QTRT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine, and tyrosine. The encoded protein may play a role in the queuosine 5'-monophosphate salvage pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.15752209
2nuclear pore complex assembly (GO:0051292)4.05749969
3negative regulation of DNA-dependent DNA replication (GO:2000104)4.00403875
4nuclear pore organization (GO:0006999)3.93309388
5mitotic metaphase plate congression (GO:0007080)3.90904621
6ribosome assembly (GO:0042255)3.88391743
7DNA replication checkpoint (GO:0000076)3.86658477
8regulation of mitotic spindle checkpoint (GO:1903504)3.80646415
9regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.80646415
10regulation of nuclear cell cycle DNA replication (GO:0033262)3.80221095
11pseudouridine synthesis (GO:0001522)3.77309842
12regulation of centriole replication (GO:0046599)3.77271333
13chromatin remodeling at centromere (GO:0031055)3.74280502
14replication fork processing (GO:0031297)3.72373870
15somatic diversification of immune receptors via somatic mutation (GO:0002566)3.63074336
16somatic hypermutation of immunoglobulin genes (GO:0016446)3.63074336
17somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.61632610
18somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.61632610
19isotype switching (GO:0045190)3.61632610
20CENP-A containing nucleosome assembly (GO:0034080)3.61233185
21metaphase plate congression (GO:0051310)3.59600472
22DNA strand elongation involved in DNA replication (GO:0006271)3.51094844
23mitotic sister chromatid cohesion (GO:0007064)3.51079373
24protein localization to kinetochore (GO:0034501)3.48331597
25RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.45956380
26mitochondrial RNA metabolic process (GO:0000959)3.39791255
27regulation of DNA endoreduplication (GO:0032875)3.39215363
28recombinational repair (GO:0000725)3.36644362
29double-strand break repair via homologous recombination (GO:0000724)3.35645236
30nucleobase biosynthetic process (GO:0046112)3.33546639
31DNA strand elongation (GO:0022616)3.33461370
32DNA replication-dependent nucleosome organization (GO:0034723)3.32991013
33DNA replication-dependent nucleosome assembly (GO:0006335)3.32991013
34proteasome assembly (GO:0043248)3.30560189
35maturation of 5.8S rRNA (GO:0000460)3.26411209
36double-strand break repair via nonhomologous end joining (GO:0006303)3.24590177
37non-recombinational repair (GO:0000726)3.24590177
38histone exchange (GO:0043486)3.24362075
39regulation of centrosome cycle (GO:0046605)3.20843279
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19316700
41telomere maintenance via semi-conservative replication (GO:0032201)3.19057985
42mitotic sister chromatid segregation (GO:0000070)3.17612910
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.16723215
44somatic recombination of immunoglobulin gene segments (GO:0016447)3.16471349
45spindle checkpoint (GO:0031577)3.14816971
46somatic diversification of immunoglobulins (GO:0016445)3.13944349
47DNA catabolic process, exonucleolytic (GO:0000738)3.13481657
48sister chromatid segregation (GO:0000819)3.12551636
49attachment of spindle microtubules to kinetochore (GO:0008608)3.12253238
50pore complex assembly (GO:0046931)3.12130992
51transcription from mitochondrial promoter (GO:0006390)3.11501542
52mitotic nuclear envelope disassembly (GO:0007077)3.10940695
53response to X-ray (GO:0010165)3.07178170
54telomere maintenance via recombination (GO:0000722)3.06534063
55mitotic spindle checkpoint (GO:0071174)3.04777084
56regulation of centrosome duplication (GO:0010824)3.04706655
57DNA replication initiation (GO:0006270)3.04250922
58respiratory chain complex IV assembly (GO:0008535)3.04165498
59mitotic recombination (GO:0006312)3.03959985
60DNA deamination (GO:0045006)3.03844230
61protein localization to chromosome, centromeric region (GO:0071459)3.03833795
62negative regulation of chromosome segregation (GO:0051985)3.03172796
63purine nucleobase biosynthetic process (GO:0009113)3.02164230
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.01326260
65negative regulation of sister chromatid segregation (GO:0033046)3.01326260
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01326260
67negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01326260
68negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01326260
69rRNA modification (GO:0000154)3.01144497
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97709677
71histone mRNA metabolic process (GO:0008334)2.96472883
72regulation of helicase activity (GO:0051095)2.96001337
73regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95810811
74regulation of mitotic metaphase/anaphase transition (GO:0030071)2.95810811
75telomere maintenance via telomerase (GO:0007004)2.95297855
76postreplication repair (GO:0006301)2.95122248
77protein K6-linked ubiquitination (GO:0085020)2.95061262
78positive regulation of chromosome segregation (GO:0051984)2.92290796
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92106762
80IMP biosynthetic process (GO:0006188)2.88202460
81regulation of sister chromatid segregation (GO:0033045)2.87449470
82regulation of mitotic sister chromatid separation (GO:0010965)2.87449470
83regulation of mitotic sister chromatid segregation (GO:0033047)2.87449470
84ribosome biogenesis (GO:0042254)2.87210921
85synapsis (GO:0007129)2.86544891
86positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86052395
87positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86052395
88positive regulation of mitotic sister chromatid separation (GO:1901970)2.86052395
89nucleotide-excision repair, DNA gap filling (GO:0006297)2.85766953
90double-strand break repair (GO:0006302)2.85048025
91rRNA methylation (GO:0031167)2.84529744
92protein K11-linked deubiquitination (GO:0035871)2.84208778
93establishment of chromosome localization (GO:0051303)2.83831527
94regulation of chromosome segregation (GO:0051983)2.83729300
95transcription elongation from RNA polymerase I promoter (GO:0006362)2.81940244
96establishment of integrated proviral latency (GO:0075713)2.81110662
97DNA replication-independent nucleosome organization (GO:0034724)2.81069390
98DNA replication-independent nucleosome assembly (GO:0006336)2.81069390
99folic acid-containing compound biosynthetic process (GO:0009396)2.79273945
100kinetochore organization (GO:0051383)2.78884665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.16748064
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.24202651
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.89024996
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.34098704
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.16963165
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.16157270
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.08355847
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.00896785
9ELK1_19687146_ChIP-ChIP_HELA_Human2.81978048
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71647534
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.65551687
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49505827
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.43136905
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33197510
15VDR_23849224_ChIP-Seq_CD4+_Human2.30534876
16ZNF274_21170338_ChIP-Seq_K562_Hela2.27359499
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22484180
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20811516
19EWS_26573619_Chip-Seq_HEK293_Human2.19511756
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15232070
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14868968
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.13281409
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.11836428
24FOXP3_21729870_ChIP-Seq_TREG_Human2.10701852
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08761975
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96664002
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.92356640
28FUS_26573619_Chip-Seq_HEK293_Human1.89825624
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.88860991
30VDR_22108803_ChIP-Seq_LS180_Human1.88195036
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79218737
32MYC_18940864_ChIP-ChIP_HL60_Human1.78585835
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71479066
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64999276
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63950222
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57217960
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55135702
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53891355
39DCP1A_22483619_ChIP-Seq_HELA_Human1.51316947
40AR_21909140_ChIP-Seq_LNCAP_Human1.41966279
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41655304
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40587551
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37443610
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37390748
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.36561920
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36094997
47IGF1R_20145208_ChIP-Seq_DFB_Human1.35438996
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35217375
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34044670
50TTF2_22483619_ChIP-Seq_HELA_Human1.32845929
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30288311
52P300_19829295_ChIP-Seq_ESCs_Human1.28467644
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27079765
54GABP_19822575_ChIP-Seq_HepG2_Human1.27044283
55IRF1_19129219_ChIP-ChIP_H3396_Human1.22930940
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20636978
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20635852
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.17601754
59KDM5A_27292631_Chip-Seq_BREAST_Human1.17508858
60TAF15_26573619_Chip-Seq_HEK293_Human1.14992940
61ER_23166858_ChIP-Seq_MCF-7_Human1.13485640
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13377919
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09328926
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07815289
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07446694
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05662813
67NANOG_16153702_ChIP-ChIP_HESCs_Human0.99073685
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98966190
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98742774
70CBP_20019798_ChIP-Seq_JUKART_Human0.98742774
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97680468
72TP53_22573176_ChIP-Seq_HFKS_Human0.97088998
73EZH2_27294783_Chip-Seq_NPCs_Mouse0.95498505
74THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94092406
75PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92606241
76NFE2_27457419_Chip-Seq_LIVER_Mouse0.92337592
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91558870
78SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89449441
79SOX2_16153702_ChIP-ChIP_HESCs_Human0.88585967
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87711246
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86375868
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86279317
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84810012
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84135557
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83812849
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83749784
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83565721
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81897025
89NANOG_19829295_ChIP-Seq_ESCs_Human0.81779503
90SOX2_19829295_ChIP-Seq_ESCs_Human0.81779503
91XRN2_22483619_ChIP-Seq_HELA_Human0.80389418
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.80328593
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79407927
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79372584
95TCF4_22108803_ChIP-Seq_LS180_Human0.79267548
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79077832
97FOXA1_25329375_ChIP-Seq_VCAP_Human0.79077832
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77226841
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76862837
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.76282090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.13856476
2MP0010094_abnormal_chromosome_stability4.54809204
3MP0003693_abnormal_embryo_hatching4.19552943
4MP0008058_abnormal_DNA_repair4.13024910
5MP0008877_abnormal_DNA_methylation3.50078258
6MP0003111_abnormal_nucleus_morphology3.49068692
7MP0004957_abnormal_blastocyst_morpholog3.29736509
8MP0003077_abnormal_cell_cycle3.04388647
9MP0008007_abnormal_cellular_replicative2.74524393
10MP0006292_abnormal_olfactory_placode2.61036002
11MP0003718_maternal_effect2.58359436
12MP0009697_abnormal_copulation2.53181992
13MP0003786_premature_aging2.26257249
14MP0002102_abnormal_ear_morphology1.98514923
15MP0008932_abnormal_embryonic_tissue1.94707751
16MP0003890_abnormal_embryonic-extraembry1.94141343
17MP0000569_abnormal_digit_pigmentation1.93308690
18MP0003195_calcinosis1.82846263
19MP0000372_irregular_coat_pigmentation1.66715566
20MP0010307_abnormal_tumor_latency1.62305857
21MP0002160_abnormal_reproductive_system1.59310390
22MP0001293_anophthalmia1.59096118
23MP0002938_white_spotting1.58908980
24MP0005075_abnormal_melanosome_morpholog1.55752315
25MP0003806_abnormal_nucleotide_metabolis1.47473177
26MP0002396_abnormal_hematopoietic_system1.47077791
27MP0000427_abnormal_hair_cycle1.33822513
28MP0000383_abnormal_hair_follicle1.33443550
29MP0006072_abnormal_retinal_apoptosis1.32384251
30MP0006035_abnormal_mitochondrial_morpho1.32148741
31MP0003937_abnormal_limbs/digits/tail_de1.29829213
32MP0000350_abnormal_cell_proliferation1.27001384
33MP0001697_abnormal_embryo_size1.24876774
34MP0001929_abnormal_gametogenesis1.24310427
35MP0001730_embryonic_growth_arrest1.21608622
36MP0002254_reproductive_system_inflammat1.20972539
37MP0005380_embryogenesis_phenotype1.20166826
38MP0001672_abnormal_embryogenesis/_devel1.20166826
39MP0010352_gastrointestinal_tract_polyps1.20118013
40MP0005389_reproductive_system_phenotype1.19925654
41MP0003567_abnormal_fetal_cardiomyocyte1.18135280
42MP0002163_abnormal_gland_morphology1.17569524
43MP0005174_abnormal_tail_pigmentation1.16509127
44MP0002210_abnormal_sex_determination1.15595475
45MP0005395_other_phenotype1.09353942
46MP0010678_abnormal_skin_adnexa1.09025216
47MP0002084_abnormal_developmental_patter1.07002023
48MP0003941_abnormal_skin_development1.05697978
49MP0000647_abnormal_sebaceous_gland1.05403752
50MP0005253_abnormal_eye_physiology1.03961775
51MP0003787_abnormal_imprinting1.03151599
52MP0005551_abnormal_eye_electrophysiolog1.02339497
53MP0001145_abnormal_male_reproductive1.02295926
54MP0002088_abnormal_embryonic_growth/wei1.02220063
55MP0000653_abnormal_sex_gland1.01617985
56MP0003984_embryonic_growth_retardation1.00876295
57MP0003943_abnormal_hepatobiliary_system1.00326033
58MP0002085_abnormal_embryonic_tissue0.99554703
59MP0000313_abnormal_cell_death0.98004274
60MP0001119_abnormal_female_reproductive0.96291313
61MP0003950_abnormal_plasma_membrane0.95984200
62MP0002019_abnormal_tumor_incidence0.95650472
63MP0008872_abnormal_physiological_respon0.94227114
64MP0001919_abnormal_reproductive_system0.93499825
65MP0000358_abnormal_cell_content/0.91300464
66MP0001286_abnormal_eye_development0.91246618
67MP0008995_early_reproductive_senescence0.90918890
68MP0003121_genomic_imprinting0.87564300
69MP0002080_prenatal_lethality0.87233380
70MP0002009_preneoplasia0.86928995
71MP0005379_endocrine/exocrine_gland_phen0.84722968
72MP0003646_muscle_fatigue0.84513019
73MP0004197_abnormal_fetal_growth/weight/0.84248489
74MP0001324_abnormal_eye_pigmentation0.83765882
75MP0000631_abnormal_neuroendocrine_gland0.82983732
76MP0002095_abnormal_skin_pigmentation0.79447963
77MP0003186_abnormal_redox_activity0.77674812
78MP0001764_abnormal_homeostasis0.77420054
79MP0005410_abnormal_fertilization0.77413207
80MP0000015_abnormal_ear_pigmentation0.76483583
81MP0003698_abnormal_male_reproductive0.75765490
82MP0005084_abnormal_gallbladder_morpholo0.75140064
83MP0006036_abnormal_mitochondrial_physio0.74982619
84MP0004133_heterotaxia0.74199136
85MP0008875_abnormal_xenobiotic_pharmacok0.74004420
86MP0002006_tumorigenesis0.73901744
87MP0005408_hypopigmentation0.73700573
88MP0001188_hyperpigmentation0.73119615
89MP0002086_abnormal_extraembryonic_tissu0.71553417
90MP0001485_abnormal_pinna_reflex0.71105511
91MP0002751_abnormal_autonomic_nervous0.70838050
92MP0005391_vision/eye_phenotype0.70710661
93MP0002111_abnormal_tail_morphology0.70552140
94MP0002233_abnormal_nose_morphology0.69742985
95MP0004808_abnormal_hematopoietic_stem0.69044801
96MP0004043_abnormal_pH_regulation0.68415153
97MP0000371_diluted_coat_color0.67650723
98MP0003136_yellow_coat_color0.67362562
99MP0003699_abnormal_female_reproductive0.67203911
100MP0003119_abnormal_digestive_system0.64807156

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.05159282
2Chromsome breakage (HP:0040012)4.00337911
3Abnormality of chromosome stability (HP:0003220)3.84859395
4Meckel diverticulum (HP:0002245)3.46237855
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.45033535
6Abnormality of the ileum (HP:0001549)3.39445018
7Abnormality of the preputium (HP:0100587)3.38364579
8Birth length less than 3rd percentile (HP:0003561)3.36074032
9Pancreatic cysts (HP:0001737)3.04716944
10Abnormality of the labia minora (HP:0012880)2.87968951
11Colon cancer (HP:0003003)2.72348964
12Clubbing of toes (HP:0100760)2.66525846
13Sloping forehead (HP:0000340)2.62880364
14Pancreatic fibrosis (HP:0100732)2.61724185
15Abnormality of the pons (HP:0007361)2.56524428
16Small intestinal stenosis (HP:0012848)2.55980906
17Duodenal stenosis (HP:0100867)2.55980906
18Abnormality of midbrain morphology (HP:0002418)2.46186957
19Molar tooth sign on MRI (HP:0002419)2.46186957
20Volvulus (HP:0002580)2.44774817
21Abnormality of the duodenum (HP:0002246)2.36543622
22Hypoplasia of the pons (HP:0012110)2.34647824
23Nephroblastoma (Wilms tumor) (HP:0002667)2.33579311
24True hermaphroditism (HP:0010459)2.33163282
25Progressive inability to walk (HP:0002505)2.30748784
26Neoplasm of the adrenal cortex (HP:0100641)2.30274290
27Abnormality of the carotid arteries (HP:0005344)2.29634226
28Myelodysplasia (HP:0002863)2.27201813
29Embryonal renal neoplasm (HP:0011794)2.24467664
30Absent thumb (HP:0009777)2.16502890
31Pendular nystagmus (HP:0012043)2.16067191
32Glioma (HP:0009733)2.11340653
33Ectopic kidney (HP:0000086)2.10355350
34Rhabdomyosarcoma (HP:0002859)2.08010199
35Increased CSF lactate (HP:0002490)2.05406537
36Abnormality of alanine metabolism (HP:0010916)2.03076480
37Hyperalaninemia (HP:0003348)2.03076480
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03076480
39Nephronophthisis (HP:0000090)2.02790225
40Abnormality of the renal cortex (HP:0011035)2.02560684
41Abolished electroretinogram (ERG) (HP:0000550)1.96202730
42Abnormal lung lobation (HP:0002101)1.95351105
43Intestinal atresia (HP:0011100)1.95032959
44Type I transferrin isoform profile (HP:0003642)1.94870374
45Abnormality of DNA repair (HP:0003254)1.94065181
46Absent radius (HP:0003974)1.92599809
47Triphalangeal thumb (HP:0001199)1.91796962
48Pancreatic islet-cell hyperplasia (HP:0004510)1.90964122
49Increased serum lactate (HP:0002151)1.90409218
50Ependymoma (HP:0002888)1.90236031
51Patellar aplasia (HP:0006443)1.89462510
52Small hand (HP:0200055)1.88475093
53Abnormality of B cell number (HP:0010975)1.86876015
54Absent forearm bone (HP:0003953)1.86250833
55Aplasia involving forearm bones (HP:0009822)1.86250833
56Methylmalonic acidemia (HP:0002912)1.85985016
57Chronic hepatic failure (HP:0100626)1.85937114
58Fair hair (HP:0002286)1.85885405
59Sensory axonal neuropathy (HP:0003390)1.85491178
60Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84159103
61Acute necrotizing encephalopathy (HP:0006965)1.80966547
62Attenuation of retinal blood vessels (HP:0007843)1.80886504
63Cerebellar dysplasia (HP:0007033)1.80309749
64Dandy-Walker malformation (HP:0001305)1.80141088
65Abnormality of the renal medulla (HP:0100957)1.79671894
66Horseshoe kidney (HP:0000085)1.79297525
67Abnormal biliary tract physiology (HP:0012439)1.77946665
68Bile duct proliferation (HP:0001408)1.77946665
69Abnormality of methionine metabolism (HP:0010901)1.77639302
70Medulloblastoma (HP:0002885)1.77277808
71Acute encephalopathy (HP:0006846)1.76771697
72Premature ovarian failure (HP:0008209)1.75139215
73Short thumb (HP:0009778)1.74765915
74Oligodactyly (hands) (HP:0001180)1.73433070
75Medial flaring of the eyebrow (HP:0010747)1.73382720
76Type II lissencephaly (HP:0007260)1.73208941
77Renal cortical cysts (HP:0000803)1.73196320
78Abnormal protein glycosylation (HP:0012346)1.73181053
79Abnormal glycosylation (HP:0012345)1.73181053
80Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73181053
81Abnormal protein N-linked glycosylation (HP:0012347)1.73181053
82Aplasia/Hypoplasia of the patella (HP:0006498)1.72602127
83Duplicated collecting system (HP:0000081)1.72108452
84Thyroiditis (HP:0100646)1.70241523
85Carpal bone hypoplasia (HP:0001498)1.69777302
86Abnormality of the renal collecting system (HP:0004742)1.69479752
87Congenital stationary night blindness (HP:0007642)1.69185553
88Neoplasm of the adrenal gland (HP:0100631)1.68846544
89Astigmatism (HP:0000483)1.68547560
90Preaxial hand polydactyly (HP:0001177)1.67793099
91Aplasia/Hypoplasia of the tongue (HP:0010295)1.65725735
92B lymphocytopenia (HP:0010976)1.65451944
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.64868166
94Sclerocornea (HP:0000647)1.64619348
95Lipid accumulation in hepatocytes (HP:0006561)1.64063343
96Combined immunodeficiency (HP:0005387)1.63468139
973-Methylglutaconic aciduria (HP:0003535)1.62919661
98Abnormality of serum amino acid levels (HP:0003112)1.62770753
99Cleft eyelid (HP:0000625)1.62211986
100Severe combined immunodeficiency (HP:0004430)1.62182344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.54362268
2ZAK3.39897696
3MST43.34636215
4FRK3.32489201
5CDC73.06320521
6MKNK22.99575678
7NUAK12.92813191
8SRPK12.62416477
9EIF2AK32.56934090
10TTK2.50805894
11TSSK62.44019334
12MKNK12.39977754
13TRIM282.33682066
14BRSK22.31701846
15BMPR1B2.22433183
16PLK32.11540724
17TNIK2.02495165
18PLK41.98957857
19VRK21.93591293
20PBK1.88071069
21WEE11.79444288
22NEK11.69652156
23TAF11.55725351
24VRK11.55154782
25PLK11.49000245
26WNK31.43109631
27STK31.34684141
28STK161.34524111
29ACVR1B1.33895745
30STK391.32186819
31ATR1.31277837
32EIF2AK11.28881102
33MAP4K21.28453136
34CHEK21.24358400
35OXSR11.17678132
36LATS11.13358397
37STK38L1.10503332
38DYRK31.07096888
39ADRBK21.04874872
40WNK41.04759882
41RPS6KB21.04603659
42GRK11.00037155
43PASK0.99846784
44NLK0.97709814
45TAOK30.95944786
46RPS6KA40.90392132
47EIF2AK20.88982209
48ATM0.87390823
49AURKB0.87043335
50CHEK10.86159755
51BRD40.85638998
52TEC0.83773322
53TLK10.83651160
54PNCK0.81523734
55NEK20.80015002
56TGFBR10.76554464
57INSRR0.75999511
58NME10.72245905
59ERBB30.71415037
60BCR0.63898827
61PDK20.62879942
62STK100.58790577
63CSNK1G10.57681371
64PLK20.57095320
65FLT30.56462781
66BRSK10.56227074
67PRKCI0.54639522
68CDK30.53923097
69MELK0.53561301
70CDK70.51978602
71ERBB40.49141110
72STK40.49021126
73ALK0.48253496
74CDK10.41263924
75TXK0.39919497
76RPS6KA50.39907373
77FGFR10.39700745
78MAP3K40.39339764
79CSNK2A20.39247760
80CSNK2A10.39216443
81CSNK1E0.38741439
82STK240.37394088
83CDK20.37245228
84MAPKAPK50.36116515
85IRAK10.35167080
86AKT30.33458419
87CAMK1G0.32443447
88CAMK1D0.31636856
89TIE10.31484335
90CDK90.30259714
91PRKDC0.30004660
92MAP3K140.28962408
93IKBKB0.28521955
94AURKA0.26066956
95PIM10.25690969
96PRKCE0.25468638
97FER0.24476770
98CSNK1A1L0.24408023
99CDK80.23841946
100CSNK1G30.23666389

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.99771283
2Homologous recombination_Homo sapiens_hsa034403.63924639
3Non-homologous end-joining_Homo sapiens_hsa034503.53742235
4DNA replication_Homo sapiens_hsa030303.43002398
5Mismatch repair_Homo sapiens_hsa034303.41772071
6Proteasome_Homo sapiens_hsa030503.28343683
7RNA polymerase_Homo sapiens_hsa030203.00418197
8Fanconi anemia pathway_Homo sapiens_hsa034602.81927852
9Basal transcription factors_Homo sapiens_hsa030222.71748564
10One carbon pool by folate_Homo sapiens_hsa006702.63376545
11RNA transport_Homo sapiens_hsa030132.61946821
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44806148
13Selenocompound metabolism_Homo sapiens_hsa004502.42500964
14Nucleotide excision repair_Homo sapiens_hsa034202.40206991
15RNA degradation_Homo sapiens_hsa030182.33845108
16Spliceosome_Homo sapiens_hsa030402.23110702
17Protein export_Homo sapiens_hsa030602.22560325
18Base excision repair_Homo sapiens_hsa034102.15466589
19Cell cycle_Homo sapiens_hsa041102.09884321
20Pyrimidine metabolism_Homo sapiens_hsa002401.80941532
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63939697
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.56547637
23Purine metabolism_Homo sapiens_hsa002301.39206705
24Propanoate metabolism_Homo sapiens_hsa006401.37130095
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34780505
26mRNA surveillance pathway_Homo sapiens_hsa030151.31841659
27p53 signaling pathway_Homo sapiens_hsa041151.26787996
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25969058
29Ribosome_Homo sapiens_hsa030101.22665943
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19439551
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15690386
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15153783
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11416736
34Vitamin B6 metabolism_Homo sapiens_hsa007501.08362082
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06897012
36Phototransduction_Homo sapiens_hsa047441.02652850
37Oxidative phosphorylation_Homo sapiens_hsa001901.00315772
38Nitrogen metabolism_Homo sapiens_hsa009100.88691281
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88335605
40Huntingtons disease_Homo sapiens_hsa050160.82130078
41Parkinsons disease_Homo sapiens_hsa050120.81550478
42Lysine degradation_Homo sapiens_hsa003100.76436433
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73603856
44Tryptophan metabolism_Homo sapiens_hsa003800.72906692
45Steroid biosynthesis_Homo sapiens_hsa001000.71746267
46Butanoate metabolism_Homo sapiens_hsa006500.71045058
47Primary immunodeficiency_Homo sapiens_hsa053400.70868223
48Sulfur metabolism_Homo sapiens_hsa009200.69328928
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69248590
50Oocyte meiosis_Homo sapiens_hsa041140.67850355
51Ether lipid metabolism_Homo sapiens_hsa005650.61486378
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.58313900
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57302976
54Epstein-Barr virus infection_Homo sapiens_hsa051690.57101350
55Caffeine metabolism_Homo sapiens_hsa002320.56488715
56Linoleic acid metabolism_Homo sapiens_hsa005910.55231111
57Pyruvate metabolism_Homo sapiens_hsa006200.54941658
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54891234
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53841940
60TGF-beta signaling pathway_Homo sapiens_hsa043500.53609268
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51666878
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51605239
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51602820
64Metabolic pathways_Homo sapiens_hsa011000.49579379
65Systemic lupus erythematosus_Homo sapiens_hsa053220.48980452
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48967409
67Herpes simplex infection_Homo sapiens_hsa051680.48435072
68Regulation of autophagy_Homo sapiens_hsa041400.47187934
69Glutathione metabolism_Homo sapiens_hsa004800.43416298
70Peroxisome_Homo sapiens_hsa041460.40161820
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40084523
72beta-Alanine metabolism_Homo sapiens_hsa004100.39159146
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.38438425
74Vitamin digestion and absorption_Homo sapiens_hsa049770.35872326
75Asthma_Homo sapiens_hsa053100.35442740
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34145262
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33873353
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33782712
79Retinol metabolism_Homo sapiens_hsa008300.32130319
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30252251
81Olfactory transduction_Homo sapiens_hsa047400.30181534
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.29371642
83Antigen processing and presentation_Homo sapiens_hsa046120.26740556
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.25728777
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25648058
86Alzheimers disease_Homo sapiens_hsa050100.25453312
87Legionellosis_Homo sapiens_hsa051340.23825826
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.23541876
89Circadian rhythm_Homo sapiens_hsa047100.22913748
90N-Glycan biosynthesis_Homo sapiens_hsa005100.20753659
91Type I diabetes mellitus_Homo sapiens_hsa049400.20682438
92Measles_Homo sapiens_hsa051620.20289566
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.18932842
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17785804
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17122713
96Viral carcinogenesis_Homo sapiens_hsa052030.16631087
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16550369
98Folate biosynthesis_Homo sapiens_hsa007900.16037282
99Hippo signaling pathway_Homo sapiens_hsa043900.15042421
100Chemical carcinogenesis_Homo sapiens_hsa052040.14709095

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