ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	diol metabolic process (GO:0034311)	9.66653311
2	sphingoid metabolic process (GO:0046519)	8.44183374
3	DNA deamination (GO:0045006)	7.53200474
4	DNA methylation involved in gamete generation (GO:0043046)	7.42611606
5	protein-chromophore linkage (GO:0018298)	6.79657531
6	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	6.50908733
7	regulation of meiosis I (GO:0060631)	6.22002728
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.64573310
9	cell migration involved in heart development (GO:0060973)	5.53305085
10	lipopolysaccharide biosynthetic process (GO:0009103)	5.49542107
11	piRNA metabolic process (GO:0034587)	5.42433537
12	cellular anion homeostasis (GO:0030002)	5.40952598
13	somite rostral/caudal axis specification (GO:0032525)	5.09167211
14	sulfate transmembrane transport (GO:1902358)	5.08656924
15	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	5.05258641
16	regulation of mesoderm development (GO:2000380)	4.99677434
17	heart field specification (GO:0003128)	4.92864226
18	secondary heart field specification (GO:0003139)	4.92864226
19	regulation of protein glycosylation (GO:0060049)	4.82799574
20	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.80289087
21	lipopolysaccharide metabolic process (GO:0008653)	4.65695917
22	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	4.49285758
23	heme transport (GO:0015886)	4.36913025
24	regulation of pigment cell differentiation (GO:0050932)	4.32180541
25	negative regulation of glycoprotein biosynthetic process (GO:0010561)	4.30898218
26	sulfate transport (GO:0008272)	4.30443826
27	positive regulation of developmental pigmentation (GO:0048087)	4.29433243
28	positive regulation of meiosis (GO:0045836)	4.24605626
29	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	4.19283717
30	L-phenylalanine catabolic process (GO:0006559)	4.08704488
31	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.08704488
32	negative regulation of cell fate commitment (GO:0010454)	4.06786748
33	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.03131941
34	positive regulation of meiotic cell cycle (GO:0051446)	4.00108752
35	cytidine metabolic process (GO:0046087)	3.97160644
36	cytidine catabolic process (GO:0006216)	3.97160644
37	cytidine deamination (GO:0009972)	3.97160644
38	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.95301798
39	positive regulation of cell fate commitment (GO:0010455)	3.93697385
40	negative regulation of cell fate specification (GO:0009996)	3.92499009
41	serotonin receptor signaling pathway (GO:0007210)	3.88684541
42	behavioral response to nicotine (GO:0035095)	3.88175069
43	tyrosine metabolic process (GO:0006570)	3.86223689
44	paraxial mesoderm development (GO:0048339)	3.83289029
45	positive regulation of fibroblast migration (GO:0010763)	3.81599652
46	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.79039764
47	toxin metabolic process (GO:0009404)	3.75311669
48	cardiac ventricle formation (GO:0003211)	3.71124309
49	negative regulation of stem cell proliferation (GO:2000647)	3.69947763
50	adaptation of signaling pathway (GO:0023058)	3.67623339
51	SMAD protein complex assembly (GO:0007183)	3.65181433
52	negative regulation of cell cycle G2/M phase transition (GO:1902750)	3.63158179
53	necroptotic process (GO:0070266)	3.52524227
54	tachykinin receptor signaling pathway (GO:0007217)	3.48129620
55	L-phenylalanine metabolic process (GO:0006558)	3.45490310
56	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.45490310
57	positive regulation of defense response to virus by host (GO:0002230)	3.41946157
58	positive regulation of endothelial cell apoptotic process (GO:2000353)	3.40378821
59	aromatic amino acid family catabolic process (GO:0009074)	3.39217724
60	negative regulation of systemic arterial blood pressure (GO:0003085)	3.37208825
61	cardiac chamber formation (GO:0003207)	3.36376426
62	ribonucleoprotein complex disassembly (GO:0032988)	3.35032645
63	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.33356757
64	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.33356757
65	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.31649425
66	cell migration involved in gastrulation (GO:0042074)	3.28371498
67	regulation of odontogenesis (GO:0042481)	3.22909572
68	intracellular pH reduction (GO:0051452)	3.21422741
69	endothelial cell differentiation (GO:0045446)	3.19113148
70	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.18674535
71	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.18256608
72	indolalkylamine metabolic process (GO:0006586)	3.18225474
73	specification of organ identity (GO:0010092)	3.11718049
74	centriole replication (GO:0007099)	3.05560631
75	aromatic amino acid family metabolic process (GO:0009072)	3.05214176
76	negative regulation of glycoprotein metabolic process (GO:1903019)	3.03524177
77	sleep (GO:0030431)	3.03483255
78	negative regulation of telomere maintenance (GO:0032205)	3.00117691
79	regulation of gonadotropin secretion (GO:0032276)	2.99936170
80	signal transduction involved in regulation of gene expression (GO:0023019)	2.99459578
81	glycerol metabolic process (GO:0006071)	2.99381007
82	primary amino compound metabolic process (GO:1901160)	2.97725707
83	regulation of SMAD protein import into nucleus (GO:0060390)	2.97535320
84	iron coordination entity transport (GO:1901678)	2.96248115
85	flavonoid metabolic process (GO:0009812)	2.96054600
86	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.95099522
87	postsynaptic membrane organization (GO:0001941)	2.91987603
88	positive regulation of interleukin-17 production (GO:0032740)	2.91660893
89	notochord development (GO:0030903)	2.91195997
90	negative regulation of cell-matrix adhesion (GO:0001953)	2.90950482
91	rhodopsin mediated signaling pathway (GO:0016056)	2.90077677
92	regulation of interleukin-5 production (GO:0032674)	2.84178870
93	urate metabolic process (GO:0046415)	2.83411694
94	cellular response to gamma radiation (GO:0071480)	2.83179806
95	positive regulation of SMAD protein import into nucleus (GO:0060391)	2.82029375
96	heart valve formation (GO:0003188)	2.81621657
97	sulfation (GO:0051923)	2.79620669
98	growth hormone receptor signaling pathway (GO:0060396)	2.78737597
99	sulfur compound transport (GO:0072348)	2.78735009
100	sphingosine metabolic process (GO:0006670)	10.6191244

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	AR_21572438_ChIP-Seq_LNCaP_Human	3.25585755
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	3.24494328
3	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.87472044
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.85891357
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.74649912
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.61169610
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.51284783
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.33384252
9	VDR_22108803_ChIP-Seq_LS180_Human	2.27095348
10	P300_19829295_ChIP-Seq_ESCs_Human	2.19583239
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.13830592
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.03181033
13	GBX2_23144817_ChIP-Seq_PC3_Human	1.99616451
14	ER_23166858_ChIP-Seq_MCF-7_Human	1.96831235
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.89017173
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.86310043
17	HOXB7_26014856_ChIP-Seq_BT474_Human	1.86276149
18	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.79901297
19	NANOG_19829295_ChIP-Seq_ESCs_Human	1.78853845
20	SOX2_19829295_ChIP-Seq_ESCs_Human	1.78853845
21	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.77564988
22	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.75299578
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.74334286
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71994183
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.68627646
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.66898416
27	OCT4_20526341_ChIP-Seq_ESCs_Human	1.64374178
28	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.64320168
29	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.60234238
30	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.54643578
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54499086
32	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.54235043
33	STAT1_20625510_ChIP-Seq_HELA_Human	1.46863777
34	NCOR_22424771_ChIP-Seq_293T_Human	1.45702925
35	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.44192807
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43818571
37	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.43327483
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.43302152
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.42607463
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.40324167
41	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.35473750
42	STAT3_23295773_ChIP-Seq_U87_Human	1.34393006
43	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.34150282
44	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.32202055
45	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.29872805
46	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29752088
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.29469025
48	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.28733191
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27035859
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.26560224
51	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.26263462
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25531838
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.25405760
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25301665
55	CDX2_22108803_ChIP-Seq_LS180_Human	1.23945146
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23820030
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23720875
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23720875
59	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.23114594
60	TCF4_23295773_ChIP-Seq_U87_Human	1.22751818
61	FUS_26573619_Chip-Seq_HEK293_Human	1.22612492
62	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.22350154
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22280042
64	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.21796169
65	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20843487
66	AR_25329375_ChIP-Seq_VCAP_Human	1.20668911
67	P53_21459846_ChIP-Seq_SAOS-2_Human	1.19904297
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.17931901
69	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.16562999
70	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.16178806
71	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.13346850
72	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.13334361
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12344093
74	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11971053
75	CEBPB_22108803_ChIP-Seq_LS180_Human	1.10917716
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10116384
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.09834197
78	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.08308905
79	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08239009
80	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08203952
81	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07887345
82	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07321984
83	CBP_20019798_ChIP-Seq_JUKART_Human	1.07191290
84	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07191290
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05676112
86	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05447576
87	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.04994260
88	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04638144
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.04444940
90	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.03508700
91	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.03061863
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02569514
93	RAC3_21632823_ChIP-Seq_H3396_Human	1.02173423
94	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00504542
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99962837
96	GATA3_26560356_Chip-Seq_TH1_Human	0.99587134
97	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.97111947
98	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.96927953
99	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.96248215
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95480322

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	7.97473550
2	MP0003136_yellow_coat_color	6.50377224
3	MP0005171_absent_coat_pigmentation	6.17114911
4	MP0003646_muscle_fatigue	4.90189731
5	MP0002653_abnormal_ependyma_morphology	4.12521376
6	MP0003045_fibrosis	3.73130703
7	MP0003890_abnormal_embryonic-extraembry	3.43926608
8	MP0002234_abnormal_pharynx_morphology	3.41603396
9	MP0005670_abnormal_white_adipose	3.27857920
10	MP0005360_urolithiasis	3.05490098
11	MP0003879_abnormal_hair_cell	3.02499817
12	MP0000569_abnormal_digit_pigmentation	2.67808659
13	MP0004381_abnormal_hair_follicle	2.63732334
14	MP0002938_white_spotting	2.41861461
15	MP0005085_abnormal_gallbladder_physiolo	2.21613606
16	MP0002138_abnormal_hepatobiliary_system	2.07598682
17	MP0004147_increased_porphyrin_level	1.99651667
18	MP0002095_abnormal_skin_pigmentation	1.78898788
19	MP0005075_abnormal_melanosome_morpholog	1.63013631
20	MP0000749_muscle_degeneration	1.50236459
21	MP0005646_abnormal_pituitary_gland	1.48539377
22	MP0001873_stomach_inflammation	1.47027549
23	MP0003195_calcinosis	1.43800700
24	MP0004130_abnormal_muscle_cell	1.39860986
25	MP0002160_abnormal_reproductive_system	1.36576097
26	MP0003705_abnormal_hypodermis_morpholog	1.34177229
27	MP0003950_abnormal_plasma_membrane	1.31539995
28	MP0008875_abnormal_xenobiotic_pharmacok	1.30421304
29	MP0006292_abnormal_olfactory_placode	1.28412370
30	MP0002168_other_aberrant_phenotype	1.28264162
31	MP0002735_abnormal_chemical_nociception	1.27677316
32	MP0004885_abnormal_endolymph	1.16755509
33	MP0005410_abnormal_fertilization	1.12556323
34	MP0008872_abnormal_physiological_respon	1.10666768
35	MP0003878_abnormal_ear_physiology	1.08026954
36	MP0005377_hearing/vestibular/ear_phenot	1.08026954
37	MP0005365_abnormal_bile_salt	1.07762817
38	MP0005174_abnormal_tail_pigmentation	1.06730115
39	MP0001486_abnormal_startle_reflex	1.00640657
40	MP0001501_abnormal_sleep_pattern	0.97681840
41	MP0002075_abnormal_coat/hair_pigmentati	0.97050066
42	MP0003137_abnormal_impulse_conducting	0.95717905
43	MP0005551_abnormal_eye_electrophysiolog	0.94877012
44	MP0001968_abnormal_touch/_nociception	0.94410153
45	MP0001661_extended_life_span	0.84185599
46	MP0005389_reproductive_system_phenotype	0.84111340
47	MP0004043_abnormal_pH_regulation	0.83990104
48	MP0002876_abnormal_thyroid_physiology	0.83548521
49	MP0009745_abnormal_behavioral_response	0.83205194
50	MP0005395_other_phenotype	0.81141435
51	MP0002272_abnormal_nervous_system	0.80674765
52	MP0009046_muscle_twitch	0.79165550
53	MP0001186_pigmentation_phenotype	0.77654149
54	MP0002102_abnormal_ear_morphology	0.76063449
55	MP0003252_abnormal_bile_duct	0.75975673
56	MP0002736_abnormal_nociception_after	0.73192467
57	MP0001970_abnormal_pain_threshold	0.68817622
58	MP0004145_abnormal_muscle_electrophysio	0.66674892
59	MP0000015_abnormal_ear_pigmentation	0.65031543
60	MP0004142_abnormal_muscle_tone	0.64168590
61	MP0001984_abnormal_olfaction	0.63188138
62	MP0009764_decreased_sensitivity_to	0.62376697
63	MP0002733_abnormal_thermal_nociception	0.61794116
64	MP0005319_abnormal_enzyme/_coenzyme	0.61712177
65	MP0000026_abnormal_inner_ear	0.58907794
66	MP0002163_abnormal_gland_morphology	0.58186374
67	MP0005666_abnormal_adipose_tissue	0.56852779
68	MP0001764_abnormal_homeostasis	0.56151523
69	MP0000372_irregular_coat_pigmentation	0.54495171
70	MP0005330_cardiomyopathy	0.53689382
71	MP0005253_abnormal_eye_physiology	0.53650849
72	MP0000427_abnormal_hair_cycle	0.53283793
73	MP0002909_abnormal_adrenal_gland	0.52600690
74	MP0008877_abnormal_DNA_methylation	0.51882223
75	MP0001986_abnormal_taste_sensitivity	0.51061055
76	MP0003698_abnormal_male_reproductive	0.50489068
77	MP0002064_seizures	0.49296130
78	MP0002254_reproductive_system_inflammat	0.48716929
79	MP0010352_gastrointestinal_tract_polyps	0.48435260
80	MP0002572_abnormal_emotion/affect_behav	0.47688193
81	MP0009115_abnormal_fat_cell	0.46969263
82	MP0002332_abnormal_exercise_endurance	0.46331668
83	MP0008770_decreased_survivor_rate	0.46130929
84	MP0003937_abnormal_limbs/digits/tail_de	0.45588199
85	MP0002751_abnormal_autonomic_nervous	0.45386339
86	MP0008569_lethality_at_weaning	0.43270223
87	MP0002269_muscular_atrophy	0.42986147
88	MP0001800_abnormal_humoral_immune	0.42842722
89	MP0001790_abnormal_immune_system	0.42627570
90	MP0005387_immune_system_phenotype	0.42627570
91	MP0002210_abnormal_sex_determination	0.42470931
92	MP0001324_abnormal_eye_pigmentation	0.41456629
93	MP0004233_abnormal_muscle_weight	0.41349274
94	MP0002277_abnormal_respiratory_mucosa	0.40495205
95	MP0001905_abnormal_dopamine_level	0.39938986
96	MP0005647_abnormal_sex_gland	0.39879359
97	MP0003635_abnormal_synaptic_transmissio	0.39645941
98	MP0005334_abnormal_fat_pad	0.39280525
99	MP0005332_abnormal_amino_acid	0.38937591
100	MP0000470_abnormal_stomach_morphology	0.38410495

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Autoimmune hemolytic anemia (HP:0001890)	6.73617945
2	Focal motor seizures (HP:0011153)	6.44942601
3	Amelogenesis imperfecta (HP:0000705)	6.18976434
4	Autoimmune thrombocytopenia (HP:0001973)	6.18295828
5	Birth length less than 3rd percentile (HP:0003561)	5.73325017
6	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	5.49864786
7	Parakeratosis (HP:0001036)	5.18829202
8	Abnormal delayed hypersensitivity skin test (HP:0002963)	4.68905608
9	Increased IgM level (HP:0003496)	4.35662594
10	Acanthocytosis (HP:0001927)	4.23113730
11	Spontaneous hematomas (HP:0007420)	3.99354172
12	Aplastic anemia (HP:0001915)	3.50146413
13	Colon cancer (HP:0003003)	3.49295988
14	Dialeptic seizures (HP:0011146)	3.33138710
15	Pendular nystagmus (HP:0012043)	3.31669938
16	Congenital ichthyosiform erythroderma (HP:0007431)	3.21443899
17	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.20135578
18	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.16943586
19	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.16943586
20	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.14761163
21	Pancreatic cysts (HP:0001737)	2.99245874
22	Enlarged epiphyses (HP:0010580)	2.96921482
23	Neonatal hypoglycemia (HP:0001998)	2.94939469
24	Conjunctival telangiectasia (HP:0000524)	2.94210259
25	Lip pit (HP:0100267)	2.89048038
26	Hypochromic anemia (HP:0001931)	2.77271970
27	Congenital stationary night blindness (HP:0007642)	2.73971147
28	Abnormality of alanine metabolism (HP:0010916)	2.73338427
29	Hyperalaninemia (HP:0003348)	2.73338427
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.73338427
31	Proximal amyotrophy (HP:0007126)	2.73258786
32	Insulin-resistant diabetes mellitus (HP:0000831)	2.70991465
33	Abnormality of the fingertips (HP:0001211)	2.69669101
34	Hematochezia (HP:0002573)	2.66727256
35	Rectal prolapse (HP:0002035)	2.65601884
36	Esophageal varix (HP:0002040)	2.61138686
37	Focal seizures (HP:0007359)	2.60872130
38	Potter facies (HP:0002009)	2.60427090
39	Facial shape deformation (HP:0011334)	2.60427090
40	Congenital sensorineural hearing impairment (HP:0008527)	2.58729235
41	Abnormality of T cell physiology (HP:0011840)	2.55423670
42	Anterior segment dysgenesis (HP:0007700)	2.52655953
43	Constricted visual fields (HP:0001133)	2.52415834
44	Chin dimple (HP:0010751)	2.51367563
45	Eosinophilia (HP:0001880)	2.43454544
46	Abnormality of T cell number (HP:0011839)	2.40281473
47	Erythroderma (HP:0001019)	2.33615844
48	Enlarged kidneys (HP:0000105)	2.31378846
49	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.31085169
50	Glucose intolerance (HP:0000833)	2.30796923
51	Myotonia (HP:0002486)	2.30039674
52	Synostosis of carpal bones (HP:0005048)	2.28423386
53	Cerebellar dysplasia (HP:0007033)	2.24824168
54	Abnormality of the renal cortex (HP:0011035)	2.24557466
55	Hypoalbuminemia (HP:0003073)	2.20544064
56	Abnormal albumin level (HP:0012116)	2.20544064
57	Difficulty walking (HP:0002355)	2.15433980
58	Vertebral arch anomaly (HP:0008438)	2.15112471
59	Depressed nasal tip (HP:0000437)	2.11631931
60	Severe visual impairment (HP:0001141)	2.09739016
61	Type II lissencephaly (HP:0007260)	2.08289839
62	Poikilocytosis (HP:0004447)	2.06049813
63	Radial bowing (HP:0002986)	2.02928486
64	Abnormality of the renal medulla (HP:0100957)	2.01658147
65	Dehydration (HP:0001944)	1.99731978
66	Opisthotonus (HP:0002179)	1.95123824
67	Hypokalemia (HP:0002900)	1.94131649
68	Hyperglycemia (HP:0003074)	1.94043592
69	Progressive inability to walk (HP:0002505)	1.90790274
70	Broad ribs (HP:0000885)	1.87356489
71	Granulocytopenia (HP:0001913)	1.86571271
72	Decreased circulating renin level (HP:0003351)	1.85363584
73	Inability to walk (HP:0002540)	1.84959229
74	Abnormality of macular pigmentation (HP:0008002)	1.84443504
75	Nephronophthisis (HP:0000090)	1.83327003
76	Sparse lateral eyebrow (HP:0005338)	1.83001300
77	Non-midline cleft lip (HP:0100335)	1.82861365
78	Agammaglobulinemia (HP:0004432)	1.81443288
79	Pancreatic fibrosis (HP:0100732)	1.79247662
80	Renal tubular acidosis (HP:0001947)	1.79234433
81	Scapular winging (HP:0003691)	1.78588887
82	Epileptic encephalopathy (HP:0200134)	1.78355763
83	Abnormal drinking behavior (HP:0030082)	1.77136638
84	Polydipsia (HP:0001959)	1.77136638
85	Abnormality of eosinophils (HP:0001879)	1.76816819
86	Abnormality of the renal collecting system (HP:0004742)	1.75816628
87	Hypoplastic iliac wings (HP:0002866)	1.73993056
88	Portal hypertension (HP:0001409)	1.72796131
89	Duplicated collecting system (HP:0000081)	1.71842124
90	Neutropenia (HP:0001875)	1.69892142
91	Cavernous hemangioma (HP:0001048)	1.65948753
92	Coarctation of aorta (HP:0001680)	1.65582339
93	Generalized aminoaciduria (HP:0002909)	1.65435951
94	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.64110684
95	Gaze-evoked nystagmus (HP:0000640)	1.63595019
96	Conjugated hyperbilirubinemia (HP:0002908)	1.60362648
97	Lipid accumulation in hepatocytes (HP:0006561)	1.59682256
98	Abnormal glucose tolerance (HP:0001952)	1.58798197
99	Gangrene (HP:0100758)	1.58760121
100	Abnormality of T cells (HP:0002843)	1.56815351

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	8.22975302
2	STK38L	5.90407615
3	LATS2	5.08219628
4	TLK1	4.87891275
5	PIK3CA	3.34177905
6	FRK	2.74808697
7	CDK19	2.63571209
8	ZAK	2.47610737
9	NLK	2.39429989
10	ACVR1B	2.34903344
11	PRKD3	2.12729723
12	ADRBK2	2.11891392
13	MAP2K2	2.11701509
14	STK38	2.04020284
15	BMPR1B	1.97239171
16	GRK7	1.76460392
17	STK3	1.68325714
18	MELK	1.36040985
19	OXSR1	1.36025196
20	ADRBK1	1.31160816
21	TAF1	1.23162055
22	GRK5	1.20002235
23	CSNK1A1L	1.10377726
24	STK10	1.06766879
25	TGFBR2	1.04502505
26	WNK4	1.03084252
27	NEK1	0.99326430
28	MOS	0.94469788
29	TGFBR1	0.87701708
30	WNK3	0.84992062
31	STK11	0.81287031
32	MAP2K3	0.76171025
33	PRKCG	0.76000432
34	PIK3CG	0.74517292
35	PRKAA2	0.73232935
36	EIF2AK3	0.72734623
37	PDPK1	0.72458689
38	MAP2K6	0.72100136
39	KIT	0.69838796
40	RET	0.69213517
41	ERN1	0.66973797
42	MAP4K2	0.64069481
43	TXK	0.63473719
44	PRKD1	0.60808753
45	DAPK2	0.54349739
46	BMPR2	0.54038360
47	MAPK12	0.53696038
48	PINK1	0.48534549
49	NEK2	0.47652132
50	STK39	0.47144104
51	GRK1	0.46118736
52	MAP2K1	0.45612138
53	TAOK3	0.41104244
54	MAP3K2	0.38955605
55	INSRR	0.37633063
56	CSNK1D	0.37001311
57	CSNK1G3	0.35999043
58	IKBKB	0.34916644
59	IRAK3	0.34310086
60	CAMK1D	0.33424504
61	PDGFRB	0.32575704
62	PLK4	0.32473748
63	CAMK2A	0.32469708
64	TNK2	0.31541475
65	DYRK2	0.30811314
66	CSNK1G2	0.29130176
67	EIF2AK2	0.27714096
68	CAMKK2	0.27464393
69	PLK2	0.26482379
70	PRKACA	0.25446154
71	MARK3	0.24381070
72	CSNK1G1	0.24371545
73	JAK3	0.23789862
74	CSNK1A1	0.23542459
75	NEK9	0.21748182
76	PRKCI	0.20587883
77	CHEK2	0.18967532
78	PHKG2	0.18515590
79	PHKG1	0.18515590
80	PIM1	0.17666251
81	PRKG1	0.16600528
82	PTK2	0.16432193
83	SYK	0.14828550
84	PLK1	0.13457719
85	GRK6	0.12958705
86	CSNK2A1	0.11697549
87	PRKCE	0.11136213
88	ABL1	0.10985381
89	MAP3K8	0.10900235
90	AKT2	0.10659994
91	TIE1	0.10261756
92	PAK1	0.10008323
93	CCNB1	0.09512990
94	AURKA	0.09141360
95	OBSCN	0.09094520
96	JAK2	0.08623068
97	CSNK2A2	0.08517560
98	TEC	0.07769800
99	MAPKAPK5	0.07765874
100	PRKCA	0.07004225

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	5.68129714
2	Phototransduction_Homo sapiens_hsa04744	3.85660440
3	Nicotine addiction_Homo sapiens_hsa05033	3.14193713
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.93290883
5	Caffeine metabolism_Homo sapiens_hsa00232	2.88167038
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.63113831
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.60197057
8	African trypanosomiasis_Homo sapiens_hsa05143	2.43645230
9	Taste transduction_Homo sapiens_hsa04742	2.24584579
10	Sphingolipid metabolism_Homo sapiens_hsa00600	2.21677074
11	One carbon pool by folate_Homo sapiens_hsa00670	2.18106578
12	Morphine addiction_Homo sapiens_hsa05032	2.14781542
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.14406096
14	Allograft rejection_Homo sapiens_hsa05330	2.11782714
15	Graft-versus-host disease_Homo sapiens_hsa05332	2.09419239
16	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.01440173
17	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.99965133
18	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.91680628
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.90754308
20	Phenylalanine metabolism_Homo sapiens_hsa00360	1.85624303
21	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.81601843
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.79429909
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.75066544
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.71486887
25	GABAergic synapse_Homo sapiens_hsa04727	1.56910788
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.31954554
27	Sulfur relay system_Homo sapiens_hsa04122	1.22971210
28	Ribosome_Homo sapiens_hsa03010	1.19373642
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.18606086
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.16252624
31	Homologous recombination_Homo sapiens_hsa03440	1.16082011
32	Olfactory transduction_Homo sapiens_hsa04740	1.16022545
33	Viral myocarditis_Homo sapiens_hsa05416	1.14811293
34	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.13535227
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.06567006
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.03166415
37	Basal transcription factors_Homo sapiens_hsa03022	0.99654022
38	Serotonergic synapse_Homo sapiens_hsa04726	0.95730504
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.94172008
40	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.93857266
41	Calcium signaling pathway_Homo sapiens_hsa04020	0.93011314
42	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.91705586
43	Oxidative phosphorylation_Homo sapiens_hsa00190	0.89377077
44	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.84493308
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.84369618
46	Asthma_Homo sapiens_hsa05310	0.80907882
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.80823730
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79898873
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.79557470
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77939687
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74960853
52	Retinol metabolism_Homo sapiens_hsa00830	0.74052418
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.73139993
54	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.70510536
55	Butanoate metabolism_Homo sapiens_hsa00650	0.67896782
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64380913
57	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.63327750
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.60342945
59	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60094157
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.59346970
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58306432
62	ABC transporters_Homo sapiens_hsa02010	0.56413031
63	Fanconi anemia pathway_Homo sapiens_hsa03460	0.55594688
64	Rheumatoid arthritis_Homo sapiens_hsa05323	0.53431636
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53027599
66	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.52819835
67	Bile secretion_Homo sapiens_hsa04976	0.51216579
68	cAMP signaling pathway_Homo sapiens_hsa04024	0.51037618
69	Histidine metabolism_Homo sapiens_hsa00340	0.50441768
70	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.48255852
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.45404321
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44248022
73	Sulfur metabolism_Homo sapiens_hsa00920	0.43911954
74	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.43490491
75	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.42083046
76	Circadian entrainment_Homo sapiens_hsa04713	0.39203421
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38825925
78	Propanoate metabolism_Homo sapiens_hsa00640	0.38744171
79	Cholinergic synapse_Homo sapiens_hsa04725	0.38736021
80	Parkinsons disease_Homo sapiens_hsa05012	0.37392093
81	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.36274033
82	Salivary secretion_Homo sapiens_hsa04970	0.32690323
83	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.31315930
84	Folate biosynthesis_Homo sapiens_hsa00790	0.30502217
85	Metabolic pathways_Homo sapiens_hsa01100	0.29852144
86	VEGF signaling pathway_Homo sapiens_hsa04370	0.28782015
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.27412078
88	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.25672272
89	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.23506711
90	Huntingtons disease_Homo sapiens_hsa05016	0.22978082
91	Measles_Homo sapiens_hsa05162	0.22668965
92	Insulin secretion_Homo sapiens_hsa04911	0.22468947
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.22249829
94	Selenocompound metabolism_Homo sapiens_hsa00450	0.22103741
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.21918950
96	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.20775155
97	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.18611224
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.16966235
99	beta-Alanine metabolism_Homo sapiens_hsa00410	0.15895998
100	Hippo signaling pathway_Homo sapiens_hsa04390	0.15056345

R3HDM2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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