R3HDML

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)8.39381379
2ganglion development (GO:0061548)7.88027514
3glomerular epithelial cell development (GO:0072310)7.37717384
4positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)6.16393932
5glomerular basement membrane development (GO:0032836)5.73345506
6regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.45505150
7multicellular organismal movement (GO:0050879)5.00720002
8musculoskeletal movement (GO:0050881)5.00720002
9negative regulation of cytosolic calcium ion concentration (GO:0051481)4.93490714
10lens fiber cell development (GO:0070307)4.84862576
11lens development in camera-type eye (GO:0002088)4.76877960
12cerebral cortex neuron differentiation (GO:0021895)4.64314985
13lung secretory cell differentiation (GO:0061140)4.60661346
14glomerulus development (GO:0032835)4.28841085
15embryonic viscerocranium morphogenesis (GO:0048703)4.08507127
16regulation of timing of cell differentiation (GO:0048505)4.06349684
17photoreceptor cell maintenance (GO:0045494)4.02076208
18response to folic acid (GO:0051593)3.91054449
19regulation of development, heterochronic (GO:0040034)3.88404312
20negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.87781829
21prenylation (GO:0097354)3.87028263
22protein prenylation (GO:0018342)3.87028263
23C4-dicarboxylate transport (GO:0015740)3.78140940
24indolalkylamine metabolic process (GO:0006586)3.77581529
25eosinophil chemotaxis (GO:0048245)3.76090426
26epithelial cell differentiation involved in kidney development (GO:0035850)3.72414043
27lens morphogenesis in camera-type eye (GO:0002089)3.68547834
28diterpenoid biosynthetic process (GO:0016102)3.67490799
29behavioral response to ethanol (GO:0048149)3.62886846
30regulation of female gonad development (GO:2000194)3.59553900
31behavioral response to nicotine (GO:0035095)3.57561003
32tryptophan catabolic process (GO:0006569)3.55672888
33indole-containing compound catabolic process (GO:0042436)3.55672888
34indolalkylamine catabolic process (GO:0046218)3.55672888
35cellular ketone body metabolic process (GO:0046950)3.55075673
36epithelial tube branching involved in lung morphogenesis (GO:0060441)3.54384565
37signal peptide processing (GO:0006465)3.52661299
38positive regulation of cAMP-mediated signaling (GO:0043950)3.50730115
39regulation of alkaline phosphatase activity (GO:0010692)3.50321250
40positive regulation of nitric-oxide synthase activity (GO:0051000)3.50300487
41regulation of immunoglobulin secretion (GO:0051023)3.45762440
42reflex (GO:0060004)3.44908660
43lens fiber cell differentiation (GO:0070306)3.43460724
44notochord development (GO:0030903)3.43060632
45response to pheromone (GO:0019236)3.39796995
46metanephric mesenchyme development (GO:0072075)3.39001818
47piRNA metabolic process (GO:0034587)3.38605804
48regulation of cholesterol homeostasis (GO:2000188)3.38574688
49vascular smooth muscle contraction (GO:0014829)3.37485322
50eosinophil migration (GO:0072677)3.34682253
51detection of light stimulus involved in visual perception (GO:0050908)3.34543115
52detection of light stimulus involved in sensory perception (GO:0050962)3.34543115
53axoneme assembly (GO:0035082)3.33560227
54sympathetic nervous system development (GO:0048485)3.32407861
55regulation of phospholipid biosynthetic process (GO:0071071)3.27768415
56kidney mesenchyme development (GO:0072074)3.26007922
57negative regulation of potassium ion transmembrane transport (GO:1901380)3.25817572
58regulation of endothelial cell chemotaxis (GO:2001026)3.22553554
59endothelial cell morphogenesis (GO:0001886)3.21381387
60cilium or flagellum-dependent cell motility (GO:0001539)3.20979229
61ketone body metabolic process (GO:1902224)3.19304201
62histone H2A acetylation (GO:0043968)3.18150862
63establishment of integrated proviral latency (GO:0075713)3.16902488
64nonmotile primary cilium assembly (GO:0035058)3.16114205
65regulation of regulatory T cell differentiation (GO:0045589)3.15013642
66detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14479082
67multicellular organism reproduction (GO:0032504)3.11862790
68embryonic skeletal joint morphogenesis (GO:0060272)3.08750348
69inositol phosphate catabolic process (GO:0071545)3.08062004
70positive regulation of interleukin-17 production (GO:0032740)3.06568011
71neural tube formation (GO:0001841)3.05955956
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03579244
73regulation of cilium movement (GO:0003352)3.03410799
74lung vasculature development (GO:0060426)3.01624785
75negative regulation of B cell apoptotic process (GO:0002903)3.00642436
76tryptophan metabolic process (GO:0006568)3.00208676
77paraxial mesoderm development (GO:0048339)3.00068525
78regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.99210846
79hepatocyte apoptotic process (GO:0097284)2.98676148
80epithelial cilium movement (GO:0003351)2.98485657
81wound healing, spreading of cells (GO:0044319)2.95007859
82cell adhesion mediated by integrin (GO:0033627)2.94558592
83neuroblast proliferation (GO:0007405)2.94047329
84limb bud formation (GO:0060174)2.93711905
85positive regulation of fatty acid transport (GO:2000193)2.93496824
86endothelial cell chemotaxis (GO:0035767)2.92342823
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92070735
88response to lithium ion (GO:0010226)2.91495298
89oligodendrocyte development (GO:0014003)2.90509157
90intraciliary transport (GO:0042073)2.90117264
91cilium morphogenesis (GO:0060271)2.89173774
92ubiquinone biosynthetic process (GO:0006744)2.89048391
93positive regulation of p38MAPK cascade (GO:1900745)2.88515634
94L-fucose metabolic process (GO:0042354)2.87497778
95L-fucose catabolic process (GO:0042355)2.87497778
96fucose catabolic process (GO:0019317)2.87497778
97auditory receptor cell differentiation (GO:0042491)2.87416765
98G-protein coupled receptor internalization (GO:0002031)2.86992840
99neural crest cell development (GO:0014032)2.86164054
100cellular biogenic amine catabolic process (GO:0042402)2.85446618
101amine catabolic process (GO:0009310)2.85446618
102fibrinolysis (GO:0042730)2.84787915
103proline transport (GO:0015824)2.84140145
104S-adenosylmethionine metabolic process (GO:0046500)2.81455703
105platelet dense granule organization (GO:0060155)2.81368502
106negative regulation of complement activation (GO:0045916)2.80552946
107positive regulation of cell adhesion mediated by integrin (GO:0033630)2.78775735
108coronary vasculature morphogenesis (GO:0060977)2.78521060
109negative regulation of protein activation cascade (GO:2000258)2.78518032
110glandular epithelial cell differentiation (GO:0002067)2.78350247
111erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.77676645
112L-phenylalanine catabolic process (GO:0006559)2.77676645
113signal complex assembly (GO:0007172)2.77388359
114L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77093734
115establishment of protein localization to Golgi (GO:0072600)2.76870953
116quinone biosynthetic process (GO:1901663)2.76111272
117transepithelial transport (GO:0070633)2.75898311
118glial cell proliferation (GO:0014009)2.75652973
119muscle cell fate commitment (GO:0042693)2.75644482
120positive regulation of cartilage development (GO:0061036)2.75045120
121muscle cell migration (GO:0014812)2.74968015
122cilium movement (GO:0003341)2.73115441
123wound healing, spreading of epidermal cells (GO:0035313)2.72653999
124protein kinase C signaling (GO:0070528)2.71662373
125kidney morphogenesis (GO:0060993)2.71095074
126forebrain neuron differentiation (GO:0021879)2.70147822
127DNA deamination (GO:0045006)2.69837229
128cilium organization (GO:0044782)2.68842464
129cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.68835378
130positive regulation of chondrocyte differentiation (GO:0032332)2.67102122
131regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66758182
132cilium assembly (GO:0042384)2.64574411
133embryonic camera-type eye development (GO:0031076)2.64529221
134opioid receptor signaling pathway (GO:0038003)2.64218356
135regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.62799538
136lymph vessel development (GO:0001945)2.62254272
137regulation of acrosome reaction (GO:0060046)2.62181617
138protein retention in ER lumen (GO:0006621)2.62094903
139terpenoid biosynthetic process (GO:0016114)2.61530666
140water-soluble vitamin biosynthetic process (GO:0042364)2.61254259
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.60285370
142L-phenylalanine metabolic process (GO:0006558)2.60285370
143L-methionine salvage (GO:0071267)2.59756407
144L-methionine biosynthetic process (GO:0071265)2.59756407
145amino acid salvage (GO:0043102)2.59756407
146positive regulation of neural precursor cell proliferation (GO:2000179)2.59209734
147histone mRNA catabolic process (GO:0071044)2.57951927
148ncRNA catabolic process (GO:0034661)2.57331620
149organ induction (GO:0001759)2.57135637
150polyol catabolic process (GO:0046174)2.56922363
151dendritic spine morphogenesis (GO:0060997)2.56491557
152kynurenine metabolic process (GO:0070189)2.56256514
153fatty acid transmembrane transport (GO:1902001)2.56221628
154aromatic amino acid family catabolic process (GO:0009074)2.55241233
155negative regulation of homotypic cell-cell adhesion (GO:0034111)2.54261000
156ovulation cycle (GO:0042698)2.54194098
157regulation of bile acid biosynthetic process (GO:0070857)2.54186192
158regulation of extracellular matrix disassembly (GO:0010715)2.53943687
159bile acid and bile salt transport (GO:0015721)2.53466993
160regulation of isotype switching to IgG isotypes (GO:0048302)2.53108638
161regulation of secondary heart field cardioblast proliferation (GO:0003266)2.52495424
162regulation of cardioblast proliferation (GO:0003264)2.52495424
163lung cell differentiation (GO:0060479)2.51279489
164myoblast fusion (GO:0007520)2.49928846
165response to epidermal growth factor (GO:0070849)2.49919398
166indole-containing compound metabolic process (GO:0042430)2.49409246
167endocardial cushion development (GO:0003197)2.48875704
168DNA demethylation (GO:0080111)2.48830265
169negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48825826
170sperm motility (GO:0030317)2.46974305
171ventricular cardiac muscle cell action potential (GO:0086005)2.46812963
172protein targeting to Golgi (GO:0000042)2.46592481
173retinal metabolic process (GO:0042574)2.45878228
174regulation of p38MAPK cascade (GO:1900744)2.45124247
175ubiquinone metabolic process (GO:0006743)2.44838669
176protein localization to Golgi apparatus (GO:0034067)2.44615738
177lung epithelial cell differentiation (GO:0060487)2.44586429
178heart valve morphogenesis (GO:0003179)2.43928540
179negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.43697011
180positive regulation of catenin import into nucleus (GO:0035413)2.42397947
181tachykinin receptor signaling pathway (GO:0007217)2.42303338
182positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.42027593
183photoreceptor cell development (GO:0042461)2.42020148
184hair cell differentiation (GO:0035315)2.42008498
185carnitine shuttle (GO:0006853)2.41491037
186nucleobase catabolic process (GO:0046113)2.41288004
187cell aggregation (GO:0098743)2.41259570
188cartilage condensation (GO:0001502)2.41259570
189neuronal action potential (GO:0019228)2.41218250
190positive regulation of glycolytic process (GO:0045821)2.40856615
191preassembly of GPI anchor in ER membrane (GO:0016254)2.40071930
192spinal cord association neuron differentiation (GO:0021527)2.39989140
193pyrimidine nucleobase catabolic process (GO:0006208)2.39787805
194calcium ion import (GO:0070509)2.39655505
195acrosome reaction (GO:0007340)2.39629885
196regulation of memory T cell differentiation (GO:0043380)2.39513075
197adult feeding behavior (GO:0008343)2.39388345
198neuron fate specification (GO:0048665)2.38841947
199myoblast migration (GO:0051451)2.38795019
200regulation of plasminogen activation (GO:0010755)2.37266972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.47809403
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.13734187
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.69536441
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.66519057
5GBX2_23144817_ChIP-Seq_PC3_Human3.62345421
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.53745986
7ZNF274_21170338_ChIP-Seq_K562_Hela3.50313412
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.91728672
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87316595
10VDR_22108803_ChIP-Seq_LS180_Human2.76370525
11CLOCK_20551151_ChIP-Seq_293T_Human2.76101292
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.74268315
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.69255609
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.62882291
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.57388505
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.57388505
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.57388505
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50407870
19TAF15_26573619_Chip-Seq_HEK293_Human2.47521541
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.38026039
21IGF1R_20145208_ChIP-Seq_DFB_Human2.36929861
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.35185727
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31469811
24PPARA_22158963_ChIP-Seq_LIVER_Mouse2.29791415
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22659100
26FUS_26573619_Chip-Seq_HEK293_Human2.19578390
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19155142
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17528432
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.09795043
30ESR2_21235772_ChIP-Seq_MCF-7_Human2.08285349
31LXR_22158963_ChIP-Seq_LIVER_Mouse2.07032635
32ER_23166858_ChIP-Seq_MCF-7_Human2.05599741
33P300_19829295_ChIP-Seq_ESCs_Human2.04150017
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03745998
35PPAR_26484153_Chip-Seq_NCI-H1993_Human2.01510877
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.99719551
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.96045707
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.93350442
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86812154
40EWS_26573619_Chip-Seq_HEK293_Human1.85463281
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80658594
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80053027
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74743467
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.74487465
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.72414275
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71191054
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70965273
48CBP_20019798_ChIP-Seq_JUKART_Human1.69808816
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69808816
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.68893185
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67904597
52SMAD4_21799915_ChIP-Seq_A2780_Human1.67892135
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64482698
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61328139
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60987829
56STAT3_23295773_ChIP-Seq_U87_Human1.60622546
57CJUN_26792858_Chip-Seq_BT549_Human1.58387635
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57683787
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.56366455
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55131584
61SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54883967
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.53443301
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53061923
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53061923
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52541395
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51626352
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51544367
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51312007
69TCF4_23295773_ChIP-Seq_U87_Human1.50965620
70TP53_22573176_ChIP-Seq_HFKS_Human1.46115161
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44601782
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43237715
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43125267
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.42784862
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41913114
76NANOG_19829295_ChIP-Seq_ESCs_Human1.41294078
77SOX2_19829295_ChIP-Seq_ESCs_Human1.41294078
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40108523
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39821025
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39562851
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38096124
82TCF4_22108803_ChIP-Seq_LS180_Human1.38089399
83EZH2_22144423_ChIP-Seq_EOC_Human1.37629044
84AR_25329375_ChIP-Seq_VCAP_Human1.37485839
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37211889
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36256936
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35992563
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35860074
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34718667
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.34672342
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.34117332
92HTT_18923047_ChIP-ChIP_STHdh_Human1.33845069
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.31929627
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31693955
95* CDX2_20551321_ChIP-Seq_CACO-2_Human1.30882735
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30459395
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29013703
98SOX2_20726797_ChIP-Seq_SW620_Human1.28166960
99RUNX2_22187159_ChIP-Seq_PCA_Human1.27869056
100EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27633439
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27633439
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27548006
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27353826
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26147740
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25578344
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25279112
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25279112
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24977738
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.24189731
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24178693
111FOXA2_19822575_ChIP-Seq_HepG2_Human1.24069434
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.22908076
113RUNX1_27514584_Chip-Seq_MCF-7_Human1.21781665
114CDX2_22108803_ChIP-Seq_LS180_Human1.20599104
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20349429
116WDR5_24793694_ChIP-Seq_LNCAP_Human1.20291697
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20186156
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.19144778
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18994106
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17656182
121FOXO3_23340844_ChIP-Seq_DLD1_Human1.17073906
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16130770
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16130770
124EGR1_19032775_ChIP-ChIP_M12_Human1.14948196
125P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13974936
126FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12506530
127CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12050910
128TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11924403
129NOTCH1_21737748_ChIP-Seq_TLL_Human1.11079494
130AR_21909140_ChIP-Seq_LNCAP_Human1.10172417
131GATA2_21666600_ChIP-Seq_HMVEC_Human1.09949660
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.09173683
133PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08815875
134FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07188257
135TP53_16413492_ChIP-PET_HCT116_Human1.06877470
136GATA3_21878914_ChIP-Seq_MCF-7_Human1.06768833
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06751588
138SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06503283
139SALL1_21062744_ChIP-ChIP_HESCs_Human1.06262216
140TBX20_22328084_ChIP-Seq_HEART_Mouse1.05950469
141TBX20_22080862_ChIP-Seq_HEART_Mouse1.05950469
142FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05511137
143FOXA1_25329375_ChIP-Seq_VCAP_Human1.05511137
144KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05199028
145RNF2_27304074_Chip-Seq_ESCs_Mouse1.05168711
146NCOR_22424771_ChIP-Seq_293T_Human1.04628783
147SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04427843
148RXR_22108803_ChIP-Seq_LS180_Human1.03880021
149JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03381820
150WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03194460
151FLI1_21867929_ChIP-Seq_TH2_Mouse1.03173688
152TP53_18474530_ChIP-ChIP_U2OS_Human1.03040118
153SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02315337
154TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01564772
155OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01045379
156GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00816427
157TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00712478
158EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00189415
159RING1B_27294783_Chip-Seq_NPCs_Mouse0.99983851
160AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98934482
161CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98630383
162KDM2B_26808549_Chip-Seq_REH_Human0.98070258
163SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97810548
164ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97314291
165RNF2_27304074_Chip-Seq_NSC_Mouse0.96907995
166PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96898611
167NANOG_18692474_ChIP-Seq_MEFs_Mouse0.96842434
168ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96498940
169HOXB7_26014856_ChIP-Seq_BT474_Human0.96421059
170SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96060620
171RACK7_27058665_Chip-Seq_MCF-7_Human0.95450072
172NANOG_18555785_Chip-Seq_ESCs_Mouse0.95335610
173GATA4_25053715_ChIP-Seq_YYC3_Human0.95161978
174GATA3_24758297_ChIP-Seq_MCF-7_Human0.94282193
175CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93719846
176TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92398830
177PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92176654
178NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88997429
179SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88476239
180SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.87979931
181ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85961551
182KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85866412
183STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84904952
184SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.83110081
185KDM2B_26808549_Chip-Seq_K562_Human0.82913232
186PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.82667529
187BCAT_22108803_ChIP-Seq_LS180_Human0.82046374
188PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81718698
189RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80540485
190SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80402004
191POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80097118
192TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78367364

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog3.24741065
2MP0002877_abnormal_melanocyte_morpholog3.23549442
3MP0003880_abnormal_central_pattern3.17674735
4MP0002139_abnormal_hepatobiliary_system3.17646056
5MP0002697_abnormal_eye_size3.12854147
6MP0000537_abnormal_urethra_morphology3.06904650
7MP0010368_abnormal_lymphatic_system3.06821617
8MP0008789_abnormal_olfactory_epithelium2.96785094
9MP0005623_abnormal_meninges_morphology2.95243470
10MP0010030_abnormal_orbit_morphology2.86872894
11MP0001968_abnormal_touch/_nociception2.74398502
12MP0005360_urolithiasis2.73853201
13MP0002736_abnormal_nociception_after2.64131752
14MP0005503_abnormal_tendon_morphology2.55058170
15MP0003283_abnormal_digestive_organ2.52591225
16MP0005423_abnormal_somatic_nervous2.42566166
17MP0005193_abnormal_anterior_eye2.38444603
18MP0005085_abnormal_gallbladder_physiolo2.33787301
19MP0000383_abnormal_hair_follicle2.31095648
20MP0003718_maternal_effect2.27452061
21MP0001986_abnormal_taste_sensitivity2.26262725
22MP0005646_abnormal_pituitary_gland2.18624584
23MP0003705_abnormal_hypodermis_morpholog2.17757322
24MP0001501_abnormal_sleep_pattern2.13128795
25MP0003195_calcinosis2.07890713
26MP0005248_abnormal_Harderian_gland2.03884234
27MP0000516_abnormal_urinary_system1.98667978
28MP0005367_renal/urinary_system_phenotyp1.98667978
29MP0006072_abnormal_retinal_apoptosis1.98416846
30MP0008872_abnormal_physiological_respon1.95917982
31MP0003787_abnormal_imprinting1.93720327
32MP0005499_abnormal_olfactory_system1.91303907
33MP0005394_taste/olfaction_phenotype1.91303907
34MP0006292_abnormal_olfactory_placode1.90594909
35MP0005451_abnormal_body_composition1.87796265
36MP0010234_abnormal_vibrissa_follicle1.87338643
37MP0001879_abnormal_lymphatic_vessel1.86246115
38MP0001346_abnormal_lacrimal_gland1.85503043
39MP0003252_abnormal_bile_duct1.84647116
40MP0004272_abnormal_basement_membrane1.84415521
41MP0002876_abnormal_thyroid_physiology1.83070509
42MP0008875_abnormal_xenobiotic_pharmacok1.82902902
43MP0002102_abnormal_ear_morphology1.81977897
44MP0001485_abnormal_pinna_reflex1.81602829
45MP0001286_abnormal_eye_development1.77152999
46MP0000372_irregular_coat_pigmentation1.76434006
47MP0002163_abnormal_gland_morphology1.76429849
48MP0001486_abnormal_startle_reflex1.73630124
49MP0008877_abnormal_DNA_methylation1.68885662
50MP0005197_abnormal_uvea_morphology1.67203669
51MP0009250_abnormal_appendicular_skeleto1.64363243
52MP0003315_abnormal_perineum_morphology1.63914996
53MP0009046_muscle_twitch1.60889493
54MP0003119_abnormal_digestive_system1.59932072
55MP0010678_abnormal_skin_adnexa1.59309259
56MP0004145_abnormal_muscle_electrophysio1.58414083
57MP0008438_abnormal_cutaneous_collagen1.56877160
58MP0001853_heart_inflammation1.52579412
59MP0002282_abnormal_trachea_morphology1.51912065
60MP0005379_endocrine/exocrine_gland_phen1.51597120
61MP0005395_other_phenotype1.50039416
62MP0006054_spinal_hemorrhage1.47835883
63MP0002938_white_spotting1.46860444
64MP0008775_abnormal_heart_ventricle1.43978992
65MP0002272_abnormal_nervous_system1.42441481
66MP0005253_abnormal_eye_physiology1.41067888
67MP0000015_abnormal_ear_pigmentation1.37765194
68MP0009053_abnormal_anal_canal1.37616741
69MP0002138_abnormal_hepatobiliary_system1.37023249
70MP0005084_abnormal_gallbladder_morpholo1.34978819
71MP0000534_abnormal_ureter_morphology1.33797973
72MP0001299_abnormal_eye_distance/1.33571441
73MP0005332_abnormal_amino_acid1.32410303
74MP0003942_abnormal_urinary_system1.32197985
75MP0009384_cardiac_valve_regurgitation1.32131964
76MP0006276_abnormal_autonomic_nervous1.29447831
77MP0000749_muscle_degeneration1.28985371
78MP0000427_abnormal_hair_cycle1.27502985
79MP0005365_abnormal_bile_salt1.27171000
80MP0002092_abnormal_eye_morphology1.26870054
81MP0001542_abnormal_bone_strength1.25997790
82MP0002233_abnormal_nose_morphology1.24921463
83MP0004742_abnormal_vestibular_system1.23724202
84MP0009780_abnormal_chondrocyte_physiolo1.22269358
85MP0001529_abnormal_vocalization1.21836661
86MP0002269_muscular_atrophy1.20909869
87MP0000631_abnormal_neuroendocrine_gland1.20338281
88MP0001764_abnormal_homeostasis1.20037068
89MP0005410_abnormal_fertilization1.19271167
90MP0009745_abnormal_behavioral_response1.18721844
91MP0004084_abnormal_cardiac_muscle1.18486130
92MP0000733_abnormal_muscle_development1.16567908
93MP0003937_abnormal_limbs/digits/tail_de1.15814346
94MP0003385_abnormal_body_wall1.14695548
95MP0004264_abnormal_extraembryonic_tissu1.14088443
96MP0002932_abnormal_joint_morphology1.14028432
97MP0000465_gastrointestinal_hemorrhage1.13730193
98MP0003806_abnormal_nucleotide_metabolis1.12735732
99MP0001915_intracranial_hemorrhage1.12396737
100MP0004885_abnormal_endolymph1.11317990
101MP0004782_abnormal_surfactant_physiolog1.10642069
102MP0000579_abnormal_nail_morphology1.07528240
103MP0004924_abnormal_behavior1.06037322
104MP0005386_behavior/neurological_phenoty1.06037322
105MP0002234_abnormal_pharynx_morphology1.02972885
106MP0000163_abnormal_cartilage_morphology1.02030014
107MP0002249_abnormal_larynx_morphology1.01939078
108MP0005508_abnormal_skeleton_morphology0.97329631
109MP0001324_abnormal_eye_pigmentation0.94934234
110MP0003091_abnormal_cell_migration0.94900998
111MP0005174_abnormal_tail_pigmentation0.94139246
112MP0001835_abnormal_antigen_presentation0.93904065
113MP0005408_hypopigmentation0.93269895
114MP0003567_abnormal_fetal_cardiomyocyte0.92615098
115MP0001666_abnormal_nutrient_absorption0.92020655
116MP0002115_abnormal_skeleton_extremities0.91812248
117MP0002090_abnormal_vision0.91141484
118MP0002108_abnormal_muscle_morphology0.89658570
119MP0005636_abnormal_mineral_homeostasis0.89636482
120MP0000569_abnormal_digit_pigmentation0.89441669
121MP0005195_abnormal_posterior_eye0.89341643
122MP0003115_abnormal_respiratory_system0.89315428
123MP0002735_abnormal_chemical_nociception0.89043473
124MP0005645_abnormal_hypothalamus_physiol0.88444236
125MP0009697_abnormal_copulation0.88141291
126MP0002168_other_aberrant_phenotype0.87997538
127MP0002734_abnormal_mechanical_nocicepti0.87913676
128MP0004019_abnormal_vitamin_homeostasis0.87558535
129MP0000604_amyloidosis0.87050117
130MP0000858_altered_metastatic_potential0.85666859
131MP0002095_abnormal_skin_pigmentation0.85566092
132MP0002909_abnormal_adrenal_gland0.82485830
133MP0003938_abnormal_ear_development0.82411572
134MP0002837_dystrophic_cardiac_calcinosis0.82019164
135MP0000230_abnormal_systemic_arterial0.81563702
136MP0005187_abnormal_penis_morphology0.81538908
137MP0003566_abnormal_cell_adhesion0.81199945
138MP0000751_myopathy0.80942044
139MP0003123_paternal_imprinting0.80865291
140MP0003646_muscle_fatigue0.80643412
141MP0002064_seizures0.79806188
142MP0002229_neurodegeneration0.78723346
143MP0003941_abnormal_skin_development0.78185119
144MP0000647_abnormal_sebaceous_gland0.77539560
145MP0009643_abnormal_urine_homeostasis0.77244365
146MP0002295_abnormal_pulmonary_circulatio0.76477218
147MP0002693_abnormal_pancreas_physiology0.76443481
148MP0001970_abnormal_pain_threshold0.75747252
149MP0002277_abnormal_respiratory_mucosa0.75588303
150MP0010329_abnormal_lipoprotein_level0.75556892
151MP0002751_abnormal_autonomic_nervous0.74827498
152MP0001756_abnormal_urination0.74140963
153MP0004133_heterotaxia0.72377425
154MP0003950_abnormal_plasma_membrane0.72333754
155MP0002896_abnormal_bone_mineralization0.72304040
156MP0005391_vision/eye_phenotype0.72047087
157MP0002933_joint_inflammation0.71354024
158MP0000049_abnormal_middle_ear0.71162657
159MP0005275_abnormal_skin_tensile0.70869133
160MP0001340_abnormal_eyelid_morphology0.70402509
161MP0005023_abnormal_wound_healing0.69393278
162MP0001984_abnormal_olfaction0.68787739
163MP0002109_abnormal_limb_morphology0.67279565
164MP0004134_abnormal_chest_morphology0.66538291
165MP0009840_abnormal_foam_cell0.65995546
166MP0004036_abnormal_muscle_relaxation0.65020308
167MP0003453_abnormal_keratinocyte_physiol0.64893139

Predicted human phenotypes

RankGene SetZ-score
1Nuclear cataract (HP:0100018)9.70783887
2Zonular cataract (HP:0010920)8.62653800
3True hermaphroditism (HP:0010459)4.31828452
4Focal segmental glomerulosclerosis (HP:0000097)4.21533134
5Aplasia of the musculature (HP:0100854)4.07736271
6Pancreatic cysts (HP:0001737)4.06314277
7Pancreatic fibrosis (HP:0100732)3.85603670
8Abnormal rod and cone electroretinograms (HP:0008323)3.82789101
9Abnormality of midbrain morphology (HP:0002418)3.71143375
10Molar tooth sign on MRI (HP:0002419)3.71143375
11Type II lissencephaly (HP:0007260)3.66243887
12Deep venous thrombosis (HP:0002625)3.65696064
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.60459361
14Tongue fasciculations (HP:0001308)3.54884770
15Glomerulosclerosis (HP:0000096)3.47142625
16Abnormal tarsal ossification (HP:0008369)3.44832571
17Spinal muscular atrophy (HP:0007269)3.43951966
18Muscle fibrillation (HP:0010546)3.43661559
19Medial flaring of the eyebrow (HP:0010747)3.28455905
20Metaphyseal cupping (HP:0003021)3.25074538
21Congenital stationary night blindness (HP:0007642)3.18817064
22Metaphyseal dysplasia (HP:0100255)3.15617972
23Attenuation of retinal blood vessels (HP:0007843)3.14522450
24Nephronophthisis (HP:0000090)3.09819423
25Absent phalangeal crease (HP:0006109)2.99742608
26Broad-based gait (HP:0002136)2.99191506
27Tubular atrophy (HP:0000092)2.95180319
28Mesangial abnormality (HP:0001966)2.93816180
29Pendular nystagmus (HP:0012043)2.93284802
30Intestinal atresia (HP:0011100)2.92899555
31Anterior segment dysgenesis (HP:0007700)2.90723300
32Abnormality of the renal cortex (HP:0011035)2.90197048
33Chronic hepatic failure (HP:0100626)2.90135251
34Cerebellar dysplasia (HP:0007033)2.88638860
35Decreased central vision (HP:0007663)2.87497347
36Aplasia/Hypoplasia involving the musculature (HP:0001460)2.86052883
37Congenital cataract (HP:0000519)2.85793398
38Renal cortical cysts (HP:0000803)2.85545259
39Cystic liver disease (HP:0006706)2.80671013
40Thyroid-stimulating hormone excess (HP:0002925)2.79214497
41Increased corneal curvature (HP:0100692)2.78628882
42Keratoconus (HP:0000563)2.78628882
43Polar cataract (HP:0010696)2.76351466
44Gaze-evoked nystagmus (HP:0000640)2.73083091
45Pterygium (HP:0001059)2.69711566
46Fetal akinesia sequence (HP:0001989)2.68728468
47Severe visual impairment (HP:0001141)2.66551443
48Delayed epiphyseal ossification (HP:0002663)2.65991706
49Abnormality of the renal medulla (HP:0100957)2.65827779
50Popliteal pterygium (HP:0009756)2.65733241
51Abnormality of placental membranes (HP:0011409)2.60672399
52Amniotic constriction ring (HP:0009775)2.60672399
53Exercise-induced muscle cramps (HP:0003710)2.56993154
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.55735005
55Congenital primary aphakia (HP:0007707)2.54848187
56Focal motor seizures (HP:0011153)2.54030559
57Neonatal respiratory distress (HP:0002643)2.52030246
58Polydipsia (HP:0001959)2.51699558
59Abnormal drinking behavior (HP:0030082)2.51699558
60Gait imbalance (HP:0002141)2.51473718
61Abnormal finger flexion creases (HP:0006143)2.51146608
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.49321807
63Gowers sign (HP:0003391)2.48676048
64Limited hip movement (HP:0008800)2.46398680
65Aplasia involving bones of the extremities (HP:0009825)2.43619174
66Aplasia involving bones of the upper limbs (HP:0009823)2.43619174
67Aplasia of the phalanges of the hand (HP:0009802)2.43619174
68Chronic mucocutaneous candidiasis (HP:0002728)2.43538131
69Recurrent cutaneous fungal infections (HP:0011370)2.43538131
70Nephrogenic diabetes insipidus (HP:0009806)2.42380458
71Vitreoretinal degeneration (HP:0000655)2.42189976
72Hip contracture (HP:0003273)2.41626765
73Hypoventilation (HP:0002791)2.38370628
74Thin ribs (HP:0000883)2.38051262
75Epiphyseal dysplasia (HP:0002656)2.36264482
76Retinal dysplasia (HP:0007973)2.34196326
77Degeneration of anterior horn cells (HP:0002398)2.32712529
78Abnormality of the anterior horn cell (HP:0006802)2.32712529
79Abnormality of the 2nd finger (HP:0004100)2.32489868
80Short hallux (HP:0010109)2.32023259
81Intrahepatic cholestasis (HP:0001406)2.31711388
82Polyuria (HP:0000103)2.31076595
83Abnormal ciliary motility (HP:0012262)2.30603566
84Methylmalonic acidemia (HP:0002912)2.29888740
85Inability to walk (HP:0002540)2.29632144
86Progressive inability to walk (HP:0002505)2.28947434
87Disproportionate short-trunk short stature (HP:0003521)2.28076115
88Hemiparesis (HP:0001269)2.26645827
89Lissencephaly (HP:0001339)2.26546116
90Progressive cerebellar ataxia (HP:0002073)2.25827842
91Nonprogressive disorder (HP:0003680)2.25260394
92Hypoalbuminemia (HP:0003073)2.24911302
93Abnormal albumin level (HP:0012116)2.24911302
94Nephritis (HP:0000123)2.24550239
95Abolished electroretinogram (ERG) (HP:0000550)2.23267248
96Aplasia/Hypoplasia of the hallux (HP:0008362)2.21781700
97Abnormality of the phalanges of the 2nd finger (HP:0009541)2.18653854
98Absent speech (HP:0001344)2.18357075
99Pancreatic islet-cell hyperplasia (HP:0004510)2.18095658
100Abnormality of the proximal phalanges of the hand (HP:0009834)2.16816919
101Bony spicule pigmentary retinopathy (HP:0007737)2.16209140
102Symphalangism affecting the phalanges of the hand (HP:0009773)2.15216127
103Constricted visual fields (HP:0001133)2.14353988
104Optic nerve hypoplasia (HP:0000609)2.14159797
105Hypoplastic heart (HP:0001961)2.13455958
106Skin nodule (HP:0200036)2.13178057
107Aortic aneurysm (HP:0004942)2.12580112
108Abnormal foot bone ossification (HP:0010675)2.11423356
109Anencephaly (HP:0002323)2.10635081
110Carpal bone hypoplasia (HP:0001498)2.10115951
111Glomerulonephritis (HP:0000099)2.09133828
112Hyperglycinemia (HP:0002154)2.09091335
113Abnormality of the middle phalanges of the toes (HP:0010183)2.09080577
114Hip dysplasia (HP:0001385)2.08899261
115Glycosuria (HP:0003076)2.08289725
116Abnormality of urine glucose concentration (HP:0011016)2.08289725
117Pigmentary retinal degeneration (HP:0001146)2.07837713
118Hyperglycinuria (HP:0003108)2.06966591
119Right ventricular cardiomyopathy (HP:0011663)2.06767216
120Male pseudohermaphroditism (HP:0000037)2.06551973
121Amblyopia (HP:0000646)2.06315221
122Bile duct proliferation (HP:0001408)2.04785072
123Abnormal biliary tract physiology (HP:0012439)2.04785072
124Febrile seizures (HP:0002373)2.04379027
125Hypothermia (HP:0002045)2.03952379
126Hyperventilation (HP:0002883)2.03257901
127Abnormal respiratory epithelium morphology (HP:0012253)2.03165667
128Abnormal respiratory motile cilium morphology (HP:0005938)2.03165667
129Methylmalonic aciduria (HP:0012120)2.03121195
130Xanthomatosis (HP:0000991)2.02148322
131Flat capital femoral epiphysis (HP:0003370)2.01689563
132Postaxial foot polydactyly (HP:0001830)1.99228768
133Congenital, generalized hypertrichosis (HP:0004540)1.99211472
134Occipital encephalocele (HP:0002085)1.98996064
135Germ cell neoplasia (HP:0100728)1.98877851
136Short tibia (HP:0005736)1.97848065
137Flat acetabular roof (HP:0003180)1.97771903
138Stomatitis (HP:0010280)1.97600059
139Congenital hepatic fibrosis (HP:0002612)1.97587940
140Abnormality of carpal bone ossification (HP:0006257)1.97473192
141Genital tract atresia (HP:0001827)1.95305387
142Vaginal atresia (HP:0000148)1.94989063
143Abnormality of monocarboxylic acid metabolism (HP:0010996)1.94608595
144Corneal dystrophy (HP:0001131)1.93985498
145Cupped ribs (HP:0000887)1.93572708
146Abnormal urine output (HP:0012590)1.92740488
147Lymphangioma (HP:0100764)1.92646779
148Congenital sensorineural hearing impairment (HP:0008527)1.92279631
149Exostoses (HP:0100777)1.91975817
150Postaxial hand polydactyly (HP:0001162)1.91244362
151Horizontal nystagmus (HP:0000666)1.89966566
152Abnormality of glycine metabolism (HP:0010895)1.89791182
153Abnormality of serine family amino acid metabolism (HP:0010894)1.89791182
154Furrowed tongue (HP:0000221)1.89740528
155Abnormality of the intrinsic pathway (HP:0010989)1.87071949
156Vertebral clefting (HP:0008428)1.86178463
157Back pain (HP:0003418)1.86106379
158Sclerocornea (HP:0000647)1.85180963
159Abnormal respiratory motile cilium physiology (HP:0012261)1.84849558
160Abnormality of glutamine family amino acid metabolism (HP:0010902)1.84070838
161Astigmatism (HP:0000483)1.83555373
162Epidermoid cyst (HP:0200040)1.82304617
163Abnormality of alanine metabolism (HP:0010916)1.81752929
164Hyperalaninemia (HP:0003348)1.81752929
165Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81752929
166Abnormality of the distal phalanges of the toes (HP:0010182)1.80374171
167Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80053523
168Fused cervical vertebrae (HP:0002949)1.79847210
169Median cleft lip (HP:0000161)1.79533795
170Distal arthrogryposis (HP:0005684)1.79235543
171Biliary tract neoplasm (HP:0100574)1.78894249
172Abnormality of macular pigmentation (HP:0008002)1.78892376
173Optic disc pallor (HP:0000543)1.78560762
174Protrusio acetabuli (HP:0003179)1.78151282
175Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.76859100
176Tented upper lip vermilion (HP:0010804)1.76797328
177Vascular calcification (HP:0004934)1.75706288
178Cardiovascular calcification (HP:0011915)1.75051787
179Overgrowth (HP:0001548)1.74729681
180Tarsal synostosis (HP:0008368)1.74589146
181Spontaneous abortion (HP:0005268)1.73800914
182Irregular epiphyses (HP:0010582)1.72509392
183Exercise-induced myalgia (HP:0003738)1.72453765
184Tubulointerstitial fibrosis (HP:0005576)1.71816061
185Abnormality of proline metabolism (HP:0010907)1.71168042
186Hydroxyprolinuria (HP:0003080)1.71168042
187Abnormality of the 1st metacarpal (HP:0010009)1.70774369
188Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.69494558
189Short 1st metacarpal (HP:0010034)1.69494558
190Hypoplastic ischia (HP:0003175)1.68333458
191Nemaline bodies (HP:0003798)1.67859713
192Abnormalities of placenta or umbilical cord (HP:0001194)1.67555864
193Prolonged partial thromboplastin time (HP:0003645)1.66643512
194Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.66202146
195Muscle fiber splitting (HP:0003555)1.66124337
196Breast hypoplasia (HP:0003187)1.66055182
197Knee flexion contracture (HP:0006380)1.65737985
198Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64466259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.44865793
2EPHA24.32283065
3ZAK4.19124117
4CDC74.16869089
5BMPR23.81771716
6LATS13.64739676
7LATS23.55746826
8EPHB23.40003677
9ADRBK23.05966255
10MOS3.01181215
11STK38L2.65461070
12WNK32.39095928
13MAP4K22.32868730
14EPHA32.27974251
15MAP3K42.24547992
16ERBB32.13318272
17MUSK2.04703174
18FER1.98285600
19PAK41.94918042
20TRIM281.93986842
21ACVR1B1.90817244
22SCYL21.83199251
23BMPR1B1.81195908
24MARK11.80920707
25PINK11.79173657
26NEK91.76627251
27GRK11.75537235
28TEC1.73145018
29PIK3CG1.71467960
30PTK21.69241814
31TNIK1.64802279
32EPHA41.52173929
33FGFR41.49866336
34DDR21.48241645
35BCKDK1.46963561
36TRIB31.45297585
37MAP2K71.43050234
38MAP2K61.42699702
39LIMK11.40959357
40BCR1.39744102
41MYLK1.36652564
42MAP2K11.34288736
43TAOK31.29012819
44FGFR21.28966098
45PRKCE1.28955308
46STK31.27232711
47PTK2B1.24201438
48EIF2AK31.23463159
49ERBB41.22660337
50MAPK131.20659666
51DYRK21.19407723
52NTRK31.16048193
53RPS6KB21.14444774
54SIK11.14180699
55ABL21.13313424
56OXSR11.09520980
57CSNK1A1L1.05307093
58NEK11.05258580
59DAPK21.04684868
60CDK81.03027655
61PDK20.97193064
62MAP2K20.93155273
63INSRR0.92215539
64TTK0.91532667
65SGK20.90680307
66CDK90.89762151
67ADRBK10.88959924
68PRKAA20.88448901
69MAP3K60.87978647
70GRK50.86614376
71TXK0.85318767
72PRKG20.82107598
73PAK30.81736648
74KSR20.80022566
75WNK40.79197989
76ROCK10.78362329
77STK100.77431848
78STK240.77294389
79PKN20.77189282
80LRRK20.77057231
81PRKD30.76097884
82MELK0.75989129
83PIK3CA0.71777763
84MST1R0.69757787
85PTK60.69214216
86TGFBR20.67475688
87MAPK110.66924562
88CDK60.64123211
89PRKCG0.64109887
90IRAK10.62274512
91MET0.61834597
92CSNK1G20.61364010
93MARK30.60093514
94MAP3K10.57825792
95NUAK10.57436232
96CAMK2B0.56267505
97PAK20.56142079
98EPHB10.55775512
99MAP3K30.54642640
100TLK10.54080284
101BLK0.51880684
102RIPK10.51463539
103TESK20.50109311
104STK390.48897710
105NLK0.47340178
106PHKG20.47072547
107PHKG10.47072547
108PDGFRA0.46816890
109CSNK1G10.46339277
110DYRK1B0.46052383
111ERBB20.45990515
112CHUK0.45949343
113LMTK20.44112668
114BUB10.43672648
115SIK30.43177911
116BRSK20.42948464
117PRKACA0.42809275
118CLK10.42755541
119PRKAA10.41458718
120TNK20.41413001
121TIE10.40688998
122CAMK2G0.40508691
123SGK4940.40431962
124SGK2230.40431962
125STK380.40116447
126FGFR10.39617564
127CASK0.39548106
128PRKCA0.39473845
129PRKCQ0.38869847
130RPS6KA40.38731892
131OBSCN0.38671468
132NME10.38601584
133SGK30.38294345
134CAMK2A0.38160831
135PBK0.37416255
136PLK30.37079100
137MAP3K80.36619384
138ABL10.36549832
139SRPK10.36316844
140PRKCH0.35773744
141CSNK1A10.35685773
142ITK0.34284631
143GSK3A0.33993233
144DYRK1A0.32708291
145RPS6KA50.32492152
146PRKD20.31546745
147IKBKB0.31357005
148PRKACB0.31069971
149MAPK100.30883116
150PLK20.30627974
151KDR0.28016606
152PRKG10.26929253
153PAK10.25487838
154AURKA0.25320484
155TGFBR10.25210732
156ERN10.25058322
157MTOR0.24812980
158AKT30.24466226
159PRKD10.24261838
160CSNK1G30.23543983
161AURKB0.22957551
162PKN10.22728223
163MAP3K70.21833771
164KSR10.21329744

Predicted pathways (KEGG)

RankGene SetZ-score
1Bladder cancer_Homo sapiens_hsa052193.10819329
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.02906056
3ECM-receptor interaction_Homo sapiens_hsa045123.01668582
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.99841573
5Caffeine metabolism_Homo sapiens_hsa002322.73079810
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.66576531
7Complement and coagulation cascades_Homo sapiens_hsa046102.54581385
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34066661
9Protein export_Homo sapiens_hsa030602.28917924
10Phototransduction_Homo sapiens_hsa047442.28593671
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24015592
12Linoleic acid metabolism_Homo sapiens_hsa005912.06794085
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02303455
14Nitrogen metabolism_Homo sapiens_hsa009101.99359574
15Tryptophan metabolism_Homo sapiens_hsa003801.97880060
16Arginine biosynthesis_Homo sapiens_hsa002201.95710409
17Basal transcription factors_Homo sapiens_hsa030221.94910555
18Circadian rhythm_Homo sapiens_hsa047101.91799922
19Fatty acid degradation_Homo sapiens_hsa000711.90145967
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.85587782
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.85207140
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80087934
23Fatty acid biosynthesis_Homo sapiens_hsa000611.79975616
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77717271
25Small cell lung cancer_Homo sapiens_hsa052221.74467274
26Regulation of autophagy_Homo sapiens_hsa041401.72628735
27Hippo signaling pathway_Homo sapiens_hsa043901.72034751
28TGF-beta signaling pathway_Homo sapiens_hsa043501.67304362
29RNA polymerase_Homo sapiens_hsa030201.63689966
30Olfactory transduction_Homo sapiens_hsa047401.61943795
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61567303
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61494302
33Tight junction_Homo sapiens_hsa045301.60037781
34Adherens junction_Homo sapiens_hsa045201.59230375
35Focal adhesion_Homo sapiens_hsa045101.59139825
36Ether lipid metabolism_Homo sapiens_hsa005651.57942377
37Axon guidance_Homo sapiens_hsa043601.56545390
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54770487
39Histidine metabolism_Homo sapiens_hsa003401.52879571
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51184315
41Protein digestion and absorption_Homo sapiens_hsa049741.43264219
42Taste transduction_Homo sapiens_hsa047421.41804499
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40800928
44ABC transporters_Homo sapiens_hsa020101.40476349
45Retinol metabolism_Homo sapiens_hsa008301.34388380
46Mineral absorption_Homo sapiens_hsa049781.32343180
47Pancreatic cancer_Homo sapiens_hsa052121.32102461
48Folate biosynthesis_Homo sapiens_hsa007901.31365600
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30846209
50Nicotine addiction_Homo sapiens_hsa050331.30500707
51Renin-angiotensin system_Homo sapiens_hsa046141.28987551
52Collecting duct acid secretion_Homo sapiens_hsa049661.27141008
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26661350
54Homologous recombination_Homo sapiens_hsa034401.25525971
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23127248
56Fanconi anemia pathway_Homo sapiens_hsa034601.21973669
57Chemical carcinogenesis_Homo sapiens_hsa052041.20194592
58Dorso-ventral axis formation_Homo sapiens_hsa043201.18398620
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17810034
60Thyroid cancer_Homo sapiens_hsa052161.17450792
61Peroxisome_Homo sapiens_hsa041461.17337241
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13261657
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12439124
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12355779
65Bile secretion_Homo sapiens_hsa049761.11982218
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10374841
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07707377
68Cell cycle_Homo sapiens_hsa041101.07538110
69beta-Alanine metabolism_Homo sapiens_hsa004101.06774538
70Amoebiasis_Homo sapiens_hsa051461.06604654
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04052129
72Asthma_Homo sapiens_hsa053101.03521499
73Proteoglycans in cancer_Homo sapiens_hsa052051.03494746
74Arachidonic acid metabolism_Homo sapiens_hsa005901.03360224
75Dilated cardiomyopathy_Homo sapiens_hsa054141.03336422
76MicroRNAs in cancer_Homo sapiens_hsa052061.02371824
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00055523
78PPAR signaling pathway_Homo sapiens_hsa033200.98819057
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91657788
80Ovarian steroidogenesis_Homo sapiens_hsa049130.90849713
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90337806
82Hedgehog signaling pathway_Homo sapiens_hsa043400.89601958
83Type I diabetes mellitus_Homo sapiens_hsa049400.89547559
84Oxidative phosphorylation_Homo sapiens_hsa001900.86757145
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85614065
86Primary immunodeficiency_Homo sapiens_hsa053400.85429560
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.84450647
88Glycerolipid metabolism_Homo sapiens_hsa005610.82996382
89RNA degradation_Homo sapiens_hsa030180.82736739
90Insulin secretion_Homo sapiens_hsa049110.81440086
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80915027
92Pyruvate metabolism_Homo sapiens_hsa006200.80340622
93Melanoma_Homo sapiens_hsa052180.79574608
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.79425133
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.77954902
96Phenylalanine metabolism_Homo sapiens_hsa003600.77584636
97Biosynthesis of amino acids_Homo sapiens_hsa012300.76837272
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75860035
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.75615057
100Selenocompound metabolism_Homo sapiens_hsa004500.75304993
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.74209490
102Tyrosine metabolism_Homo sapiens_hsa003500.74203512
103Glutathione metabolism_Homo sapiens_hsa004800.73447222
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.72310192
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70897456
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70800786
107Butanoate metabolism_Homo sapiens_hsa006500.69595247
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67197922
109Basal cell carcinoma_Homo sapiens_hsa052170.66708382
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65887035
111Sulfur metabolism_Homo sapiens_hsa009200.65746419
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65666965
113Prostate cancer_Homo sapiens_hsa052150.65488737
114Circadian entrainment_Homo sapiens_hsa047130.65466557
115Chronic myeloid leukemia_Homo sapiens_hsa052200.65141952
116Metabolic pathways_Homo sapiens_hsa011000.64893493
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63838319
118p53 signaling pathway_Homo sapiens_hsa041150.63750281
119Propanoate metabolism_Homo sapiens_hsa006400.63321241
120Salivary secretion_Homo sapiens_hsa049700.63104307
121Glioma_Homo sapiens_hsa052140.62729307
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61393132
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60867270
124Endometrial cancer_Homo sapiens_hsa052130.60245516
125One carbon pool by folate_Homo sapiens_hsa006700.59707718
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.59683623
127Arginine and proline metabolism_Homo sapiens_hsa003300.58838691
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58789518
129Pathways in cancer_Homo sapiens_hsa052000.56915800
130Allograft rejection_Homo sapiens_hsa053300.56548964
131Pyrimidine metabolism_Homo sapiens_hsa002400.56020368
132Notch signaling pathway_Homo sapiens_hsa043300.55562279
133Graft-versus-host disease_Homo sapiens_hsa053320.55184270
134Gap junction_Homo sapiens_hsa045400.54727905
135Rap1 signaling pathway_Homo sapiens_hsa040150.54457339
136GABAergic synapse_Homo sapiens_hsa047270.54034879
137Rheumatoid arthritis_Homo sapiens_hsa053230.53970675
138Serotonergic synapse_Homo sapiens_hsa047260.53586021
139Lysine degradation_Homo sapiens_hsa003100.53527066
140Fatty acid metabolism_Homo sapiens_hsa012120.53183685
141Autoimmune thyroid disease_Homo sapiens_hsa053200.52633768
142VEGF signaling pathway_Homo sapiens_hsa043700.51935267
143Calcium signaling pathway_Homo sapiens_hsa040200.51011321
144Fatty acid elongation_Homo sapiens_hsa000620.50751627
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50622317
146Non-small cell lung cancer_Homo sapiens_hsa052230.49975053
147Morphine addiction_Homo sapiens_hsa050320.48510795
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47695842
149Purine metabolism_Homo sapiens_hsa002300.47681110
150Non-homologous end-joining_Homo sapiens_hsa034500.45119500
151Starch and sucrose metabolism_Homo sapiens_hsa005000.44661457
152Glucagon signaling pathway_Homo sapiens_hsa049220.44111428
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.44027378
154Prion diseases_Homo sapiens_hsa050200.43685007
155Staphylococcus aureus infection_Homo sapiens_hsa051500.43447913
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43346212
157Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43268102
158Glutamatergic synapse_Homo sapiens_hsa047240.42681011
1592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39697743
160Leukocyte transendothelial migration_Homo sapiens_hsa046700.39361855
161Sphingolipid metabolism_Homo sapiens_hsa006000.39085997
162Cardiac muscle contraction_Homo sapiens_hsa042600.38275124
163Fat digestion and absorption_Homo sapiens_hsa049750.38187051
164Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38072656
165Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37208271
166Renin secretion_Homo sapiens_hsa049240.35447396

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