RAB11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)4.76735786
2membrane budding (GO:0006900)4.28522735
3negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.02237650
4positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.86254443
5water-soluble vitamin biosynthetic process (GO:0042364)3.75545232
6protein complex biogenesis (GO:0070271)3.61780771
7establishment of protein localization to mitochondrial membrane (GO:0090151)3.59506891
8electron transport chain (GO:0022900)3.47236444
9respiratory electron transport chain (GO:0022904)3.46615446
10endosome to pigment granule transport (GO:0043485)3.39858456
11endosome to melanosome transport (GO:0035646)3.39858456
12response to pheromone (GO:0019236)3.38752900
13mitochondrial respiratory chain complex assembly (GO:0033108)3.38069790
14protein maturation by protein folding (GO:0022417)3.35602301
15Golgi transport vesicle coating (GO:0048200)3.32544419
16COPI coating of Golgi vesicle (GO:0048205)3.32544419
17protein localization to cilium (GO:0061512)3.31135634
18sequestering of actin monomers (GO:0042989)3.16583582
19negative regulation of microtubule polymerization (GO:0031115)3.16408737
20regulation of neuron projection regeneration (GO:0070570)2.98093726
21regulation of axon regeneration (GO:0048679)2.98093726
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96971762
23mitochondrial respiratory chain complex I assembly (GO:0032981)2.96971762
24NADH dehydrogenase complex assembly (GO:0010257)2.96971762
25proteasome assembly (GO:0043248)2.95642477
26negative regulation of heart rate (GO:0010459)2.92999037
27protein deneddylation (GO:0000338)2.92299056
28aldehyde catabolic process (GO:0046185)2.89909852
29positive regulation of actin filament depolymerization (GO:0030836)2.88634761
30lactate metabolic process (GO:0006089)2.87582161
31dopamine transport (GO:0015872)2.87207647
32epithelial cilium movement (GO:0003351)2.81897578
33keratinocyte development (GO:0003334)2.81058206
34anterograde synaptic vesicle transport (GO:0048490)2.80404638
35magnesium ion transport (GO:0015693)2.79844613
36cullin deneddylation (GO:0010388)2.79497753
37protein K11-linked ubiquitination (GO:0070979)2.78219284
38pyrimidine nucleobase catabolic process (GO:0006208)2.75794485
39protein neddylation (GO:0045116)2.73518965
40histamine secretion (GO:0001821)2.73072187
41signal peptide processing (GO:0006465)2.72982073
42regulation of integrin-mediated signaling pathway (GO:2001044)2.72920006
43cytochrome complex assembly (GO:0017004)2.72536270
44peptidyl-cysteine modification (GO:0018198)2.71734990
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69760872
46regulation of cellular amino acid metabolic process (GO:0006521)2.69506543
47intestinal epithelial cell development (GO:0060576)2.69028183
48glycerol ether metabolic process (GO:0006662)2.67881794
49* melanosome transport (GO:0032402)2.66709039
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.66089533
51fatty acid elongation (GO:0030497)2.65995873
52negative regulation of cation channel activity (GO:2001258)2.65435961
53autophagic vacuole fusion (GO:0000046)2.64502912
54synaptic vesicle maturation (GO:0016188)2.64384942
55regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.63345352
56intraciliary transport (GO:0042073)2.61313950
57antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.60783267
58xenobiotic catabolic process (GO:0042178)2.60422242
59synaptic vesicle exocytosis (GO:0016079)2.58904063
60chaperone-mediated protein transport (GO:0072321)2.58527391
61positive regulation of vasculogenesis (GO:2001214)2.58288091
62regulation of synapse structural plasticity (GO:0051823)2.57856320
63ether metabolic process (GO:0018904)2.57381280
64regulation of synaptic vesicle exocytosis (GO:2000300)2.56845215
65regulation of autophagic vacuole assembly (GO:2000785)2.56543930
66regulation of cilium movement (GO:0003352)2.56515084
67neutrophil activation involved in immune response (GO:0002283)2.56055298
68mitochondrial calcium ion transport (GO:0006851)2.54431872
69positive regulation of vesicle fusion (GO:0031340)2.54228990
70inner mitochondrial membrane organization (GO:0007007)2.53837141
71negative regulation of homotypic cell-cell adhesion (GO:0034111)2.53730336
72Arp2/3 complex-mediated actin nucleation (GO:0034314)2.53657970
73cellular copper ion homeostasis (GO:0006878)2.53505958
74peroxisome fission (GO:0016559)2.53475321
75transferrin transport (GO:0033572)2.52937896
76ribonucleoprotein complex disassembly (GO:0032988)2.52709127
77hydrogen ion transmembrane transport (GO:1902600)2.52669981
78* establishment of melanosome localization (GO:0032401)2.51565292
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.51335977
80response to misfolded protein (GO:0051788)2.50812008
81* pigment granule transport (GO:0051904)2.49221458
82platelet dense granule organization (GO:0060155)2.48774410
83calcium-mediated signaling using intracellular calcium source (GO:0035584)2.48465486
84thrombin receptor signaling pathway (GO:0070493)2.46299393
85regulation of acyl-CoA biosynthetic process (GO:0050812)2.45728102
86positive regulation of protein autophosphorylation (GO:0031954)2.45693579
87organelle disassembly (GO:1903008)2.45453756
88protein retention in ER lumen (GO:0006621)2.44553698
89establishment of skin barrier (GO:0061436)2.44152988
90regulation of metalloenzyme activity (GO:0048552)2.44046761
91proton transport (GO:0015992)2.43752484
92maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43507179
93regulation of hexokinase activity (GO:1903299)2.43005367
94regulation of glucokinase activity (GO:0033131)2.43005367
95glutathione derivative metabolic process (GO:1901685)2.42704302
96glutathione derivative biosynthetic process (GO:1901687)2.42704302
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.41820825
98termination of RNA polymerase III transcription (GO:0006386)2.41820825
99axon cargo transport (GO:0008088)2.40758067
100fucosylation (GO:0036065)2.39814167
101desmosome organization (GO:0002934)2.39475407
102ether lipid metabolic process (GO:0046485)2.39324272
103hydrogen transport (GO:0006818)2.39159019
104negative regulation of dendrite morphogenesis (GO:0050774)2.38270473
105epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.37576918
106de novo protein folding (GO:0006458)2.36817460
107mitochondrial calcium ion homeostasis (GO:0051560)2.36729776
108* establishment of pigment granule localization (GO:0051905)2.35631584
109antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.35233240
110copper ion homeostasis (GO:0055070)2.35120041
111de novo posttranslational protein folding (GO:0051084)2.34881695
112L-phenylalanine catabolic process (GO:0006559)2.34310656
113erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.34310656
114cilium movement (GO:0003341)2.33575878
115negative regulation of response to food (GO:0032096)2.32484748
116negative regulation of appetite (GO:0032099)2.32484748
117regulation of synaptic vesicle transport (GO:1902803)2.32292218
118regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.32184018
119exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.31859005
120positive regulation of TOR signaling (GO:0032008)2.31281955
121regulation of cofactor metabolic process (GO:0051193)2.31107012
122regulation of coenzyme metabolic process (GO:0051196)2.31107012
123negative regulation of membrane potential (GO:0045837)2.30503276
124cilium organization (GO:0044782)2.30434643
125ferric iron transport (GO:0015682)2.30306115
126trivalent inorganic cation transport (GO:0072512)2.30306115
127ATP synthesis coupled proton transport (GO:0015986)2.30168714
128energy coupled proton transport, down electrochemical gradient (GO:0015985)2.30168714
129cilium assembly (GO:0042384)2.30163787
130protein targeting to plasma membrane (GO:0072661)2.30044446
131negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.29828293
132negative regulation of calcium ion transmembrane transport (GO:1903170)2.29828293
133mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.29491597
134respiratory chain complex IV assembly (GO:0008535)2.29380593
135nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.29204845
136polyol catabolic process (GO:0046174)2.29121206
137cellular response to glucagon stimulus (GO:0071377)2.28634837
138DNA double-strand break processing (GO:0000729)2.28420793
139positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.28268754
140positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.27345853
141regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.27341535
142anterograde axon cargo transport (GO:0008089)2.27092157
143negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.26717049
144negative regulation of ligase activity (GO:0051352)2.26717049
145regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.26445785
146deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.25540698
147intermediate filament organization (GO:0045109)2.24985903
148* melanosome localization (GO:0032400)2.24847197
149cilium morphogenesis (GO:0060271)2.24074165
150regulation of sulfur metabolic process (GO:0042762)2.23926943
151phagosome maturation (GO:0090382)2.23618212
152regulation of oxidative phosphorylation (GO:0002082)2.22705390
153heart contraction (GO:0060047)2.22617830
154heart process (GO:0003015)2.22617830
155regulation of cellular amine metabolic process (GO:0033238)2.22464814
156response to nitrosative stress (GO:0051409)2.20755984
157energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.20149581
158ATP hydrolysis coupled proton transport (GO:0015991)2.20149581
159vascular smooth muscle contraction (GO:0014829)2.19615592
160GDP-mannose metabolic process (GO:0019673)2.19413715
161positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.19388338
162positive regulation of mitochondrial fission (GO:0090141)2.19273418
163mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.19193380
164positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.19108099
165inositol phosphate catabolic process (GO:0071545)2.18063980
166regulation of type B pancreatic cell apoptotic process (GO:2000674)2.17514279
167organelle membrane fusion (GO:0090174)2.17091528
168establishment of synaptic vesicle localization (GO:0097480)2.17070140
169coenzyme A metabolic process (GO:0015936)2.16666109
170nonmotile primary cilium assembly (GO:0035058)2.16001156
171regulation of clathrin-mediated endocytosis (GO:2000369)2.15714091
172artery smooth muscle contraction (GO:0014824)2.13813676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.38537583
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.11010085
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.48485458
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83079113
5IGF1R_20145208_ChIP-Seq_DFB_Human2.79478343
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.72130449
7EWS_26573619_Chip-Seq_HEK293_Human2.51806459
8FUS_26573619_Chip-Seq_HEK293_Human2.40017812
9VDR_22108803_ChIP-Seq_LS180_Human2.23488695
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18753820
11* SOX2_20726797_ChIP-Seq_SW620_Human2.17713197
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16311505
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14990611
14TAF15_26573619_Chip-Seq_HEK293_Human2.12552454
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.11052094
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.09190111
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05903077
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02829106
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.98163158
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95173025
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93747571
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.93141887
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.92452472
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91830211
25HTT_18923047_ChIP-ChIP_STHdh_Human1.80443944
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76350135
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73507549
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72769263
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.66290545
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66222027
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.64217658
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61071443
33ZNF274_21170338_ChIP-Seq_K562_Hela1.58462419
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58319861
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57999712
36SMAD4_21799915_ChIP-Seq_A2780_Human1.56365878
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55688721
38RNF2_27304074_Chip-Seq_NSC_Mouse1.55337089
39* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54754090
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52745646
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51798932
42* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51211450
43FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51012405
44FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.50536846
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49934027
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47295605
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.46843934
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46395815
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45228331
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44631393
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44142620
52ZNF263_19887448_ChIP-Seq_K562_Human1.43443946
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42058428
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40718208
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40454093
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.40015521
57ER_23166858_ChIP-Seq_MCF-7_Human1.39203856
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.34279986
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33594736
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33533663
61P300_19829295_ChIP-Seq_ESCs_Human1.32370366
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32302884
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32302884
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30518801
65* GATA2_21666600_ChIP-Seq_HMVEC_Human1.29229078
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28458554
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.28144033
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26870354
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.26405835
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24077988
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23874302
72GBX2_23144817_ChIP-Seq_PC3_Human1.22752084
73P53_22387025_ChIP-Seq_ESCs_Mouse1.21441003
74VDR_23849224_ChIP-Seq_CD4+_Human1.20518307
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20319413
76* CJUN_26792858_Chip-Seq_BT549_Human1.19213171
77CDX2_22108803_ChIP-Seq_LS180_Human1.19026632
78* ELK1_22589737_ChIP-Seq_MCF10A_Human1.18818347
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18572067
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.18481976
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17632928
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17271004
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16519903
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15723955
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.15220130
86REST_19997604_ChIP-ChIP_NEURONS_Mouse1.15034064
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.15012987
88ESR1_21235772_ChIP-Seq_MCF-7_Human1.14654697
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.14373261
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.14173830
91* TCF4_22108803_ChIP-Seq_LS180_Human1.13852871
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13839831
93CBP_20019798_ChIP-Seq_JUKART_Human1.13839831
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.12092688
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12092688
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12082634
97SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11831011
98* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11260790
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10934728
100MYC_18940864_ChIP-ChIP_HL60_Human1.09751676
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08789769
102EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08789769
103TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.08598862
104* TAL1_26923725_Chip-Seq_HPCs_Mouse1.08416669
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05401847
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05287060
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05234132
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04947612
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.04830905
110STAT3_18555785_Chip-Seq_ESCs_Mouse1.04619458
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03641184
112SOX2_18555785_Chip-Seq_ESCs_Mouse1.03248505
113SALL4_22934838_ChIP-ChIP_CD34+_Human1.03158838
114AR_25329375_ChIP-Seq_VCAP_Human1.02599147
115* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02535837
116ELK1_19687146_ChIP-ChIP_HELA_Human1.01982319
117AR_21909140_ChIP-Seq_LNCAP_Human1.01969977
118NANOG_16153702_ChIP-ChIP_HESCs_Human1.01796482
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01630106
120JUN_21703547_ChIP-Seq_K562_Human1.00686259
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99443586
122CRX_20693478_ChIP-Seq_RETINA_Mouse0.99255397
123P300_18555785_Chip-Seq_ESCs_Mouse0.99131871
124NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98818075
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98273513
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98229108
127* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97450596
128NANOG_19829295_ChIP-Seq_ESCs_Human0.97430981
129SOX2_19829295_ChIP-Seq_ESCs_Human0.97430981
130EGR1_19032775_ChIP-ChIP_M12_Human0.96301983
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95712521
132TCF4_23295773_ChIP-Seq_U87_Human0.95275475
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94641230
134* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94278584
135P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91754519
136BCAT_22108803_ChIP-Seq_LS180_Human0.91741348
137JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91013815
138CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90914153
139HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89891117
140RNF2_27304074_Chip-Seq_ESCs_Mouse0.89818006
141* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88328185
142IRF8_22096565_ChIP-ChIP_GC-B_Human0.87697747
143FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86463092
144RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85558306
145RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85370677
146* REST_21632747_ChIP-Seq_MESCs_Mouse0.85011180
147CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83331139
148PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83128929
149SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82558208
150SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82558208
151TP63_23658742_ChIP-Seq_EP156T_Human0.81927509
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.81676457
153ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80204984
154PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79978558
155SRF_21415370_ChIP-Seq_HL-1_Mouse0.79555157
156Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79152109
157PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78953454
158* IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78128529
159NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76839347
160* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76662689
161ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76012165
162SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75971309
163E2F1_18555785_ChIP-Seq_MESCs_Mouse0.74647838
164EOMES_21245162_ChIP-Seq_HESCs_Human0.74388854
165JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73992629
166TP53_22573176_ChIP-Seq_HFKS_Human0.73075494
167PRDM14_20953172_ChIP-Seq_ESCs_Human0.72848499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006276_abnormal_autonomic_nervous4.21979842
2MP0010386_abnormal_urinary_bladder3.55879960
3MP0002735_abnormal_chemical_nociception3.20747172
4MP0001984_abnormal_olfaction2.68641496
5MP0002837_dystrophic_cardiac_calcinosis2.48633671
6MP0004270_analgesia2.44433196
7MP0002734_abnormal_mechanical_nocicepti2.43797459
8MP0002733_abnormal_thermal_nociception2.42182961
9MP0005084_abnormal_gallbladder_morpholo2.30039257
10MP0003880_abnormal_central_pattern2.27101939
11MP0005167_abnormal_blood-brain_barrier2.25897319
12MP0001968_abnormal_touch/_nociception2.24087200
13MP0004782_abnormal_surfactant_physiolog2.22111391
14MP0003724_increased_susceptibility_to2.19738787
15MP0009780_abnormal_chondrocyte_physiolo2.18063630
16MP0010234_abnormal_vibrissa_follicle2.14468370
17MP0006054_spinal_hemorrhage2.12994099
18MP0009379_abnormal_foot_pigmentation2.09984807
19MP0001348_abnormal_lacrimal_gland2.09838795
20MP0002796_impaired_skin_barrier2.07833157
21MP0010678_abnormal_skin_adnexa2.07434365
22MP0001970_abnormal_pain_threshold2.06445211
23MP0000013_abnormal_adipose_tissue2.06109881
24MP0004858_abnormal_nervous_system2.03937139
25MP0002736_abnormal_nociception_after1.98795628
26MP0002909_abnormal_adrenal_gland1.93374675
27MP0001879_abnormal_lymphatic_vessel1.90932215
28MP0006072_abnormal_retinal_apoptosis1.87153673
29MP0000372_irregular_coat_pigmentation1.84592376
30MP0002638_abnormal_pupillary_reflex1.82225081
31MP0004215_abnormal_myocardial_fiber1.80442481
32MP0004147_increased_porphyrin_level1.80262291
33MP0001905_abnormal_dopamine_level1.77666381
34MP0002163_abnormal_gland_morphology1.77231954
35MP0008877_abnormal_DNA_methylation1.75130658
36MP0001986_abnormal_taste_sensitivity1.73275751
37MP0005645_abnormal_hypothalamus_physiol1.63604647
38MP0002184_abnormal_innervation1.63426222
39MP0000681_abnormal_thyroid_gland1.63051060
40MP0003718_maternal_effect1.60753610
41MP0000538_abnormal_urinary_bladder1.59827762
42MP0002938_white_spotting1.59682428
43MP0003122_maternal_imprinting1.56978689
44MP0005248_abnormal_Harderian_gland1.56553435
45MP0003941_abnormal_skin_development1.54628190
46MP0003787_abnormal_imprinting1.52547035
47MP0000383_abnormal_hair_follicle1.52243900
48MP0010368_abnormal_lymphatic_system1.51601334
49MP0000647_abnormal_sebaceous_gland1.50353408
50MP0003879_abnormal_hair_cell1.50185361
51MP0005464_abnormal_platelet_physiology1.48688936
52MP0002148_abnormal_hypersensitivity_rea1.46049817
53MP0003011_delayed_dark_adaptation1.39364589
54MP0004859_abnormal_synaptic_plasticity1.37584281
55MP0001542_abnormal_bone_strength1.36403843
56MP0003183_abnormal_peptide_metabolism1.33192028
57MP0006036_abnormal_mitochondrial_physio1.31373259
58MP0003136_yellow_coat_color1.30285044
59MP0001188_hyperpigmentation1.28247347
60MP0008058_abnormal_DNA_repair1.27695190
61MP0004133_heterotaxia1.25742223
62MP0003121_genomic_imprinting1.24757665
63MP0003635_abnormal_synaptic_transmissio1.24615311
64MP0006035_abnormal_mitochondrial_morpho1.24294462
65MP0005379_endocrine/exocrine_gland_phen1.23220243
66MP0009697_abnormal_copulation1.22544664
67MP0002876_abnormal_thyroid_physiology1.22034191
68MP0002063_abnormal_learning/memory/cond1.20422163
69MP0000631_abnormal_neuroendocrine_gland1.19655659
70MP0008789_abnormal_olfactory_epithelium1.19148587
71MP0009785_altered_susceptibility_to1.19074953
72MP0001485_abnormal_pinna_reflex1.17139958
73MP0000427_abnormal_hair_cycle1.14747631
74MP0009046_muscle_twitch1.14240780
75MP0002102_abnormal_ear_morphology1.13921328
76MP0008872_abnormal_physiological_respon1.13008285
77MP0000778_abnormal_nervous_system1.11939881
78MP0004085_abnormal_heartbeat1.09871335
79MP0005253_abnormal_eye_physiology1.09529868
80MP0001529_abnormal_vocalization1.08078108
81MP0003329_amyloid_beta_deposits1.07858762
82MP0005275_abnormal_skin_tensile1.07831582
83MP0004811_abnormal_neuron_physiology1.06823540
84MP0003890_abnormal_embryonic-extraembry1.06650357
85MP0002295_abnormal_pulmonary_circulatio1.06306795
86MP0005646_abnormal_pituitary_gland1.04316189
87MP0005058_abnormal_lysosome_morphology1.04236417
88MP0005501_abnormal_skin_physiology1.03371821
89MP0002009_preneoplasia1.03351598
90MP0008057_abnormal_DNA_replication1.02821518
91MP0004142_abnormal_muscle_tone1.02623514
92MP0002693_abnormal_pancreas_physiology1.02468310
93MP0001664_abnormal_digestion1.01654369
94MP0004019_abnormal_vitamin_homeostasis1.01002144
95MP0002751_abnormal_autonomic_nervous1.00453446
96MP0003315_abnormal_perineum_morphology1.00336169
97MP0005367_renal/urinary_system_phenotyp0.99889856
98MP0000516_abnormal_urinary_system0.99889856
99MP0005174_abnormal_tail_pigmentation0.98707271
100MP0004885_abnormal_endolymph0.98382722
101MP0001756_abnormal_urination0.97368726
102MP0000343_altered_response_to0.97266242
103MP0004957_abnormal_blastocyst_morpholog0.96320037
104MP0000566_synostosis0.95888969
105MP0001440_abnormal_grooming_behavior0.95218888
106MP0002277_abnormal_respiratory_mucosa0.93346453
107MP0002233_abnormal_nose_morphology0.92743950
108MP0000230_abnormal_systemic_arterial0.92548790
109MP0008775_abnormal_heart_ventricle0.91963185
110MP0002557_abnormal_social/conspecific_i0.91457519
111MP0005551_abnormal_eye_electrophysiolog0.89721775
112MP0002234_abnormal_pharynx_morphology0.88475721
113MP0000358_abnormal_cell_content/0.87816535
114MP0005220_abnormal_exocrine_pancreas0.87670374
115MP0005408_hypopigmentation0.87636278
116MP0001299_abnormal_eye_distance/0.87608540
117MP0008260_abnormal_autophagy0.87325335
118MP0004883_abnormal_blood_vessel0.86910637
119MP0002067_abnormal_sensory_capabilities0.85508206
120MP0003567_abnormal_fetal_cardiomyocyte0.84987727
121MP0005394_taste/olfaction_phenotype0.82649099
122MP0005499_abnormal_olfactory_system0.82649099
123MP0003221_abnormal_cardiomyocyte_apopto0.82631825
124MP0009745_abnormal_behavioral_response0.81857919
125MP0002972_abnormal_cardiac_muscle0.81829887
126MP0003283_abnormal_digestive_organ0.80798096
127MP0003943_abnormal_hepatobiliary_system0.79519839
128MP0005332_abnormal_amino_acid0.79157360
129MP0002877_abnormal_melanocyte_morpholog0.78328618
130MP0005310_abnormal_salivary_gland0.78149896
131MP0003195_calcinosis0.77896096
132MP0000955_abnormal_spinal_cord0.77607161
133MP0002572_abnormal_emotion/affect_behav0.77363076
134MP0005164_abnormal_response_to0.77241642
135MP0002177_abnormal_outer_ear0.76640434
136MP0003937_abnormal_limbs/digits/tail_de0.76152836
137MP0009764_decreased_sensitivity_to0.75450865
138MP0002090_abnormal_vision0.75050870
139MP0003638_abnormal_response/metabolism_0.74801638
140MP0005636_abnormal_mineral_homeostasis0.74801229
141MP0000569_abnormal_digit_pigmentation0.74599888
142MP0002139_abnormal_hepatobiliary_system0.73883063
143MP0010771_integument_phenotype0.73638346
144MP0003186_abnormal_redox_activity0.73464559
145MP0005187_abnormal_penis_morphology0.73309008
146MP0000015_abnormal_ear_pigmentation0.73013684
147MP0002332_abnormal_exercise_endurance0.70260841
148MP0001944_abnormal_pancreas_morphology0.69616450
149MP0005166_decreased_susceptibility_to0.66253663
150MP0004084_abnormal_cardiac_muscle0.66125845
151MP0004510_myositis0.65813484
152MP0008004_abnormal_stomach_pH0.64603347
153MP0002272_abnormal_nervous_system0.63627978
154MP0004924_abnormal_behavior0.63429429
155MP0005386_behavior/neurological_phenoty0.63429429
156MP0001533_abnormal_skeleton_physiology0.62852572

Predicted human phenotypes

RankGene SetZ-score
1Mutism (HP:0002300)4.45596381
2Agitation (HP:0000713)4.12678154
3Hypothermia (HP:0002045)3.79057123
4Neuroendocrine neoplasm (HP:0100634)3.63605310
5Pheochromocytoma (HP:0002666)3.63590347
6Limb dystonia (HP:0002451)3.57987405
7Visual hallucinations (HP:0002367)3.52614697
8Acute encephalopathy (HP:0006846)3.38108054
9Hypoglycemic coma (HP:0001325)3.31753322
10Ankle clonus (HP:0011448)3.16589786
113-Methylglutaconic aciduria (HP:0003535)3.15475218
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.01628540
13Renal Fanconi syndrome (HP:0001994)2.95528260
14Ulnar claw (HP:0001178)2.91700192
15Increased CSF lactate (HP:0002490)2.91614793
16Dyschromatopsia (HP:0007641)2.85839685
17Methylmalonic acidemia (HP:0002912)2.84896451
18Hyperparathyroidism (HP:0000843)2.81593758
19Lipid accumulation in hepatocytes (HP:0006561)2.81220677
20Myokymia (HP:0002411)2.78660432
21Diminished motivation (HP:0000745)2.72431274
22Hyperinsulinemic hypoglycemia (HP:0000825)2.72097028
23Congenital, generalized hypertrichosis (HP:0004540)2.68630842
24Abnormality of the vocal cords (HP:0008777)2.66128673
25Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.64906754
26Papillary thyroid carcinoma (HP:0002895)2.60870723
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.60370247
28Disinhibition (HP:0000734)2.56413888
29Medial flaring of the eyebrow (HP:0010747)2.54955434
30Thyroid carcinoma (HP:0002890)2.53463116
31Apathy (HP:0000741)2.50438715
32Failure to thrive in infancy (HP:0001531)2.49922537
33Erythema (HP:0010783)2.47656559
34Glycosuria (HP:0003076)2.47472103
35Abnormality of urine glucose concentration (HP:0011016)2.47472103
36Congenital ichthyosiform erythroderma (HP:0007431)2.47221957
37Neoplasm of the adrenal gland (HP:0100631)2.46430108
38Retinal dysplasia (HP:0007973)2.43149929
39Pancreatic cysts (HP:0001737)2.42669310
40Lissencephaly (HP:0001339)2.42364168
41Abnormality of vitamin B metabolism (HP:0004340)2.42327776
42Abnormal ciliary motility (HP:0012262)2.41234827
43True hermaphroditism (HP:0010459)2.41195299
44Exertional dyspnea (HP:0002875)2.41132532
45Progressive neurologic deterioration (HP:0002344)2.40427059
46Menstrual irregularities (HP:0000858)2.39534400
47Cerebral edema (HP:0002181)2.38436535
48Hypoglycemic seizures (HP:0002173)2.36978631
49Hypercortisolism (HP:0001578)2.35507189
50Progressive inability to walk (HP:0002505)2.34836462
51Growth hormone excess (HP:0000845)2.32982702
52Aplasia/hypoplasia of the uterus (HP:0008684)2.32559827
53Polyphagia (HP:0002591)2.31248813
54Supranuclear gaze palsy (HP:0000605)2.29608466
55Menorrhagia (HP:0000132)2.29355509
56Acute necrotizing encephalopathy (HP:0006965)2.29238802
57Abnormal respiratory epithelium morphology (HP:0012253)2.29152840
58Abnormal respiratory motile cilium morphology (HP:0005938)2.29152840
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.28632878
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.27925761
61Nephronophthisis (HP:0000090)2.26761363
62Bradycardia (HP:0001662)2.26165465
63Abnormality of renal resorption (HP:0011038)2.25846306
64Mitochondrial inheritance (HP:0001427)2.25273809
65Petechiae (HP:0000967)2.25055901
66Abnormal mitochondria in muscle tissue (HP:0008316)2.24276544
67Increased mean platelet volume (HP:0011877)2.23837336
68Abnormal respiratory motile cilium physiology (HP:0012261)2.23450763
69Intestinal atresia (HP:0011100)2.23063429
70Rhinitis (HP:0012384)2.21751764
71Abnormality of calcium-phosphate metabolism (HP:0100530)2.21413379
72Abnormality of methionine metabolism (HP:0010901)2.21236423
73Segmental peripheral demyelination/remyelination (HP:0003481)2.20299616
74Pancreatic fibrosis (HP:0100732)2.19714462
75Renal cortical cysts (HP:0000803)2.18538385
76Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17612121
77Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17612121
78Vertebral compression fractures (HP:0002953)2.16413931
79Abnormality of midbrain morphology (HP:0002418)2.15035849
80Molar tooth sign on MRI (HP:0002419)2.15035849
81Cerebral hemorrhage (HP:0001342)2.14275244
82Congenital primary aphakia (HP:0007707)2.14247894
83Dysostosis multiplex (HP:0000943)2.13663710
84Hepatocellular necrosis (HP:0001404)2.13662440
85Poor head control (HP:0002421)2.12984636
86Generalized aminoaciduria (HP:0002909)2.10975566
87Restlessness (HP:0000711)2.10677620
88Proximal tubulopathy (HP:0000114)2.10132878
89Vacuolated lymphocytes (HP:0001922)2.08015902
90Biliary tract neoplasm (HP:0100574)2.06705594
91Prolonged bleeding time (HP:0003010)2.06129218
92Increased cerebral lipofuscin (HP:0011813)2.02955912
93Hepatic necrosis (HP:0002605)2.01200363
94Nephrogenic diabetes insipidus (HP:0009806)2.00939286
95Abnormality of the labia minora (HP:0012880)2.00309293
96Methylmalonic aciduria (HP:0012120)2.00111550
97Leukodystrophy (HP:0002415)1.99492061
98Tinnitus (HP:0000360)1.99467402
99Respiratory failure (HP:0002878)1.99291789
100Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99225034
101Degeneration of the lateral corticospinal tracts (HP:0002314)1.99225034
102Beaking of vertebral bodies (HP:0004568)1.97082463
103Inappropriate behavior (HP:0000719)1.96992712
104Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96648270
105Abnormality of alanine metabolism (HP:0010916)1.95781819
106Hyperalaninemia (HP:0003348)1.95781819
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95781819
108Akinesia (HP:0002304)1.94036159
109Anxiety (HP:0000739)1.93395944
110Genital tract atresia (HP:0001827)1.92870993
111Conjunctival hamartoma (HP:0100780)1.92693080
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92324512
113Inability to walk (HP:0002540)1.92324183
114Flared iliac wings (HP:0002869)1.92081811
115Papilledema (HP:0001085)1.91087851
116Postnatal microcephaly (HP:0005484)1.89385436
117Abnormality of magnesium homeostasis (HP:0004921)1.89118031
118Abnormal glycosylation (HP:0012345)1.88824313
119Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88824313
120Abnormal protein N-linked glycosylation (HP:0012347)1.88824313
121Abnormal protein glycosylation (HP:0012346)1.88824313
122Hypotrichosis (HP:0001006)1.88646398
123Tongue fasciculations (HP:0001308)1.88080999
124Increased serum pyruvate (HP:0003542)1.87769715
125Dysautonomia (HP:0002459)1.87625989
126Abnormality of the renal medulla (HP:0100957)1.87557732
127Abnormal biliary tract morphology (HP:0012440)1.87534711
128Progressive macrocephaly (HP:0004481)1.87181029
129Male pseudohermaphroditism (HP:0000037)1.86368867
130Distal arthrogryposis (HP:0005684)1.85984561
131Hypoplasia of the uterus (HP:0000013)1.85492546
132Delusions (HP:0000746)1.85488886
133Abnormality of liposaccharide metabolism (HP:0010968)1.85286432
134Abnormality of glycosphingolipid metabolism (HP:0004343)1.85286432
135Abnormality of glycolipid metabolism (HP:0010969)1.85286432
136Poor suck (HP:0002033)1.85229495
137Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83843952
138Vaginal atresia (HP:0000148)1.82911055
139Palpitations (HP:0001962)1.82743698
140Esotropia (HP:0000565)1.82251409
141Large for gestational age (HP:0001520)1.82056518
142Absent/shortened dynein arms (HP:0200106)1.81543270
143Dynein arm defect of respiratory motile cilia (HP:0012255)1.81543270
144Hyperphosphaturia (HP:0003109)1.81352462
145Increased hepatocellular lipid droplets (HP:0006565)1.80378883
146Palpebral edema (HP:0100540)1.80241305
147Abnormality of the vitamin B12 metabolism (HP:0004341)1.79802238
148Abnormal auditory evoked potentials (HP:0006958)1.79575806
149Parakeratosis (HP:0001036)1.79568417
150Abnormality of vitamin metabolism (HP:0100508)1.79011288
151Atrophy/Degeneration involving motor neurons (HP:0007373)1.78544648
152Abnormality of the renal cortex (HP:0011035)1.77464492
153Short nail (HP:0001799)1.75720127
154Torticollis (HP:0000473)1.75546082
155Increased serum lactate (HP:0002151)1.74731868
156Neurofibrillary tangles (HP:0002185)1.74268480
157Increased intramyocellular lipid droplets (HP:0012240)1.73979428
158Woolly hair (HP:0002224)1.73259225
159Lactic acidosis (HP:0003128)1.73219900
160Abnormal pupillary function (HP:0007686)1.73133275
161Type I transferrin isoform profile (HP:0003642)1.72734528
162Furrowed tongue (HP:0000221)1.72114182
163Shoulder girdle muscle weakness (HP:0003547)1.71842598
164Muscular hypotonia of the trunk (HP:0008936)1.71623866
165Pancreatic islet-cell hyperplasia (HP:0004510)1.71551728
166Abnormality of glycolysis (HP:0004366)1.71460062
167Gait imbalance (HP:0002141)1.71309834
168Delayed gross motor development (HP:0002194)1.71305597
169Abnormal platelet volume (HP:0011876)1.70676169
170Disproportionate short-trunk short stature (HP:0003521)1.70270524
171Testicular neoplasm (HP:0010788)1.69595141
172Median cleft lip (HP:0000161)1.69461266
173Hyperglycemia (HP:0003074)1.68760955
174Neoplasm of the peripheral nervous system (HP:0100007)1.68416020
175Craniofacial dystonia (HP:0012179)1.67428275
176Degeneration of anterior horn cells (HP:0002398)1.66434751
177Abnormality of the anterior horn cell (HP:0006802)1.66434751
178Symptomatic seizures (HP:0011145)1.66299191
179Absence seizures (HP:0002121)1.66187481
180Mucopolysacchariduria (HP:0008155)1.64620378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.10181282
2MARK13.32833351
3ARAF2.97035572
4LIMK12.95153348
5BCR2.89028604
6TRIM282.72187656
7MAPK152.53756926
8MAP4K22.46548835
9ACVR1B2.41815322
10SIK32.39896619
11MINK12.35715425
12TESK12.28520778
13DYRK22.23342052
14PIM22.23023772
15ERBB32.15199531
16MAP3K92.07950701
17TIE12.04985312
18MAPKAPK31.98228272
19BMPR1B1.93512675
20TNIK1.92607704
21BRSK21.74148024
22STK31.72418418
23PNCK1.57879403
24MAP3K111.57339713
25CDK81.50346757
26PLK31.49749494
27BRAF1.49712470
28MKNK21.47429452
29MAPK131.43084464
30STK38L1.42754120
31WNK31.41588947
32KDR1.41357116
33MAP3K31.40656889
34FER1.40194911
35MAP3K21.37059018
36MAP2K71.36836147
37KSR21.32122414
38NEK11.30458708
39KSR11.28183821
40MKNK11.27208897
41SRPK11.27042659
42BMPR21.26647187
43NTRK11.26468240
44ZAK1.25883217
45WEE11.21136955
46NUAK11.19305625
47STK241.17415092
48MAP3K41.16183181
49STK391.14145863
50SCYL21.14071150
51CSNK1G11.10686669
52TGFBR11.07939897
53MST41.07548323
54TSSK61.05944611
55MOS1.04963174
56CAMKK21.04298106
57BUB11.03418841
58INSRR1.02903048
59LATS21.02598797
60GRK51.01508909
61STK160.99587612
62MAPKAPK50.97908826
63EIF2AK10.95095515
64RIPK40.94682854
65GRK10.93319507
66OXSR10.92940627
67VRK10.92390515
68FGFR20.91755463
69ADRBK20.91253224
70PHKG10.89951198
71PHKG20.89951198
72MAP2K10.89874962
73YES10.86631529
74PBK0.85646044
75MAP3K10.85250516
76BLK0.82588663
77VRK20.78676884
78MATK0.78283712
79ABL20.77742146
80PLK40.75882252
81PRKG20.74177154
82PAK30.72606112
83TAF10.70236803
84MYLK0.68131510
85CDK140.66821673
86CSNK1G30.65627506
87MST1R0.65532769
88PTK2B0.64489662
89TGFBR20.64434643
90RAF10.64102572
91MAP2K20.62622858
92CSNK1G20.62578118
93EPHA30.62436569
94CSNK1A1L0.61766504
95MAP2K40.60361575
96PLK10.59712112
97PRKCG0.59531010
98TTK0.57989443
99GRK70.57927677
100TBK10.56176469
101NTRK20.56014930
102RPS6KA40.54328172
103CDK190.54318215
104TEC0.53858039
105FGFR10.53600345
106MAP2K60.53251026
107BMX0.52187473
108PLK20.51944502
109TAOK10.51932501
110AURKA0.51305053
111CASK0.50901649
112CDK50.50866736
113NME10.50673731
114PIK3CA0.50663949
115EPHB20.50341452
116STK40.49428696
117PINK10.46961661
118PIK3CG0.46706017
119PASK0.46135256
120PAK40.45772293
121DAPK30.44099968
122EIF2AK30.44028813
123NEK90.44009628
124NTRK30.43815214
125DYRK1A0.43419781
126AKT30.43183467
127MAP3K50.42984867
128ILK0.42926645
129DAPK20.42573601
130NLK0.42438567
131RET0.41674123
132* PRKCE0.40712898
133LMTK20.40293083
134BRSK10.39527611
135CSNK1E0.39338558
136PRKCZ0.38898466
137DYRK1B0.38566645
138ADRBK10.38272363
139CAMK2A0.38054623
140MUSK0.37898357
141NME20.37791226
142DYRK30.37117612
143ROCK20.37078153
144EIF2AK20.35977292
145IRAK10.35226636
146PDK20.34994331
147CDK180.34776098
148DAPK10.34037055
149UHMK10.33870560
150PRKG10.33738665
151CAMK2D0.33103958
152FRK0.32788390
153PRKCI0.31813989

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.91104443
2Protein export_Homo sapiens_hsa030602.82262722
3Synaptic vesicle cycle_Homo sapiens_hsa047212.47248799
4Vibrio cholerae infection_Homo sapiens_hsa051102.46016419
5Oxidative phosphorylation_Homo sapiens_hsa001902.36953286
6Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.36183609
7Parkinsons disease_Homo sapiens_hsa050122.23715964
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.22921049
9Fatty acid elongation_Homo sapiens_hsa000622.07855659
10Collecting duct acid secretion_Homo sapiens_hsa049661.97958214
11Propanoate metabolism_Homo sapiens_hsa006401.89908366
12Steroid biosynthesis_Homo sapiens_hsa001001.85927989
13Alzheimers disease_Homo sapiens_hsa050101.68942651
14Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.66977406
15Butanoate metabolism_Homo sapiens_hsa006501.59003995
16Serotonergic synapse_Homo sapiens_hsa047261.51194602
17Shigellosis_Homo sapiens_hsa051311.51099382
18Phagosome_Homo sapiens_hsa041451.50985890
19Glutathione metabolism_Homo sapiens_hsa004801.50127789
20Rheumatoid arthritis_Homo sapiens_hsa053231.47327774
21* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46817435
22Folate biosynthesis_Homo sapiens_hsa007901.46358571
23Huntingtons disease_Homo sapiens_hsa050161.46350733
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44820408
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38754513
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.38635260
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37202654
28Basal transcription factors_Homo sapiens_hsa030221.35594319
29Lysosome_Homo sapiens_hsa041421.34459943
30Sphingolipid metabolism_Homo sapiens_hsa006001.32033770
31Salmonella infection_Homo sapiens_hsa051321.31412762
32Dopaminergic synapse_Homo sapiens_hsa047281.30159042
33Mismatch repair_Homo sapiens_hsa034301.28224864
34Olfactory transduction_Homo sapiens_hsa047401.26513956
35Nitrogen metabolism_Homo sapiens_hsa009101.21677641
36Regulation of autophagy_Homo sapiens_hsa041401.17388882
37Phototransduction_Homo sapiens_hsa047441.15686887
38* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14881844
39Pertussis_Homo sapiens_hsa051331.14087078
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12665368
41Sulfur metabolism_Homo sapiens_hsa009201.10988355
42beta-Alanine metabolism_Homo sapiens_hsa004101.10965199
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10467973
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10071836
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08740333
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08535277
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08452164
48Legionellosis_Homo sapiens_hsa051341.08300155
49Vitamin B6 metabolism_Homo sapiens_hsa007501.02108763
50Cholinergic synapse_Homo sapiens_hsa047251.02075293
51Non-homologous end-joining_Homo sapiens_hsa034501.00670757
52Taste transduction_Homo sapiens_hsa047421.00634203
53N-Glycan biosynthesis_Homo sapiens_hsa005100.99935418
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99642712
55Circadian entrainment_Homo sapiens_hsa047130.99533490
56RNA degradation_Homo sapiens_hsa030180.98907930
57Peroxisome_Homo sapiens_hsa041460.98239518
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94842534
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94469711
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.93467581
61Oocyte meiosis_Homo sapiens_hsa041140.92253319
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91618943
63Pyruvate metabolism_Homo sapiens_hsa006200.91520916
64Insulin secretion_Homo sapiens_hsa049110.90425400
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87743613
66Cocaine addiction_Homo sapiens_hsa050300.86485472
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86171236
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85798705
69Cardiac muscle contraction_Homo sapiens_hsa042600.84521747
70Circadian rhythm_Homo sapiens_hsa047100.84115483
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83424227
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82727312
73* Endocytosis_Homo sapiens_hsa041440.82659072
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81939169
75Homologous recombination_Homo sapiens_hsa034400.81409169
76Purine metabolism_Homo sapiens_hsa002300.80327154
77GABAergic synapse_Homo sapiens_hsa047270.78923547
78GnRH signaling pathway_Homo sapiens_hsa049120.78171740
79RNA transport_Homo sapiens_hsa030130.78153672
80Metabolic pathways_Homo sapiens_hsa011000.77144933
81Arachidonic acid metabolism_Homo sapiens_hsa005900.76528514
82Chemical carcinogenesis_Homo sapiens_hsa052040.75707497
83VEGF signaling pathway_Homo sapiens_hsa043700.75148537
84Ether lipid metabolism_Homo sapiens_hsa005650.74972056
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73201075
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72261281
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70930849
88Long-term potentiation_Homo sapiens_hsa047200.69963135
89Tryptophan metabolism_Homo sapiens_hsa003800.69683128
90Mineral absorption_Homo sapiens_hsa049780.69613644
91Thyroid cancer_Homo sapiens_hsa052160.69325146
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69283819
93Long-term depression_Homo sapiens_hsa047300.68589037
94Leishmaniasis_Homo sapiens_hsa051400.68197193
95Nucleotide excision repair_Homo sapiens_hsa034200.66171006
96Type I diabetes mellitus_Homo sapiens_hsa049400.65996984
97Retinol metabolism_Homo sapiens_hsa008300.65953568
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.65918852
99Amphetamine addiction_Homo sapiens_hsa050310.65649729
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.65529661
101Gap junction_Homo sapiens_hsa045400.65346539
102Ras signaling pathway_Homo sapiens_hsa040140.64898554
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63264995
104Glutamatergic synapse_Homo sapiens_hsa047240.61881300
105TNF signaling pathway_Homo sapiens_hsa046680.61643249
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61286062
107Axon guidance_Homo sapiens_hsa043600.60934092
108RNA polymerase_Homo sapiens_hsa030200.59934344
109Other glycan degradation_Homo sapiens_hsa005110.59505426
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59193145
111Tuberculosis_Homo sapiens_hsa051520.58705730
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56109253
113Prion diseases_Homo sapiens_hsa050200.55048545
114Platelet activation_Homo sapiens_hsa046110.54943878
115Pyrimidine metabolism_Homo sapiens_hsa002400.54905316
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.52900753
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52815430
118Fanconi anemia pathway_Homo sapiens_hsa034600.51995146
119Tyrosine metabolism_Homo sapiens_hsa003500.51514352
120Arginine and proline metabolism_Homo sapiens_hsa003300.51404566
121Fatty acid metabolism_Homo sapiens_hsa012120.51387117
122Alcoholism_Homo sapiens_hsa050340.51314374
123Tight junction_Homo sapiens_hsa045300.51110051
124Renin secretion_Homo sapiens_hsa049240.51107795
125Prolactin signaling pathway_Homo sapiens_hsa049170.50588980
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50412629
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49732959
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.49207684
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49104699
130Oxytocin signaling pathway_Homo sapiens_hsa049210.48115104
131Nicotine addiction_Homo sapiens_hsa050330.47710835
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.47361861
133Epstein-Barr virus infection_Homo sapiens_hsa051690.46754384
134ErbB signaling pathway_Homo sapiens_hsa040120.46751076
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46025044
136Linoleic acid metabolism_Homo sapiens_hsa005910.46019442
137Renal cell carcinoma_Homo sapiens_hsa052110.44690088
138Morphine addiction_Homo sapiens_hsa050320.44460310
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44143729
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43306112
141Fatty acid degradation_Homo sapiens_hsa000710.43098368
142Ribosome_Homo sapiens_hsa030100.43044411
143Ovarian steroidogenesis_Homo sapiens_hsa049130.42526873
144Spliceosome_Homo sapiens_hsa030400.42454912
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42170655
146Chemokine signaling pathway_Homo sapiens_hsa040620.41896169
147Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41876097
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40377269
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40163152
150Glycosaminoglycan degradation_Homo sapiens_hsa005310.40085505
151Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39432966
152AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39108273
153Selenocompound metabolism_Homo sapiens_hsa004500.37052939
154Histidine metabolism_Homo sapiens_hsa003400.35636132
155Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35552875

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