R3HDM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.56094372
2negative regulation of cell killing (GO:0031342)6.56094372
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.30463569
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.85979838
5positive regulation of gamma-delta T cell activation (GO:0046645)5.69718617
6modulation by symbiont of host defense response (GO:0052031)5.62625408
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.62625408
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.62625408
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.62625408
10modulation by symbiont of host immune response (GO:0052553)5.62625408
11positive regulation by symbiont of host defense response (GO:0052509)5.62625408
12antigen processing and presentation of endogenous antigen (GO:0019883)5.57698833
13synaptic vesicle maturation (GO:0016188)5.47490709
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.37964442
15neutrophil activation involved in immune response (GO:0002283)5.33360880
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.23733408
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.08744090
18locomotory exploration behavior (GO:0035641)5.06632420
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.99913059
20detection of other organism (GO:0098543)4.91240101
21detection of bacterium (GO:0016045)4.81606219
22vocalization behavior (GO:0071625)4.73462348
23regulation of B cell receptor signaling pathway (GO:0050855)4.72027339
24synaptic vesicle exocytosis (GO:0016079)4.60310513
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.58337414
26regulation of glutamate receptor signaling pathway (GO:1900449)4.56046816
27macrophage activation involved in immune response (GO:0002281)4.50628133
28regulation of synapse structural plasticity (GO:0051823)4.47963466
29regulation of neuronal synaptic plasticity (GO:0048168)4.47659827
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.45964006
31regulation of long-term neuronal synaptic plasticity (GO:0048169)4.38854774
32exploration behavior (GO:0035640)4.33996005
33G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.33294534
34response to interleukin-15 (GO:0070672)4.31027220
35response to peptidoglycan (GO:0032494)4.26982002
36negative regulation of lymphocyte mediated immunity (GO:0002707)4.26691878
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.25418943
38protein localization to synapse (GO:0035418)4.24664239
39glutamate secretion (GO:0014047)4.18453595
40regulation of gamma-delta T cell activation (GO:0046643)4.16451517
41neutrophil activation (GO:0042119)4.15047514
42neuronal action potential propagation (GO:0019227)4.14209720
43regulation of synaptic vesicle exocytosis (GO:2000300)4.13432830
44detection of external biotic stimulus (GO:0098581)4.12221927
45ionotropic glutamate receptor signaling pathway (GO:0035235)4.10856796
46cellular extravasation (GO:0045123)4.06626925
47negative regulation of interleukin-12 production (GO:0032695)4.06020958
48respiratory burst (GO:0045730)3.96145252
49leukocyte migration involved in inflammatory response (GO:0002523)3.95437723
50dendritic spine morphogenesis (GO:0060997)3.88292321
51regulation of synaptic vesicle transport (GO:1902803)3.88166375
52dendritic spine organization (GO:0097061)3.85398983
53cellular response to interleukin-15 (GO:0071350)3.84359449
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.83255297
55response to host immune response (GO:0052572)3.80882091
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.80882091
57regulation of interferon-beta biosynthetic process (GO:0045357)3.80689629
58negative regulation of leukocyte mediated immunity (GO:0002704)3.80369348
59detection of molecule of bacterial origin (GO:0032490)3.79764028
60granulocyte activation (GO:0036230)3.78354644
61regulation of gamma-delta T cell differentiation (GO:0045586)3.76215097
62positive regulation of membrane potential (GO:0045838)3.76150232
63negative regulation of erythrocyte differentiation (GO:0045647)3.75116083
64regulation of excitatory postsynaptic membrane potential (GO:0060079)3.73571562
65negative regulation of phagocytosis (GO:0050765)3.69967872
66positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.67472785
67immunoglobulin mediated immune response (GO:0016064)3.65106581
68positive regulation of neurotransmitter secretion (GO:0001956)3.64874358
69regulation of mast cell degranulation (GO:0043304)3.63653213
70synaptic transmission, glutamatergic (GO:0035249)3.62037729
71layer formation in cerebral cortex (GO:0021819)3.62033226
72long-term memory (GO:0007616)3.61378547
73negative regulation of T cell mediated immunity (GO:0002710)3.59971981
74detection of biotic stimulus (GO:0009595)3.56725432
75neurotransmitter-gated ion channel clustering (GO:0072578)3.54274949
76response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.53684079
77response to host (GO:0075136)3.53684079
78response to host defenses (GO:0052200)3.53684079
79myeloid cell activation involved in immune response (GO:0002275)3.51441113
80microglial cell activation (GO:0001774)3.51302459
81tolerance induction (GO:0002507)3.46893595
82regulation of synaptic plasticity (GO:0048167)3.45058073
83glutamate receptor signaling pathway (GO:0007215)3.43963017
84regulation of postsynaptic membrane potential (GO:0060078)3.43437620
85positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.41490560
86regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.40927499
87cellular response to type I interferon (GO:0071357)3.39888642
88type I interferon signaling pathway (GO:0060337)3.39888642
89positive regulation of vesicle fusion (GO:0031340)3.38664838
90response to type I interferon (GO:0034340)3.37352389
91neutrophil mediated immunity (GO:0002446)3.36090978
92regulation of dendritic spine morphogenesis (GO:0061001)3.35630219
93regulation of myeloid leukocyte mediated immunity (GO:0002886)3.34782782
94regulation of T cell tolerance induction (GO:0002664)3.34394197
95B cell receptor signaling pathway (GO:0050853)3.34276520
96membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34241678
97neuron cell-cell adhesion (GO:0007158)3.33925571
98positive regulation of synapse maturation (GO:0090129)3.33214584
99positive regulation of neurotransmitter transport (GO:0051590)3.32259167
100regulation of mast cell activation involved in immune response (GO:0033006)3.31773271
101macrophage activation (GO:0042116)3.31566102
102antigen processing and presentation via MHC class Ib (GO:0002475)3.30948782
103negative thymic T cell selection (GO:0045060)3.29020339
104postsynaptic membrane organization (GO:0001941)3.28971517
105germinal center formation (GO:0002467)3.28111224
106neuron-neuron synaptic transmission (GO:0007270)3.27768488
107regulation of leukocyte degranulation (GO:0043300)3.25155704
108leukocyte degranulation (GO:0043299)3.25019504
109regulation of B cell differentiation (GO:0045577)3.24696015
110regulation of vesicle fusion (GO:0031338)3.23310847
111response to muramyl dipeptide (GO:0032495)3.22394318
112neurotransmitter secretion (GO:0007269)3.21640710
113negative T cell selection (GO:0043383)3.20579143
114positive thymic T cell selection (GO:0045059)3.20303310
115positive regulation of B cell differentiation (GO:0045579)3.17904609
116positive regulation of mast cell activation (GO:0033005)3.14250324
117regulation of tolerance induction (GO:0002643)3.14079951
118regulation of T-helper 2 cell differentiation (GO:0045628)3.13163946
119negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.11894271
120negative regulation of T-helper cell differentiation (GO:0045623)3.11894271
121positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10466513
122long-term synaptic potentiation (GO:0060291)3.07804656
123regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.07793377
124regulation of natural killer cell mediated immunity (GO:0002715)3.07793377
125production of molecular mediator involved in inflammatory response (GO:0002532)3.06646839
126neuronal ion channel clustering (GO:0045161)3.04759797
127adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.04494465
128defense response to protozoan (GO:0042832)3.02723116
129oxygen transport (GO:0015671)3.02302855
130positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02284679
131regulation of mast cell activation (GO:0033003)3.00855161
132positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99465678
133behavioral defense response (GO:0002209)2.99132481
134behavioral fear response (GO:0001662)2.99132481
135regulation of dendritic spine development (GO:0060998)2.97824063
136negative regulation of cytokine production involved in immune response (GO:0002719)2.95388261
137positive regulation of dendritic spine development (GO:0060999)2.95007367
138regulation of T cell mediated cytotoxicity (GO:0001914)2.93822313
139auditory behavior (GO:0031223)2.93286593
140negative regulation of interleukin-6 production (GO:0032715)2.92433447
141positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.92409010
142negative regulation of innate immune response (GO:0045824)2.91965486
143regulation of alpha-beta T cell proliferation (GO:0046640)2.90914264
144regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90897846
145B cell mediated immunity (GO:0019724)2.90852505
146positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90083180
147presynaptic membrane organization (GO:0097090)2.88883478
148regulation of platelet aggregation (GO:0090330)2.88339059
149T cell selection (GO:0045058)2.88136052
150lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87671937
151negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87589266
152negative regulation of type 2 immune response (GO:0002829)2.87455350
153positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87152567
154myeloid leukocyte mediated immunity (GO:0002444)2.87113004
155negative regulation of alpha-beta T cell activation (GO:0046636)2.86949652
156activation of protein kinase A activity (GO:0034199)2.83970789
157cellular potassium ion homeostasis (GO:0030007)2.81286200
158learning (GO:0007612)2.80560379
159leukocyte aggregation (GO:0070486)2.79906759
160visual learning (GO:0008542)2.79643320
161dopamine receptor signaling pathway (GO:0007212)2.79340619
162regulation of neurotransmitter secretion (GO:0046928)2.77644444
163neuron recognition (GO:0008038)2.77503034
164sodium ion export (GO:0071436)2.76017918
165neuromuscular process controlling balance (GO:0050885)2.72837168
166innervation (GO:0060384)2.71088350
167membrane depolarization (GO:0051899)2.70962207
168synaptic vesicle endocytosis (GO:0048488)2.70902012
169axonal fasciculation (GO:0007413)2.70667943
170regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70252620
171response to auditory stimulus (GO:0010996)2.70102608
172positive regulation of synaptic transmission (GO:0050806)2.69718476
173regulation of synaptic transmission, glutamatergic (GO:0051966)2.69163619
174fear response (GO:0042596)2.67745962
175regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.66105483
176signal complex assembly (GO:0007172)2.65789315
177barbed-end actin filament capping (GO:0051016)2.65538423
178response to histamine (GO:0034776)2.64825974
179presynaptic membrane assembly (GO:0097105)2.64759629
180regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.64707884
181cell communication by electrical coupling (GO:0010644)2.63452494
182prepulse inhibition (GO:0060134)2.61022952
183regulation of neurotransmitter transport (GO:0051588)2.60888140
184response to amphetamine (GO:0001975)2.60412374
185regulation of female receptivity (GO:0045924)2.60049180
186regulation of synapse maturation (GO:0090128)2.59978619
187regulation of synaptic transmission (GO:0050804)2.59216674
188chemosensory behavior (GO:0007635)2.58804483
189visual behavior (GO:0007632)2.55544892
190positive regulation of dendritic spine morphogenesis (GO:0061003)2.55362267
191associative learning (GO:0008306)2.54906897
192membrane hyperpolarization (GO:0060081)2.54844082
193regulation of voltage-gated calcium channel activity (GO:1901385)2.53205543
194cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.51807752
195negative regulation of dendrite development (GO:2000171)2.49981689
196regulation of ARF protein signal transduction (GO:0032012)2.48995959
197mechanosensory behavior (GO:0007638)2.48387449
198regulation of ion transmembrane transporter activity (GO:0032412)2.47627899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58957523
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.18110095
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.24106420
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08337297
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.94814122
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92122435
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.90606804
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.87952663
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.83459141
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83254111
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81277117
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79846962
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79846962
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.77703429
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.70501068
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58314664
17MAF_26560356_Chip-Seq_TH1_Human2.54374562
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.53275231
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.51868218
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50738069
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50612039
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50549056
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47459788
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45822973
25SPI1_23547873_ChIP-Seq_NB4_Human2.44955163
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44809504
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.42590788
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.37958109
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.36650005
30DROSHA_22980978_ChIP-Seq_HELA_Human2.34584346
31UTX_26944678_Chip-Seq_JUKART_Human2.33731408
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.31803641
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30591287
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26531424
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.25536641
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.20437070
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17504862
38GBX2_23144817_ChIP-Seq_PC3_Human2.15224200
39MYB_26560356_Chip-Seq_TH2_Human2.13850030
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12663171
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10335625
42REST_21632747_ChIP-Seq_MESCs_Mouse2.10237081
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.10057654
44BRD4_27068464_Chip-Seq_AML-cells_Mouse2.09232705
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08462446
46STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07735570
47EED_16625203_ChIP-ChIP_MESCs_Mouse2.07125698
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.98465582
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.98187066
50MAF_26560356_Chip-Seq_TH2_Human1.96409020
51MYB_26560356_Chip-Seq_TH1_Human1.96376592
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.90964490
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.90029270
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88650148
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.84133842
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81049533
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80877731
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.80326035
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64046540
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63690108
61KDM2B_26808549_Chip-Seq_K562_Human1.62882165
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61926791
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61237431
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60852486
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.58228024
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57153766
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52987140
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52971464
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52346780
70LXR_22292898_ChIP-Seq_THP-1_Human1.50274605
71GATA3_27048872_Chip-Seq_THYMUS_Human1.48971557
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47823232
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47512002
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45649440
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44727233
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.43286281
77AR_21572438_ChIP-Seq_LNCaP_Human1.41812787
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41216283
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40047554
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39288052
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.37334288
82GATA1_22025678_ChIP-Seq_K562_Human1.37167011
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36545384
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35598632
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.33818569
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31766199
87KDM2B_26808549_Chip-Seq_DND41_Human1.31487316
88NCOR1_26117541_ChIP-Seq_K562_Human1.30765806
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29824631
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25588914
91BCL6_27268052_Chip-Seq_Bcells_Human1.25332775
92GATA2_19941826_ChIP-Seq_K562_Human1.23516717
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21917106
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21046478
95BCOR_27268052_Chip-Seq_Bcells_Human1.20963372
96VDR_24787735_ChIP-Seq_THP-1_Human1.20932970
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20370432
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19555138
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19173922
100RACK7_27058665_Chip-Seq_MCF-7_Human1.18453573
101ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18323646
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17860971
103SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16678593
104SCL_19346495_ChIP-Seq_HPC-7_Human1.16388584
105SPI1_23127762_ChIP-Seq_K562_Human1.16097193
106PU_27001747_Chip-Seq_BMDM_Mouse1.15052436
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.14987018
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14538243
109RXR_22108803_ChIP-Seq_LS180_Human1.14253163
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14185571
111CTCF_27219007_Chip-Seq_Bcells_Human1.14090029
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.13061573
113SA1_27219007_Chip-Seq_ERYTHROID_Human1.12353365
114ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11075148
115CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10118190
116TP53_20018659_ChIP-ChIP_R1E_Mouse1.08726126
117GATA1_19941827_ChIP-Seq_MEL_Mouse1.07608121
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07007132
119TCF7_22412390_ChIP-Seq_EML_Mouse1.06926469
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06098703
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05410316
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03364806
123ELF1_20517297_ChIP-Seq_JURKAT_Human1.03013458
124VDR_21846776_ChIP-Seq_THP-1_Human1.01360980
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00603492
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98811267
127RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98736248
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97801161
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97299463
130GATA3_26560356_Chip-Seq_TH2_Human0.95944777
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95378361
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94036897
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93358373
134KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93199648
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92628056
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92467023
137ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91023841
138EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90455713
139VDR_24763502_ChIP-Seq_THP-1_Human0.90245400
140MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89680934
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89550327
142SMC4_20622854_ChIP-Seq_HELA_Human0.89463301
143VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88750380
144LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88540149
145CTCF_21964334_ChIP-Seq_BJAB-B_Human0.88442412
146TET1_21490601_ChIP-Seq_MESCs_Mouse0.88207494
147CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86286891
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84835710
149AR_19668381_ChIP-Seq_PC3_Human0.84682511
150SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80594095
151GATA1_19941826_ChIP-Seq_K562_Human0.80496267
152EGR1_19032775_ChIP-ChIP_M12_Human0.79958945
153CREB1_26743006_Chip-Seq_LNCaP_Human0.79315294
154ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78492609
155KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77844031
156P68_20966046_ChIP-Seq_HELA_Human0.76808151
157SMAD4_21799915_ChIP-Seq_A2780_Human0.76534610
158CTBP2_25329375_ChIP-Seq_LNCAP_Human0.76451272
159CBX2_27304074_Chip-Seq_ESCs_Mouse0.75947283
160RUNX_20019798_ChIP-Seq_JUKART_Human0.75609484
161MYC_22102868_ChIP-Seq_BL_Human0.74808998
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.73644505
163GATA2_21666600_ChIP-Seq_HMVEC_Human0.72574755
164SMAD4_21741376_ChIP-Seq_HESCs_Human0.72442620
165AHR_22903824_ChIP-Seq_MCF-7_Human0.71738817
166UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.71290350
167E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.71117138
168AR_25329375_ChIP-Seq_VCAP_Human0.70662105
169SMAD3_21741376_ChIP-Seq_HESCs_Human0.70607508

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.36093387
2MP0003724_increased_susceptibility_to4.65223259
3MP0003880_abnormal_central_pattern4.19901852
4MP0003635_abnormal_synaptic_transmissio4.12111345
5MP0001835_abnormal_antigen_presentation3.37031838
6MP0002063_abnormal_learning/memory/cond3.33607785
7MP0002822_catalepsy3.25803382
8MP0004270_analgesia3.24796426
9MP0009745_abnormal_behavioral_response3.18132814
10MP0002419_abnormal_innate_immunity2.99387484
11MP0005025_abnormal_response_to2.83296829
12MP0002064_seizures2.81404267
13MP0001800_abnormal_humoral_immune2.79579263
14MP0005387_immune_system_phenotype2.78281797
15MP0001790_abnormal_immune_system2.78281797
16MP0005671_abnormal_response_to2.76116678
17MP0005000_abnormal_immune_tolerance2.75442441
18MP0000685_abnormal_immune_system2.72686182
19MP0003300_gastrointestinal_ulcer2.62096538
20MP0005423_abnormal_somatic_nervous2.61023876
21MP0002572_abnormal_emotion/affect_behav2.55596480
22MP0002420_abnormal_adaptive_immunity2.51778098
23MP0002723_abnormal_immune_serum2.51577011
24MP0001819_abnormal_immune_cell2.49296034
25MP0003763_abnormal_thymus_physiology2.46725814
26MP0002452_abnormal_antigen_presenting2.38825425
27MP0001486_abnormal_startle_reflex2.37048477
28MP0001968_abnormal_touch/_nociception2.33008895
29MP0006082_CNS_inflammation2.32611487
30MP0008260_abnormal_autophagy2.30180208
31MP0003191_abnormal_cellular_cholesterol2.25549415
32MP0002272_abnormal_nervous_system2.15849807
33MP0002148_abnormal_hypersensitivity_rea2.14099812
34MP0001533_abnormal_skeleton_physiology2.12542793
35MP0002405_respiratory_system_inflammati2.10753686
36MP0008569_lethality_at_weaning2.10248528
37MP0002398_abnormal_bone_marrow2.09786208
38MP0002132_abnormal_respiratory_system2.08997223
39MP0009046_muscle_twitch2.08569759
40MP0004858_abnormal_nervous_system1.99656323
41MP0003075_altered_response_to1.92894187
42MP0000716_abnormal_immune_system1.92304419
43MP0010155_abnormal_intestine_physiology1.91670518
44MP0003329_amyloid_beta_deposits1.91483124
45MP0003879_abnormal_hair_cell1.89030956
46MP0004811_abnormal_neuron_physiology1.88289231
47MP0004947_skin_inflammation1.85110045
48MP0002837_dystrophic_cardiac_calcinosis1.84687372
49MP0009333_abnormal_splenocyte_physiolog1.83837394
50MP0002734_abnormal_mechanical_nocicepti1.82235938
51MP0005451_abnormal_body_composition1.81951675
52MP0000465_gastrointestinal_hemorrhage1.76550803
53MP0001501_abnormal_sleep_pattern1.76511792
54MP0001970_abnormal_pain_threshold1.76038966
55MP0003866_abnormal_defecation1.75289969
56MP0002736_abnormal_nociception_after1.73307769
57MP0002722_abnormal_immune_system1.71288647
58MP0002396_abnormal_hematopoietic_system1.71108304
59MP0002909_abnormal_adrenal_gland1.69438091
60MP0002735_abnormal_chemical_nociception1.69244651
61MP0000689_abnormal_spleen_morphology1.68570020
62MP0001845_abnormal_inflammatory_respons1.68264156
63MP0000703_abnormal_thymus_morphology1.64667286
64MP0002733_abnormal_thermal_nociception1.62538498
65MP0009780_abnormal_chondrocyte_physiolo1.61022475
66MP0002557_abnormal_social/conspecific_i1.60917198
67MP0002429_abnormal_blood_cell1.60093416
68MP0003828_pulmonary_edema1.56861920
69MP0004381_abnormal_hair_follicle1.51623963
70MP0005646_abnormal_pituitary_gland1.49351757
71MP0001984_abnormal_olfaction1.48343200
72MP0005499_abnormal_olfactory_system1.44151506
73MP0005394_taste/olfaction_phenotype1.44151506
74MP0000778_abnormal_nervous_system1.43775528
75MP0000858_altered_metastatic_potential1.43613890
76MP0002067_abnormal_sensory_capabilities1.41997540
77MP0002184_abnormal_innervation1.41772857
78MP0001440_abnormal_grooming_behavior1.41589593
79MP0005409_darkened_coat_color1.39846909
80MP0008469_abnormal_protein_level1.37929232
81MP0003656_abnormal_erythrocyte_physiolo1.37753879
82MP0000955_abnormal_spinal_cord1.35559222
83MP0009764_decreased_sensitivity_to1.33582737
84MP0003633_abnormal_nervous_system1.32962978
85MP0001502_abnormal_circadian_rhythm1.32060340
86MP0002882_abnormal_neuron_morphology1.26869087
87MP0008874_decreased_physiological_sensi1.25971670
88MP0003303_peritoneal_inflammation1.20925376
89MP0002653_abnormal_ependyma_morphology1.19834996
90MP0001905_abnormal_dopamine_level1.17011387
91MP0005386_behavior/neurological_phenoty1.15700261
92MP0004924_abnormal_behavior1.15700261
93MP0005083_abnormal_biliary_tract1.14565728
94MP0002998_abnormal_bone_remodeling1.14356166
95MP0001873_stomach_inflammation1.13649829
96MP0002066_abnormal_motor_capabilities/c1.13319825
97MP0008789_abnormal_olfactory_epithelium1.11669673
98MP0004885_abnormal_endolymph1.11314557
99MP0008004_abnormal_stomach_pH1.08409836
100MP0000490_abnormal_crypts_of1.07754735
101MP0001529_abnormal_vocalization1.06994893
102MP0005058_abnormal_lysosome_morphology1.05751040
103MP0003183_abnormal_peptide_metabolism1.05478603
104MP0005167_abnormal_blood-brain_barrier1.05214825
105MP0005166_decreased_susceptibility_to1.01463577
106MP0001663_abnormal_digestive_system1.00687546
107MP0003631_nervous_system_phenotype0.99959853
108MP0001664_abnormal_digestion0.97561536
109MP0000920_abnormal_myelination0.96940141
110MP0004808_abnormal_hematopoietic_stem0.94988684
111MP0005164_abnormal_response_to0.94154800
112MP0001188_hyperpigmentation0.91177853
113MP0005075_abnormal_melanosome_morpholog0.89247239
114MP0005390_skeleton_phenotype0.89152138
115MP0002152_abnormal_brain_morphology0.87264744
116MP0000631_abnormal_neuroendocrine_gland0.86462698
117MP0005645_abnormal_hypothalamus_physiol0.86350965
118MP0004510_myositis0.86270068
119MP0009278_abnormal_bone_marrow0.85932438
120MP0008961_abnormal_basal_metabolism0.85597404
121MP0005310_abnormal_salivary_gland0.85398920
122MP0003436_decreased_susceptibility_to0.84626674
123MP0009763_increased_sensitivity_to0.83803678
124MP0000343_altered_response_to0.83381015
125MP0000751_myopathy0.82641153
126MP0003448_altered_tumor_morphology0.80584241
127MP0002069_abnormal_eating/drinking_beha0.79813244
128MP0003690_abnormal_glial_cell0.79239606
129MP0003453_abnormal_keratinocyte_physiol0.76041603
130MP0006292_abnormal_olfactory_placode0.73212354
131MP0003045_fibrosis0.72803858
132MP0000015_abnormal_ear_pigmentation0.72305480
133MP0004085_abnormal_heartbeat0.71341937
134MP0002166_altered_tumor_susceptibility0.71188184
135MP0002933_joint_inflammation0.71111616
136MP0002277_abnormal_respiratory_mucosa0.70598384
137MP0003566_abnormal_cell_adhesion0.69133163
138MP0004142_abnormal_muscle_tone0.68936901
139MP0000678_abnormal_parathyroid_gland0.68911053
140MP0010234_abnormal_vibrissa_follicle0.68529397
141MP0009765_abnormal_xenobiotic_induced0.68057087
142MP0003795_abnormal_bone_structure0.67967436
143MP0004484_altered_response_of0.67494728
144MP0005377_hearing/vestibular/ear_phenot0.66780437
145MP0003878_abnormal_ear_physiology0.66780437
146MP0001177_atelectasis0.66419453
147MP0009840_abnormal_foam_cell0.66278745
148MP0008872_abnormal_physiological_respon0.64883873
149MP0001853_heart_inflammation0.64290347
150MP0003705_abnormal_hypodermis_morpholog0.64256325
151MP0000681_abnormal_thyroid_gland0.64161639
152MP0003787_abnormal_imprinting0.63876703
153MP0002138_abnormal_hepatobiliary_system0.62622589
154MP0003806_abnormal_nucleotide_metabolis0.62221508
155MP0000249_abnormal_blood_vessel0.61788746
156MP0006276_abnormal_autonomic_nervous0.61736651
157MP0000534_abnormal_ureter_morphology0.61292120
158MP0004130_abnormal_muscle_cell0.60586265
159MP0005397_hematopoietic_system_phenotyp0.60103978
160MP0001545_abnormal_hematopoietic_system0.60103978
161MP0005381_digestive/alimentary_phenotyp0.60085274
162MP0000604_amyloidosis0.60032798
163MP0005076_abnormal_cell_differentiation0.59575038
164MP0000749_muscle_degeneration0.58906613
165MP0004145_abnormal_muscle_electrophysio0.57865212
166MP0002234_abnormal_pharynx_morphology0.57741079
167MP0003137_abnormal_impulse_conducting0.56852967
168MP0003091_abnormal_cell_migration0.56650905
169MP0002332_abnormal_exercise_endurance0.56301985
170MP0002752_abnormal_somatic_nervous0.55543893
171MP0003221_abnormal_cardiomyocyte_apopto0.55503617
172MP0002019_abnormal_tumor_incidence0.54913050
173MP0009785_altered_susceptibility_to0.54292936
174MP0005535_abnormal_body_temperature0.54198583
175MP0002089_abnormal_postnatal_growth/wei0.53866849
176MP0001851_eye_inflammation0.53126283
177MP0002229_neurodegeneration0.50979645
178MP0005464_abnormal_platelet_physiology0.50812231
179MP0004883_abnormal_blood_vessel0.49994681
180MP0001943_abnormal_respiration0.49443397
181MP0003172_abnormal_lysosome_physiology0.48063477

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.77156982
2Myokymia (HP:0002411)6.68638191
3Myositis (HP:0100614)5.59617849
4Hypochromic microcytic anemia (HP:0004840)5.47905801
5Abnormality of macrophages (HP:0004311)5.23565352
6Orchitis (HP:0100796)5.15799515
7Focal seizures (HP:0007359)4.98229874
8Stomatitis (HP:0010280)4.92312348
9Visual hallucinations (HP:0002367)4.74633220
10Retrobulbar optic neuritis (HP:0100654)4.66089568
11Optic neuritis (HP:0100653)4.66089568
12Elevated erythrocyte sedimentation rate (HP:0003565)4.56456797
13Febrile seizures (HP:0002373)4.48428126
14Recurrent gram-negative bacterial infections (HP:0005420)4.45492958
15Epileptic encephalopathy (HP:0200134)4.41591257
16Prolonged bleeding time (HP:0003010)4.34859032
17Hypochromic anemia (HP:0001931)4.21568759
18Gastrointestinal infarctions (HP:0005244)4.14999180
19Recurrent fungal infections (HP:0002841)3.89080815
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.86377859
21Increased IgE level (HP:0003212)3.86310983
22Meningitis (HP:0001287)3.82113221
23Atonic seizures (HP:0010819)3.81343264
24Annular pancreas (HP:0001734)3.75893652
25Encephalitis (HP:0002383)3.60251785
26Urticaria (HP:0001025)3.57293857
27Recurrent skin infections (HP:0001581)3.54979601
28Petechiae (HP:0000967)3.45503795
29Abnormality of the heme biosynthetic pathway (HP:0010472)3.45286656
30Broad-based gait (HP:0002136)3.43560640
31Keratoconjunctivitis sicca (HP:0001097)3.39969777
32Ankle clonus (HP:0011448)3.38451837
33Gingivitis (HP:0000230)3.36573454
34Microcytic anemia (HP:0001935)3.35361879
35Cellulitis (HP:0100658)3.33264205
36Papilledema (HP:0001085)3.31858569
37Vasculitis (HP:0002633)3.31472097
38Stereotypic behavior (HP:0000733)3.29250261
39Epistaxis (HP:0000421)3.24707533
40Gingival bleeding (HP:0000225)3.19517976
41Absence seizures (HP:0002121)3.16166295
42Episodic fever (HP:0001954)3.14566061
43Chest pain (HP:0100749)3.11666305
44Depression (HP:0000716)3.11068628
45Keratoconjunctivitis (HP:0001096)3.10296158
46Action tremor (HP:0002345)3.05220851
47Generalized tonic-clonic seizures (HP:0002069)3.03310853
48Recurrent cutaneous fungal infections (HP:0011370)3.01867975
49Chronic mucocutaneous candidiasis (HP:0002728)3.01867975
50Poor eye contact (HP:0000817)2.99326734
51Pustule (HP:0200039)2.98480863
52Dialeptic seizures (HP:0011146)2.94969152
53Anxiety (HP:0000739)2.94945014
54Inflammation of the large intestine (HP:0002037)2.93095258
55Torticollis (HP:0000473)2.92896136
56Gastrointestinal inflammation (HP:0004386)2.92420769
57Abnormal eating behavior (HP:0100738)2.91347746
58Progressive cerebellar ataxia (HP:0002073)2.89005773
59Amblyopia (HP:0000646)2.85478008
60Purpura (HP:0000979)2.83557739
61Abnormal platelet volume (HP:0011876)2.82174360
62Spinal canal stenosis (HP:0003416)2.80824823
63Obstructive sleep apnea (HP:0002870)2.80701536
64Peritonitis (HP:0002586)2.77815124
65T lymphocytopenia (HP:0005403)2.77580698
66Increased IgM level (HP:0003496)2.75066055
67Focal dystonia (HP:0004373)2.73488175
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.73430951
69Leukocytosis (HP:0001974)2.70881389
70Centrally nucleated skeletal muscle fibers (HP:0003687)2.69180833
71Panhypogammaglobulinemia (HP:0003139)2.67250146
72Anorexia (HP:0002039)2.65439719
73Pulmonary infiltrates (HP:0002113)2.65153227
74Supranuclear gaze palsy (HP:0000605)2.62542522
75Abnormality of T cell number (HP:0011839)2.62229053
76Recurrent viral infections (HP:0004429)2.61493006
77Arterial thrombosis (HP:0004420)2.60531234
78Hemoptysis (HP:0002105)2.60487706
79Nonprogressive disorder (HP:0003680)2.56081435
80Lower limb amyotrophy (HP:0007210)2.52484011
81Osteomyelitis (HP:0002754)2.51868005
82Hyperventilation (HP:0002883)2.51173975
83Abnormality of T cells (HP:0002843)2.50976217
84Granulocytopenia (HP:0001913)2.49755062
85Pulmonary embolism (HP:0002204)2.48561103
86Impaired social interactions (HP:0000735)2.47841405
87Abnormal social behavior (HP:0012433)2.47841405
88Urinary bladder sphincter dysfunction (HP:0002839)2.46355907
89Gaze-evoked nystagmus (HP:0000640)2.43723396
90Postural instability (HP:0002172)2.42554347
91Craniofacial dystonia (HP:0012179)2.42312189
92Lymphopenia (HP:0001888)2.42308768
93Slow saccadic eye movements (HP:0000514)2.39968877
94Mutism (HP:0002300)2.36659139
95Polycythemia (HP:0001901)2.36254181
96Pointed chin (HP:0000307)2.34155029
97Genetic anticipation (HP:0003743)2.31617388
98Sepsis (HP:0100806)2.30980554
99Truncal ataxia (HP:0002078)2.30883047
100Hypergammaglobulinemia (HP:0010702)2.27665939
101Amyloidosis (HP:0011034)2.26730980
102Abnormality of cells of the lymphoid lineage (HP:0012140)2.26435281
103Abnormal hemoglobin (HP:0011902)2.22784448
104Impaired vibration sensation in the lower limbs (HP:0002166)2.21931743
105Abnormality of T cell physiology (HP:0011840)2.21161793
106Dysmetria (HP:0001310)2.19508224
107Increased serum ferritin (HP:0003281)2.18540641
108Abnormal EKG (HP:0003115)2.18400913
109Spontaneous hematomas (HP:0007420)2.18375002
110Colitis (HP:0002583)2.17476817
111Hypoventilation (HP:0002791)2.15705649
112Sleep apnea (HP:0010535)2.12871661
113Hepatosplenomegaly (HP:0001433)2.12067466
114Abnormality of iron homeostasis (HP:0011031)2.12024290
115Eczematoid dermatitis (HP:0000976)2.08961426
116Toxemia of pregnancy (HP:0100603)2.07761358
117Megalencephaly (HP:0001355)2.07570258
118Recurrent abscess formation (HP:0002722)2.07379591
119Acne (HP:0001061)2.06596478
120Distal lower limb amyotrophy (HP:0008944)2.06529612
121Menorrhagia (HP:0000132)2.05451883
122Abnormality of the peritoneum (HP:0002585)2.05028436
123Skin ulcer (HP:0200042)2.04083946
124Progressive microcephaly (HP:0000253)2.03857804
125Abnormality of the pleura (HP:0002103)2.03801931
126Glomerulopathy (HP:0100820)2.03198591
127Impaired smooth pursuit (HP:0007772)2.02441711
128Dysmetric saccades (HP:0000641)2.02410093
129Gangrene (HP:0100758)2.01662885
130Mediastinal lymphadenopathy (HP:0100721)2.01488587
131Dysdiadochokinesis (HP:0002075)1.99879513
132Hypercortisolism (HP:0001578)1.98493167
133Abnormality of the pericardium (HP:0001697)1.97870463
134Exercise-induced myalgia (HP:0003738)1.97672253
135Primary atrial arrhythmia (HP:0001692)1.95902406
136Premature loss of primary teeth (HP:0006323)1.95483103
137Nasal polyposis (HP:0100582)1.94902164
138IgM deficiency (HP:0002850)1.94606817
139Bundle branch block (HP:0011710)1.93688417
140Apathy (HP:0000741)1.92888048
141Heterochromia iridis (HP:0001100)1.92111821
142Supraventricular tachycardia (HP:0004755)1.92049862
143Eosinophilia (HP:0001880)1.91610093
144Increased variability in muscle fiber diameter (HP:0003557)1.91371725
145Scanning speech (HP:0002168)1.91365396
146Ventricular fibrillation (HP:0001663)1.91253718
147Agammaglobulinemia (HP:0004432)1.90907023
148Large eyes (HP:0001090)1.90458232
149Hemiplegia (HP:0002301)1.90136296
150Papilloma (HP:0012740)1.88407349
151Verrucae (HP:0200043)1.88407349
152Increased mean platelet volume (HP:0011877)1.88352251
153Insomnia (HP:0100785)1.87921099
154Metaphyseal cupping (HP:0003021)1.87441792
155Failure to thrive in infancy (HP:0001531)1.87334313
156Urinary urgency (HP:0000012)1.86902477
157Deeply set eye (HP:0000490)1.86423706
158Diminished motivation (HP:0000745)1.86357451
159Abnormality of binocular vision (HP:0011514)1.86027863
160Diplopia (HP:0000651)1.86027863
161Chronic otitis media (HP:0000389)1.85749984
162Spastic gait (HP:0002064)1.85738612
163Bradykinesia (HP:0002067)1.85389689
164Acute hepatic failure (HP:0006554)1.85189999
165Progressive inability to walk (HP:0002505)1.85076221
166Atrial fibrillation (HP:0005110)1.85061783
167Hypertensive crisis (HP:0100735)1.83863719
168Segmental peripheral demyelination/remyelination (HP:0003481)1.83839502
169Fetal akinesia sequence (HP:0001989)1.82954399
170Gastrointestinal stroma tumor (HP:0100723)1.82919265
171Loss of speech (HP:0002371)1.82763398
172Viral hepatitis (HP:0006562)1.82529527
173Abnormality of skeletal muscle fiber size (HP:0012084)1.82168695
174Supraventricular arrhythmia (HP:0005115)1.81239604
175Ankyloglossia (HP:0010296)1.80319196
176Vertigo (HP:0002321)1.80250295
177Iris hypopigmentation (HP:0007730)1.78598848
178Rapidly progressive (HP:0003678)1.77907046
179Agitation (HP:0000713)1.77665684
180Recurrent bacterial skin infections (HP:0005406)1.77283880
181Palpebral edema (HP:0100540)1.77035547
182Lower limb asymmetry (HP:0100559)1.76160582
183Incomplete penetrance (HP:0003829)1.74207877
184Cortical visual impairment (HP:0100704)1.74129621
185Bradycardia (HP:0001662)1.74012135
186Amyotrophic lateral sclerosis (HP:0007354)1.73958353
187Ocular albinism (HP:0001107)1.73513444
188Chronic obstructive pulmonary disease (HP:0006510)1.73276872
189Obstructive lung disease (HP:0006536)1.73276872
190Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72989838
191Intellectual disability, severe (HP:0010864)1.72615235
192Epileptiform EEG discharges (HP:0011182)1.72562695
193Anosmia (HP:0000458)1.72225058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.65030730
2MAP4K13.67144121
3MAP2K33.23828184
4MAP3K93.23774744
5NTRK33.17602355
6MAP3K122.73224386
7DAPK22.68835241
8RIPK42.49672643
9TYK22.47338200
10PRPF4B2.39433237
11EPHB12.31555194
12MAP3K32.19551809
13KSR22.16142294
14MINK12.09222350
15TAOK12.06144479
16ZAP702.03924357
17MAP2K72.00839651
18CDK191.84201506
19DAPK11.83152252
20KSR11.72233024
21NTRK21.72004409
22JAK31.67116587
23TNIK1.65317286
24MARK11.64351671
25PAK61.59087754
26ARAF1.57383942
27CAMKK11.53685054
28FES1.53020895
29SIK31.51951464
30MAP3K131.49794839
31TXK1.47164144
32PRKD31.45880745
33CASK1.39502888
34SIK21.37612108
35MAPK131.37369023
36UHMK11.33032612
37TBK11.31867946
38CDK51.30355858
39SMG11.30033420
40ERBB31.23571659
41JAK21.22141325
42LYN1.21616130
43TRIB31.19983751
44MAP3K141.19672557
45CAMK11.17902195
46MAP3K41.17760141
47RAF11.16514461
48FGR1.16021736
49RIPK11.15951889
50MAP2K61.14889822
51MAP3K11.14074115
52MARK31.12630720
53PTK61.11515189
54SGK21.10333383
55LCK1.07964582
56NTRK11.06876815
57SGK4941.06527465
58SGK2231.06527465
59MAP2K41.05998883
60SIK11.05751046
61DMPK1.04397677
62JAK11.03248350
63SGK31.03200803
64YES11.00414399
65TAOK30.98910438
66TESK20.97515765
67ITK0.96226390
68CSF1R0.90652639
69GRK50.90411790
70BMPR20.88175523
71MAP3K70.87640500
72MARK20.86701778
73IKBKB0.82280189
74STK100.82076315
75IRAK10.82002244
76CAMKK20.81733410
77MUSK0.80631083
78CAMK40.77868697
79IRAK20.77702453
80EPHA30.77180994
81ERN10.76623999
82PTK2B0.76551994
83LRRK20.75861200
84BMX0.74995867
85STK380.74756972
86FGFR40.74498130
87PRKD20.74149482
88PRKCH0.73073252
89PINK10.72645582
90CDK180.69264051
91CDK140.68668466
92CAMK2A0.66810433
93MAP3K20.66708973
94IRAK40.66486681
95DYRK1B0.65378939
96KIT0.64559301
97CDK150.63142609
98FYN0.62934796
99MAP3K60.62811629
100PDK10.62754103
101CDC42BPA0.62663253
102PLK20.62534946
103CDK11A0.62083296
104TEC0.61933742
105STK110.61072922
106PHKG10.60681255
107PHKG20.60681255
108HCK0.60326250
109PRKCG0.58469377
110PIM10.57595737
111TNK20.57122097
112TAOK20.57097765
113MAP3K100.56405650
114PDPK10.56097329
115SGK10.56024766
116SYK0.55478869
117TYRO30.55002210
118BLK0.54395877
119MAP3K50.54321290
120NLK0.52241180
121GRK60.52207212
122HIPK20.51134761
123DAPK30.50007188
124RPS6KC10.49691728
125RPS6KL10.49691728
126BTK0.48970643
127RET0.48841848
128MOS0.48481025
129FGFR30.47379074
130MAP3K80.45958394
131PRKCQ0.45897398
132MAPK120.45753620
133MAPK70.45678346
134MATK0.45649831
135CAMK2B0.45601630
136PTK20.43962703
137CLK10.43070261
138TGFBR20.42525870
139PRKG20.42355391
140ICK0.42258123
141RPS6KA20.42043116
142MAPKAPK20.41792490
143CDK120.41773282
144PRKCZ0.40573601
145DYRK1A0.39934059
146RPS6KA60.39009176
147MAP3K110.38861180
148PKN20.38018110
149CSK0.37830307
150IRAK30.35251530
151IKBKE0.34348939
152ALK0.28721149

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.98007639
2Nicotine addiction_Homo sapiens_hsa050332.61245614
3Synaptic vesicle cycle_Homo sapiens_hsa047212.54640684
4Circadian entrainment_Homo sapiens_hsa047132.50518646
5Long-term potentiation_Homo sapiens_hsa047202.41766164
6Staphylococcus aureus infection_Homo sapiens_hsa051502.28818568
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22494288
8Morphine addiction_Homo sapiens_hsa050322.20854302
9Primary immunodeficiency_Homo sapiens_hsa053402.17386370
10Glutamatergic synapse_Homo sapiens_hsa047242.16977357
11Graft-versus-host disease_Homo sapiens_hsa053322.08046570
12Allograft rejection_Homo sapiens_hsa053302.07088072
13Malaria_Homo sapiens_hsa051442.06151307
14Amphetamine addiction_Homo sapiens_hsa050312.04657921
15GABAergic synapse_Homo sapiens_hsa047272.02585372
16Dopaminergic synapse_Homo sapiens_hsa047281.97294561
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.96432769
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94016191
19Autoimmune thyroid disease_Homo sapiens_hsa053201.93026285
20Salivary secretion_Homo sapiens_hsa049701.91557201
21Cholinergic synapse_Homo sapiens_hsa047251.89165500
22Gastric acid secretion_Homo sapiens_hsa049711.76391417
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76155708
24Measles_Homo sapiens_hsa051621.75349911
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74287489
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70240810
27Oxytocin signaling pathway_Homo sapiens_hsa049211.65448692
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62295686
29Hematopoietic cell lineage_Homo sapiens_hsa046401.61626522
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.61365755
31Insulin secretion_Homo sapiens_hsa049111.58326739
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57667854
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56741283
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56016003
35Cocaine addiction_Homo sapiens_hsa050301.53563232
36Toxoplasmosis_Homo sapiens_hsa051451.50747480
37Renin secretion_Homo sapiens_hsa049241.49792545
38Serotonergic synapse_Homo sapiens_hsa047261.46195437
39Calcium signaling pathway_Homo sapiens_hsa040201.45920853
40Type I diabetes mellitus_Homo sapiens_hsa049401.45840667
41Influenza A_Homo sapiens_hsa051641.43007988
42Long-term depression_Homo sapiens_hsa047301.41953597
43Viral myocarditis_Homo sapiens_hsa054161.40996459
44GnRH signaling pathway_Homo sapiens_hsa049121.39359102
45Antigen processing and presentation_Homo sapiens_hsa046121.39280204
46African trypanosomiasis_Homo sapiens_hsa051431.37559350
47Herpes simplex infection_Homo sapiens_hsa051681.36594839
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.35385305
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34819865
50TNF signaling pathway_Homo sapiens_hsa046681.28002726
51cAMP signaling pathway_Homo sapiens_hsa040241.26226533
52Axon guidance_Homo sapiens_hsa043601.22933039
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22603190
54Glioma_Homo sapiens_hsa052141.22442975
55Phagosome_Homo sapiens_hsa041451.22438993
56Legionellosis_Homo sapiens_hsa051341.21192381
57Taste transduction_Homo sapiens_hsa047421.20663558
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20552161
59Hepatitis B_Homo sapiens_hsa051611.19652870
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.18381146
61Hepatitis C_Homo sapiens_hsa051601.17641554
62Gap junction_Homo sapiens_hsa045401.17613206
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15937971
64VEGF signaling pathway_Homo sapiens_hsa043701.12674553
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11634365
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11362496
67Other glycan degradation_Homo sapiens_hsa005111.04533772
68Apoptosis_Homo sapiens_hsa042101.01188105
69Non-small cell lung cancer_Homo sapiens_hsa052231.00760422
70Renal cell carcinoma_Homo sapiens_hsa052111.00266927
71Chemokine signaling pathway_Homo sapiens_hsa040620.99432475
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99138762
73Melanogenesis_Homo sapiens_hsa049160.98013055
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.97282693
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96085429
76Estrogen signaling pathway_Homo sapiens_hsa049150.96034452
77ErbB signaling pathway_Homo sapiens_hsa040120.94401172
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93460312
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.86904877
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.86103389
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83027056
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82741886
83Pertussis_Homo sapiens_hsa051330.81718742
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.81431513
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81274832
86Rap1 signaling pathway_Homo sapiens_hsa040150.81079295
87MAPK signaling pathway_Homo sapiens_hsa040100.80819038
88Shigellosis_Homo sapiens_hsa051310.79527104
89Type II diabetes mellitus_Homo sapiens_hsa049300.79525713
90Phototransduction_Homo sapiens_hsa047440.79342812
91Endometrial cancer_Homo sapiens_hsa052130.78902081
92Salmonella infection_Homo sapiens_hsa051320.77853572
93Platelet activation_Homo sapiens_hsa046110.77633103
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.77209100
95FoxO signaling pathway_Homo sapiens_hsa040680.77000790
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76915102
97Pancreatic secretion_Homo sapiens_hsa049720.76724237
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76366910
99Dilated cardiomyopathy_Homo sapiens_hsa054140.76278187
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76195109
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75271794
102Viral carcinogenesis_Homo sapiens_hsa052030.74741762
103Epstein-Barr virus infection_Homo sapiens_hsa051690.74386095
104Colorectal cancer_Homo sapiens_hsa052100.74345166
105Endocytosis_Homo sapiens_hsa041440.74211097
106Asthma_Homo sapiens_hsa053100.74195737
107Rheumatoid arthritis_Homo sapiens_hsa053230.70616715
108Collecting duct acid secretion_Homo sapiens_hsa049660.69309730
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68666379
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68474275
111Ras signaling pathway_Homo sapiens_hsa040140.67996540
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66572513
113HTLV-I infection_Homo sapiens_hsa051660.66343009
114Wnt signaling pathway_Homo sapiens_hsa043100.66236580
115mTOR signaling pathway_Homo sapiens_hsa041500.65827885
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64997004
117Choline metabolism in cancer_Homo sapiens_hsa052310.64085215
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63587550
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63250662
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.63199194
121Leishmaniasis_Homo sapiens_hsa051400.62685948
122B cell receptor signaling pathway_Homo sapiens_hsa046620.62030561
123Cardiac muscle contraction_Homo sapiens_hsa042600.61744273
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61727151
125Circadian rhythm_Homo sapiens_hsa047100.60965112
126Amoebiasis_Homo sapiens_hsa051460.60601664
127Vibrio cholerae infection_Homo sapiens_hsa051100.60047111
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59625523
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59365263
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59109107
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.58838396
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58803412
133HIF-1 signaling pathway_Homo sapiens_hsa040660.58084489
134Tuberculosis_Homo sapiens_hsa051520.56812660
135T cell receptor signaling pathway_Homo sapiens_hsa046600.55753950
136Osteoclast differentiation_Homo sapiens_hsa043800.55621347
137Lysosome_Homo sapiens_hsa041420.55477686
138Pancreatic cancer_Homo sapiens_hsa052120.53702856
139Thyroid cancer_Homo sapiens_hsa052160.53312659
140Insulin resistance_Homo sapiens_hsa049310.53217986
141Regulation of autophagy_Homo sapiens_hsa041400.52392862
142Prolactin signaling pathway_Homo sapiens_hsa049170.52035676
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51977105
144Chronic myeloid leukemia_Homo sapiens_hsa052200.48924533
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48360841
146Insulin signaling pathway_Homo sapiens_hsa049100.48198290
147Prostate cancer_Homo sapiens_hsa052150.47342160
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46779398
149Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46729770
150Inositol phosphate metabolism_Homo sapiens_hsa005620.46696872
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44110865
152Notch signaling pathway_Homo sapiens_hsa043300.43821128
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43176676
154Acute myeloid leukemia_Homo sapiens_hsa052210.43020773

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