25753668_ChIP-Seq_RAJI_Human1.26932113
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26625197
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25795016
72* KDM2B_26808549_Chip-Seq_K562_Human1.25673056
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25417602
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25048581
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24708341
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24204970
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24051358
78MAF_26560356_Chip-Seq_TH1_Human1.23906389
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23373008
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23030957
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22826695
82ATF3_27146783_Chip-Seq_COLON_Human1.22420593
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.22164385
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21681043
85KDM5A_27292631_Chip-Seq_BREAST_Human1.21591112
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21384264
87FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20529624
88TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.20279409
89* RACK7_27058665_Chip-Seq_MCF-7_Human1.19703036
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19520569
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18956784
92ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18425515
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.15751830
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15651700
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13653427
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12907452
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11989139
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11535816
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10660284
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10184754
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10173116
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09712058
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09091153
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07530455
105TTF2_22483619_ChIP-Seq_HELA_Human1.07471263
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06914782
107DROSHA_22980978_ChIP-Seq_HELA_Human1.06639920
108DCP1A_22483619_ChIP-Seq_HELA_Human1.06112621
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05265636
110KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04936040
111RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04863529
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04755893
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04567187
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04352510
115TP53_22127205_ChIP-Seq_IMR90_Human1.03679139
116EZH2_22144423_ChIP-Seq_EOC_Human1.03636384
117MAF_26560356_Chip-Seq_TH2_Human1.02105091
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01434363
119UTX_26944678_Chip-Seq_JUKART_Human1.01140480
120ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01045817
121CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00861566
122MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00765298
123BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00113781
124* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99998593
125WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99506641
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99434018
127MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98425760
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97315472
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96954846
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96111811
131P68_20966046_ChIP-Seq_HELA_Human0.95462349
132TET1_21451524_ChIP-Seq_MESCs_Mouse0.95143832
133GATA3_24758297_ChIP-Seq_MCF-7_Human0.94765155
134SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94461149
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.94112203
136KLF5_25053715_ChIP-Seq_YYC3_Human0.94047336
137TET1_21490601_ChIP-Seq_MESCs_Mouse0.93002094
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91976115
139SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91780834
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91695177
141KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90828736
142KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90828736
143KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90828736
144* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90788750
145TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90618704
146* LXR_22292898_ChIP-Seq_THP-1_Human0.90584851
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.90054120
148NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89256546
149* TP63_22573176_ChIP-Seq_HFKS_Human0.88108806
150* SMC4_20622854_ChIP-Seq_HELA_Human0.87768070
151KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87606581
152SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87335606
153RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87259352
154FOXP1_21924763_ChIP-Seq_HESCs_Human0.84923056
155TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.84466815
156PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84331164
157YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83831795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.40746117
2MP0002877_abnormal_melanocyte_morpholog4.29252973
3MP0003111_abnormal_nucleus_morphology3.37764980
4MP0005220_abnormal_exocrine_pancreas3.27446592
5MP0009780_abnormal_chondrocyte_physiolo3.12866608
6MP0000013_abnormal_adipose_tissue2.77585454
7MP0008057_abnormal_DNA_replication2.71590691
8MP0001944_abnormal_pancreas_morphology2.70665136
9MP0010234_abnormal_vibrissa_follicle2.67547007
10MP0002693_abnormal_pancreas_physiology2.64390715
11MP0010094_abnormal_chromosome_stability2.62577531
12MP0005451_abnormal_body_composition2.61958667
13MP0002909_abnormal_adrenal_gland2.60381038
14MP0003077_abnormal_cell_cycle2.49587304
15MP0004043_abnormal_pH_regulation2.46843055
16MP0004957_abnormal_blastocyst_morpholog2.44559308
17MP0002396_abnormal_hematopoietic_system2.40587723
18MP0000678_abnormal_parathyroid_gland2.33789032
19MP0003705_abnormal_hypodermis_morpholog2.24507330
20MP0000003_abnormal_adipose_tissue2.22600449
21MP0003566_abnormal_cell_adhesion2.19326290
22MP0004264_abnormal_extraembryonic_tissu2.16425703
23MP0006072_abnormal_retinal_apoptosis2.09824828
24MP0002234_abnormal_pharynx_morphology2.07380493
25MP0004808_abnormal_hematopoietic_stem2.03829125
26MP0000350_abnormal_cell_proliferation2.01747738
27MP0001348_abnormal_lacrimal_gland1.95139399
28MP0002653_abnormal_ependyma_morphology1.92370059
29MP0004233_abnormal_muscle_weight1.84615963
30MP0003119_abnormal_digestive_system1.79759068
31MP0001672_abnormal_embryogenesis/_devel1.72370432
32MP0005380_embryogenesis_phenotype1.72370432
33MP0008961_abnormal_basal_metabolism1.71234559
34MP0003984_embryonic_growth_retardation1.67589086
35MP0001666_abnormal_nutrient_absorption1.66575324
36MP0005409_darkened_coat_color1.64695678
37MP0003183_abnormal_peptide_metabolism1.63916496
38MP0010030_abnormal_orbit_morphology1.62622825
39MP0002080_prenatal_lethality1.59249350
40MP0004858_abnormal_nervous_system1.57409535
41MP0008932_abnormal_embryonic_tissue1.57048881
42MP0002088_abnormal_embryonic_growth/wei1.56997507
43MP0003122_maternal_imprinting1.55438634
44MP0003300_gastrointestinal_ulcer1.55165818
45MP0001915_intracranial_hemorrhage1.53816432
46MP0010352_gastrointestinal_tract_polyps1.53566058
47MP0003890_abnormal_embryonic-extraembry1.50160253
48MP0002086_abnormal_extraembryonic_tissu1.49846581
49MP0003123_paternal_imprinting1.49155943
50MP0001984_abnormal_olfaction1.49141325
51MP0002896_abnormal_bone_mineralization1.48757381
52MP0000566_synostosis1.47087981
53MP0010307_abnormal_tumor_latency1.45726645
54MP0002089_abnormal_postnatal_growth/wei1.44274354
55MP0008789_abnormal_olfactory_epithelium1.42853321
56MP0003656_abnormal_erythrocyte_physiolo1.41885440
57MP0000462_abnormal_digestive_system1.40902809
58MP0000537_abnormal_urethra_morphology1.40357374
59MP0008007_abnormal_cellular_replicative1.39523206
60MP0000613_abnormal_salivary_gland1.35989442
61MP0003091_abnormal_cell_migration1.33750318
62MP0005621_abnormal_cell_physiology1.33198287
63MP0003195_calcinosis1.33024307
64MP0005076_abnormal_cell_differentiation1.32776615
65MP0005083_abnormal_biliary_tract1.30456098
66MP0005394_taste/olfaction_phenotype1.27372020
67MP0005499_abnormal_olfactory_system1.27372020
68MP0001299_abnormal_eye_distance/1.27271317
69MP0003763_abnormal_thymus_physiology1.22804645
70MP0003453_abnormal_keratinocyte_physiol1.22663603
71MP0002078_abnormal_glucose_homeostasis1.21049530
72MP0003045_fibrosis1.18723299
73MP0003115_abnormal_respiratory_system1.17076372
74MP0000313_abnormal_cell_death1.16207837
75MP0002928_abnormal_bile_duct1.13576076
76MP0000733_abnormal_muscle_development1.09199993
77MP0005501_abnormal_skin_physiology1.09046938
78MP0010386_abnormal_urinary_bladder1.08636696
79MP0003172_abnormal_lysosome_physiology1.08408542
80MP0008260_abnormal_autophagy1.08218358
81MP0005379_endocrine/exocrine_gland_phen1.08212651
82MP0009278_abnormal_bone_marrow1.06998557
83MP0000631_abnormal_neuroendocrine_gland1.06415101
84MP0005384_cellular_phenotype1.05727915
85MP0009703_decreased_birth_body1.05196584
86MP0000428_abnormal_craniofacial_morphol1.02868061
87MP0000703_abnormal_thymus_morphology1.02406000
88MP0006054_spinal_hemorrhage1.01628300
89MP0000858_altered_metastatic_potential1.01522073
90MP0005375_adipose_tissue_phenotype1.00398958
91MP0003315_abnormal_perineum_morphology0.99414390
92MP0005666_abnormal_adipose_tissue0.98722659
93MP0001661_extended_life_span0.98614850
94MP0009672_abnormal_birth_weight0.98223020
95MP0003868_abnormal_feces_composition0.98184570
96MP0000490_abnormal_crypts_of0.97304289
97MP0002084_abnormal_developmental_patter0.97154438
98MP0005187_abnormal_penis_morphology0.96784749
99MP0010678_abnormal_skin_adnexa0.96676251
100MP0004270_analgesia0.96329669
101MP0001849_ear_inflammation0.96305592
102MP0008058_abnormal_DNA_repair0.96224853
103MP0005084_abnormal_gallbladder_morpholo0.95339943
104MP0009379_abnormal_foot_pigmentation0.95222375
105MP0002837_dystrophic_cardiac_calcinosis0.94881058
106MP0002166_altered_tumor_susceptibility0.93145479
107MP0005623_abnormal_meninges_morphology0.92782170
108MP0001346_abnormal_lacrimal_gland0.92477946
109MP0002938_white_spotting0.92452080
110MP0000534_abnormal_ureter_morphology0.92398728
111MP0003959_abnormal_lean_body0.92172556
112MP0003943_abnormal_hepatobiliary_system0.91422118
113MP0001293_anophthalmia0.90274147
114MP0002060_abnormal_skin_morphology0.89018162
115MP0005058_abnormal_lysosome_morphology0.89006416
116MP0004272_abnormal_basement_membrane0.88992280
117MP0009384_cardiac_valve_regurgitation0.88352894
118MP0005645_abnormal_hypothalamus_physiol0.87107677
119MP0003942_abnormal_urinary_system0.86074076
120MP0008438_abnormal_cutaneous_collagen0.85830565
121MP0000467_abnormal_esophagus_morphology0.84956834
122MP0002019_abnormal_tumor_incidence0.84873249
123MP0001873_stomach_inflammation0.83952835
124MP0008877_abnormal_DNA_methylation0.82563759
125MP0005646_abnormal_pituitary_gland0.82252145
126MP0004133_heterotaxia0.82108636
127MP0004197_abnormal_fetal_growth/weight/0.81673300
128MP0009053_abnormal_anal_canal0.81453393
129MP0003385_abnormal_body_wall0.80669163
130MP0003861_abnormal_nervous_system0.80084536
131MP0003953_abnormal_hormone_level0.79812130
132MP0001765_abnormal_ion_homeostasis0.77740715
133MP0002925_abnormal_cardiovascular_devel0.77493567
134MP0001286_abnormal_eye_development0.76793583
135MP0002249_abnormal_larynx_morphology0.76636817
136MP0010630_abnormal_cardiac_muscle0.76594844
137MP0002398_abnormal_bone_marrow0.76155688
138MP0009333_abnormal_splenocyte_physiolog0.76114076
139MP0004185_abnormal_adipocyte_glucose0.75523852
140MP0000432_abnormal_head_morphology0.73407326
141MP0002970_abnormal_white_adipose0.73321563
142MP0002085_abnormal_embryonic_tissue0.73295776
143MP0000762_abnormal_tongue_morphology0.72157882
144MP0009931_abnormal_skin_appearance0.71470461
145MP0002009_preneoplasia0.70853392
146MP0005257_abnormal_intraocular_pressure0.69778215
147MP0003121_genomic_imprinting0.68822476
148MP0002233_abnormal_nose_morphology0.67865008
149MP0002638_abnormal_pupillary_reflex0.67334962
150MP0001270_distended_abdomen0.66830554
151MP0003935_abnormal_craniofacial_develop0.66352294
152MP0002751_abnormal_autonomic_nervous0.65464463
153MP0003693_abnormal_embryo_hatching0.62861759
154MP0002697_abnormal_eye_size0.62416884
155MP0002092_abnormal_eye_morphology0.62366087
156MP0001730_embryonic_growth_arrest0.62336603
157MP0003329_amyloid_beta_deposits0.62099123
158MP0001664_abnormal_digestion0.61330782
159MP0001485_abnormal_pinna_reflex0.60862708
160MP0002177_abnormal_outer_ear0.60813962
161MP0000371_diluted_coat_color0.59226247
162MP0001697_abnormal_embryo_size0.58708075
163MP0002098_abnormal_vibrissa_morphology0.58552163
164MP0005408_hypopigmentation0.58124299
165MP0000470_abnormal_stomach_morphology0.57473793

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.42435718
2Hypoglycemic seizures (HP:0002173)4.90249302
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.36746270
4Symptomatic seizures (HP:0011145)4.04466990
5Abnormality of endocrine pancreas physiology (HP:0012093)3.57808970
6Abnormality of the pancreatic islet cells (HP:0006476)3.57808970
7Abnormal pancreas size (HP:0012094)3.52121683
8Hypoglycemic coma (HP:0001325)3.47462117
9Large for gestational age (HP:0001520)3.46823362
10Hyperacusis (HP:0010780)3.44546002
11Hyperglycemia (HP:0003074)3.38724592
12Asymmetry of the thorax (HP:0001555)3.18644517
13Ankyloglossia (HP:0010296)3.08545903
14Pancreatic islet-cell hyperplasia (HP:0004510)3.05823447
15Insulin-resistant diabetes mellitus (HP:0000831)3.03216255
16Congenital glaucoma (HP:0001087)3.01026683
17Deep venous thrombosis (HP:0002625)2.96478422
18Overlapping toe (HP:0001845)2.88935824
19Flat acetabular roof (HP:0003180)2.78297926
20Deep palmar crease (HP:0006191)2.77812925
21Ketoacidosis (HP:0001993)2.74164531
22Missing ribs (HP:0000921)2.73735561
23Heterotopia (HP:0002282)2.65744952
24Hand muscle atrophy (HP:0009130)2.63018330
25Ulnar bowing (HP:0003031)2.58047563
26Protrusio acetabuli (HP:0003179)2.57647030
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55993927
28Abnormality of calcium-phosphate metabolism (HP:0100530)2.54433814
29Subacute progressive viral hepatitis (HP:0006572)2.51782032
30Broad face (HP:0000283)2.51765375
31Increased nuchal translucency (HP:0010880)2.51663601
32Exocrine pancreatic insufficiency (HP:0001738)2.51587781
33Late onset (HP:0003584)2.47747825
34Dysmetric saccades (HP:0000641)2.41516262
35Hypoplastic labia majora (HP:0000059)2.40471397
36Unilateral renal agenesis (HP:0000122)2.39601944
37Hypercortisolism (HP:0001578)2.38509131
38Chromsome breakage (HP:0040012)2.33903482
39Broad palm (HP:0001169)2.33890492
40Disproportionate tall stature (HP:0001519)2.30131666
41Distal upper limb amyotrophy (HP:0007149)2.28534644
42Upper limb amyotrophy (HP:0009129)2.28534644
43Dislocated radial head (HP:0003083)2.27552936
44Small epiphyses (HP:0010585)2.27148138
45Hyperparathyroidism (HP:0000843)2.26760314
46Dysostosis multiplex (HP:0000943)2.25614064
47Buphthalmos (HP:0000557)2.25436806
48Abnormality of the fingertips (HP:0001211)2.23388800
49Long palpebral fissure (HP:0000637)2.21558461
50Decreased circulating renin level (HP:0003351)2.20506521
51Abnormality of oral frenula (HP:0000190)2.17855013
52Reticulocytosis (HP:0001923)2.17159656
53Long eyelashes (HP:0000527)2.14822340
54Biconcave vertebral bodies (HP:0004586)2.14438489
55Degeneration of anterior horn cells (HP:0002398)2.14153058
56Abnormality of the anterior horn cell (HP:0006802)2.14153058
57Thoracolumbar scoliosis (HP:0002944)2.14130030
58Deviation of the thumb (HP:0009603)2.12698982
59Achilles tendon contracture (HP:0001771)2.11147466
60Abnormality of the labia majora (HP:0012881)2.11107452
61Type II lissencephaly (HP:0007260)2.10937166
62Dysautonomia (HP:0002459)2.10324406
63Viral hepatitis (HP:0006562)2.09460723
64Abnormality of the radial head (HP:0003995)2.08857662
65Gout (HP:0001997)2.08262923
66Syringomyelia (HP:0003396)2.06760843
67Spinal cord lesions (HP:0100561)2.06760843
68Urinary glycosaminoglycan excretion (HP:0003541)2.05927640
69Mucopolysacchariduria (HP:0008155)2.05927640
70Shallow orbits (HP:0000586)2.04961998
71Urethral obstruction (HP:0000796)2.03375083
72Abnormality of reticulocytes (HP:0004312)2.02690445
73Renal duplication (HP:0000075)2.01998016
74Abnormality of the fovea (HP:0000493)2.01682552
75Insulin resistance (HP:0000855)2.01563230
76Abnormality of the Achilles tendon (HP:0005109)2.00523188
77Uterine leiomyosarcoma (HP:0002891)2.00489249
78Leiomyosarcoma (HP:0100243)2.00489249
79Hypsarrhythmia (HP:0002521)1.99293194
80Macroorchidism (HP:0000053)1.98452458
8111 pairs of ribs (HP:0000878)1.97752892
82Facial hemangioma (HP:0000329)1.96905163
83EEG with generalized epileptiform discharges (HP:0011198)1.96647620
84Advanced eruption of teeth (HP:0006288)1.95351602
85Retinal atrophy (HP:0001105)1.94717501
86Proximal placement of thumb (HP:0009623)1.92366431
87Progressive muscle weakness (HP:0003323)1.92293220
88Abnormality of the distal phalanx of the thumb (HP:0009617)1.91108206
89Chronic bronchitis (HP:0004469)1.90315830
90Agitation (HP:0000713)1.88104600
91Epileptiform EEG discharges (HP:0011182)1.87902487
92Progressive external ophthalmoplegia (HP:0000590)1.87879442
93Self-mutilation (HP:0000742)1.87876972
94Hypokalemia (HP:0002900)1.87710849
95Renal cell carcinoma (HP:0005584)1.87221887
96Ependymoma (HP:0002888)1.87168881
97Insidious onset (HP:0003587)1.87085190
98Termporal pattern (HP:0011008)1.87085190
99Patellar dislocation (HP:0002999)1.85366540
100Vertebral compression fractures (HP:0002953)1.84869099
101Abnormal ossification of hand bones (HP:0005921)1.84527976
102Abnormality of the calcaneus (HP:0008364)1.84493568
103Squamous cell carcinoma (HP:0002860)1.84237899
104Abnormality of polysaccharide metabolism (HP:0011012)1.83874125
105Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83874125
106Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83874125
107Abnormal foot bone ossification (HP:0010675)1.83191929
108Testicular neoplasm (HP:0010788)1.82322039
109Abnormality of carpal bone ossification (HP:0006257)1.82039391
110Obstructive sleep apnea (HP:0002870)1.81604806
111Sparse lateral eyebrow (HP:0005338)1.81535484
112Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81420095
113Aplasia/Hypoplasia of the fovea (HP:0008060)1.81194435
114Hypoplasia of the fovea (HP:0007750)1.81194435
115Type II diabetes mellitus (HP:0005978)1.79859529
116Vertebral arch anomaly (HP:0008438)1.79388360
117Back pain (HP:0003418)1.77758266
118Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77715627
119Arnold-Chiari malformation (HP:0002308)1.76299440
120Mitral regurgitation (HP:0001653)1.74942180
121Selective tooth agenesis (HP:0001592)1.74773570
122High anterior hairline (HP:0009890)1.74691561
123Thin bony cortex (HP:0002753)1.74637027
124Abnormality of the humeroradial joint (HP:0100744)1.74145301
125Pseudobulbar signs (HP:0002200)1.73995309
126Retinal dysplasia (HP:0007973)1.73760694
127Orthostatic hypotension (HP:0001278)1.73340119
128Reticulocytopenia (HP:0001896)1.72144332
129Rectal prolapse (HP:0002035)1.71999429
130Cupped ribs (HP:0000887)1.71886428
131Limited elbow extension (HP:0001377)1.71679191
132Elfin facies (HP:0004428)1.71537056
133Bifid tongue (HP:0010297)1.71498776
134Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71132490
135Degeneration of the lateral corticospinal tracts (HP:0002314)1.71132490
136Neoplasm of the heart (HP:0100544)1.71021208
137Anteriorly placed anus (HP:0001545)1.70329925
138Malignant gastrointestinal tract tumors (HP:0006749)1.69621141
139Gastrointestinal carcinoma (HP:0002672)1.69621141
140Pointed chin (HP:0000307)1.69087117
141Metaphyseal cupping (HP:0003021)1.68882127
142Severe short stature (HP:0003510)1.68852463
143Abnormality of the thoracic spine (HP:0100711)1.68841974
144Transitional cell carcinoma of the bladder (HP:0006740)1.67964217
145Obsessive-compulsive behavior (HP:0000722)1.67307295
146Maternal diabetes (HP:0009800)1.66887969
147Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66078015
148Cerebral aneurysm (HP:0004944)1.65576269
149Type I diabetes mellitus (HP:0100651)1.65529871
150Menstrual irregularities (HP:0000858)1.65466849
151Abnormality of dentin (HP:0010299)1.65380016
152Micronodular cirrhosis (HP:0001413)1.64696485
153Overriding aorta (HP:0002623)1.62430582
154Fragile skin (HP:0001030)1.62361755
155Male infertility (HP:0003251)1.59556384
156Broad alveolar ridges (HP:0000187)1.59391035
157Glucose intolerance (HP:0000833)1.59350290
158Broad distal phalanx of finger (HP:0009836)1.59077809
159Cerebral inclusion bodies (HP:0100314)1.58806518
160Natal tooth (HP:0000695)1.58613373
161Papilledema (HP:0001085)1.58293072
162Visual hallucinations (HP:0002367)1.58016736
163Trigonocephaly (HP:0000243)1.57978506
164Wide nose (HP:0000445)1.57964976
165Posterior subcapsular cataract (HP:0007787)1.56917471
166Abnormality of cochlea (HP:0000375)1.56836356
167Labial hypoplasia (HP:0000066)1.56620044
168Wormian bones (HP:0002645)1.56308327
169Nephroblastoma (Wilms tumor) (HP:0002667)1.56150861
170Relative macrocephaly (HP:0004482)1.55756604
171Insomnia (HP:0100785)1.55691765
172Ventricular fibrillation (HP:0001663)1.55582291
173Decreased subcutaneous fat (HP:0001002)1.55328573
174Aplasia/Hypoplasia affecting the retina (HP:0008061)1.54511872
175Abnormality of the distal phalanges of the toes (HP:0010182)1.53599290
176Premature rupture of membranes (HP:0001788)1.53089995
177Abnormality of the intrinsic pathway (HP:0010989)1.52320482
178Restlessness (HP:0000711)1.51587105
179Abdominal distention (HP:0003270)1.51425016
180Bladder diverticulum (HP:0000015)1.50008510
181Abnormality of potassium homeostasis (HP:0011042)1.49553017
182Astrocytoma (HP:0009592)1.49398553
183Abnormality of the astrocytes (HP:0100707)1.49398553
184Short nail (HP:0001799)1.48934311
185Abnormality of subcutaneous fat tissue (HP:0001001)1.48714598
186Bony spicule pigmentary retinopathy (HP:0007737)1.48604729
187Hypotension (HP:0002615)1.48595436
188Bronchomalacia (HP:0002780)1.46592466
189Abnormality of the salivary glands (HP:0010286)1.45960750
190Absent eyelashes (HP:0000561)1.44900757
191Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.44503873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.00365393
2MAPK153.95066740
3PASK3.92909343
4SMG13.75086557
5PRKD33.47171309
6TRIB33.12524256
7MAP3K23.05896587
8PRPF4B2.94302854
9SCYL22.75816178
10PKN22.38140163
11IRAK32.16386342
12HIPK22.10514930
13WNK42.08455177
14PDGFRA1.94466943
15NME21.91048540
16ERN11.89898260
17MAP2K21.78517511
18LATS11.68076470
19CDK121.64439884
20CDC71.59288766
21FRK1.56546285
22MAP3K131.52353723
23NTRK11.51083269
24SIK21.47596281
25CDK41.44560243
26BCKDK1.42628483
27MET1.38301419
28CAMKK21.37929608
29KSR21.37776986
30MST1R1.35654929
31DYRK1B1.33125740
32EPHA21.32975053
33PTK61.32589946
34PTK21.31520184
35NTRK31.29362343
36MTOR1.26305429
37ICK1.26221830
38EPHA31.24398662
39RET1.23426632
40FER1.22307770
41MAP3K11.18245916
42TYRO31.17043724
43TAOK21.13350867
44MAP3K81.13034769
45PAK31.11982442
46SIK11.11215453
47WNK31.10334435
48UHMK11.10084692
49TTN1.09676326
50DDR21.08248500
51RPS6KB21.08132037
52BUB11.06703660
53CDK71.06265096
54EIF2AK11.05122928
55MAPK111.04516221
56CAMKK11.00901645
57PAK60.99430619
58PDK30.96621631
59PDK40.96621631
60WNK10.96517903
61PAK20.96340626
62BRSK20.94055698
63MAP2K30.92970806
64FLT30.91784433
65TAOK30.91030410
66EPHB10.91002042
67CDC42BPA0.90491325
68BRD40.90453237
69RIPK10.87124854
70CDK80.84840143
71PDGFRB0.82951908
72IRAK10.82379498
73CHEK20.81008082
74CDK60.80481843
75LATS20.79562628
76PAK40.79476370
77WEE10.77661631
78MAP3K90.75538955
79MAP4K10.74535034
80IRAK20.74470206
81CDK90.69543147
82STK40.69033252
83ALK0.68927916
84DYRK1A0.67271057
85BRAF0.66525760
86ATR0.65753159
87MARK20.65465473
88MAP2K10.65367347
89PRKD20.64116743
90IRAK40.64094145
91CLK10.64043458
92BMX0.63351753
93PBK0.62693303
94FGFR20.59259952
95EIF2AK30.58499952
96FGFR10.57911329
97MAP3K140.57784714
98CAMK1D0.56917963
99NEK20.56761225
100CAMK1G0.55999414
101CDK10.55765645
102PRKCH0.55750075
103PRKD10.55709909
104PRKCI0.54747521
105DYRK30.53870974
106YES10.52949275
107MAP3K100.52846134
108CSNK1E0.51015148
109PDPK10.50875032
110PIK3CG0.50163602
111AURKB0.49840745
112CAMK2B0.49115323
113ERBB40.48900887
114AURKA0.48632622
115PRKDC0.48384734
116SRPK10.46342281
117PDK20.45972312
118STK38L0.45756008
119MELK0.45383611
120EEF2K0.44974546
121NLK0.43550414
122CAMK2D0.42710881
123TSSK60.42415348
124MAP3K30.41061117
125ARAF0.40631060
126MAP3K70.39596419
127MAPK100.39005722
128TAF10.38988077
129GSK3A0.37343277
130RPS6KA10.37204677
131STK100.36695091
132AKT20.36662389
133BRSK10.36470110
134LRRK20.36109965
135TESK10.35537456
136ATM0.35249403
137CHEK10.34803065
138RPS6KL10.34759009
139RPS6KC10.34759009
140CSNK1A10.32896211
141TAOK10.32495619
142CDK50.32163835
143PHKG10.32114262
144PHKG20.32114262
145TTK0.32095315
146MAPK140.31635448
147MARK30.30828427
148PNCK0.30001147
149FGFR40.29383894
150CSNK1A1L0.28086889
151CDK20.27569741
152FGFR30.27522585

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.43626232
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.35783100
3Protein export_Homo sapiens_hsa030603.30657331
4Pancreatic secretion_Homo sapiens_hsa049723.17969988
5Insulin secretion_Homo sapiens_hsa049112.85245143
6DNA replication_Homo sapiens_hsa030302.65569580
7Chronic myeloid leukemia_Homo sapiens_hsa052202.34329007
8Non-small cell lung cancer_Homo sapiens_hsa052232.21994515
9Cell cycle_Homo sapiens_hsa041102.15161308
10Protein digestion and absorption_Homo sapiens_hsa049742.03765282
11N-Glycan biosynthesis_Homo sapiens_hsa005102.00259953
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93168370
13mRNA surveillance pathway_Homo sapiens_hsa030151.84885961
14Sulfur metabolism_Homo sapiens_hsa009201.81004267
15Cocaine addiction_Homo sapiens_hsa050301.78285179
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76793954
17Vibrio cholerae infection_Homo sapiens_hsa051101.76422418
18Type II diabetes mellitus_Homo sapiens_hsa049301.73680078
19Pancreatic cancer_Homo sapiens_hsa052121.70638700
20Spliceosome_Homo sapiens_hsa030401.67926355
21Small cell lung cancer_Homo sapiens_hsa052221.65564271
22B cell receptor signaling pathway_Homo sapiens_hsa046621.65097359
23MicroRNAs in cancer_Homo sapiens_hsa052061.62727734
24Amphetamine addiction_Homo sapiens_hsa050311.58517742
25Acute myeloid leukemia_Homo sapiens_hsa052211.50561662
26Lysine degradation_Homo sapiens_hsa003101.49785850
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41794828
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39136536
29Other glycan degradation_Homo sapiens_hsa005111.36728976
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36193611
31Estrogen signaling pathway_Homo sapiens_hsa049151.27451489
32Viral carcinogenesis_Homo sapiens_hsa052031.26497717
33Biosynthesis of amino acids_Homo sapiens_hsa012301.23339829
34Nucleotide excision repair_Homo sapiens_hsa034201.22991248
35Colorectal cancer_Homo sapiens_hsa052101.22707928
36Selenocompound metabolism_Homo sapiens_hsa004501.22359633
37Base excision repair_Homo sapiens_hsa034101.21611014
38Fat digestion and absorption_Homo sapiens_hsa049751.19024582
39Glucagon signaling pathway_Homo sapiens_hsa049221.18054622
40One carbon pool by folate_Homo sapiens_hsa006701.17609992
41Olfactory transduction_Homo sapiens_hsa047401.16380801
42Thyroid hormone synthesis_Homo sapiens_hsa049181.15349174
43Dorso-ventral axis formation_Homo sapiens_hsa043201.13866388
44Mismatch repair_Homo sapiens_hsa034301.13266470
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13149293
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11349789
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09710395
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07772832
49Long-term potentiation_Homo sapiens_hsa047201.07442260
50HTLV-I infection_Homo sapiens_hsa051661.07429063
51Proteoglycans in cancer_Homo sapiens_hsa052051.07309219
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06626508
53Hepatitis B_Homo sapiens_hsa051611.05706421
54Dopaminergic synapse_Homo sapiens_hsa047281.05616688
55Non-homologous end-joining_Homo sapiens_hsa034501.03943890
56Folate biosynthesis_Homo sapiens_hsa007901.00467410
57Pentose phosphate pathway_Homo sapiens_hsa000300.93808870
58Bladder cancer_Homo sapiens_hsa052190.91906107
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90079296
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89112884
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88651119
62Circadian entrainment_Homo sapiens_hsa047130.88579573
63Choline metabolism in cancer_Homo sapiens_hsa052310.88523448
64Hedgehog signaling pathway_Homo sapiens_hsa043400.87828499
65mTOR signaling pathway_Homo sapiens_hsa041500.87785839
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87054475
67Circadian rhythm_Homo sapiens_hsa047100.85959808
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85167426
69Tight junction_Homo sapiens_hsa045300.83849919
70Alcoholism_Homo sapiens_hsa050340.83147477
71Apoptosis_Homo sapiens_hsa042100.82992973
72Renin secretion_Homo sapiens_hsa049240.81877214
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81135892
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80478623
75Ribosome_Homo sapiens_hsa030100.80475311
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80162040
77Lysosome_Homo sapiens_hsa041420.80090547
78HIF-1 signaling pathway_Homo sapiens_hsa040660.78490056
79Type I diabetes mellitus_Homo sapiens_hsa049400.78251896
80Melanogenesis_Homo sapiens_hsa049160.77420976
81Adherens junction_Homo sapiens_hsa045200.76846749
82Insulin resistance_Homo sapiens_hsa049310.74598164
83Epstein-Barr virus infection_Homo sapiens_hsa051690.74397943
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73221543
85T cell receptor signaling pathway_Homo sapiens_hsa046600.73000704
86Cholinergic synapse_Homo sapiens_hsa047250.72830756
87FoxO signaling pathway_Homo sapiens_hsa040680.72623127
88Hippo signaling pathway_Homo sapiens_hsa043900.72393981
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72157611
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72034707
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71823785
92Prostate cancer_Homo sapiens_hsa052150.70456738
93Glycerolipid metabolism_Homo sapiens_hsa005610.69863473
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68383114
95GABAergic synapse_Homo sapiens_hsa047270.68296504
96Vitamin B6 metabolism_Homo sapiens_hsa007500.68249010
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67771472
98Herpes simplex infection_Homo sapiens_hsa051680.67478227
99Thyroid cancer_Homo sapiens_hsa052160.67257119
100p53 signaling pathway_Homo sapiens_hsa041150.67236871
101cAMP signaling pathway_Homo sapiens_hsa040240.66028536
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65954306
103Gastric acid secretion_Homo sapiens_hsa049710.65875834
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65044137
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.64369884
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64229616
107Pathways in cancer_Homo sapiens_hsa052000.63973070
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62101658
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.61037333
110Gap junction_Homo sapiens_hsa045400.61009703
111Taste transduction_Homo sapiens_hsa047420.60791121
112Notch signaling pathway_Homo sapiens_hsa043300.60720472
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.60524534
114Insulin signaling pathway_Homo sapiens_hsa049100.60012205
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59973814
116Prion diseases_Homo sapiens_hsa050200.59936738
117Fructose and mannose metabolism_Homo sapiens_hsa000510.59790190
118Melanoma_Homo sapiens_hsa052180.59480671
119Endometrial cancer_Homo sapiens_hsa052130.57530743
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.57283802
121Phototransduction_Homo sapiens_hsa047440.57193164
122Glioma_Homo sapiens_hsa052140.57055443
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.56926207
124Influenza A_Homo sapiens_hsa051640.55856643
125Oocyte meiosis_Homo sapiens_hsa041140.55480390
126GnRH signaling pathway_Homo sapiens_hsa049120.54146917
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53523585
128Synaptic vesicle cycle_Homo sapiens_hsa047210.53325242
129Arginine biosynthesis_Homo sapiens_hsa002200.53310234
130Inositol phosphate metabolism_Homo sapiens_hsa005620.52598817
131Basal cell carcinoma_Homo sapiens_hsa052170.52063602
132RNA transport_Homo sapiens_hsa030130.51696372
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.51158886
134Wnt signaling pathway_Homo sapiens_hsa043100.51128125
135VEGF signaling pathway_Homo sapiens_hsa043700.50286923
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.50235708
137Serotonergic synapse_Homo sapiens_hsa047260.50137110
138Salivary secretion_Homo sapiens_hsa049700.49944932
139Axon guidance_Homo sapiens_hsa043600.49718600
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49657614
141AMPK signaling pathway_Homo sapiens_hsa041520.49608302
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48839999
143Morphine addiction_Homo sapiens_hsa050320.48770289
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.48547002
145Renal cell carcinoma_Homo sapiens_hsa052110.48331831
146Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48185189
147Hepatitis C_Homo sapiens_hsa051600.47576578
148Glutamatergic synapse_Homo sapiens_hsa047240.47235493
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45891469
150Sphingolipid metabolism_Homo sapiens_hsa006000.45697488
151Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43821937
152ErbB signaling pathway_Homo sapiens_hsa040120.43111684
153Prolactin signaling pathway_Homo sapiens_hsa049170.42003399
154Neurotrophin signaling pathway_Homo sapiens_hsa047220.42000701
155Galactose metabolism_Homo sapiens_hsa000520.41562210
156Focal adhesion_Homo sapiens_hsa045100.40571551
157ECM-receptor interaction_Homo sapiens_hsa045120.40114990

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