R3HCC1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)7.67946183
2tolerance induction (GO:0002507)5.39784136
3DNA replication checkpoint (GO:0000076)5.11286852
4DNA catabolic process, exonucleolytic (GO:0000738)4.51127937
5mitochondrial DNA replication (GO:0006264)4.48353111
6regulation of interleukin-12 biosynthetic process (GO:0045075)4.45998955
7negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.23716785
8positive regulation of gamma-delta T cell activation (GO:0046645)4.17746216
9piRNA metabolic process (GO:0034587)3.94934801
10somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.85799818
11isotype switching (GO:0045190)3.85799818
12somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.85799818
13protein K11-linked deubiquitination (GO:0035871)3.84486024
14positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.82000613
15positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.69358710
16positive regulation of T cell differentiation in thymus (GO:0033089)3.67737564
17interferon-gamma production (GO:0032609)3.64908331
18antigen processing and presentation of endogenous antigen (GO:0019883)3.64820486
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.64492014
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.64492014
21replication fork processing (GO:0031297)3.62809980
22regulation of nuclear cell cycle DNA replication (GO:0033262)3.62416611
23regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.61766356
24regulation of DNA endoreduplication (GO:0032875)3.61699045
25immunoglobulin mediated immune response (GO:0016064)3.53623844
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.53189196
27positive regulation of B cell differentiation (GO:0045579)3.52015164
28regulation of interferon-beta biosynthetic process (GO:0045357)3.51265484
29regulation of B cell receptor signaling pathway (GO:0050855)3.49266936
30organelle membrane fusion (GO:0090174)3.42375441
31regulation of meiosis I (GO:0060631)3.41188018
32defense response to protozoan (GO:0042832)3.39653040
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.39422709
34negative regulation of cell killing (GO:0031342)3.39422709
35positive regulation of defense response to virus by host (GO:0002230)3.36737047
36telomere maintenance via semi-conservative replication (GO:0032201)3.34944661
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.31372309
38regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.29374819
39mitochondrial DNA metabolic process (GO:0032042)3.28191365
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.27761516
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27761516
42negative regulation of T-helper cell differentiation (GO:0045623)3.25236943
43negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.25236943
44negative regulation of interleukin-17 production (GO:0032700)3.25196785
45regulation of response to interferon-gamma (GO:0060330)3.24894030
46positive regulation of natural killer cell differentiation (GO:0032825)3.20498520
47adenosine metabolic process (GO:0046085)3.20484585
48resolution of meiotic recombination intermediates (GO:0000712)3.14042698
49response to protozoan (GO:0001562)3.13578728
50telomere maintenance via recombination (GO:0000722)3.12499901
51regulation of MHC class II biosynthetic process (GO:0045346)3.11508044
52dendritic cell chemotaxis (GO:0002407)3.11103866
53regulation of memory T cell differentiation (GO:0043380)3.10067355
54positive regulation of interferon-alpha production (GO:0032727)3.09789297
55positive regulation of uterine smooth muscle contraction (GO:0070474)3.09589257
56alternative mRNA splicing, via spliceosome (GO:0000380)3.09383745
57DNA methylation involved in gamete generation (GO:0043046)3.08332053
58mitotic sister chromatid cohesion (GO:0007064)3.06778362
59definitive hemopoiesis (GO:0060216)3.03322227
60B cell mediated immunity (GO:0019724)3.03181571
61intra-S DNA damage checkpoint (GO:0031573)3.02207576
62regulation of mitotic spindle checkpoint (GO:1903504)3.01540763
63regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01540763
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01358596
65somatic recombination of immunoglobulin gene segments (GO:0016447)2.99682779
66DNA strand elongation involved in DNA replication (GO:0006271)2.98889388
67regulation of interleukin-8 biosynthetic process (GO:0045414)2.97803744
68RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.97411703
69fucose catabolic process (GO:0019317)2.95107772
70L-fucose metabolic process (GO:0042354)2.95107772
71L-fucose catabolic process (GO:0042355)2.95107772
72cytidine deamination (GO:0009972)2.94005672
73cytidine metabolic process (GO:0046087)2.94005672
74cytidine catabolic process (GO:0006216)2.94005672
75regulation of T cell receptor signaling pathway (GO:0050856)2.92810030
76regulation of interferon-alpha production (GO:0032647)2.92663964
77chromatin remodeling at centromere (GO:0031055)2.91509507
78DNA-dependent DNA replication (GO:0006261)2.90850455
79fucosylation (GO:0036065)2.90194410
80regulation of gamma-delta T cell differentiation (GO:0045586)2.89096809
81negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88913772
82somatic diversification of immunoglobulins (GO:0016445)2.88088295
83synapsis (GO:0007129)2.87001926
84CENP-A containing nucleosome assembly (GO:0034080)2.86503559
85positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.85806193
86negative regulation of phagocytosis (GO:0050765)2.85136061
87regulation of centriole replication (GO:0046599)2.84250856
88megakaryocyte development (GO:0035855)2.83499694
89regulation of B cell differentiation (GO:0045577)2.81300548
90regulation of isotype switching to IgG isotypes (GO:0048302)2.80743593
91postreplication repair (GO:0006301)2.80387377
92positive regulation of isotype switching (GO:0045830)2.79589233
93DNA deamination (GO:0045006)2.79208358
94dendritic cell migration (GO:0036336)2.79113598
95DNA strand elongation (GO:0022616)2.78816663
96cell migration involved in gastrulation (GO:0042074)2.78750391
97regulation of RNA export from nucleus (GO:0046831)2.78697955
98regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.78686094
99protein K6-linked ubiquitination (GO:0085020)2.77466044
100neutrophil activation involved in immune response (GO:0002283)2.76222622
101negative regulation of B cell apoptotic process (GO:0002903)2.76142598
102cerebral cortex radially oriented cell migration (GO:0021799)2.73890581
103NIK/NF-kappaB signaling (GO:0038061)2.73553350
104positive regulation of interleukin-12 production (GO:0032735)2.73490534
105positive regulation of receptor biosynthetic process (GO:0010870)2.72860951
106germinal center formation (GO:0002467)2.72431106
107translesion synthesis (GO:0019985)2.72366468
108positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72248178
109negative T cell selection (GO:0043383)2.69807734
110positive regulation of interferon-beta production (GO:0032728)2.68280698
111regulation of gamma-delta T cell activation (GO:0046643)2.68082241
112response to UV-C (GO:0010225)2.67876981
113pyrimidine ribonucleoside catabolic process (GO:0046133)2.67254565
114mitotic recombination (GO:0006312)2.67149648
115regulation of alpha-beta T cell proliferation (GO:0046640)2.66263796
116pinocytosis (GO:0006907)2.65085839
117cytoplasmic mRNA processing body assembly (GO:0033962)2.64487723
118response to interleukin-15 (GO:0070672)2.63731959
119myeloid dendritic cell activation (GO:0001773)2.63085214
120cellular response to interferon-beta (GO:0035458)2.61871748
121B cell activation involved in immune response (GO:0002312)2.61253261
122negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61250660
123maturation of 5.8S rRNA (GO:0000460)2.60894197
124regulation of regulatory T cell differentiation (GO:0045589)2.59491717
125negative thymic T cell selection (GO:0045060)2.58227199
126recombinational repair (GO:0000725)2.57080911
127negative regulation of DNA-dependent DNA replication (GO:2000104)2.57011818
128negative regulation of immunoglobulin mediated immune response (GO:0002890)2.56893207
129negative regulation of B cell mediated immunity (GO:0002713)2.56893207
130regulation of isotype switching (GO:0045191)2.56139027
131regulation of DNA recombination (GO:0000018)2.55637791
132regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.52355621
133double-strand break repair via homologous recombination (GO:0000724)2.51790135
134positive regulation of alpha-beta T cell proliferation (GO:0046641)2.51485740
135embryonic hemopoiesis (GO:0035162)2.51294692
136positive regulation of interleukin-1 beta secretion (GO:0050718)2.50850124
137T cell homeostasis (GO:0043029)2.48739714
138regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.48268492
139positive regulation of B cell activation (GO:0050871)2.47093411
140somatic cell DNA recombination (GO:0016444)2.46777651
141somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.46777651
142N-acetylglucosamine metabolic process (GO:0006044)2.46239672
143microtubule depolymerization (GO:0007019)2.44452867
144somatic diversification of immune receptors (GO:0002200)2.42812617
145DNA topological change (GO:0006265)2.42598225
146regulation of interleukin-17 production (GO:0032660)2.41444576
147lysosome localization (GO:0032418)2.41279675
148telomere maintenance via telomere lengthening (GO:0010833)2.41130023
149regulation of interleukin-1 beta secretion (GO:0050706)2.40797095
150negative regulation of mRNA processing (GO:0050686)2.40556940
151maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.40177351
152regulation of T-helper 1 cell differentiation (GO:0045625)2.40078093
153regulation of T cell tolerance induction (GO:0002664)2.39005638
154positive regulation of DNA recombination (GO:0045911)2.38235182
155T-helper 1 type immune response (GO:0042088)2.38193842
156fatty acid elongation (GO:0030497)2.37850859
157positive regulation of chemokine biosynthetic process (GO:0045080)2.37579171
158negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.37350433
159positive regulation of cell killing (GO:0031343)2.36311501
160type I interferon signaling pathway (GO:0060337)2.35825793
161cellular response to type I interferon (GO:0071357)2.35825793
162meiotic chromosome segregation (GO:0045132)2.35612748
163regulation of necroptotic process (GO:0060544)2.35444817
164positive regulation of toll-like receptor signaling pathway (GO:0034123)2.34694282
165negative regulation of lipid storage (GO:0010888)2.34633229
166regulation of natural killer cell differentiation (GO:0032823)2.34537107
167monoubiquitinated protein deubiquitination (GO:0035520)2.34375418
168B cell receptor signaling pathway (GO:0050853)2.34165906
169response to type I interferon (GO:0034340)2.33459485
170positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.33088706
171neutrophil activation (GO:0042119)2.32889345
172negative regulation of B cell proliferation (GO:0030889)2.32868210
173positive regulation of B cell proliferation (GO:0030890)2.32617629
174hepatocyte apoptotic process (GO:0097284)2.32410713
175positive thymic T cell selection (GO:0045059)2.32157950
176cellular response to interleukin-15 (GO:0071350)2.31366825
177positive regulation of macrophage differentiation (GO:0045651)2.30371518
178regulation of B cell apoptotic process (GO:0002902)2.30253673
179regulation of nucleobase-containing compound transport (GO:0032239)2.27484225
180regulation of B cell proliferation (GO:0030888)2.27468165
181interferon-gamma-mediated signaling pathway (GO:0060333)2.25954048
182regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.25243966
183T cell differentiation involved in immune response (GO:0002292)2.24933955
184alpha-beta T cell activation involved in immune response (GO:0002287)2.24933955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.15652596
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.56337632
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.09214698
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.55014606
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.43479887
6VDR_22108803_ChIP-Seq_LS180_Human2.87861785
7SCL_19346495_ChIP-Seq_HPC-7_Human2.85816073
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.84728018
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.81581443
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.80803346
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.71200983
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.67563609
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.62560008
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.60860234
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.55318393
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.48598991
17ZNF274_21170338_ChIP-Seq_K562_Hela2.45201143
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.44557621
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.43630123
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37708403
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.36734685
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.26645808
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23308366
24RUNX_20019798_ChIP-Seq_JUKART_Human2.16096994
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14113048
26MYB_26560356_Chip-Seq_TH2_Human2.12189028
27GATA1_22025678_ChIP-Seq_K562_Human2.11367575
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10907810
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08714023
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06590566
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04467364
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00127068
33IRF1_19129219_ChIP-ChIP_H3396_Human1.95188714
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93091300
35SPI1_23547873_ChIP-Seq_NB4_Human1.91362237
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87859476
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87630775
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87227520
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82160614
40IGF1R_20145208_ChIP-Seq_DFB_Human1.78679095
41MYB_26560356_Chip-Seq_TH1_Human1.75112297
42EWS_26573619_Chip-Seq_HEK293_Human1.74936959
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74381426
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.73006751
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71062874
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69862588
47TAF15_26573619_Chip-Seq_HEK293_Human1.67903694
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66412956
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62780488
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61588035
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60892969
52MAF_26560356_Chip-Seq_TH1_Human1.56788700
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.55872108
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55334667
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.53221503
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52524357
57VDR_23849224_ChIP-Seq_CD4+_Human1.52270848
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51984961
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50617260
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.49921391
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48082426
62ELK1_19687146_ChIP-ChIP_HELA_Human1.46024711
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45918535
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45379000
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44749101
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.44456120
67FUS_26573619_Chip-Seq_HEK293_Human1.38486688
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38279976
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.37328899
70P300_19829295_ChIP-Seq_ESCs_Human1.36763966
71FOXP3_21729870_ChIP-Seq_TREG_Human1.35682100
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35453420
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35405033
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33978153
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.33470771
76* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31813018
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.30426123
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.29699681
79MYC_22102868_ChIP-Seq_BL_Human1.29579167
80CBP_20019798_ChIP-Seq_JUKART_Human1.28440713
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28440713
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28056974
83MYC_18940864_ChIP-ChIP_HL60_Human1.27574560
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26970663
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26150136
86PU_27001747_Chip-Seq_BMDM_Mouse1.25972478
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25093108
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.23570668
89GATA3_27048872_Chip-Seq_THYMUS_Human1.23248899
90ER_23166858_ChIP-Seq_MCF-7_Human1.23195420
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21854203
92VDR_21846776_ChIP-Seq_THP-1_Human1.20448483
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20401645
94VDR_24763502_ChIP-Seq_THP-1_Human1.20193102
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18140479
96ETS1_20019798_ChIP-Seq_JURKAT_Human1.18013092
97TP53_22573176_ChIP-Seq_HFKS_Human1.17473378
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17044315
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14313628
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14245133
101TFEB_21752829_ChIP-Seq_HELA_Human1.14192202
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13418228
103SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13211612
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11691143
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.10990713
106GABP_19822575_ChIP-Seq_HepG2_Human1.08941943
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08456888
108FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07702326
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.07262346
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06254424
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05705004
112GATA3_26560356_Chip-Seq_TH2_Human1.05621624
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05189725
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04905813
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03671961
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03331465
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.02884436
118FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02884436
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02261004
120SALL4_22934838_ChIP-ChIP_CD34+_Human1.02155228
121MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01829569
122BCAT_22108803_ChIP-Seq_LS180_Human1.01541772
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01096633
124KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00997828
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99769383
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99232834
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99079082
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98770473
129CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98303005
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98184667
131MYC_18555785_ChIP-Seq_MESCs_Mouse0.97655536
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97475084
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97335533
134JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97148658
135MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96756630
136GATA3_26560356_Chip-Seq_TH1_Human0.96647072
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96438350
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96108238
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.95971391
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95857958
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95838300
142SPI1_23127762_ChIP-Seq_K562_Human0.95551587
143OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95214154
144AR_21909140_ChIP-Seq_LNCAP_Human0.94866270
145CDX2_22108803_ChIP-Seq_LS180_Human0.94728023
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94329512
147CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93687803
148P300_18555785_Chip-Seq_ESCs_Mouse0.93283897
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93082377
150CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92998225
151CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92441447
152SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91376916
153SMAD3_21741376_ChIP-Seq_EPCs_Human0.90719581
154STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90676499
155CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90055041
156GATA2_21666600_ChIP-Seq_HMVEC_Human0.90020542
157SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89734614
158E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89725575
159PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89481802
160RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89304524
161SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89158578
162HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87551027
163KDM5A_27292631_Chip-Seq_BREAST_Human0.87309560
164UTX_26944678_Chip-Seq_JUKART_Human0.86945321
165DCP1A_22483619_ChIP-Seq_HELA_Human0.86681536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.89873384
2MP0006292_abnormal_olfactory_placode3.15323092
3MP0002396_abnormal_hematopoietic_system2.85502670
4MP0005671_abnormal_response_to2.76501505
5MP0000685_abnormal_immune_system2.49445552
6MP0001873_stomach_inflammation2.46438072
7MP0001800_abnormal_humoral_immune2.40628720
8MP0003724_increased_susceptibility_to2.38860503
9MP0002254_reproductive_system_inflammat2.37908409
10MP0009333_abnormal_splenocyte_physiolog2.28514110
11MP0003763_abnormal_thymus_physiology2.26599974
12MP0000569_abnormal_digit_pigmentation2.25725792
13MP0009785_altered_susceptibility_to2.18713643
14MP0002148_abnormal_hypersensitivity_rea2.18345350
15MP0002166_altered_tumor_susceptibility2.18316817
16MP0010094_abnormal_chromosome_stability2.17511585
17MP0005387_immune_system_phenotype2.16354154
18MP0001790_abnormal_immune_system2.16354154
19MP0005000_abnormal_immune_tolerance2.15246672
20MP0002452_abnormal_antigen_presenting2.12726592
21MP0002398_abnormal_bone_marrow2.08695339
22MP0003890_abnormal_embryonic-extraembry2.05496184
23MP0002723_abnormal_immune_serum2.04295314
24MP0000371_diluted_coat_color2.02097185
25MP0005025_abnormal_response_to2.01888473
26MP0004147_increased_porphyrin_level1.99929391
27MP0003191_abnormal_cellular_cholesterol1.99038542
28MP0003436_decreased_susceptibility_to1.96460464
29MP0002420_abnormal_adaptive_immunity1.95250041
30MP0002405_respiratory_system_inflammati1.94254455
31MP0001853_heart_inflammation1.93816107
32MP0001819_abnormal_immune_cell1.91822419
33MP0002419_abnormal_innate_immunity1.84912168
34MP0002139_abnormal_hepatobiliary_system1.84363551
35MP0000689_abnormal_spleen_morphology1.83225788
36MP0000716_abnormal_immune_system1.77786365
37MP0010307_abnormal_tumor_latency1.72216210
38MP0000465_gastrointestinal_hemorrhage1.71735210
39MP0008789_abnormal_olfactory_epithelium1.70621239
40MP0002933_joint_inflammation1.66795390
41MP0004808_abnormal_hematopoietic_stem1.63886578
42MP0002722_abnormal_immune_system1.62169180
43MP0002429_abnormal_blood_cell1.60052594
44MP0002006_tumorigenesis1.59220407
45MP0001324_abnormal_eye_pigmentation1.56591920
46MP0009764_decreased_sensitivity_to1.55350462
47MP0000703_abnormal_thymus_morphology1.54162091
48MP0005075_abnormal_melanosome_morpholog1.53104588
49MP0008058_abnormal_DNA_repair1.50422391
50MP0008007_abnormal_cellular_replicative1.48903039
51MP0006082_CNS_inflammation1.47990388
52MP0001919_abnormal_reproductive_system1.47650401
53MP0003448_altered_tumor_morphology1.46542789
54MP0003195_calcinosis1.46480909
55MP0006054_spinal_hemorrhage1.42313560
56MP0003300_gastrointestinal_ulcer1.39849024
57MP0003077_abnormal_cell_cycle1.39527775
58MP0000015_abnormal_ear_pigmentation1.38673444
59MP0001845_abnormal_inflammatory_respons1.38251998
60MP0002653_abnormal_ependyma_morphology1.37745708
61MP0002132_abnormal_respiratory_system1.35074535
62MP0003656_abnormal_erythrocyte_physiolo1.31575077
63MP0005464_abnormal_platelet_physiology1.30276011
64MP0005174_abnormal_tail_pigmentation1.30270019
65MP0008057_abnormal_DNA_replication1.30043518
66MP0004947_skin_inflammation1.28798763
67MP0000566_synostosis1.27986009
68MP0001533_abnormal_skeleton_physiology1.26177660
69MP0008469_abnormal_protein_level1.25857576
70MP0001293_anophthalmia1.23281520
71MP0003011_delayed_dark_adaptation1.21107671
72MP0000427_abnormal_hair_cycle1.20300318
73MP0010155_abnormal_intestine_physiology1.20109028
74MP0006035_abnormal_mitochondrial_morpho1.18378211
75MP0002095_abnormal_skin_pigmentation1.15562335
76MP0003221_abnormal_cardiomyocyte_apopto1.14925025
77MP0010678_abnormal_skin_adnexa1.12447930
78MP0002009_preneoplasia1.11947488
79MP0005499_abnormal_olfactory_system1.11368670
80MP0005394_taste/olfaction_phenotype1.11368670
81MP0003806_abnormal_nucleotide_metabolis1.11348428
82MP0003943_abnormal_hepatobiliary_system1.10658168
83MP0010234_abnormal_vibrissa_follicle1.08899949
84MP0009697_abnormal_copulation1.08298983
85MP0001119_abnormal_female_reproductive1.08090027
86MP0005408_hypopigmentation1.07833307
87MP0001929_abnormal_gametogenesis1.06010675
88MP0010352_gastrointestinal_tract_polyps1.04919025
89MP0003693_abnormal_embryo_hatching1.01252907
90MP0000358_abnormal_cell_content/0.99152264
91MP0002210_abnormal_sex_determination0.97610781
92MP0000858_altered_metastatic_potential0.95599336
93MP0001545_abnormal_hematopoietic_system0.93201048
94MP0005397_hematopoietic_system_phenotyp0.93201048
95MP0000383_abnormal_hair_follicle0.91597022
96MP0001851_eye_inflammation0.90895462
97MP0002075_abnormal_coat/hair_pigmentati0.90065121
98MP0003111_abnormal_nucleus_morphology0.89916140
99MP0008877_abnormal_DNA_methylation0.89178176
100MP0008932_abnormal_embryonic_tissue0.88632671
101MP0002102_abnormal_ear_morphology0.87615454
102MP0005551_abnormal_eye_electrophysiolog0.83522308
103MP0003718_maternal_effect0.83414723
104MP0002019_abnormal_tumor_incidence0.83364519
105MP0001764_abnormal_homeostasis0.82792316
106MP0003950_abnormal_plasma_membrane0.81792012
107MP0005389_reproductive_system_phenotype0.81601768
108MP0002938_white_spotting0.81567293
109MP0000490_abnormal_crypts_of0.80511314
110MP0002234_abnormal_pharynx_morphology0.79604720
111MP0008260_abnormal_autophagy0.79465154
112MP0009763_increased_sensitivity_to0.79274228
113MP0002163_abnormal_gland_morphology0.78790875
114MP0005647_abnormal_sex_gland0.78783852
115MP0005310_abnormal_salivary_gland0.77800697
116MP0002060_abnormal_skin_morphology0.77510377
117MP0005379_endocrine/exocrine_gland_phen0.77297647
118MP0001243_abnormal_dermal_layer0.77030576
119MP0005253_abnormal_eye_physiology0.76517859
120MP0001145_abnormal_male_reproductive0.75897220
121MP0004957_abnormal_blastocyst_morpholog0.74462331
122MP0005390_skeleton_phenotype0.74424396
123MP0000372_irregular_coat_pigmentation0.74073729
124MP0004381_abnormal_hair_follicle0.73884619
125MP0002751_abnormal_autonomic_nervous0.73328927
126MP0000653_abnormal_sex_gland0.73222275
127MP0003186_abnormal_redox_activity0.73057421
128MP0001348_abnormal_lacrimal_gland0.71920814
129MP0002138_abnormal_hepatobiliary_system0.71316455
130MP0002090_abnormal_vision0.70064109
131MP0005023_abnormal_wound_healing0.69574202
132MP0004484_altered_response_of0.69388786
133MP0003183_abnormal_peptide_metabolism0.69143668
134MP0005391_vision/eye_phenotype0.68819018
135MP0009765_abnormal_xenobiotic_induced0.66548123
136MP0003045_fibrosis0.66272425
137MP0000598_abnormal_liver_morphology0.65641303
138MP0000313_abnormal_cell_death0.64293120
139MP0005076_abnormal_cell_differentiation0.63369370
140MP0000350_abnormal_cell_proliferation0.62806357
141MP0000609_abnormal_liver_physiology0.62643771
142MP0003566_abnormal_cell_adhesion0.60083502
143MP0009840_abnormal_foam_cell0.60023455
144MP0003941_abnormal_skin_development0.59477219
145MP0003172_abnormal_lysosome_physiology0.58268381
146MP0003866_abnormal_defecation0.58131778
147MP0001881_abnormal_mammary_gland0.57826561

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.07692254
2Albinism (HP:0001022)3.82570238
3Myositis (HP:0100614)3.79786778
4Eczematoid dermatitis (HP:0000976)3.47911631
5Oligodactyly (hands) (HP:0001180)3.45918012
6Thrombocytosis (HP:0001894)3.34962235
7Abnormality of alanine metabolism (HP:0010916)3.31268201
8Hyperalaninemia (HP:0003348)3.31268201
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.31268201
10Recurrent abscess formation (HP:0002722)3.29867899
11Optic neuritis (HP:0100653)3.26023787
12Retrobulbar optic neuritis (HP:0100654)3.26023787
13T lymphocytopenia (HP:0005403)3.20772366
14Mediastinal lymphadenopathy (HP:0100721)3.18733362
15Chromsome breakage (HP:0040012)3.17415884
16Abnormality of T cell number (HP:0011839)3.15744282
17Orchitis (HP:0100796)3.07556838
18Abnormality of the fingertips (HP:0001211)3.05038679
19Abnormality of the heme biosynthetic pathway (HP:0010472)2.98525095
20Elevated erythrocyte sedimentation rate (HP:0003565)2.96762488
21Recurrent bacterial skin infections (HP:0005406)2.96623617
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95742697
23Severe combined immunodeficiency (HP:0004430)2.95396336
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.93241545
25IgM deficiency (HP:0002850)2.93092136
26Abnormality of chromosome stability (HP:0003220)2.88984193
27Hypoplasia of the fovea (HP:0007750)2.84564752
28Aplasia/Hypoplasia of the fovea (HP:0008060)2.84564752
29Chronic otitis media (HP:0000389)2.83930696
30Recurrent viral infections (HP:0004429)2.83623022
31Recurrent bronchitis (HP:0002837)2.74844404
32Abnormality of B cell number (HP:0010975)2.74729399
33B lymphocytopenia (HP:0010976)2.74729399
34Combined immunodeficiency (HP:0005387)2.70345084
35Gonadotropin excess (HP:0000837)2.70161987
36Parakeratosis (HP:0001036)2.69324138
37Ectopic kidney (HP:0000086)2.64838258
38Hypoplastic pelvis (HP:0008839)2.63525436
39Panhypogammaglobulinemia (HP:0003139)2.62859595
40Severe visual impairment (HP:0001141)2.62375141
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.59640119
42Duplicated collecting system (HP:0000081)2.55508810
43Abnormality of T cells (HP:0002843)2.54768548
44Rhabdomyosarcoma (HP:0002859)2.54312387
45Reduced antithrombin III activity (HP:0001976)2.53261831
46Metaphyseal dysplasia (HP:0100255)2.45006236
47Chronic diarrhea (HP:0002028)2.44611540
48Recurrent fungal infections (HP:0002841)2.44400120
49Meckel diverticulum (HP:0002245)2.43074758
50Abnormality of the fovea (HP:0000493)2.40811774
51Periodontitis (HP:0000704)2.40647191
52Adactyly (HP:0009776)2.40496789
53Abnormality of the ileum (HP:0001549)2.39760240
54Stomach cancer (HP:0012126)2.39252864
55Birth length less than 3rd percentile (HP:0003561)2.38850129
56Abnormal foot bone ossification (HP:0010675)2.38519459
57Keratoconjunctivitis sicca (HP:0001097)2.38241612
58Prominent metopic ridge (HP:0005487)2.37726735
59Reticulocytopenia (HP:0001896)2.36976561
60Amaurosis fugax (HP:0100576)2.34890484
61Abnormality of the preputium (HP:0100587)2.33759036
62Portal hypertension (HP:0001409)2.33629941
63Autoimmune hemolytic anemia (HP:0001890)2.33411884
64Lymphopenia (HP:0001888)2.32854338
65Vasculitis (HP:0002633)2.30823836
66Posterior subcapsular cataract (HP:0007787)2.28359145
67Meningitis (HP:0001287)2.25831716
68Gingival bleeding (HP:0000225)2.25163619
69IgG deficiency (HP:0004315)2.23703795
70Fatigue (HP:0012378)2.23385919
71Arterial thrombosis (HP:0004420)2.22718228
72Agammaglobulinemia (HP:0004432)2.21905310
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.21636165
74Granulocytopenia (HP:0001913)2.21147257
75Methylmalonic aciduria (HP:0012120)2.20580945
76Abnormality of macular pigmentation (HP:0008002)2.20536996
77Vitreoretinal degeneration (HP:0000655)2.20353076
78Inflammation of the large intestine (HP:0002037)2.18267724
79Vacuolated lymphocytes (HP:0001922)2.18203539
80Epistaxis (HP:0000421)2.17799637
81Type I transferrin isoform profile (HP:0003642)2.17527804
82Abnormal rod and cone electroretinograms (HP:0008323)2.17282208
83Thyroiditis (HP:0100646)2.16494640
84Abnormality of the prostate (HP:0008775)2.15753835
85Keratoconjunctivitis (HP:0001096)2.15496902
86Clubbing of toes (HP:0100760)2.15349232
87Fibular aplasia (HP:0002990)2.14026138
88Methylmalonic acidemia (HP:0002912)2.13906994
89Aplasia/hypoplasia of the uterus (HP:0008684)2.13757671
90Exertional dyspnea (HP:0002875)2.13520008
91Hypergonadotropic hypogonadism (HP:0000815)2.13468021
92Recurrent skin infections (HP:0001581)2.13042140
93Prolonged bleeding time (HP:0003010)2.12429236
94Petechiae (HP:0000967)2.11454661
95Eosinophilia (HP:0001880)2.11382925
96Spontaneous hematomas (HP:0007420)2.11290970
97Abnormality of the metopic suture (HP:0005556)2.09434288
98Abnormality of the hepatic vasculature (HP:0006707)2.08690956
99Prostate neoplasm (HP:0100787)2.08352372
100Abnormality of the renal collecting system (HP:0004742)2.06512382
101Lymphoma (HP:0002665)2.06427925
102IgA deficiency (HP:0002720)2.05853599
103Abnormal spermatogenesis (HP:0008669)2.05825098
104Humeroradial synostosis (HP:0003041)2.05382551
105Synostosis involving the elbow (HP:0003938)2.05382551
106Hypoplastic labia majora (HP:0000059)2.05347257
107Cervical subluxation (HP:0003308)2.03123517
108Central scotoma (HP:0000603)2.01862998
109Gastrointestinal inflammation (HP:0004386)2.01472107
110Oligodactyly (HP:0012165)2.01459805
111Recurrent pneumonia (HP:0006532)2.01424590
112Volvulus (HP:0002580)2.00662896
113Congenital stationary night blindness (HP:0007642)2.00063614
114Generalized hypopigmentation (HP:0007513)1.99276200
115Absent frontal sinuses (HP:0002688)1.98699682
116Flat capital femoral epiphysis (HP:0003370)1.98387972
117Hematochezia (HP:0002573)1.97994504
118Abnormality of T cell physiology (HP:0011840)1.97908048
119Abnormal platelet volume (HP:0011876)1.96682552
120Leukocytosis (HP:0001974)1.95478174
121Autoimmune thrombocytopenia (HP:0001973)1.95119506
122Osteomyelitis (HP:0002754)1.94919303
123Pulmonary infiltrates (HP:0002113)1.94660716
124Leukopenia (HP:0001882)1.92186771
125Azoospermia (HP:0000027)1.88757214
126Abnormality of pyrimidine metabolism (HP:0004353)1.88524391
127Carpal bone hypoplasia (HP:0001498)1.88217872
128Neutropenia (HP:0001875)1.86740942
129Abnormality of the costochondral junction (HP:0000919)1.86282918
130Aplasia/Hypoplasia of the macula (HP:0008059)1.85553550
131Abnormality of eosinophils (HP:0001879)1.82138917
132Metaphyseal irregularity (HP:0003025)1.82055707
133Recurrent sinusitis (HP:0011108)1.81133947
134Increased mean platelet volume (HP:0011877)1.80715869
135Encephalitis (HP:0002383)1.80480145
136Epiphyseal dysplasia (HP:0002656)1.80338020
137Abnormality of the labia majora (HP:0012881)1.80108016
138Abnormality of the labia minora (HP:0012880)1.80036155
139Agnosia (HP:0010524)1.78776961
140Delayed epiphyseal ossification (HP:0002663)1.78610300
141Abnormality of the pleura (HP:0002103)1.78455252
142Neoplasm of the small intestine (HP:0100833)1.78273597
143Hypoplastic iliac wings (HP:0002866)1.77311698
144Abnormality of DNA repair (HP:0003254)1.77212527
145Acute myeloid leukemia (HP:0004808)1.76864202
146Slender build (HP:0001533)1.75863087
147Flared metaphyses (HP:0003015)1.75718508
148Chronic mucocutaneous candidiasis (HP:0002728)1.74831867
149Recurrent cutaneous fungal infections (HP:0011370)1.74831867
150Type II lissencephaly (HP:0007260)1.72601065
151Scotoma (HP:0000575)1.72451962
152Abnormality of the vitamin B12 metabolism (HP:0004341)1.69618607
153Abnormal delayed hypersensitivity skin test (HP:0002963)1.67553527
154Disproportionate short-trunk short stature (HP:0003521)1.66444267
155Sloping forehead (HP:0000340)1.65804861
156Abnormality of vitamin B metabolism (HP:0004340)1.65737777
157Aplasia/Hypoplasia affecting the retina (HP:0008061)1.64942064
158Hypoplasia of the thymus (HP:0000778)1.64796414
159Increased serum lactate (HP:0002151)1.62459715
160Abnormality of serum amino acid levels (HP:0003112)1.61826029
161Small intestinal stenosis (HP:0012848)1.61457966
162Duodenal stenosis (HP:0100867)1.61457966
163Degeneration of anterior horn cells (HP:0002398)1.59924437
164Abnormality of the anterior horn cell (HP:0006802)1.59924437
165Neoplasm of striated muscle (HP:0009728)1.58999203
166Fair hair (HP:0002286)1.58953833
167Neoplasm of the rectum (HP:0100743)1.58886280
168Breast carcinoma (HP:0003002)1.58039515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK23.10187713
2MAP4K13.01624464
3MST42.39830361
4IRAK42.35100462
5MAP3K142.32331857
6MAP3K92.30294908
7TRIM282.23545486
8STK102.21733651
9TXK2.21637586
10JAK32.19394556
11TEC2.18369242
12ZAP702.14324893
13WNK32.08023679
14CSNK1G11.99999581
15BLK1.98642667
16ARAF1.94755302
17EIF2AK31.94529843
18FRK1.93220460
19IKBKB1.80198224
20MKNK11.79258728
21TGFBR21.74646124
22MAP3K131.72374276
23ADRBK21.71583121
24TBK11.70953718
25NUAK11.68387670
26ITK1.64371598
27BTK1.59454963
28IRAK31.57000407
29IKBKE1.54960297
30YES11.53618405
31CLK11.52820319
32WEE11.51486859
33KIT1.48475343
34CSF1R1.48406405
35TAOK31.46633935
36CSNK1G21.43254628
37SRPK11.42548649
38NLK1.42310542
39MARK31.41062189
40TYK21.39798989
41MUSK1.36601731
42AKT31.33152460
43PIM11.32941240
44SYK1.30942763
45MAP4K21.27062190
46TNIK1.26126433
47CSNK1G31.19242836
48TRPM71.18839577
49MAP3K41.16372969
50MKNK21.16025975
51PRKCI1.14596416
52LCK1.12887927
53CSNK1A1L1.12866150
54KDR1.12214064
55STK241.10261311
56ATR1.09446348
57RAF11.09337394
58BRAF1.08237332
59SGK21.06979967
60MOS1.04996607
61EIF2AK11.04130699
62PBK1.02082463
63BRSK11.01354458
64CDC71.00093948
65NEK20.99780338
66TIE10.95390500
67PKN10.94926956
68CDK60.94362732
69VRK10.91301317
70FGFR40.90774135
71PDK40.89855714
72PDK30.89855714
73CHUK0.89741332
74STK40.89673894
75EPHA30.87980771
76ZAK0.87480628
77FLT30.86925887
78MAPKAPK50.86276672
79MAPK130.85966322
80TSSK60.85690676
81CSK0.85451134
82MAPK110.85194815
83HCK0.85037441
84NEK90.82562938
85EPHB10.81950461
86DYRK20.81450866
87JAK10.80754876
88MAP2K30.80459128
89GRK70.80111032
90TAF10.80095386
91ACVR1B0.79291145
92LYN0.78952466
93STK30.75908919
94AURKB0.72345891
95PDK20.68615942
96CDK120.67615619
97TESK20.67556223
98BMPR20.67312129
99PLK30.67182824
100DYRK30.66679443
101SGK30.66312399
102INSRR0.65645486
103PNCK0.65024268
104KSR10.64150583
105TLK10.64148690
106IRAK10.61306049
107SIK30.61148496
108KSR20.59771906
109MAP3K120.58403170
110FGR0.58040201
111TTK0.55664760
112CHEK20.55422394
113PIM20.54685263
114PLK20.54525200
115CHEK10.54329065
116PTK2B0.54151771
117MELK0.53394729
118ATM0.53316437
119EPHA40.52613721
120PLK40.51918509
121PASK0.51593186
122GRK10.50717886
123RPS6KA40.50405507
124FGFR30.50245838
125IRAK20.48738759
126BCR0.48677865
127PRKCE0.46498178
128SGK2230.46392424
129SGK4940.46392424
130PIK3CA0.46331050
131CDK40.45920448
132ERBB30.45660051
133FER0.45439399
134MAP2K70.44286978
135EEF2K0.44281185
136MAP3K80.43790415
137PLK10.42844122
138RPS6KB20.42023060
139PRKG20.41287975
140BMPR1B0.41238445
141PDGFRB0.41183583
142IGF1R0.41165551
143EIF2AK20.39479164
144TGFBR10.39217556
145MAP3K30.38601749
146MAPKAPK20.38364641
147NME20.37296985
148GRK60.36941166
149MAPK30.36075847
150JAK20.35228439

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.74260065
2Non-homologous end-joining_Homo sapiens_hsa034502.72637673
3Regulation of autophagy_Homo sapiens_hsa041402.69664249
4Allograft rejection_Homo sapiens_hsa053302.67543630
5Graft-versus-host disease_Homo sapiens_hsa053322.51057899
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.47319590
7Antigen processing and presentation_Homo sapiens_hsa046122.45755524
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30860322
9DNA replication_Homo sapiens_hsa030302.25871205
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.13529812
11Homologous recombination_Homo sapiens_hsa034402.08600527
12Measles_Homo sapiens_hsa051622.04104542
13Base excision repair_Homo sapiens_hsa034101.96877438
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95727418
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.94826839
16Mismatch repair_Homo sapiens_hsa034301.90640714
17Leishmaniasis_Homo sapiens_hsa051401.89401210
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85655948
19Staphylococcus aureus infection_Homo sapiens_hsa051501.81349404
20Malaria_Homo sapiens_hsa051441.75992431
21Herpes simplex infection_Homo sapiens_hsa051681.73772107
22Proteasome_Homo sapiens_hsa030501.71781217
23Propanoate metabolism_Homo sapiens_hsa006401.67423675
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64671844
25Hematopoietic cell lineage_Homo sapiens_hsa046401.61716298
26T cell receptor signaling pathway_Homo sapiens_hsa046601.52411958
27RNA degradation_Homo sapiens_hsa030181.49640131
28Cell cycle_Homo sapiens_hsa041101.43496412
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41453226
30Legionellosis_Homo sapiens_hsa051341.37553685
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37090721
32Spliceosome_Homo sapiens_hsa030401.36182144
33Osteoclast differentiation_Homo sapiens_hsa043801.32874776
34Steroid biosynthesis_Homo sapiens_hsa001001.32849671
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.30663242
36Dorso-ventral axis formation_Homo sapiens_hsa043201.25639127
37Fanconi anemia pathway_Homo sapiens_hsa034601.24706376
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24377095
39One carbon pool by folate_Homo sapiens_hsa006701.24132257
40Fatty acid elongation_Homo sapiens_hsa000621.23200475
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20551073
42Basal transcription factors_Homo sapiens_hsa030221.18950057
43B cell receptor signaling pathway_Homo sapiens_hsa046621.17431962
44Nucleotide excision repair_Homo sapiens_hsa034201.13755435
45Influenza A_Homo sapiens_hsa051641.13457689
46RNA polymerase_Homo sapiens_hsa030201.12820811
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11758667
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10839325
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10757998
50Viral carcinogenesis_Homo sapiens_hsa052031.08862163
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07938505
52Epstein-Barr virus infection_Homo sapiens_hsa051691.07249311
53RNA transport_Homo sapiens_hsa030131.06933945
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04745011
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04408238
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04211139
57Apoptosis_Homo sapiens_hsa042101.02170198
58Systemic lupus erythematosus_Homo sapiens_hsa053221.01361621
59Hepatitis B_Homo sapiens_hsa051610.99457838
60p53 signaling pathway_Homo sapiens_hsa041150.98169146
61Autoimmune thyroid disease_Homo sapiens_hsa053200.92142371
62Toxoplasmosis_Homo sapiens_hsa051450.91730173
63Pentose phosphate pathway_Homo sapiens_hsa000300.90794246
64Type I diabetes mellitus_Homo sapiens_hsa049400.90678687
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89531377
66Linoleic acid metabolism_Homo sapiens_hsa005910.87850373
67Tuberculosis_Homo sapiens_hsa051520.87617281
68Pyrimidine metabolism_Homo sapiens_hsa002400.87183902
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86615382
70Pertussis_Homo sapiens_hsa051330.85471746
71Other glycan degradation_Homo sapiens_hsa005110.82354606
72Folate biosynthesis_Homo sapiens_hsa007900.80355778
73Caffeine metabolism_Homo sapiens_hsa002320.78833113
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.76450068
75HTLV-I infection_Homo sapiens_hsa051660.73864745
76Small cell lung cancer_Homo sapiens_hsa052220.73601643
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73568504
78Ether lipid metabolism_Homo sapiens_hsa005650.72646763
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71086653
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.70378774
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67672035
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65857281
83ABC transporters_Homo sapiens_hsa020100.65272779
84Asthma_Homo sapiens_hsa053100.65238208
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65177969
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64368969
87Phototransduction_Homo sapiens_hsa047440.64365825
88Shigellosis_Homo sapiens_hsa051310.62992200
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62400909
90African trypanosomiasis_Homo sapiens_hsa051430.62007585
91Hepatitis C_Homo sapiens_hsa051600.61822450
92Viral myocarditis_Homo sapiens_hsa054160.61780074
93TNF signaling pathway_Homo sapiens_hsa046680.60768664
94Complement and coagulation cascades_Homo sapiens_hsa046100.59582351
95Sphingolipid metabolism_Homo sapiens_hsa006000.58289574
96Purine metabolism_Homo sapiens_hsa002300.57544740
97Lysosome_Homo sapiens_hsa041420.55757544
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55115606
99MicroRNAs in cancer_Homo sapiens_hsa052060.54982842
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54731049
101Salmonella infection_Homo sapiens_hsa051320.54054916
102Protein export_Homo sapiens_hsa030600.53819223
103Chemokine signaling pathway_Homo sapiens_hsa040620.53403634
104Platelet activation_Homo sapiens_hsa046110.52524655
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50430995
106Selenocompound metabolism_Homo sapiens_hsa004500.49748377
107Rheumatoid arthritis_Homo sapiens_hsa053230.46627737
108Retinol metabolism_Homo sapiens_hsa008300.46486357
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.45687762
110ECM-receptor interaction_Homo sapiens_hsa045120.44712923
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44672106
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.41556482
113mRNA surveillance pathway_Homo sapiens_hsa030150.38107904
114Circadian rhythm_Homo sapiens_hsa047100.37151001
115Ribosome_Homo sapiens_hsa030100.37086639
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36617859
117Peroxisome_Homo sapiens_hsa041460.36319157
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36296390
119Chronic myeloid leukemia_Homo sapiens_hsa052200.34138500
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33830541
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33619974
122FoxO signaling pathway_Homo sapiens_hsa040680.33495885
123Hedgehog signaling pathway_Homo sapiens_hsa043400.32938367
124TGF-beta signaling pathway_Homo sapiens_hsa043500.32673455
125Tryptophan metabolism_Homo sapiens_hsa003800.32573645
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.32525337
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32091857
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32017584
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31915195
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31212589
131N-Glycan biosynthesis_Homo sapiens_hsa005100.30897382
132Metabolic pathways_Homo sapiens_hsa011000.26277739
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.23474987
134Acute myeloid leukemia_Homo sapiens_hsa052210.22896424

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