

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | presynaptic membrane assembly (GO:0097105) | 7.07543964 |
| 2 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 6.79362711 |
| 3 | presynaptic membrane organization (GO:0097090) | 6.41606094 |
| 4 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 6.07303721 |
| 5 | neuron cell-cell adhesion (GO:0007158) | 5.76141408 |
| 6 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 5.62082652 |
| 7 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.56207914 |
| 8 | glutamate secretion (GO:0014047) | 5.54295358 |
| 9 | protein localization to synapse (GO:0035418) | 5.52902057 |
| 10 | postsynaptic membrane organization (GO:0001941) | 5.41030814 |
| 11 | vocalization behavior (GO:0071625) | 5.34416130 |
| 12 | neurotransmitter-gated ion channel clustering (GO:0072578) | 5.27028746 |
| 13 | synaptic vesicle exocytosis (GO:0016079) | 5.00999631 |
| 14 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.00147425 |
| 15 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.99808389 |
| 16 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.88652659 |
| 17 | synaptic transmission, glutamatergic (GO:0035249) | 4.79019532 |
| 18 | glutamate receptor signaling pathway (GO:0007215) | 4.71604220 |
| 19 | cerebellar granule cell differentiation (GO:0021707) | 4.71327612 |
| 20 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.71040423 |
| 21 | neuronal action potential propagation (GO:0019227) | 4.65842562 |
| 22 | neuron-neuron synaptic transmission (GO:0007270) | 4.64747422 |
| 23 | positive regulation of neurotransmitter secretion (GO:0001956) | 4.57368336 |
| 24 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 4.42107386 |
| 25 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.37040422 |
| 26 | mechanosensory behavior (GO:0007638) | 4.30043997 |
| 27 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 4.27872612 |
| 28 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.27570113 |
| 29 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 4.25521795 |
| 30 | response to histamine (GO:0034776) | 4.24737498 |
| 31 | regulation of postsynaptic membrane potential (GO:0060078) | 4.16156008 |
| 32 | positive regulation of synapse maturation (GO:0090129) | 4.15792125 |
| 33 | regulation of synaptic vesicle transport (GO:1902803) | 4.12629580 |
| 34 | startle response (GO:0001964) | 4.06860501 |
| 35 | locomotory exploration behavior (GO:0035641) | 4.03538133 |
| 36 | long-term synaptic potentiation (GO:0060291) | 4.00677964 |
| 37 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.88344425 |
| 38 | regulation of synapse maturation (GO:0090128) | 3.85229698 |
| 39 | positive regulation of membrane potential (GO:0045838) | 3.81687807 |
| 40 | auditory behavior (GO:0031223) | 3.79335948 |
| 41 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.70813184 |
| 42 | positive regulation of neurotransmitter transport (GO:0051590) | 3.66564399 |
| 43 | regulation of neurotransmitter secretion (GO:0046928) | 3.61507706 |
| 44 | regulation of synaptic plasticity (GO:0048167) | 3.55912603 |
| 45 | neurotransmitter secretion (GO:0007269) | 3.53540203 |
| 46 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.50802586 |
| 47 | positive regulation of synapse assembly (GO:0051965) | 3.50371474 |
| 48 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.47845447 |
| 49 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.46840076 |
| 50 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.44844833 |
| 51 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.42416411 |
| 52 | synaptic vesicle endocytosis (GO:0048488) | 3.42210151 |
| 53 | neuron recognition (GO:0008038) | 3.39565288 |
| 54 | cellular potassium ion homeostasis (GO:0030007) | 3.36741105 |
| 55 | membrane assembly (GO:0071709) | 3.35176952 |
| 56 | membrane depolarization (GO:0051899) | 3.31484949 |
| 57 | behavioral response to cocaine (GO:0048148) | 3.31053369 |
| 58 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.30872273 |
| 59 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.30863929 |
| 60 | long-term memory (GO:0007616) | 3.30384896 |
| 61 | synaptic vesicle maturation (GO:0016188) | 3.30197535 |
| 62 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.29503760 |
| 63 | serotonin metabolic process (GO:0042428) | 3.28207337 |
| 64 | regulation of dendritic spine development (GO:0060998) | 3.27641184 |
| 65 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.27268247 |
| 66 | axonal fasciculation (GO:0007413) | 3.26374072 |
| 67 | positive regulation of cardiac muscle cell differentiation (GO:2000727) | 3.25246089 |
| 68 | regulation of glutamate secretion (GO:0014048) | 3.22572497 |
| 69 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.21482902 |
| 70 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.21143946 |
| 71 | regulation of synapse assembly (GO:0051963) | 3.18328889 |
| 72 | exploration behavior (GO:0035640) | 3.16795868 |
| 73 | positive regulation of dendritic spine development (GO:0060999) | 3.14252440 |
| 74 | regulation of neurotransmitter transport (GO:0051588) | 3.13257698 |
| 75 | negative regulation of neurotransmitter transport (GO:0051589) | 3.11938515 |
| 76 | transmission of nerve impulse (GO:0019226) | 3.09798901 |
| 77 | positive regulation of synaptic transmission (GO:0050806) | 3.08430997 |
| 78 | regulation of vesicle fusion (GO:0031338) | 3.07375586 |
| 79 | regulation of respiratory system process (GO:0044065) | 3.07161491 |
| 80 | vesicle docking involved in exocytosis (GO:0006904) | 3.06088948 |
| 81 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.05412716 |
| 82 | learning (GO:0007612) | 3.04667942 |
| 83 | atrial cardiac muscle cell action potential (GO:0086014) | 3.01370124 |
| 84 | negative regulation of dendrite development (GO:2000171) | 3.00195789 |
| 85 | response to auditory stimulus (GO:0010996) | 2.96556469 |
| 86 | calcium ion-dependent exocytosis (GO:0017156) | 2.95763219 |
| 87 | membrane depolarization during action potential (GO:0086010) | 2.95111755 |
| 88 | fear response (GO:0042596) | 2.93859415 |
| 89 | vesicle docking (GO:0048278) | 2.93592915 |
| 90 | phosphorelay signal transduction system (GO:0000160) | 2.91372622 |
| 91 | neurotransmitter transport (GO:0006836) | 2.90701536 |
| 92 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.90664424 |
| 93 | L-amino acid import (GO:0043092) | 2.89815667 |
| 94 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.89390810 |
| 95 | cochlea development (GO:0090102) | 2.89373447 |
| 96 | regulation of synaptic transmission (GO:0050804) | 2.88270504 |
| 97 | negative regulation of amino acid transport (GO:0051956) | 2.88149134 |
| 98 | synapse assembly (GO:0007416) | 2.87713030 |
| 99 | behavioral defense response (GO:0002209) | 2.87684071 |
| 100 | behavioral fear response (GO:0001662) | 2.87684071 |
| 101 | membrane hyperpolarization (GO:0060081) | 2.85476384 |
| 102 | synaptic transmission (GO:0007268) | 2.85472948 |
| 103 | righting reflex (GO:0060013) | 2.84986345 |
| 104 | cell differentiation in hindbrain (GO:0021533) | 2.80913651 |
| 105 | regulation of synapse organization (GO:0050807) | 2.80557057 |
| 106 | gamma-aminobutyric acid transport (GO:0015812) | 2.79780563 |
| 107 | urinary tract smooth muscle contraction (GO:0014848) | 2.78699667 |
| 108 | positive regulation of protein homodimerization activity (GO:0090073) | 2.78585813 |
| 109 | primary amino compound metabolic process (GO:1901160) | 2.77182661 |
| 110 | regulation of neurotransmitter levels (GO:0001505) | 2.74761430 |
| 111 | sodium ion export (GO:0071436) | 2.70123540 |
| 112 | neuromuscular synaptic transmission (GO:0007274) | 2.67892404 |
| 113 | proline transport (GO:0015824) | 2.64216361 |
| 114 | regulation of sarcomere organization (GO:0060297) | 2.61733849 |
| 115 | social behavior (GO:0035176) | 2.57633271 |
| 116 | intraspecies interaction between organisms (GO:0051703) | 2.57633271 |
| 117 | dendritic spine morphogenesis (GO:0060997) | 2.55200446 |
| 118 | potassium ion import (GO:0010107) | 2.54356465 |
| 119 | mitotic sister chromatid cohesion (GO:0007064) | 2.53200068 |
| 120 | C4-dicarboxylate transport (GO:0015740) | 2.50826968 |
| 121 | microtubule polymerization or depolymerization (GO:0031109) | 2.49318321 |
| 122 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.43058045 |
| 123 | positive regulation of dendrite morphogenesis (GO:0050775) | 2.42786217 |
| 124 | potassium ion homeostasis (GO:0055075) | 2.42488893 |
| 125 | regulation of dendrite morphogenesis (GO:0048814) | 2.42367904 |
| 126 | dendrite morphogenesis (GO:0048813) | 2.40148060 |
| 127 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.39537472 |
| 128 | regulation of centriole replication (GO:0046599) | 2.38262029 |
| 129 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.36135646 |
| 130 | neuronal ion channel clustering (GO:0045161) | 2.35733128 |
| 131 | regulation of synapse structural plasticity (GO:0051823) | 2.35496473 |
| 132 | microtubule depolymerization (GO:0007019) | 2.35298293 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GBX2_23144817_ChIP-Seq_PC3_Human | 5.21464801 |
| 2 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.85630561 |
| 3 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.83982363 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.77201770 |
| 5 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.76299291 |
| 6 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.65244099 |
| 7 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.60139707 |
| 8 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.49205022 |
| 9 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.47742638 |
| 10 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.37369904 |
| 11 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.30816263 |
| 12 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 2.29793479 |
| 13 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.29192503 |
| 14 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.24296295 |
| 15 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.23844169 |
| 16 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.17498322 |
| 17 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.17173571 |
| 18 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.15671970 |
| 19 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.15037906 |
| 20 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.14089443 |
| 21 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.14089443 |
| 22 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.12380534 |
| 23 | * POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.10286191 |
| 24 | FUS_26573619_Chip-Seq_HEK293_Human | 2.08752091 |
| 25 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.07821247 |
| 26 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.05527339 |
| 27 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.04421444 |
| 28 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.02425967 |
| 29 | P300_19829295_ChIP-Seq_ESCs_Human | 2.02111507 |
| 30 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.01366006 |
| 31 | SMAD4_21799915_ChIP-Seq_A2780_Human | 2.00183648 |
| 32 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.95572610 |
| 33 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.93375334 |
| 34 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.92220039 |
| 35 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.91857281 |
| 36 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.91287954 |
| 37 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.90767530 |
| 38 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.90382927 |
| 39 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.80082727 |
| 40 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.77460167 |
| 41 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.72358933 |
| 42 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.71710764 |
| 43 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.68706892 |
| 44 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.66316196 |
| 45 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.65638824 |
| 46 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.64332162 |
| 47 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.63804144 |
| 48 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.62980481 |
| 49 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.62273205 |
| 50 | VDR_22108803_ChIP-Seq_LS180_Human | 1.62041241 |
| 51 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.61672856 |
| 52 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.59524004 |
| 53 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.57998853 |
| 54 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.57754018 |
| 55 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.57537970 |
| 56 | STAT3_23295773_ChIP-Seq_U87_Human | 1.56098648 |
| 57 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.54961817 |
| 58 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.54074756 |
| 59 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.54052570 |
| 60 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.51714121 |
| 61 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.47359624 |
| 62 | * NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.47356043 |
| 63 | * TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.46675040 |
| 64 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.44657285 |
| 65 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.44105326 |
| 66 | AR_25329375_ChIP-Seq_VCAP_Human | 1.43858961 |
| 67 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.43048972 |
| 68 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.42516077 |
| 69 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.41352387 |
| 70 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.40473091 |
| 71 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.38502829 |
| 72 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.35716494 |
| 73 | * E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.34905442 |
| 74 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.34220712 |
| 75 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.33566131 |
| 76 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.32191919 |
| 77 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.31896401 |
| 78 | TP53_16413492_ChIP-PET_HCT116_Human | 1.31818957 |
| 79 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.31335455 |
| 80 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.30440791 |
| 81 | * EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.30048203 |
| 82 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.29874594 |
| 83 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.29874594 |
| 84 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.29478540 |
| 85 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.28890495 |
| 86 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.27173280 |
| 87 | * P53_22387025_ChIP-Seq_ESCs_Mouse | 1.26740340 |
| 88 | EWS_26573619_Chip-Seq_HEK293_Human | 1.24934141 |
| 89 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.24473110 |
| 90 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.21867223 |
| 91 | * CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.21797121 |
| 92 | * SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.18128128 |
| 93 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.17669812 |
| 94 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.17534293 |
| 95 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.17402059 |
| 96 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.16984632 |
| 97 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.16843536 |
| 98 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.15540634 |
| 99 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.14149456 |
| 100 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.13168097 |
| 101 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11333842 |
| 102 | * SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.11152726 |
| 103 | JUN_21703547_ChIP-Seq_K562_Human | 1.10479935 |
| 104 | * P300_18555785_Chip-Seq_ESCs_Mouse | 1.10380508 |
| 105 | * SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.09323824 |
| 106 | * EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.08526547 |
| 107 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.08504557 |
| 108 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.08504557 |
| 109 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.08194897 |
| 110 | * AR_19668381_ChIP-Seq_PC3_Human | 1.08026714 |
| 111 | * STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.07851925 |
| 112 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.07816142 |
| 113 | KDM2B_26808549_Chip-Seq_REH_Human | 1.07018964 |
| 114 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.06743339 |
| 115 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.06357773 |
| 116 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.05398488 |
| 117 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.04559249 |
| 118 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.04406505 |
| 119 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.02133866 |
| 120 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.01319270 |
| 121 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.98089593 |
| 122 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.96901326 |
| 123 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96529545 |
| 124 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.96047979 |
| 125 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.95471303 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 6.22074141 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 5.35450984 |
| 3 | MP0004270_analgesia | 3.76851713 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.75972236 |
| 5 | MP0009745_abnormal_behavioral_response | 3.48299305 |
| 6 | MP0001968_abnormal_touch/_nociception | 3.47715002 |
| 7 | MP0002063_abnormal_learning/memory/cond | 3.14364019 |
| 8 | MP0002064_seizures | 3.13115838 |
| 9 | MP0009046_muscle_twitch | 3.04468302 |
| 10 | MP0002736_abnormal_nociception_after | 3.01788446 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 2.93634007 |
| 12 | MP0003787_abnormal_imprinting | 2.66320985 |
| 13 | MP0002272_abnormal_nervous_system | 2.57299205 |
| 14 | MP0002734_abnormal_mechanical_nocicepti | 2.52302832 |
| 15 | MP0001486_abnormal_startle_reflex | 2.50515841 |
| 16 | MP0002735_abnormal_chemical_nociception | 2.48702508 |
| 17 | MP0009780_abnormal_chondrocyte_physiolo | 2.39049521 |
| 18 | MP0002067_abnormal_sensory_capabilities | 2.24154073 |
| 19 | MP0001440_abnormal_grooming_behavior | 2.20912346 |
| 20 | MP0001188_hyperpigmentation | 2.18666387 |
| 21 | MP0001501_abnormal_sleep_pattern | 2.18413584 |
| 22 | MP0005646_abnormal_pituitary_gland | 2.13389784 |
| 23 | MP0008057_abnormal_DNA_replication | 2.05591106 |
| 24 | MP0003879_abnormal_hair_cell | 2.05291632 |
| 25 | MP0000778_abnormal_nervous_system | 1.87863710 |
| 26 | MP0005423_abnormal_somatic_nervous | 1.86488929 |
| 27 | MP0005386_behavior/neurological_phenoty | 1.71641372 |
| 28 | MP0004924_abnormal_behavior | 1.71641372 |
| 29 | MP0005171_absent_coat_pigmentation | 1.69973120 |
| 30 | MP0002557_abnormal_social/conspecific_i | 1.67315880 |
| 31 | MP0005409_darkened_coat_color | 1.66354376 |
| 32 | MP0001502_abnormal_circadian_rhythm | 1.63223658 |
| 33 | MP0001970_abnormal_pain_threshold | 1.61700071 |
| 34 | MP0002733_abnormal_thermal_nociception | 1.56279363 |
| 35 | MP0010094_abnormal_chromosome_stability | 1.48866791 |
| 36 | MP0008569_lethality_at_weaning | 1.46212382 |
| 37 | MP0002184_abnormal_innervation | 1.46150718 |
| 38 | MP0008877_abnormal_DNA_methylation | 1.45289616 |
| 39 | MP0003890_abnormal_embryonic-extraembry | 1.45239992 |
| 40 | MP0004145_abnormal_muscle_electrophysio | 1.44353644 |
| 41 | MP0001529_abnormal_vocalization | 1.42378996 |
| 42 | MP0002822_catalepsy | 1.40826037 |
| 43 | MP0004742_abnormal_vestibular_system | 1.40780651 |
| 44 | MP0002876_abnormal_thyroid_physiology | 1.39416182 |
| 45 | MP0006276_abnormal_autonomic_nervous | 1.35224697 |
| 46 | MP0001905_abnormal_dopamine_level | 1.34051537 |
| 47 | MP0001984_abnormal_olfaction | 1.33482003 |
| 48 | MP0004811_abnormal_neuron_physiology | 1.30892104 |
| 49 | MP0000569_abnormal_digit_pigmentation | 1.30168848 |
| 50 | MP0002234_abnormal_pharynx_morphology | 1.29929126 |
| 51 | MP0002066_abnormal_motor_capabilities/c | 1.26675907 |
| 52 | MP0003633_abnormal_nervous_system | 1.25249592 |
| 53 | MP0002882_abnormal_neuron_morphology | 1.23899699 |
| 54 | MP0000955_abnormal_spinal_cord | 1.22899885 |
| 55 | MP0004142_abnormal_muscle_tone | 1.21642913 |
| 56 | MP0003122_maternal_imprinting | 1.20415177 |
| 57 | MP0003136_yellow_coat_color | 1.20074093 |
| 58 | MP0001485_abnormal_pinna_reflex | 1.19197533 |
| 59 | MP0006292_abnormal_olfactory_placode | 1.16338679 |
| 60 | MP0008058_abnormal_DNA_repair | 1.16331029 |
| 61 | MP0001963_abnormal_hearing_physiology | 1.14067736 |
| 62 | MP0003111_abnormal_nucleus_morphology | 1.12047046 |
| 63 | MP0003631_nervous_system_phenotype | 1.10358990 |
| 64 | MP0005645_abnormal_hypothalamus_physiol | 1.07795625 |
| 65 | MP0000015_abnormal_ear_pigmentation | 1.06403438 |
| 66 | MP0003861_abnormal_nervous_system | 1.05211147 |
| 67 | MP0002638_abnormal_pupillary_reflex | 1.00800978 |
| 68 | MP0005551_abnormal_eye_electrophysiolog | 1.00735880 |
| 69 | MP0002152_abnormal_brain_morphology | 0.96858215 |
| 70 | MP0004885_abnormal_endolymph | 0.96704808 |
| 71 | MP0003121_genomic_imprinting | 0.94687884 |
| 72 | MP0003183_abnormal_peptide_metabolism | 0.92044101 |
| 73 | MP0002229_neurodegeneration | 0.90950196 |
| 74 | MP0000751_myopathy | 0.90231295 |
| 75 | MP0000631_abnormal_neuroendocrine_gland | 0.89467712 |
| 76 | MP0003329_amyloid_beta_deposits | 0.86581551 |
| 77 | MP0001346_abnormal_lacrimal_gland | 0.83233223 |
| 78 | MP0002837_dystrophic_cardiac_calcinosis | 0.82476342 |
| 79 | MP0003693_abnormal_embryo_hatching | 0.79058114 |
| 80 | MP0010386_abnormal_urinary_bladder | 0.78748939 |
| 81 | MP0000026_abnormal_inner_ear | 0.77257503 |
| 82 | MP0000920_abnormal_myelination | 0.76640777 |
| 83 | MP0004085_abnormal_heartbeat | 0.76376004 |
| 84 | MP0001929_abnormal_gametogenesis | 0.76326077 |
| 85 | MP0003119_abnormal_digestive_system | 0.76278742 |
| 86 | MP0002210_abnormal_sex_determination | 0.75760956 |
| 87 | MP0008872_abnormal_physiological_respon | 0.74097065 |
| 88 | MP0004484_altered_response_of | 0.73851157 |
| 89 | MP0008874_decreased_physiological_sensi | 0.73733471 |
| 90 | MP0002752_abnormal_somatic_nervous | 0.73135033 |
| 91 | MP0006072_abnormal_retinal_apoptosis | 0.72994985 |
| 92 | MP0001664_abnormal_digestion | 0.71985749 |
| 93 | MP0003632_abnormal_nervous_system | 0.71914920 |
| 94 | MP0003077_abnormal_cell_cycle | 0.71738556 |
| 95 | MP0002069_abnormal_eating/drinking_beha | 0.71104980 |
| 96 | MP0005174_abnormal_tail_pigmentation | 0.70895883 |
| 97 | MP0002081_perinatal_lethality | 0.70612369 |
| 98 | MP0002751_abnormal_autonomic_nervous | 0.70154263 |
| 99 | MP0008932_abnormal_embryonic_tissue | 0.69616277 |
| 100 | MP0003137_abnormal_impulse_conducting | 0.69533830 |
| 101 | MP0006035_abnormal_mitochondrial_morpho | 0.69494530 |
| 102 | MP0004957_abnormal_blastocyst_morpholog | 0.68557619 |
| 103 | MP0008004_abnormal_stomach_pH | 0.66760002 |
| 104 | MP0004043_abnormal_pH_regulation | 0.66732209 |
| 105 | MP0005253_abnormal_eye_physiology | 0.66509893 |
| 106 | MP0004215_abnormal_myocardial_fiber | 0.65666882 |
| 107 | MP0001177_atelectasis | 0.65386066 |
| 108 | MP0009672_abnormal_birth_weight | 0.65332348 |
| 109 | MP0003937_abnormal_limbs/digits/tail_de | 0.64029679 |
| 110 | MP0003123_paternal_imprinting | 0.62568953 |
| 111 | MP0002102_abnormal_ear_morphology | 0.61620075 |
| 112 | MP0001943_abnormal_respiration | 0.59402584 |
| 113 | MP0002909_abnormal_adrenal_gland | 0.58534247 |
| 114 | MP0010770_preweaning_lethality | 0.57533056 |
| 115 | MP0002082_postnatal_lethality | 0.57533056 |
| 116 | MP0004858_abnormal_nervous_system | 0.56665291 |
| 117 | MP0003938_abnormal_ear_development | 0.55534960 |
| 118 | MP0010769_abnormal_survival | 0.54441633 |
| 119 | MP0010768_mortality/aging | 0.52776683 |
| 120 | MP0005499_abnormal_olfactory_system | 0.52705542 |
| 121 | MP0005394_taste/olfaction_phenotype | 0.52705542 |
| 122 | MP0003690_abnormal_glial_cell | 0.51844090 |
| 123 | MP0003698_abnormal_male_reproductive | 0.51392989 |
| 124 | MP0004147_increased_porphyrin_level | 0.51189734 |
| 125 | MP0005410_abnormal_fertilization | 0.50365112 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 8.48606862 |
| 2 | Epileptic encephalopathy (HP:0200134) | 7.05657585 |
| 3 | Hyperventilation (HP:0002883) | 6.74414245 |
| 4 | Atonic seizures (HP:0010819) | 5.99266927 |
| 5 | Febrile seizures (HP:0002373) | 5.60650341 |
| 6 | Focal seizures (HP:0007359) | 5.28660484 |
| 7 | Broad-based gait (HP:0002136) | 5.10536304 |
| 8 | Protruding tongue (HP:0010808) | 4.44019541 |
| 9 | Absence seizures (HP:0002121) | 4.18678213 |
| 10 | Gaze-evoked nystagmus (HP:0000640) | 4.16682153 |
| 11 | Dialeptic seizures (HP:0011146) | 4.08977555 |
| 12 | Drooling (HP:0002307) | 3.56309437 |
| 13 | Excessive salivation (HP:0003781) | 3.56309437 |
| 14 | Abnormal hair whorl (HP:0010721) | 3.52489215 |
| 15 | Myokymia (HP:0002411) | 3.48380252 |
| 16 | Progressive cerebellar ataxia (HP:0002073) | 3.44872273 |
| 17 | Generalized tonic-clonic seizures (HP:0002069) | 3.36073359 |
| 18 | Poor eye contact (HP:0000817) | 3.15796020 |
| 19 | Blue irides (HP:0000635) | 3.12371968 |
| 20 | Volvulus (HP:0002580) | 3.05921289 |
| 21 | Fair hair (HP:0002286) | 3.03932781 |
| 22 | Absent speech (HP:0001344) | 2.98132513 |
| 23 | Visual hallucinations (HP:0002367) | 2.90742031 |
| 24 | Sensory axonal neuropathy (HP:0003390) | 2.90471741 |
| 25 | Amblyopia (HP:0000646) | 2.88081477 |
| 26 | Birth length less than 3rd percentile (HP:0003561) | 2.84043031 |
| 27 | Inability to walk (HP:0002540) | 2.80023838 |
| 28 | Generalized hypopigmentation of hair (HP:0011358) | 2.69072780 |
| 29 | Epileptiform EEG discharges (HP:0011182) | 2.67510560 |
| 30 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.67020002 |
| 31 | Dysdiadochokinesis (HP:0002075) | 2.60722210 |
| 32 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.60146116 |
| 33 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.60146116 |
| 34 | Dysmetric saccades (HP:0000641) | 2.57669821 |
| 35 | Impaired smooth pursuit (HP:0007772) | 2.57333505 |
| 36 | Truncal ataxia (HP:0002078) | 2.53667476 |
| 37 | Absent/shortened dynein arms (HP:0200106) | 2.50304552 |
| 38 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.50304552 |
| 39 | Dysmetria (HP:0001310) | 2.50074763 |
| 40 | Impaired social interactions (HP:0000735) | 2.48444797 |
| 41 | Abnormal social behavior (HP:0012433) | 2.48444797 |
| 42 | Scanning speech (HP:0002168) | 2.47814872 |
| 43 | Abnormality of salivation (HP:0100755) | 2.46980753 |
| 44 | Urinary urgency (HP:0000012) | 2.45225578 |
| 45 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.37377523 |
| 46 | Stereotypic behavior (HP:0000733) | 2.34676017 |
| 47 | Genetic anticipation (HP:0003743) | 2.31961516 |
| 48 | Abnormality of the corticospinal tract (HP:0002492) | 2.30453052 |
| 49 | Widely spaced teeth (HP:0000687) | 2.30284662 |
| 50 | Gastroesophageal reflux (HP:0002020) | 2.29587983 |
| 51 | Fetal akinesia sequence (HP:0001989) | 2.29244493 |
| 52 | Gait imbalance (HP:0002141) | 2.27910388 |
| 53 | Medial flaring of the eyebrow (HP:0010747) | 2.26849941 |
| 54 | Thickened helices (HP:0000391) | 2.26136394 |
| 55 | Chronic hepatic failure (HP:0100626) | 2.22796667 |
| 56 | Chromsome breakage (HP:0040012) | 2.16582625 |
| 57 | Abnormality of the labia minora (HP:0012880) | 2.15006825 |
| 58 | EEG with generalized epileptiform discharges (HP:0011198) | 2.11278294 |
| 59 | Lissencephaly (HP:0001339) | 2.10695485 |
| 60 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.10556710 |
| 61 | Congenital primary aphakia (HP:0007707) | 2.10137907 |
| 62 | Nephrogenic diabetes insipidus (HP:0009806) | 2.09904372 |
| 63 | Colon cancer (HP:0003003) | 2.07650816 |
| 64 | Impaired vibratory sensation (HP:0002495) | 2.07482263 |
| 65 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.05736457 |
| 66 | Limb dystonia (HP:0002451) | 2.04771147 |
| 67 | Abnormal eating behavior (HP:0100738) | 2.04059240 |
| 68 | Termporal pattern (HP:0011008) | 2.02652144 |
| 69 | Insidious onset (HP:0003587) | 2.02652144 |
| 70 | Patellar aplasia (HP:0006443) | 2.02038452 |
| 71 | Hyperthyroidism (HP:0000836) | 2.00544115 |
| 72 | Retinal dysplasia (HP:0007973) | 1.99700471 |
| 73 | Hemiparesis (HP:0001269) | 1.99092743 |
| 74 | Abnormality of the astrocytes (HP:0100707) | 1.98409230 |
| 75 | Astrocytoma (HP:0009592) | 1.98409230 |
| 76 | Type II lissencephaly (HP:0007260) | 1.97992033 |
| 77 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.96594863 |
| 78 | Ankle clonus (HP:0011448) | 1.94555787 |
| 79 | Spastic gait (HP:0002064) | 1.94180078 |
| 80 | Deeply set eye (HP:0000490) | 1.93625654 |
| 81 | Clumsiness (HP:0002312) | 1.93469324 |
| 82 | Open mouth (HP:0000194) | 1.93196883 |
| 83 | Poor coordination (HP:0002370) | 1.86531727 |
| 84 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.85736450 |
| 85 | Exotropia (HP:0000577) | 1.83759439 |
| 86 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.83697008 |
| 87 | Lower limb amyotrophy (HP:0007210) | 1.83247603 |
| 88 | Nonprogressive disorder (HP:0003680) | 1.82867215 |
| 89 | Glioma (HP:0009733) | 1.81792612 |
| 90 | Hypsarrhythmia (HP:0002521) | 1.81384764 |
| 91 | Narrow nasal bridge (HP:0000446) | 1.81033292 |
| 92 | Diplopia (HP:0000651) | 1.80947114 |
| 93 | Abnormality of binocular vision (HP:0011514) | 1.80947114 |
| 94 | Neoplasm of the oral cavity (HP:0100649) | 1.80297376 |
| 95 | Inappropriate behavior (HP:0000719) | 1.80295016 |
| 96 | Oligodactyly (hands) (HP:0001180) | 1.79332740 |
| 97 | Obsessive-compulsive behavior (HP:0000722) | 1.79306958 |
| 98 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.79205551 |
| 99 | Increased nuchal translucency (HP:0010880) | 1.77776724 |
| 100 | Cerebral hypomyelination (HP:0006808) | 1.74995364 |
| 101 | Generalized myoclonic seizures (HP:0002123) | 1.73332106 |
| 102 | Specific learning disability (HP:0001328) | 1.72711756 |
| 103 | Progressive inability to walk (HP:0002505) | 1.71390770 |
| 104 | Thyroid-stimulating hormone excess (HP:0002925) | 1.70702143 |
| 105 | Short chin (HP:0000331) | 1.70289698 |
| 106 | Genital tract atresia (HP:0001827) | 1.70054136 |
| 107 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.69497903 |
| 108 | Postural instability (HP:0002172) | 1.69330050 |
| 109 | Incomplete penetrance (HP:0003829) | 1.68053924 |
| 110 | Spastic tetraplegia (HP:0002510) | 1.67590013 |
| 111 | Megalencephaly (HP:0001355) | 1.67290046 |
| 112 | Status epilepticus (HP:0002133) | 1.66915174 |
| 113 | Submucous cleft hard palate (HP:0000176) | 1.66558111 |
| 114 | Lower limb muscle weakness (HP:0007340) | 1.66133517 |
| 115 | Polyphagia (HP:0002591) | 1.66057218 |
| 116 | Action tremor (HP:0002345) | 1.65615108 |
| 117 | Intellectual disability, severe (HP:0010864) | 1.65440590 |
| 118 | Abnormality of chromosome stability (HP:0003220) | 1.65239617 |
| 119 | Meckel diverticulum (HP:0002245) | 1.65204139 |
| 120 | Anxiety (HP:0000739) | 1.65149179 |
| 121 | Depression (HP:0000716) | 1.64961646 |
| 122 | Akinesia (HP:0002304) | 1.64863729 |
| 123 | Gait ataxia (HP:0002066) | 1.64535535 |
| 124 | Intellectual disability, profound (HP:0002187) | 1.64431194 |
| 125 | Pheochromocytoma (HP:0002666) | 1.64128151 |
| 126 | Vaginal atresia (HP:0000148) | 1.63688705 |
| 127 | Abnormal ciliary motility (HP:0012262) | 1.63342533 |
| 128 | Distal lower limb amyotrophy (HP:0008944) | 1.62706437 |
| 129 | Nephronophthisis (HP:0000090) | 1.61972973 |
| 130 | Autism (HP:0000717) | 1.59950114 |
| 131 | Supranuclear gaze palsy (HP:0000605) | 1.59108768 |
| 132 | Abnormality of the ileum (HP:0001549) | 1.58954468 |
| 133 | Papillary thyroid carcinoma (HP:0002895) | 1.58166160 |
| 134 | Abnormality of midbrain morphology (HP:0002418) | 1.56760545 |
| 135 | Molar tooth sign on MRI (HP:0002419) | 1.56760545 |
| 136 | Medulloblastoma (HP:0002885) | 1.56642219 |
| 137 | Ectopic kidney (HP:0000086) | 1.56469559 |
| 138 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.54967441 |
| 139 | Attention deficit hyperactivity disorder (HP:0007018) | 1.52982713 |
| 140 | Embryonal renal neoplasm (HP:0011794) | 1.52424464 |
| 141 | CNS hypomyelination (HP:0003429) | 1.51866526 |
| 142 | Hepatoblastoma (HP:0002884) | 1.48497870 |
| 143 | Abnormality of chromosome segregation (HP:0002916) | 1.47470230 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CASK | 7.24711602 |
| 2 | EPHA4 | 4.31408737 |
| 3 | NTRK3 | 3.61129990 |
| 4 | DAPK2 | 3.44045553 |
| 5 | TNIK | 3.28368706 |
| 6 | CCNB1 | 3.01394123 |
| 7 | CDK19 | 2.98516270 |
| 8 | MAP2K7 | 2.85807277 |
| 9 | AKT3 | 2.65277372 |
| 10 | MAP3K4 | 2.54906863 |
| 11 | PLK2 | 2.37419368 |
| 12 | PRPF4B | 2.26250346 |
| 13 | DAPK1 | 2.24347018 |
| 14 | OXSR1 | 2.05278772 |
| 15 | FRK | 1.95182973 |
| 16 | MKNK2 | 1.88931064 |
| 17 | CDC7 | 1.86412631 |
| 18 | MAP3K12 | 1.81421655 |
| 19 | MAPK13 | 1.50522866 |
| 20 | RIPK4 | 1.47438997 |
| 21 | BMPR1B | 1.44461095 |
| 22 | MAP3K9 | 1.42328668 |
| 23 | MAP2K4 | 1.38137830 |
| 24 | WNK3 | 1.33560558 |
| 25 | SIK3 | 1.33163459 |
| 26 | CDK12 | 1.24658706 |
| 27 | PLK4 | 1.22913560 |
| 28 | CAMKK2 | 1.22718389 |
| 29 | SGK2 | 1.22556820 |
| 30 | CAMK1D | 1.20502134 |
| 31 | MARK1 | 1.15735539 |
| 32 | PTK2B | 1.10820006 |
| 33 | MINK1 | 1.08000543 |
| 34 | SGK494 | 1.07982021 |
| 35 | SGK223 | 1.07982021 |
| 36 | PAK6 | 1.05003590 |
| 37 | CDK3 | 1.04354393 |
| 38 | PNCK | 1.03161235 |
| 39 | CAMK2A | 1.02432492 |
| 40 | BMPR2 | 1.02229356 |
| 41 | CDK5 | 1.01965006 |
| 42 | NUAK1 | 1.01228846 |
| 43 | CAMK2B | 1.00756965 |
| 44 | PINK1 | 0.99428734 |
| 45 | PRKCG | 0.98441565 |
| 46 | WNK4 | 0.97467348 |
| 47 | KSR1 | 0.95549286 |
| 48 | MAPK7 | 0.93616450 |
| 49 | BRSK1 | 0.93507002 |
| 50 | NEK6 | 0.92006158 |
| 51 | TYRO3 | 0.89351795 |
| 52 | GRK5 | 0.89011954 |
| 53 | NEK1 | 0.88599009 |
| 54 | NTRK2 | 0.87535980 |
| 55 | PHKG2 | 0.84937915 |
| 56 | PHKG1 | 0.84937915 |
| 57 | TTK | 0.82576975 |
| 58 | TRIM28 | 0.82183245 |
| 59 | SGK1 | 0.81873076 |
| 60 | EIF2AK1 | 0.81700801 |
| 61 | PAK3 | 0.81233858 |
| 62 | MKNK1 | 0.81232401 |
| 63 | PLK3 | 0.80664430 |
| 64 | SIK2 | 0.80134122 |
| 65 | SGK3 | 0.78348166 |
| 66 | BRAF | 0.76553512 |
| 67 | ALK | 0.75263478 |
| 68 | BCR | 0.73309331 |
| 69 | WEE1 | 0.72971230 |
| 70 | SRPK1 | 0.72639992 |
| 71 | CAMKK1 | 0.69786476 |
| 72 | ATR | 0.69056223 |
| 73 | FES | 0.68775897 |
| 74 | PLK1 | 0.67214324 |
| 75 | FGR | 0.66362934 |
| 76 | PIK3CA | 0.65855961 |
| 77 | ACVR1B | 0.65350517 |
| 78 | MAP3K13 | 0.65326733 |
| 79 | CSNK1A1L | 0.63535814 |
| 80 | CSNK1E | 0.63322492 |
| 81 | CDK18 | 0.63272685 |
| 82 | CAMK1 | 0.63178984 |
| 83 | TAF1 | 0.63105874 |
| 84 | TSSK6 | 0.61428847 |
| 85 | PRKCE | 0.61031884 |
| 86 | CHEK2 | 0.59956899 |
| 87 | DYRK2 | 0.59927675 |
| 88 | ATM | 0.58908872 |
| 89 | DAPK3 | 0.58247319 |
| 90 | CDK1 | 0.58229116 |
| 91 | MAPK12 | 0.57088489 |
| 92 | CDK15 | 0.56227346 |
| 93 | CSNK1D | 0.56057869 |
| 94 | STK11 | 0.55534181 |
| 95 | PRKCH | 0.55396748 |
| 96 | CAMK2D | 0.55384898 |
| 97 | CHEK1 | 0.54323393 |
| 98 | MUSK | 0.53483802 |
| 99 | EIF2AK3 | 0.53274763 |
| 100 | INSRR | 0.52776263 |
| 101 | CSNK1G1 | 0.52444456 |
| 102 | CSNK1G3 | 0.51732082 |
| 103 | BUB1 | 0.51598489 |
| 104 | STK39 | 0.50054613 |
| 105 | TNK2 | 0.49892000 |
| 106 | DYRK1A | 0.49888438 |
| 107 | PRKDC | 0.49824130 |
| 108 | GSK3B | 0.49041266 |
| 109 | CDK14 | 0.47908887 |
| 110 | CDK11A | 0.47864821 |
| 111 | CAMK4 | 0.47538951 |
| 112 | CDK2 | 0.47276303 |
| 113 | NME1 | 0.46264320 |
| 114 | BRD4 | 0.44809380 |
| 115 | UHMK1 | 0.43830237 |
| 116 | CAMK1G | 0.40935843 |
| 117 | CSNK1G2 | 0.40522382 |
| 118 | YES1 | 0.40344117 |
| 119 | WNK1 | 0.38174158 |
| 120 | NTRK1 | 0.37226504 |
| 121 | CDC42BPA | 0.36038690 |
| 122 | MARK2 | 0.35676196 |
| 123 | ADRBK1 | 0.34052301 |
| 124 | GRK7 | 0.33840182 |
| 125 | CAMK2G | 0.33389096 |
| 126 | PKN1 | 0.32861279 |
| 127 | PRKD3 | 0.31932098 |
| 128 | PRKG1 | 0.31556358 |
| 129 | PDPK1 | 0.31348182 |
| 130 | MAP3K6 | 0.30979611 |
| 131 | RPS6KA3 | 0.28591745 |
| 132 | PDK1 | 0.28289312 |
| 133 | ROCK2 | 0.26857408 |
| 134 | CLK1 | 0.26590450 |
| 135 | PRKACA | 0.26263559 |
| 136 | MAP3K7 | 0.25911700 |
| 137 | KSR2 | 0.25887085 |
| 138 | MAPK10 | 0.25488925 |
| 139 | ARAF | 0.25337995 |
| 140 | CSNK1A1 | 0.25251687 |
| 141 | FYN | 0.24977043 |
| 142 | PRKCB | 0.23727211 |
| 143 | FGFR2 | 0.23376214 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.63553743 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.51219570 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 3.01092541 |
| 4 | Long-term potentiation_Homo sapiens_hsa04720 | 2.87800123 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.85651478 |
| 6 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.81063033 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.77797933 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.72254981 |
| 9 | Olfactory transduction_Homo sapiens_hsa04740 | 2.55330843 |
| 10 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.48733593 |
| 11 | GABAergic synapse_Homo sapiens_hsa04727 | 2.34995098 |
| 12 | Taste transduction_Homo sapiens_hsa04742 | 2.15216875 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 2.13182711 |
| 14 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.03249050 |
| 15 | Insulin secretion_Homo sapiens_hsa04911 | 2.01230369 |
| 16 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.95851409 |
| 17 | Long-term depression_Homo sapiens_hsa04730 | 1.83312876 |
| 18 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.81238448 |
| 19 | Renin secretion_Homo sapiens_hsa04924 | 1.80231541 |
| 20 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.74637987 |
| 21 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.61098856 |
| 22 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.57132842 |
| 23 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.56076203 |
| 24 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.55888075 |
| 25 | Homologous recombination_Homo sapiens_hsa03440 | 1.47095193 |
| 26 | Cocaine addiction_Homo sapiens_hsa05030 | 1.46995125 |
| 27 | Axon guidance_Homo sapiens_hsa04360 | 1.44285730 |
| 28 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.36653073 |
| 29 | Phototransduction_Homo sapiens_hsa04744 | 1.36471794 |
| 30 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.36130312 |
| 31 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.34354757 |
| 32 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.33131182 |
| 33 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.32387179 |
| 34 | Mismatch repair_Homo sapiens_hsa03430 | 1.30101868 |
| 35 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.30076180 |
| 36 | Circadian rhythm_Homo sapiens_hsa04710 | 1.29556851 |
| 37 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.24390863 |
| 38 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.23874218 |
| 39 | DNA replication_Homo sapiens_hsa03030 | 1.21473660 |
| 40 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.21384236 |
| 41 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.20852247 |
| 42 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.18923921 |
| 43 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.17574490 |
| 44 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.16596677 |
| 45 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.15567130 |
| 46 | Cell cycle_Homo sapiens_hsa04110 | 1.15515320 |
| 47 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.12003833 |
| 48 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.10587356 |
| 49 | RNA transport_Homo sapiens_hsa03013 | 1.10224287 |
| 50 | Basal transcription factors_Homo sapiens_hsa03022 | 1.06174626 |
| 51 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.05213303 |
| 52 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.04093141 |
| 53 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.03107230 |
| 54 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.01850461 |
| 55 | Gap junction_Homo sapiens_hsa04540 | 1.00859530 |
| 56 | RNA degradation_Homo sapiens_hsa03018 | 1.00429330 |
| 57 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.99076939 |
| 58 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.96070318 |
| 59 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.94155305 |
| 60 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.92720891 |
| 61 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.91323115 |
| 62 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.89028083 |
| 63 | Melanogenesis_Homo sapiens_hsa04916 | 0.87762372 |
| 64 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.83531676 |
| 65 | RNA polymerase_Homo sapiens_hsa03020 | 0.82674767 |
| 66 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.82259923 |
| 67 | Glioma_Homo sapiens_hsa05214 | 0.80173767 |
| 68 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.78539821 |
| 69 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.78007374 |
| 70 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.77534607 |
| 71 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.76101271 |
| 72 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.73802247 |
| 73 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.73452278 |
| 74 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.73101305 |
| 75 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.72400085 |
| 76 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.72012089 |
| 77 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.71688071 |
| 78 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.71443429 |
| 79 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.68414104 |
| 80 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.67808635 |
| 81 | Protein export_Homo sapiens_hsa03060 | 0.67706959 |
| 82 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.66847050 |
| 83 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.66729094 |
| 84 | Spliceosome_Homo sapiens_hsa03040 | 0.65891511 |
| 85 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.65147904 |
| 86 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.64411556 |
| 87 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.62890326 |
| 88 | Lysine degradation_Homo sapiens_hsa00310 | 0.61909179 |
| 89 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.61019131 |
| 90 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.59243333 |
| 91 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.58154645 |
| 92 | Purine metabolism_Homo sapiens_hsa00230 | 0.55794556 |
| 93 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.55174888 |
| 94 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.54639502 |
| 95 | Base excision repair_Homo sapiens_hsa03410 | 0.54147675 |
| 96 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.52776559 |
| 97 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.50302855 |
| 98 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.50233588 |
| 99 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.49994985 |
| 100 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.49059845 |
| 101 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.47178989 |
| 102 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.46510246 |
| 103 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.46030724 |
| 104 | Alzheimers disease_Homo sapiens_hsa05010 | 0.44150773 |
| 105 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.40585407 |
| 106 | Phagosome_Homo sapiens_hsa04145 | 0.40521270 |
| 107 | Huntingtons disease_Homo sapiens_hsa05016 | 0.39693070 |
| 108 | Melanoma_Homo sapiens_hsa05218 | 0.38508375 |
| 109 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.38362169 |
| 110 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.38355006 |
| 111 | Alcoholism_Homo sapiens_hsa05034 | 0.38195280 |
| 112 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.38031410 |
| 113 | Colorectal cancer_Homo sapiens_hsa05210 | 0.37229986 |
| 114 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.36011632 |
| 115 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.35751879 |
| 116 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.33525315 |
| 117 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.31325916 |
| 118 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.30948786 |
| 119 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.30697860 |
| 120 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.29917947 |
| 121 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.29138958 |
| 122 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.28192662 |
| 123 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.27360904 |
| 124 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.26563574 |
| 125 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.26275503 |
| 126 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.25669573 |
| 127 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.24685809 |
| 128 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.22882301 |
| 129 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.21776164 |
| 130 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.21665201 |
| 131 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.21099259 |
| 132 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.18140512 |

