R3HDM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.65994077
2locomotory exploration behavior (GO:0035641)4.50901649
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.47665059
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.44183681
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.14272367
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.03832335
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.00792454
8glutamate secretion (GO:0014047)3.98531932
9vocalization behavior (GO:0071625)3.79601679
10sodium ion export (GO:0071436)3.77383155
11synaptic vesicle exocytosis (GO:0016079)3.68831896
12cell communication by electrical coupling (GO:0010644)3.62754148
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.56489869
14layer formation in cerebral cortex (GO:0021819)3.54357388
15cellular potassium ion homeostasis (GO:0030007)3.43629016
16regulation of synaptic vesicle exocytosis (GO:2000300)3.40317848
17regulation of glutamate receptor signaling pathway (GO:1900449)3.37240623
18plasma membrane repair (GO:0001778)3.31225221
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26837985
20activation of protein kinase A activity (GO:0034199)3.26462483
21regulation of synapse structural plasticity (GO:0051823)3.20018407
22negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.17029303
23regulation of synaptic vesicle transport (GO:1902803)3.12975716
24cell communication involved in cardiac conduction (GO:0086065)3.10505956
25regulation of ARF protein signal transduction (GO:0032012)3.08276811
26negative regulation of potassium ion transmembrane transport (GO:1901380)3.06309438
27inositol phosphate catabolic process (GO:0071545)3.05759035
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.05758545
29neurotransmitter secretion (GO:0007269)3.04561568
30cardiac myofibril assembly (GO:0055003)3.03914112
31regulation of clathrin-mediated endocytosis (GO:2000369)2.99914199
32potassium ion import (GO:0010107)2.99038036
33exploration behavior (GO:0035640)2.95030566
34neurotransmitter-gated ion channel clustering (GO:0072578)2.94789870
35proline transport (GO:0015824)2.92968755
36regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.92483499
37regulation of neuronal synaptic plasticity (GO:0048168)2.91090644
38regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.89129604
39regulation of long-term neuronal synaptic plasticity (GO:0048169)2.86447821
40negative regulation of cAMP-mediated signaling (GO:0043951)2.85216223
41ionotropic glutamate receptor signaling pathway (GO:0035235)2.83227394
42regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.82633017
43protein localization to synapse (GO:0035418)2.82600344
44cytoskeletal anchoring at plasma membrane (GO:0007016)2.82133320
45regulation of membrane repolarization (GO:0060306)2.81623166
46adaptation of signaling pathway (GO:0023058)2.81457148
47dendritic spine morphogenesis (GO:0060997)2.81270623
48presynaptic membrane assembly (GO:0097105)2.78708073
49regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.77506826
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.77314907
51dicarboxylic acid biosynthetic process (GO:0043650)2.76223266
52negative regulation of protein oligomerization (GO:0032460)2.75218545
53macroautophagy (GO:0016236)2.75058916
54negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70972743
55positive regulation of glycolytic process (GO:0045821)2.70216450
56membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.69051757
57negative regulation of synaptic transmission, GABAergic (GO:0032229)2.68929779
58neuromuscular process controlling balance (GO:0050885)2.68258515
59regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.66901620
60synaptic vesicle endocytosis (GO:0048488)2.66660796
61G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66634512
62neuronal action potential propagation (GO:0019227)2.65753475
63gamma-aminobutyric acid transport (GO:0015812)2.65477122
64fucose catabolic process (GO:0019317)2.65170745
65L-fucose metabolic process (GO:0042354)2.65170745
66L-fucose catabolic process (GO:0042355)2.65170745
67positive regulation of synapse maturation (GO:0090129)2.64821871
68cardiac muscle contraction (GO:0060048)2.64511509
69cerebellar Purkinje cell differentiation (GO:0021702)2.63018433
70insulin secretion (GO:0030073)2.62858634
71retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62309449
72carnitine shuttle (GO:0006853)2.60420635
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.57142715
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.56533017
75regulation of excitatory postsynaptic membrane potential (GO:0060079)2.55621760
76regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.54699260
77long-term memory (GO:0007616)2.53952338
78regulation of calcium ion transmembrane transporter activity (GO:1901019)2.52353357
79regulation of calcium ion transmembrane transport (GO:1903169)2.52353357
80presynaptic membrane organization (GO:0097090)2.51833512
81positive regulation of sodium ion transport (GO:0010765)2.51645400
82membrane repolarization (GO:0086009)2.51236169
83cellular sodium ion homeostasis (GO:0006883)2.50663095
84regulation of dendritic spine morphogenesis (GO:0061001)2.50085062
85alanine transport (GO:0032328)2.49730495
86synaptic transmission, glutamatergic (GO:0035249)2.49648592
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.49548833
88inositol phosphate dephosphorylation (GO:0046855)2.49155406
89phosphorylated carbohydrate dephosphorylation (GO:0046838)2.49155406
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48184080
91establishment of nucleus localization (GO:0040023)2.47655446
92myofibril assembly (GO:0030239)2.47283113
93startle response (GO:0001964)2.45896793
94sarcoplasmic reticulum calcium ion transport (GO:0070296)2.45792417
95positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.45692130
96membrane depolarization during action potential (GO:0086010)2.44991394
97keratinocyte development (GO:0003334)2.43138459
98regulation of postsynaptic membrane potential (GO:0060078)2.43137245
99cardiac conduction (GO:0061337)2.42188468
100glutamate receptor signaling pathway (GO:0007215)2.41369094
101sarcomere organization (GO:0045214)2.40054206
102dendrite morphogenesis (GO:0048813)2.39495294
103chemosensory behavior (GO:0007635)2.39285125
104ventricular cardiac muscle cell action potential (GO:0086005)2.38881281
105polyol catabolic process (GO:0046174)2.38878102
106membrane repolarization during action potential (GO:0086011)2.38448510
107positive regulation of membrane potential (GO:0045838)2.38031657
108protein targeting to Golgi (GO:0000042)2.37992478
109regulation of autophagic vacuole assembly (GO:2000785)2.37704668
110regulation of synaptic plasticity (GO:0048167)2.37622791
111glycine transport (GO:0015816)2.37039904
112regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.36588399
113positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.36588399
114fatty acid transmembrane transport (GO:1902001)2.36542469
115positive regulation of potassium ion transmembrane transport (GO:1901381)2.36444678
116positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.36432960
117regulation of neurotransmitter uptake (GO:0051580)2.36177138
118cerebellar granule cell differentiation (GO:0021707)2.36065293
119neuronal action potential (GO:0019228)2.35363365
120negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35332461
121negative regulation of translation, ncRNA-mediated (GO:0040033)2.35332461
122regulation of translation, ncRNA-mediated (GO:0045974)2.35332461
123dentate gyrus development (GO:0021542)2.34692231
124potassium ion homeostasis (GO:0055075)2.34660591
125regulation of ion transmembrane transporter activity (GO:0032412)2.33838164
126cerebellar Purkinje cell layer development (GO:0021680)2.33719233
127detection of calcium ion (GO:0005513)2.32722931
128negative regulation of cell size (GO:0045792)2.32678904
129glycosphingolipid biosynthetic process (GO:0006688)2.31338138
130regulation of NFAT protein import into nucleus (GO:0051532)2.30225744
131neuromuscular synaptic transmission (GO:0007274)2.30192275
132regulation of sodium ion transmembrane transporter activity (GO:2000649)2.29006630
133serotonin metabolic process (GO:0042428)2.28724162
134establishment of protein localization to Golgi (GO:0072600)2.28617497
135behavioral response to nicotine (GO:0035095)2.28435450
136positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.27659495
137regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.27659495
138postsynaptic membrane organization (GO:0001941)2.25773593
139regulation of calcium ion-dependent exocytosis (GO:0017158)2.23245229
140primary amino compound metabolic process (GO:1901160)2.21348892
141reflex (GO:0060004)2.20211144
142cyclic nucleotide catabolic process (GO:0009214)2.18374966
143regulation of action potential (GO:0098900)2.18282869
144long-term synaptic potentiation (GO:0060291)2.16075522
145kidney morphogenesis (GO:0060993)2.15340180
146negative regulation of dendrite development (GO:2000171)2.14964541
147auditory receptor cell stereocilium organization (GO:0060088)2.14705840
148response to gravity (GO:0009629)2.14599547
149activated T cell proliferation (GO:0050798)2.14249479
150potassium ion transport (GO:0006813)2.13770588
151positive regulation of meiosis (GO:0045836)2.13730287
152cellular ketone body metabolic process (GO:0046950)2.13650061
153positive regulation of CREB transcription factor activity (GO:0032793)2.13389932
154regulation of vacuole organization (GO:0044088)2.13131836
155protein localization to Golgi apparatus (GO:0034067)2.12405944
156Golgi to endosome transport (GO:0006895)2.12184556
157positive regulation of granulocyte differentiation (GO:0030854)2.12182375
158long term synaptic depression (GO:0060292)2.11970218
159positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.11522941
160positive regulation of insulin secretion (GO:0032024)2.10501500
161negative regulation of protein autophosphorylation (GO:0031953)2.10481032
162positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.09597536
163nitric oxide mediated signal transduction (GO:0007263)2.08534063
164G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.08182066
165negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.07610347
166cAMP catabolic process (GO:0006198)2.07404496
167axoneme assembly (GO:0035082)2.06593661
168cellular potassium ion transport (GO:0071804)2.05420076
169potassium ion transmembrane transport (GO:0071805)2.05420076
170regulation of type B pancreatic cell apoptotic process (GO:2000674)2.04719834
171positive regulation of mRNA catabolic process (GO:0061014)2.04712911
172epithelial cell fate commitment (GO:0072148)2.04118022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.02668410
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.95733817
3DROSHA_22980978_ChIP-Seq_HELA_Human2.45774772
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.34743141
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.33090367
6ZNF274_21170338_ChIP-Seq_K562_Hela2.11099245
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08640951
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06333510
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00055504
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00055504
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99396546
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98431631
13MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93343009
14IGF1R_20145208_ChIP-Seq_DFB_Human1.86158187
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84735986
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83876960
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82390664
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81869764
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.81283862
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.80952275
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79913861
22KDM2B_26808549_Chip-Seq_K562_Human1.79243150
23VDR_22108803_ChIP-Seq_LS180_Human1.77577313
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76009533
25REST_21632747_ChIP-Seq_MESCs_Mouse1.74637518
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74551297
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72159557
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70084859
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69767485
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67260990
31ER_23166858_ChIP-Seq_MCF-7_Human1.67208853
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64588138
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64550958
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63849997
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.62763471
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61691377
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58735137
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.56986224
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.56880260
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56539514
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.56440761
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56418415
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.55385327
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.54705928
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54290281
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52272575
47GBX2_23144817_ChIP-Seq_PC3_Human1.52079373
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.51384837
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50545045
50BCAT_22108803_ChIP-Seq_LS180_Human1.50434896
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.47931666
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44697158
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44041436
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.43408004
55AR_25329375_ChIP-Seq_VCAP_Human1.42297193
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42290131
57KDM2B_26808549_Chip-Seq_DND41_Human1.41440542
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41344748
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39802798
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39521651
61* STAT3_23295773_ChIP-Seq_U87_Human1.39201325
62P300_19829295_ChIP-Seq_ESCs_Human1.36408807
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36289800
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35918939
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34199829
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33931165
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33315423
68LXR_22292898_ChIP-Seq_THP-1_Human1.31973009
69RXR_22158963_ChIP-Seq_LIVER_Mouse1.30392992
70TCF4_23295773_ChIP-Seq_U87_Human1.30297379
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.29616220
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.28981447
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.28142491
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.27356092
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26304857
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25700466
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25376144
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.25241247
79* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25050678
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22037610
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.20849788
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20569068
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20569068
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20129599
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.19824354
86TAF15_26573619_Chip-Seq_HEK293_Human1.18238028
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17788874
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17703790
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17424761
90FUS_26573619_Chip-Seq_HEK293_Human1.16975800
91CBP_20019798_ChIP-Seq_JUKART_Human1.16633775
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16633775
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16433736
94AR_19668381_ChIP-Seq_PC3_Human1.16402549
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16306168
96* SMAD3_21741376_ChIP-Seq_EPCs_Human1.16227105
97RUNX_20019798_ChIP-Seq_JUKART_Human1.15792831
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.15418728
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14904839
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14292202
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13368729
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12778526
103TBX20_22328084_ChIP-Seq_HEART_Mouse1.12743509
104TBX20_22080862_ChIP-Seq_HEART_Mouse1.12743509
105AHR_22903824_ChIP-Seq_MCF-7_Human1.12390415
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.12227659
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10908387
108AR_21572438_ChIP-Seq_LNCaP_Human1.10664030
109ZNF263_19887448_ChIP-Seq_K562_Human1.10495712
110* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10383203
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.10206465
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10012366
113NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09084315
114FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08920683
115TCF4_22108803_ChIP-Seq_LS180_Human1.08610014
116CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08310869
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07575875
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07502030
119RUNX2_22187159_ChIP-Seq_PCA_Human1.07292075
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06913566
121RING1B_27294783_Chip-Seq_ESCs_Mouse1.06781612
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06128672
123PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05932408
124* CREB1_26743006_Chip-Seq_LNCaP_Human1.05640354
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04553780
126CTCF_27219007_Chip-Seq_Bcells_Human1.03451676
127RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02325038
128* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02082631
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01626695
130SMAD3_21741376_ChIP-Seq_HESCs_Human1.01540732
131ARNT_22903824_ChIP-Seq_MCF-7_Human1.00717165
132TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00611435
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00465174
134BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00334443
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.99655296
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.99134563
137RXR_22108803_ChIP-Seq_LS180_Human0.98999373
138* FLI1_21867929_ChIP-Seq_TH2_Mouse0.98915557
139IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98914096
140CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98018557
141KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97664651
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97304402
143FLI1_27457419_Chip-Seq_LIVER_Mouse0.96772875
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95473073
145SMAD4_21799915_ChIP-Seq_A2780_Human0.94848536
146RNF2_27304074_Chip-Seq_NSC_Mouse0.94428425
147TCF7_22412390_ChIP-Seq_EML_Mouse0.94228235
148ISL1_27105846_Chip-Seq_CPCs_Mouse0.93696151
149SMC4_20622854_ChIP-Seq_HELA_Human0.93229116
150RING1B_27294783_Chip-Seq_NPCs_Mouse0.91940642
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91765786
152NANOG_19829295_ChIP-Seq_ESCs_Human0.91721761
153SOX2_19829295_ChIP-Seq_ESCs_Human0.91721761
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91704302
155TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91325159
156TET1_21490601_ChIP-Seq_MESCs_Mouse0.91040404
157TP53_16413492_ChIP-PET_HCT116_Human0.90576890
158* SMAD4_21741376_ChIP-Seq_EPCs_Human0.89657658
159KLF4_19829295_ChIP-Seq_ESCs_Human0.88568884
160LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87779487
161TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87602448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.42520534
2MP0002837_dystrophic_cardiac_calcinosis3.42025292
3MP0000751_myopathy3.07422884
4MP0003635_abnormal_synaptic_transmissio3.01408495
5MP0003787_abnormal_imprinting2.83555426
6MP0004270_analgesia2.79334395
7MP0009780_abnormal_chondrocyte_physiolo2.59986414
8MP0003646_muscle_fatigue2.59723097
9MP0003195_calcinosis2.38904313
10MP0005646_abnormal_pituitary_gland2.35590643
11MP0002063_abnormal_learning/memory/cond2.31932954
12MP0004130_abnormal_muscle_cell2.26677749
13MP0002876_abnormal_thyroid_physiology2.26135327
14MP0002909_abnormal_adrenal_gland2.25264668
15MP0004084_abnormal_cardiac_muscle2.14709082
16MP0008961_abnormal_basal_metabolism2.10748108
17MP0004215_abnormal_myocardial_fiber2.09989497
18MP0009745_abnormal_behavioral_response2.09498268
19MP0002064_seizures2.07843977
20MP0003880_abnormal_central_pattern1.98266062
21MP0009046_muscle_twitch1.92592532
22MP0004036_abnormal_muscle_relaxation1.90976263
23MP0004858_abnormal_nervous_system1.87520250
24MP0010386_abnormal_urinary_bladder1.86806476
25MP0003705_abnormal_hypodermis_morpholog1.81349312
26MP0002822_catalepsy1.78159020
27MP0001984_abnormal_olfaction1.77774939
28MP0003329_amyloid_beta_deposits1.77222923
29MP0004087_abnormal_muscle_fiber1.75436999
30MP0004510_myositis1.75426124
31MP0004145_abnormal_muscle_electrophysio1.74438789
32MP0002572_abnormal_emotion/affect_behav1.72845507
33MP0005551_abnormal_eye_electrophysiolog1.71993287
34MP0002638_abnormal_pupillary_reflex1.69915709
35MP0004233_abnormal_muscle_weight1.69782960
36MP0005645_abnormal_hypothalamus_physiol1.60797955
37MP0000749_muscle_degeneration1.59696117
38MP0008569_lethality_at_weaning1.58439795
39MP0005330_cardiomyopathy1.54939522
40MP0008872_abnormal_physiological_respon1.53229350
41MP0001486_abnormal_startle_reflex1.45293413
42MP0005620_abnormal_muscle_contractility1.44954324
43MP0000569_abnormal_digit_pigmentation1.44289540
44MP0004085_abnormal_heartbeat1.43740260
45MP0002269_muscular_atrophy1.41708150
46MP0001501_abnormal_sleep_pattern1.40778763
47MP0003137_abnormal_impulse_conducting1.40331721
48MP0003879_abnormal_hair_cell1.38929924
49MP0002734_abnormal_mechanical_nocicepti1.36924241
50MP0004885_abnormal_endolymph1.36418546
51MP0002272_abnormal_nervous_system1.36188836
52MP0000747_muscle_weakness1.36176781
53MP0002693_abnormal_pancreas_physiology1.36175890
54MP0001944_abnormal_pancreas_morphology1.35164567
55MP0002972_abnormal_cardiac_muscle1.33386221
56MP0004381_abnormal_hair_follicle1.33362744
57MP0005075_abnormal_melanosome_morpholog1.33282335
58MP0004484_altered_response_of1.31303990
59MP0001905_abnormal_dopamine_level1.31183947
60MP0006072_abnormal_retinal_apoptosis1.30149849
61MP0008877_abnormal_DNA_methylation1.29113573
62MP0002106_abnormal_muscle_physiology1.29104147
63MP0004185_abnormal_adipocyte_glucose1.29024183
64MP0001440_abnormal_grooming_behavior1.28746157
65MP0001968_abnormal_touch/_nociception1.28278836
66MP0005423_abnormal_somatic_nervous1.27918643
67MP0005365_abnormal_bile_salt1.26723270
68MP0005379_endocrine/exocrine_gland_phen1.26125075
69MP0001986_abnormal_taste_sensitivity1.25394699
70MP0005085_abnormal_gallbladder_physiolo1.24472024
71MP0001485_abnormal_pinna_reflex1.23869004
72MP0002735_abnormal_chemical_nociception1.23674977
73MP0004811_abnormal_neuron_physiology1.23460260
74MP0003633_abnormal_nervous_system1.23458300
75MP0010630_abnormal_cardiac_muscle1.22083621
76MP0005174_abnormal_tail_pigmentation1.21487096
77MP0000759_abnormal_skeletal_muscle1.20566906
78MP0002928_abnormal_bile_duct1.19555604
79MP0000631_abnormal_neuroendocrine_gland1.18518553
80MP0003075_altered_response_to1.18338643
81MP0005360_urolithiasis1.17486748
82MP0002102_abnormal_ear_morphology1.14328161
83MP0006138_congestive_heart_failure1.14196983
84MP0005253_abnormal_eye_physiology1.14005580
85MP0004043_abnormal_pH_regulation1.13907074
86MP0003252_abnormal_bile_duct1.12009290
87MP0002139_abnormal_hepatobiliary_system1.11895750
88MP0004924_abnormal_behavior1.11128847
89MP0005386_behavior/neurological_phenoty1.11128847
90MP0000750_abnormal_muscle_regeneration1.10539091
91MP0000427_abnormal_hair_cycle1.09155522
92MP0005187_abnormal_penis_morphology1.07713171
93MP0008874_decreased_physiological_sensi1.07622391
94MP0005369_muscle_phenotype1.07547390
95MP0008775_abnormal_heart_ventricle1.06894817
96MP0002009_preneoplasia1.06870890
97MP0002067_abnormal_sensory_capabilities1.06718922
98MP0005623_abnormal_meninges_morphology1.04769326
99MP0005666_abnormal_adipose_tissue1.04437756
100MP0010329_abnormal_lipoprotein_level1.03356999
101MP0005385_cardiovascular_system_phenoty1.02542036
102MP0001544_abnormal_cardiovascular_syste1.02542036
103MP0002736_abnormal_nociception_after1.01623223
104MP0000516_abnormal_urinary_system1.01146256
105MP0005367_renal/urinary_system_phenotyp1.01146256
106MP0003045_fibrosis1.00775472
107MP0003724_increased_susceptibility_to1.00731811
108MP0001756_abnormal_urination1.00628212
109MP0003283_abnormal_digestive_organ1.00130113
110MP0002733_abnormal_thermal_nociception0.98774955
111MP0000538_abnormal_urinary_bladder0.98557105
112MP0005220_abnormal_exocrine_pancreas0.98175788
113MP0003172_abnormal_lysosome_physiology0.97539060
114MP0002090_abnormal_vision0.97516701
115MP0005535_abnormal_body_temperature0.97467276
116MP0005167_abnormal_blood-brain_barrier0.97248125
117MP0002166_altered_tumor_susceptibility0.96959399
118MP0004142_abnormal_muscle_tone0.96074664
119MP0000015_abnormal_ear_pigmentation0.95900654
120MP0002234_abnormal_pharynx_morphology0.94471821
121MP0002066_abnormal_motor_capabilities/c0.93910556
122MP0005375_adipose_tissue_phenotype0.92397678
123MP0003690_abnormal_glial_cell0.91435040
124MP0002163_abnormal_gland_morphology0.91404577
125MP0002138_abnormal_hepatobiliary_system0.91306875
126MP0001970_abnormal_pain_threshold0.91226100
127MP0001765_abnormal_ion_homeostasis0.90739579
128MP0000604_amyloidosis0.90703537
129MP0000955_abnormal_spinal_cord0.89212910
130MP0002229_neurodegeneration0.88835670
131MP0006276_abnormal_autonomic_nervous0.88723214
132MP0003631_nervous_system_phenotype0.87676998
133MP0001502_abnormal_circadian_rhythm0.87543330
134MP0002557_abnormal_social/conspecific_i0.85650424
135MP0002108_abnormal_muscle_morphology0.84006560
136MP0000230_abnormal_systemic_arterial0.83827053
137MP0010234_abnormal_vibrissa_follicle0.83543757
138MP0002882_abnormal_neuron_morphology0.82545453
139MP0005448_abnormal_energy_balance0.82462811
140MP0000003_abnormal_adipose_tissue0.82055302
141MP0005076_abnormal_cell_differentiation0.81587169
142MP0003303_peritoneal_inflammation0.81166301
143MP0000013_abnormal_adipose_tissue0.79722184
144MP0002078_abnormal_glucose_homeostasis0.79239937
145MP0002118_abnormal_lipid_homeostasis0.76904218
146MP0002184_abnormal_innervation0.75805396
147MP0003953_abnormal_hormone_level0.73718639
148MP0000639_abnormal_adrenal_gland0.73332908
149MP0003763_abnormal_thymus_physiology0.73322632
150MP0002277_abnormal_respiratory_mucosa0.72501741
151MP0008995_early_reproductive_senescence0.72092451

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)4.02981290
2Focal motor seizures (HP:0011153)3.90984058
3Sudden death (HP:0001699)3.85042533
4Bundle branch block (HP:0011710)3.63597291
5Dysmetric saccades (HP:0000641)3.62000272
6Exercise-induced myalgia (HP:0003738)3.59242322
7Visual hallucinations (HP:0002367)3.55761486
8Myokymia (HP:0002411)3.54444542
9Focal seizures (HP:0007359)3.44310114
10Hemiparesis (HP:0001269)3.29204010
11Ventricular fibrillation (HP:0001663)3.27131207
12Abnormality of the lower motor neuron (HP:0002366)3.08602144
13Pancreatic cysts (HP:0001737)3.03217470
14Exercise-induced muscle cramps (HP:0003710)2.84971750
15Abnormality of the renal cortex (HP:0011035)2.84464508
16Thyroiditis (HP:0100646)2.82821349
17Syncope (HP:0001279)2.82537002
18Absent speech (HP:0001344)2.81118402
19Impaired social interactions (HP:0000735)2.80217749
20Abnormal social behavior (HP:0012433)2.80217749
21Genetic anticipation (HP:0003743)2.80210191
22Action tremor (HP:0002345)2.79547210
23Epileptic encephalopathy (HP:0200134)2.74454659
24Hyporeflexia of lower limbs (HP:0002600)2.73705444
25Atrial fibrillation (HP:0005110)2.72353044
26Congenital stationary night blindness (HP:0007642)2.65809174
27Primary atrial arrhythmia (HP:0001692)2.64410693
28Poor eye contact (HP:0000817)2.64251024
29Difficulty running (HP:0009046)2.64058724
30Pancreatic fibrosis (HP:0100732)2.64044767
31Dysdiadochokinesis (HP:0002075)2.63103289
32Urinary bladder sphincter dysfunction (HP:0002839)2.61613635
33Heart block (HP:0012722)2.60772663
34Abnormal rod and cone electroretinograms (HP:0008323)2.60226839
35Nephronophthisis (HP:0000090)2.58637920
36Postural instability (HP:0002172)2.56951240
37Atrioventricular block (HP:0001678)2.54946990
38Generalized tonic-clonic seizures (HP:0002069)2.51188621
39Type II lissencephaly (HP:0007260)2.50210548
40Hematochezia (HP:0002573)2.50073390
41Depression (HP:0000716)2.47567529
42Calf muscle hypertrophy (HP:0008981)2.45774588
43Widely spaced teeth (HP:0000687)2.45197667
44Large for gestational age (HP:0001520)2.44476143
45Absence seizures (HP:0002121)2.44125396
46Ventricular arrhythmia (HP:0004308)2.43577760
47Prolonged QT interval (HP:0001657)2.43150284
48Supraventricular tachycardia (HP:0004755)2.41968834
49Abnormal atrioventricular conduction (HP:0005150)2.40830176
50Impaired vibration sensation in the lower limbs (HP:0002166)2.39834349
51Ventricular tachycardia (HP:0004756)2.39342695
52Myoglobinuria (HP:0002913)2.38390358
53Renal cortical cysts (HP:0000803)2.38015307
54Supraventricular arrhythmia (HP:0005115)2.37360686
55True hermaphroditism (HP:0010459)2.37045762
56Abnormality of the renal medulla (HP:0100957)2.36534282
57Asymmetric septal hypertrophy (HP:0001670)2.36295701
58Macroorchidism (HP:0000053)2.35728121
59Aqueductal stenosis (HP:0002410)2.34743920
60Atonic seizures (HP:0010819)2.34472115
61Abnormality of the calf musculature (HP:0001430)2.32803286
62Attenuation of retinal blood vessels (HP:0007843)2.32494589
63Progressive cerebellar ataxia (HP:0002073)2.32208643
64Muscle hypertrophy of the lower extremities (HP:0008968)2.31278762
65Hemiplegia (HP:0002301)2.30058926
66Neoplasm of the adrenal cortex (HP:0100641)2.29798583
67Ketoacidosis (HP:0001993)2.28851388
68Cystic liver disease (HP:0006706)2.28839292
69Supranuclear gaze palsy (HP:0000605)2.26516985
70Muscle fiber splitting (HP:0003555)2.23451007
71Abnormal drinking behavior (HP:0030082)2.21441536
72Polydipsia (HP:0001959)2.21441536
73Epileptiform EEG discharges (HP:0011182)2.21281302
74Right ventricular cardiomyopathy (HP:0011663)2.19390070
75Congenital sensorineural hearing impairment (HP:0008527)2.18605917
76Febrile seizures (HP:0002373)2.18179894
77Subaortic stenosis (HP:0001682)2.16336544
78Abnormality of the left ventricular outflow tract (HP:0011103)2.16336544
79Lower limb amyotrophy (HP:0007210)2.14650500
80Increased variability in muscle fiber diameter (HP:0003557)2.14589524
81Abnormal EKG (HP:0003115)2.14309322
82EEG with generalized epileptiform discharges (HP:0011198)2.11720734
83Myotonia (HP:0002486)2.11581410
84Status epilepticus (HP:0002133)2.10950630
85Dialeptic seizures (HP:0011146)2.10895940
86EMG: myopathic abnormalities (HP:0003458)2.09164670
87Hyperventilation (HP:0002883)2.06669517
88Clumsiness (HP:0002312)2.06293648
89Broad-based gait (HP:0002136)2.04681431
90Increased corneal curvature (HP:0100692)2.04540983
91Keratoconus (HP:0000563)2.04540983
92Papilledema (HP:0001085)2.04136067
93Lymphangioma (HP:0100764)2.02172000
94Generalized hypopigmentation of hair (HP:0011358)2.02022169
95Hypsarrhythmia (HP:0002521)2.01368762
96Rapidly progressive (HP:0003678)2.01271940
97Dysmetria (HP:0001310)2.00494034
98Decreased central vision (HP:0007663)2.00464446
99Ankle clonus (HP:0011448)1.99865555
100Urinary urgency (HP:0000012)1.99140040
101Abnormality of the Achilles tendon (HP:0005109)1.98449585
102Stomatitis (HP:0010280)1.97363249
103Diplopia (HP:0000651)1.96986244
104Abnormality of binocular vision (HP:0011514)1.96986244
105Resting tremor (HP:0002322)1.96401057
106Molar tooth sign on MRI (HP:0002419)1.95999302
107Abnormality of midbrain morphology (HP:0002418)1.95999302
108Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95878138
109Obstructive sleep apnea (HP:0002870)1.95659280
110Deep venous thrombosis (HP:0002625)1.95575622
111Increased connective tissue (HP:0009025)1.95154195
112Gaze-evoked nystagmus (HP:0000640)1.95117908
113Central scotoma (HP:0000603)1.95095413
114Fair hair (HP:0002286)1.94848265
115Tongue fasciculations (HP:0001308)1.94761235
116Furrowed tongue (HP:0000221)1.94487220
117Torticollis (HP:0000473)1.94003519
118Conjunctival hamartoma (HP:0100780)1.93951970
119Hamartoma of the eye (HP:0010568)1.93788827
120Achilles tendon contracture (HP:0001771)1.93732867
121Ketosis (HP:0001946)1.92762994
122EMG: neuropathic changes (HP:0003445)1.92679076
123Hyperglycemia (HP:0003074)1.92642039
124Cerebral inclusion bodies (HP:0100314)1.92292752
125Agitation (HP:0000713)1.91694905
126Impaired smooth pursuit (HP:0007772)1.90551478
127Anxiety (HP:0000739)1.89687070
128Global brain atrophy (HP:0002283)1.88195747
129Gout (HP:0001997)1.87373440
130Increased circulating renin level (HP:0000848)1.87144890
131Intellectual disability, progressive (HP:0006887)1.84329982
132Distal upper limb amyotrophy (HP:0007149)1.84062804
133Upper limb amyotrophy (HP:0009129)1.84062804
134Difficulty climbing stairs (HP:0003551)1.83504529
135Impaired vibratory sensation (HP:0002495)1.82661230
136Hypoglycemic coma (HP:0001325)1.82463115
137Insomnia (HP:0100785)1.82251855
138Hypoplasia of the odontoid process (HP:0003311)1.82165042
139Hypomagnesemia (HP:0002917)1.81430238
140Abolished electroretinogram (ERG) (HP:0000550)1.81422143
141Hyperacusis (HP:0010780)1.80685513
142Tubular atrophy (HP:0000092)1.80496033
143Cerebral aneurysm (HP:0004944)1.80463878
144Tented upper lip vermilion (HP:0010804)1.80362911
145Neoplasm of the heart (HP:0100544)1.80060217
146Testicular neoplasm (HP:0010788)1.79647170
147Abnormality of skeletal muscle fiber size (HP:0012084)1.79338589
148Medial flaring of the eyebrow (HP:0010747)1.79196466
149Muscle fibrillation (HP:0010546)1.78709658
150Pachygyria (HP:0001302)1.78503609
151Stomach cancer (HP:0012126)1.78202164
152Excessive salivation (HP:0003781)1.74751946
153Drooling (HP:0002307)1.74751946
154Intention tremor (HP:0002080)1.74700678
155Termporal pattern (HP:0011008)1.74644134
156Insidious onset (HP:0003587)1.74644134
157Increased CSF protein (HP:0002922)1.73918636
158Enlarged penis (HP:0000040)1.73157990
159Protruding tongue (HP:0010808)1.72964730
160Blue irides (HP:0000635)1.72028484
161Hypoplastic ischia (HP:0003175)1.71446647
162Intestinal atresia (HP:0011100)1.71110767
163Late onset (HP:0003584)1.70164301
164Hyperinsulinemic hypoglycemia (HP:0000825)1.68387049
165Decreased circulating renin level (HP:0003351)1.66090874
166Abnormality of the columella (HP:0009929)1.65184624
167Inability to walk (HP:0002540)1.64675277
168Hypoplastic iliac wings (HP:0002866)1.64553862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.31477815
2TRIB32.96133587
3MAP3K92.91658330
4EPHA42.80776189
5DAPK22.62544008
6PRKD32.44596345
7NTRK32.33014884
8PAK62.30164467
9MAP3K42.29508675
10BMPR1B2.01608654
11TAOK11.96071466
12RIPK11.93864589
13TNK21.89254752
14MAP4K21.86181346
15KSR21.85000915
16CAMKK11.82589968
17MAP2K41.77993877
18STK381.74489830
19PKN21.73660810
20MAPK131.73329934
21CASK1.70227690
22DMPK1.66277646
23TTN1.65587013
24GRK11.64345036
25TYRO31.63015636
26PHKG21.62647841
27PHKG11.62647841
28TAOK31.62334536
29CAMK1G1.57225115
30ADRBK21.55914998
31SIK21.55721440
32MINK11.46548436
33ICK1.45232887
34TXK1.40364161
35MARK11.40102608
36TNIK1.36607685
37PDGFRA1.36308136
38NLK1.35224026
39NEK11.33779202
40LMTK21.30754890
41MAP3K71.29364682
42HIPK21.25534107
43NTRK21.25036832
44PRKCH1.22565873
45NTRK11.21499472
46SGK31.19460743
47PINK11.17126594
48LATS21.16570777
49MARK31.15756552
50RIPK41.13892823
51SIK11.12823340
52DAPK11.12301596
53OXSR11.11103942
54CDK121.10605003
55FGFR31.10265882
56AKT31.09987370
57RET1.09887226
58WNK31.07186730
59CAMK1D1.07182450
60STK111.04485646
61MAP2K71.03792294
62ERN11.02959264
63CDK51.02631185
64ALK1.00192601
65PRKCE0.97672646
66MAP2K60.97208824
67PAK30.95862834
68CAMK40.95828332
69KSR10.95547484
70CDC42BPA0.94415157
71MARK20.93754270
72TRPM70.93579409
73CAMK10.91935521
74MAP3K20.91182422
75DDR20.84416201
76PDPK10.83219203
77MUSK0.81411865
78PTK2B0.80693706
79SGK20.80224446
80LATS10.80044798
81PDK10.78979473
82ERBB30.78590183
83NUAK10.77013450
84WNK10.76430891
85GRK60.76323001
86PDK40.75217162
87PDK30.75217162
88MAP4K10.72833750
89STK390.72180105
90SGK4940.72086663
91SGK2230.72086663
92MAPK120.71719647
93MAP3K10.71352485
94SGK10.71080764
95CDK30.71022512
96ITK0.70779997
97PRPF4B0.70310130
98SIK30.67635742
99PRKCQ0.67387691
100EEF2K0.67358893
101MAPK70.67214572
102MAP3K100.66550977
103GRK50.66456137
104MAP3K60.66253699
105PRKAA10.66131479
106PRKD10.66081950
107PTK60.65969159
108BMX0.65613974
109UHMK10.64064422
110PRKD20.62176749
111PRKCG0.62141703
112WNK40.61725078
113PLK20.59578341
114CAMKK20.58862631
115CAMK2A0.58605114
116PTK20.58461909
117RPS6KA30.58067652
118MAP3K130.52970229
119INSRR0.52106342
120MTOR0.51901607
121CSNK1A1L0.50912778
122IRAK10.49960837
123OBSCN0.49324580
124PDGFRB0.48491013
125FES0.47769769
126MAPKAPK30.46831456
127ACVR1B0.46584810
128PRKCZ0.45981335
129CHUK0.45762150
130MAPK150.45557535
131DAPK30.44989553
132ROCK10.44987412
133CDK190.44542894
134CSNK1G20.44404712
135FGFR20.43695503
136PIK3CA0.42665748
137SYK0.42258260
138FER0.42249211
139CSNK1G30.41720002
140IKBKB0.41049845
141MAPK100.40867560
142CDK150.39701845
143PRKG10.39038137
144PRKCI0.38223543
145JAK10.37370651
146PRKAA20.36822043
147CDK180.36790384

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.83918914
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.78507115
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47922812
4Synaptic vesicle cycle_Homo sapiens_hsa047211.93218086
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80853441
6Circadian entrainment_Homo sapiens_hsa047131.78129731
7Long-term potentiation_Homo sapiens_hsa047201.77636064
8Nicotine addiction_Homo sapiens_hsa050331.71813179
9Insulin secretion_Homo sapiens_hsa049111.68661103
10Olfactory transduction_Homo sapiens_hsa047401.67927999
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67081696
12GABAergic synapse_Homo sapiens_hsa047271.63121305
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61800817
14Glutamatergic synapse_Homo sapiens_hsa047241.61752473
15Type II diabetes mellitus_Homo sapiens_hsa049301.57019420
16Arginine biosynthesis_Homo sapiens_hsa002201.56996407
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56328753
18Amphetamine addiction_Homo sapiens_hsa050311.52569562
19Gastric acid secretion_Homo sapiens_hsa049711.51191844
20Salivary secretion_Homo sapiens_hsa049701.50753239
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50155199
22Dilated cardiomyopathy_Homo sapiens_hsa054141.49600487
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45739198
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45360699
25Morphine addiction_Homo sapiens_hsa050321.44422776
26Oxytocin signaling pathway_Homo sapiens_hsa049211.35026999
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33911428
28ABC transporters_Homo sapiens_hsa020101.33076372
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31976975
30Dopaminergic synapse_Homo sapiens_hsa047281.31358161
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31283908
32Cholinergic synapse_Homo sapiens_hsa047251.27606746
33Renin secretion_Homo sapiens_hsa049241.26512168
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25920690
35Regulation of autophagy_Homo sapiens_hsa041401.21808636
36Bile secretion_Homo sapiens_hsa049761.18517731
37GnRH signaling pathway_Homo sapiens_hsa049121.14420173
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12946628
39Linoleic acid metabolism_Homo sapiens_hsa005911.12598027
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07180787
41Collecting duct acid secretion_Homo sapiens_hsa049661.06910812
42Calcium signaling pathway_Homo sapiens_hsa040201.06604197
43Glioma_Homo sapiens_hsa052141.06257558
44cAMP signaling pathway_Homo sapiens_hsa040241.05596841
45mTOR signaling pathway_Homo sapiens_hsa041501.05438835
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03674226
47Cocaine addiction_Homo sapiens_hsa050301.02715914
48Glucagon signaling pathway_Homo sapiens_hsa049221.02704788
49Estrogen signaling pathway_Homo sapiens_hsa049151.02390021
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01002388
51Cardiac muscle contraction_Homo sapiens_hsa042600.99715616
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99099474
53Ether lipid metabolism_Homo sapiens_hsa005650.98247340
54Dorso-ventral axis formation_Homo sapiens_hsa043200.98031550
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95723580
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94295112
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92927970
58T cell receptor signaling pathway_Homo sapiens_hsa046600.92349222
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92277821
60Insulin resistance_Homo sapiens_hsa049310.92048750
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90489987
62Fatty acid degradation_Homo sapiens_hsa000710.90419632
63Long-term depression_Homo sapiens_hsa047300.89496689
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89266061
65Gap junction_Homo sapiens_hsa045400.88780165
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87879847
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87500153
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86952432
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86819182
70Type I diabetes mellitus_Homo sapiens_hsa049400.86058785
71Insulin signaling pathway_Homo sapiens_hsa049100.85690109
72Taste transduction_Homo sapiens_hsa047420.85569410
73Lysine degradation_Homo sapiens_hsa003100.83938099
74Butanoate metabolism_Homo sapiens_hsa006500.81873981
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80274233
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.80000013
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79403253
78Ovarian steroidogenesis_Homo sapiens_hsa049130.78519844
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77882132
80Fatty acid metabolism_Homo sapiens_hsa012120.76066378
81VEGF signaling pathway_Homo sapiens_hsa043700.75249109
82ErbB signaling pathway_Homo sapiens_hsa040120.75138189
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.73840292
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.72397509
85Melanogenesis_Homo sapiens_hsa049160.69849939
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69107169
87Pancreatic secretion_Homo sapiens_hsa049720.68299492
88PPAR signaling pathway_Homo sapiens_hsa033200.68158035
89AMPK signaling pathway_Homo sapiens_hsa041520.67376403
90Primary immunodeficiency_Homo sapiens_hsa053400.67083997
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.67034242
92Circadian rhythm_Homo sapiens_hsa047100.65811368
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.64227497
94Thyroid hormone synthesis_Homo sapiens_hsa049180.63299621
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.62620592
96Fatty acid biosynthesis_Homo sapiens_hsa000610.62540812
97Mineral absorption_Homo sapiens_hsa049780.62062381
98Serotonergic synapse_Homo sapiens_hsa047260.59365272
99Propanoate metabolism_Homo sapiens_hsa006400.58528370
100FoxO signaling pathway_Homo sapiens_hsa040680.58180327
101MAPK signaling pathway_Homo sapiens_hsa040100.56977717
102Choline metabolism in cancer_Homo sapiens_hsa052310.56903129
103Ras signaling pathway_Homo sapiens_hsa040140.56791350
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56573811
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55895410
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.55689835
107Non-small cell lung cancer_Homo sapiens_hsa052230.54865431
108Endometrial cancer_Homo sapiens_hsa052130.54715073
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54546524
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54137691
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53914297
112Renal cell carcinoma_Homo sapiens_hsa052110.53235876
113Axon guidance_Homo sapiens_hsa043600.52463522
114Carbon metabolism_Homo sapiens_hsa012000.50676752
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48228506
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.47948080
117Tryptophan metabolism_Homo sapiens_hsa003800.47414059
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47018765
119Rap1 signaling pathway_Homo sapiens_hsa040150.46880557
120Arachidonic acid metabolism_Homo sapiens_hsa005900.43776967
121Platelet activation_Homo sapiens_hsa046110.43275360
122Peroxisome_Homo sapiens_hsa041460.43018728
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42885143
124Phototransduction_Homo sapiens_hsa047440.42880672
125Caffeine metabolism_Homo sapiens_hsa002320.42398788
126Focal adhesion_Homo sapiens_hsa045100.42072881
127Chemical carcinogenesis_Homo sapiens_hsa052040.42051816
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41798969
129Starch and sucrose metabolism_Homo sapiens_hsa005000.41688508
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.41539526
131Histidine metabolism_Homo sapiens_hsa003400.41506986
132Prion diseases_Homo sapiens_hsa050200.41362225
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41334569
134beta-Alanine metabolism_Homo sapiens_hsa004100.41305107
135Proteoglycans in cancer_Homo sapiens_hsa052050.40885929
136Amoebiasis_Homo sapiens_hsa051460.40194032
137Inositol phosphate metabolism_Homo sapiens_hsa005620.40128127
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37117288
139Sphingolipid metabolism_Homo sapiens_hsa006000.35495582

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