QTRT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.77254509
2maturation of SSU-rRNA (GO:0030490)5.28305750
3formation of translation preinitiation complex (GO:0001731)4.88066934
4purine deoxyribonucleotide catabolic process (GO:0009155)4.86851303
5iron-sulfur cluster assembly (GO:0016226)4.85249820
6metallo-sulfur cluster assembly (GO:0031163)4.85249820
7DNA deamination (GO:0045006)4.72222911
8DNA strand elongation involved in DNA replication (GO:0006271)4.59261159
9telomere maintenance via semi-conservative replication (GO:0032201)4.49503273
10nucleobase biosynthetic process (GO:0046112)4.48679781
11DNA strand elongation (GO:0022616)4.38934498
12base-excision repair, AP site formation (GO:0006285)4.26537420
13purine nucleobase biosynthetic process (GO:0009113)4.24468070
14ribosome biogenesis (GO:0042254)4.23229491
15negative regulation of B cell apoptotic process (GO:0002903)4.17780888
16viral transcription (GO:0019083)4.14786672
17translational termination (GO:0006415)4.14493238
18regulation of mitochondrial translation (GO:0070129)4.14406003
19ribosomal small subunit biogenesis (GO:0042274)4.13909215
20deoxyribonucleotide catabolic process (GO:0009264)4.09082567
21ribonucleoprotein complex biogenesis (GO:0022613)4.06897830
22DNA replication initiation (GO:0006270)4.06559234
23protein complex biogenesis (GO:0070271)4.03221142
24pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.02324454
25ubiquinone biosynthetic process (GO:0006744)3.99654636
26viral mRNA export from host cell nucleus (GO:0046784)3.97428221
27DNA replication checkpoint (GO:0000076)3.96955187
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.95821844
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.95821844
30purine deoxyribonucleotide metabolic process (GO:0009151)3.94949035
31telomere maintenance via recombination (GO:0000722)3.93642915
32regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.93331096
33pseudouridine synthesis (GO:0001522)3.91233605
34phosphatidylglycerol biosynthetic process (GO:0006655)3.91017172
35IMP biosynthetic process (GO:0006188)3.88023307
36mitochondrial respiratory chain complex assembly (GO:0033108)3.85100722
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.83360487
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.83360487
39NADH dehydrogenase complex assembly (GO:0010257)3.83360487
40mannosylation (GO:0097502)3.80383065
41translational elongation (GO:0006414)3.78284483
42UV protection (GO:0009650)3.77424304
43ribosomal large subunit biogenesis (GO:0042273)3.77340264
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77303571
45deoxyribose phosphate catabolic process (GO:0046386)3.75692390
46response to misfolded protein (GO:0051788)3.75167486
47translational initiation (GO:0006413)3.74808594
48ribosome assembly (GO:0042255)3.73745470
49rRNA processing (GO:0006364)3.71217111
50spliceosomal snRNP assembly (GO:0000387)3.67333207
51proteasome assembly (GO:0043248)3.66739983
52cotranslational protein targeting to membrane (GO:0006613)3.66491438
53protein targeting to ER (GO:0045047)3.64828393
54mitotic recombination (GO:0006312)3.59977162
55maturation of 5.8S rRNA (GO:0000460)3.59837157
56telomere maintenance via telomere lengthening (GO:0010833)3.59264223
57rRNA modification (GO:0000154)3.58884214
58rRNA metabolic process (GO:0016072)3.58222601
59deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.55499786
60respiratory chain complex IV assembly (GO:0008535)3.55417729
61protoporphyrinogen IX biosynthetic process (GO:0006782)3.53353411
62mitotic metaphase plate congression (GO:0007080)3.51827600
63DNA unwinding involved in DNA replication (GO:0006268)3.50303234
64cytochrome complex assembly (GO:0017004)3.49876082
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.46731517
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45905841
67transcription elongation from RNA polymerase III promoter (GO:0006385)3.44391204
68termination of RNA polymerase III transcription (GO:0006386)3.44391204
69establishment of protein localization to endoplasmic reticulum (GO:0072599)3.44164062
70CENP-A containing nucleosome assembly (GO:0034080)3.43802240
71protein localization to endoplasmic reticulum (GO:0070972)3.43422241
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.42776906
73quinone biosynthetic process (GO:1901663)3.41501899
742-deoxyribonucleotide metabolic process (GO:0009394)3.40976440
75chromatin remodeling at centromere (GO:0031055)3.38928675
76transcription-coupled nucleotide-excision repair (GO:0006283)3.37493720
77IMP metabolic process (GO:0046040)3.36041812
78ubiquinone metabolic process (GO:0006743)3.34431091
79folic acid-containing compound biosynthetic process (GO:0009396)3.34431019
80translation (GO:0006412)3.33308012
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32176447
82mitotic nuclear envelope disassembly (GO:0007077)3.31340243
83cellular protein complex disassembly (GO:0043624)3.30308004
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29866885
85cellular response to interferon-beta (GO:0035458)3.29748029
86protein localization to kinetochore (GO:0034501)3.28833544
87regulation of nuclear cell cycle DNA replication (GO:0033262)3.28131614
88pyrimidine nucleotide catabolic process (GO:0006244)3.28062567
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27848659
90folic acid metabolic process (GO:0046655)3.27658216
91somatic hypermutation of immunoglobulin genes (GO:0016446)3.26317955
92somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26317955
93peptidyl-arginine omega-N-methylation (GO:0035247)3.25410554
94mitochondrial RNA metabolic process (GO:0000959)3.21963260
95viral life cycle (GO:0019058)3.21948283
96cellular component biogenesis (GO:0044085)3.21847256
97preassembly of GPI anchor in ER membrane (GO:0016254)3.21598581
98valine metabolic process (GO:0006573)3.20272970
99glutathione biosynthetic process (GO:0006750)3.18605984
100branched-chain amino acid catabolic process (GO:0009083)3.18399780
101GDP-mannose metabolic process (GO:0019673)3.18245145
102negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16609083
103negative regulation of ligase activity (GO:0051352)3.16609083
104spliceosomal complex assembly (GO:0000245)3.16377561
105transcription from RNA polymerase I promoter (GO:0006360)3.15074394
106cullin deneddylation (GO:0010388)3.14894350
107tRNA methylation (GO:0030488)3.14626543
108transcription elongation from RNA polymerase I promoter (GO:0006362)3.13488329
109lipopolysaccharide biosynthetic process (GO:0009103)3.12819552
110exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10971435
1117-methylguanosine mRNA capping (GO:0006370)3.10532294
112termination of RNA polymerase I transcription (GO:0006363)3.09963670
113metaphase plate congression (GO:0051310)3.07814510
114nonribosomal peptide biosynthetic process (GO:0019184)3.07208679
115DNA replication-independent nucleosome organization (GO:0034724)3.06963451
116DNA replication-independent nucleosome assembly (GO:0006336)3.06963451
117* tRNA modification (GO:0006400)3.06172082
118histone H2A acetylation (GO:0043968)3.06088220
119nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06085535
120RNA capping (GO:0036260)3.05710393
1217-methylguanosine RNA capping (GO:0009452)3.05710393
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05408801
123protein K6-linked ubiquitination (GO:0085020)3.05163746
124deoxyribose phosphate metabolic process (GO:0019692)3.04071446
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.03631815
126signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.01646249
127signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.01646249
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.01646249
129L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01302022
130membrane disassembly (GO:0030397)3.00392526
131nuclear envelope disassembly (GO:0051081)3.00392526
132signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00111275
133intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00111275
134positive regulation of histone deacetylation (GO:0031065)2.99712045
135deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.99427148
136protein complex disassembly (GO:0043241)2.99122408
137signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97991129
138signal transduction involved in DNA damage checkpoint (GO:0072422)2.97991129
139DNA replication-dependent nucleosome organization (GO:0034723)2.96797603
140DNA replication-dependent nucleosome assembly (GO:0006335)2.96797603
141* ncRNA processing (GO:0034470)2.96506125
142nuclear-transcribed mRNA catabolic process (GO:0000956)2.95918371
143protein deneddylation (GO:0000338)2.95005834
144histone arginine methylation (GO:0034969)2.94351591
145signal transduction involved in cell cycle checkpoint (GO:0072395)2.93925538
146* ncRNA metabolic process (GO:0034660)2.92952143
147oxidative phosphorylation (GO:0006119)2.90884510
148purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.89590275
149negative regulation of telomere maintenance (GO:0032205)2.89362381
150opioid receptor signaling pathway (GO:0038003)2.88626473
151regulation of B cell apoptotic process (GO:0002902)2.84729414
152branched-chain amino acid metabolic process (GO:0009081)2.84635590
153neurotransmitter catabolic process (GO:0042135)2.83777700
154peptide biosynthetic process (GO:0043043)2.83275745
155energy coupled proton transport, down electrochemical gradient (GO:0015985)2.77321497
156ATP synthesis coupled proton transport (GO:0015986)2.77321497
157response to interferon-beta (GO:0035456)2.77143829
158electron transport chain (GO:0022900)2.75141610
159pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.74548632
160respiratory electron transport chain (GO:0022904)2.74140815
161mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.73812036
162misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.71271884
163chaperone mediated protein folding requiring cofactor (GO:0051085)2.68457668
164negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.67394749
165nucleotide salvage (GO:0043173)2.67214987
166negative regulation of cell cycle arrest (GO:0071157)2.64913210
167peptidyl-histidine modification (GO:0018202)2.63684244
168deoxyribonucleotide metabolic process (GO:0009262)2.62681408
169positive regulation of prostaglandin secretion (GO:0032308)2.61808445
170chaperone-mediated protein transport (GO:0072321)2.60555533
171L-methionine biosynthetic process (GO:0071265)2.59863904
172amino acid salvage (GO:0043102)2.59863904
173L-methionine salvage (GO:0071267)2.59863904
174cardiolipin metabolic process (GO:0032048)2.59625701
175* tRNA processing (GO:0008033)2.57669274
176protoporphyrinogen IX metabolic process (GO:0046501)2.55918390
177heme biosynthetic process (GO:0006783)2.55764257
178alkaloid metabolic process (GO:0009820)2.54446900
179regulation of hydrogen peroxide metabolic process (GO:0010310)2.54258522
180positive regulation of fatty acid transport (GO:2000193)2.53265073
181energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.53169146
182ATP hydrolysis coupled proton transport (GO:0015991)2.53169146
183cellular ketone body metabolic process (GO:0046950)2.53054032
184GPI anchor biosynthetic process (GO:0006506)2.52055530
185positive thymic T cell selection (GO:0045059)2.51233719
186lipopolysaccharide metabolic process (GO:0008653)2.50807684
187autophagic vacuole fusion (GO:0000046)2.50213406
188UTP biosynthetic process (GO:0006228)2.49371713
189negative regulation of DNA-templated transcription, elongation (GO:0032785)2.48462495
190peptidyl-arginine N-methylation (GO:0035246)2.47078868
191peptidyl-arginine methylation (GO:0018216)2.47078868
192female mating behavior (GO:0060180)2.45925203

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.89098527
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.53390900
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85843936
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45009708
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.37143235
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33678881
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.19836413
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19259728
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.14317144
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12762114
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07718146
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01536648
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00978684
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.99693484
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80891423
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.65697695
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57085928
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.50013377
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46973067
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.45307315
21VDR_23849224_ChIP-Seq_CD4+_Human2.42935094
22XRN2_22483619_ChIP-Seq_HELA_Human2.39240396
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32871944
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24232370
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21377549
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19595658
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19067481
28* P68_20966046_ChIP-Seq_HELA_Human2.18268997
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18053805
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17718947
31ELF1_20517297_ChIP-Seq_JURKAT_Human2.09132746
32* BCL6_27268052_Chip-Seq_Bcells_Human2.07924044
33LXR_22292898_ChIP-Seq_THP-1_Human2.07413509
34* GABP_19822575_ChIP-Seq_HepG2_Human2.07208734
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06898423
36FOXP3_21729870_ChIP-Seq_TREG_Human2.06624676
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01762934
38TET1_21451524_ChIP-Seq_MESCs_Mouse2.01546316
39DCP1A_22483619_ChIP-Seq_HELA_Human2.01153740
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00002832
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97339868
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.97188996
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95219922
44* TTF2_22483619_ChIP-Seq_HELA_Human1.91245920
45* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89864682
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88709830
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86747621
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84406336
49* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81206360
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.80377606
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79166150
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78761033
53* CIITA_25753668_ChIP-Seq_RAJI_Human1.77283581
54BCOR_27268052_Chip-Seq_Bcells_Human1.73623812
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.72688348
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69967073
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69233037
58* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69054680
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63291995
60ELK1_19687146_ChIP-ChIP_HELA_Human1.62982194
61PHF8_20622854_ChIP-Seq_HELA_Human1.62824441
62* FOXP1_21924763_ChIP-Seq_HESCs_Human1.61755005
63* E2F1_20622854_ChIP-Seq_HELA_Human1.60764910
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.59513063
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.59071171
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.57419905
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.53248452
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52733046
69* CTCF_26484167_Chip-Seq_Bcells_Mouse1.52462397
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51977895
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51860867
72* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51163678
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.50374315
74CTCF_20526341_ChIP-Seq_ESCs_Human1.50098933
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49633441
76KDM5A_27292631_Chip-Seq_BREAST_Human1.47946563
77AR_21909140_ChIP-Seq_LNCAP_Human1.45648715
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44068323
79SA1_27219007_Chip-Seq_Bcells_Human1.44068232
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44057570
81* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.43594117
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42940256
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41856472
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41349157
85* RARB_24833708_ChIP-Seq_LIVER_Mouse1.41294723
86* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41039502
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.40903351
88MYC_22102868_ChIP-Seq_BL_Human1.40515019
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39735086
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38565821
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37613929
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36975344
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36746758
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.36247843
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32256216
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31621928
97SMC4_20622854_ChIP-Seq_HELA_Human1.31488830
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29843480
99* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29116626
100ERA_21632823_ChIP-Seq_H3396_Human1.28660823
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28324572
102MAF_26560356_Chip-Seq_TH2_Human1.28170911
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25053505
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23748597
105CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23675797
106CTCF_27219007_Chip-Seq_Bcells_Human1.22635855
107P300_27268052_Chip-Seq_Bcells_Human1.21194603
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19756995
109SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18666004
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17697236
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15839014
112PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14418705
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13676720
114ETS1_21867929_ChIP-Seq_TH2_Mouse1.12843011
115KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12828952
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11523739
117BP1_19119308_ChIP-ChIP_Hs578T_Human1.11129766
118RARA_24833708_ChIP-Seq_LIVER_Mouse1.10991938
119* TFEB_21752829_ChIP-Seq_HELA_Human1.10279844
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10063306
121ELK3_25401928_ChIP-Seq_HUVEC_Human1.09661856
122PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08711952
123* CTCF_21964334_Chip-Seq_Bcells_Human1.08509149
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08475848
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08434439
126EGR1_19374776_ChIP-ChIP_THP-1_Human1.07212819
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07123071
128* RAC3_21632823_ChIP-Seq_H3396_Human1.06984814
129ELK1_22589737_ChIP-Seq_MCF10A_Human1.06933295
130SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06747206
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06419071
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06290061
133ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06000585
134IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05736705
135TP63_19390658_ChIP-ChIP_HaCaT_Human1.04933861
136* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04369480
137BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04320475
138TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03526416
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03326569
140TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00212841
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00092974
142KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99996258
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97929024
144NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96507142
145VDR_21846776_ChIP-Seq_THP-1_Human0.95880953
146TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93795534
147NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93416868
148SPI1_23547873_ChIP-Seq_NB4_Human0.93247328
149CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93192194
150DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91740931
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.91135173
152CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90091392
153MYC_18940864_ChIP-ChIP_HL60_Human0.87508875
154CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86224799
155OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84126327
156SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82645684
157ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82586442
158CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78768802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.74369183
2MP0004957_abnormal_blastocyst_morpholog4.57207187
3MP0008057_abnormal_DNA_replication4.55481481
4MP0010094_abnormal_chromosome_stability4.54789541
5MP0003111_abnormal_nucleus_morphology4.34382845
6MP0008058_abnormal_DNA_repair4.21429541
7MP0003077_abnormal_cell_cycle4.09606322
8MP0008007_abnormal_cellular_replicative3.03892401
9MP0002396_abnormal_hematopoietic_system2.89220143
10MP0001968_abnormal_touch/_nociception2.80445927
11MP0005083_abnormal_biliary_tract2.80358380
12MP0003172_abnormal_lysosome_physiology2.75766551
13MP0008932_abnormal_embryonic_tissue2.71600472
14MP0004043_abnormal_pH_regulation2.58792705
15MP0002822_catalepsy2.56071582
16MP0008875_abnormal_xenobiotic_pharmacok2.40188753
17MP0003786_premature_aging2.36916834
18MP0003123_paternal_imprinting2.21404120
19MP0009278_abnormal_bone_marrow2.18545168
20MP0001730_embryonic_growth_arrest2.13515946
21MP0000350_abnormal_cell_proliferation2.12776176
22MP0004133_heterotaxia2.09482466
23MP0001905_abnormal_dopamine_level1.94926621
24MP0008877_abnormal_DNA_methylation1.94274877
25MP0000490_abnormal_crypts_of1.94241916
26MP0006292_abnormal_olfactory_placode1.93967246
27MP0002736_abnormal_nociception_after1.92173271
28MP0005645_abnormal_hypothalamus_physiol1.91516290
29MP0005360_urolithiasis1.88779488
30MP0004859_abnormal_synaptic_plasticity1.86704816
31MP0005670_abnormal_white_adipose1.82614242
32MP0002138_abnormal_hepatobiliary_system1.78577217
33MP0008872_abnormal_physiological_respon1.77510262
34MP0004147_increased_porphyrin_level1.76996941
35MP0005365_abnormal_bile_salt1.71926051
36MP0003718_maternal_effect1.70601193
37MP0000003_abnormal_adipose_tissue1.68997972
38MP0003806_abnormal_nucleotide_metabolis1.66817004
39MP0001501_abnormal_sleep_pattern1.65832701
40MP0001502_abnormal_circadian_rhythm1.65182072
41MP0000313_abnormal_cell_death1.62831567
42MP0001873_stomach_inflammation1.62752784
43MP0005380_embryogenesis_phenotype1.61401386
44MP0001672_abnormal_embryogenesis/_devel1.61401386
45MP0001697_abnormal_embryo_size1.61196221
46MP0002080_prenatal_lethality1.58056542
47MP0005646_abnormal_pituitary_gland1.57577357
48MP0010352_gastrointestinal_tract_polyps1.55705012
49MP0005058_abnormal_lysosome_morphology1.52873249
50MP0002733_abnormal_thermal_nociception1.47855974
51MP0003984_embryonic_growth_retardation1.45034321
52MP0001970_abnormal_pain_threshold1.43379575
53MP0002085_abnormal_embryonic_tissue1.42523877
54MP0009745_abnormal_behavioral_response1.41394408
55MP0002088_abnormal_embryonic_growth/wei1.39931910
56MP0005551_abnormal_eye_electrophysiolog1.39729882
57MP0002019_abnormal_tumor_incidence1.39104587
58MP0009333_abnormal_splenocyte_physiolog1.38190581
59MP0004808_abnormal_hematopoietic_stem1.36788346
60MP0002160_abnormal_reproductive_system1.35667070
61MP0003890_abnormal_embryonic-extraembry1.35433829
62MP0002272_abnormal_nervous_system1.35077242
63MP0005075_abnormal_melanosome_morpholog1.34038248
64MP0002064_seizures1.31815853
65MP0000358_abnormal_cell_content/1.31049501
66MP0003763_abnormal_thymus_physiology1.30833595
67MP0002084_abnormal_developmental_patter1.30188983
68MP0001545_abnormal_hematopoietic_system1.29097043
69MP0005397_hematopoietic_system_phenotyp1.29097043
70MP0001529_abnormal_vocalization1.27946614
71MP0005671_abnormal_response_to1.26469537
72MP0002572_abnormal_emotion/affect_behav1.24827951
73MP0002933_joint_inflammation1.20682454
74MP0001293_anophthalmia1.19843822
75MP0009379_abnormal_foot_pigmentation1.19606982
76MP0010030_abnormal_orbit_morphology1.19343823
77MP0002210_abnormal_sex_determination1.19081272
78MP0002086_abnormal_extraembryonic_tissu1.18429578
79MP0001984_abnormal_olfaction1.18303675
80MP0010307_abnormal_tumor_latency1.15008255
81MP0001145_abnormal_male_reproductive1.14418346
82MP0009643_abnormal_urine_homeostasis1.14331187
83MP0002398_abnormal_bone_marrow1.14116249
84MP0000013_abnormal_adipose_tissue1.13764719
85MP0000703_abnormal_thymus_morphology1.12016341
86MP0003567_abnormal_fetal_cardiomyocyte1.09963759
87MP0000689_abnormal_spleen_morphology1.08579799
88MP0003121_genomic_imprinting1.07669274
89MP0009764_decreased_sensitivity_to1.07265403
90MP0003119_abnormal_digestive_system1.06911077
91MP0006072_abnormal_retinal_apoptosis1.06433690
92MP0005174_abnormal_tail_pigmentation1.05790510
93MP0002722_abnormal_immune_system1.05152162
94MP0005423_abnormal_somatic_nervous1.04843852
95MP0005389_reproductive_system_phenotype1.04466686
96MP0002735_abnormal_chemical_nociception1.03894421
97MP0004197_abnormal_fetal_growth/weight/1.03495096
98MP0001486_abnormal_startle_reflex1.03308329
99MP0003186_abnormal_redox_activity1.03102720
100MP0006276_abnormal_autonomic_nervous1.02608451
101MP0005167_abnormal_blood-brain_barrier1.00166292
102MP0003635_abnormal_synaptic_transmissio1.00122392
103MP0003436_decreased_susceptibility_to0.99990040
104MP0002132_abnormal_respiratory_system0.99474265
105MP0005332_abnormal_amino_acid0.99306919
106MP0002938_white_spotting0.99288325
107MP0002876_abnormal_thyroid_physiology0.97502303
108MP0000653_abnormal_sex_gland0.96223355
109MP0003315_abnormal_perineum_morphology0.96217458
110MP0005171_absent_coat_pigmentation0.96217261
111MP0002254_reproductive_system_inflammat0.96183829
112MP0002063_abnormal_learning/memory/cond0.95890892
113MP0001853_heart_inflammation0.95018628
114MP0008569_lethality_at_weaning0.94953320
115MP0006035_abnormal_mitochondrial_morpho0.93790839
116MP0001929_abnormal_gametogenesis0.93442917
117MP0000015_abnormal_ear_pigmentation0.92023046
118MP0002429_abnormal_blood_cell0.91471216
119MP0002638_abnormal_pupillary_reflex0.90955746
120MP0001764_abnormal_homeostasis0.90068189
121MP0002653_abnormal_ependyma_morphology0.88809420
122MP0000858_altered_metastatic_potential0.88449241
123MP0005384_cellular_phenotype0.87365633
124MP0002734_abnormal_mechanical_nocicepti0.86047362
125MP0000371_diluted_coat_color0.85589730
126MP0003941_abnormal_skin_development0.85476453
127MP0009046_muscle_twitch0.85393700
128MP0006036_abnormal_mitochondrial_physio0.84638175
129MP0000751_myopathy0.84223909
130MP0005266_abnormal_metabolism0.83436193
131MP0002095_abnormal_skin_pigmentation0.82182418
132MP0000467_abnormal_esophagus_morphology0.81717914
133MP0002557_abnormal_social/conspecific_i0.80029745
134MP0002148_abnormal_hypersensitivity_rea0.79898047
135MP0001119_abnormal_female_reproductive0.79548555
136MP0003329_amyloid_beta_deposits0.78825926
137MP0001800_abnormal_humoral_immune0.77943357
138MP0008789_abnormal_olfactory_epithelium0.76579805
139MP0000716_abnormal_immune_system0.75108715
140MP0001963_abnormal_hearing_physiology0.75101132
141MP0002075_abnormal_coat/hair_pigmentati0.74286163
142MP0010329_abnormal_lipoprotein_level0.74263131
143MP0009384_cardiac_valve_regurgitation0.74210280
144MP0000537_abnormal_urethra_morphology0.74176198
145MP0005584_abnormal_enzyme/coenzyme_acti0.72909792
146MP0005621_abnormal_cell_physiology0.72531352
147MP0002111_abnormal_tail_morphology0.72462209
148MP0005025_abnormal_response_to0.68750315
149MP0001986_abnormal_taste_sensitivity0.68468167
150MP0002970_abnormal_white_adipose0.68448309
151MP0005000_abnormal_immune_tolerance0.68238131
152MP0000681_abnormal_thyroid_gland0.68068028
153MP0002932_abnormal_joint_morphology0.67439161
154MP0001661_extended_life_span0.66380710
155MP0008873_increased_physiological_sensi0.66282099
156MP0001186_pigmentation_phenotype0.65042750
157MP0004264_abnormal_extraembryonic_tissu0.65042732
158MP0005220_abnormal_exocrine_pancreas0.62415949
159MP0000477_abnormal_intestine_morphology0.61927051
160MP0002751_abnormal_autonomic_nervous0.61229121
161MP0001919_abnormal_reproductive_system0.61168419
162MP0005499_abnormal_olfactory_system0.58498723
163MP0005394_taste/olfaction_phenotype0.58498723
164MP0000678_abnormal_parathyroid_gland0.54928781
165MP0002420_abnormal_adaptive_immunity0.54032594
166MP0008260_abnormal_autophagy0.53156005
167MP0001819_abnormal_immune_cell0.52689984
168MP0001286_abnormal_eye_development0.52184536
169MP0003866_abnormal_defecation0.51374913
170MP0008995_early_reproductive_senescence0.50900320
171MP0003136_yellow_coat_color0.50370049
172MP0009703_decreased_birth_body0.49774400

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.13334252
2Abnormal number of erythroid precursors (HP:0012131)4.95280625
3Abnormality of cells of the erythroid lineage (HP:0012130)4.87517762
4Reticulocytopenia (HP:0001896)4.49487967
5Cerebral palsy (HP:0100021)4.07519598
6Hepatic necrosis (HP:0002605)4.03243512
7Progressive microcephaly (HP:0000253)4.00980636
8Breast hypoplasia (HP:0003187)3.65890429
9Aplastic anemia (HP:0001915)3.54364520
10Abnormal mitochondria in muscle tissue (HP:0008316)3.52310721
11Colon cancer (HP:0003003)3.49809474
12Ragged-red muscle fibers (HP:0003200)3.44855818
13Oral leukoplakia (HP:0002745)3.40807580
14Testicular atrophy (HP:0000029)3.37551134
15Cerebral hypomyelination (HP:0006808)3.37339014
16Acute necrotizing encephalopathy (HP:0006965)3.32156775
17Rough bone trabeculation (HP:0100670)3.31134293
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28429119
19Chromsome breakage (HP:0040012)3.28142583
20Dicarboxylic aciduria (HP:0003215)3.23036360
21Abnormality of dicarboxylic acid metabolism (HP:0010995)3.23036360
22Carpal bone hypoplasia (HP:0001498)3.21900967
23Degeneration of anterior horn cells (HP:0002398)3.21602909
24Abnormality of the anterior horn cell (HP:0006802)3.21602909
25Patellar aplasia (HP:0006443)3.13316986
26Increased muscle lipid content (HP:0009058)3.12555909
27Acute encephalopathy (HP:0006846)3.10101196
28Pallor (HP:0000980)3.09935861
29Abnormality of the preputium (HP:0100587)3.08093366
30Selective tooth agenesis (HP:0001592)3.07913591
31Type I transferrin isoform profile (HP:0003642)3.05607806
32Opisthotonus (HP:0002179)3.03778610
3311 pairs of ribs (HP:0000878)2.96737402
34Abnormality of the ileum (HP:0001549)2.95233284
35Macrocytic anemia (HP:0001972)2.95034506
36Aplasia/Hypoplasia of the patella (HP:0006498)2.93778760
37Increased intramyocellular lipid droplets (HP:0012240)2.93564713
38Delayed CNS myelination (HP:0002188)2.89675026
39Meckel diverticulum (HP:0002245)2.88227222
40Absent thumb (HP:0009777)2.88190391
41Type II lissencephaly (HP:0007260)2.86222912
42Lactic acidosis (HP:0003128)2.84899660
43Myelodysplasia (HP:0002863)2.83769131
44Progressive muscle weakness (HP:0003323)2.81424575
45J-shaped sella turcica (HP:0002680)2.78130982
46Elevated erythrocyte sedimentation rate (HP:0003565)2.77216304
47Multiple enchondromatosis (HP:0005701)2.76091311
48Mesangial abnormality (HP:0001966)2.74783315
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73679149
50Trismus (HP:0000211)2.71903954
51Emotional lability (HP:0000712)2.71672890
52Ependymoma (HP:0002888)2.70103863
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.69497072
54Bone marrow hypocellularity (HP:0005528)2.62445081
55Progressive macrocephaly (HP:0004481)2.61523944
56Premature graying of hair (HP:0002216)2.61377773
57Abnormality of chromosome stability (HP:0003220)2.58346516
58Thrombocytosis (HP:0001894)2.56007976
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.55798972
60Supernumerary spleens (HP:0009799)2.55148774
61Pancytopenia (HP:0001876)2.53497435
62Microretrognathia (HP:0000308)2.49009908
63Agnosia (HP:0010524)2.48816598
64Horseshoe kidney (HP:0000085)2.48351847
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.47885851
66Visual hallucinations (HP:0002367)2.44994707
67Increased serum lactate (HP:0002151)2.44438859
68Microvesicular hepatic steatosis (HP:0001414)2.43498670
69Retinal dysplasia (HP:0007973)2.38981516
70Medulloblastoma (HP:0002885)2.38687996
71Duplicated collecting system (HP:0000081)2.38243541
72Ketosis (HP:0001946)2.37731860
73Hypoplasia of the pons (HP:0012110)2.37622538
74Small intestinal stenosis (HP:0012848)2.34137691
75Duodenal stenosis (HP:0100867)2.34137691
76Absent radius (HP:0003974)2.32605706
77Cerebral edema (HP:0002181)2.32030790
78Abnormal trabecular bone morphology (HP:0100671)2.30880634
79Cellular immunodeficiency (HP:0005374)2.30486755
80Impulsivity (HP:0100710)2.30212547
81Muscle fiber atrophy (HP:0100295)2.30152356
82Asplenia (HP:0001746)2.27263461
83Type 2 muscle fiber atrophy (HP:0003554)2.26716668
84Abnormality of the prostate (HP:0008775)2.26087535
85Lipid accumulation in hepatocytes (HP:0006561)2.25778780
86Severe muscular hypotonia (HP:0006829)2.24975635
87Abnormal protein N-linked glycosylation (HP:0012347)2.24922899
88Abnormal protein glycosylation (HP:0012346)2.24922899
89Abnormal glycosylation (HP:0012345)2.24922899
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24922899
91Congenital stationary night blindness (HP:0007642)2.24241899
92Exercise intolerance (HP:0003546)2.24241633
93Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22603948
94Ketoacidosis (HP:0001993)2.22120311
95Abnormality of the labia minora (HP:0012880)2.22087814
96Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21756228
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21756228
98Aplasia involving forearm bones (HP:0009822)2.20074000
99Absent forearm bone (HP:0003953)2.20074000
100Abnormality of the pons (HP:0007361)2.19391337
101Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17030544
102Agammaglobulinemia (HP:0004432)2.15824533
103Sloping forehead (HP:0000340)2.13640971
104Acute lymphatic leukemia (HP:0006721)2.13307277
105Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12918698
106Abnormality of the renal collecting system (HP:0004742)2.11964312
107Tracheoesophageal fistula (HP:0002575)2.11677157
108Panhypogammaglobulinemia (HP:0003139)2.11506025
109Neoplasm of the pancreas (HP:0002894)2.11496061
110Secondary amenorrhea (HP:0000869)2.11448245
111Lethargy (HP:0001254)2.10711009
112Premature ovarian failure (HP:0008209)2.08983727
113Severe combined immunodeficiency (HP:0004430)2.08295259
114Aplasia/Hypoplasia of the spleen (HP:0010451)2.07215433
115Cleft eyelid (HP:0000625)2.05014734
116Abnormal biliary tract physiology (HP:0012439)2.04788316
117Bile duct proliferation (HP:0001408)2.04788316
118Methylmalonic aciduria (HP:0012120)2.03657601
119Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03243147
120Stridor (HP:0010307)2.02402586
121Abnormality of the duodenum (HP:0002246)2.02152546
122Hepatocellular necrosis (HP:0001404)2.01916217
123Increased cerebral lipofuscin (HP:0011813)2.01702356
124Reduced antithrombin III activity (HP:0001976)2.01690674
125Pancreatic cysts (HP:0001737)2.00102888
1263-Methylglutaconic aciduria (HP:0003535)1.99519054
127Triphalangeal thumb (HP:0001199)1.99315569
128Atrophy/Degeneration involving motor neurons (HP:0007373)1.99231159
129Abnormality of the heme biosynthetic pathway (HP:0010472)1.98569244
130Missing ribs (HP:0000921)1.97903993
131Tachypnea (HP:0002789)1.97755107
132Hyperglycinuria (HP:0003108)1.97014090
133Increased hepatocellular lipid droplets (HP:0006565)1.96508153
134Spastic paraparesis (HP:0002313)1.93322324
135Hyperglycinemia (HP:0002154)1.92901094
136Respiratory failure (HP:0002878)1.91664903
137Sparse eyelashes (HP:0000653)1.91597260
138Rhabdomyosarcoma (HP:0002859)1.90120225
139Prostate neoplasm (HP:0100787)1.89817441
140IgM deficiency (HP:0002850)1.89353372
141CNS hypomyelination (HP:0003429)1.88485495
142Ureteral duplication (HP:0000073)1.88063650
143Lymphoma (HP:0002665)1.87656906
144Dry hair (HP:0011359)1.87636177
145Facial cleft (HP:0002006)1.87425251
146Squamous cell carcinoma (HP:0002860)1.86436585
147Basal cell carcinoma (HP:0002671)1.85732027
148Flat capital femoral epiphysis (HP:0003370)1.85416767
149Hypoplasia of the radius (HP:0002984)1.84875775
150Increased CSF lactate (HP:0002490)1.84260532
151Megaloblastic anemia (HP:0001889)1.83847611
152Optic nerve coloboma (HP:0000588)1.83385757
153Abnormal hair laboratory examination (HP:0003328)1.83305018
154Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82694369
155Large for gestational age (HP:0001520)1.81312784
156Optic disc pallor (HP:0000543)1.80628427
157CNS demyelination (HP:0007305)1.80011494
158Mitochondrial inheritance (HP:0001427)1.79817094
159Dysautonomia (HP:0002459)1.79779090
160Renal Fanconi syndrome (HP:0001994)1.79560025
161Unsteady gait (HP:0002317)1.79176720
162Cystic liver disease (HP:0006706)1.79116387
163IgG deficiency (HP:0004315)1.78231251
164Pancreatic fibrosis (HP:0100732)1.76135723
165Abnormality of serine family amino acid metabolism (HP:0010894)1.75978305
166Abnormality of glycine metabolism (HP:0010895)1.75978305
167Hemiparesis (HP:0001269)1.75959451
168Myokymia (HP:0002411)1.75284728
169Nephronophthisis (HP:0000090)1.75272898
170Cerebellar dysplasia (HP:0007033)1.75067560
171Seborrheic dermatitis (HP:0001051)1.71325660
172Hyperammonemia (HP:0001987)1.70787250
173Alkalosis (HP:0001948)1.70407020
174Molar tooth sign on MRI (HP:0002419)1.67885383
175Abnormality of midbrain morphology (HP:0002418)1.67885383
176Failure to thrive in infancy (HP:0001531)1.66842698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.56047905
2BUB14.88426598
3WEE14.02275267
4EIF2AK13.46282101
5STK163.41498384
6TSSK63.30617152
7CDC72.84083594
8NME22.75005044
9SRPK12.51845699
10SMG12.48732861
11EIF2AK32.39653091
12PLK42.24150677
13ERN12.23040888
14IRAK32.01650730
15PASK1.96653296
16NEK11.96451905
17PLK11.94440826
18TTK1.93579137
19RPS6KB21.90724275
20PIM21.90649338
21NEK21.87282294
22VRK11.81634213
23CDK71.81194035
24MAP4K21.81193543
25BRSK21.80365394
26DYRK31.75890991
27TLK11.66806493
28EPHA21.66131765
29MKNK11.63484411
30ATR1.57615745
31TAOK31.57314029
32AURKB1.47514803
33ACVR1B1.46478527
34TRIB31.42390252
35TGFBR11.42244810
36SCYL21.40225793
37PLK31.38544909
38ZAK1.37760853
39TNK21.36950762
40MAP2K21.36582300
41MAPKAPK51.33835078
42MKNK21.33628694
43DAPK21.31480116
44NUAK11.27794375
45TESK21.27391200
46PAK41.20866222
47TBK11.20455738
48TXK1.19899107
49RPS6KA41.18243460
50CHEK21.16304655
51MAPK151.11441204
52PRKCI1.10937627
53PIM11.10744125
54BRSK11.10627400
55KIT1.10374380
56AURKA1.09874539
57NME11.09521064
58GRK61.06054196
59CCNB11.04170308
60CAMKK11.02728405
61AKT31.02486694
62CDK191.00954090
63ADRBK20.99077364
64LIMK10.98476331
65CDK80.98378287
66CHEK10.96250615
67PHKG10.93893057
68PHKG20.93893057
69SIK20.91662889
70MUSK0.91082368
71CSNK1A1L0.90594747
72BCKDK0.90072131
73MAPK110.89202675
74EIF2AK20.87214149
75GRK10.87184397
76ABL20.86777401
77MAP3K80.79909219
78WNK40.79872550
79PRKD30.79740524
80FLT30.79649981
81CAMKK20.77118886
82EEF2K0.76906944
83FES0.74777488
84KDR0.74228526
85* CDK20.73547200
86CSNK2A20.73114213
87CSNK1G20.72705722
88PINK10.72373959
89MAP4K10.72195889
90DAPK10.71559841
91DAPK30.70637728
92CSNK2A10.70361585
93ARAF0.69384249
94PKN10.69092399
95BRAF0.68689178
96MAP2K30.67724655
97ATM0.67021095
98SYK0.66517690
99IRAK40.66504715
100MAP3K100.65206750
101PAK10.64802451
102INSRR0.62706404
103CDK40.61922601
104RAF10.61325999
105PDK20.59830494
106BRD40.58458992
107STK38L0.58003919
108TAOK20.57758818
109DYRK20.56975550
110MAPK130.56586450
111HIPK20.56558634
112ZAP700.56330107
113MAP3K70.56081594
114STK40.55029732
115ITK0.55006507
116CSNK1G10.52390499
117IKBKE0.52308063
118CDK120.52086075
119MATK0.52040802
120STK100.51856419
121NTRK10.50068718
122PAK60.49912831
123CSNK1G30.48942169
124CDK10.48793611
125GRK50.47010748
126PNCK0.46978911
127RPS6KA50.46615688
128BTK0.46171160
129SIK10.45692777
130CAMK10.45134236
131TIE10.43833079
132RPS6KB10.41607893
133MARK30.41289480
134JAK30.40662877
135YES10.40441872
136NTRK30.39025593
137CSF1R0.38615918
138IKBKB0.38531239
139MAPK40.38164804
140MAP3K110.37397026
141PRKD20.36477870
142CAMK2G0.35908652
143MAPKAPK30.35422563
144TEC0.34963184
145MAPK120.34858373
146NTRK20.34682620
147MAP2K70.34458517
148ILK0.34091298
149LRRK20.33773758
150CDK90.33078255
151LMTK20.31938629
152AKT20.31120439
153RPS6KL10.29302871
154RPS6KC10.29302871
155RPS6KA60.29034633
156PDK30.27202382
157PDK40.27202382
158KSR10.26410934
159CHUK0.24681818
160ALK0.24303009
161CSNK1E0.23751664
162TESK10.22644933
163MAP2K60.21778213

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.69276136
2Mismatch repair_Homo sapiens_hsa034304.20772704
3Ribosome_Homo sapiens_hsa030104.04210457
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.69897602
5RNA polymerase_Homo sapiens_hsa030203.66899616
6Proteasome_Homo sapiens_hsa030503.61409343
7Spliceosome_Homo sapiens_hsa030403.29025441
8Base excision repair_Homo sapiens_hsa034103.28233213
9RNA transport_Homo sapiens_hsa030133.05481390
10Homologous recombination_Homo sapiens_hsa034402.91626495
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.77172969
12Nucleotide excision repair_Homo sapiens_hsa034202.73782778
13Pyrimidine metabolism_Homo sapiens_hsa002402.73574996
14One carbon pool by folate_Homo sapiens_hsa006702.38556171
15Fanconi anemia pathway_Homo sapiens_hsa034602.21705786
16Cell cycle_Homo sapiens_hsa041102.14609468
17RNA degradation_Homo sapiens_hsa030181.99201139
18Non-homologous end-joining_Homo sapiens_hsa034501.94607362
19Basal transcription factors_Homo sapiens_hsa030221.90245584
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80543864
21Protein export_Homo sapiens_hsa030601.77089826
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.71600455
23Purine metabolism_Homo sapiens_hsa002301.54626053
24Fatty acid elongation_Homo sapiens_hsa000621.54307133
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52735856
26Asthma_Homo sapiens_hsa053101.49973471
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.45500457
28mRNA surveillance pathway_Homo sapiens_hsa030151.43929319
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42842793
30Peroxisome_Homo sapiens_hsa041461.39166850
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35510695
32p53 signaling pathway_Homo sapiens_hsa041151.34156345
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28653836
34Linoleic acid metabolism_Homo sapiens_hsa005911.24551150
35Butanoate metabolism_Homo sapiens_hsa006501.18182859
36Folate biosynthesis_Homo sapiens_hsa007901.17997268
37Epstein-Barr virus infection_Homo sapiens_hsa051691.17294230
38Allograft rejection_Homo sapiens_hsa053301.08733688
39Autoimmune thyroid disease_Homo sapiens_hsa053201.07464499
40Nitrogen metabolism_Homo sapiens_hsa009101.07260203
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04608395
42Phototransduction_Homo sapiens_hsa047440.98037200
43Sulfur metabolism_Homo sapiens_hsa009200.97064138
44Fatty acid metabolism_Homo sapiens_hsa012120.96826898
45Sulfur relay system_Homo sapiens_hsa041220.96699138
46Tryptophan metabolism_Homo sapiens_hsa003800.95074678
47Parkinsons disease_Homo sapiens_hsa050120.94524795
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.94135426
49Type I diabetes mellitus_Homo sapiens_hsa049400.92102392
50Synaptic vesicle cycle_Homo sapiens_hsa047210.89197027
51Biosynthesis of amino acids_Homo sapiens_hsa012300.88627564
52Huntingtons disease_Homo sapiens_hsa050160.88185327
53Pyruvate metabolism_Homo sapiens_hsa006200.88139656
54beta-Alanine metabolism_Homo sapiens_hsa004100.87283058
55Fructose and mannose metabolism_Homo sapiens_hsa000510.86298859
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84694025
57N-Glycan biosynthesis_Homo sapiens_hsa005100.84104839
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82807526
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.80234910
60Oxidative phosphorylation_Homo sapiens_hsa001900.79423359
61Graft-versus-host disease_Homo sapiens_hsa053320.77475124
62Pentose phosphate pathway_Homo sapiens_hsa000300.76975596
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.76544888
64Selenocompound metabolism_Homo sapiens_hsa004500.75133498
65Vitamin B6 metabolism_Homo sapiens_hsa007500.73002016
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71804108
67Antigen processing and presentation_Homo sapiens_hsa046120.70444474
68Herpes simplex infection_Homo sapiens_hsa051680.70067364
69Lysine degradation_Homo sapiens_hsa003100.67906361
70Systemic lupus erythematosus_Homo sapiens_hsa053220.66510912
71Histidine metabolism_Homo sapiens_hsa003400.65797691
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65338908
73Viral carcinogenesis_Homo sapiens_hsa052030.64525967
74ABC transporters_Homo sapiens_hsa020100.63960046
75Ether lipid metabolism_Homo sapiens_hsa005650.63671963
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62122871
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61356620
78Oocyte meiosis_Homo sapiens_hsa041140.61207956
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60702258
80Fatty acid degradation_Homo sapiens_hsa000710.60117501
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59702749
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.59381493
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57769509
84Galactose metabolism_Homo sapiens_hsa000520.57259009
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56102331
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55651582
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55449199
88Chemical carcinogenesis_Homo sapiens_hsa052040.55314958
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54865441
90Legionellosis_Homo sapiens_hsa051340.52825270
91Thyroid cancer_Homo sapiens_hsa052160.51984182
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50684784
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50544839
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50341880
95Propanoate metabolism_Homo sapiens_hsa006400.50194694
96Tyrosine metabolism_Homo sapiens_hsa003500.50142572
97Glutathione metabolism_Homo sapiens_hsa004800.48879920
98Phenylalanine metabolism_Homo sapiens_hsa003600.47510225
99HTLV-I infection_Homo sapiens_hsa051660.47392745
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47143489
101Nicotine addiction_Homo sapiens_hsa050330.46267859
102Glycerolipid metabolism_Homo sapiens_hsa005610.45844507
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.43061912
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42338861
105Cardiac muscle contraction_Homo sapiens_hsa042600.41911861
106Carbon metabolism_Homo sapiens_hsa012000.41383609
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39822238
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38701790
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37743271
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36812555
111Metabolic pathways_Homo sapiens_hsa011000.36757421
112Primary immunodeficiency_Homo sapiens_hsa053400.36222940
113Apoptosis_Homo sapiens_hsa042100.35305382
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34809575
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31098471
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30965593
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.29773427
118Acute myeloid leukemia_Homo sapiens_hsa052210.28909142
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28754684
120Alzheimers disease_Homo sapiens_hsa050100.25992729
121Shigellosis_Homo sapiens_hsa051310.25552488
122Regulation of autophagy_Homo sapiens_hsa041400.24374217
123Measles_Homo sapiens_hsa051620.23940101
124Alcoholism_Homo sapiens_hsa050340.23781982
125Arachidonic acid metabolism_Homo sapiens_hsa005900.23383935
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22685653
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21994306
128HIF-1 signaling pathway_Homo sapiens_hsa040660.21368363
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20048103
130Small cell lung cancer_Homo sapiens_hsa052220.19304725
131Colorectal cancer_Homo sapiens_hsa052100.17861783
132MicroRNAs in cancer_Homo sapiens_hsa052060.17340869
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15411370
134Hepatitis B_Homo sapiens_hsa051610.14686089
135Renin-angiotensin system_Homo sapiens_hsa046140.14529860
136Notch signaling pathway_Homo sapiens_hsa043300.14089207
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14027754
138Other glycan degradation_Homo sapiens_hsa005110.13460564
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13315476
140Hematopoietic cell lineage_Homo sapiens_hsa046400.12222047
141Arginine and proline metabolism_Homo sapiens_hsa003300.10992200
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.09801901
143Influenza A_Homo sapiens_hsa051640.08972664
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.07960954
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05880083
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.05228265
147Bladder cancer_Homo sapiens_hsa052190.04577638

Most similar genes based on co-expression Upload to Enrichr

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